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Katherine Phoenix Liao, M.D.

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Overview
Dr. Liao is an Associate Professor of Medicine and Assistant Professor of Bioinformatics at Harvard Medical School, Associate Physician in the Division of Rheumatology, Immunology, and Allergy, at Brigham and Women's Hospital (BWH), and a Staff Rheumatologist at the VA Boston Healthcare System. She serves as Director of the VERITY Bioinformatics Resource Core, and co-directs the Cardiovascular Rheumatology Clinic a collaboration between the BWH Divisions of Rheumatology and Cardiology. At Boston VA, she co-directs the Applied Bioinformatics Core for Clinical Research within the Massachusetts Veterans Epidemiology and Information Center which serves nationwide VA investigators.

Dr. Liao is a graduate of Williams College where she received her BA in Biology and Economics, SUNY Downstate Medical Center where she received her MD, and an MPH at the Harvard T.H. Chan School of Public Health. She completed internship and residency training in Internal Medicine at Massachusetts General Hospital, and rheumatology fellowship training at Brigham and Women's Hospital. Her research focuses on the clinical impact of inflammation on cardiovascular disease with a specific interest in rheumatoid arthritis. Her team also specializes in developing and applying bioinformatics approaches to utilize electronic health record data for clinical and translational studies.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P30AR072577 (SOLOMON, DANIEL HAL) Sep 20, 2017 - Aug 31, 2022
    NIH/NIAMS
    VERITY: Value and Evidence in Rheumatology using bioInformaTics, and advanced analYtics
    Role: PI, Bioinformatics Resource Core
  2. R01HL127118 (LIAO, KATHERINE PHOENIX) Apr 1, 2016 - Feb 28, 2021
    NIH/NHLBI
    Lipids, Inflammation, and Cardiovascular Risk in Rheumatoid Arthritis
    Role: Principal Investigator
  3. K08AR060257 (LIAO, KATHERINE PHOENIX) Jul 15, 2011 - Jun 30, 2016
    NIH/NIAMS
    Genetic Risk Factors for Coronary Artery Disease in Rheumatoid Arthritis
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ning W, Chan S, Beam A, Yu M, Geva A, Liao K, Mullen M, Mandl KD, Kohane I, Cai T, Yu S. f(1Feature Extraction for Phenotyping from Semantic and Knowledge Resources. J Biomed Inform. 2019 Feb 07; 103122. PMID: 30738949.
    Citations:    
  2. Hejblum BP, Weber GM, Liao KP, Palmer NP, Churchill S, Shadick NA, Szolovits P, Murphy SN, Kohane IS, Cai T. Probabilistic record linkage of de-identified research datasets with discrepancies using diagnosis codes. Sci Data. 2019 Jan 08; 6:180298. PMID: 30620344.
    Citations:    Fields:    
  3. Jorge A, Castro VM, Barnado A, Gainer V, Hong C, Cai T, Cai T, Carroll R, Denny JC, Crofford L, Costenbader KH, Liao KP, Karlson EW, Feldman CH. Identifying lupus patients in electronic health records: Development and validation of machine learning algorithms and application of rule-based algorithms. Semin Arthritis Rheum. 2019 Jan 04. PMID: 30665626.
    Citations:    Fields:    
  4. Chen SK, Liao KP, Liu J, Kim SC. Risk of Hospitalized Infection and Initiation of Abatacept versus TNF Inhibitors among Patients with Rheumatoid Arthritis: a Propensity Score-Matched Cohort Study. Arthritis Care Res (Hoboken). 2018 Dec 20. PMID: 30570833.
    Citations:    Fields:    
  5. Ljung L, Ueda P, Liao KP, Greenberg JD, Etzel CJ, Solomon DH, Askling J. Performance of the Expanded Cardiovascular Risk Prediction Score for Rheumatoid Arthritis in a geographically distant National Register-based cohort: an external validation. RMD Open. 2018; 4(2):e000771. PMID: 30622736.
    Citations:    
  6. Gronsbell J, Minnier J, Yu S, Liao K, Cai T. Automated Feature Selection of Predictors in Electronic Medical Records Data. Biometrics. 2018 Oct 24. PMID: 30353541.
    Citations:    Fields:    
  7. Imran TF, Posner D, Honerlaw J, Vassy JL, Song RJ, Ho YL, Kittner SJ, Liao KP, Cai T, O'Donnell CJ, Djousse L, Gagnon DR, Gaziano JM, Wilson PW, Cho K. A phenotyping algorithm to identify acute ischemic stroke accurately from a national biobank: the Million Veteran Program. Clin Epidemiol. 2018; 10:1509-1521. PMID: 30425582.
    Citations:    
  8. Sinnott JA, Cai F, Yu S, Hejblum BP, Hong C, Kohane IS, Liao KP. PheProb: probabilistic phenotyping using diagnosis codes to improve power for genetic association studies. J Am Med Inform Assoc. 2018 Oct 01; 25(10):1359-1365. PMID: 29788308.
    Citations:    Fields:    
  9. Hong C, Liao KP, Cai T. Semi-supervised validation of multiple surrogate outcomes with application to electronic medical records phenotyping. Biometrics. 2018 Sep 29. PMID: 30267536.
