Harvard Catalyst Profiles

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Daniel Aeschbach, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL077399 (AESCHBACH, DANIEL) Apr 10, 2005 - Sep 30, 2011
    Neurobiology of Individual Differences in Sleep Duration
    Role: Principal Investigator
  2. P01AG009975 (CZEISLER, CHARLES A) Aug 1, 1991 - Jul 31, 2021
    Sleep, Aging and Circadian Rhythm Disorders
    Role: Co-Principal Investigator
  3. M01RR002635 (GOTTLIEB, GARY L) Dec 1, 1984 - Mar 31, 2010
    General Clinical Research Center
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tu D, Basner M, Smith MG, Williams ES, Ryder VE, Romoser AA, Ecker A, Aeschbach D, Stahn AC, Jones CW, Howard K, Kaizi-Lutu M, Dinges DF, Shou H. Dynamic ensemble prediction of cognitive performance in spaceflight. Sci Rep. 2022 06 30; 12(1):11032. PMID: 35773291; PMCID: PMC9246897.
    Citations:    Fields:    Translation:Humans
  2. Elmenhorst EM, Rooney D, Benderoth S, Wittkowski M, Wenzel J, Aeschbach D. Sleep-Induced Hypoxia under Flight Conditions: Implications and Countermeasures for Long-Haul Flight Crews and Passengers. Nat Sci Sleep. 2022; 14:193-205. PMID: 35177944; PMCID: PMC8846622.
    Citations: 1     
  3. Sanok S, Berger M, Müller U, Schmid M, Weidenfeld S, Elmenhorst EM, Aeschbach D. Road traffic noise impacts sleep continuity in suburban residents: Exposure-response quantification of noise-induced awakenings from vehicle pass-bys at night. Sci Total Environ. 2022 Apr 15; 817:152594. PMID: 34953847.
    Citations:    Fields:    Translation:HumansPHPublic Health
  4. Chellappa SL, Aeschbach D. Sleep and anxiety: From mechanisms to interventions. Sleep Med Rev. 2022 02; 61:101583. PMID: 34979437.
    Citations: 2     Fields:    Translation:Humans
  5. Chellappa SL, Qian J, Vujovic N, Morris CJ, Nedeltcheva A, Nguyen H, Rahman N, Heng SW, Kelly L, Kerlin-Monteiro K, Srivastav S, Wang W, Aeschbach D, Czeisler CA, Shea SA, Adler GK, Garaulet M, Scheer FAJL. Daytime eating prevents internal circadian misalignment and glucose intolerance in night work. Sci Adv. 2021 Dec 03; 7(49):eabg9910. PMID: 34860550; PMCID: PMC8641939.
    Citations: 9     Fields:    
  6. Pierling AL, Elmenhorst EM, Lange D, Hennecke E, Baur DM, Beer S, Kroll T, Neumaier B, Aeschbach D, Bauer A, Landolt HP, Elmenhorst D. Cerebral A1 adenosine receptor availability in female and male participants and its relationship to sleep. Neuroimage. 2021 12 15; 245:118695. PMID: 34732326.
    Citations:    Fields:    Translation:Humans
  7. Smith MG, Younes M, Aeschbach D, Elmenhorst EM, Müller U, Basner M. Traffic noise-induced changes in wake-propensity measured with the Odds-Ratio Product (ORP). Sci Total Environ. 2022 Jan 20; 805:150191. PMID: 34818802.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  8. Prayag AS, Münch M, Aeschbach D, Chellappa SL, Gronfier C. Reply to Bracke et al. Comment on "Prayag et al. Light Modulation of Human Clocks, Wake, and Sleep. Clocks&Sleep 2019, 1, 193-208". Clocks Sleep. 2021 Jul 05; 3(3):398-402. PMID: 34287255.
  9. Quehl J, Bartels S, Fimmers R, Aeschbach D. Effects of Nocturnal Aircraft Noise and Non-Acoustical Factors on Short-Term Annoyance in Primary School Children. Int J Environ Res Public Health. 2021 06 29; 18(13). PMID: 34209699.
    Citations:    Fields:    Translation:HumansPHPublic Health
  10. Weidenfeld S, Sanok S, Fimmers R, Puth MT, Aeschbach D, Elmenhorst EM. Short-Term Annoyance Due to Night-Time Road, Railway, and Air Traffic Noise: Role of the Noise Source, the Acoustical Metric, and Non-Acoustical Factors. Int J Environ Res Public Health. 2021 04 27; 18(9). PMID: 33925579.
