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Philip Stashenko, Ph.D., D.M.D.

Title
Institution
Department
Address
Profile Picture

Biography
1965 - 1969
University Scholar
1968
Phi Beta Kappa
1969
cum laude
1972 - 1976
Research Fellowship
1976 - 1977
Research Fellowship
1977 - 1978
Research Fellowship
1995
Distinguished Faculty Award
1995
Honorary Dental Society
1996
Omicron Kappa Upsilon
2000
IADR Pulp Biology Award Outstanding Research in Field
2004
Mentor for Hesham Youssef, AAE Oral Research Presentation (first Student category)
2004
Mentor for Ulrike Spaete, IADR Hatton Awardee (first posdoctoral category)
2006
Identified as top 5% of NIH extramural grant recipients over the past 25 years

Mentoring
Arg-gingipains as Virulence Factors in Periodontal Disease
Summer, 06/18/01 - 08/17/01
Gene Research
Summer, 07/01/03 - 08/31/03
Expression of IL-1 Isoforms as a diagnostic facator in periodontal lesions
Summer, 05/31/07 - 08/31/07
P. Gingivalis Gingipains as Virullence Factors in Periodontal Disease
Part Time/Continuation, 09/01/01 - 05/31/02
Effect of C-myc Inhibition on Osteoclastogenesis
Part Time/Continuation, 09/01/00 - 06/01/01
Expression and Function of Stra14 in Osteoclastogenesis
Part Time/Continuation, 09/01/01 - 12/31/01
Functional Analysis of Novel IL-1 Isoforms in Periapical Pathogenesis
Full Time/Year Long, 09/01/07 - 08/31/08
Expression and Function of Stra 14 During Osteoclastogenesis
Spanish, 06/18/01 - 08/24/01
Role and Relevance of Human EST 435890 in Osteoclast Differentiation
Summer, 06/19/00 - 08/11/00

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21DE028063 (STASHENKO, PHILIP) Jul 10, 2019 - Jun 30, 2021
    NIH/NIDCR
    Role of the Oral Microbiome in Oral Squamous Cell Carcinoma Progression
    Role: Principal Investigator
  2. C06RR028742 (STASHENKO, PHILIP) Feb 25, 2010 - Feb 24, 2013
    NIH/NCRR
    Forsyth Expansion for the Center for Discovery at the Host-Biofilm Interface
    Role: Principal Investigator
  3. K12DE014528 (STASHENKO, PHILIP) Aug 15, 2002 - Jun 30, 2008
    NIH/NIDCR
    Harvard-SDM/Forsyth Scholar/Faculty Development Program
    Role: Principal Investigator
  4. R01DE013747 (STASHENKO, PHILIP) Apr 15, 2001 - Jan 31, 2006
    NIH/NIDCR
    INNATE IMMUNITY AND PERIODONTAL DISEASE IN MICE
    Role: Principal Investigator
  5. C06RR011244 (STASHENKO, PHILIP) Apr 15, 1996 - Apr 14, 1999
    NIH/NCRR
    EXTRAMURAL RESEARCH FACILITIES CONSTRUCTION
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sasaki H, Furusho H, Rider DB, Dobeck JM, Kuo WP, Fujimura A, Yoganathan S, Hirai K, Xu S, Sasaki K, Stashenko P. Endodontic Infection-induced Inflammation Resembling Osteomyelitis of the Jaws in Toll-like Receptor 2/Interleukin 10 Double-knockout Mice. J Endod. 2019 Feb; 45(2):181-188. PMID: 30711175.
    Citations:    
  2. Yost S, Stashenko P, Choi Y, Kukuruzinska M, Genco CA, Salama A, Weinberg EO, Kramer CD, Frias-Lopez J. Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses. Int J Oral Sci. 2018 11 12; 10(4):32. PMID: 30420594.
    Citations:    Fields:    
  3. Hirai K, Furusho H, Kawashima N, Xu S, de Beer MC, Battaglino R, Van Dyke T, Stashenko P, Sasaki H. Serum Amyloid A Contributes to Chronic Apical Periodontitis via TLR2 and TLR4. J Dent Res. 2019 Jan; 98(1):117-125. PMID: 30189157.
    Citations:    Fields:    
  4. Movila A, Kajiya M, Wisitrasameewong W, Stashenko P, Vardar-Sengul S, Hernandez M, Thomas Temple H, Kawai T. Intravital endoscopic technology for real-time monitoring of inflammation caused in experimental periodontitis. J Immunol Methods. 2018 Jun; 457:26-29. PMID: 29567043.
    Citations:    Fields:    
  5. Colombo APV, Paster BJ, Grimaldi G, Lourenço TGB, Teva A, Campos-Neto A, McCluskey J, Kleanthous H, Van Dyke TE, Stashenko P. Clinical and microbiological parameters of naturally occurring periodontitis in the non-human primate Macaca mulatta. J Oral Microbiol. 2017; 9(1):1403843. PMID: 29805776.
    Citations:    
  6. Youssef H, Stashenko P. Interleukin-1 and estrogen protect against disseminating dentoalveolar infections. Int J Oral Sci. 2017 03; 9(1):16-23. PMID: 28358036.
    Citations: 1     Fields:    Translation:Animals
  7. Rider D, Furusho H, Xu S, Trachtenberg AJ, Kuo WP, Hirai K, Susa M, Bahammam L, Stashenko P, Fujimura A, Sasaki H. Elevated CD14 (Cluster of Differentiation 14) and Toll-Like Receptor (TLR) 4 Signaling Deteriorate Periapical Inflammation in TLR2 Deficient Mice. Anat Rec (Hoboken). 2016 09; 299(9):1281-92. PMID: 27314637.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Daifalla N, Cayabyab MJ, Xie E, Kim HB, Tzipori S, Stashenko P, Duncan M, Campos-Neto A. Commensal Streptococcus mitis is a unique vector for oral mucosal vaccination. Microbes Infect. 2015 Mar; 17(3):237-42. PMID: 25522856.
