Harvard Catalyst Profiles

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Steven Kyle Grinspoon, M.D.

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Mentoring
Available: 07/01/12, Expires: 07/01/20

Our lab studies body composition, and in particular central abdominal fat in the visceral depot. We investigate the clinical consequences in terms of inflammation, dyslipidemia, and insulin resistance, and have been focused on developing strategies to reduce the visceral fat using growth hormone releasing hormone and strategies to reduce inflammation using anti-TNF. The student will learn critical pathophysiology, clinical research skills and participate in data analysis with an eye toward contributing to the publication of a manuscript.

Physiologic investigation of the renin-angiotensin-aldosterone system and associated insulin resistance in HIV-infected patients
Summer, 06/17/13 - 08/09/13
The Effects of Metformin on Insulin Resistance in HIV-positive Patients with Upodystrophy
Part Time, 10/01/99 - 06/01/99
Growth Hormone Dynamics in HIV-Associated Fat Redistribution PASTEUR
Summer, 06/26/00 - 08/31/00

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01AI115711 (GRINSPOON, STEVEN K.) Dec 15, 2014 - Nov 30, 2017
    NIH/NIAID
    Tesamorelin Effects on Liver Fat and Histology in HIV: A Collaborative U01 Grant
    Role: Principal Investigator
  2. U01HL123336 (GRINSPOON, STEVEN K.) Aug 8, 2014 - Apr 30, 2020
    NIH/NHLBI
    REPRIEVE - CCC - Lead Application
    Role: Co-Principal Investigator
  3. R01HL095123 (GRINSPOON, STEVEN KYLE) Aug 15, 2009 - Jun 30, 2014
    NIH/NHLBI
    Inflammatory Mechanisms and Treatment Strategies for Atherosclerosis in HIV
    Role: Principal Investigator
  4. R01HL085268 (GRINSPOON, STEVEN KYLE) Sep 25, 2007 - Mar 31, 2012
    NIH/NHLBI
    Consequences and Treatment of Growth Hormone Deficiency in the Metabolic Syndrome
    Role: Principal Investigator
  5. T32HD052961 (GRINSPOON, STEVEN K) Sep 27, 2005 - Apr 30, 2017
    NIH/NICHD
    Training Program in Nutrition and Metabolism
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Srinivasa S, Fitch KV, Torriani M, Zanni MV, Defilippi C, Christenson R, Maehler P, Looby SE, Lo J, Grinspoon SK. Relationship of visceral and subcutaneous adipose depots to markers of arterial injury and inflammation among individuals with HIV. AIDS. 2019 Feb 01; 33(2):229-236. PMID: 30325779.
    Citations:    Fields:    
  2. Cheru LT, Fitch KV, Saylor CF, Lu M, Hoffmann U, Lo J, Grinspoon SK. Mild renal impairment is associated with calcified plaque parameters assessed by computed tomography angiography in people living with HIV. AIDS. 2019 Feb 01; 33(2):219-227. PMID: 30325774.
    Citations:    Fields:    
  3. deFilippi CR, Grinspoon SK. Myocardial Dysfunction With Contemporary Management of HIV: Prevalence, Pathophysiology, and Opportunities for Prevention. JACC Heart Fail. 2019 Feb; 7(2):109-111. PMID: 30704602.
    Citations:    Fields:    
  4. Weiss JJ, Sanchez L, Hubbard J, Lo J, Grinspoon SK, Fitch KV. Diet Quality Is Low and Differs by Sex in People with HIV. J Nutr. 2019 Jan 01; 149(1):78-87. PMID: 30624677.
    Citations:    Fields:    
  5. Mosepele M, Regan S, Massaro J, Meigs JB, Zanni MV, D'Agostino RB, Grinspoon SK, Triant VA. Impact of the American College of Cardiology/American Heart Association Cholesterol Guidelines on Statin Eligibility Among Human Immunodeficiency Virus-Infected Individuals. Open Forum Infect Dis. 2018 Dec; 5(12):ofy326. PMID: 30619912.
    Citations:    
  6. Braun LR, Feldpausch MN, Czerwonka N, Weiss J, Branch K, Lee H, Martinez-Salazar EL, Torriani M, Sponseller CA, Grinspoon SK, Stanley TL. Effects of Pitavastatin on Insulin Sensitivity and Liver Fat: A Randomized Clinical Trial. J Clin Endocrinol Metab. 2018 Nov 01; 103(11):4176-4186. PMID: 30239757.
