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Markella V. Zanni, M.D.

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Research
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  1. R01HL137562 (ZANNI, MARKELLA V.) Jul 1, 2017 - Mar 31, 2021
    NIH/NHLBI
    Mechanisms of Cardiac Dysfunction in HIV and the Effect of Statins
    Role: Principal Investigator (MPI)
  2. R01AI123001 (ZANNI, MARKELLA V.) Sep 25, 2015 - Feb 29, 2020
    NIH/NIAD
    Cardiovascular Disease Risk in HIV-infected Women: Sex-Specific Mechanisms of Risk and Risk Reduction among REPRIEVE Trial Participants
    Role: Principal Investigator (MPI)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zanni MV, Awadalla M, Toribio M, Robinson J, Stone LA, Cagliero D, Rokicki A, Mulligan CP, Ho JE, Neilan AM, Siedner MJ, Triant VA, Stanley TL, Szczepaniak LS, Jerosch-Herold M, Nelson MD, Burdo TH, Neilan TG. Immune Correlates of Diffuse Myocardial Fibrosis and Diastolic Dysfunction Among Aging Women With Human Immunodeficiency Virus. J Infect Dis. 2019 May 17. PMID: 31100122.
    Citations:    
  2. Zanni MV, Grinspoon SK. Striving to characterize endocrine-metabolic and immune health risks among transgender women with HIV. AIDS. 2019 Apr 01; 33(5):919-922. PMID: 30882492.
    Citations:    
  3. Hoffmann U, Lu MT, Olalere D, Adami EC, Osborne MT, Ivanov A, Aluru JS, Lee S, Arifovic N, Overton ET, Fichtenbaum CJ, Aberg JA, Alston-Smith B, Klingman KL, Waclawiw M, Burdo TH, Williams KC, Zanni MV, Desvigne-Nickens P, Cooper-Arnold K, Fitch KV, Ribaudo H, Douglas PS, Grinspoon SK. Rationale and design of the Mechanistic Substudy of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE): Effects of pitavastatin on coronary artery disease and inflammatory biomarkers. Am Heart J. 2019 Mar 04; 212:1-12. PMID: 30928823.
    Citations:    
  4. Grinspoon SK, Fitch KV, Overton ET, Fichtenbaum CJ, Zanni MV, Aberg JA, Malvestutto C, Lu MT, Currier JS, Sponseller CA, Waclawiw M, Alston-Smith B, Cooper-Arnold K, Klingman KL, Desvigne-Nickens P, Hoffmann U, Ribaudo HJ, Douglas PS. Rationale and design of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE). Am Heart J. 2019 Mar 04; 212:23-35. PMID: 30928825.
    Citations:    
  5. Gogia S, Zanni MV. Reply. J Acquir Immune Defic Syndr. 2019 Mar 01; 80(3):e84-e85. PMID: 30762676.
    Citations:    
  6. Srinivasa S, Fitch KV, Torriani M, Zanni MV, Defilippi C, Christenson R, Maehler P, Looby SE, Lo J, Grinspoon SK. Relationship of visceral and subcutaneous adipose depots to markers of arterial injury and inflammation among individuals with HIV. AIDS. 2019 Feb 01; 33(2):229-236. PMID: 30325779.
    Citations:    Fields:    
  7. Alvi RM, Afshar M, Neilan AM, Tariq N, Hassan M, Gerber J, Awadalla M, Mulligan CP, Rokicki A, Triant VA, Zanni MV, Neilan TG. Heart failure and adverse heart failure outcomes among persons living with HIV in a US tertiary medical center. Am Heart J. 2019 Apr; 210:39-48. PMID: 30731372.
    Citations:    
  8. Gogia S, Zanni MV. Authors' Reply to Comments on "Cardiovascular Risk Profile of Transgender Women with HIV: A U.S. Healthcare Database Study". J Acquir Immune Defic Syndr. 2019 Jan 09. PMID: 30633042.
    Citations:    Fields:    
  9. Mosepele M, Regan S, Massaro J, Meigs JB, Zanni MV, D'Agostino RB, Grinspoon SK, Triant VA. Impact of the American College of Cardiology/American Heart Association Cholesterol Guidelines on Statin Eligibility Among Human Immunodeficiency Virus-Infected Individuals. Open Forum Infect Dis. 2018 Dec; 5(12):ofy326. PMID: 30619912.
    Citations:    
  10. Alvi RM, Neilan AM, Tariq N, Awadalla M, Rokicki A, Hassan M, Afshar M, Mulligan CP, Triant VA, Zanni MV, Neilan TG. Incidence, Predictors, and Outcomes of Implantable Cardioverter-Defibrillator Discharge Among People Living With HIV. J Am Heart Assoc. 2018 Sep 18; 7(18):e009857. PMID: 30371221.
    Citations: 1     Fields:    
  11. Gogia S, Coromilas A, Regan S, Stone L, Fourman LT, Triant VA, Neilan TG, Zanni MV. Cardiovascular Risk Profile of Transgender Women With HIV: A US Health Care Database Study. J Acquir Immune Defic Syndr. 2018 Sep 01; 79(1):e39-e41. PMID: 29847481.
    Citations:    Fields:    
  12. Toribio M, Fitch KV, Stone L, Zanni MV, Lo J, de Filippi C, Sponseller CA, Lee H, Grundberg I, Thompson MA, Aberg JA, Grinspoon SK. Assessing statin effects on cardiovascular pathways in HIV using a novel proteomics approach: Analysis of data from INTREPID, a randomized controlled trial. EBioMedicine. 2018 Sep; 35:58-66. PMID: 30174281.
    Citations:    Fields:    Translation:Humans
  13. Siedner MJ, Zanni M, Tracy RP, Kwon DS, Tsai AC, Kakuhire B, Hunt PW, Okello S. Increased Systemic Inflammation and Gut Permeability Among Women With Treated HIV Infection in Rural Uganda. J Infect Dis. 2018 Aug 14; 218(6):922-926. PMID: 29718342.
    Citations:    Fields:    
  14. Foldyna B, Fourman LT, Lu MT, Mueller ME, Szilveszter B, Neilan TG, Ho JE, Burdo TH, Lau ES, Stone LA, Toribio M, Srinivasa S, Looby SE, Lo J, Fitch KV, Zanni MV. Sex Differences in Subclinical Coronary Atherosclerotic Plaque Among Individuals With HIV on Antiretroviral Therapy. J Acquir Immune Defic Syndr. 2018 Aug 01; 78(4):421-428. PMID: 29601406.
    Citations: 1     Fields:    
  15. Alvi RM, Neilan AM, Tariq N, Awadalla M, Afshar M, Banerji D, Rokicki A, Mulligan C, Triant VA, Zanni MV, Neilan TG. Protease Inhibitors and Cardiovascular Outcomes in Patients With HIV and Heart Failure. J Am Coll Cardiol. 2018 Jul 31; 72(5):518-530. PMID: 30049313.
    Citations:    Fields:    
  16. Alvi RM, Tariq N, Malhotra A, Awadalla M, Triant VA, Zanni MV, Neilan TG. Sleep Apnea and Heart Failure With a Reduced Ejection Fraction Among Persons Living With Human Immunodeficiency Virus. Clin Infect Dis. 2018 Jul 18; 67(3):447-455. PMID: 29534158.
    Citations:    Fields:    
  17. Savji N, Meijers WC, Bartz TM, Bhambhani V, Cushman M, Nayor M, Kizer JR, Sarma A, Blaha MJ, Gansevoort RT, Gardin JM, Hillege HL, Ji F, Kop WJ, Lau ES, Lee DS, Sadreyev R, van Gilst WH, Wang TJ, Zanni MV, Vasan RS, Allen NB, Psaty BM, van der Harst P, Levy D, Larson M, Shah SJ, de Boer RA, Gottdiener JS, Ho JE. The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF. JACC Heart Fail. 2018 Aug; 6(8):701-709. PMID: 30007554.