    Citations: 1     Fields:    Translation:PHPublic Health
  11. Baur DM, Lange D, Elmenhorst EM, Elmenhorst D, Bauer A, Aeschbach D, Landolt HP. Coffee effectively attenuates impaired attention in ADORA2A C/C-allele carriers during chronic sleep restriction. Prog Neuropsychopharmacol Biol Psychiatry. 2021 07 13; 109:110232. PMID: 33373678.
    Citations: 3     Fields:    Translation:Humans
  12. Hohoff C, Kroll T, Zhao B, Kerkenberg N, Lang I, Schwarte K, Elmenhorst D, Elmenhorst EM, Aeschbach D, Zhang W, Baune BT, Neumaier B, Bauer A, Deckert J. ADORA2A variation and adenosine A1 receptor availability in the human brain with a focus on anxiety-related brain regions: modulation by ADORA1 variation. Transl Psychiatry. 2020 11 24; 10(1):406. PMID: 33235193; PMCID: PMC7686488.
    Citations: 3     Fields:    Translation:Humans
  13. Hennecke E, Lange D, Steenbergen F, Fronczek-Poncelet J, Elmenhorst D, Bauer A, Aeschbach D, Elmenhorst EM. Adverse interaction effects of chronic and acute sleep deficits on spatial working memory but not on verbal working memory or declarative memory. J Sleep Res. 2021 08; 30(4):e13225. PMID: 33169493.
    Citations: 3     Fields:    Translation:Humans
  14. Sallinen M, van Dijk H, Aeschbach D, Maij A, Åkerstedt T. A Large-Scale European Union Study of Aircrew Fatigue During Long Night and Disruptive Duties. Aerosp Med Hum Perform. 2020 Aug 01; 91(8):628-635. PMID: 32693870.
    Citations: 3     Fields:    Translation:Humans
  15. Rooney D, Wittkowski M, Bartels S, Weidenfeld S, Aeschbach D. Influence of transient pressure changes on speech intelligibility: Implications for next-generation train travel. PLoS One. 2020; 15(4):e0232024. PMID: 32324825.
    Citations:    Fields:    Translation:HumansPHPublic Health
  16. Li C, Fronczek-Poncelet J, Lange D, Hennecke E, Kroll T, Matusch A, Aeschbach D, Bauer A, Elmenhorst EM, Elmenhorst D. Impact of acute sleep deprivation on dynamic functional connectivity states. Hum Brain Mapp. 2020 03; 41(4):994-1005. PMID: 31680379.
    Citations: 5     Fields:    Translation:Humans
  17. Rooney D, Herkenrath S, Priegnitz C, Putzke M, Treml M, Wenzel J, Aeschbach D, Randerath W. Choosing an Adequate Test to Determine Fitness for Air Travel in Obese Individuals. Chest. 2019 11; 156(5):926-932. PMID: 31419402.
    Citations: 1     Fields:    Translation:Humans
  18. Chang AM, Duffy JF, Buxton OM, Lane JM, Aeschbach D, Anderson C, Bjonnes AC, Cain SW, Cohen DA, Frayling TM, Gooley JJ, Jones SE, Klerman EB, Lockley SW, Munch M, Rajaratnam SMW, Rueger M, Rutter MK, Santhi N, Scheuermaier K, Van Reen E, Weedon MN, Czeisler CA, Scheer FAJL, Saxena R. Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans. Sci Rep. 2019 03 29; 9(1):5350. PMID: 30926824.
    Citations: 5     Fields:    Translation:Humans
  19. Prayag AS, Münch M, Aeschbach D, Chellappa SL, Gronfier C. Light Modulation of Human Clocks, Wake, and Sleep. Clocks Sleep. 2019 Mar; 1(1):193-208. PMID: 32342043; PMCID: PMC7185269.
    Citations: 26     
  20. Quan SF, Lockyer BJ, Batool-Anwar S, Aeschbach D. Out of Center Sleep Testing in Ostensibly Healthy Middle Aged to Older Adults. Southwest J Pulm Crit Care. 2019; 18:87-93. PMID: 31123637; PMCID: PMC6528663.
  21. Zitting KM, Münch MY, Cain SW, Wang W, Wong A, Ronda JM, Aeschbach D, Czeisler CA, Duffy JF. Young adults are more vulnerable to chronic sleep deficiency and recurrent circadian disruption than older adults. Sci Rep. 2018 07 23; 8(1):11052. PMID: 30038272.
    Citations: 14     Fields:    Translation:Humans
  22. Elmenhorst EM, Elmenhorst D, Benderoth S, Kroll T, Bauer A, Aeschbach D. Cognitive impairments by alcohol and sleep deprivation indicate trait characteristics and a potential role for adenosine A1 receptors. Proc Natl Acad Sci U S A. 2018 07 31; 115(31):8009-8014. PMID: 30012607; PMCID: PMC6077699.
    Citations: 16     Fields:    Translation:Humans
  23. Djonlagic I, Aeschbach D, Harrison SL, Dean D, Yaffe K, Ancoli-Israel S, Stone K, Redline S. Associations between quantitative sleep EEG and subsequent cognitive decline in older women. J Sleep Res. 2019 06; 28(3):e12666. PMID: 29508460.
    Citations: 12     Fields:    Translation:Humans
  24. Mariani S, Tarokh L, Djonlagic I, Cade BE, Morrical MG, Yaffe K, Stone KL, Loparo KA, Purcell SM, Redline S, Aeschbach D. Evaluation of an automated pipeline for large-scale EEG spectral analysis: the National Sleep Research Resource. Sleep Med. 2018 07; 47:126-136. PMID: 29803181; PMCID: PMC5976521.
    Citations: 4     Fields:    Translation:Humans
  25. Hennecke E, Elmenhorst D, Mendolia F, Putzke M, Bauer A, Aeschbach D, Elmenhorst EM. Reestablishment of individual sleep structure during a single 14-h recovery sleep episode after 58 h of wakefulness. J Sleep Res. 2019 06; 28(3):e12641. PMID: 29171170.
    Citations: 1     Fields:    Translation:Humans
  26. Elmenhorst D, Elmenhorst EM, Hennecke E, Kroll T, Matusch A, Aeschbach D, Bauer A. Recovery sleep after extended wakefulness restores elevated A1 adenosine receptor availability in the human brain. Proc Natl Acad Sci U S A. 2017 04 18; 114(16):4243-4248. PMID: 28373571; PMCID: PMC5402442.
    Citations: 20     Fields:    Translation:Humans
  27. Chang AM, Bjonnes AC, Aeschbach D, Buxton OM, Gooley JJ, Anderson C, Van Reen E, Cain SW, Czeisler CA, Duffy JF, Lockley SW, Shea SA, Scheer FA, Saxena R. Circadian gene variants influence sleep and the sleep electroencephalogram in humans. Chronobiol Int. 2016; 33(5):561-73. PMID: 27089043; PMCID: PMC5267557.
    Citations: 4     Fields:    Translation:Humans
  28. Lane JM, Chang AM, Bjonnes AC, Aeschbach D, Anderson C, Cade BE, Cain SW, Czeisler CA, Gharib SA, Gooley JJ, Gottlieb DJ, Grant SF, Klerman EB, Lauderdale DS, Lockley SW, Munch M, Patel S, Punjabi NM, Rajaratnam SM, Rueger M, St Hilaire MA, Santhi N, Scheuermaier K, Van Reen E, Zee PC, Shea SA, Duffy JF, Buxton OM, Redline S, Scheer FA, Saxena R. Impact of Common Diabetes Risk Variant in MTNR1B on Sleep, Circadian, and Melatonin Physiology. Diabetes. 2016 06; 65(6):1741-51. PMID: 26868293; PMCID: PMC4878414.
    Citations: 33     Fields:    Translation:Humans
  29. Sanok S, Mendolia F, Wittkowski M, Rooney D, Putzke M, Aeschbach D. Passenger comfort on high-speed trains: effect of tunnel noise on the subjective assessment of pressure variations. Ergonomics. 2015; 58(6):1022-31. PMID: 25597694.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  30. Chang AM, Aeschbach D, Duffy JF, Czeisler CA. Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness. Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4):1232-7. PMID: 25535358; PMCID: PMC4313820.
    Citations: 265     Fields:    Translation:HumansCTClinical Trials
  31. Vejvoda M, Elmenhorst EM, Pennig S, Plath G, Maass H, Tritschler K, Basner M, Aeschbach D. Significance of time awake for predicting pilots' fatigue on short-haul flights: implications for flight duty time regulations. J Sleep Res. 2014 Oct; 23(5):564-7. PMID: 25040665.
