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Wendy S. Garrett, M.D., Ph.D.

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Biography
Yale UniversityB.S./ M.S., Combined Bachelor of Science & Master of Science
Yale UniversityPh.D.
Yale University School of MedicineM.D.
Dana-Farber Partners Cancer Care, Laboratory of Laurie H. GlimcherMedical Oncology Fellowship

Overview
Wendy Garrett is the Irene Heinz Given Professor of Immunology and Infectious Diseases in the Departments of Immunology and Infectious Diseases and of Molecular Metabolism at the Harvard Chan School of Public Health, and also has a Professorship in the Departments of Medicine at Harvard Medical School. Dr. Garrett pursued an MD and PhD at Yale University. She completed a fellowship at the Dana-Farber Cancer Institute and postdoctoral training at Harvard University Medical School.

Dr. Garrett investigates host-microbiota interactions in health and disease. Her research team studies the interplay between the gastrointestinal immune system and the gut microbiota in health, inflammatory bowel disease (IBD) and colorectal cancer (CRC). The Garrett lab focuses on how the gut microbiota influence both innate and adaptive populations and the contribution of these cells to immune homeostasis and disease.

Dr. Garrett's team has identified specific species, pathways, and metabolites made by the microbiota that influence health and disease states. The lab also studies microbes and immune cells that are not only instrumental in potentiating carcinogenesis but are integral to intestinal homeostasis. The multi-faceted research approach includes meta'omics, microbiology, cellular immunology, biochemistry, cell biology, and cancer biology. The lab uses mouse models, human specimens, and primary and transformed mammalian cells and bacterial cells in their experiments in order to move facilely between large human data sets and in vivo and in vitro model systems with a core mission of determining basic biologic mechanism and applying the findings to precision medicine.

The Garrett lab is highly collaborative and works with many laboratories at institutions in the greater Boston area, in Harvard-affiliated hospitals and institutes, and at national and international research centers.

Mentoring
Colonic FoxP3+ Treg Transcriptional Responses to Short Chain Fatty Acids
Summer, 06/10/13 - 08/30/13

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA243454 (CHAN, ANDREW T) Jun 1, 2020 - May 31, 2025
    NIH
    Prebiotic effect of eicosapentaenoic acid treatment for colorectal cancer
    Role: Co-Principal Investigator
  2. R01DK113599 (LESSER, CAMMIE) Sep 23, 2016 - Aug 31, 2021
    NIH
    Designer Probiotics for the treatment of intestinal infection and inflammation
    Role: Principal Investigator
  3. R01CA202704 (CHAN, ANDREW T) Mar 1, 2016 - Feb 28, 2021
    NIH
    Dietary sulfur, the gut microbiome, and colorectal cancer
    Role: Co-Principal Investigator
  4. R21AA023207 (GARRETT, WENDY S.) Mar 10, 2015 - Jul 31, 2017
    NIH
    The gut microbiota and ethanol
    Role: Principal Investigator
  5. R01CA154426 (GARRETT, WENDY S.) Mar 18, 2011 - Jul 31, 2022
    NIH
    Colorectal carcinogenesis and Fusobacterium nucleatum: oncomicrobe, oncometabolites, and oncoimmunology
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Everett C, Li C, Wilkinson JE, Nguyen LH, McIver LJ, Ivey K, Izard J, Palacios N, Eliassen AH, Willett WC, Ascherio A, Sun Q, Tworoger SS, Chan AT, Garrett WS, Huttenhower C, Rimm EB, Song M. Overview of the Microbiome Among Nurses study (Micro-N) as an example of prospective characterization of the microbiome within cohort studies. Nat Protoc. 2021 Apr 21. PMID: 33883746.
    Citations:    Fields:    
  2. Garrett WS. Microbial Nourishment for Undernutrition. N Engl J Med. 2021 04 22; 384(16):1566-1567. PMID: 33826813.
    Citations:    Fields:    Translation:HumansAnimals
  3. Brennan CA, Nakatsu G, Gallini Comeau CA, Drew DA, Glickman JN, Schoen RE, Chan AT, Garrett WS. Aspirin Modulation of the Colorectal Cancer-Associated Microbe Fusobacterium nucleatum. mBio. 2021 04 06; 12(2). PMID: 33824205.
    Citations:    Fields:    
  4. Wilkinson JE, Franzosa EA, Everett C, Li C, Hu FB, Wirth DF, Song M, Chan AT, Rimm E, Garrett WS, Huttenhower C. A framework for microbiome science in public health. Nat Med. 2021 Apr 05. PMID: 33820996.
    Citations: 1     Fields:    
  5. Borowsky J, Haruki K, Lau MC, Dias Costa A, Väyrynen JP, Ugai T, Arima K, da Silva A, Felt KD, Zhao M, Gurjao C, Twombly TS, Fujiyoshi K, Väyrynen SA, Hamada T, Mima K, Bullman S, Harrison TA, Phipps AI, Peters U, Ng K, Meyerhardt JA, Song M, Giovannucci EL, Wu K, Zhang X, Freeman GJ, Huttenhower C, Garrett WS, Chan AT, Leggett BA, Whitehall VLJ, Walker N, Brown I, Bettington M, Nishihara R, Fuchs CS, Lennerz JK, Giannakis M, Nowak JA, Ogino S. Association of Fusobacterium nucleatum with Specific T-cell Subsets in the Colorectal Carcinoma Microenvironment. Clin Cancer Res. 2021 Feb 25. PMID: 33632927.