    Citations: 7     Fields:    Translation:AnimalsCellsPHPublic Health
  9. AlShwaimi E, Berggreen E, Furusho H, Rossall JC, Dobeck J, Yoganathan S, Stashenko P, Sasaki H. IL-17 receptor A signaling is protective in infection-stimulated periapical bone destruction. J Immunol. 2013 Aug 15; 191(4):1785-91. PMID: 23863904.
    Citations: 11     Fields:    Translation:AnimalsCells
  10. Jiang H, Chen W, Zhu G, Zhang L, Tucker B, Hao L, Feng S, Ci H, Ma J, Wang L, Stashenko P, Li YP. RNAi-mediated silencing of Atp6i and Atp6i haploinsufficiency prevents both bone loss and inflammation in a mouse model of periodontal disease. PLoS One. 2013; 8(4):e58599. PMID: 23577057.
    Citations: 11     Fields:    Translation:AnimalsCells
  11. Ma J, Chen W, Zhang L, Tucker B, Zhu G, Sasaki H, Hao L, Wang L, Ci H, Jiang H, Stashenko P, Li YP. RNA interference-mediated silencing of Atp6i prevents both periapical bone erosion and inflammation in the mouse model of endodontic disease. Infect Immun. 2013 Apr; 81(4):1021-30. PMID: 23166162.
    Citations: 9     Fields:    Translation:AnimalsCells
  12. Gao B, Chen W, Hao L, Zhu G, Feng S, Ci H, Zhou X, Stashenko P, Li YP. Inhibiting periapical lesions through AAV-RNAi silencing of cathepsin K. J Dent Res. 2013 Feb; 92(2):180-6. PMID: 23166044.
    Citations: 9     Fields:    Translation:AnimalsCells
  13. Silva MJ, Kajiya M, AlShwaimi E, Sasaki H, Hong J, Ok P, Rezende TM, Pagonis TC, White RR, Paster BJ, Stashenko P, Kawai T. Bacteria-reactive immune response may induce RANKL-expressing T cells in the mouse periapical bone loss lesion. J Endod. 2012 Mar; 38(3):346-50. PMID: 22341072.
    Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
  14. Morse LR, Xu Y, Solomon B, Boyle L, Yoganathan S, Stashenko P, Battaglino RA. Severe Spinal Cord Injury Causes Immediate Multi-cellular Dysfunction at the Chondro-Osseous Junction. Transl Stroke Res. 2011 Dec 01; 2(4):643-50. PMID: 22368723.
    Citations: 3     Fields:    
  15. Ohta K, Laborde NJ, Kajiya M, Shin J, Zhu T, Thondukolam AK, Min C, Kamata N, Karimbux NY, Stashenko P, Kawai T. Expression and possible immune-regulatory function of ghrelin in oral epithelium. J Dent Res. 2011 Nov; 90(11):1286-92. PMID: 21865591.
    Citations: 9     Fields:    Translation:HumansCells
  16. Franco GC, Kajiya M, Nakanishi T, Ohta K, Rosalen PL, Groppo FC, Ernst CW, Boyesen JL, Bartlett JD, Stashenko P, Taubman MA, Kawai T. Inhibition of matrix metalloproteinase-9 activity by doxycycline ameliorates RANK ligand-induced osteoclast differentiation in vitro and in vivo. Exp Cell Res. 2011 Jun 10; 317(10):1454-64. PMID: 21420951.
    Citations: 12     Fields:    Translation:AnimalsCells
  17. Ng R, Singh F, Papamanou DA, Song X, Patel C, Holewa C, Patel N, Klepac-Ceraj V, Fontana CR, Kent R, Pagonis TC, Stashenko PP, Soukos NS. Endodontic photodynamic therapy ex vivo. J Endod. 2011 Feb; 37(2):217-22. PMID: 21238805.
    Citations: 23     Fields:    Translation:HumansCellsPHPublic Health
  18. Sasaki H, Suzuki N, Alshwaimi E, Xu Y, Battaglino R, Morse L, Stashenko P. 18ß-glycyrrhetinic acid inhibits periodontitis via glucocorticoid-independent nuclear factor-?B inactivation in interleukin-10-deficient mice. J Periodontal Res. 2010 Dec; 45(6):757-63. PMID: 20682015.
    Citations: 7     Fields:    Translation:AnimalsCells
  19. Stashenko P, Van Dyke T, Tully P, Kent R, Sonis S, Tanner AC. Inflammation and genetic risk indicators for early periodontitis in adults. J Periodontol. 2011 Apr; 82(4):588-96. PMID: 21054222.
    Citations: 5     Fields:    Translation:Humans
  20. Huang X, Morse LR, Xu Y, Zahradka J, Sychrová H, Stashenko P, Fan F, Battaglino RA. Mutational analysis of NHAoc/NHA2 in Saccharomyces cerevisiae. Biochim Biophys Acta. 2010 Dec; 1800(12):1241-7. PMID: 20713131.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  21. Xu Y, Morse LR, da Silva RA, Odgren PR, Sasaki H, Stashenko P, Battaglino RA. PAMM: a redox regulatory protein that modulates osteoclast differentiation. Antioxid Redox Signal. 2010 Jul 01; 13(1):27-37. PMID: 19951071.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  22. AlShwaimi E, Purcell P, Kawai T, Sasaki H, Oukka M, Campos-Neto A, Stashenko P. Regulatory T cells in mouse periapical lesions. J Endod. 2009 Sep; 35(9):1229-33. PMID: 19720221.