    Citations:    Fields:    
  10. Cai T, Lin TC, Bond A, Huang J, Kane-Wanger G, Cagan A, Murphy SN, Ananthakrishnan AN, Liao KP. The Association Between Arthralgia and Vedolizumab Using Natural Language Processing. Inflamm Bowel Dis. 2018 Sep 15; 24(10):2242-2246. PMID: 29846617.
    Citations:    Fields:    
  11. Cai T, Zhang Y, Ho YL, Link N, Sun J, Huang J, Cai TA, Damrauer S, Ahuja Y, Honerlaw J, Huang J, Costa L, Schubert P, Hong C, Gagnon D, Sun YV, Gaziano JM, Wilson P, Cho K, Tsao P, O'Donnell CJ, Liao KP. Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy: A Phenome-Wide Association Study. JAMA Cardiol. 2018 Sep 01; 3(9):849-857. PMID: 30090940.
    Citations:    Fields:    
  12. Yu Z, Yang N, Everett BM, Frits M, Iannaccone C, Coblyn J, Weinblatt M, Shadick N, Solomon DH, Liao KP. Impact of Changes in Inflammation on Estimated Ten-Year Cardiovascular Risk in Rheumatoid Arthritis. Arthritis Rheumatol. 2018 Sep; 70(9):1392-1398. PMID: 29676517.
    Citations:    Fields:    
  13. Yu Z, Kim SC, Vanni K, Huang J, Desai R, Murphy SN, Solomon DH, Liao KP. Association between inflammation and systolic blood pressure in RA compared to patients without RA. Arthritis Res Ther. 2018 06 01; 20(1):107. PMID: 29855349.
    Citations:    Fields:    
  14. Kang EH, Liao KP, Kim SC. Cardiovascular Safety of Biologics and JAK Inhibitors in Patients with Rheumatoid Arthritis. Curr Rheumatol Rep. 2018 May 30; 20(7):42. PMID: 29846814.
    Citations:    Fields:    
  15. Hejblum BP, Cui J, Lahey LJ, Cagan A, Sparks JA, Sokolove J, Cai T, Liao KP. Association Between Anti-Citrullinated Fibrinogen Antibodies and Coronary Artery Disease in Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2018 Jul; 70(7):1113-1117. PMID: 28992379.
    Citations:    Fields:    
  16. Tedeschi SK, Solomon DH, Liao KP. Pseudogout among Patients Fulfilling a Billing Code Algorithm for Calcium Pyrophosphate Deposition Disease. Rheumatol Int. 2018 Jun; 38(6):1083-1088. PMID: 29666904.
    Citations:    Fields:    Translation:Humans
  17. Plutzky J, Liao KP. Lipids in RA: Is Less Not Necessarily More? Curr Rheumatol Rep. 2018 02 21; 20(2):8. PMID: 29464513.
    Citations: 1     Fields:    
  18. Yu S, Ma Y, Gronsbell J, Cai T, Ananthakrishnan AN, Gainer VS, Churchill SE, Szolovits P, Murphy SN, Kohane IS, Liao KP, Cai T. Enabling phenotypic big data with PheNorm. J Am Med Inform Assoc. 2018 01 01; 25(1):54-60. PMID: 29126253.
    Citations: 2     Fields:    Translation:Humans
  19. Alemao E, Cawston H, Bourhis F, Al M, Rutten-van Molken M, Liao KP, Solomon DH. Comparison of cardiovascular risk algorithms in patients with vs without rheumatoid arthritis and the role of C-reactive protein in predicting cardiovascular outcomes in rheumatoid arthritis. Rheumatology (Oxford). 2017 05 01; 56(5):777-786. PMID: 28087832.
    Citations: 3     Fields:    Translation:Humans
  20. Liao KP, Sparks JA, Hejblum BP, Kuo IH, Cui J, Lahey LJ, Cagan A, Gainer VS, Liu W, Cai TT, Sokolove J, Cai T. Phenome-Wide Association Study of Autoantibodies to Citrullinated and Noncitrullinated Epitopes in Rheumatoid Arthritis. Arthritis Rheumatol. 2017 04; 69(4):742-749. PMID: 27792870.
    Citations: 5     Fields:    Translation:Humans
  21. Yu S, Chakrabortty A, Liao KP, Cai T, Ananthakrishnan AN, Gainer VS, Churchill SE, Szolovits P, Murphy SN, Kohane IS, Cai T. Surrogate-assisted feature extraction for high-throughput phenotyping. J Am Med Inform Assoc. 2017 Apr 01; 24(e1):e143-e149. PMID: 27632993.
    Citations: 1     Fields:    Translation:Humans
  22. Terao C, Kawaguchi T, Dieude P, Varga J, Kuwana M, Hudson M, Kawaguchi Y, Matucci-Cerinic M, Ohmura K, Riemekasten G, Kawasaki A, Airo P, Horita T, Oka A, Hachulla E, Yoshifuji H, Caramaschi P, Hunzelmann N, Baron M, Atsumi T, Hassoun P, Torii T, Takahashi M, Tabara Y, Shimizu M, Tochimoto A, Ayuzawa N, Yanagida H, Furukawa H, Tohma S, Hasegawa M, Fujimoto M, Ishikawa O, Yamamoto T, Goto D, Asano Y, Jinnin M, Endo H, Takahashi H, Takehara K, Sato S, Ihn H, Raychaudhuri S, Liao K, Gregersen P, Tsuchiya N, Riccieri V, Melchers I, Valentini G, Cauvet A, Martinez M, Mimori T, Matsuda F, Allanore Y. Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis. Ann Rheum Dis. 2017 Jun; 76(6):1150-1158. PMID: 28314753.