    Citations:    Fields:    
  6. Lobel L, Cao YG, Fenn K, Glickman JN, Garrett WS. Diet posttranslationally modifies the mouse gut microbial proteome to modulate renal function. Science. 2020 09 18; 369(6510):1518-1524. PMID: 32943527.
    Citations: 4     Fields:    Translation:AnimalsCells
  7. Abed J, Maalouf N, Manson AL, Earl AM, Parhi L, Emgård JEM, Klutstein M, Tayeb S, Almogy G, Atlan KA, Chaushu S, Israeli E, Mandelboim O, Garrett WS, Bachrach G. Colon Cancer-Associated Fusobacterium nucleatum May Originate From the Oral Cavity and Reach Colon Tumors via the Circulatory System. Front Cell Infect Microbiol. 2020; 10:400. PMID: 32850497.
    Citations: 7     Fields:    
  8. Knudsen NH, Stanya KJ, Hyde AL, Chalom MM, Alexander RK, Liou YH, Starost KA, Gangl MR, Jacobi D, Liu S, Sopariwala DH, Fonseca-Pereira D, Li J, Hu FB, Garrett WS, Narkar VA, Ortlund EA, Kim JH, Paton CM, Cooper JA, Lee CH. Interleukin-13 drives metabolic conditioning of muscle to endurance exercise. Science. 2020 05 01; 368(6490). PMID: 32355002.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  9. Yan Y, Drew DA, Markowitz A, Lloyd-Price J, Abu-Ali G, Nguyen LH, Tran C, Chung DC, Gilpin KK, Meixell D, Parziale M, Schuck M, Patel Z, Richter JM, Kelsey PB, Garrett WS, Chan AT, Stadler ZK, Huttenhower C. Structure of the Mucosal and Stool Microbiome in Lynch Syndrome. Cell Host Microbe. 2020 04 08; 27(4):585-600.e4. PMID: 32240601.
    Citations: 6     Fields:    Translation:HumansCells
  10. Garrett WS. Enterococcus in Graft-versus-Host Disease. N Engl J Med. 2020 03 12; 382(11):1064-1066. PMID: 32160669.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  11. Haruki K, Kosumi K, Hamada T, Twombly TS, Väyrynen JP, Kim SA, Masugi Y, Qian ZR, Mima K, Baba Y, da Silva A, Borowsky J, Arima K, Fujiyoshi K, Lau MC, Li P, Guo C, Chen Y, Song M, Nowak JA, Nishihara R, Yanaga K, Zhang X, Wu K, Bullman S, Garrett WS, Huttenhower C, Meyerhardt JA, Giannakis M, Chan AT, Fuchs CS, Ogino S. Association of autophagy status with amount of Fusobacterium nucleatum in colorectal cancer. J Pathol. 2020 04; 250(4):397-408. PMID: 31880318.
    Citations: 4     Fields:    Translation:HumansCells
  12. Garrett WS. Immune recognition of microbial metabolites. Nat Rev Immunol. 2020 02; 20(2):91-92. PMID: 31768024.
    Citations: 6     Fields:    Translation:HumansCells
  13. Howitt MR, Cao YG, Gologorsky MB, Li JA, Haber AL, Biton M, Lang J, Michaud M, Regev A, Garrett WS. The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis. Immunohorizons. 2020 01 24; 4(1):23-32. PMID: 31980480.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Nguyen LH, Ma W, Wang DD, Cao Y, Mallick H, Gerbaba TK, Lloyd-Price J, Abu-Ali G, Hall AB, Sikavi D, Drew DA, Mehta RS, Arze C, Joshi AD, Yan Y, Branck T, DuLong C, Ivey KL, Ogino S, Rimm EB, Song M, Garrett WS, Izard J, Huttenhower C, Chan AT. Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men. Gastroenterology. 2020 04; 158(5):1313-1325. PMID: 31972239.
    Citations: 7     Fields:    Translation:HumansCells
  15. Lavoie S, Chun E, Bae S, Brennan CA, Gallini Comeau CA, Lang JK, Michaud M, Hoveyda HR, Fraser GL, Fuller MH, Layden BT, Glickman JN, Garrett WS. Expression of Free Fatty Acid Receptor 2 by Dendritic Cells Prevents Their Expression of Interleukin 27 and Is Required for Maintenance of Mucosal Barrier and Immune Response Against Colorectal Tumors in Mice. Gastroenterology. 2020 04; 158(5):1359-1372.e9. PMID: 31917258.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  16. Chun E, Lavoie S, Fonseca-Pereira D, Bae S, Michaud M, Hoveyda HR, Fraser GL, Gallini Comeau CA, Glickman JN, Fuller MH, Layden BT, Garrett WS. Metabolite-Sensing Receptor Ffar2 Regulates Colonic Group 3 Innate Lymphoid Cells and Gut Immunity. Immunity. 2019 11 19; 51(5):871-884.e6. PMID: 31628054.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  17. Garrett WS. The gut microbiota and colon cancer. Science. 2019 06 21; 364(6446):1133-1135. PMID: 31221845.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  18. Elinav E, Garrett WS, Trinchieri G, Wargo J. The cancer microbiome. Nat Rev Cancer. 2019 07; 19(7):371-376. PMID: 31186547.
