Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

John Wen-Yueh Chen, M.D., Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS103998 (CHEN, JOHN W) May 15, 2018 - Feb 28, 2023
    Imaging macrophage and microglial functional diversity in stroke
    Role: Principal Investigator
  2. R01NS072167 (CHEN, JOHN W) Sep 1, 2010 - Oct 31, 2015
    Imaging and Treating Inflammation in Stroke by Targeting Myeloperoxidase
    Role: Principal Investigator
  3. R01NS070835 (CHEN, JOHN W) Jul 1, 2010 - Jun 30, 2015
    Myeloperoxidase, imaging biomarker and treatment target for multiple sclerosis
    Role: Principal Investigator
  4. K08HL081170 (CHEN, JOHN W) Sep 1, 2006 - Jun 30, 2011
    Molecular imaging of vascular pathology
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ali M, Fulci G, Grigalavicius M, Pulli B, Li A, Wojtkiewicz GR, Wang C, Hsieh KL, Linnoila JJ, Theodossiou TA, Chen JW. Myeloperoxidase exerts anti-tumor activity in glioma after radiotherapy. Neoplasia. 2022 04; 26:100779. PMID: 35247801.
    Citations:    Fields:    
  2. Li JH, Forghani R, Bure L, Wojtkiewicz GR, Wu Y, Iwamoto Y, Ali M, Li A, Wang C, Jalali Motlagh N, Papadakis AI, Pusztaszeri MP, Spatz A, Curtin H, Cheng YS, Chen JW. Molecular immuno-imaging improves tumor detection in head and neck cancer. FASEB J. 2022 01; 36(1):e22092. PMID: 34919761.
    Citations:    Fields:    Translation:AnimalsCells
  3. Jalali Motlagh N, Wang C, Kuellenberg EG, Wojtkiewicz GR, Schmidt S, Chen JW. D-Mannose Slows Glioma Growth by Modulating Myeloperoxidase Activity. Cancers (Basel). 2021 Dec 18; 13(24). PMID: 34944979.
  4. Wang J, Jalali Motlagh N, Wang C, Wojtkiewicz GR, Schmidt S, Chau C, Narsimhan R, Kullenberg EG, Zhu C, Linnoila J, Yao Z, Chen JW. d-mannose suppresses oxidative response and blocks phagocytosis in experimental neuroinflammation. Proc Natl Acad Sci U S A. 2021 11 02; 118(44). PMID: 34702739.
    Citations: 1     Fields:    Translation:Animals
  5. Chen JW. Does Brain Gadolinium Deposition Have Clinical Consequence? Lessons from Animal Studies. Radiology. 2021 Nov; 301(2):E417. PMID: 34694937.
    Citations:    Fields:    
  6. Chen JW. Does Brain Gadolinium Deposition Have Clinical Consequence? Lessons from Animal Studies. Radiology. 2021 11; 301(2):417-419. PMID: 34463556.
    Citations:    Fields:    Translation:Animals
  7. Wang C, Cheng D, Jalali Motlagh N, Kuellenberg EG, Wojtkiewicz GR, Schmidt SP, Stocker R, Chen JW. Highly Efficient Activatable MRI Probe to Sense Myeloperoxidase Activity. J Med Chem. 2021 05 13; 64(9):5874-5885. PMID: 33945286.
    Citations:    Fields:    Translation:AnimalsCells
  8. Badr CE, da Hora CC, Kirov AB, Tabet E, Amante R, Maksoud S, Nibbs AE, Fitzsimons E, Boukhali M, Chen JW, Chiu NHL, Nakano I, Haas W, Mazitschek R, Tannous BA. Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation. ACS Chem Biol. 2020 06 19; 15(6):1445-1454. PMID: 32338864.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  9. Barreto SG, Brooke-Smith ME, Neo EL, Dolan P, Leibbrandt R, Emery T, Carroll R, Wigg A, Chen JW. Exploring pre-surgery donor-specific antibodies in the context of organ shortage in liver transplant. Langenbecks Arch Surg. 2019 Nov; 404(7):865-874. PMID: 31748871.
    Citations:    Fields:    Translation:HumansCells
  10. Wang C, Pulli B, Jalali Motlagh N, Li A, Wojtkiewicz GR, Schmidt SP, Wu Y, Zeller MWG, Chen JW. A versatile imaging platform with fluorescence and CT imaging capabilities that detects myeloperoxidase activity and inflammation at different scales. Theranostics. 2019; 9(25):7525-7536. PMID: 31695784.
    Citations: 4     Fields:    Translation:AnimalsCells
  11. Li A, Wu Y, Pulli B, Wojtkiewicz GR, Iwamoto Y, Wang C, Li JH, Ali M, Feng X, Yao Z, Chen JW. Myeloperoxidase Molecular MRI Reveals Synergistic Combination Therapy in Murine Experimental Autoimmune Neuroinflammation. Radiology. 2019 10; 293(1):158-165. PMID: 31478802.
    Citations: 1     Fields:    Translation:Animals
  12. Wang C, Keliher E, Zeller MWG, Wojtkiewicz GR, Aguirre AD, Buckbinder L, Kim HY, Chen J, Maresca K, Ahmed MS, Motlagh NJ, Nahrendorf M, Chen JW. An activatable PET imaging radioprobe is a dynamic reporter of myeloperoxidase activity in vivo. Proc Natl Acad Sci U S A. 2019 06 11; 116(24):11966-11971. PMID: 31123149.
    Citations: 9     Fields:    Translation:HumansAnimals
  13. Chen J, Landegger LD, Sun Y, Ren J, Maimon N, Wu L, Ng MR, Chen JW, Zhang N, Zhao Y, Gao X, Fujita T, Roberge S, Huang P, Jain RK, Plotkin SR, Stankovic KM, Xu L. A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma. Nat Protoc. 2019 02; 14(2):541-555. PMID: 30617350.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  14. Hoffmann A, Pfeil J, Mueller AK, Jin J, Deumelandt K, Helluy X, Wang C, Heiland S, Platten M, Chen JW, Bendszus M, Breckwoldt MO. MRI of Iron Oxide Nanoparticles and Myeloperoxidase Activity Links Inflammation to Brain Edema in Experimental Cerebral Malaria. Radiology. 2019 02; 290(2):359-367. PMID: 30615566.
    Citations: 2     Fields:    Translation:Animals
  15. Choi SH, Bylykbashi E, Chatila ZK, Lee SW, Pulli B, Clemenson GD, Kim E, Rompala A, Oram MK, Asselin C, Aronson J, Zhang C, Miller SJ, Lesinski A, Chen JW, Kim DY, van Praag H, Spiegelman BM, Gage FH, Tanzi RE. Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model. Science. 2018 09 07; 361(6406). PMID: 30190379.
    Citations: 151     Fields:    Translation:HumansAnimals
  16. Zhang Y, Dong H, Seeburg DP, Wojtkiewicz GR, Waterman P, Pulli B, Forghani R, Ali M, Iwamoto Y, Swirski FK, Chen JW. Multimodal Molecular Imaging Demonstrates Myeloperoxidase Regulation of Matrix Metalloproteinase Activity in Neuroinflammation. Mol Neurobiol. 2019 Feb; 56(2):954-962. PMID: 29808380.
    Citations: 5     Fields:    Translation:Animals
  17. Kim HJ, Wei Y, Wojtkiewicz GR, Lee JY, Moskowitz MA, Chen JW. Reducing myeloperoxidase activity decreases inflammation and increases cellular protection in ischemic stroke. J Cereb Blood Flow Metab. 2019 09; 39(9):1864-1877. PMID: 29673284.
    Citations: 8     Fields:    Translation:Animals
  18. Shen S, Ding W, Ahmed S, Hu R, Opalacz A, Roth S, You Z, Wotjkiewicz GR, Lim G, Chen L, Mao J, Chen JW, Zhang Y. Ultrasmall Superparamagnetic Iron Oxide Imaging Identifies Tissue and Nerve Inflammation in Pain Conditions. Pain Med. 2018 04 01; 19(4):686-692. PMID: 29177411.
    Citations: 1     Fields:    Translation:HumansAnimals
  19. Hwang I, Oh H, Santo E, Kim DY, Chen JW, Bronson RT, Locasale JW, Na Y, Lee J, Reed S, Toth M, Yu WH, Muller FL, Paik J. FOXO protects against age-progressive axonal degeneration. Aging Cell. 2018 02; 17(1). PMID: 29178390.
    Citations: 18     Fields:    Translation:AnimalsCells
  20. Walsh RM, Shen EY, Bagot RC, Anselmo A, Jiang Y, Javidfar B, Wojtkiewicz GJ, Cloutier J, Chen JW, Sadreyev R, Nestler EJ, Akbarian S, Hochedlinger K. Phf8 loss confers resistance to depression-like and anxiety-like behaviors in mice. Nat Commun. 2017 05 09; 8:15142. PMID: 28485378.
    Citations: 11     Fields:    Translation:AnimalsCells
  21. Pulli B, Wojtkiewicz G, Iwamoto Y, Ali M, Zeller MW, Bure L, Wang C, Choi Y, Masia R, Guimaraes AR, Corey KE, Chen JW. Molecular MR Imaging of Myeloperoxidase Distinguishes Steatosis from Steatohepatitis in Nonalcoholic Fatty Liver Disease. Radiology. 2017 08; 284(2):390-400. PMID: 28358240.
    Citations: 11     Fields:    Translation:HumansAnimals
  22. Geyer MC, Coates PT, Khurana S, Chen JW, Kay TW, Balamurugan AN, Couper JJ, Radford T, Drogemuller CJ, Loudovaris T, Pathi R, Wilks MJ, Couper RT. First Report of Successful Total Pancreatectomy and Islet Autotransplant in Australia. Pancreas. 2017 03; 46(3):e18-e20. PMID: 28187110.
    Citations: 1     Fields:    Translation:Humans
  23. Zhang Y, Seeburg DP, Pulli B, Wojtkiewicz GR, Bure L, Atkinson W, Schob S, Iwamoto Y, Ali M, Zhang W, Rodriguez E, Milewski A, Keliher EJ, Wang C, Pan Y, Swirski FK, Chen JW. Myeloperoxidase Nuclear Imaging for Epileptogenesis. Radiology. 2017 02; 282(2):614. PMID: 28099101.
    Citations:    Fields:    
  24. Keliher EJ, Ye YX, Wojtkiewicz GR, Aguirre AD, Tricot B, Senders ML, Groenen H, Fay F, Perez-Medina C, Calcagno C, Carlucci G, Reiner T, Sun Y, Courties G, Iwamoto Y, Kim HY, Wang C, Chen JW, Swirski FK, Wey HY, Hooker J, Fayad ZA, Mulder WJ, Weissleder R, Nahrendorf M. Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease. Nat Commun. 2017 01 16; 8:14064. PMID: 28091604.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  25. Ali M, Pulli B, Courties G, Tricot B, Sebas M, Iwamoto Y, Hilgendorf I, Schob S, Dong A, Zheng W, Skoura A, Kalgukar A, Cortes C, Ruggeri R, Swirski FK, Nahrendorf M, Buckbinder L, Chen JW. Myeloperoxidase Inhibition Improves Ventricular Function and Remodeling After Experimental Myocardial Infarction. JACC Basic Transl Sci. 2016 Dec; 1(7):633-643. PMID: 30167547.
    Citations: 32     
  26. Kirschbaum K, Sonner JK, Zeller MW, Deumelandt K, Bode J, Sharma R, Krüwel T, Fischer M, Hoffmann A, Costa da Silva M, Muckenthaler MU, Wick W, Tews B, Chen JW, Heiland S, Bendszus M, Platten M, Breckwoldt MO. In vivo nanoparticle imaging of innate immune cells can serve as a marker of disease severity in a model of multiple sclerosis. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13227-13232. PMID: 27799546.
    Citations: 40     Fields:    Translation:AnimalsCells
  27. Li A, Wu Y, Linnoila J, Pulli B, Wang C, Zeller M, Ali M, Lewandrowski GK, Li J, Tricot B, Keliher E, Wojtkiewicz GR, Fulci G, Feng X, Tannous BA, Yao Z, Chen JW. Surface biotinylation of cytotoxic T lymphocytes for in vivo tracking of tumor immunotherapy in murine models. Cancer Immunol Immunother. 2016 12; 65(12):1545-1554. PMID: 27722909.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  28. Kim H, Wei Y, Lee JY, Wu Y, Zheng Y, Moskowitz MA, Chen JW. Myeloperoxidase Inhibition Increases Neurogenesis after Ischemic Stroke. J Pharmacol Exp Ther. 2016 Nov; 359(2):262-272. PMID: 27550713.
    Citations: 17     Fields:    Translation:AnimalsCells
  29. Albadawi H, Chen JW, Oklu R, Wu Y, Wojtkiewicz G, Pulli B, Milner JD, Cambria RP, Watkins MT. Spinal Cord Inflammation: Molecular Imaging after Thoracic Aortic Ischemia Reperfusion Injury. Radiology. 2017 Jan; 282(1):202-211. PMID: 27509542.
    Citations: 5     Fields:    Translation:Animals
  30. Chandrasegaram MD, Chen JW, Price TJ, Zalcberg J, Sjoquist K, Merrett ND. Advances in Molecular Pathology and Treatment of Periampullary Cancers. Pancreas. 2016 Jan; 45(1):32-9. PMID: 26348463.
    Citations: 8     Fields:    Translation:HumansAnimals
  31. Liang JS, Lee SP, Pulli B, Chen JW, Kao SC, Tsang YM, Hsieh KL. Microstructural Changes in Absence Seizure Children: A Diffusion Tensor Magnetic Resonance Imaging Study. Pediatr Neonatol. 2016 08; 57(4):318-25. PMID: 26750405.
    Citations: 4     Fields:    Translation:Humans
  32. Kuijten MM, Hannah Degeling M, Chen JW, Wojtkiewicz G, Waterman P, Weissleder R, Azzi J, Nicolay K, Tannous BA. Multimodal targeted high relaxivity thermosensitive liposome for in vivo imaging. Sci Rep. 2015 Nov 27; 5:17220. PMID: 26610702.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  33. Tong T, Yang Z, Chen JW, Zhu J, Yao Z. Dynamic 1H-MRS assessment of brain tumors: a novel approach for differential diagnosis of glioma. Oncotarget. 2015 Oct 13; 6(31):32257-65. PMID: 26337080.
    Citations: 1     Fields:    Translation:Humans
  34. Zhang Y, Seeburg DP, Pulli B, Wojtkiewicz GR, Bure L, Atkinson W, Schob S, Iwamoto Y, Ali M, Zhang W, Rodriguez E, Milewski A, Keliher EJ, Wang C, Pan Y, Swirski FK, Chen JW. Myeloperoxidase Nuclear Imaging for Epileptogenesis. Radiology. 2016 Mar; 278(3):822-30. PMID: 26397127.
    Citations: 9     Fields:    Translation:Animals
  35. Li-ChunHsieh K, Schob S, Zeller MW, Pulli B, Ali M, Wang C, Chiou TT, Tsang YM, Lee PS, Stossel TP, Chen JW. Gelsolin decreases actin toxicity and inflammation in murine multiple sclerosis. J Neuroimmunol. 2015 Oct 15; 287:36-42. PMID: 26439960.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  36. Pulli B, Ali M, Iwamoto Y, Zeller MW, Schob S, Linnoila JJ, Chen JW. Myeloperoxidase-Hepatocyte-Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis. Antioxid Redox Signal. 2015 Dec 01; 23(16):1255-69. PMID: 26058518.
    Citations: 32     Fields:    Translation:AnimalsCells
  37. Forghani R, Kim HJ, Wojtkiewicz GR, Bure L, Wu Y, Hayase M, Wei Y, Zheng Y, Moskowitz MA, Chen JW. Myeloperoxidase propagates damage and is a potential therapeutic target for subacute stroke. J Cereb Blood Flow Metab. 2015 Mar; 35(3):485-93. PMID: 25515211.
    Citations: 20     Fields:    Translation:Animals
  38. Pulli B, Bure L, Wojtkiewicz GR, Iwamoto Y, Ali M, Li D, Schob S, Hsieh KL, Jacobs AH, Chen JW. Multiple sclerosis: myeloperoxidase immunoradiology improves detection of acute and chronic disease in experimental model. Radiology. 2015 May; 275(2):480-9. PMID: 25494298.
    Citations: 16     Fields:    Translation:Animals
  39. Lartey FM, Ahn GO, Ali R, Rosenblum S, Miao Z, Arksey N, Shen B, Colomer MV, Rafat M, Liu H, Alejandre-Alcazar MA, Chen JW, Palmer T, Chin FT, Guzman R, Loo BW, Graves E. The relationship between serial [(18)?F]PBR06 PET imaging of microglial activation and motor function following stroke in mice. Mol Imaging Biol. 2014 Dec; 16(6):821-9. PMID: 24865401.
    Citations: 11     Fields:    Translation:AnimalsCells
  40. Mehan WA, González RG, Buchbinder BR, Chen JW, Copen WA, Gupta R, Hirsch JA, Hunter GJ, Hunter S, Johnson JM, Kelly HR, Larvie M, Lev MH, Pomerantz SR, Rapalino O, Rincon S, Romero JM, Schaefer PW, Shah V. Optimal brain MRI protocol for new neurological complaint. PLoS One. 2014; 9(10):e110803. PMID: 25343371.
    Citations: 4     Fields:    Translation:Humans
  41. Weber GF, Chousterman BG, Hilgendorf I, Robbins CS, Theurl I, Gerhardt LM, Iwamoto Y, Quach TD, Ali M, Chen JW, Rothstein TL, Nahrendorf M, Weissleder R, Swirski FK. Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis. J Exp Med. 2014 Jun 02; 211(6):1243-56. PMID: 24821911.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  42. Katsimpardi L, Litterman NK, Schein PA, Miller CM, Loffredo FS, Wojtkiewicz GR, Chen JW, Lee RT, Wagers AJ, Rubin LL. Vascular and neurogenic rejuvenation of the aging mouse brain by young systemic factors. Science. 2014 May 09; 344(6184):630-4. PMID: 24797482.
    Citations: 380     Fields:    Translation:AnimalsCells
  43. Ali M, Pulli B, Chen JW. Molecular imaging of macrophage enzyme activity in cardiac inflammation. Curr Cardiovasc Imaging Rep. 2014 Apr 01; 7(4):9258. PMID: 24729833.
    Citations: 4     
  44. Hsieh LC, Chen JW, Wang LY, Tsang YM, Shueng PW, Liao LJ, Lo WC, Lin YC, Tseng CF, Kuo YS, Jhuang JY, Tien HJ, Juan HF, Hsieh CH. Predicting the severity and prognosis of trismus after intensity-modulated radiation therapy for oral cancer patients by magnetic resonance imaging. PLoS One. 2014; 9(3):e92561. PMID: 24658376.
    Citations: 11     Fields:    Translation:HumansPHPublic Health
  45. Lai CP, Mardini O, Ericsson M, Prabhakar S, Maguire C, Chen JW, Tannous BA, Breakefield XO. Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter. ACS Nano. 2014 Jan 28; 8(1):483-494. PMID: 24383518.
    Citations: 260     Fields:    Translation:HumansAnimalsCells
  46. Pulli B, Chen JW. Imaging Neuroinflammation - from Bench to Bedside. J Clin Cell Immunol. 2014; 5. PMID: 25525560.
    Citations: 14     
  47. Verran DJ, Mulhearn MH, Dilworth PJ, Balderson GA, Munn S, Chen JW, Fink MA, Crawford MD, McCaughan GW. Nature and outcomes of the increased incidence of colorectal malignancy after liver transplantation in Australasia. Med J Aust. 2013 Nov 04; 199(9):610-2. PMID: 24182227.
    Citations: 5     Fields:    Translation:Humans
  48. Oklu R, Deipolyi AR, Wicky S, Ergul E, Deik AA, Chen JW, Hirsch JA, Wojtkiewicz GR, Clish CB. Identification of small compound biomarkers of pituitary adenoma: a bilateral inferior petrosal sinus sampling study. J Neurointerv Surg. 2014 Sep; 6(7):541-6. PMID: 24005126.
    Citations: 6     Fields:    Translation:Humans
  49. Lartey FM, Ahn GO, Shen B, Cord KT, Smith T, Chua JY, Rosenblum S, Liu H, James ML, Chernikova S, Lee SW, Pisani LJ, Tirouvanziam R, Chen JW, Palmer TD, Chin FT, Guzman R, Graves EE, Loo BW. PET imaging of stroke-induced neuroinflammation in mice using [18F]PBR06. Mol Imaging Biol. 2014 Feb; 16(1):109-17. PMID: 23836504.
    Citations: 23     Fields:    Translation:Animals
  50. Pulli B, Ali M, Forghani R, Schob S, Hsieh KL, Wojtkiewicz G, Linnoila JJ, Chen JW. Measuring myeloperoxidase activity in biological samples. PLoS One. 2013; 8(7):e67976. PMID: 23861842.
    Citations: 111     Fields:    Translation:AnimalsCells
  51. Prabhakar S, Goto J, Zhang X, Zuang X, Sena-Esteves M, Bronson R, Brockmann J, Gianni D, Wojtkiewicz GR, Chen JW, Stemmer-Rachamimov A, Kwiatkowski DJ, Breakefield XO. Stochastic model of Tsc1 lesions in mouse brain. PLoS One. 2013; 8(5):e64224. PMID: 23696872.
    Citations: 10     Fields:    Translation:Animals
  52. Majmudar MD, Keliher EJ, Heidt T, Leuschner F, Truelove J, Sena BF, Gorbatov R, Iwamoto Y, Dutta P, Wojtkiewicz G, Courties G, Sebas M, Borodovsky A, Fitzgerald K, Nolte MW, Dickneite G, Chen JW, Anderson DG, Swirski FK, Weissleder R, Nahrendorf M. Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice. Circulation. 2013 May 21; 127(20):2038-46. PMID: 23616627.
    Citations: 121     Fields:    Translation:AnimalsCells
  53. González RG, Copen WA, Schaefer PW, Lev MH, Pomerantz SR, Rapalino O, Chen JW, Hunter GJ, Romero JM, Buchbinder BR, Larvie M, Hirsch JA, Gupta R. The Massachusetts General Hospital acute stroke imaging algorithm: an experience and evidence based approach. J Neurointerv Surg. 2013 May; 5 Suppl 1:i7-12. PMID: 23493340.
    Citations: 23     Fields:    Translation:Humans
  54. Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ. Angiotensin II drives the production of tumor-promoting macrophages. Immunity. 2013 Feb 21; 38(2):296-308. PMID: 23333075.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  55. Chen JW, Figueiredo JL, Wojtkiewicz GR, Siegel C, Iwamoto Y, Kim DE, Nolte MW, Dickneite G, Weissleder R, Nahrendorf M. Selective factor XIIa inhibition attenuates silent brain ischemia: application of molecular imaging targeting coagulation pathway. JACC Cardiovasc Imaging. 2012 Nov; 5(11):1127-38. PMID: 23153913.
    Citations: 8     Fields:    Translation:Animals
  56. Forghani R, Wojtkiewicz GR, Zhang Y, Seeburg D, Bautz BR, Pulli B, Milewski AR, Atkinson WL, Iwamoto Y, Zhang ER, Etzrodt M, Rodriguez E, Robbins CS, Swirski FK, Weissleder R, Chen JW. Demyelinating diseases: myeloperoxidase as an imaging biomarker and therapeutic target. Radiology. 2012 May; 263(2):451-60. PMID: 22438365.
    Citations: 43     Fields:    Translation:Animals
  57. Atkinson W, Forghani R, Wojtkiewicz GR, Pulli B, Iwamoto Y, Ueno T, Waterman P, Truelove J, Oklu R, Chen JW. Ligation of the jugular veins does not result in brain inflammation or demyelination in mice. PLoS One. 2012; 7(3):e33671. PMID: 22457780.
    Citations: 6     Fields:    Translation:Animals
  58. Niers JM, Chen JW, Lewandrowski G, Kerami M, Garanger E, Wojtkiewicz G, Waterman P, Keliher E, Weissleder R, Tannous BA. Single reporter for targeted multimodal in vivo imaging. J Am Chem Soc. 2012 Mar 21; 134(11):5149-56. PMID: 22397453.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  59. Cortez-Retamozo V, Etzrodt M, Newton A, Rauch PJ, Chudnovskiy A, Berger C, Ryan RJ, Iwamoto Y, Marinelli B, Gorbatov R, Forghani R, Novobrantseva TI, Koteliansky V, Figueiredo JL, Chen JW, Anderson DG, Nahrendorf M, Swirski FK, Weissleder R, Pittet MJ. Origins of tumor-associated macrophages and neutrophils. Proc Natl Acad Sci U S A. 2012 Feb 14; 109(7):2491-6. PMID: 22308361.
    Citations: 258     Fields:    Translation:HumansAnimalsCells
  60. Su HS, Nahrendorf M, Panizzi P, Breckwoldt MO, Rodriguez E, Iwamoto Y, Aikawa E, Weissleder R, Chen JW. Vasculitis: molecular imaging by targeting the inflammatory enzyme myeloperoxidase. Radiology. 2012 Jan; 262(1):181-90. PMID: 22084204.
    Citations: 12     Fields:    Translation:Animals
  61. Zhang W, Fulci G, Buhrman JS, Stemmer-Rachamimov AO, Chen JW, Wojtkiewicz GR, Weissleder R, Rabkin SD, Martuza RL. Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma. Mol Ther. 2012 Jan; 20(1):37-45. PMID: 21915104.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  62. Kleijn A, Chen JW, Buhrman JS, Wojtkiewicz GR, Iwamoto Y, Lamfers ML, Stemmer-Rachamimov AO, Rabkin SD, Weissleder R, Martuza RL, Fulci G. Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging. Clin Cancer Res. 2011 Jul 01; 17(13):4484-93. PMID: 21558403.
    Citations: 19     Fields:    Translation:AnimalsCells
  63. Niers JM, Chen JW, Weissleder R, Tannous BA. Enhanced in vivo imaging of metabolically biotinylated cell surface reporters. Anal Chem. 2011 Feb 01; 83(3):994-9. PMID: 21214190.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  64. Swirski FK, Wildgruber M, Ueno T, Figueiredo JL, Panizzi P, Iwamoto Y, Zhang E, Stone JR, Rodriguez E, Chen JW, Pittet MJ, Weissleder R, Nahrendorf M. Myeloperoxidase-rich Ly-6C+ myeloid cells infiltrate allografts and contribute to an imaging signature of organ rejection in mice. J Clin Invest. 2010 Jul; 120(7):2627-34. PMID: 20577051.
    Citations: 50     Fields:    Translation:AnimalsCells
  65. Chen JW, Bhandari M, Astill DS, Wilson TG, Kow L, Brooke-Smith M, Toouli J, Padbury RT. Predicting patient survival after pancreaticoduodenectomy for malignancy: histopathological criteria based on perineural infiltration and lymphovascular invasion. HPB (Oxford). 2010 Mar; 12(2):101-8. PMID: 20495653.
    Citations: 38     Fields:    Translation:Humans
  66. Rodríguez E, Nilges M, Weissleder R, Chen JW. Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity. J Am Chem Soc. 2010 Jan 13; 132(1):168-77. PMID: 19968300.
    Citations: 44     Fields:    Translation:AnimalsCells
  67. Ronald JA, Chen JW, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK. Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques. Circulation. 2009 Aug 18; 120(7):592-9. PMID: 19652086.
    Citations: 57     Fields:    Translation:AnimalsCells
  68. Rajendran R, Ronald JA, Ye T, Minqin R, Chen JW, Weissleder R, Rutt BK, Halliwell B, Watt F. Nuclear microscopy: a novel technique for quantitative imaging of gadolinium distribution within tissue sections. Microsc Microanal. 2009 Aug; 15(4):338-44. PMID: 19575834.
    Citations:    Fields:    Translation:Animals
  69. Zhu H, Acquaviva J, Ramachandran P, Boskovitz A, Woolfenden S, Pfannl R, Bronson RT, Chen JW, Weissleder R, Housman DE, Charest A. Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis. Proc Natl Acad Sci U S A. 2009 Feb 24; 106(8):2712-6. PMID: 19196966.
    Citations: 107     Fields:    Translation:HumansAnimalsCells
  70. McCann CM, Waterman P, Figueiredo JL, Aikawa E, Weissleder R, Chen JW. Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy. Neuroimage. 2009 Apr 01; 45(2):360-9. PMID: 19154791.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  71. Brass SD, Durand ML, Stone JH, Chen JW, Stone JR. Case records of the Massachusetts General Hospital. Case 36-2008. A 59-year-old man with chronic daily headache. N Engl J Med. 2008 Nov 20; 359(21):2267-78. PMID: 19020329.
    Citations: 4     Fields:    Translation:Humans
  72. Breckwoldt MO, Chen JW, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, Moskowitz MA, Weissleder R. Tracking the inflammatory response in stroke in vivo by sensing the enzyme myeloperoxidase. Proc Natl Acad Sci U S A. 2008 Nov 25; 105(47):18584-9. PMID: 19011099.
    Citations: 130     Fields:    Translation:Animals
  73. Elisenda Rodriguez, John W. Chen. MR Imaging Agents. Molecular Imaging: Principles and Practice. 2008; in press.
  74. Elisenda Rodriguez, Ralph Weissleder, John W. Chen. MR sensors of myeloperoxidase activity. Characterization and mechanism of activation. Proceedings of the Gordon Research Conference on in vivo Magnetic Resonance. 2008.
  75. Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R. Myeloperoxidase-targeted imaging of active inflammatory lesions in multiple sclerosis. Brain. 2008; 131(4):1123-1133.
  76. Nahrendorf M, Sosnovik D, Chen JW, Panizzi P, Figueiredo J-L, Aikawa E, Libby P, Swirksi F, Weissleder R. An activatable MR imaging agent follows myeloperoxidase activity in healing infarcts and detects atorvastatin-mediated attenuation of ischemia reperfusion injury non-invasively. Circulation. 2008; 117(9):1153-1160.
  77. Nahrendorf M, Sosnovik D, Chen JW, Panizzi P, Figueiredo JL, Aikawa E, Libby P, Swirski FK, Weissleder R. Activatable magnetic resonance imaging agent reports myeloperoxidase activity in healing infarcts and noninvasively detects the antiinflammatory effects of atorvastatin on ischemia-reperfusion injury. Circulation. 2008 Mar 04; 117(9):1153-60. PMID: 18268141.
    Citations: 81     Fields:    Translation:Animals
  78. Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R. Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis. Brain. 2008 Apr; 131(Pt 4):1123-33. PMID: 18234693.
    Citations: 56     Fields:    Translation:AnimalsCells
  79. Elisenda Rodriguez, John W. Chen. Molecular Imaging - Basic Approaches. Imaging in CNS Drug Development: Implications for Disease and Therapy. 2008; in press.
  80. Henry S. Su, John W. Chen, Michael O. Breckwoldt, Elena Aikawa, Matthias Nahrendorf, Ralph Weissleder. Noninvasive in vivo imaging confirmation of vasculitis by targeting the inflammatory enzyme myeloperoxidase. Proceedings of the Radiological Society of North America. 2007; SSK04-04 (abstract).
  81. John W. Chen, Michael O. Breckwoldt, Elena Aikawa, Gloria Chiang Ralph Weissleder. Myeloperoxidase-targeted imaging improves active inflammatory lesion detection in demyelinating diseases. Proceedings of the Radiological Society of North America. 2007; SSC05-06 (abstract).
  82. Henry S. Su, John W. Chen, Michael O. Breckwoldt, Elena Aikawa, Matthias Nahrendorf, Ralph Weissleder. MR Imaging of Myeloperoxidase in Murine Vasculitis. Proceedings of the Joint Molecular Imaging Conference. 2007; 76 (abstract).
  83. John A. Ronald/John W. Chen, Kem A. Rogers, Robert A. Hegele1, Manel Querol, Alexei Bogdanov, Brian K. Rutt, Ralph Weissleder. In Vivo Identification of "Active" Inflammation in Experimental Atherosclerosis Via Myeloperoxidase MR Imaging. Proceedings of Joint Molecular Imaging Conference. 2007; 57 (abstract).
  84. Bogdanov AA, Querol M, Chen JW. [Visualization of the enzymatic activity in living systems using activated NMR contrast agents]. Biofizika. 2007 May-Jun; 52(3):389-400. PMID: 17633527.
    Citations: 1     Fields:    Translation:HumansAnimals
  85. J. Ronald/J. Chen, K. Rogers, R. Hegele1, M. Querol, A. Bogdanov R. Weissleder, and B. Rutt. Molecular MRI of Myeloperoxidase Activity in Experimental Atherosclerosis using a Novel Paramagnetic “Smart” Contrast Agent. International Society of Magnetic Resonance in Medicine. 2007.
  86. Michael Oliver Breckwoldt, John W. Chen, Lars Stangenberg, Elena Aikawa, Jose Luiz Figueiredo, Shumei Qiu, Michael Moskowitz, Ralph Weissleder. Myeloperoxidase Imaging in a Mouse Model of Stroke. Joint Molecular Imaging Conference. 2007.
  87. Corey M McCann, Peter Waterman, Jose L Figueiredo, John W Chen. Accuracy of combined MR-FMT imaging in the brain of living mice. Joint Molecular Imaging Conference. 2007.
  88. Chen JW, Chiang, G, Aikawa E, Weissleder R. Imaging active demyelinating plaques by targeting myeloperoxidase. Proceedings of the Radiological Society of North America. 2006; SSC05-01 (abstract).
  89. Ralph Weissleder, Jack Wittenberg, Mukesh G. Harisinghani, John W. Chen. Primer of Diagnostic Imaging. 2006.
  90. Chen JW, Querol Sans M, Bogdanov A, Weissleder R. Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates. Radiology. 2006 Aug; 240(2):473-81. PMID: 16864673.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  91. Tannous BA, Grimm J, Perry KF, Chen JW, Weissleder R, Breakefield XO. Metabolic biotinylation of cell surface receptors for in vivo imaging. Nat Methods. 2006 May; 3(5):391-6. PMID: 16628210.
    Citations: 48     Fields:    Translation:HumansCells
  92. Querol M, Chen JW, Bogdanov AA. A paramagnetic contrast agent with myeloperoxidase-sensing properties. Org Biomol Chem. 2006 May 21; 4(10):1887-95. PMID: 16688334.
    Citations: 26     Fields:    
  93. Alexei Bogdanov, John W. Chen, Ralph Weissleder, Manel Querol. Imaging of enzyme activity. 2006.
  94. J. Ronald, J.W. Chen, K. Rogers, M. Querol, A. Bogdanov, B. Rutt, R. Weissleder. Molecular imaging of myeloperoxidase activity in rabbit atherosclerotic plaques. Society for Molecular Imaging. 2006.
  95. Chen JW, Querol Sans M, Bogdanov A, Weissleder R. Toward moelcular imaging of vulnerable plaques: in vivo validation of MR and scintigraphic contrast agents targeting myeloperoxidase. Proceedings of the Radiological Society of North America. 2005; SSM11-02 (abstract).
  96. Querol Sans M, Chen JW, Weissleder R, Bogdanov AA. Myeloperoxidase activity imaging using (67)Ga labeled substrate. Mol Imaging Biol. 2005 Nov-Dec; 7(6):403-10. PMID: 16292477.
    Citations: 5     Fields:    Translation:AnimalsCells
  97. Chen JW, Wasserman BA. Vulnerable plaque imaging. Neuroimaging Clin N Am. 2005 Aug; 15(3):609-21, xi. PMID: 16360592.
    Citations: 4     Fields:    Translation:Humans
  98. Querol M, Chen JW, Weissleder R, Bogdanov A. DTPA-bisamide-based MR sensor agents for peroxidase imaging. Org Lett. 2005 Apr 28; 7(9):1719-22. PMID: 15844889.
    Citations: 35     Fields:    
  99. Chen JW/Querol Sans M, Weissleder R, Bogdanov A. Myeloperoxidase activity imaging using 67Ga Labeled substrate. Molecular Imaging and Biology. 2005; 7(6):403-410.
  100. Querol M, Chen JW, Weissleder R, Bogdanov A . DTPA-bis-amide based MR sensor agents for peroxidase imaging. Organic Letters (Peer-reviewed original articles in organic chemistry). 2005; 7(9):1719-1722.
  101. Chen JW, Pham W, Weissleder R, Bogdanov A. Molecular imaging of human myeloperoxidase: a potential target for imaging unstable plaques in atherosclerosis. Proceedings of the Radiological Society of North America. 2004; SSG03-03 (abstract).
  102. Chen JW, Pham W, Weissleder R, Bogdanov A. Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis. Magn Reson Med. 2004 Nov; 52(5):1021-8. PMID: 15508166.
    Citations: 40     Fields:    Translation:HumansCells
  103. Chen JW, Pham W, Weissleder R, Bogdanov A. Imaging of human myeloperoxidase activity using MR signal amplification. Proceedings of the American Chemical Society. 2004; INOR 302 (abstract).
  104. Chen JW, Weissleder R, Bogdanov A. Molecular imaging of human myeloperoxidase using MR signal amplification approach. Proceedings of the Academy of Molecular Imaging in: Molecular Imaging and Biology. 2004; 6(2):77.
  105. Bogdanov A, Chen JW, Kang HW, Weissleder R. Magnetic Resonance Signal Amplification Probes. Molecular Imaging: An Essential Tool in Preclinical Research, Diagnostic Imaging, and Therapy. 2004; 147-157.
  106. Chen JW, Pham W, Weissleder R, Bogdanov A. Enzymatically-activated polymerizing substrate for T2 weighted and high field MR imaging. Proceedings of the Radiological Society of North America. 2003; Q17-1352 (abstract).
  107. Chen JW, Petrovsky A, Weissleder R, Bogdanov, A. Novel Enzyme-Mediated Polymerizing Magnetic Resonance Imaging Signal Amplification (MRAMP) Contrast Agents. Proceedings of the Radiological Society of North America. 2002; J11-849 (abstract).
  108. Chen JW, Belford RL, Clarkson RB. Second-Sphere and Outer-Sphere Proton Relaxation of Paramagnetic Contrast Agents. J Phys Chem B. 1998; 102:2117-2130.
  109. Chen JW. (Ph.D. Thesis) Rotational dynamics and proton relaxation of MRI paramagnetic contrast agents. 1997.
  110. Wiener EC, Auteri FP, Chen JW, Brechbiel MW, Gansow OA, Schneider DJ, Belford RL, Clarkson RB, Lauterbur PC. Molecular Dynamics of Ion-Chelate Complexes Attached to StarburstTM Dendrimers. J Am Chem Soc. 1996; 118:7774-7782.
  111. Chen JW, Clarkson RB, Belford RL. Rotational Dynamics of MRI Paramagnetic Contrast Agents in Viscous Media. J Phys Chem. 1996; 100:8093-8100.
  112. Chen JW, Auteri FP, Budil DE, Belford RL, Clarkson RB. Use of EPR to Investigate Rotational Dynamics of MRI Paramagnetic Contrast Agents. J Phys Chem. 1994; 98:13452.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.