    Citations: 2     Fields:    Translation:Humans
  23. Bobb JF, Ho KK, Yeh RW, Harrington L, Zai A, Liao KP, Dominici F. Time-Course of Cause-Specific Hospital Admissions During Snowstorms: An Analysis of Electronic Medical Records From Major Hospitals in Boston, Massachusetts. Am J Epidemiol. 2017 02 15; 185(4):283-294. PMID: 28137774.
    Citations:    Fields:    Translation:Humans
  24. Liao KP. Through the looking glass of rheumatoid arthritis to study inflammation and high-density lipoprotein. Heart. 2017 05; 103(10):734-735. PMID: 28069636.
    Citations:    
  25. Yazdany J, Bansback N, Clowse M, Collier D, Law K, Liao KP, Michaud K, Morgan EM, Oates JC, Orozco C, Reimold A, Simard JF, Myslinski R, Kazi S. Rheumatology Informatics System for Effectiveness: A National Informatics-Enabled Registry for Quality Improvement. Arthritis Care Res (Hoboken). 2016 12; 68(12):1866-1873. PMID: 27696755.
    Citations: 4     Fields:    Translation:Humans
  26. An J, Alemao E, Reynolds K, Kawabata H, Solomon DH, Liao KP, Niu F, Cheetham TC. Cardiovascular Outcomes Associated with Lowering Low-density Lipoprotein Cholesterol in Rheumatoid Arthritis and Matched Nonrheumatoid Arthritis. J Rheumatol. 2016 11; 43(11):1989-1996. PMID: 27585690.
    Citations: 2     Fields:    Translation:Humans
  27. Liao KP. Cardiovascular disease in patients with rheumatoid arthritis. Trends Cardiovasc Med. 2017 02; 27(2):136-140. PMID: 27612551.
    Citations: 4     Fields:    Translation:Humans
  28. Sparks JA, Chang SC, Liao KP, Lu B, Fine AR, Solomon DH, Costenbader KH, Karlson EW. Rheumatoid Arthritis and Mortality Among Women During 36 Years of Prospective Follow-Up: Results From the Nurses' Health Study. Arthritis Care Res (Hoboken). 2016 06; 68(6):753-62. PMID: 26473946.
    Citations: 15     Fields:    Translation:Humans
  29. Desai RJ, Solomon DH, Schneeweiss S, Danaei G, Liao KP, Kim SC. Tumor Necrosis Factor-a Inhibitor Use and the Risk of Incident Hypertension in Patients with Rheumatoid Arthritis. Epidemiology. 2016 May; 27(3):414-22. PMID: 26808597.
    Citations: 1     Fields:    Translation:Humans
  30. An J, Cheetham TC, Reynolds K, Alemao E, Kawabata H, Liao KP, Solomon DH. Traditional Cardiovascular Disease Risk Factor Management in Rheumatoid Arthritis Compared to Matched Nonrheumatoid Arthritis in a US Managed Care Setting. Arthritis Care Res (Hoboken). 2016 05; 68(5):629-37. PMID: 26414069.
    Citations: 4     Fields:    Translation:Humans
  31. Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Shaw SY, Savova G, Churchill S, Karlson EW, Kohane I, Liao KP, Murphy SN. Comparative Effectiveness of Infliximab and Adalimumab in Crohn's Disease and Ulcerative Colitis. Inflamm Bowel Dis. 2016 Apr; 22(4):880-5. PMID: 26933751.
    Citations: 5     Fields:    Translation:Humans
  32. Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Shaw SY, Churchill S, Karlson EW, Murphy SN, Liao KP, Kohane I. Statin Use Is Associated With Reduced Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2016 07; 14(7):973-9. PMID: 26905907.
    Citations: 5     Fields:    Translation:Humans
  33. Agniel D, Liao KP, Cai T. Estimation and testing for multiple regulation of multivariate mixed outcomes. Biometrics. 2016 12; 72(4):1194-1205. PMID: 26910481.
    Citations: 1     Fields:    Translation:Humans
  34. Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Shaw SY, Savova G, Churchill S, Karlson EW, Murphy SN, Liao KP, Kohane I. Identification of Nonresponse to Treatment Using Narrative Data in an Electronic Health Record Inflammatory Bowel Disease Cohort. Inflamm Bowel Dis. 2016 Jan; 22(1):151-8. PMID: 26332313.
    Citations: 4     Fields:    Translation:Humans
  35. Alemao E, Cawston H, Bourhis F, Al M, Rutten-van Mölken MP, Liao KP, Solomon DH. Cardiovascular risk factor management in patients with RA compared to matched non-RA patients. Rheumatology (Oxford). 2016 May; 55(5):809-16. PMID: 26705329; PMCID: PMC4830910.