    Citations:    Fields:    
  7. Ishai A, Osborne MT, Tung B, Wang Y, Hammad B, Patrich T, Oberfeld B, Fayad ZA, Giles JT, Lo J, Shin LM, Grinspoon SK, Koenen KC, Pitman RK, Tawakol A. Amygdalar Metabolic Activity Independently Associates with Progression of Visceral Adiposity. J Clin Endocrinol Metab. 2018 Oct 31. PMID: 30383236.
    Citations:    Fields:    
  8. Osborne MT, Ishai A, Hammad B, Tung B, Wang Y, Baruch A, Fayad ZA, Giles JT, Lo J, Shin LM, Grinspoon SK, Koenen KC, Pitman RK, Tawakol A. Amygdalar activity predicts future incident diabetes independently of adiposity. Psychoneuroendocrinology. 2019 Feb; 100:32-40. PMID: 30273797.
    Citations:    Fields:    
  9. Srinivasa S, Fitch KV, Quadri N, Maehler P, O'Malley TK, Martinez-Salazar EL, Burdo TH, Feldpausch M, Torriani M, Adler GK, Grinspoon SK. Significant Association of Aldosterone and Liver Fat Among HIV-Infected Individuals With Metabolic Dysregulation. J Endocr Soc. 2018 Oct 01; 2(10):1147-1157. PMID: 30283827.
    Citations:    
  10. Toribio M, Fitch KV, Stone L, Zanni MV, Lo J, de Filippi C, Sponseller CA, Lee H, Grundberg I, Thompson MA, Aberg JA, Grinspoon SK. Assessing statin effects on cardiovascular pathways in HIV using a novel proteomics approach: Analysis of data from INTREPID, a randomized controlled trial. EBioMedicine. 2018 Sep; 35:58-66. PMID: 30174281.
    Citations:    Fields:    Translation:Humans
  11. Srinivasa S, Aulinas A, O'Malley T, Maehler P, Adler GK, Grinspoon SK, Lawson EA. Oxytocin response to controlled dietary sodium and angiotensin II among healthy individuals. Am J Physiol Endocrinol Metab. 2018 Oct 01; 315(4):E671-E675. PMID: 29944390.
    Citations:    Fields:    
  12. Looby SE, Psaros C, Raggio G, Rivard C, Smeaton L, Shifren J, Grinspoon S, Joffe H. Association between HIV status and psychological symptoms in perimenopausal women. Menopause. 2018 Jun; 25(6):648-656. PMID: 29381662.
    Citations:    Fields:    
  13. Srinivasa S, Fitch KV, Wong K, O'Malley TK, Maehler P, Branch KL, Looby SE, Burdo TH, Martinez-Salazar EL, Torriani M, Lyons SH, Weiss J, Feldpausch M, Stanley TL, Adler GK, Grinspoon SK. Randomized, Placebo-Controlled Trial to Evaluate Effects of Eplerenone on Metabolic and Inflammatory Indices in HIV. J Clin Endocrinol Metab. 2018 06 01; 103(6):2376-2384. PMID: 29659888.
    Citations: 1     Fields:    Translation:Humans
  14. Mosepele M, Molefe-Baikai OJ, Grinspoon SK, Triant VA. Benefits and Risks of Statin Therapy in the HIV-Infected Population. Curr Infect Dis Rep. 2018 May 26; 20(8):20. PMID: 29804227.
    Citations:    
  15. deFilippi C, Christenson R, Joyce J, Park EA, Wu A, Fitch KV, Looby SE, Lu MT, Hoffmann U, Grinspoon SK, Lo J. Brief Report: Statin Effects on Myocardial Fibrosis Markers in People Living With HIV. J Acquir Immune Defic Syndr. 2018 May 01; 78(1):105-110. PMID: 29419569.
    Citations: 1     Fields:    
  16. deFilippi C, Lo J, Christenson R, Grundberg I, Stone L, Zanni MV, Lee H, Grinspoon SK. Novel mediators of statin effects on plaque in HIV: a proteomics approach. AIDS. 2018 Apr 24; 32(7):867-876. PMID: 29369166.
    Citations:    Fields:    
  17. Fourman LT, Czerwonka N, Shaikh SD, Stanley TL, Burdo TH, Williams KC, Fitch KV, Lo J, Grinspoon SK. Insulin-like growth factor 1 inversely relates to monocyte/macrophage activation markers in HIV. AIDS. 2018 Apr 24; 32(7):927-932. PMID: 29424780.