    Citations: 27     Fields:    Translation:Humans
  19. Pizarro TT, Stappenbeck TS, Rieder F, Rosen MJ, Colombel JF, Donowitz M, Towne J, Mazmanian SK, Faith JJ, Hodin RA, Garrett WS, Fichera A, Poritz LS, Cortes CJ, Shtraizent N, Honig G, Snapper SB, Hurtado-Lorenzo A, Salzman NH, Chang EB. Challenges in IBD Research: Preclinical Human IBD Mechanisms. Inflamm Bowel Dis. 2019 05 16; 25(Suppl 2):S5-S12. PMID: 31095706.
    Citations: 6     Fields:    Translation:HumansAnimals
  20. Brennan CA, Garrett WS. Fusobacterium nucleatum - symbiont, opportunist and oncobacterium. Nat Rev Microbiol. 2019 03; 17(3):156-166. PMID: 30546113.
    Citations: 81     Fields:    Translation:HumansCells
  21. Lobel L, Garrett WS. Butyrate Makes Macrophages "Go Nuclear" against Bacterial Pathogens. Immunity. 2019 02 19; 50(2):275-278. PMID: 30784572.
    Citations: 1     Fields:    Translation:Cells
  22. Wilson MR, Jiang Y, Villalta PW, Stornetta A, Boudreau PD, Carrá A, Brennan CA, Chun E, Ngo L, Samson LD, Engelward BP, Garrett WS, Balbo S, Balskus EP. The human gut bacterial genotoxin colibactin alkylates DNA. Science. 2019 02 15; 363(6428). PMID: 30765538.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  23. Yang W, Liu L, Keum N, Qian ZR, Nowak JA, Hamada T, Song M, Cao Y, Nosho K, Smith-Warner SA, Zhang S, Masugi Y, Ng K, Kosumi K, Ma Y, Garrett WS, Wang M, Nan H, Giannakis M, Meyerhardt JA, Chan AT, Fuchs CS, Nishihara R, Wu K, Giovannucci EL, Ogino S, Zhang X. Calcium Intake and Risk of Colorectal Cancer According to Tumor-infiltrating T Cells. Cancer Prev Res (Phila). 2019 05; 12(5):283-294. PMID: 30760501.
    Citations: 1     Fields:    Translation:HumansCells
  24. Lavoie S, Conway KL, Lassen KG, Jijon HB, Pan H, Chun E, Michaud M, Lang JK, Gallini Comeau CA, Dreyfuss JM, Glickman JN, Vlamakis H, Ananthakrishnan A, Kostic A, Garrett WS, Xavier RJ. The Crohn's disease polymorphism, ATG16L1 T300A, alters the gut microbiota and enhances the local Th1/Th17 response. Elife. 2019 01 22; 8. PMID: 30666959.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  25. Hsu T, Gemmell MR, Franzosa EA, Berry S, Mukhopadhya I, Hansen R, Michaud M, Nielsen H, Miller WG, Nielsen H, Bajaj-Elliott M, Huttenhower C, Garrett WS, Hold GL. Comparative genomics and genome biology of Campylobacter showae. Emerg Microbes Infect. 2019; 8(1):827-840. PMID: 31169073.
    Citations: 2     Fields:    Translation:HumansCells
  26. Lavoie S, Garrett WS. The Unfolding Story of ATF6, Microbial Dysbiosis, and Colorectal Cancer. Gastroenterology. 2018 11; 155(5):1309-1311. PMID: 30300614.
    Citations: 5     Fields:    Translation:Humans
  27. Kosumi K, Hamada T, Koh H, Borowsky J, Bullman S, Twombly TS, Nevo D, Masugi Y, Liu L, da Silva A, Chen Y, Du C, Gu M, Li C, Li W, Liu H, Shi Y, Mima K, Song M, Nosho K, Nowak JA, Nishihara R, Baba H, Zhang X, Wu K, Wang M, Huttenhower C, Garrett WS, Meyerson ML, Lennerz JK, Giannakis M, Chan AT, Meyerhardt JA, Fuchs CS, Ogino S. The Amount of Bifidobacterium Genus in Colorectal Carcinoma Tissue in Relation to Tumor Characteristics and Clinical Outcome. Am J Pathol. 2018 12; 188(12):2839-2852. PMID: 30243655.
    Citations: 12     Fields:    Translation:HumansCells
  28. Hamada T, Zhang X, Mima K, Bullman S, Sukawa Y, Nowak JA, Kosumi K, Masugi Y, Twombly TS, Cao Y, Song M, Liu L, da Silva A, Shi Y, Gu M, Li W, Koh H, Nosho K, Inamura K, Keum N, Wu K, Meyerhardt JA, Kostic AD, Huttenhower C, Garrett WS, Meyerson M, Giovannucci EL, Chan AT, Fuchs CS, Nishihara R, Giannakis M, Ogino S. Fusobacterium nucleatum in Colorectal Cancer Relates to Immune Response Differentially by Tumor Microsatellite Instability Status. Cancer Immunol Res. 2018 11; 6(11):1327-1336. PMID: 30228205.