    Citations: 6     Fields:    Translation:Humans
  32. Rahman SA, Flynn-Evans EE, Aeschbach D, Brainard GC, Czeisler CA, Lockley SW. Diurnal spectral sensitivity of the acute alerting effects of light. Sleep. 2014 Feb 01; 37(2):271-81. PMID: 24501435.
    Citations: 63     Fields:    Translation:Humans
  33. Chang AM, Scheer FA, Czeisler CA, Aeschbach D. Direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans depend on prior light history. Sleep. 2013 Aug 01; 36(8):1239-46. PMID: 23904684.
    Citations: 29     Fields:    Translation:Humans
  34. Morris CJ, Aeschbach D, Scheer FA. Circadian system, sleep and endocrinology. Mol Cell Endocrinol. 2012 Feb 05; 349(1):91-104. PMID: 21939733.
    Citations: 118     Fields:    Translation:HumansAnimals
  35. Grady S, Aeschbach D, Wright KP, Czeisler CA. Effect of modafinil on impairments in neurobehavioral performance and learning associated with extended wakefulness and circadian misalignment. Neuropsychopharmacology. 2010 Aug; 35(9):1910-20. PMID: 20505660.
    Citations: 15     Fields:    Translation:Humans
  36. Aeschbach D. Searching for function in deep sleep. Front Neurosci. 2009; 3(3):402-3.
  37. Aeschbach D. Slow waves and learning: beyond correlations. Sleep. 2009 Oct; 32(10):1253-4. PMID: 19848353.
    Citations: 4     Fields:    Translation:Humans
  38. Aeschbach D, Lockyer BJ, Dijk DJ, Lockley SW, Nuwayser ES, Nichols LD, Czeisler CA. Use of transdermal melatonin delivery to improve sleep maintenance during daytime. Clin Pharmacol Ther. 2009 Oct; 86(4):378-82. PMID: 19606092; PMCID: PMC2909186.
    Citations: 18     Fields:    Translation:Humans
  39. Santhi N, Aeschbach D, Horowitz TS, Czeisler CA. The impact of sleep timing and bright light exposure on attentional impairment during night work. J Biol Rhythms. 2008 Aug; 23(4):341-52. PMID: 18663241.
    Citations: 19     Fields:    Translation:Humans
  40. Aeschbach D, Cutler AJ, Ronda JM. A role for non-rapid-eye-movement sleep homeostasis in perceptual learning. J Neurosci. 2008 Mar 12; 28(11):2766-72. PMID: 18337406.
    Citations: 52     Fields:    Translation:Humans
  41. Zaidi FH, Hull JT, Peirson SN, Wulff K, Aeschbach D, Gooley JJ, Brainard GC, Gregory-Evans K, Rizzo JF, Czeisler CA, Foster RG, Moseley MJ, Lockley SW. Short-wavelength light sensitivity of circadian, pupillary, and visual awareness in humans lacking an outer retina. Curr Biol. 2007 Dec 18; 17(24):2122-8. PMID: 18082405.
    Citations: 109     Fields:    Translation:HumansCells
  42. Lockley SW, Evans EE, Scheer FA, Brainard GC, Czeisler CA, Aeschbach D. Short-wavelength sensitivity for the direct effects of light on alertness, vigilance, and the waking electroencephalogram in humans. Sleep. 2006 Feb; 29(2):161-8. PMID: 16494083.
    Citations: 166     Fields:    Translation:Humans
  43. Lockley SW, Cronin JW, Evans EE, Cade BE, Lee CJ, Landrigan CP, Rothschild JM, Katz JT, Lilly CM, Stone PH, Aeschbach D, Czeisler CA. Effect of reducing interns' weekly work hours on sleep and attentional failures. N Engl J Med. 2004 Oct 28; 351(18):1829-37. PMID: 15509816.
    Citations: 195     Fields:    Translation:Humans
  44. Allenspach K, Luckschander N, Styner M, Seibold F, Doherr M, Aeschbach D, Gaschen F. Evaluation of assays for perinuclear antineutrophilic cytoplasmic antibodies and antibodies to Saccharomyces cerevisiae in dogs with inflammatory bowel disease. Am J Vet Res. 2004 Sep; 65(9):1279-83. PMID: 15478778.
    Citations: 12     Fields:    Translation:Animals
  45. Aeschbach D, Sher L, Postolache TT, Matthews JR, Jackson MA, Wehr TA. A longer biological night in long sleepers than in short sleepers. J Clin Endocrinol Metab. 2003 Jan; 88(1):26-30. PMID: 12519823.