    Citations: 8     Fields:    Translation:AnimalsCells
  23. Sasaki H, Suzuki N, Kent R, Kawashima N, Takeda J, Stashenko P. T cell response mediated by myeloid cell-derived IL-12 is responsible for Porphyromonas gingivalis-induced periodontitis in IL-10-deficient mice. J Immunol. 2008 May 01; 180(9):6193-8. PMID: 18424741.
    Citations: 17     Fields:    Translation:AnimalsCells
  24. Fimple JL, Fontana CR, Foschi F, Ruggiero K, Song X, Pagonis TC, Tanner AC, Kent R, Doukas AG, Stashenko PP, Soukos NS. Photodynamic treatment of endodontic polymicrobial infection in vitro. J Endod. 2008 Jun; 34(6):728-34. PMID: 18498901.
    Citations: 46     Fields:    Translation:HumansCells
  25. Leshem O, Kashino SS, Gonçalves RB, Suzuki N, Onodera M, Fujimura A, Sasaki H, Stashenko P, Campos-Neto A. Th1 biased response to a novel Porphyromonas gingivalis protein aggravates bone resorption caused by this oral pathogen. Microbes Infect. 2008 May; 10(6):664-72. PMID: 18457976.
    Citations: 2     Fields:    Translation:AnimalsCells
  26. Morse LR, Nguyen HP, Jain N, Williams S, Tun CG, Battaglino RA, Stashenko P, Garshick E. Age and motor score predict osteoprotegerin level in chronic spinal cord injury. J Musculoskelet Neuronal Interact. 2008 Jan-Mar; 8(1):50-7. PMID: 18398265.
    Citations: 4     Fields:    Translation:Humans
  27. Foschi F, Fontana CR, Ruggiero K, Riahi R, Vera A, Doukas AG, Pagonis TC, Kent R, Stashenko PP, Soukos NS. Photodynamic inactivation of Enterococcus faecalis in dental root canals in vitro. Lasers Surg Med. 2007 Dec; 39(10):782-7. PMID: 18081066.
    Citations: 23     Fields:    Translation:HumansCells
  28. Morse L, Teng YD, Pham L, Newton K, Yu D, Liao WL, Kohler T, Müller R, Graves D, Stashenko P, Battaglino R. Spinal cord injury causes rapid osteoclastic resorption and growth plate abnormalities in growing rats (SCI-induced bone loss in growing rats). Osteoporos Int. 2008 May; 19(5):645-52. PMID: 17987335.
    Citations: 15     Fields:    Translation:AnimalsCells
  29. Yang S, Chen W, Stashenko P, Li YP. Specificity of RGS10A as a key component in the RANKL signaling mechanism for osteoclast differentiation. J Cell Sci. 2007 Oct 01; 120(Pt 19):3362-71. PMID: 17881498.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  30. Battaglino RA, Pham L, Morse LR, Vokes M, Sharma A, Odgren PR, Yang M, Sasaki H, Stashenko P. NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts. Bone. 2008 Jan; 42(1):180-92. PMID: 17988971.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  31. Schulze-Späte U, Battaglino R, Fu J, Sharma A, Vokes M, Stashenko P. Brn3 transcription factors control terminal osteoclastogenesis. J Cell Biochem. 2007 Sep 01; 102(1):1-12. PMID: 17668438.
    Citations: 1     Fields:    Translation:AnimalsCells
  32. Pham L, Purcell P, Morse L, Stashenko P, Battaglino RA. Expression analysis of nha-oc/NHA2: a novel gene selectively expressed in osteoclasts. Gene Expr Patterns. 2007 Oct; 7(8):846-51. PMID: 17698421.
    Citations: 7     Fields:    Translation:AnimalsCells
  33. Kawai T, Paster BJ, Komatsuzawa H, Ernst CW, Goncalves RB, Sasaki H, Ouhara K, Stashenko PP, Sugai M, Taubman MA. Cross-reactive adaptive immune response to oral commensal bacteria results in an induction of receptor activator of nuclear factor-kappaB ligand (RANKL)-dependent periodontal bone resorption in a mouse model. Oral Microbiol Immunol. 2007 Jun; 22(3):208-15. PMID: 17488448.
    Citations: 15     Fields:    Translation:AnimalsCells
  34. Battaglino R, Vokes M, Schulze-Späte U, Sharma A, Graves D, Kohler T, Müller R, Yoganathan S, Stashenko P. Fluoxetine treatment increases trabecular bone formation in mice. J Cell Biochem. 2007 Apr 15; 100(6):1387-94. PMID: 17041947.
    Citations: 23     Fields:    Translation:AnimalsCells
  35. Keles A, Grunes B, Difuria C, Gagari E, Srinivasan V, Darendeliler MA, Muller R, Kent R, Stashenko P. Inhibition of tooth movement by osteoprotegerin vs. pamidronate under conditions of constant orthodontic force. Eur J Oral Sci. 2007 Apr; 115(2):131-6. PMID: 17451503.
    Citations: 9     Fields:    Translation:AnimalsCells
  36. Ernst CW, Lee JE, Nakanishi T, Karimbux NY, Rezende TM, Stashenko P, Seki M, Taubman MA, Kawai T. Diminished forkhead box P3/CD25 double-positive T regulatory cells are associated with the increased nuclear factor-kappaB ligand (RANKL+) T cells in bone resorption lesion of periodontal disease. Clin Exp Immunol. 2007 May; 148(2):271-80. PMID: 17355249.
