Harvard Catalyst Profiles

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Steven Kyle Grinspoon, M.D.

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Mentoring
Available: 07/01/12, Expires: 07/01/20

Our lab studies body composition, and in particular central abdominal fat in the visceral depot. We investigate the clinical consequences in terms of inflammation, dyslipidemia, and insulin resistance, and have been focused on developing strategies to reduce the visceral fat using growth hormone releasing hormone and strategies to reduce inflammation using anti-TNF. The student will learn critical pathophysiology, clinical research skills and participate in data analysis with an eye toward contributing to the publication of a manuscript.

Physiologic investigation of the renin-angiotensin-aldosterone system and associated insulin resistance in HIV-infected patients
Summer, 06/17/13 - 08/09/13
The Effects of Metformin on Insulin Resistance in HIV-positive Patients with Upodystrophy
Part Time, 10/01/99 - 06/01/99
Growth Hormone Dynamics in HIV-Associated Fat Redistribution PASTEUR
Summer, 06/26/00 - 08/31/00

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01AI115711 (GRINSPOON, STEVEN K.) Dec 15, 2014 - Nov 30, 2017
    NIH/NIAID
    Tesamorelin Effects on Liver Fat and Histology in HIV: A Collaborative U01 Grant
    Role: Principal Investigator
  2. U01HL123336 (GRINSPOON, STEVEN K.) Aug 8, 2014 - Apr 30, 2020
    NIH/NHLBI
    REPRIEVE - CCC - Lead Application
    Role: Co-Principal Investigator
  3. R01HL095123 (GRINSPOON, STEVEN KYLE) Aug 15, 2009 - Jun 30, 2014
    NIH/NHLBI
    Inflammatory Mechanisms and Treatment Strategies for Atherosclerosis in HIV
    Role: Principal Investigator
  4. R01HL085268 (GRINSPOON, STEVEN KYLE) Sep 25, 2007 - Mar 31, 2012
    NIH/NHLBI
    Consequences and Treatment of Growth Hormone Deficiency in the Metabolic Syndrome
    Role: Principal Investigator
  5. T32HD052961 (GRINSPOON, STEVEN K) Sep 27, 2005 - Apr 30, 2017
    NIH/NICHD
    Training Program in Nutrition and Metabolism
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fourman LT, Pan CS, Zheng I, Gerard ME, Sheehab A, Lee H, Stanley TL, Grinspoon SK. Association of In Utero HIV Exposure With Obesity and Reactive Airway Disease in HIV-Negative Adolescents and Young Adults. J Acquir Immune Defic Syndr. 2020 Feb 01; 83(2):126-134. PMID: 31738195.
    Citations:    
  2. Srinivasa S, Torriani M, Fitch KV, Maehler P, Iyengar S, Feldpausch M, Cypess AM, Grinspoon SK. Brief Report: Adipogenic Expression of Brown Fat Genes in HIV and HIV-Related Parameters. J Acquir Immune Defic Syndr. 2019 Dec 15; 82(5):491-495. PMID: 31714428.
    Citations:    
  3. Stanley TL, Fourman LT, Feldpausch MN, Purdy J, Zheng I, Pan CS, Aepfelbacher J, Buckless C, Tsao A, Kellogg A, Branch K, Lee H, Liu CY, Corey KE, Chung RT, Torriani M, Kleiner DE, Hadigan CM, Grinspoon SK. Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial. Lancet HIV. 2019 Dec; 6(12):e821-e830. PMID: 31611038.
    Citations:    
  4. Bogorodskaya M, Fitch KV, Burdo TH, Maehler P, Easly RM, Murray GR, Feldpausch M, Adler GK, Grinspoon SK, Srinivasa S. Serum Lipocalin 2 (Neutrophil Gelatinase-Associated Lipocalin) in Relation to Biomarkers of Inflammation and Cardiac Stretch During Activation of the Renin-Angiotensin-Aldosterone System in Human Immunodeficiency Virus. J Infect Dis. 2019 Sep 26; 220(9):1420-1424. PMID: 31298286.
    Citations:    
  5. Foldyna B, Lo J, Mayrhofer T, Grinspoon SK, Hoffmann U, Lu MT. Individual coronary plaque changes on serial CT angiography: Within-patient heterogeneity, natural history, and statin effects in HIV. J Cardiovasc Comput Tomogr. 2019 Aug 21. PMID: 31451438.