    Citations: 4     Fields:    Translation:Humans
  36. Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP, Xavier RJ. Common Genetic Variants Influence Circulating Vitamin D Levels in Inflammatory Bowel Diseases. Inflamm Bowel Dis. 2015 Nov; 21(11):2507-14. PMID: 26241000.
    Citations: 6     Fields:    Translation:Humans
  37. Jacobson TA, Maki KC, Orringer CE, Jones PH, Kris-Etherton P, Sikand G, La Forge R, Daniels SR, Wilson DP, Morris PB, Wild RA, Grundy SM, Daviglus M, Ferdinand KC, Vijayaraghavan K, Deedwania PC, Aberg JA, Liao KP, McKenney JM, Ross JL, Braun LT, Ito MK, Bays HE, Brown WV, Underberg JA. National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2. J Clin Lipidol. 2015 Nov-Dec; 9(6 Suppl):S1-122.e1. PMID: 26699442.
    Citations: 29     Fields:    Translation:Humans
  38. Liao KP, Ananthakrishnan AN, Kumar V, Xia Z, Cagan A, Gainer VS, Goryachev S, Chen P, Savova GK, Agniel D, Churchill S, Lee J, Murphy SN, Plenge RM, Szolovits P, Kohane I, Shaw SY, Karlson EW, Cai T. Methods to Develop an Electronic Medical Record Phenotype Algorithm to Compare the Risk of Coronary Artery Disease across 3 Chronic Disease Cohorts. PLoS One. 2015; 10(8):e0136651. PMID: 26301417.
    Citations: 10     Fields:    Translation:Humans
  39. Liao KP, Liu J, Lu B, Solomon DH, Kim SC. Association between lipid levels and major adverse cardiovascular events in rheumatoid arthritis compared to non-rheumatoid arthritis patients. Arthritis Rheumatol. 2015 May; 67(8):2004-10. PMID: 25917955; PMCID: PMC4418211.
    Citations: 7     Fields:    Translation:Humans
  40. Yu S, Liao KP, Shaw SY, Gainer VS, Churchill SE, Szolovits P, Murphy SN, Kohane IS, Cai T. Toward high-throughput phenotyping: unbiased automated feature extraction and selection from knowledge sources. J Am Med Inform Assoc. 2015 Sep; 22(5):993-1000. PMID: 25929596; PMCID: PMC4986664.
    Citations: 27     Fields:    Translation:Humans
  41. Liao KP, Cai T, Savova GK, Murphy SN, Karlson EW, Ananthakrishnan AN, Gainer VS, Shaw SY, Xia Z, Szolovits P, Churchill S, Kohane I. Development of phenotype algorithms using electronic medical records and incorporating natural language processing. BMJ. 2015 Apr 24; 350:h1885. PMID: 25911572; PMCID: PMC4707569.
    Citations: 23     Fields:    Translation:Humans
  42. Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP. Diabetes and the risk of infections with immunomodulator therapy in inflammatory bowel diseases. Aliment Pharmacol Ther. 2015 Jun; 41(11):1141-8. PMID: 25864945; PMCID: PMC4420684.
    Citations: 5     Fields:    Translation:Humans
  43. Diogo D, Bastarache L, Liao KP, Graham RR, Fulton RS, Greenberg JD, Eyre S, Bowes J, Cui J, Lee A, Pappas DA, Kremer JM, Barton A, Coenen MJ, Franke B, Kiemeney LA, Mariette X, Richard-Miceli C, Canhão H, Fonseca JE, de Vries N, Tak PP, Crusius JB, Nurmohamed MT, Kurreeman F, Mikuls TR, Okada Y, Stahl EA, Larson DE, Deluca TL, O'Laughlin M, Fronick CC, Fulton LL, Kosoy R, Ransom M, Bhangale TR, Ortmann W, Cagan A, Gainer V, Karlson EW, Kohane I, Murphy SN, Martin J, Zhernakova A, Klareskog L, Padyukov L, Worthington J, Mardis ER, Seldin MF, Gregersen PK, Behrens T, Raychaudhuri S, Denny JC, Plenge RM. TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits. PLoS One. 2015; 10(4):e0122271. PMID: 25849893; PMCID: PMC4388675.
    Citations: 19     Fields:    Translation:Humans
  44. Desai RJ, Eddings W, Liao KP, Solomon DH, Kim SC. Disease-modifying antirheumatic drug use and the risk of incident hyperlipidemia in patients with early rheumatoid arthritis: a retrospective cohort study. Arthritis Care Res (Hoboken). 2015 Apr; 67(4):457-66. PMID: 25302481; PMCID: PMC4751079.
    Citations: 5     Fields:    Translation:Humans
  45. Liao KP, Solomon DH. Editorial: inflammation, disease-modifying antirheumatic drugs, lipids, and cardiovascular risk in rheumatoid arthritis. Arthritis Rheumatol. 2015 Feb; 67(2):327-9. PMID: 25331004.
    Citations: 1     Fields:    Translation:Humans
  46. Liao KP, Playford MP, Frits M, Coblyn JS, Iannaccone C, Weinblatt ME, Shadick NS, Mehta NN. The association between reduction in inflammation and changes in lipoprotein levels and HDL cholesterol efflux capacity in rheumatoid arthritis. J Am Heart Assoc. 2015 Jan 30; 4(2). PMID: 25637346; PMCID: PMC4345878.