    Citations: 18     Fields:    Translation:HumansCells
  37. Stashenko P, Gonçalves RB, Lipkin B, Ficarelli A, Sasaki H, Campos-Neto A. Th1 immune response promotes severe bone resorption caused by Porphyromonas gingivalis. Am J Pathol. 2007 Jan; 170(1):203-13. PMID: 17200194.
    Citations: 19     Fields:    Translation:AnimalsCells
  38. Foschi F, Izard J, Sasaki H, Sambri V, Prati C, Müller R, Stashenko P. Treponema denticola in disseminating endodontic infections. J Dent Res. 2006 Aug; 85(8):761-5. PMID: 16861296.
    Citations: 12     Fields:    Translation:AnimalsCells
  39. Soukos NS, Chen PS, Morris JT, Ruggiero K, Abernethy AD, Som S, Foschi F, Doucette S, Bammann LL, Fontana CR, Doukas AG, Stashenko PP. Photodynamic therapy for endodontic disinfection. J Endod. 2006 Oct; 32(10):979-84. PMID: 16982278.
    Citations: 43     Fields:    Translation:HumansCellsPHPublic Health
  40. Gonçalves RB, Leshem O, Bernards K, Webb JR, Stashenko PP, Campos-Neto A. T-cell expression cloning of Porphyromonas gingivalis genes coding for T helper-biased immune responses during infection. Infect Immun. 2006 Jul; 74(7):3958-66. PMID: 16790769.
    Citations: 5     Fields:    Translation:AnimalsCells
  41. Foschi F, Cavrini F, Montebugnoli L, Stashenko P, Sambri V, Prati C. Detection of bacteria in endodontic samples by polymerase chain reaction assays and association with defined clinical signs in Italian patients. Oral Microbiol Immunol. 2005 Oct; 20(5):289-95. PMID: 16101964.
    Citations: 15     Fields:    Translation:HumansCells
  42. Gyurko R, Shoji H, Battaglino RA, Boustany G, Gibson FC, Genco CA, Stashenko P, Van Dyke TE. Inducible nitric oxide synthase mediates bone development and P. gingivalis-induced alveolar bone loss. Bone. 2005 Mar; 36(3):472-9. PMID: 15777672.
    Citations: 12     Fields:    Translation:AnimalsCells
  43. Sasaki H, Okamatsu Y, Kawai T, Kent R, Taubman M, Stashenko P. The interleukin-10 knockout mouse is highly susceptible to Porphyromonas gingivalis-induced alveolar bone loss. J Periodontal Res. 2004 Dec; 39(6):432-41. PMID: 15491348.
    Citations: 42     Fields:    Translation:AnimalsCells
  44. Dayan S, Stashenko P, Niederman R, Kupper TS. Oral epithelial overexpression of IL-1alpha causes periodontal disease. J Dent Res. 2004 Oct; 83(10):786-90. PMID: 15381720.
    Citations: 9     Fields:    Translation:AnimalsCells
  45. Castro GF, Souza IP, Lopes S, Stashenko P, Teles RP. Salivary IgA to cariogenic bacteria in HIV-positive children and its correlation with caries prevalence and levels of cariogenic microorganisms. Oral Microbiol Immunol. 2004 Oct; 19(5):281-8. PMID: 15327638.
    Citations: 2     Fields:    Translation:HumansCells
  46. Okamatsu Y, Kim D, Battaglino R, Sasaki H, Späte U, Stashenko P. MIP-1 gamma promotes receptor-activator-of-NF-kappa-B-ligand-induced osteoclast formation and survival. J Immunol. 2004 Aug 01; 173(3):2084-90. PMID: 15265944.
    Citations: 26     Fields:    Translation:AnimalsCells
  47. Battaglino R, Fu J, Späte U, Ersoy U, Joe M, Sedaghat L, Stashenko P. Serotonin regulates osteoclast differentiation through its transporter. J Bone Miner Res. 2004 Sep; 19(9):1420-31. PMID: 15312242.
    Citations: 56     Fields:    Translation:AnimalsCells
  48. Sasaki H, Balto K, Kawashima N, Eastcott J, Hoshino K, Akira S, Stashenko P. Gamma interferon (IFN-gamma) and IFN-gamma-inducing cytokines interleukin-12 (IL-12) and IL-18 do not augment infection-stimulated bone resorption in vivo. Clin Diagn Lab Immunol. 2004 Jan; 11(1):106-10. PMID: 14715554.
    Citations: 13     Fields:    Translation:AnimalsCells
  49. von Stechow D, Balto K, Stashenko P, Müller R. Three-dimensional quantitation of periradicular bone destruction by micro-computed tomography. J Endod. 2003 Apr; 29(4):252-6. PMID: 12701773.
    Citations: 7     Fields:    Translation:Animals
  50. Stashenko P, Niederman R, DePaola D. Basic and clinical research: issues of cost, manpower needs, and infrastructure. J Dent Educ. 2002 Aug; 66(8):927-38; discussion 939-41. PMID: 12214841.
    Citations:    Fields:    Translation:Humans
  51. Niederman R, Kelderman H, Socransky S, Ostroff G, Genco C, Kent R, Stashenko P. Enhanced neutrophil emigration and Porphyromonas gingivalis reduction following PGG-glucan treatment of mice. Arch Oral Biol. 2002 Aug; 47(8):613-8. PMID: 12221019.
