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Thomas Steve Deisboeck, M.D.


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  1. U56CA113004 (DEISBOECK, THOMAS S) Sep 30, 2004 - Feb 28, 2010
    Development of Virtual Tumor
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kaniadakis G, Baldi MM, Deisboeck TS, Grisolia G, Hristopulos DT, Scarfone AM, Sparavigna A, Wada T, Lucia U. The ?-statistics approach to epidemiology. Sci Rep. 2020 11 17; 10(1):19949. PMID: 33203913; PMCID: PMC7673996.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  2. Wang Z, Deisboeck TS. Dynamic Targeting in Cancer Treatment. Front Physiol. 2019; 10:96. PMID: 30890944; PMCID: PMC6413712.
    Citations: 9     
  3. Lucia U, Deisboeck TS. The importance of ion fluxes for cancer proliferation and metastasis: A thermodynamic analysis. J Theor Biol. 2018 05 14; 445:1-8. PMID: 29474857.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Boujelben A, Watson M, McDougall S, Yen YF, Gerstner ER, Catana C, Deisboeck T, Batchelor TT, Boas D, Rosen B, Kalpathy-Cramer J, Chaplain MA. Multimodality imaging and mathematical modelling of drug delivery to glioblastomas. Interface Focus. 2016 Oct 06; 6(5):20160039. PMID: 27708763; PMCID: PMC4992742.
    Citations: 15     
  5. Lucia U, Ponzetto A, Deisboeck TS. Constructal approach to cell membranes transport: Amending the 'Norton-Simon' hypothesis for cancer treatment. Sci Rep. 2016 Jan 29; 6:19451. PMID: 26822208.
    Citations: 2     Fields:    Translation:Cells
  6. Wang Z, Butner JD, Cristini V, Deisboeck TS. Integrated PK-PD and agent-based modeling in oncology. J Pharmacokinet Pharmacodyn. 2015 Apr; 42(2):179-89. PMID: 25588379.
    Citations: 27     Fields:    Translation:Humans
  7. Johnson D, Connor AJ, McKeever S, Wang Z, Deisboeck TS, Quaiser T, Shochat E. Semantically linking in silico cancer models. Cancer Inform. 2014; 13(Suppl 1):133-43. PMID: 25520553; PMCID: PMC4260769.
    Citations: 5     
  8. Lucia U, Ponzetto A, Deisboeck TS. A thermo-physical analysis of the proton pump vacuolar-ATPase: the constructal approach. Sci Rep. 2014 Oct 24; 4:6763. PMID: 25342534.
    Citations: 7     Fields:    
  9. Wang Z, Deisboeck TS, Cristini V. Development of a sampling-based global sensitivity analysis workflow for multiscale computational cancer models. IET Syst Biol. 2014 Oct; 8(5):191-7. PMID: 25257020; PMCID: PMC4180114.
    Citations: 15     Fields:    Translation:HumansCells
  10. Wang Z, Butner JD, Kerketta R, Cristini V, Deisboeck TS. Simulating cancer growth with multiscale agent-based modeling. Semin Cancer Biol. 2015 Feb; 30:70-8. PMID: 24793698; PMCID: PMC4216775.
    Citations: 80     Fields:    Translation:Humans
  11. Wang Z, Deisboeck TS. Mathematical modeling in cancer drug discovery. Drug Discov Today. 2014 Feb; 19(2):145-50. PMID: 23831857.
    Citations: 30     Fields:    Translation:HumansAnimals
  12. Johnson D, McKeever S, Stamatakos G, Dionysiou D, Graf N, Sakkalis V, Marias K, Wang Z, Deisboeck TS. Dealing with diversity in computational cancer modeling. Cancer Inform. 2013; 12:115-24. PMID: 23700360.
    Citations: 5     
  13. Wang Z, Sagotsky J, Taylor T, Shironoshita P, Deisboeck TS. Accelerating cancer systems biology research through Semantic Web technology. Wiley Interdiscip Rev Syst Biol Med. 2013 Mar-Apr; 5(2):135-51. PMID: 23188758.