    Citations: 18     Fields:    Translation:Humans
  47. Brown LE, Frits ML, Iannaccone CK, Weinblatt ME, Shadick NA, Liao KP. Clinical characteristics of RA patients with secondary SS and association with joint damage. Rheumatology (Oxford). 2015 May; 54(5):816-20. PMID: 25313147; PMCID: PMC4416083.
    Citations: 1     Fields:    Translation:Humans
  48. Ananthakrishnan AN, Cheng A, Cagan A, Cai T, Gainer VS, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP. Mode of childbirth and long-term outcomes in women with inflammatory bowel diseases. Dig Dis Sci. 2015 Feb; 60(2):471-7. PMID: 25213079; PMCID: PMC4304947.
    Citations: 2     Fields:    Translation:Humans
  49. Shen Y, Liao KP, Cai T. Sparse kernel machine regression for ordinal outcomes. Biometrics. 2015 Mar; 71(1):63-70. PMID: 25196727; PMCID: PMC4609171.
    Citations: 1     Fields:    Translation:Humans
  50. Sinnott JA, Dai W, Liao KP, Shaw SY, Ananthakrishnan AN, Gainer VS, Karlson EW, Churchill S, Szolovits P, Murphy S, Kohane I, Plenge R, Cai T. Improving the power of genetic association tests with imperfect phenotype derived from electronic medical records. Hum Genet. 2014 Nov; 133(11):1369-82. PMID: 25062868; PMCID: PMC4185241.
    Citations: 7     Fields:    Translation:Humans
  51. Ananthakrishnan AN, Cagan A, Cai T, Gainer VS, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP. Colonoscopy is associated with a reduced risk for colon cancer and mortality in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol. 2015 Feb; 13(2):322-329.e1. PMID: 25041865.
    Citations: 15     Fields:    Translation:Humans
  52. Liao KP, Solomon DH. Mechanistic insights into the link between inflammation and cardiovascular disease: rheumatoid arthritis as a human model of inflammation. Circ Cardiovasc Imaging. 2014 Jul; 7(4):575-7. PMID: 25027451.
    Citations: 1     Fields:    Translation:Humans
  53. Ananthakrishnan AN, Cagan A, Gainer VS, Cheng SC, Cai T, Szolovits P, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP. Higher plasma vitamin D is associated with reduced risk of Clostridium difficile infection in patients with inflammatory bowel diseases. Aliment Pharmacol Ther. 2014 May; 39(10):1136-42. PMID: 24641590.
    Citations: 21     Fields:    Translation:HumansCells
  54. Ananthakrishnan AN, Cagan A, Gainer VS, Cheng SC, Cai T, Scoville E, Konijeti GG, Szolovits P, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP. Thromboprophylaxis is associated with reduced post-hospitalization venous thromboembolic events in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol. 2014 Nov; 12(11):1905-10. PMID: 24632349.
    Citations: 6     Fields:    Translation:Humans
  55. Ananthakrishnan AN, Cagan A, Gainer VS, Cheng SC, Cai T, Szolovits P, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP. Mortality and extraintestinal cancers in patients with primary sclerosing cholangitis and inflammatory bowel disease. J Crohns Colitis. 2014 Sep; 8(9):956-63. PMID: 24559536; PMCID: PMC4136996.
    Citations: 11     Fields:    Translation:Humans
  56. Kim K, Bang SY, Lee HS, Cho SK, Choi CB, Sung YK, Kim TH, Jun JB, Yoo DH, Kang YM, Kim SK, Suh CH, Shim SC, Lee SS, Lee J, Chung WT, Choe JY, Shin HD, Lee JY, Han BG, Nath SK, Eyre S, Bowes J, Pappas DA, Kremer JM, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Ärlestig L, Okada Y, Diogo D, Liao KP, Karlson EW, Raychaudhuri S, Rantapää-Dahlqvist S, Martin J, Klareskog L, Padyukov L, Gregersen PK, Worthington J, Greenberg JD, Plenge RM, Bae SC. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. Ann Rheum Dis. 2015 Mar; 74(3):e13. PMID: 24532676; PMCID: PMC4467986.
    Citations: 26     Fields:    Translation:Humans
  57. Ananthakrishnan AN, Cheng SC, Cai T, Cagan A, Gainer VS, Szolovits P, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP. Serum inflammatory markers and risk of colorectal cancer in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol. 2014 Aug; 12(8):1342-8.e1. PMID: 24407106.
    Citations: 11     Fields:    Translation:Humans
  58. Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, Jiang L, Yin J, Ye L, Su DF, Yang J, Xie G, Keystone E, Westra HJ, Esko T, Metspalu A, Zhou X, Gupta N, Mirel D, Stahl EA, Diogo D, Cui J, Liao K, Guo MH, Myouzen K, Kawaguchi T, Coenen MJ, van Riel PL, van de Laar MA, Guchelaar HJ, Huizinga TW, Dieudé P, Mariette X, Bridges SL, Zhernakova A, Toes RE, Tak PP, Miceli-Richard C, Bang SY, Lee HS, Martin J, Gonzalez-Gay MA, Rodriguez-Rodriguez L, Rantapää-Dahlqvist S, Arlestig L, Choi HK, Kamatani Y, Galan P, Lathrop M, Eyre S, Bowes J, Barton A, de Vries N, Moreland LW, Criswell LA, Karlson EW, Taniguchi A, Yamada R, Kubo M, Liu JS, Bae SC, Worthington J, Padyukov L, Klareskog L, Gregersen PK, Raychaudhuri S, Stranger BE, De Jager PL, Franke L, Visscher PM, Brown MA, Yamanaka H, Mimori T, Takahashi A, Xu H, Behrens TW, Siminovitch KA, Momohara S, Matsuda F, Yamamoto K, Plenge RM. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature. 2014 Feb 20; 506(7488):376-81. PMID: 24390342; PMCID: PMC3944098.