    Citations: 4     Fields:    Translation:AnimalsCells
  52. Battaglino R, Kim D, Fu J, Vaage B, Fu XY, Stashenko P. c-myc is required for osteoclast differentiation. J Bone Miner Res. 2002 May; 17(5):763-73. PMID: 12009006.
    Citations: 18     Fields:    Translation:AnimalsCells
  53. Balto K, White R, Mueller R, Stashenko P. A mouse model of inflammatory root resorption induced by pulpal infection. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Apr; 93(4):461-8. PMID: 12029286.
    Citations: 1     Fields:    Translation:AnimalsCells
  54. Niederman R, Westernoff T, Lee C, Mark LL, Kawashima N, Ullman-Culler M, Dewhirst FE, Paster BJ, Wagner DD, Mayadas T, Hynes RO, Stashenko P. Infection-mediated early-onset periodontal disease in P/E-selectin-deficient mice. J Clin Periodontol. 2001 Jun; 28(6):569-75. PMID: 11350525.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  55. Deng W, Stashenko P, Chen W, Liang Y, Shimizu K, Li YP. Characterization of mouse Atp6i gene, the gene promoter, and the gene expression. J Bone Miner Res. 2001 Jun; 16(6):1136-46. PMID: 11393791.
    Citations: 1     Fields:    Translation:AnimalsCells
  56. Balto K, Sasaki H, Stashenko P. Interleukin-6 deficiency increases inflammatory bone destruction. Infect Immun. 2001 Feb; 69(2):744-50. PMID: 11159963.
    Citations: 27     Fields:    Translation:AnimalsCells
  57. Sasaki H, Hou L, Belani A, Wang CY, Uchiyama T, Müller R, Stashenko P. IL-10, but not IL-4, suppresses infection-stimulated bone resorption in vivo. J Immunol. 2000 Oct 01; 165(7):3626-30. PMID: 11034365.
    Citations: 49     Fields:    Translation:AnimalsCells
  58. Hou L, Sasakj H, Stashenko P. B-Cell deficiency predisposes mice to disseminating anaerobic infections: protection by passive antibody transfer. Infect Immun. 2000 Oct; 68(10):5645-51. PMID: 10992465.
    Citations: 11     Fields:    Translation:AnimalsCells
  59. Hou L, Sasaki H, Stashenko P. Toll-like receptor 4-deficient mice have reduced bone destruction following mixed anaerobic infection. Infect Immun. 2000 Aug; 68(8):4681-7. PMID: 10899873.
    Citations: 23     Fields:    Translation:AnimalsCells
  60. Mark LL, Haffajee AD, Socransky SS, Kent RL, Guerrero D, Kornman K, Newman M, Stashenko P. Effect of the interleukin-1 genotype on monocyte IL-1beta expression in subjects with adult periodontitis. J Periodontal Res. 2000 Jun; 35(3):172-7. PMID: 10929872.
    Citations: 9     Fields:    Translation:HumansCells
  61. Balto K, Müller R, Carrington DC, Dobeck J, Stashenko P. Quantification of periapical bone destruction in mice by micro-computed tomography. J Dent Res. 2000 Jan; 79(1):35-40. PMID: 10690658.
    Citations: 19     Fields:    Translation:Animals
  62. Li YP, Chen W, Liang Y, Li E, Stashenko P. Atp6i-deficient mice exhibit severe osteopetrosis due to loss of osteoclast-mediated extracellular acidification. Nat Genet. 1999 Dec; 23(4):447-51. PMID: 10581033.
    Citations: 110     Fields:    Translation:AnimalsCells
  63. Gilad JZ, Teles R, Goodson M, White RR, Stashenko P. Development of a clindamycin-impregnated fiber as an intracanal medication in endodontic therapy. J Endod. 1999 Nov; 25(11):722-7. PMID: 10726537.
    Citations: 5     Fields:    Translation:HumansCells
  64. Kawashima N, Niederman R, Hynes RO, Ullmann-Cullere M, Stashenko P. Infection-stimulated infraosseus inflammation and bone destruction is increased in P-/E-selectin knockout mice. Immunology. 1999 May; 97(1):117-23. PMID: 10447722.
    Citations: 9     Fields:    Translation:AnimalsCells
  65. Kawashima N, Stashenko P. Expression of bone-resorptive and regulatory cytokines in murine periapical inflammation. Arch Oral Biol. 1999 Jan; 44(1):55-66. PMID: 10075151.
    Citations: 20     Fields:    Translation:AnimalsCells
  66. Yelick PC, Abduljabbar TS, Stashenko P. zALK-8, a novel type I serine/threonine kinase receptor, is expressed throughout early zebrafish development. Dev Dyn. 1998 Apr; 211(4):352-61. PMID: 9566954.
    Citations: 5     Fields:    Translation:AnimalsCells
  67. Stashenko P. Alumni Day '98 Symposium. The "M" in D.M.D.: new horizons in oral medicine in the 21st century. Harv Dent Bull. 1998; 7(2):15. PMID: 11820125.
    Citations:    Fields:    Translation:Humans
  68. Stashenko P, Teles R, D'Souza R. Periapical inflammatory responses and their modulation. Crit Rev Oral Biol Med. 1998; 9(4):498-521. PMID: 9825224.
    Citations: 33     Fields:    Translation:HumansCells
  69. Teles R, Wang CY, Stashenko P. Increased susceptibility of RAG-2 SCID mice to dissemination of endodontic infections. Infect Immun. 1997 Sep; 65(9):3781-7. PMID: 9284152.