    Citations: 58     Fields:    Translation:Humans
  46. Wehr TA, Duncan WC, Sher L, Aeschbach D, Schwartz PJ, Turner EH, Postolache TT, Rosenthal NE. A circadian signal of change of season in patients with seasonal affective disorder. Arch Gen Psychiatry. 2001 Dec; 58(12):1108-14. PMID: 11735838.
    Citations: 73     Fields:    Translation:Humans
  47. Wehr TA, Aeschbach D, Duncan WC. Evidence for a biological dawn and dusk in the human circadian timing system. J Physiol. 2001 Sep 15; 535(Pt 3):937-51. PMID: 11559786; PMCID: PMC2278827.
    Citations: 36     Fields:    Translation:HumansCTClinical Trials
  48. Aeschbach D, Postolache TT, Sher L, Matthews JR, Jackson MA, Wehr TA. Evidence from the waking electroencephalogram that short sleepers live under higher homeostatic sleep pressure than long sleepers. Neuroscience. 2001; 102(3):493-502. PMID: 11226688.
    Citations: 26     Fields:    Translation:Humans
  49. Aeschbach D, Matthews JR, Postolache TT, Jackson MA, Giesen HA, Wehr TA. Two circadian rhythms in the human electroencephalogram during wakefulness. Am J Physiol. 1999 12; 277(6):R1771-9. PMID: 10600925.
    Citations: 46     Fields:    Translation:Humans
  50. Endo T, Roth C, Landolt HP, Werth E, Aeschbach D, Achermann P, Borbély AA. Effect of frequent brief awakenings from nonREM sleep on the nonREM-REM sleep cycle. Psychiatry Clin Neurosci. 1998 Apr; 52(2):129-30. PMID: 9628109.
    Citations:    Fields:    Translation:Humans
  51. Endo T, Roth C, Landolt HP, Werth E, Aeschbach D, Achermann P, Borbély AA. Selective REM sleep deprivation in humans: effects on sleep and sleep EEG. Am J Physiol. 1998 04; 274(4):R1186-94. PMID: 9575987.
    Citations: 30     Fields:    Translation:Humans
  52. Aeschbach D, Matthews JR, Postolache TT, Jackson MA, Giesen HA, Wehr TA. Dynamics of the human EEG during prolonged wakefulness: evidence for frequency-specific circadian and homeostatic influences. Neurosci Lett. 1997 Dec 19; 239(2-3):121-4. PMID: 9469671.
    Citations: 52     Fields:    Translation:Humans
  53. Aeschbach D, Dijk DJ, Borbély AA. Dynamics of EEG spindle frequency activity during extended sleep in humans: relationship to slow-wave activity and time of day. Brain Res. 1997 Feb 14; 748(1-2):131-6. PMID: 9067453.
    Citations: 18     Fields:    Translation:Humans
  54. Aeschbach D, Cajochen C, Landolt H, Borbély AA. Homeostatic sleep regulation in habitual short sleepers and long sleepers. Am J Physiol. 1996 Jan; 270(1 Pt 2):R41-53. PMID: 8769783.
    Citations: 49     Fields:    Translation:Humans
  55. Aeschbach D, Dijk DJ, Trachsel L, Brunner DP, Borbély AA. Dynamics of slow-wave activity and spindle frequency activity in the human sleep EEG: effect of midazolam and zopiclone. Neuropsychopharmacology. 1994 Dec; 11(4):237-44. PMID: 7857498.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  56. Cajochen C, Pischke J, Aeschbach D, Borbély AA. Heart rate dynamics during human sleep. Physiol Behav. 1994 Apr; 55(4):769-74. PMID: 8190808.
    Citations: 20     Fields:    Translation:Humans
  57. Aeschbach D, Cajochen C, Tobler I, Dijk DJ, Borbély AA. Sleep in a sitting position: effect of triazolam on sleep stages and EEG power spectra. Psychopharmacology (Berl). 1994 Mar; 114(2):209-14. PMID: 7838909.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  58. Aeschbach D, Borbély AA. All-night dynamics of the human sleep EEG. J Sleep Res. 1993 Jun; 2(2):70-81. PMID: 10607074.
    Citations: 64     Fields:    
  59. Dijk DJ, Brunner DP, Aeschbach D, Tobler I, Borbély AA. The effects of ethanol on human sleep EEG power spectra differ from those of benzodiazepine receptor agonists. Neuropsychopharmacology. 1992 Nov; 7(3):225-32. PMID: 1326982.
    Citations: 17     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.