    Citations: 29     Fields:    Translation:HumansCells
  29. Liu L, Tabung FK, Zhang X, Nowak JA, Qian ZR, Hamada T, Nevo D, Bullman S, Mima K, Kosumi K, da Silva A, Song M, Cao Y, Twombly TS, Shi Y, Liu H, Gu M, Koh H, Li W, Du C, Chen Y, Li C, Li W, Mehta RS, Wu K, Wang M, Kostic AD, Giannakis M, Garrett WS, Hutthenhower C, Chan AT, Fuchs CS, Nishihara R, Ogino S, Giovannucci EL. Diets That Promote Colon Inflammation Associate With Risk of Colorectal Carcinomas That Contain Fusobacterium nucleatum. Clin Gastroenterol Hepatol. 2018 10; 16(10):1622-1631.e3. PMID: 29702299.
    Citations: 24     Fields:    Translation:HumansCells
  30. Ogino S, Nowak JA, Hamada T, Phipps AI, Peters U, Milner DA, Giovannucci EL, Nishihara R, Giannakis M, Garrett WS, Song M. Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine. Gut. 2018 06; 67(6):1168-1180. PMID: 29437869.
    Citations: 45     Fields:    Translation:Humans
  31. Haber AL, Biton M, Rogel N, Herbst RH, Shekhar K, Smillie C, Burgin G, Delorey TM, Howitt MR, Katz Y, Tirosh I, Beyaz S, Dionne D, Zhang M, Raychowdhury R, Garrett WS, Rozenblatt-Rosen O, Shi HN, Yilmaz O, Xavier RJ, Regev A. A single-cell survey of the small intestinal epithelium. Nature. 2017 11 16; 551(7680):333-339. PMID: 29144463.
    Citations: 262     Fields:    Translation:AnimalsCells
  32. Lobel L, Garrett WS. Take DAT, Flu! Immunity. 2017 09 19; 47(3):400-402. PMID: 28930655.
    Citations: 1     Fields:    Translation:Humans
  33. Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 09 15; 357(6356):1156-1160. PMID: 28912244.
    Citations: 166     Fields:    Translation:HumansAnimalsCells
  34. Liu L, Nishihara R, Qian ZR, Tabung FK, Nevo D, Zhang X, Song M, Cao Y, Mima K, Masugi Y, Shi Y, da Silva A, Twombly T, Gu M, Li W, Hamada T, Kosumi K, Inamura K, Nowak JA, Drew DA, Lochhead P, Nosho K, Wu K, Wang M, Garrett WS, Chan AT, Fuchs CS, Giovannucci EL, Ogino S. Association Between Inflammatory Diet Pattern and Risk of Colorectal Carcinoma Subtypes Classified by Immune Responses to Tumor. Gastroenterology. 2017 12; 153(6):1517-1530.e14. PMID: 28865736.
    Citations: 22     Fields:    Translation:HumansCells
  35. Yasuda K, Hsu T, Gallini CA, Mclver LJ, Schwager E, Shi A, DuLong CR, Schwager RN, Abu-Ali GS, Franzosa EA, Garrett WS, Huttenhower C, Morgan XC. Fluoride Depletes Acidogenic Taxa in Oral but Not Gut Microbial Communities in Mice. mSystems. 2017 Jul-Aug; 2(4). PMID: 28808691.
    Citations: 4     
  36. Lavoie S, Garrett WS. Fighting Fire with Fiber: Preventing T Cell Infiltration in Diabetes. Cell Metab. 2017 Jul 05; 26(1):8-10. PMID: 28683297.
    Citations:    Fields:    Translation:HumansAnimalsCells
  37. Mehta RS, Nishihara R, Cao Y, Song M, Mima K, Qian ZR, Nowak JA, Kosumi K, Hamada T, Masugi Y, Bullman S, Drew DA, Kostic AD, Fung TT, Garrett WS, Huttenhower C, Wu K, Meyerhardt JA, Zhang X, Willett WC, Giovannucci EL, Fuchs CS, Chan AT, Ogino S. Association of Dietary Patterns With Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue. JAMA Oncol. 2017 Jul 01; 3(7):921-927. PMID: 28125762.
    Citations: 66     Fields:    Translation:HumansCells
  38. Cao Y, Wu K, Mehta R, Drew DA, Song M, Lochhead P, Nguyen LH, Izard J, Fuchs CS, Garrett WS, Huttenhower C, Ogino S, Giovannucci EL, Chan AT. Long-term use of antibiotics and risk of colorectal adenoma. Gut. 2018 04; 67(4):672-678. PMID: 28377387.
    Citations: 49     Fields:    Translation:Humans
  39. Kosumi K, Masugi Y, Yang J, Qian ZR, Kim SA, Li W, Shi Y, da Silva A, Hamada T, Liu L, Gu M, Twombly TS, Cao Y, Barbie DA, Nosho K, Baba H, Garrett WS, Meyerhardt JA, Giovannucci EL, Chan AT, Fuchs CS, Ogino S, Nishihara R. Tumor SQSTM1 (p62) expression and T cells in colorectal cancer. Oncoimmunology. 2017; 6(3):e1284720. PMID: 28405513.
    Citations: 3     
  40. Garrett WS. Gut microbiota in 2016: A banner year for gut microbiota research. Nat Rev Gastroenterol Hepatol. 2017 02; 14(2):78-80. PMID: 28074073.