    Citations:    
  6. Srinivasa S, Grinspoon SK. Every Minute Counts-The Time Is Now to Understand Predictors of Stroke in HIV. EClinicalMedicine. 2019 Aug; 13:8-9. PMID: 31517256.
    Citations:    
  7. Kearns AC, Liu F, Dai S, Robinson JA, Kiernan E, Tesfaye Cheru L, Peng X, Gordon J, Morgello S, Abuova A, Lo J, Zanni MV, Grinspoon SK, Burdo TH, Qin ??? X. Caspase-1 Activation Is Related With HIV-Associated Atherosclerosis in an HIV Transgenic Mouse Model and HIV Patient Cohort. Arterioscler Thromb Vasc Biol. 2019 Sep; 39(9):1762-1775. PMID: 31315440.
    Citations:    
  8. Godfrey C, Bremer A, Alba D, Apovian C, Koethe JR, Koliwad S, Lewis D, Lo J, McComsey GA, Eckard A, Srinivasa S, Trevillyan J, Palmer C, Grinspoon S. Obesity and Fat Metabolism in Human Immunodeficiency Virus-Infected Individuals: Immunopathogenic Mechanisms and Clinical Implications. J Infect Dis. 2019 Jul 02; 220(3):420-431. PMID: 30893434.
    Citations:    
  9. Feinstein MJ, Hsue PY, Benjamin LA, Bloomfield GS, Currier JS, Freiberg MS, Grinspoon SK, Levin J, Longenecker CT, Post WS. Characteristics, Prevention, and Management of Cardiovascular Disease in People Living With HIV: A Scientific Statement From the American Heart Association. Circulation. 2019 Jul 09; 140(2):e98-e124. PMID: 31154814.
    Citations:    
  10. Ishai A, Osborne MT, Tung B, Wang Y, Hammad B, Patrich T, Oberfeld B, Fayad ZA, Giles JT, Lo J, Shin LM, Grinspoon SK, Koenen KC, Pitman RK, Tawakol A. Amygdalar Metabolic Activity Independently Associates With Progression of Visceral Adiposity. J Clin Endocrinol Metab. 2019 04 01; 104(4):1029-1038. PMID: 30383236.
    Citations:    Fields:    
  11. Zanni MV, Grinspoon SK. Striving to characterize endocrine-metabolic and immune health risks among transgender women with HIV. AIDS. 2019 04 01; 33(5):919-922. PMID: 30882492.
    Citations:    
  12. Grinspoon SK, Fitch KV, Overton ET, Fichtenbaum CJ, Zanni MV, Aberg JA, Malvestutto C, Lu MT, Currier JS, Sponseller CA, Waclawiw M, Alston-Smith B, Cooper-Arnold K, Klingman KL, Desvigne-Nickens P, Hoffmann U, Ribaudo HJ, Douglas PS. Rationale and design of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE). Am Heart J. 2019 06; 212:23-35. PMID: 30928825.
    Citations:    
  13. Hoffmann U, Lu MT, Olalere D, Adami EC, Osborne MT, Ivanov A, Aluru JS, Lee S, Arifovic N, Overton ET, Fichtenbaum CJ, Aberg JA, Alston-Smith B, Klingman KL, Waclawiw M, Burdo TH, Williams KC, Zanni MV, Desvigne-Nickens P, Cooper-Arnold K, Fitch KV, Ribaudo H, Douglas PS, Grinspoon SK. Rationale and design of the Mechanistic Substudy of the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE): Effects of pitavastatin on coronary artery disease and inflammatory biomarkers. Am Heart J. 2019 06; 212:1-12. PMID: 30928823.
    Citations:    
  14. Fourman LT, Kileel EM, Hubbard J, Holmes T, Anderson EJ, Looby SE, Fitch KV, Feldpausch MN, Torriani M, Lo J, Stanley TL, Grinspoon SK. Comparison of visceral fat measurement by dual-energy X-ray absorptiometry to computed tomography in HIV and non-HIV. Nutr Diabetes. 2019 Feb 25; 9(1):6. PMID: 30804324.