    Citations: 1     Fields:    
  18. Murphy CA, Fitch KV, Feldpausch M, Maehler P, Wong K, Torriani M, Adler GK, Grinspoon SK, Srinivasa S. Excessive Adiposity and Metabolic Dysfunction Relate to Reduced Natriuretic Peptide During RAAS Activation in HIV. J Clin Endocrinol Metab. 2018 04 01; 103(4):1558-1565. PMID: 29408981.
    Citations:    Fields:    Translation:Humans
  19. Triant VA, Perez J, Regan S, Massaro JM, Meigs JB, Grinspoon SK, D'Agostino RB. Cardiovascular Risk Prediction Functions Underestimate Risk in HIV Infection. Circulation. 2018 May 22; 137(21):2203-2214. PMID: 29444987.
    Citations: 2     Fields:    
  20. Chow FC, Regan S, Zanni MV, Looby SE, Bushnell CD, Meigs JB, Grinspoon SK, Feske SK, Triant VA. Elevated ischemic stroke risk among women living with HIV infection. AIDS. 2018 Jan 02; 32(1):59-67. PMID: 28926405.
    Citations:    Fields:    Translation:Humans
  21. Grinspoon S. NOVEL MECHANISMS AND ANTI-INFLAMMATORY STRATEGIES TO REDUCE CARDIOVASCULAR RISK IN HUMAN IMMUNODEFICIENCY VIRUS. Trans Am Clin Climatol Assoc. 2018; 129:140-154. PMID: 30166708.
    Citations:    Fields:    Translation:HumansAnimalsCellsPHPublic Health
  22. Toribio M, Park MH, Zanni MV, Robbins GK, Burdo TH, Williams KC, Feldpausch MN, Stone L, Melbourne K, Grinspoon SK, Fitzgerald ML. HDL Cholesterol Efflux Capacity in Newly Diagnosed HIV and Effects of Antiretroviral Therapy. J Clin Endocrinol Metab. 2017 11 01; 102(11):4250-4259. PMID: 28945911.
    Citations: 1     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  23. Triant VA, Grinspoon SK. Epidemiology of ischemic heart disease in HIV. Curr Opin HIV AIDS. 2017 Nov; 12(6):540-547. PMID: 28799997.
    Citations: 1     Fields:    Translation:Humans
  24. Fourman LT, Czerwonka N, Feldpausch MN, Weiss J, Mamputu JC, Falutz J, Morin J, Marsolais C, Stanley TL, Grinspoon SK. Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV. AIDS. 2017 10 23; 31(16):2253-2259. PMID: 28832410.
    Citations:    Fields:    Translation:Humans
  25. Fourman LT, Lu MT, Lee H, Fitch KV, Hallett TR, Park J, Czerwonka N, Weiss J, Stanley TL, Lo J, Grinspoon SK. Differential relationships of hepatic and epicardial fat to body composition in HIV. Physiol Rep. 2017 Oct; 5(19). PMID: 29038352.
    Citations:    Fields:    Translation:Humans
  26. Zanni MV, Stone LA, Toribio M, Rimmelin DE, Robinson J, Burdo TH, Williams K, Fitch KV, Lo J, Grinspoon SK. Proprotein Convertase Subtilisin/Kexin 9 Levels in Relation to Systemic Immune Activation and Subclinical Coronary Plaque in HIV. Open Forum Infect Dis. 2017; 4(4):ofx227. PMID: 29226174.
    Citations:    
  27. Braun LR, Feldpausch MN, Czerwonka N, Torriani M, Grinspoon SK, Stanley TL. Fibroblast growth factor 21 decreases after liver fat reduction via growth hormone augmentation. Growth Horm IGF Res. 2017 12; 37:1-6. PMID: 29031905.
    Citations: 1     Fields:    Translation:Humans
  28. Janjua SA, Staziaki PV, Szilveszter B, Takx RAP, Mayrhofer T, Hennessy O, Emami HA, Park J, Ivanov A, Hallett TR, Lu MT, Romero JM, Grinspoon SK, Hoffmann U, Zanni MV, Neilan TG. Presence, Characteristics, and Prognostic Associations of Carotid Plaque Among People Living With HIV. Circ Cardiovasc Imaging. 2017 10; 10(10). PMID: 29021257.
    Citations: 3     Fields:    Translation:Humans
  29. Teague HL, Ahlman MA, Alavi A, Wagner DD, Lichtman AH, Nahrendorf M, Swirski FK, Nestle F, Gelfand JM, Kaplan MJ, Grinspoon S, Ridker PM, Newby DE, Tawakol A, Fayad ZA, Mehta NN. Unraveling Vascular Inflammation: From Immunology to Imaging. J Am Coll Cardiol. 2017 Sep 12; 70(11):1403-1412. PMID: 28882238.