    Citations: 382     Fields:    Translation:HumansAnimals
  59. Liao KP, Cai T, Gainer VS, Cagan A, Murphy SN, Liu C, Churchill S, Shaw SY, Kohane I, Solomon DH, Plenge RM, Karlson EW. Lipid and lipoprotein levels and trend in rheumatoid arthritis compared to the general population. Arthritis Care Res (Hoboken). 2013 Dec; 65(12):2046-50. PMID: 23925980; PMCID: PMC4060244.
    Citations: 13     Fields:    Translation:Humans
  60. Xia Z, Secor E, Chibnik LB, Bove RM, Cheng S, Chitnis T, Cagan A, Gainer VS, Chen PJ, Liao KP, Shaw SY, Ananthakrishnan AN, Szolovits P, Weiner HL, Karlson EW, Murphy SN, Savova GK, Cai T, Churchill SE, Plenge RM, Kohane IS, De Jager PL. Modeling disease severity in multiple sclerosis using electronic health records. PLoS One. 2013; 8(11):e78927. PMID: 24244385; PMCID: PMC3823928.
    Citations: 19     Fields:    Translation:HumansCTClinical Trials
  61. Ananthakrishnan AN, Cheng SC, Cai T, Cagan A, Gainer VS, Szolovits P, Shaw SY, Churchill S, Karlson EW, Murphy SN, Kohane I, Liao KP. Association between reduced plasma 25-hydroxy vitamin D and increased risk of cancer in patients with inflammatory bowel diseases. Clin Gastroenterol Hepatol. 2014 May; 12(5):821-7. PMID: 24161349.
    Citations: 26     Fields:    Translation:Humans
  62. Crowson CS, Liao KP, Davis JM, Solomon DH, Matteson EL, Knutson KL, Hlatky MA, Gabriel SE. Rheumatoid arthritis and cardiovascular disease. Am Heart J. 2013 Oct; 166(4):622-628.e1. PMID: 24093840; PMCID: PMC3890244.
    Citations: 34     Fields:    Translation:Humans
  63. Ananthakrishnan AN, Cagan A, Gainer VS, Cai T, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw SY, Churchill S, Karlson EW, Kohane I, Plenge RM, Murphy SN, Liao KP. Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease. Inflamm Bowel Dis. 2013 Aug; 19(9):1921-7. PMID: 23751398.
    Citations: 50     Fields:    Translation:Humans
  64. Karlson EW, Ding B, Keenan BT, Liao K, Costenbader KH, Klareskog L, Alfredsson L, Chibnik LB. Association of environmental and genetic factors and gene-environment interactions with risk of developing rheumatoid arthritis. Arthritis Care Res (Hoboken). 2013 Jul; 65(7):1147-56. PMID: 23495093; PMCID: PMC3740546.
    Citations: 19     Fields:    Translation:Humans
  65. Ananthakrishnan AN, Cai T, Savova G, Cheng SC, Chen P, Perez RG, Gainer VS, Murphy SN, Szolovits P, Xia Z, Shaw S, Churchill S, Karlson EW, Kohane I, Plenge RM, Liao KP. Improving case definition of Crohn's disease and ulcerative colitis in electronic medical records using natural language processing: a novel informatics approach. Inflamm Bowel Dis. 2013 Jun; 19(7):1411-20. PMID: 23567779.
    Citations: 40     Fields:    Translation:Humans
  66. Liao KP, Diogo D, Cui J, Cai T, Okada Y, Gainer VS, Murphy SN, Gupta N, Mirel D, Ananthakrishnan AN, Szolovits P, Shaw SY, Raychaudhuri S, Churchill S, Kohane I, Karlson EW, Plenge RM. Association between low density lipoprotein and rheumatoid arthritis genetic factors with low density lipoprotein levels in rheumatoid arthritis and non-rheumatoid arthritis controls. Ann Rheum Dis. 2014 Jun; 73(6):1170-5. PMID: 23716066; PMCID: PMC3815491.
    Citations: 8     Fields:    Translation:Humans
  67. Liao KP, Kurreeman F, Li G, Duclos G, Murphy S, Guzman R, Cai T, Gupta N, Gainer V, Schur P, Cui J, Denny JC, Szolovits P, Churchill S, Kohane I, Karlson EW, Plenge RM. Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non-rheumatoid arthritis controls. Arthritis Rheum. 2013 Mar; 65(3):571-81. PMID: 23233247; PMCID: PMC3582761.