    Citations: 1     Fields:    Translation:Humans
  41. Rooks MG, Veiga P, Reeves AZ, Lavoie S, Yasuda K, Asano Y, Yoshihara K, Michaud M, Wardwell-Scott L, Gallini CA, Glickman JN, Sudo N, Huttenhower C, Lesser CF, Garrett WS. QseC inhibition as an antivirulence approach for colitis-associated bacteria. Proc Natl Acad Sci U S A. 2017 01 03; 114(1):142-147. PMID: 27980034.
    Citations: 15     Fields:    Translation:AnimalsCells
  42. Yan J, Herzog JW, Tsang K, Brennan CA, Bower MA, Garrett WS, Sartor BR, Aliprantis AO, Charles JF. Gut microbiota induce IGF-1 and promote bone formation and growth. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):E7554-E7563. PMID: 27821775.
    Citations: 110     Fields:    Translation:Animals
  43. Mima K, Cao Y, Chan AT, Qian ZR, Nowak JA, Masugi Y, Shi Y, Song M, da Silva A, Gu M, Li W, Hamada T, Kosumi K, Hanyuda A, Liu L, Kostic AD, Giannakis M, Bullman S, Brennan CA, Milner DA, Baba H, Garraway LA, Meyerhardt JA, Garrett WS, Huttenhower C, Meyerson M, Giovannucci EL, Fuchs CS, Nishihara R, Ogino S. Fusobacterium nucleatum in Colorectal Carcinoma Tissue According to Tumor Location. Clin Transl Gastroenterol. 2016 Nov 03; 7(11):e200. PMID: 27811909.
    Citations: 74     Fields:    
  44. Brennan CA, Garrett WS. Gut Microbiota, Inflammation, and Colorectal Cancer. Annu Rev Microbiol. 2016 09 08; 70:395-411. PMID: 27607555.
    Citations: 119     Fields:    Translation:HumansAnimals
  45. Song M, Nishihara R, Cao Y, Chun E, Qian ZR, Mima K, Inamura K, Masugi Y, Nowak JA, Nosho K, Wu K, Wang M, Giovannucci E, Garrett WS, Fuchs CS, Ogino S, Chan AT. Marine ?-3 Polyunsaturated Fatty Acid Intake and Risk of Colorectal Cancer Characterized by Tumor-Infiltrating T Cells. JAMA Oncol. 2016 Sep 01; 2(9):1197-206. PMID: 27148825.
    Citations: 29     Fields:    Translation:HumansCells
  46. Abed J, Emgård JE, Zamir G, Faroja M, Almogy G, Grenov A, Sol A, Naor R, Pikarsky E, Atlan KA, Mellul A, Chaushu S, Manson AL, Earl AM, Ou N, Brennan CA, Garrett WS, Bachrach G. Fap2 Mediates Fusobacterium nucleatum Colorectal Adenocarcinoma Enrichment by Binding to Tumor-Expressed Gal-GalNAc. . 2016 Aug 10; 20(2):215-25. PMID: 27512904.
    Citations: 123     Translation:HumansAnimalsCells
  47. Cao Y, Nishihara R, Qian ZR, Song M, Mima K, Inamura K, Nowak JA, Drew DA, Lochhead P, Nosho K, Morikawa T, Zhang X, Wu K, Wang M, Garrett WS, Giovannucci EL, Fuchs CS, Chan AT, Ogino S. Regular Aspirin Use Associates With Lower Risk of Colorectal Cancers With Low Numbers of Tumor-Infiltrating Lymphocytes. Gastroenterology. 2016 11; 151(5):879-892.e4. PMID: 27475305.
    Citations: 24     Fields:    Translation:HumansCells
  48. Rooks MG, Garrett WS. Gut microbiota, metabolites and host immunity. Nat Rev Immunol. 2016 05 27; 16(6):341-52. PMID: 27231050.
    Citations: 465     Fields:    Translation:HumansAnimals
  49. Segata N, Baldini F, Pompon J, Garrett WS, Truong DT, Dabiré RK, Diabaté A, Levashina EA, Catteruccia F. The reproductive tracts of two malaria vectors are populated by a core microbiome and by gender- and swarm-enriched microbial biomarkers. Sci Rep. 2016 Apr 18; 6:24207. PMID: 27086581.
    Citations: 27     Fields:    Translation:AnimalsCells
  50. Zhang C, Derrien M, Levenez F, Brazeilles R, Ballal SA, Kim J, Degivry MC, Quéré G, Garault P, van Hylckama Vlieg JE, Garrett WS, Doré J, Veiga P. Ecological robustness of the gut microbiota in response to ingestion of transient food-borne microbes. ISME J. 2016 09; 10(9):2235-45. PMID: 26953599.
    Citations: 39     Fields:    Translation:AnimalsCells
  51. Howitt MR, Lavoie S, Michaud M, Blum AM, Tran SV, Weinstock JV, Gallini CA, Redding K, Margolskee RF, Osborne LC, Artis D, Garrett WS. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science. 2016 Mar 18; 351(6279):1329-33. PMID: 26847546.
    Citations: 205     Fields:    Translation:AnimalsCells
  52. Mima K, Nishihara R, Qian ZR, Cao Y, Sukawa Y, Nowak JA, Yang J, Dou R, Masugi Y, Song M, Kostic AD, Giannakis M, Bullman S, Milner DA, Baba H, Giovannucci EL, Garraway LA, Freeman GJ, Dranoff G, Garrett WS, Huttenhower C, Meyerson M, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S. Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis. Gut. 2016 12; 65(12):1973-1980. PMID: 26311717.
    Citations: 185     Fields:    Translation:HumansCells
  53. Mima K, Sukawa Y, Nishihara R, Qian ZR, Yamauchi M, Inamura K, Kim SA, Masuda A, Nowak JA, Nosho K, Kostic AD, Giannakis M, Watanabe H, Bullman S, Milner DA, Harris CC, Giovannucci E, Garraway LA, Freeman GJ, Dranoff G, Chan AT, Garrett WS, Huttenhower C, Fuchs CS, Ogino S. Fusobacterium nucleatum and T Cells in Colorectal Carcinoma. JAMA Oncol. 2015 Aug; 1(5):653-61. PMID: 26181352.
    Citations: 145     Fields:    Translation:HumansCells
  54. Garrett WS. From cell biology to the microbiome: An intentional infinite loop. J Cell Biol. 2015 Jul 06; 210(1):7-8. PMID: 26150386.
    Citations: 1     Fields:    Translation:Humans
  55. Chun E, Lavoie S, Michaud M, Gallini CA, Kim J, Soucy G, Odze R, Glickman JN, Garrett WS. CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function. Cell Rep. 2015 Jul 14; 12(2):244-57. PMID: 26146082.
    Citations: 97     Fields:    Translation:HumansAnimalsCells
  56. Ballal SA, Veiga P, Fenn K, Michaud M, Kim JH, Gallini CA, Glickman JN, Quéré G, Garault P, Béal C, Derrien M, Courtin P, Kulakauskas S, Chapot-Chartier MP, van Hylckama Vlieg J, Garrett WS. Host lysozyme-mediated lysis of Lactococcus lactis facilitates delivery of colitis-attenuating superoxide dismutase to inflamed colons. Proc Natl Acad Sci U S A. 2015 Jun 23; 112(25):7803-8. PMID: 26056274.
    Citations: 25     Fields:    Translation:AnimalsCells
  57. Erny D, Hrabe de Angelis AL, Jaitin D, Wieghofer P, Staszewski O, David E, Keren-Shaul H, Mahlakoiv T, Jakobshagen K, Buch T, Schwierzeck V, Utermöhlen O, Chun E, Garrett WS, McCoy KD, Diefenbach A, Staeheli P, Stecher B, Amit I, Prinz M. Host microbiota constantly control maturation and function of microglia in the CNS. Nat Neurosci. 2015 Jul; 18(7):965-77. PMID: 26030851.
    Citations: 492     Fields:    Translation:AnimalsCells
  58. Garrett WS. Cancer and the microbiota. Science. 2015 Apr 03; 348(6230):80-6. PMID: 25838377.
    Citations: 226     Fields:    Translation:Humans
  59. Börnigen D, Moon YS, Rahnavard G, Waldron L, McIver L, Shafquat A, Franzosa EA, Miropolsky L, Sweeney C, Morgan XC, Garrett WS, Huttenhower C. A reproducible approach to high-throughput biological data acquisition and integration. PeerJ. 2015; 3:e791. PMID: 26157642.
    Citations: 7     
  60. Hold GL, Garrett WS. Gut microbiota. Microbiota organization--a key to understanding CRC development. Nat Rev Gastroenterol Hepatol. 2015 Mar; 12(3):128-9. PMID: 25688055.
    Citations: 9     Fields:    Translation:Humans
  61. Gur C, Ibrahim Y, Isaacson B, Yamin R, Abed J, Gamliel M, Enk J, Bar-On Y, Stanietsky-Kaynan N, Coppenhagen-Glazer S, Shussman N, Almogy G, Cuapio A, Hofer E, Mevorach D, Tabib A, Ortenberg R, Markel G, Miklic K, Jonjic S, Brennan CA, Garrett WS, Bachrach G, Mandelboim O. Binding of the Fap2 protein of Fusobacterium nucleatum to human inhibitory receptor TIGIT protects tumors from immune cell attack. Immunity. 2015 Feb 17; 42(2):344-355. PMID: 25680274.
    Citations: 212     Fields:    Translation:HumansAnimalsCells
  62. Song M, Garrett WS, Chan AT. Nutrients, foods, and colorectal cancer prevention. Gastroenterology. 2015 May; 148(6):1244-60.e16. PMID: 25575572.
    Citations: 121     Fields:    Translation:HumansAnimalsPHPublic Health
  63. Panikov NS, Mandalakis M, Dai S, Mulcahy LR, Fowle W, Garrett WS, Karger BL. Near-zero growth kinetics of Pseudomonas putida deduced from proteomic analysis. Environ Microbiol. 2015 Jan; 17(1):215-28. PMID: 25088710.
    Citations: 2     Fields:    Translation:Cells
  64. Franzosa EA, Morgan XC, Segata N, Waldron L, Reyes J, Earl AM, Giannoukos G, Boylan MR, Ciulla D, Gevers D, Izard J, Garrett WS, Chan AT, Huttenhower C. Relating the metatranscriptome and metagenome of the human gut. Proc Natl Acad Sci U S A. 2014 Jun 03; 111(22):E2329-38. PMID: 24843156.