    Citations: 11     Fields:    Translation:AnimalsCells
  70. Wang CY, Tani-Ishii N, Stashenko P. Bone-resorptive cytokine gene expression in periapical lesions in the rat. Oral Microbiol Immunol. 1997 Apr; 12(2):65-71. PMID: 9227128.
    Citations: 10     Fields:    Translation:AnimalsCells
  71. Petit MD, Stashenko P. Extracts of periodontopathic microorganisms lack functional superantigenic activity for murine T cells. J Periodontal Res. 1996 Nov; 31(8):517-24. PMID: 8971649.
    Citations: 1     Fields:    Translation:AnimalsCells
  72. Yelick PC, Driever W, Neuhauss S, Stashenko P. Craniofacial cartilage development in zebrafish. Ann N Y Acad Sci. 1996 Jun 08; 785:360-1. PMID: 8702181.
    Citations:    Fields:    Translation:AnimalsCells
  73. Li YP, Chen W, Stashenko P. Molecular cloning and characterization of a putative novel human osteoclast-specific 116-kDa vacuolar proton pump subunit. Biochem Biophys Res Commun. 1996 Jan 26; 218(3):813-21. PMID: 8579597.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  74. Li YP, Chen W, Stashenko P. Characterization of a silencer element in the first exon of the human osteocalcin gene. Nucleic Acids Res. 1995 Dec 25; 23(24):5064-72. PMID: 8559666.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  75. Li YP, Alexander M, Wucherpfennig AL, Yelick P, Chen W, Stashenko P. Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas. J Bone Miner Res. 1995 Aug; 10(8):1197-202. PMID: 8585423.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  76. Tani-Ishii N, Wang CY, Stashenko P. Immunolocalization of bone-resorptive cytokines in rat pulp and periapical lesions following surgical pulp exposure. Oral Microbiol Immunol. 1995 Aug; 10(4):213-9. PMID: 8602333.
    Citations: 24     Fields:    Translation:AnimalsCells
  77. Rahimi P, Wang CY, Stashenko P, Lee SK, Lorenzo JA, Graves DT. Monocyte chemoattractant protein-1 expression and monocyte recruitment in osseous inflammation in the mouse. Endocrinology. 1995 Jun; 136(6):2752-9. PMID: 7750500.
    Citations: 19     Fields:    Translation:AnimalsCells
  78. Campos-Neto A, Mengel JO, Oliveira-Silva DA, Bonini PV, Taketomi E, Stashenko PP. Potent stimulation of murine B cells to proliferate and to secrete immunoglobulins by a lipoteichoic acid-like molecule produced by Clostridium botulinum C and D. Braz J Med Biol Res. 1995 May; 28(5):575-84. PMID: 8555978.
    Citations:    Fields:    Translation:AnimalsCells
  79. Stashenko P, Wang CY, Riley E, Wu Y, Ostroff G, Niederman R. Reduction of infection-stimulated periapical bone resorption by the biological response modifier PGG glucan. J Dent Res. 1995 Jan; 74(1):323-30. PMID: 7876425.
    Citations: 9     Fields:    Translation:AnimalsCells
  80. Stashenko P, Wang CY, Tani-Ishii N, Yu SM. Pathogenesis of induced rat periapical lesions. Oral Surg Oral Med Oral Pathol. 1994 Oct; 78(4):494-502. PMID: 7800381.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  81. Tani-Ishii N, Wang CY, Tanner A, Stashenko P. Changes in root canal microbiota during the development of rat periapical lesions. Oral Microbiol Immunol. 1994 Jun; 9(3):129-35. PMID: 7936717.
    Citations: 4     Fields:    Translation:AnimalsCells
  82. Wucherpfennig AL, Li YP, Stetler-Stevenson WG, Rosenberg AE, Stashenko P. Expression of 92 kD type IV collagenase/gelatinase B in human osteoclasts. J Bone Miner Res. 1994 Apr; 9(4):549-56. PMID: 8030443.
    Citations: 17     Fields:    Translation:HumansCells
  83. Li YP, Stashenko P. Characterization of a tumor necrosis factor-responsive element which down-regulates the human osteocalcin gene. Mol Cell Biol. 1993 Jun; 13(6):3714-21. PMID: 8388544.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  84. Wang CY, Stashenko P. Characterization of bone-resorbing activity in human periapical lesions. J Endod. 1993 Mar; 19(3):107-11. PMID: 8509747.
    Citations: 7     Fields:    Translation:HumansAnimals
  85. Wang CY, Stashenko P. The role of interleukin-1 alpha in the pathogenesis of periapical bone destruction in a rat model system. Oral Microbiol Immunol. 1993 Feb; 8(1):50-6. PMID: 8510985.
    Citations: 18     Fields:    Translation:Animals
  86. Wucherpfennig AL, Dewhirst FE, Stashenko P. Platelet activating factor increases intracellular calcium in isolated osteoclasts but does not modify bone resorption. Bone. 1993; 14(1):13-8. PMID: 8442997.
    Citations: 1     Fields:    Translation:AnimalsCells
  87. Stashenko P, Yu SM, Wang CY. Kinetics of immune cell and bone resorptive responses to endodontic infections. J Endod. 1992 Sep; 18(9):422-6. PMID: 9796508.
    Citations: 12     Fields:    Translation:AnimalsCells
  88. Li YP, Stashenko P. Proinflammatory cytokines tumor necrosis factor-alpha and IL-6, but not IL-1, down-regulate the osteocalcin gene promoter. J Immunol. 1992 Feb 01; 148(3):788-94. PMID: 1309841.
    Citations: 18     Fields:    Translation:Cells
  89. Stashenko P, Wang CY. Characterization of bone resorptive mediators in active periapical lesions. Proc Finn Dent Soc. 1992; 88 Suppl 1:427-32. PMID: 1508901.