    Citations: 31     Fields:    Translation:Humans
  68. Henderson LA, Loring SH, Gill RR, Liao KP, Ishizawar R, Kim S, Perlmutter-Goldenson R, Rothman D, Son MB, Stoll ML, Zemel LS, Sandborg C, Dellaripa PF, Nigrovic PA. Shrinking lung syndrome as a manifestation of pleuritis: a new model based on pulmonary physiological studies. J Rheumatol. 2013 Mar; 40(3):273-81. PMID: 23378468; PMCID: PMC4112073.
    Citations: 5     Fields:    Translation:Humans
  69. Ananthakrishnan AN, Gainer VS, Cai T, Perez RG, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw S, Churchill S, Karlson EW, Kohane I, Perlis RH, Plenge RM, Murphy SN, Liao KP. Similar risk of depression and anxiety following surgery or hospitalization for Crohn's disease and ulcerative colitis. Am J Gastroenterol. 2013 Apr; 108(4):594-601. PMID: 23337479; PMCID: PMC3627544.
    Citations: 16     Fields:    Translation:Humans
  70. Ananthakrishnan AN, Gainer VS, Perez RG, Cai T, Cheng SC, Savova G, Chen P, Szolovits P, Xia Z, De Jager PL, Shaw SY, Churchill S, Karlson EW, Kohane I, Perlis RH, Plenge RM, Murphy SN, Liao KP. Psychiatric co-morbidity is associated with increased risk of surgery in Crohn's disease. Aliment Pharmacol Ther. 2013 Feb; 37(4):445-54. PMID: 23289600; PMCID: PMC3552092.
    Citations: 24     Fields:    Translation:Humans
  71. Diogo D, Kurreeman F, Stahl EA, Liao KP, Gupta N, Greenberg JD, Rivas MA, Hickey B, Flannick J, Thomson B, Guiducci C, Ripke S, Adzhubey I, Barton A, Kremer JM, Alfredsson L, Sunyaev S, Martin J, Zhernakova A, Bowes J, Eyre S, Siminovitch KA, Gregersen PK, Worthington J, Klareskog L, Padyukov L, Raychaudhuri S, Plenge RM. Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis. Am J Hum Genet. 2013 Jan 10; 92(1):15-27. PMID: 23261300; PMCID: PMC3542467.
    Citations: 36     Fields:    Translation:Humans
  72. Liao KP, Solomon DH. Traditional cardiovascular risk factors, inflammation and cardiovascular risk in rheumatoid arthritis. Rheumatology (Oxford). 2013 Jan; 52(1):45-52. PMID: 22986289; PMCID: PMC3521444.
    Citations: 36     Fields:    Translation:Humans
  73. Carroll RJ, Thompson WK, Eyler AE, Mandelin AM, Cai T, Zink RM, Pacheco JA, Boomershine CS, Lasko TA, Xu H, Karlson EW, Perez RG, Gainer VS, Murphy SN, Ruderman EM, Pope RM, Plenge RM, Kho AN, Liao KP, Denny JC. Portability of an algorithm to identify rheumatoid arthritis in electronic health records. J Am Med Inform Assoc. 2012 Jun; 19(e1):e162-9. PMID: 22374935; PMCID: PMC3392871.
    Citations: 81     Fields:    Translation:Humans
  74. Kurreeman FA, Stahl EA, Okada Y, Liao K, Diogo D, Raychaudhuri S, Freudenberg J, Kochi Y, Patsopoulos NA, Gupta N, Sandor C, Bang SY, Lee HS, Padyukov L, Suzuki A, Siminovitch K, Worthington J, Gregersen PK, Hughes LB, Reynolds RJ, Bridges SL, Bae SC, Yamamoto K, Plenge RM. Use of a multiethnic approach to identify rheumatoid- arthritis-susceptibility loci, 1p36 and 17q12. Am J Hum Genet. 2012 Mar 09; 90(3):524-32. PMID: 22365150; PMCID: PMC3309197.
    Citations: 27     Fields:    Translation:HumansCells
  75. Chibnik LB, Keenan BT, Cui J, Liao KP, Costenbader KH, Plenge RM, Karlson EW. Genetic risk score predicting risk of rheumatoid arthritis phenotypes and age of symptom onset. PLoS One. 2011; 6(9):e24380. PMID: 21931699; PMCID: PMC3171415.
    Citations: 18     Fields:    Translation:Humans
  76. Liao KP, Bykerk V. All that glitters is not gold--standardizing diagnosis in rheumatoid arthritis studies. J Rheumatol. 2011 Jul; 38(7):1223-4. PMID: 21724709.
    Citations:    Fields:    Translation:Humans
  77. Liao KP, Weinblatt ME, Solomon DH. The end of rheumatoid factor as we know it? Arthritis Rheum. 2011 May; 63(5):1170-2. PMID: 21538308.
    Citations:    Fields:    Translation:Humans
  78. Liao KP, Weinblatt ME, Cui J, Iannaccone C, Chibnik LB, Lu B, Coblyn JS, Shadick NA, Solomon DH. Clinical predictors of erosion-free status in rheumatoid arthritis: a prospective cohort study. Rheumatology (Oxford). 2011 Aug; 50(8):1473-9. PMID: 21447567; PMCID: PMC3133482.