    Citations: 215     Fields:    Translation:HumansCells
  65. Sears CL, Garrett WS. Microbes, microbiota, and colon cancer. . 2014 Mar 12; 15(3):317-28. PMID: 24629338.
    Citations: 229     Translation:Humans
  66. Rooks MG, Veiga P, Wardwell-Scott LH, Tickle T, Segata N, Michaud M, Gallini CA, Beal C, van Hylckama-Vlieg JE, Ballal SA, Morgan XC, Glickman JN, Gevers D, Huttenhower C, Garrett WS. Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission. ISME J. 2014 Jul; 8(7):1403-17. PMID: 24500617.
    Citations: 124     Fields:    Translation:HumansAnimalsCells
  67. Kostic AD, Chun E, Meyerson M, Garrett WS. Microbes and inflammation in colorectal cancer. Cancer Immunol Res. 2013 Sep; 1(3):150-7. PMID: 24777677.
    Citations: 21     Fields:    Translation:Humans
  68. Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, Clancy TE, Chung DC, Lochhead P, Hold GL, El-Omar EM, Brenner D, Fuchs CS, Meyerson M, Garrett WS. Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. . 2013 Aug 14; 14(2):207-15. PMID: 23954159.
    Citations: 519     Translation:HumansAnimalsCells
  69. Bhatt AS, Freeman SS, Herrera AF, Pedamallu CS, Gevers D, Duke F, Jung J, Michaud M, Walker BJ, Young S, Earl AM, Kostic AD, Ojesina AI, Hasserjian R, Ballen KK, Chen YB, Hobbs G, Antin JH, Soiffer RJ, Baden LR, Garrett WS, Hornick JL, Marty FM, Meyerson M. Sequence-based discovery of Bradyrhizobium enterica in cord colitis syndrome. N Engl J Med. 2013 Aug 08; 369(6):517-28. PMID: 23924002.
    Citations: 47     Fields:    Translation:HumansCells
  70. Börnigen D, Morgan XC, Franzosa EA, Ren B, Xavier RJ, Garrett WS, Huttenhower C. Functional profiling of the gut microbiome in disease-associated inflammation. Genome Med. 2013; 5(7):65. PMID: 23906180.
    Citations: 19     Fields:    
  71. Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-Y M, Glickman JN, Garrett WS. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 2013 Aug 02; 341(6145):569-73. PMID: 23828891.
    Citations: 1248     Fields:    Translation:HumansAnimalsCells
  72. Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, Deoliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier GB. Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):E2209-18. PMID: 23716675.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  73. Segata N, Boernigen D, Tickle TL, Morgan XC, Garrett WS, Huttenhower C. Computational meta'omics for microbial community studies. Mol Syst Biol. 2013 May 14; 9:666. PMID: 23670539.
    Citations: 87     Fields:    Translation:HumansCells
  74. Garrett WS. Kwashiorkor and the gut microbiota. N Engl J Med. 2013 May 02; 368(18):1746-7. PMID: 23635056.
    Citations: 8     Fields:    Translation:HumansAnimals
  75. Kostic AD, Howitt MR, Garrett WS. Exploring host-microbiota interactions in animal models and humans. Genes Dev. 2013 Apr 01; 27(7):701-18. PMID: 23592793.
    Citations: 142     Fields:    Translation:HumansAnimals
  76. Howitt MR, Garrett WS. A complex microworld in the gut: gut microbiota and cardiovascular disease connectivity. Nat Med. 2012 Aug; 18(8):1188-9. PMID: 22869188.
    Citations: 26     Fields:    Translation:HumansCells
  77. Shanmugam NK, Ellenbogen S, Trebicka E, Wang L, Mukhopadhyay S, Lacy-Hulbert A, Gallini CA, Garrett WS, Cherayil BJ. Tumor necrosis factor a inhibits expression of the iron regulating hormone hepcidin in murine models of innate colitis. PLoS One. 2012; 7(5):e38136. PMID: 22675442.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  78. Kostic AD, Gevers D, Pedamallu CS, Michaud M, Duke F, Earl AM, Ojesina AI, Jung J, Bass AJ, Tabernero J, Baselga J, Liu C, Shivdasani RA, Ogino S, Birren BW, Huttenhower C, Garrett WS, Meyerson M. Genomic analysis identifies association of Fusobacterium with colorectal carcinoma. Genome Res. 2012 Feb; 22(2):292-8. PMID: 22009990.
    Citations: 606     Fields:    Translation:HumansCells
  79. Segata N, Izard J, Waldron L, Gevers D, Miropolsky L, Garrett WS, Huttenhower C. Metagenomic biomarker discovery and explanation. Genome Biol. 2011 Jun 24; 12(6):R60. PMID: 21702898.
    Citations: 2622     Fields:    Translation:HumansAnimalsCells
  80. Rooks MG, Garrett WS. Bacteria, food, and cancer. F1000 Biol Rep. 2011; 3:12. PMID: 21876723.
    Citations: 9     
  81. Smith PM, Garrett WS. The gut microbiota and mucosal T cells. Front Microbiol. 2011; 2:111. PMID: 21833339.
    Citations: 27     
  82. Ermann J, Garrett WS, Kuchroo J, Rourida K, Glickman JN, Bleich A, Glimcher LH. Severity of innate immune-mediated colitis is controlled by the cytokine deficiency-induced colitis susceptibility-1 (Cdcs1) locus. Proc Natl Acad Sci U S A. 2011 Apr 26; 108(17):7137-41. PMID: 21482794.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  83. Ballal SA, Gallini CA, Segata N, Huttenhower C, Garrett WS. Host and gut microbiota symbiotic factors: lessons from inflammatory bowel disease and successful symbionts. Cell Microbiol. 2011 Apr; 13(4):508-17. PMID: 21314883.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  84. Wardwell LH, Huttenhower C, Garrett WS. Current concepts of the intestinal microbiota and the pathogenesis of infection. Curr Infect Dis Rep. 2011 Feb; 13(1):28-34. PMID: 21308452.