    Citations: 1     Fields:    Translation:Animals
  90. Wang CY, Stashenko P. Kinetics of bone-resorbing activity in developing periapical lesions. J Dent Res. 1991 Oct; 70(10):1362-6. PMID: 1939830.
    Citations: 5     Fields:    Translation:Animals
  91. Stashenko P, Jandinski JJ, Fujiyoshi P, Rynar J, Socransky SS. Tissue levels of bone resorptive cytokines in periodontal disease. J Periodontol. 1991 Aug; 62(8):504-9. PMID: 1920018.
    Citations: 49     Fields:    Translation:Humans
  92. Stashenko P, Fujiyoshi P, Obernesser MS, Prostak L, Haffajee AD, Socransky SS. Levels of interleukin 1 beta in tissue from sites of active periodontal disease. J Clin Periodontol. 1991 Aug; 18(7):548-54. PMID: 1894750.
    Citations: 44     Fields:    Translation:Humans
  93. Nguyen L, Dewhirst FE, Hauschka PV, Stashenko P. Interleukin-1 beta stimulates bone resorption and inhibits bone formation in vivo. Lymphokine Cytokine Res. 1991 Apr; 10(1-2):15-21. PMID: 1873357.
    Citations: 31     Fields:    Translation:Animals
  94. Eftimiadi C, Stashenko P, Tonetti M, Mangiante PE, Massara R, Zupo S, Ferrarini M. Divergent effect of the anaerobic bacteria by-product butyric acid on the immune response: suppression of T-lymphocyte proliferation and stimulation of interleukin-1 beta production. Oral Microbiol Immunol. 1991 Feb; 6(1):17-23. PMID: 1945479.
    Citations: 5     Fields:    Translation:Cells
  95. Jandinski JJ, Stashenko P, Feder LS, Leung CC, Peros WJ, Rynar JE, Deasy MJ. Localization of interleukin-1 beta in human periodontal tissue. J Periodontol. 1991 Jan; 62(1):36-43. PMID: 2002430.
    Citations: 8     Fields:    Translation:HumansCells
  96. Obernesser MS, Socransky SS, Stashenko P. Limit of resolution of flow cytometry for the detection of selected bacterial species. J Dent Res. 1990 Sep; 69(9):1592-8. PMID: 1697868.
    Citations: 2     Fields:    Translation:Cells
  97. Dewhirst FE, Ago JM, Stashenko P. Interleukin 1 interacts synergistically with forskolin and isobutylmethylxanthine in stimulating bone resorption in organ culture. Calcif Tissue Int. 1990 Jul; 47(1):1-7. PMID: 1695117.
    Citations:    Fields:    Translation:AnimalsCells
  98. Stashenko P. Role of immune cytokines in the pathogenesis of periapical lesions. Endod Dent Traumatol. 1990 Jun; 6(3):89-96. PMID: 2079017.
    Citations: 9     Fields:    Translation:HumansCells
  99. Stashenko P, Yu SM. T helper and T suppressor cell reversal during the development of induced rat periapical lesions. J Dent Res. 1989 May; 68(5):830-4. PMID: 2523917.
    Citations: 9     Fields:    Translation:AnimalsCells
  100. Stashenko P, Obernesser MS, Dewhirst FE. Effect of immune cytokines on bone. Immunol Invest. 1989 Jan-May; 18(1-4):239-49. PMID: 2659511.
    Citations: 9     Fields:    Translation:AnimalsCells
  101. Campos-Neto A, Stashenko PP. Interleukin 1 and T-cell activation. Immunol Today. 1988 May; 9(5):131. PMID: 3267173.
    Citations: 1     Fields:    Translation:AnimalsCells
  102. Stashenko P, Dewhirst FE, Rooney ML, Desjardins LA, Heeley JD. Interleukin-1 beta is a potent inhibitor of bone formation in vitro. J Bone Miner Res. 1987 Dec; 2(6):559-65. PMID: 3502684.
    Citations: 48     Fields:    Translation:AnimalsCells
  103. Yu SM, Stashenko P. Identification of inflammatory cells in developing rat periapical lesions. J Endod. 1987 Nov; 13(11):535-40. PMID: 3482098.
    Citations: 5     Fields:    Translation:AnimalsCells
  104. Stoufi ED, Taubman MA, Ebersole JL, Smith DJ, Stashenko PP. Phenotypic analyses of mononuclear cells recovered from healthy and diseased human periodontal tissues. J Clin Immunol. 1987 May; 7(3):235-45. PMID: 3496355.
    Citations: 14     Fields:    Translation:HumansCells
  105. Dewhirst FE, Ago JM, Peros WJ, Stashenko P. Synergism between parathyroid hormone and interleukin 1 in stimulating bone resorption in organ culture. J Bone Miner Res. 1987 Apr; 2(2):127-34. PMID: 3502666.
    Citations: 13     Fields:    Translation:Animals
  106. Stashenko P, Dewhirst FE, Peros WJ, Kent RL, Ago JM. Synergistic interactions between interleukin 1, tumor necrosis factor, and lymphotoxin in bone resorption. J Immunol. 1987 Mar 01; 138(5):1464-8. PMID: 3492553.
    Citations: 71     Fields:    Translation:HumansAnimals
  107. Stashenko P, Peros WJ, Gibbons RJ, Dearborn SM. Effect of monoclonal antibodies against lipoteichoic acid from the oral bacterium Streptococcus mutans on its adhesion and plaque-accumulation in vitro. Arch Oral Biol. 1986; 31(7):455-61. PMID: 3467668.