    Citations: 4     Fields:    Translation:Humans
  30. O'Malley TK, Burdo TH, Robinson JA, Fitch KV, Grinspoon SK, Srinivasa S. Acute hyperinsulinemia effects on systemic markers of immune activation in HIV. AIDS. 2017 07 31; 31(12):1771-1773. PMID: 28514281.
    Citations:    Fields:    Translation:Humans
  31. Grinspoon S, Hoffmann U. Cardiovascular Disease Imaging in HIV: Novel Phenotypes and New Targets for Risk Reduction. Circ Cardiovasc Imaging. 2017 Jul; 10(7). PMID: 28674087.
    Citations:    Fields:    
  32. Lake JE, Stanley TL, Apovian CM, Bhasin S, Brown TT, Capeau J, Currier JS, Dube MP, Falutz J, Grinspoon SK, Guaraldi G, Martinez E, McComsey GA, Sattler FR, Erlandson KM. Practical Review of Recognition and Management of Obesity and Lipohypertrophy in Human Immunodeficiency Virus Infection. Clin Infect Dis. 2017 May 15; 64(10):1422-1429. PMID: 28329372.
    Citations: 5     Fields:    Translation:Humans
  33. Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR. Corrigendum: Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature. 2017 05 10; 545(7653):252. PMID: 28492253.
    Citations: 2     Fields:    
  34. Hall LN, Sanchez LR, Hubbard J, Lee H, Looby SE, Srinivasa S, Zanni MV, Stanley TL, Lo J, Grinspoon SK, Fitch KV. Aspartame Intake Relates to Coronary Plaque Burden and Inflammatory Indices in Human Immunodeficiency Virus. Open Forum Infect Dis. 2017; 4(2):ofx083. PMID: 28695142.
    Citations:    
  35. Zanni MV, Toribio M, Wilks MQ, Lu MT, Burdo TH, Walker J, Autissier P, Foldyna B, Stone L, Martin A, Cope F, Abbruzzese B, Brady T, Hoffmann U, Williams KC, El-Fakhri G, Grinspoon SK. Application of a Novel CD206+ Macrophage-Specific Arterial Imaging Strategy in HIV-Infected Individuals. J Infect Dis. 2017 04 15; 215(8):1264-1269. PMID: 28204544.
    Citations: 5     Fields:    Translation:HumansCells
  36. Toribio M, Fitch KV, Sanchez L, Burdo TH, Williams KC, Sponseller CA, McCurdy Pate M, Aberg JA, Zanni MV, Grinspoon SK. Effects of pitavastatin and pravastatin on markers of immune activation and arterial inflammation in HIV. AIDS. 2017 03 27; 31(6):797-806. PMID: 28252528.
    Citations: 6     Fields:    Translation:Humans
  37. Zanni MV, Fitch K, Rivard C, Sanchez L, Douglas PS, Grinspoon S, Smeaton L, Currier JS, Looby SE. Follow YOUR Heart: development of an evidence-based campaign empowering older women with HIV to participate in a large-scale cardiovascular disease prevention trial. HIV Clin Trials. 2017 03; 18(2):83-91. PMID: 28277924.
    Citations: 1     Fields:    Translation:Humans
  38. Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, Gorden P, Kahn CR. Adipose-derived circulating miRNAs regulate gene expression in other tissues. Nature. 2017 02 23; 542(7642):450-455. PMID: 28199304.
    Citations: 64     Fields:    Translation:AnimalsCells
  39. Fitch KV, DeFilippi C, Christenson R, Srinivasa S, Lee H, Lo J, Lu MT, Wong K, Petrow E, Sanchez L, Looby SE, Hoffmann U, Zanni M, Grinspoon SK. Subclinical myocyte injury, fibrosis and strain in relationship to coronary plaque in asymptomatic HIV-infected individuals. AIDS. 2016 09 10; 30(14):2205-14. PMID: 27314177.
    Citations: 6     Fields:    Translation:HumansCells
  40. Srinivasa S, Burdo TH, Williams KC, Mitten EK, Wong K, Fitch KV, Stanley T, Adler GK, Grinspoon SK. Effects of Sodium Restriction on Activation of the Renin-Angiotensin-Aldosterone System and Immune Indices During HIV Infection. J Infect Dis. 2016 Nov 01; 214(9):1336-1340. PMID: 27549584.
    Citations: 2     Fields: &