    Citations:    
  15. deFilippi CR, Grinspoon SK. Myocardial Dysfunction With Contemporary Management of HIV: Prevalence, Pathophysiology, and Opportunities for Prevention. JACC Heart Fail. 2019 02; 7(2):109-111. PMID: 30704602.
    Citations:    Fields:    
  16. Srinivasa S, Fitch KV, Torriani M, Zanni MV, Defilippi C, Christenson R, Maehler P, Looby SE, Lo J, Grinspoon SK. Relationship of visceral and subcutaneous adipose depots to markers of arterial injury and inflammation among individuals with HIV. AIDS. 2019 02 01; 33(2):229-236. PMID: 30325779.
    Citations:    Fields:    
  17. Cheru LT, Fitch KV, Saylor CF, Lu M, Hoffmann U, Lo J, Grinspoon SK. Mild renal impairment is associated with calcified plaque parameters assessed by computed tomography angiography in people living with HIV. AIDS. 2019 02 01; 33(2):219-227. PMID: 30325774.
    Citations:    Fields:    
  18. Weiss JJ, Sanchez L, Hubbard J, Lo J, Grinspoon SK, Fitch KV. Diet Quality Is Low and Differs by Sex in People with HIV. J Nutr. 2019 01 01; 149(1):78-87. PMID: 30624677.
    Citations:    Fields:    
  19. Adrian S, Scherzinger A, Sanyal A, Lake JE, Falutz J, Dubé MP, Stanley T, Grinspoon S, Mamputu JC, Marsolais C, Brown TT, Erlandson KM. The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV. J Frailty Aging. 2019; 8(3):154-159. PMID: 31237318.
    Citations:    
  20. Mosepele M, Regan S, Massaro J, Meigs JB, Zanni MV, D'Agostino RB, Grinspoon SK, Triant VA. Impact of the American College of Cardiology/American Heart Association Cholesterol Guidelines on Statin Eligibility Among Human Immunodeficiency Virus-Infected Individuals. Open Forum Infect Dis. 2018 Dec; 5(12):ofy326. PMID: 30619912.
    Citations:    
  21. Braun LR, Feldpausch MN, Czerwonka N, Weiss J, Branch K, Lee H, Martinez-Salazar EL, Torriani M, Sponseller CA, Grinspoon SK, Stanley TL. Effects of Pitavastatin on Insulin Sensitivity and Liver Fat: A Randomized Clinical Trial. J Clin Endocrinol Metab. 2018 11 01; 103(11):4176-4186. PMID: 30239757.
    Citations:    Fields:    
  22. Osborne MT, Ishai A, Hammad B, Tung B, Wang Y, Baruch A, Fayad ZA, Giles JT, Lo J, Shin LM, Grinspoon SK, Koenen KC, Pitman RK, Tawakol A. Amygdalar activity predicts future incident diabetes independently of adiposity. Psychoneuroendocrinology. 2019 02; 100:32-40. PMID: 30273797.
    Citations:    Fields:    
  23. Srinivasa S, Fitch KV, Quadri N, Maehler P, O'Malley TK, Martinez-Salazar EL, Burdo TH, Feldpausch M, Torriani M, Adler GK, Grinspoon SK. Significant Association of Aldosterone and Liver Fat Among HIV-Infected Individuals With Metabolic Dysregulation. J Endocr Soc. 2018 Oct 01; 2(10):1147-1157. PMID: 30283827.
    Citations:    
  24. Toribio M, Fitch KV, Stone L, Zanni MV, Lo J, de Filippi C, Sponseller CA, Lee H, Grundberg I, Thompson MA, Aberg JA, Grinspoon SK. Assessing statin effects on cardiovascular pathways in HIV using a novel proteomics approach: Analysis of data from INTREPID, a randomized controlled trial. EBioMedicine. 2018 Sep; 35:58-66. PMID: 30174281.
    Citations:    Fields:    Translation:Humans
  25. Srinivasa S, Aulinas A, O'Malley T, Maehler P, Adler GK, Grinspoon SK, Lawson EA. Oxytocin response to controlled dietary sodium and angiotensin II among healthy individuals. Am J Physiol Endocrinol Metab. 2018 10 01; 315(4):E671-E675. PMID: 29944390.
    Citations:    Fields:    
  26. Looby SE, Psaros C, Raggio G, Rivard C, Smeaton L, Shifren J, Grinspoon S, Joffe H. Association between HIV status and psychological symptoms in perimenopausal women. Menopause. 2018 06; 25(6):648-656. PMID: 29381662.