    Citations:    Fields:    
  18. deFilippi C, Lo J, Christenson R, Grundberg I, Stone L, Zanni MV, Lee H, Grinspoon SK. Novel mediators of statin effects on plaque in HIV: a proteomics approach. AIDS. 2018 Apr 24; 32(7):867-876. PMID: 29369166.
    Citations:    Fields:    
  19. Chow FC, Regan S, Zanni MV, Looby SE, Bushnell CD, Meigs JB, Grinspoon SK, Feske SK, Triant VA. Elevated ischemic stroke risk among women living with HIV infection. AIDS. 2018 Jan 02; 32(1):59-67. PMID: 28926405.
    Citations:    Fields:    Translation:Humans
  20. Srinivasa S, Lu MT, Fitch KV, Hallett TR, O'Malley TK, Stone LA, Martin A, Coromilas AJ, Burdo TH, Triant VA, Lo J, Looby SE, Neilan TG, Zanni MV. Epicardial adipose tissue volume and cardiovascular risk indices among asymptomatic women with and without HIV. Antivir Ther. 2018; 23(1):1-9. PMID: 28930079.
    Citations:    Fields:    
  21. Raghavan A, Rimmelin DE, Fitch KV, Zanni MV. Sex Differences in Select Non-communicable HIV-Associated Comorbidities: Exploring the Role of Systemic Immune Activation/Inflammation. Curr HIV/AIDS Rep. 2017 12; 14(6):220-228. PMID: 29080122.
    Citations: 4     Fields:    Translation:Humans
  22. Toribio M, Park MH, Zanni MV, Robbins GK, Burdo TH, Williams KC, Feldpausch MN, Stone L, Melbourne K, Grinspoon SK, Fitzgerald ML. HDL Cholesterol Efflux Capacity in Newly Diagnosed HIV and Effects of Antiretroviral Therapy. J Clin Endocrinol Metab. 2017 11 01; 102(11):4250-4259. PMID: 28945911.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  23. Stone L, Looby SE, Zanni MV. Cardiovascular disease risk among women living with HIV in North America and Europe. Curr Opin HIV AIDS. 2017 Nov; 12(6):585-593. PMID: 28832367.
    Citations: 2     Fields:    Translation:Humans
  24. Zanni MV, Stone LA, Toribio M, Rimmelin DE, Robinson J, Burdo TH, Williams K, Fitch KV, Lo J, Grinspoon SK. Proprotein Convertase Subtilisin/Kexin 9 Levels in Relation to Systemic Immune Activation and Subclinical Coronary Plaque in HIV. Open Forum Infect Dis. 2017; 4(4):ofx227. PMID: 29226174.
    Citations:    
  25. Janjua SA, Staziaki PV, Szilveszter B, Takx RAP, Mayrhofer T, Hennessy O, Emami HA, Park J, Ivanov A, Hallett TR, Lu MT, Romero JM, Grinspoon SK, Hoffmann U, Zanni MV, Neilan TG. Presence, Characteristics, and Prognostic Associations of Carotid Plaque Among People Living With HIV. Circ Cardiovasc Imaging. 2017 10; 10(10). PMID: 29021257.
    Citations: 3     Fields:    Translation:Humans
  26. Hall LN, Sanchez LR, Hubbard J, Lee H, Looby SE, Srinivasa S, Zanni MV, Stanley TL, Lo J, Grinspoon SK, Fitch KV. Aspartame Intake Relates to Coronary Plaque Burden and Inflammatory Indices in Human Immunodeficiency Virus. Open Forum Infect Dis. 2017; 4(2):ofx083. PMID: 28695142.
    Citations:    
  27. Zanni MV, Toribio M, Wilks MQ, Lu MT, Burdo TH, Walker J, Autissier P, Foldyna B, Stone L, Martin A, Cope F, Abbruzzese B, Brady T, Hoffmann U, Williams KC, El-Fakhri G, Grinspoon SK. Application of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals. J Infect Dis. 2017 04 15; 215(8):1264-1269. PMID: 28204544.
    Citations: 5     Fields:    Translation:HumansCells
  28. Toribio M, Fitch KV, Sanchez L, Burdo TH, Williams KC, Sponseller CA, McCurdy Pate M, Aberg JA, Zanni MV, Grinspoon SK. Effects of pitavastatin and pravastatin on markers of immune activation and arterial inflammation in HIV. AIDS. 2017 03 27; 31(6):797-806. PMID: 28252528.
    Citations: 6     Fields:    Translation:Humans
  29. Zanni MV, Fitch K, Rivard C, Sanchez L, Douglas PS, Grinspoon S, Smeaton L, Currier JS, Looby SE. Follow YOUR Heart: development of an evidence-based campaign empowering older women with HIV to participate in a large-scale cardiovascular disease prevention trial. HIV Clin Trials. 2017 03; 18(2):83-91. PMID: 28277924.
    Citations: 1     Fields:    Translation:Humans
  30. Janjua SA, Triant VA, Addison D, Szilveszter B, Regan S, Staziaki PV, Grinspoon SA, Hoffmann U, Zanni MV, Neilan TG. HIV Infection and Heart Failure Outcomes in Women. J Am Coll Cardiol. 2017 01 03; 69(1):107-108. PMID: 28057235.
    Citations: 5     Fields:    Translation:HumansCells
  31. Fitch KV, DeFilippi C, Christenson R, Srinivasa S, Lee H, Lo J, Lu MT, Wong K, Petrow E, Sanchez L, Looby SE, Hoffmann U, Zanni M, Grinspoon SK. Subclinical myocyte injury, fibrosis and strain in relationship to coronary plaque in asymptomatic HIV-infected individuals. AIDS. 2016 09 10; 30(14):2205-14. PMID: 27314177.
    Citations: 6     Fields:    Translation:HumansCells
  32. Zanni MV, Toribio M, Robbins GK, Burdo TH, Lu MT, Ishai AE, Feldpausch MN, Martin A, Melbourne K, Triant VA, Suchindran S, Lee H, Hoffmann U, Williams KC, Tawakol A, Grinspoon SK. Effects of Antiretroviral Therapy on Immune Function and Arterial Inflammation in Treatment-Naive Patients With Human Immunodeficiency Virus Infection. JAMA Cardiol. 2016 07 01; 1(4):474-80. PMID: 27438325.
    Citations: 14     Fields:    Translation:Humans
  33. Looby SE, Fitch KV, Srinivasa S, Lo J, Rafferty D, Martin A, Currier JC, Grinspoon S, Zanni MV. Reduced ovarian reserve relates to monocyte activation and subclinical coronary atherosclerotic plaque in women with HIV. AIDS. 2016 Jan 28; 30(3):383-93. PMID: 26696388.
    Citations: 6     Fields:    Translation:HumansCells
  34. Zanni MV, Schouten J, Grinspoon SK, Reiss P. Risk of coronary heart disease in patients with HIV infection. Nat Rev Cardiol. 2014 Dec; 11(12):728-41. PMID: 25331088.
    Citations: 28     Fields:    Translation:Humans
  35. Zanni MV, Fitch KV, Feldpausch M, Han A, Lee H, Lu MT, Abbara S, Ribaudo H, Douglas PS, Hoffmann U, Lo J, Grinspoon SK. 2013 American College of Cardiology/American Heart Association and 2004 Adult Treatment Panel III cholesterol guidelines applied to HIV-infected patients with/without subclinical high-risk coronary plaque. AIDS. 2014 Sep 10; 28(14):2061-70. PMID: 25265074.
    Citations: 27     Fields:    Translation:Humans
  36. Tawakol A, Lo J, Zanni MV, Marmarelis E, Ihenachor EJ, MacNabb M, Wai B, Hoffmann U, Abbara S, Grinspoon S. Increased arterial inflammation relates to high-risk coronary plaque morphology in HIV-infected patients. J Acquir Immune Defic Syndr. 2014 Jun 01; 66(2):164-71. PMID: 24828267.
    Citations: 20     Fields:    Translation:Humans
  37. Zanni MV, Kelesidis T, Fitzgerald ML, Lo J, Abbara S, Wai B, Marmarelis E, Hernandez NJ, Yang OO, Currier JS, Grinspoon SK. HDL redox activity is increased in HIV-infected men in association with macrophage activation and non-calcified coronary atherosclerotic plaque. Antivir Ther. 2014; 19(8):805-811. PMID: 24535655.
    Citations: 11     Fields:    Translation:HumansCells
  38. Zanni MV, Abbara S, Lo J, Wai B, Hark D, Marmarelis E, Grinspoon SK. Increased coronary atherosclerotic plaque vulnerability by coronary computed tomography angiography in HIV-infected men. AIDS. 2013 May 15; 27(8):1263-72. PMID: 23324657.
    Citations: 42     Fields:    Translation:Humans
  39. Torriani M, Zanni MV, Fitch K, Stavrou E, Bredella MA, Lim R, Cypess AM, Grinspoon S. Increased FDG uptake in association with reduced extremity fat in HIV patients. Antivir Ther. 2013; 18(2):243-8. PMID: 23041595.
    Citations: 5     Fields:    Translation:Humans
  40. Zanni MV, Burdo TH, Makimura H, Williams KC, Grinspoon SK. Relationship between monocyte/macrophage activation marker soluble CD163 and insulin resistance in obese and normal-weight subjects. Clin Endocrinol (Oxf). 2012 Sep; 77(3):385-90. PMID: 22098563.
    Citations: 24     Fields:    Translation:Humans
  41. Zanni MV, Grinspoon SK. HIV-specific immune dysregulation and atherosclerosis. Curr HIV/AIDS Rep. 2012 Sep; 9(3):200-5. PMID: 22638983.
    Citations: 9     Fields:    Translation:Humans
  42. Subramanian S, Tawakol A, Burdo TH, Abbara S, Wei J, Vijayakumar J, Corsini E, Abdelbaky A, Zanni MV, Hoffmann U, Williams KC, Lo J, Grinspoon SK. Arterial inflammation in patients with HIV. JAMA. 2012 Jul 25; 308(4):379-86. PMID: 22820791.
    Citations: 157     Fields:    Translation:HumansCells
  43. Zanni MV. Dyslipidemia in Cushing’s Disease. Massachusetts General Hospital Neuroendocrine and Pituitary Tumor Center. Volume 19, Issue 1. 2012.
  44. Ahima RS, Stanley TL, Khor VK, Zanni MV, Grinspoon SK. Estrogen sulfotransferase is expressed in subcutaneous adipose tissue of obese humans in association with TNF-alpha and SOCS3. J Clin Endocrinol Metab. 2011 Jul; 96(7):E1153-8. PMID: 21543429.
    Citations: 8     Fields:    Translation:Humans
  45. Stanley TL, Zanni MV, Johnsen S, Rasheed S, Makimura H, Lee H, Khor VK, Ahima RS, Grinspoon SK. TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome. J Clin Endocrinol Metab. 2011 Jan; 96(1):E146-50. PMID: 21047923.
    Citations: 72     Fields:    Translation:Humans
  46. Zanni MV, Stanley TL, Makimura H, Chen CY, Grinspoon SK. Effects of TNF-alpha antagonism on E-selectin in obese subjects with metabolic dysregulation. Clin Endocrinol (Oxf). 2010 Jul; 73(1):48-54. PMID: 19878508.
    Citations: 5     Fields:    Translation:Humans
  47. Kan HY, Georgopoulos S, Zanni M, Shkodrani A, Tzatsos A, Xie HX, Zannis VI. Contribution of the hormone-response elements of the proximal ApoA-I promoter, ApoCIII enhancer, and C/EBP binding site of the proximal ApoA-I promoter to the hepatic and intestinal expression of the ApoA-I and ApoCIII genes in transgenic mice. Biochemistry. 2004 May 04; 43(17):5084-93. PMID: 15109267.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  48. Zannis VI, Liu T, Zanni M, Kan HY, Kardassis D. Regulatory gene mutations affecting apolipoprotein gene expression: functions and regulatory behavior of known genes may guide future pharmacogenomic approaches to therapy. Clin Chem Lab Med. 2003 Apr; 41(4):411-24. PMID: 12747582.
    Citations:    Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.