    Citations: 1     Fields:    Translation:Cells
  108. Dewhirst FE, Stashenko PP, Mole JE, Tsurumachi T. Purification and partial sequence of human osteoclast-activating factor: identity with interleukin 1 beta. J Immunol. 1985 Oct; 135(4):2562-8. PMID: 3875658.
    Citations: 74     Fields:    Translation:HumansCells
  109. Stashenko P, Resmini LM, Haffajee AD, Socransky SS. Helper and suppressor T cells in periodontal disease. J Periodontal Res. 1985 Sep; 20(5):515-21. PMID: 2934536.
    Citations: 3     Fields:    Translation:HumansCells
  110. Stashenko P, Resmini LM, Haffajee AD, Socransky SS. T cell responses of periodontal disease patients and healthy subjects to oral microorganisms. J Periodontal Res. 1983 Nov; 18(6):587-600. PMID: 6230432.
    Citations: 4     Fields:    Translation:HumansCells
  111. Stashenko P. Regulatory effect of monocytes on T cell proliferative responses to oral microbial antigens. Infect Immun. 1982 Dec; 38(3):938-47. PMID: 6984019.
    Citations: 3     Fields:    Translation:HumansCells
  112. Bhan AK, Nadler LM, Stashenko P, McCluskey RT, Schlossman SF. Stages of B cell differentiation in human lymphoid tissue. J Exp Med. 1981 Sep 01; 154(3):737-49. PMID: 7024458.
    Citations: 58     Fields:    Translation:HumansCells
  113. Pesando JM, Nadler LM, Lazarus H, Tomaselli KJ, Stashenko P, Ritz J, Levine H, Yunis EJ, Schlossman SF. Human cell lines express multiple populations of Ia-like molecules. Hum Immunol. 1981 Aug; 3(1):67-76. PMID: 6974160.
    Citations: 3     Fields:    Translation:HumansCells
  114. Stashenko P, Nadler LM, Hardy R, Schlossman SF. Expression of cell surface markers after human B lymphocyte activation. Proc Natl Acad Sci U S A. 1981 Jun; 78(6):3848-52. PMID: 6973760.
    Citations: 49     Fields:    Translation:HumansCells
  115. Nadler LM, Stashenko P, Hardy R, van Agthoven A, Terhorst C, Schlossman SF. Characterization of a human B cell-specific antigen (B2) distinct from B1. J Immunol. 1981 May; 126(5):1941-7. PMID: 6163824.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  116. Nadler LM, Stashenko P, Hardy R, Tomaselli KJ, Yunis EJ, Schlossman SF, Pesando JM. Monoclonal antibody identifies a new Ia-like (p29,34) polymorphic system linked to the HLA-D/DR region. Nature. 1981 Apr 16; 290(5807):591-3. PMID: 6163992.
    Citations: 20     Fields:    Translation:HumansCells
  117. Nadler LM, Stashenko P, Hardy R, Pesando JM, Yunis EJ, Schlossman SF. Monoclonal antibodies defining serologically distinct HLA-D/DR related Ia-like antigens in man. Hum Immunol. 1981 Feb; 2(1):77-90. PMID: 6944297.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  118. Nadler LM, Ritz J, Hardy R, Pesando JM, Schlossman SF, Stashenko P. A unique cell surface antigen identifying lymphoid malignancies of B cell origin. J Clin Invest. 1981 Jan; 67(1):134-40. PMID: 6969730.
    Citations: 61     Fields:    Translation:HumansCells
  119. Stashenko P, Nadler LM, Hardy R, Schlossman SF. Characterization of a human B lymphocyte-specific antigen. J Immunol. 1980 Oct; 125(4):1678-85. PMID: 6157744.
    Citations: 203     Fields:    Translation:HumansAnimalsCells
  120. Nadler LM, Stashenko P, Hardy R, Kaplan WD, Button LN, Kufe DW, Antman KH, Schlossman SF. Serotherapy of a patient with a monoclonal antibody directed against a human lymphoma-associated antigen. Cancer Res. 1980 Sep; 40(9):3147-54. PMID: 7427932.
    Citations: 53     Fields:    Translation:HumansCells
  121. Stashenko P, Klinman NR. Analysis of the primary anti-(4-hydroxy-3-nitrophenyl) acetyl (NP) responsive B cells in BALB/C and B10.D2 mice. J Immunol. 1980 Aug; 125(2):531-7. PMID: 6771327.
    Citations: 9     Fields:    Translation:AnimalsCells
  122. Nadler LM, Stashenko P, Hardy R, Schlossman SF. A monoclonal antibody defining a lymphoma-associated antigen in man. J Immunol. 1980 Aug; 125(2):570-7. PMID: 6156208.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  123. Stashenko PP, Bhan AK, Schlossman SF, McCluskey RT. Local transfer of delayed hypersensitivity and cutaneous basophil hypersensitivity. J Immunol. 1977 Dec; 119(6):1987-93. PMID: 72112.
    Citations: 5     Fields:    Translation:AnimalsCells
  124. Yaron A, Dunham EK, Stashenko PP, Campos-Neto A, Levine H, Schlossman SF. Immune ascites in the guinea pig: specificity of cells and antibody in an induced peritoneal exudate. J Immunol. 1977 Sep; 119(3):968-75. PMID: 70481.
    Citations:    Fields:    Translation:Animals
  125. Stashenko PP, Schlossman SF. Antigen recognition: the specificity of an isolated T lymphocyte population. J Immunol. 1977 Feb; 118(2):544-50. PMID: 65426.
    Citations: 6     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.