    Citations: 7     Fields:    Translation:Humans
  79. Kurreeman F, Liao K, Chibnik L, Hickey B, Stahl E, Gainer V, Li G, Bry L, Mahan S, Ardlie K, Thomson B, Szolovits P, Churchill S, Murphy SN, Cai T, Raychaudhuri S, Kohane I, Karlson E, Plenge RM. Genetic basis of autoantibody positive and negative rheumatoid arthritis risk in a multi-ethnic cohort derived from electronic health records. Am J Hum Genet. 2011 Jan 07; 88(1):57-69. PMID: 21211616; PMCID: PMC3014362.
    Citations: 48     Fields:    Translation:Humans
  80. Neogi T, Aletaha D, Silman AJ, Naden RL, Felson DT, Aggarwal R, Bingham CO, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Khanna D, Kvien TK, Laing T, Liao K, Mease P, Ménard HA, Moreland LW, Nair R, Pincus T, Ringold S, Smolen JS, Stanislawska-Biernat E, Symmons D, Tak PP, Upchurch KS, Vencovský J, Wolfe F, Hawker G. The 2010 American College of Rheumatology/European League Against Rheumatism classification criteria for rheumatoid arthritis: Phase 2 methodological report. Arthritis Rheum. 2010 Sep; 62(9):2582-91. PMID: 20872596; PMCID: PMC3077961.
    Citations: 57     Fields:    Translation:Humans
  81. Liao KP, Cai T, Gainer V, Goryachev S, Zeng-treitler Q, Raychaudhuri S, Szolovits P, Churchill S, Murphy S, Kohane I, Karlson EW, Plenge RM. Electronic medical records for discovery research in rheumatoid arthritis. Arthritis Care Res (Hoboken). 2010 Aug; 62(8):1120-7. PMID: 20235204; PMCID: PMC3121049.
    Citations: 99     Fields:    Translation:Humans
  82. Liao KP, Costenbader KH. Getting them even earlier: Identifying individuals before clinical presentation with rheumatoid arthritis. Arthritis Rheum. 2009 Dec 15; 61(12):1620-2. PMID: 19950327; PMCID: PMC2838473.
    Citations:    Fields:    Translation:HumansPHPublic Health
  83. Aggarwal R, Liao K, Nair R, Ringold S, Costenbader KH. Anti-citrullinated peptide antibody assays and their role in the diagnosis of rheumatoid arthritis. Arthritis Rheum. 2009 Nov 15; 61(11):1472-83. PMID: 19877103; PMCID: PMC2859449.
    Citations: 34     Fields:    Translation:Humans
  84. Liao KP, Alfredsson L, Karlson EW. Environmental influences on risk for rheumatoid arthritis. Curr Opin Rheumatol. 2009 May; 21(3):279-83. PMID: 19318947; PMCID: PMC2898190.
    Citations: 33     Fields:    Translation:HumansPHPublic Health
  85. Liao KP, Gunnarsson M, Källberg H, Ding B, Plenge RM, Padyukov L, Karlson EW, Klareskog L, Askling J, Alfredsson L. Specific association of type 1 diabetes mellitus with anti-cyclic citrullinated peptide-positive rheumatoid arthritis. Arthritis Rheum. 2009 Mar; 60(3):653-60. PMID: 19248096; PMCID: PMC2768389.
    Citations: 13     Fields:    Translation:Humans
  86. Katherine P. Liao and Elizabeth W. Karlson. Rheumatoid Arthritis: Classification and Epidemiology. Rheumatology. 2009; in press.
  87. Liao KP, Gaut J, Huang AJ, Cohen G. A 20-year-old man with right leg pain following orofacial surgery. Arthritis Rheum. 2008 Oct 15; 59(10):1527-32. PMID: 18821652.
    Citations:    Fields:    Translation:Humans
  88. Liao KP, Batra KL, Chibnik L, Schur PH, Costenbader KH. Anti-cyclic citrullinated peptide revised criteria for the classification of rheumatoid arthritis. Ann Rheum Dis. 2008 Nov; 67(11):1557-61. PMID: 18234714; PMCID: PMC2964864.
    Citations: 18     Fields:    Translation:Humans
  89. Katherine P. Liao, Robert Friday, Margaret Seton. Rheumatology. Pocket Medicine: The Massachusetts General Hospital Handbook of Internal Medicine. Marc S. Sabatine, editor. 2007.
  90. Kovarova M, Wassif CA, Odom S, Liao K, Porter FD, Rivera J. Cholesterol deficiency in a mouse model of Smith-Lemli-Opitz syndrome reveals increased mast cell responsiveness. J Exp Med. 2006 May 15; 203(5):1161-71. PMID: 16618793; PMCID: PMC2121200.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  91. Smith-Norowitz T, Norowitz K, Bluth M, Chice S, Joks R, Liao K, Nowakowski M, and H Durkin. CD8+CD60+ TCR alpha/beta+ CD45RO+ T cells and CD4+ T cells are required for induction of human ragweed specific memory IgE responses. Journal of Allergy and Clinical Immunology. 2005; 115(2 (Supplement)):S257.
  92. Katherine P. Liao. Genetic structuring in populations of the arctic disjunct, Sagina nodosa (Caryophyllaceae), in Michigan and Maine. 1999.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.