Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Stephen Charles Blacklow, Ph.D., M.D.

Co-Author

This page shows the publications co-authored by Stephen Blacklow and Jon Aster.
Connection Strength

5.535
  1. The Varied Roles of Notch in Cancer. Annu Rev Pathol. 2017 Jan 24; 12:245-275.
    View in: PubMed
    Score: 0.708
  2. Targeting the Notch pathway: twists and turns on the road to rational therapeutics. J Clin Oncol. 2012 Jul 01; 30(19):2418-20.
    View in: PubMed
    Score: 0.516
  3. Notch signaling in leukemia. Annu Rev Pathol. 2008; 3:587-613.
    View in: PubMed
    Score: 0.382
  4. The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent. Biochemistry. 1999 Apr 13; 38(15):4736-42.
    View in: PubMed
    Score: 0.208
  5. Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma. Am J Surg Pathol. 2017 Nov; 41(11):1473-1482.
    View in: PubMed
    Score: 0.189
  6. The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia. PLoS One. 2017; 12(10):e0185762.
    View in: PubMed
    Score: 0.188
  7. Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells. Sci Signal. 2017 May 02; 10(477).
    View in: PubMed
    Score: 0.182
  8. Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the ?-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case. Cold Spring Harb Mol Case Stud. 2015 Oct; 1(1):a000539.
    View in: PubMed
    Score: 0.163
  9. Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch. Dev Cell. 2015 Jun 22; 33(6):729-36.
    View in: PubMed
    Score: 0.160
  10. Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. Structure. 2015 Jul 07; 23(7):1227-35.
    View in: PubMed
    Score: 0.160
  11. NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):705-10.
    View in: PubMed
    Score: 0.144
  12. Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem. 2013 Aug 30; 288(35):25477-25489.
    View in: PubMed
    Score: 0.140
  13. Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. PLoS One. 2011; 6(10):e25645.
    View in: PubMed
    Score: 0.124
  14. Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci U S A. 2011 Sep 06; 108(36):14908-13.
    View in: PubMed
    Score: 0.122
  15. Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure. 2011 Apr 13; 19(4):546-54.
    View in: PubMed
    Score: 0.120
  16. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol. 2010 Nov; 17(11):1312-7.
    View in: PubMed
    Score: 0.116
  17. Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. J Pathol. 2011 Jan; 223(2):262-73.
    View in: PubMed
    Score: 0.116
  18. Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood. 2010 Dec 16; 116(25):5455-64.
    View in: PubMed
    Score: 0.115
  19. Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS One. 2009 Aug 24; 4(8):e6613.
    View in: PubMed
    Score: 0.107
  20. Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood. 2009 Apr 30; 113(18):4381-90.
    View in: PubMed
    Score: 0.102
  21. Mutational and energetic studies of Notch 1 transcription complexes. J Mol Biol. 2008 Feb 08; 376(1):131-40.
    View in: PubMed
    Score: 0.095
  22. Structural basis for autoinhibition of Notch. Nat Struct Mol Biol. 2007 Apr; 14(4):295-300.
    View in: PubMed
    Score: 0.091
  23. Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2103-8.
    View in: PubMed
    Score: 0.090
  24. Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol Cell Biol. 2006 Aug; 26(16):6261-71.
    View in: PubMed
    Score: 0.086
  25. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 2006 Aug 01; 20(15):2096-109.
    View in: PubMed
    Score: 0.086
  26. Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol Cell Biol. 2006 Jun; 26(12):4642-51.
    View in: PubMed
    Score: 0.085
  27. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 2006 Mar 10; 124(5):973-83.
    View in: PubMed
    Score: 0.084
  28. Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol. 2004 Nov; 24(21):9265-73.
    View in: PubMed
    Score: 0.077
  29. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004 Oct 08; 306(5694):269-71.
    View in: PubMed
    Score: 0.076
  30. Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1. Biochemistry. 2003 Jun 17; 42(23):7061-7.
    View in: PubMed
    Score: 0.070
  31. Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. J Biol Chem. 2003 Jun 06; 278(23):21232-9.
    View in: PubMed
    Score: 0.068
  32. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol. 2003 Jan; 23(2):655-64.
    View in: PubMed
    Score: 0.067
  33. Notch signaling as a therapeutic target. Curr Opin Chem Biol. 2002 Aug; 6(4):501-9.
    View in: PubMed
    Score: 0.066
  34. Calcium depletion dissociates and activates heterodimeric notch receptors. Mol Cell Biol. 2000 Mar; 20(5):1825-35.
    View in: PubMed
    Score: 0.055
  35. A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Cell Rep. 2017 Oct 17; 21(3):784-797.
    View in: PubMed
    Score: 0.047
  36. Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene. 2016 11 24; 35(47):6077-6086.
    View in: PubMed
    Score: 0.043
  37. Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):E4946-53.
    View in: PubMed
    Score: 0.038
  38. Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell. 2013 Mar 18; 23(3):390-405.
    View in: PubMed
    Score: 0.034
  39. T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20060-5.
    View in: PubMed
    Score: 0.031
  40. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17761-6.
    View in: PubMed
    Score: 0.031
  41. Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011 Sep 06; 108(36):14902-7.
    View in: PubMed
    Score: 0.030
  42. Notch dimerization is required for leukemogenesis and T-cell development. Genes Dev. 2010 Nov 01; 24(21):2395-407.
    View in: PubMed
    Score: 0.029
  43. Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors. PLoS One. 2010 Feb 08; 5(2):e9094.
    View in: PubMed
    Score: 0.028
  44. Direct inhibition of the NOTCH transcription factor complex. Nature. 2009 Nov 12; 462(7270):182-8.
    View in: PubMed
    Score: 0.027
  45. Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. J Biol Chem. 2008 Mar 21; 283(12):8046-54.
    View in: PubMed
    Score: 0.024
  46. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet. 2000 Dec; 26(4):484-9.
    View in: PubMed
    Score: 0.015
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.