    Citations: 7     Fields:    Translation:Humans
  14. Sfakianakis S, Sakkalis V, Marias K, Stamatakos G, McKeever S, Deisboeck TS, Graf N. An architecture for integrating cancer model repositories. Annu Int Conf IEEE Eng Med Biol Soc. 2012; 2012:6628-31. PMID: 23367449.
    Citations: 1     Fields:    Translation:Humans
  15. Deisboeck TS, Wang Z, Macklin P, Cristini V. Multiscale cancer modeling. Annu Rev Biomed Eng. 2011 Aug 15; 13:127-55. PMID: 21529163.
    Citations: 120     Fields:    Translation:Humans
  16. Wang Z, Bordas V, Deisboeck TS. Identification of Critical Molecular Components in a Multiscale Cancer Model Based on the Integration of Monte Carlo, Resampling, and ANOVA. Front Physiol. 2011; 2:35. PMID: 21779251.
    Citations: 18     
  17. Wang Z, Bordas V, Deisboeck TS. Discovering Molecular Targets in Cancer with Multiscale Modeling. Drug Dev Res. 2011 Feb 01; 72(1):45-52. PMID: 21572568.
    Citations: 7     Fields:    
  18. Wang Z, Bordas V, Sagotsky J, Deisboeck TS. Identifying therapeutic targets in a combined EGFR-TGFßR signalling cascade using a multiscale agent-based cancer model. Math Med Biol. 2012 Mar; 29(1):95-108. PMID: 21147846.
    Citations: 17     Fields:    Translation:HumansCells
  19. Deisboeck TS, Sagotsky J. Professional networks in the life sciences: linking the linked. Cancer Inform. 2010 Aug 25; 9:189-95. PMID: 20838607.
    Citations: 1     
  20. Chen LL, Ulmer S, Deisboeck TS. An agent-based model identifies MRI regions of probable tumor invasion in a patient with glioblastoma. Phys Med Biol. 2010 Jan 21; 55(2):329-38. PMID: 20019405.
    Citations: 2     Fields:    Translation:Humans
  21. Castorina P, Carcò D, Guiot C, Deisboeck TS. Tumor growth instability and its implications for chemotherapy. Cancer Res. 2009 Nov 01; 69(21):8507-15. PMID: 19861540.
    Citations: 11     Fields:    Translation:Humans
  22. Chen LL, Blumm N, Christakis NA, Barabási AL, Deisboeck TS. Cancer metastasis networks and the prediction of progression patterns. Br J Cancer. 2009 Sep 01; 101(5):749-58. PMID: 19707203.
    Citations: 33     Fields:    Translation:Humans
  23. Wang Z, Birch CM, Sagotsky J, Deisboeck TS. Cross-scale, cross-pathway evaluation using an agent-based non-small cell lung cancer model. Bioinformatics. 2009 Sep 15; 25(18):2389-96. PMID: 19578172.
    Citations: 36     Fields:    Translation:Cells
  24. Deisboeck TS. Personalizing medicine: a systems biology perspective. Mol Syst Biol. 2009; 5:249. PMID: 19293829.
    Citations: 23     Fields:    Translation:HumansPHPublic Health
  25. Zhang L, Chen LL, Deisboeck TS. Multi-scale, multi-resolution brain cancer modeling. Math Comput Simul. 2009 Mar 01; 79(7):2021-2035. PMID: 20161556.
    Citations: 7     
  26. Yoon J, Deisboeck TS. Investigating differential dynamics of the MAPK signaling cascade using a multi-parametric global sensitivity analysis. PLoS One. 2009; 4(2):e4560. PMID: 19234599.
    Citations: 15     Fields:    Translation:HumansCells
  27. Deisboeck TS, Couzin ID. Collective behavior in cancer cell populations. Bioessays. 2009 Feb; 31(2):190-7. PMID: 19204991.
    Citations: 60     Fields:    Translation:HumansAnimals
  28. Zhang L, Strouthos CG, Wang Z, Deisboeck TS. Simulating Brain Tumor Heterogeneity with a Multiscale Agent-Based Model: Linking Molecular Signatures, Phenotypes and Expansion Rate. Math Comput Model. 2009 Jan 01; 49(1-2):307-319. PMID: 20047002.
    Citations: 40     
  29. Deisboeck TS, Wang Z. A new concept for cancer therapy: out-competing the aggressor. Cancer Cell Int. 2008 Dec 12; 8:19. PMID: 19077276.
  30. Chen LL, Zhang L, Yoon J, Deisboeck TS. Cancer cell motility: optimizing spatial search strategies. Biosystems. 2009 Mar; 95(3):234-42. PMID: 19056461.
    Citations: 2     Fields:    Translation:Cells
  31. Dattoli G, Guiot C, Delsanto PP, Ottaviani PL, Pagnutti S, Deisboeck TS. Cancer metabolism and the dynamics of metastasis. J Theor Biol. 2009 Feb 07; 256(3):305-10. PMID: 18996401.
    Citations: 5     Fields:    Translation:HumansAnimals
  32. Deisboeck TS, Zhang L, Yoon J, Costa J. In silico cancer modeling: is it ready for prime time? Nat Clin Pract Oncol. 2009 Jan; 6(1):34-42. PMID: 18852721.
    Citations: 47     Fields:    Translation:Humans
  33. Zhang L, Wang Z, Sagotsky JA, Deisboeck TS. Multiscale agent-based cancer modeling. J Math Biol. 2009 Apr; 58(4-5):545-59. PMID: 18787828.
    Citations: 44     Fields:    Translation:Humans
  34. Sagotsky JA, Zhang L, Wang Z, Martin S, Deisboeck TS. Life Sciences and the web: a new era for collaboration. Mol Syst Biol. 2008; 4:201. PMID: 18594519.
    Citations: 17     Fields:    
  35. Solé RV, Rodríguez-Caso C, Deisboeck TS, Saldaña J. Cancer stem cells as the engine of unstable tumor progression. J Theor Biol. 2008 Aug 21; 253(4):629-37. PMID: 18534628.
    Citations: 9     Fields:    Translation:HumansCells
  36. Deisboeck TS. Cancer: a profit-driven biosystem? Med Hypotheses. 2008 Aug; 71(2):186-9. PMID: 18420354.
    Citations: 2     Fields:    Translation:Humans
  37. Deisboeck TS, Guiot C. Surgical impact on brain tumor invasion: a physical perspective. Ann Surg Innov Res. 2008 Apr 02; 2:1. PMID: 18384681.
    Citations: 1     
  38. Wang Z, Birch CM, Deisboeck TS. Cross-scale sensitivity analysis of a non-small cell lung cancer model: linking molecular signaling properties to cellular behavior. Biosystems. 2008 Jun; 92(3):249-58. PMID: 18448237.
    Citations: 18     Fields:    Translation:Cells
  39. Huang S, Vader D, Wang Z, Stemmer-Rachamimov A, Weitz DA, Dai G, Rosen BR, Deisboeck TS. Using magnetic resonance microscopy to study the growth dynamics of a glioma spheroid in collagen I: A case study. BMC Med Imaging. 2008 Jan 29; 8:3. PMID: 18230155.
    Citations: 6     Fields:    Translation:HumansCells
  40. Wang Z, Zhang L, Sagotsky J, Deisboeck TS. Simulating non-small cell lung cancer with a multiscale agent-based model. Theor Biol Med Model. 2007 Dec 21; 4:50. PMID: 18154660.
    Citations: 42     Fields:    
  41. Guiot C, Pugno N, Delsanto PP, Deisboeck TS. Physical aspects of cancer invasion. Phys Biol. 2007 Dec 17; 4(4):P1-6. PMID: 18185003.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  42. Castorina P, Deisboeck TS, Gabriele P, Guiot C. Growth laws in cancer: implications for radiotherapy. Radiat Res. 2007 Sep; 168(3):349-56. PMID: 17705631.
    Citations: 5     Fields:    Translation:HumansCells
  43. Deisboeck TS, Zhang L, Martin S. Advancing cancer systems biology: introducing the Center for the Development of a Virtual Tumor, CViT. Cancer Inform. 2007; 5:1-8. PMID: 19390664.
    Citations: 16     
  44. Guiot C, Delsanto PP, Deisboeck TS. Morphological instability and cancer invasion: a 'splashing water drop' analogy. Theor Biol Med Model. 2007 Jan 25; 4:4. PMID: 17254360.
    Citations: 6     Fields:    Translation:HumansAnimals
  45. Deisboeck TS, Wang Z. Cancer dissemination: a consequence of limited carrying capacity? Med Hypotheses. 2007; 69(1):173-7. PMID: 17196762; PMCID: PMC2002493.
    Citations: 6     Fields:    Translation:HumansAnimals
  46. Zhang L, Athale CA, Deisboeck TS. Development of a three-dimensional multiscale agent-based tumor model: simulating gene-protein interaction profiles, cell phenotypes and multicellular patterns in brain cancer. J Theor Biol. 2007 Jan 07; 244(1):96-107. PMID: 16949103.
    Citations: 72     Fields:    Translation:HumansCells
  47. Deisboeck TS, Guiot C, Delsanto PP, Pugno N. Does cancer growth depend on surface extension? Med Hypotheses. 2006; 67(6):1338-41. PMID: 16828232.
    Citations: 3     Fields:    Translation:HumansAnimals
  48. Guiot C, Delsanto PP, Carpinteri A, Pugno N, Mansury Y, Deisboeck TS. The dynamic evolution of the power exponent in a universal growth model of tumors. J Theor Biol. 2006 Jun 07; 240(3):459-63. PMID: 16324717.
    Citations: 12     Fields:    Translation:Humans
  49. Castro M, Molina-París C, Deisboeck TS. Tumor growth instability and the onset of invasion. Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Oct; 72(4 Pt 1):041907. PMID: 16383420.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  50. Athale CA, Deisboeck TS. The effects of EGF-receptor density on multiscale tumor growth patterns. J Theor Biol. 2006 Feb 21; 238(4):771-9. PMID: 16126230.
    Citations: 30     Fields:    Translation:HumansCells
  51. Mansury Y, Diggory M, Deisboeck TS. Evolutionary game theory in an agent-based brain tumor model: exploring the 'Genotype-Phenotype' link. J Theor Biol. 2006 Jan 07; 238(1):146-56. PMID: 16081108.
    Citations: 35     Fields:    Translation:Humans
  52. Kaufman LJ, Brangwynne CP, Kasza KE, Filippidi E, Gordon VD, Deisboeck TS, Weitz DA. Glioma expansion in collagen I matrices: analyzing collagen concentration-dependent growth and motility patterns. Biophys J. 2005 Jul; 89(1):635-50. PMID: 15849239; PMCID: PMC1366562.
    Citations: 110     Fields:    Translation:HumansCells
  53. Deisboeck TS, Mansury Y, Guiot C, Degiorgis PG, Delsanto PP. Insights from a novel tumor model: Indications for a quantitative link between tumor growth and invasion. Med Hypotheses. 2005; 65(4):785-90. PMID: 15961253.
    Citations: 7     Fields:    Translation:Humans
  54. Deisboeck TS, Demuth T, Mansury Y. Correlating velocity patterns with spatial dynamics in glioma cell migration. Acta Biotheor. 2005; 53(3):181-90. PMID: 16329007.
    Citations: 4     Fields:    Translation:HumansCells
  55. Athale C, Mansury Y, Deisboeck TS. Simulating the impact of a molecular 'decision-process' on cellular phenotype and multicellular patterns in brain tumors. J Theor Biol. 2005 Apr 21; 233(4):469-81. PMID: 15748909.
    Citations: 33     Fields:    Translation:HumansCells
  56. Solé RV, Deisboeck TS. An error catastrophe in cancer? J Theor Biol. 2004 May 07; 228(1):47-54. PMID: 15064082.
    Citations: 29     Fields:    Translation:AnimalsCells
  57. Zhang S, Bastin ME, Laidlaw DH, Sinha S, Armitage PA, Deisboeck TS. Visualization and analysis of white matter structural asymmetry in diffusion tensor MRI data. Magn Reson Med. 2004 Jan; 51(1):140-7. PMID: 14705054.
    Citations: 9     Fields:    Translation:Humans
  58. Guiot C, Degiorgis PG, Delsanto PP, Gabriele P, Deisboeck TS. Does tumor growth follow a "universal law"? J Theor Biol. 2003 Nov 21; 225(2):147-51. PMID: 14575649.
    Citations: 44     Fields:    Translation:HumansAnimals
  59. Mansury Y, Deisboeck TS. The impact of "search precision" in an agent-based tumor model. J Theor Biol. 2003 Oct 07; 224(3):325-37. PMID: 12941591.
    Citations: 16     Fields:    Translation:Humans
  60. Gordon VD, Valentine MT, Gardel ML, Andor-Ardó D, Dennison S, Bogdanov AA, Weitz DA, Deisboeck TS. Measuring the mechanical stress induced by an expanding multicellular tumor system: a case study. Exp Cell Res. 2003 Sep 10; 289(1):58-66. PMID: 12941604.
    Citations: 37     Fields:    Translation:HumansCells
  61. Deisboeck TS, Wakimoto H, Wakimoto H, Nestler U, Louis DN, Sehgal PK, Simon M, Chiocca EA, Hochberg FH. Development of a novel non-human primate model for preclinical gene vector safety studies. Determining the effects of intracerebral HSV-1 inoculation in the common marmoset: a comparative study. Gene Ther. 2003 Aug; 10(15):1225-33. PMID: 12858187.
    Citations: 5     Fields:    Translation:AnimalsCells
  62. Mansury Y, Kimura M, Lobo J, Deisboeck TS. Emerging patterns in tumor systems: simulating the dynamics of multicellular clusters with an agent-based spatial agglomeration model. J Theor Biol. 2002 Dec 07; 219(3):343-70. PMID: 12419662.
    Citations: 32     Fields:    Translation:HumansAnimals
  63. Sander LM, Deisboeck TS. Growth patterns of microscopic brain tumors. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Nov; 66(5 Pt 1):051901. PMID: 12513517.
    Citations: 31     Fields:    Translation:HumansCells
  64. Mojsilovic A, Rogowitz B, Gomes J, Deisboeck TS. Analysis and 3D reconstruction of heterogeneity in malignant brain tumors: an interdisciplinary case study using a novel computational visualization approach. Anal Quant Cytol Histol. 2002 Jun; 24(3):125-33. PMID: 12102123.
    Citations: 1     Fields:    Translation:HumansCells
  65. Deisboeck TS, Berens ME, Kansal AR, Torquato S, Stemmer-Rachamimov AO, Chiocca EA. Pattern of self-organization in tumour systems: complex growth dynamics in a novel brain tumour spheroid model. Cell Prolif. 2001 Apr; 34(2):115-34. PMID: 11348426; PMCID: PMC6495396.
    Citations: 65     Fields:    Translation:Cells
  66. Kansal AR, Torquato S, Chiocca EA, Deisboeck TS. Emergence of a subpopulation in a computational model of tumor growth. J Theor Biol. 2000 Dec 07; 207(3):431-41. PMID: 11082311.
    Citations: 18     Fields:    Translation:HumansCells
  67. Harsh GR, Deisboeck TS, Louis DN, Hilton J, Colvin M, Silver JS, Qureshi NH, Kracher J, Finkelstein D, Chiocca EA, Hochberg FH. Thymidine kinase activation of ganciclovir in recurrent malignant gliomas: a gene-marking and neuropathological study. J Neurosurg. 2000 May; 92(5):804-11. PMID: 10794295.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  68. Kansal AR, Torquato S, Harsh GR IV, Chiocca EA, Deisboeck TS. Simulated brain tumor growth dynamics using a three-dimensional cellular automaton. J Theor Biol. 2000 Apr 21; 203(4):367-82. PMID: 10736214.
    Citations: 80     Fields:    Translation:HumansCells
  69. Kansal AR, Torquato S, Harsh IV GR, Chiocca EA, Deisboeck TS. Cellular automaton of idealized brain tumor growth dynamics. Biosystems. 2000 Feb; 55(1-3):119-27. PMID: 10745115.
    Citations: 27     Fields:    
  70. Ikeda K, Ichikawa T, Wakimoto H, Wakimoto H, Silver JS, Deisboeck TS, Finkelstein D, Harsh GR, Louis DN, Bartus RT, Hochberg FH, Chiocca EA. Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses. Nat Med. 1999 Aug; 5(8):881-7. PMID: 10426310.
    Citations: 134     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.