    Citations: 30     
  85. Veiga P, Gallini CA, Beal C, Michaud M, Delaney ML, DuBois A, Khlebnikov A, van Hylckama Vlieg JE, Punit S, Glickman JN, Onderdonk A, Glimcher LH, Garrett WS. Bifidobacterium animalis subsp. lactis fermented milk product reduces inflammation by altering a niche for colitogenic microbes. Proc Natl Acad Sci U S A. 2010 Oct 19; 107(42):18132-7. PMID: 20921388.
    Citations: 85     Fields:    Translation:AnimalsCells
  86. Garrett WS, Gallini CA, Yatsunenko T, Michaud M, DuBois A, Delaney ML, Punit S, Karlsson M, Bry L, Glickman JN, Gordon JI, Onderdonk AB, Glimcher LH. Enterobacteriaceae act in concert with the gut microbiota to induce spontaneous and maternally transmitted colitis. . 2010 Sep 16; 8(3):292-300. PMID: 20833380.
    Citations: 322     Translation:AnimalsCells
  87. Garrett WS, Gordon JI, Glimcher LH. Homeostasis and inflammation in the intestine. Cell. 2010 Mar 19; 140(6):859-70. PMID: 20303876.
    Citations: 234     Fields:    Translation:HumansAnimals
  88. Garrett WS, Punit S, Gallini CA, Michaud M, Zhang D, Sigrist KS, Lord GM, Glickman JN, Glimcher LH. Colitis-associated colorectal cancer driven by T-bet deficiency in dendritic cells. Cancer Cell. 2009 Sep 08; 16(3):208-19. PMID: 19732721.
    Citations: 79     Fields:    Translation:HumansAnimalsCells
  89. Garrett WS, Glimcher LH. T-bet-/- RAG2-/- ulcerative colitis: the role of T-bet as a peacekeeper of host-commensal relationships. Cytokine. 2009 Oct-Nov; 48(1-2):144-7. PMID: 19666230.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  90. Shahabi S, Nathan LM, Chanana C, Garett W, Zheng W, Rutherford TJ. Liver metastasis in a case of adenoid cystic carcinoma of the Bartholin's gland: a rare presentation. Arch Gynecol Obstet. 2009 May; 279(5):747-50. PMID: 18800221.
    Citations: 2     Fields:    Translation:Humans
  91. Garrett WS, Lord GM, Punit S, Lugo-Villarino G, Mazmanian SK, Ito S, Glickman JN, Glimcher LH. Communicable ulcerative colitis induced by T-bet deficiency in the innate immune system. Cell. 2007 Oct 05; 131(1):33-45. PMID: 17923086.
    Citations: 415     Fields:    Translation:HumansAnimalsCells
  92. Trombetta ES, Ebersold M, Garrett W, Pypaert M, Mellman I. Activation of lysosomal function during dendritic cell maturation. Science. 2003 Feb 28; 299(5611):1400-3. PMID: 12610307.
    Citations: 212     Fields:    Translation:AnimalsCells
  93. Chow A, Toomre D, Garrett W, Mellman I. Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane. Nature. 2002 Aug 29; 418(6901):988-94. PMID: 12198549.
    Citations: 115     Fields:    Translation:AnimalsCells
  94. Nagata Y, Ono S, Matsuo M, Gnjatic S, Valmori D, Ritter G, Garrett W, Old LJ, Mellman I. Differential presentation of a soluble exogenous tumor antigen, NY-ESO-1, by distinct human dendritic cell populations. Proc Natl Acad Sci U S A. 2002 Aug 06; 99(16):10629-34. PMID: 12138174.
    Citations: 22     Fields:    Translation:HumansCells
  95. Maric M, Arunachalam B, Phan UT, Dong C, Garrett WS, Cannon KS, Alfonso C, Karlsson L, Flavell RA, Cresswell P. Defective antigen processing in GILT-free mice. Science. 2001 Nov 09; 294(5545):1361-5. PMID: 11701933.
    Citations: 95     Fields:    Translation:AnimalsCellsPHPublic Health
  96. Garrett WS, Chen LM, Kroschewski R, Ebersold M, Turley S, Trombetta S, Galán JE, Mellman I. Developmental control of endocytosis in dendritic cells by Cdc42. Cell. 2000 Aug 04; 102(3):325-34. PMID: 10975523.
    Citations: 128     Fields:    Translation:AnimalsCells
  97. Turley SJ, Inaba K, Garrett WS, Ebersold M, Unternaehrer J, Steinman RM, Mellman I. Transport of peptide-MHC class II complexes in developing dendritic cells. Science. 2000 Apr 21; 288(5465):522-7. PMID: 10775112.
    Citations: 112     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.