    Citations:    Fields:    
  27. Srinivasa S, Fitch KV, Wong K, O'Malley TK, Maehler P, Branch KL, Looby SE, Burdo TH, Martinez-Salazar EL, Torriani M, Lyons SH, Weiss J, Feldpausch M, Stanley TL, Adler GK, Grinspoon SK. Randomized, Placebo-Controlled Trial to Evaluate Effects of Eplerenone on Metabolic and Inflammatory Indices in HIV. J Clin Endocrinol Metab. 2018 06 01; 103(6):2376-2384. PMID: 29659888.
    Citations: 1     Fields:    Translation:Humans
  28. Mosepele M, Molefe-Baikai OJ, Grinspoon SK, Triant VA. Benefits and Risks of Statin Therapy in the HIV-Infected Population. Curr Infect Dis Rep. 2018 May 26; 20(8):20. PMID: 29804227.
    Citations:    
  29. deFilippi C, Christenson R, Joyce J, Park EA, Wu A, Fitch KV, Looby SE, Lu MT, Hoffmann U, Grinspoon SK, Lo J. Brief Report: Statin Effects on Myocardial Fibrosis Markers in People Living With HIV. J Acquir Immune Defic Syndr. 2018 05 01; 78(1):105-110. PMID: 29419569.
    Citations: 1     Fields:    
  30. deFilippi C, Lo J, Christenson R, Grundberg I, Stone L, Zanni MV, Lee H, Grinspoon SK. Novel mediators of statin effects on plaque in HIV: a proteomics approach. AIDS. 2018 04 24; 32(7):867-876. PMID: 29369166.
    Citations:    Fields:    
  31. Fourman LT, Czerwonka N, Shaikh SD, Stanley TL, Burdo TH, Williams KC, Fitch KV, Lo J, Grinspoon SK. Insulin-like growth factor 1 inversely relates to monocyte/macrophage activation markers in HIV. AIDS. 2018 04 24; 32(7):927-932. PMID: 29424780.
    Citations: 1     Fields:    
  32. Murphy CA, Fitch KV, Feldpausch M, Maehler P, Wong K, Torriani M, Adler GK, Grinspoon SK, Srinivasa S. Excessive Adiposity and Metabolic Dysfunction Relate to Reduced Natriuretic Peptide During RAAS Activation in HIV. J Clin Endocrinol Metab. 2018 04 01; 103(4):1558-1565. PMID: 29408981.
    Citations:    Fields:    Translation:Humans
  33. Triant VA, Perez J, Regan S, Massaro JM, Meigs JB, Grinspoon SK, D'Agostino RB. Cardiovascular Risk Prediction Functions Underestimate Risk in HIV Infection. Circulation. 2018 05 22; 137(21):2203-2214. PMID: 29444987.
    Citations: 2     Fields:    
  34. Chow FC, Regan S, Zanni MV, Looby SE, Bushnell CD, Meigs JB, Grinspoon SK, Feske SK, Triant VA. Elevated ischemic stroke risk among women living with HIV infection. AIDS. 2018 Jan 02; 32(1):59-67. PMID: 28926405.
    Citations:    Fields:    Translation:Humans
  35. Grinspoon S. NOVEL MECHANISMS AND ANTI-INFLAMMATORY STRATEGIES TO REDUCE CARDIOVASCULAR RISK IN HUMAN IMMUNODEFICIENCY VIRUS. Trans Am Clin Climatol Assoc. 2018; 129:140-154. PMID: 30166708.
    Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
  36. Toribio M, Park MH, Zanni MV, Robbins GK, Burdo TH, Williams KC, Feldpausch MN, Stone L, Melbourne K, Grinspoon SK, Fitzgerald ML. HDL Cholesterol Efflux Capacity in Newly Diagnosed HIV and Effects of Antiretroviral Therapy. J Clin Endocrinol Metab. 2017 11 01; 102(11):4250-4259. PMID: 28945911.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  37. Triant VA, Grinspoon SK. Epidemiology of ischemic heart disease in HIV. Curr Opin HIV AIDS. 2017 Nov; 12(6):540-547. PMID: 28799997.
    Citations: 1     Fields: