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Stephen Charles Blacklow, Ph.D., M.D.

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Mentoring
Available: 10/24/14, Expires: 10/01/19

A major focus of my research group is to understand how Notch receptors are activated in normal and pathogenic states. MD student scholarly projects would be directed toward understanding specific facets of the Notch signal transduction mechanism using molecular and/or biochemical approaches.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35CA220340 (BLACKLOW, STEPHEN C.) Aug 1, 2017 - Jul 31, 2024
    NIH/NCI
    Notch Signaling in Cancer
    Role: Principal Investigator
  2. R13HD088000 (BLACKLOW, STEPHEN C.) May 10, 2016 - Apr 30, 2017
    NIH/NICHD
    2016 Notch Gordon Research Conference & Gordon Research Seminar
    Role: Principal Investigator
  3. P50GM107618 (SORGER, PETER KARL) Sep 1, 2014 - May 31, 2019
    NIH/NIGMS
    The HMS Laboratory of Systems Pharmacology
    Role: Co-Principal Investigator
  4. R13HD080297 (BLACKLOW, STEPHEN C.) May 10, 2014 - Apr 30, 2015
    NIH/NICHD
    2014 Notch Signaling in Development &Disease Gordon Research Conference/Seminar
    Role: Principal Investigator
  5. R01CA119130 (BLACKLOW, STEPHEN C.) Apr 1, 2006 - Aug 31, 2006
    NIH/NCI
    Oncogenic Notch Signaling: Structural Studies
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Drabek AA, Loparo JJ, Blacklow SC. A Flow-Extension Tethered Particle Motion Assay for Single-Molecule Proteolysis. Biochemistry. 2019 May 21; 58(20):2509-2518. PMID: 30946563.
    Citations:    
  2. Rogers JM, Waters CT, Seegar TCM, Jarrett SM, Hallworth AN, Blacklow SC, Bulyk ML. Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes. Mol Cell. 2019 Apr 18; 74(2):245-253.e6. PMID: 30826165.
    Citations:    
  3. Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, Little SC, Vahedi G, Pear WS, Faryabi RB. Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques. Mol Cell. 2019 03 21; 73(6):1174-1190.e12. PMID: 30745086.
    Citations:    
  4. LaRochelle JR, Fodor M, Vemulapalli V, Mohseni M, Wang P, Stams T, LaMarche MJ, Chopra R, Acker MG, Blacklow SC. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. Nat Commun. 2018 10 30; 9(1):4508. PMID: 30375388.
    Citations:    Fields:    
  5. Tveriakhina L, Schuster-Gossler K, Jarrett SM, Andrawes MB, Rohrbach M, Blacklow SC, Gossler A. The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro. Elife. 2018 10 05; 7. PMID: 30289388.
    Citations:    Fields:    
  6. Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 09 21; 13(9):2438-2448. PMID: 30102854.
    Citations:    Fields:    
  7. Fodor M, Price E, Wang P, Lu H, Argintaru A, Chen Z, Glick M, Hao HX, Kato M, Koenig R, LaRochelle JR, Liu G, McNeill E, Majumdar D, Nishiguchi GA, Perez LB, Paris G, Quinn CM, Ramsey T, Sendzik M, Shultz MD, Williams SL, Stams T, Blacklow SC, Acker MG, LaMarche MJ. Dual Allosteric Inhibition of SHP2 Phosphatase. ACS Chem Biol. 2018 03 16; 13(3):647-656. PMID: 29304282.
    Citations: 2     Fields:    
  8. Lovendahl KN, Blacklow SC, Gordon WR. The Molecular Mechanism of Notch Activation. Adv Exp Med Biol. 2018; 1066:47-58. PMID: 30030821.
    Citations:    Fields:    
  9. Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC. Structural Basis for Regulated Proteolysis by the a-Secretase ADAM10. Cell. 2017 Dec 14; 171(7):1638-1648.e7. PMID: 29224781.
    Citations: 6     Fields:    Translation:HumansCells
  10. Pajcini KV, Xu L, Shao L, Petrovic J, Palasiewicz K, Ohtani Y, Bailis W, Lee C, Wertheim GB, Mani R, Muthusamy N, Li Y, Meijerink JPP, Blacklow SC, Faryabi RB, Cherry S, Pear WS. MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia. Sci Signal. 2017 11 14; 10(505). PMID: 29138297.
    Citations:    Fields:    Translation:HumansAnimalsCells
  11. Sajed DP, Faquin WC, Carey C, Severson EA, H Afrogheh A, A Johnson C, Blacklow SC, Chau NG, Lin DT, Krane JF, Jo VY, Garcia JJ, Sholl LM, Aster JC. Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma. Am J Surg Pathol. 2017 Nov; 41(11):1473-1482. PMID: 28914715.
    Citations: 2     Fields:    Translation:Humans
  12. LaRochelle JR, Fodor M, Ellegast JM, Liu X, Vemulapalli V, Mohseni M, Stams T, Buhrlage SJ, Stegmaier K, LaMarche MJ, Acker MG, Blacklow SC. Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. Bioorg Med Chem. 2017 12 15; 25(24):6479-6485. PMID: 29089257.
    Citations: 1     Fields:    Translation:HumansCells
  13. Ryan RJH, Petrovic J, Rausch DM, Zhou Y, Lareau CA, Kluk MJ, Christie AL, Lee WY, Tarjan DR, Guo B, Donohue LKH, Gillespie SM, Nardi V, Hochberg EP, Blacklow SC, Weinstock DM, Faryabi RB, Bernstein BE, Aster JC, Pear WS. A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas. Cell Rep. 2017 Oct 17; 21(3):784-797. PMID: 29045844.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  14. Choi SH, Severson E, Pear WS, Liu XS, Aster JC, Blacklow SC. The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia. PLoS One. 2017; 12(10):e0185762. PMID: 29023469.
    Citations: 1     Fields:    Translation:HumansCells
  15. McMillan BJ, Zimmerman B, Egan ED, Lofgren M, Xu X, Hesser A, Blacklow SC. Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations. Glycobiology. 2017 08 01; 27(8):777-786. PMID: 28334865.
    Citations: 2     Fields:    Translation:HumansCells
  16. McMillan BJ, Tibbe C, Drabek AA, Seegar TCM, Blacklow SC, Klein T. Structural Basis for Regulation of ESCRT-III Complexes by Lgd. Cell Rep. 2017 05 30; 19(9):1750-1757. PMID: 28564595.
    Citations: 2     Fields:    Translation:AnimalsCells
  17. Blacklow SC. Signal Transduction: Notch catches a Jagged edge. Nat Chem Biol. 2017 05 17; 13(6):570-571. PMID: 28514425.
    Citations:    Fields:    Translation:Cells
  18. Severson E, Arnett KL, Wang H, Zang C, Taing L, Liu H, Pear WS, Shirley Liu X, Blacklow SC, Aster JC. Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells. Sci Signal. 2017 May 02; 10(477). PMID: 28465412.
    Citations:    Fields:    Translation:HumansAnimalsCells
  19. Durzynska I, Xu X, Adelmant G, Ficarro SB, Marto JA, Sliz P, Uljon S, Blacklow SC. STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1. Structure. 2017 02 07; 25(2):287-294. PMID: 28089446.
    Citations: 1     Fields:    Translation:HumansCells
  20. Aster JC, Pear WS, Blacklow SC. The Varied Roles of Notch in Cancer. Annu Rev Pathol. 2017 Jan 24; 12:245-275. PMID: 27959635.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  21. Zimmerman B, Kelly B, McMillan BJ, Seegar TCM, Dror RO, Kruse AC, Blacklow SC. Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket. Cell. 2016 11 03; 167(4):1041-1051.e11. PMID: 27881302.
    Citations: 25     Fields:    Translation:HumansCells
  22. McMillan BJ, Tibbe C, Jeon H, Drabek AA, Klein T, Blacklow SC. Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein. Cell Rep. 2016 08 02; 16(5):1211-1217. PMID: 27452459.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  23. Guo B, McMillan BJ, Blacklow SC. Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction. Curr Opin Struct Biol. 2016 12; 41:38-45. PMID: 27285058.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  24. Bernasconi-Elias P, Hu T, Jenkins D, Firestone B, Gans S, Kurth E, Capodieci P, Deplazes-Lauber J, Petropoulos K, Thiel P, Ponsel D, Hee Choi S, LeMotte P, London A, Goetcshkes M, Nolin E, Jones MD, Slocum K, Kluk MJ, Weinstock DM, Christodoulou A, Weinberg O, Jaehrling J, Ettenberg SA, Buckler A, Blacklow SC, Aster JC, Fryer CJ. Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies. Oncogene. 2016 11 24; 35(47):6077-6086. PMID: 27157619.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  25. LaRochelle JR, Fodor M, Xu X, Durzynska I, Fan L, Stams T, Chan HM, LaMarche MJ, Chopra R, Wang P, Fortin PD, Acker MG, Blacklow SC. Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry. 2016 Apr 19; 55(15):2269-77. PMID: 27030275.
    Citations: 5     Fields:    Translation:HumansCells
  26. Uljon S, Xu X, Durzynska I, Stein S, Adelmant G, Marto JA, Pear WS, Blacklow SC. Structural Basis for Substrate Selectivity of the E3 Ligase COP1. Structure. 2016 05 03; 24(5):687-696. PMID: 27041596.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  27. Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P. Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 07; 7:10882. PMID: 26947396.
    Citations: 24     Fields:    
  28. Knoechel B, Bhatt A, Pan L, Pedamallu CS, Severson E, Gutierrez A, Dorfman DM, Kuo FC, Kluk M, Kung AL, Zweidler-McKay P, Meyerson M, Blacklow SC, DeAngelo DJ, Aster JC. Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the ?-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case. Cold Spring Harb Mol Case Stud. 2015 Oct; 1(1):a000539. PMID: 27148573.
    Citations: 8     Fields:    
  29. Gordon WR, Zimmerman B, He L, Miles LJ, Huang J, Tiyanont K, McArthur DG, Aster JC, Perrimon N, Loparo JJ, Blacklow SC. Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch. Dev Cell. 2015 Jun 22; 33(6):729-36. PMID: 26051539.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  30. Xu X, Choi SH, Hu T, Tiyanont K, Habets R, Groot AJ, Vooijs M, Aster JC, Chopra R, Fryer C, Blacklow SC. Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. Structure. 2015 Jul 07; 23(7):1227-35. PMID: 26051713.
    Citations: 9     Fields:    Translation:HumansCells
  31. Habets RA, Groot AJ, Yahyanejad S, Tiyanont K, Blacklow SC, Vooijs M. Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17. J Biol Chem. 2015 Jun 05; 290(23):14705-16. PMID: 25918160.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  32. McMillan BJ, Schnute B, Ohlenhard N, Zimmerman B, Miles L, Beglova N, Klein T, Blacklow SC. A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases. Mol Cell. 2015 Mar 05; 57(5):912-924. PMID: 25747658.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  33. Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WS. Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia. Proc Natl Acad Sci U S A. 2014 Nov 18; 111(46):E4946-53. PMID: 25369933.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  34. McKeown MR, Shaw DL, Fu H, Liu S, Xu X, Marineau JJ, Huang Y, Zhang X, Buckley DL, Kadam A, Zhang Z, Blacklow SC, Qi J, Zhang W, Bradner JE. Biased multicomponent reactions to develop novel bromodomain inhibitors. J Med Chem. 2014 Nov 13; 57(21):9019-27. PMID: 25314271.
    Citations: 11     Fields:    Translation:HumansCells
  35. Arnett KL, Blacklow SC. Analyzing the nuclear complexes of Notch signaling by electrophoretic mobility shift assay. Methods Mol Biol. 2014; 1187:231-45. PMID: 25053494.
    Citations: 1     Fields:    Translation:HumansCells
  36. Wang H, Zang C, Taing L, Arnett KL, Wong YJ, Pear WS, Blacklow SC, Liu XS, Aster JC. NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers. Proc Natl Acad Sci U S A. 2014 Jan 14; 111(2):705-10. PMID: 24374627.
    Citations: 53     Fields:    Translation:HumansCells
  37. Blacklow SC. Refining a Jagged edge. Structure. 2013 Dec 03; 21(12):2100-1. PMID: 24315457.
    Citations:    Fields:    Translation:Humans
  38. Wittinghofer A, Martin JB, Blacklow S. Proteins special issue of biopolymers. Biopolymers. 2013 Nov; 99(11):807-8. PMID: 23893350.
    Citations:    Fields:    
  39. Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, Blacklow SC. Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1. J Biol Chem. 2013 Aug 30; 288(35):25477-89. PMID: 23839946.
    Citations: 32     Fields:    Translation:HumansCells
  40. Tiyanont K, Wales TE, Siebel CW, Engen JR, Blacklow SC. Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region. J Mol Biol. 2013 Sep 09; 425(17):3192-204. PMID: 23747483.
    Citations: 5     Fields:    Translation:HumansCells
  41. Roti G, Carlton A, Ross KN, Markstein M, Pajcini K, Su AH, Perrimon N, Pear WS, Kung AL, Blacklow SC, Aster JC, Stegmaier K. Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell. 2013 Mar 18; 23(3):390-405. PMID: 23434461.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  42. Aster JC, Blacklow SC. Targeting the Notch pathway: twists and turns on the road to rational therapeutics. J Clin Oncol. 2012 Jul 01; 30(19):2418-20. PMID: 22585704.
    Citations: 29     Fields:    Translation:HumansCells
  43. O'Donovan DJ, Stokes-Rees I, Nam Y, Blacklow SC, Schröder GF, Brunger AT, Sliz P. A grid-enabled web service for low-resolution crystal structure refinement. Acta Crystallogr D Biol Crystallogr. 2012 Mar; 68(Pt 3):261-7. PMID: 22349228.
    Citations: 5     Fields:    
  44. Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC. Conformational locking upon cooperative assembly of notch transcription complexes. Structure. 2012 Feb 08; 20(2):340-9. PMID: 22325781.
    Citations: 23     Fields:    Translation:HumansCells
  45. Germar K, Dose M, Konstantinou T, Zhang J, Wang H, Lobry C, Arnett KL, Blacklow SC, Aifantis I, Aster JC, Gounari F. T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling. Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20060-5. PMID: 22109558.
    Citations: 58     Fields:    Translation:AnimalsCells
  46. Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, Leigh IM, Collisson EA, Gordon PB, Jakkula L, Pennypacker S, Zou Y, Sharma M, North JP, Vemula SS, Mauro TM, Neuhaus IM, Leboit PE, Hur JS, Park K, Huh N, Kwok PY, Arron ST, Massion PP, Bale AE, Haussler D, Cleaver JE, Gray JW, Spellman PT, South AP, Aster JC, Blacklow SC, Cho RJ. Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17761-6. PMID: 22006338.
    Citations: 124     Fields:    Translation:HumansCells
  47. Aster JC, Bodnar N, Xu L, Karnell F, Milholland JM, Maillard I, Histen G, Nam Y, Blacklow SC, Pear WS. Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. PLoS One. 2011; 6(10):e25645. PMID: 22022427.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  48. Zhao B, Zou J, Wang H, Johannsen E, Peng CW, Quackenbush J, Mar JC, Morton CC, Freedman ML, Blacklow SC, Aster JC, Bernstein BE, Kieff E. Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci U S A. 2011 Sep 06; 108(36):14902-7. PMID: 21746931.
    Citations: 71     Fields:    Translation:HumansCells
  49. Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC. Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci U S A. 2011 Sep 06; 108(36):14908-13. PMID: 21737748.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  50. Tiyanont K, Wales TE, Aste-Amezaga M, Aster JC, Engen JR, Blacklow SC. Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation. Structure. 2011 Apr 13; 19(4):546-54. PMID: 21481777.
    Citations: 23     Fields:    Translation:HumansCells
  51. Calderwood MA, Lee S, Holthaus AM, Blacklow SC, Kieff E, Johannsen E. Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth. Virology. 2011 May 25; 414(1):19-25. PMID: 21440926.
    Citations: 7     Fields:    Translation:HumansCells
  52. Del Bianco C, Vedenko A, Choi SH, Berger MF, Shokri L, Bulyk ML, Blacklow SC. Notch and MAML-1 complexation do not detectably alter the DNA binding specificity of the transcription factor CSL. PLoS One. 2010 Nov 24; 5(11):e15034. PMID: 21124806.
    Citations: 14     Fields:    Translation:HumansCells
  53. Arnett KL, Hass M, McArthur DG, Ilagan MX, Aster JC, Kopan R, Blacklow SC. Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes. Nat Struct Mol Biol. 2010 Nov; 17(11):1312-7. PMID: 20972443.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  54. Aster JC, Blacklow SC, Pear WS. Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies. J Pathol. 2011 Jan; 223(2):262-73. PMID: 20967796.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  55. Liu H, Chi AW, Arnett KL, Chiang MY, Xu L, Shestova O, Wang H, Li YM, Bhandoola A, Aster JC, Blacklow SC, Pear WS. Notch dimerization is required for leukemogenesis and T-cell development. Genes Dev. 2010 Nov 01; 24(21):2395-407. PMID: 20935071.
    Citations: 24     Fields:    Translation:AnimalsCells
  56. Ashworth TD, Pear WS, Chiang MY, Blacklow SC, Mastio J, Xu L, Kelliher M, Kastner P, Chan S, Aster JC. Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood. 2010 Dec 16; 116(25):5455-64. PMID: 20852131.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  57. Keeshan K, Bailis W, Dedhia PH, Vega ME, Shestova O, Xu L, Toscano K, Uljon SN, Blacklow SC, Pear WS. Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood. 2010 Dec 02; 116(23):4948-57. PMID: 20805362.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  58. Dedhia PH, Keeshan K, Uljon S, Xu L, Vega ME, Shestova O, Zaks-Zilberman M, Romany C, Blacklow SC, Pear WS. Differential ability of Tribbles family members to promote degradation of C/EBPalpha and induce acute myelogenous leukemia. Blood. 2010 Aug 26; 116(8):1321-8. PMID: 20410507.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  59. Aste-Amézaga M, Zhang N, Lineberger JE, Arnold BA, Toner TJ, Gu M, Huang L, Vitelli S, Vo KT, Haytko P, Zhao JZ, Baleydier F, L'Heureux S, Wang H, Gordon WR, Thoryk E, Andrawes MB, Tiyanont K, Stegmaier K, Roti G, Ross KN, Franlin LL, Wang H, Wang F, Chastain M, Bett AJ, Audoly LP, Aster JC, Blacklow SC, Huber HE. Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors. PLoS One. 2010 Feb 08; 5(2):e9094. PMID: 20161710.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  60. Kovall RA, Blacklow SC. Mechanistic insights into Notch receptor signaling from structural and biochemical studies. Curr Top Dev Biol. 2010; 92:31-71. PMID: 20816392.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  61. Moellering RE, Cornejo M, Davis TN, Del Bianco C, Aster JC, Blacklow SC, Kung AL, Gilliland DG, Verdine GL, Bradner JE. Direct inhibition of the NOTCH transcription factor complex. Nature. 2009 Nov 12; 462(7270):182-8. PMID: 19907488.
    Citations: 231     Fields:    Translation:HumansAnimalsCells
  62. Gordon WR, Vardar-Ulu D, L'Heureux S, Ashworth T, Malecki MJ, Sanchez-Irizarry C, McArthur DG, Histen G, Mitchell JL, Aster JC, Blacklow SC. Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS One. 2009 Aug 24; 4(8):e6613. PMID: 19701457.
    Citations: 41     Fields:    Translation:HumansCells
  63. Yashiro-Ohtani Y, He Y, Ohtani T, Jones ME, Shestova O, Xu L, Fang TC, Chiang MY, Intlekofer AM, Blacklow SC, Zhuang Y, Pear WS. Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. Genes Dev. 2009 Jul 15; 23(14):1665-76. PMID: 19605688.
    Citations: 64     Fields:    Translation:AnimalsCells
  64. Gordon WR, Roy M, Vardar-Ulu D, Garfinkel M, Mansour MR, Aster JC, Blacklow SC. Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood. 2009 Apr 30; 113(18):4381-90. PMID: 19075186.
    Citations: 54     Fields:    Translation:HumansCells
  65. Gordon WR, Arnett KL, Blacklow SC. The molecular logic of Notch signaling--a structural and biochemical perspective. J Cell Sci. 2008 Oct 01; 121(Pt 19):3109-19. PMID: 18799787.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  66. Li K, Li Y, Wu W, Gordon WR, Chang DW, Lu M, Scoggin S, Fu T, Vien L, Histen G, Zheng J, Martin-Hollister R, Duensing T, Singh S, Blacklow SC, Yao Z, Aster JC, Zhou BB. Modulation of Notch signaling by antibodies specific for the extracellular negative regulatory region of NOTCH3. J Biol Chem. 2008 Mar 21; 283(12):8046-54. PMID: 18182388.
    Citations: 68     Fields:    Translation:HumansCells
  67. Estrada K, Fisher C, Blacklow SC. Unfolding of the RAP-D3 helical bundle facilitates dissociation of RAP-receptor complexes. Biochemistry. 2008 Feb 12; 47(6):1532-9. PMID: 18177055.
    Citations: 6     Fields:    Translation:Cells
  68. Aster JC, Pear WS, Blacklow SC. Notch signaling in leukemia. Annu Rev Pathol. 2008; 3:587-613. PMID: 18039126.
    Citations: 115     Fields:    Translation:HumansAnimalsCells
  69. Del Bianco C, Aster JC, Blacklow SC. Mutational and energetic studies of Notch 1 transcription complexes. J Mol Biol. 2008 Feb 08; 376(1):131-40. PMID: 18155729.
    Citations: 23     Fields:    Translation:HumansCells
  70. Blacklow SC. Versatility in ligand recognition by LDL receptor family proteins: advances and frontiers. Curr Opin Struct Biol. 2007 Aug; 17(4):419-26. PMID: 17870468.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  71. Fang TC, Yashiro-Ohtani Y, Del Bianco C, Knoblock DM, Blacklow SC, Pear WS. Notch directly regulates Gata3 expression during T helper 2 cell differentiation. Immunity. 2007 Jul; 27(1):100-10. PMID: 17658278.
    Citations: 144     Fields:    Translation:AnimalsCells
  72. Koduri V, Blacklow SC. Requirement for natively unstructured regions of mesoderm development candidate 2 in promoting low-density lipoprotein receptor-related protein 6 maturation. Biochemistry. 2007 Jun 05; 46(22):6570-7. PMID: 17488095.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  73. Gordon WR, Vardar-Ulu D, Histen G, Sanchez-Irizarry C, Aster JC, Blacklow SC. Structural basis for autoinhibition of Notch. Nat Struct Mol Biol. 2007 Apr; 14(4):295-300. PMID: 17401372.
    Citations: 119     Fields:    Translation:HumansCells
  74. Nam Y, Sliz P, Pear WS, Aster JC, Blacklow SC. Cooperative assembly of higher-order Notch complexes functions as a switch to induce transcription. Proc Natl Acad Sci U S A. 2007 Feb 13; 104(7):2103-8. PMID: 17284587.
    Citations: 57     Fields:    Translation:HumansCells
  75. Chiang MY, Xu ML, Histen G, Shestova O, Roy M, Nam Y, Blacklow SC, Sacks DB, Pear WS, Aster JC. Identification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1. Mol Cell Biol. 2006 Aug; 26(16):6261-71. PMID: 16880534.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  76. Weng AP, Millholland JM, Yashiro-Ohtani Y, Arcangeli ML, Lau A, Wai C, Del Bianco C, Rodriguez CG, Sai H, Tobias J, Li Y, Wolfe MS, Shachaf C, Felsher D, Blacklow SC, Pear WS, Aster JC. c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma. Genes Dev. 2006 Aug 01; 20(15):2096-109. PMID: 16847353.
    Citations: 304     Fields:    Translation:HumansAnimalsCells
  77. Malecki MJ, Sanchez-Irizarry C, Mitchell JL, Histen G, Xu ML, Aster JC, Blacklow SC. Leukemia-associated mutations within the NOTCH1 heterodimerization domain fall into at least two distinct mechanistic classes. Mol Cell Biol. 2006 Jun; 26(12):4642-51. PMID: 16738328.
    Citations: 97     Fields:    Translation:HumansCells
  78. Lee D, Walsh JD, Mikhailenko I, Yu P, Migliorini M, Wu Y, Krueger S, Curtis JE, Harris B, Lockett S, Blacklow SC, Strickland DK, Wang YX. RAP uses a histidine switch to regulate its interaction with LRP in the ER and Golgi. Mol Cell. 2006 May 05; 22(3):423-30. PMID: 16678114.
    Citations: 25     Fields:    Translation:AnimalsCells
  79. Fisher C, Beglova N, Blacklow SC. Structure of an LDLR-RAP complex reveals a general mode for ligand recognition by lipoprotein receptors. Mol Cell. 2006 Apr 21; 22(2):277-83. PMID: 16630895.
    Citations: 65     Fields:    Translation:HumansCells
  80. Nam Y, Sliz P, Song L, Aster JC, Blacklow SC. Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell. 2006 Mar 10; 124(5):973-83. PMID: 16530044.
    Citations: 154     Fields:    Translation:HumansAnimalsCells
  81. Blacklow SC. A new niche for Notch on Deltex? Structure. 2005 Nov; 13(11):1579-80. PMID: 16271878.
    Citations:    Fields:    Translation:AnimalsCells
  82. Tan Z, Blacklow SC, Cornish VW, Forster AC. De novo genetic codes and pure translation display. Methods. 2005 Jul; 36(3):279-90. PMID: 16076454.
    Citations: 13     Fields:    Translation:Cells
  83. Beglova N, Blacklow SC. The LDL receptor: how acid pulls the trigger. Trends Biochem Sci. 2005 Jun; 30(6):309-17. PMID: 15950875.
    Citations: 32     Fields:    Translation:HumansCells
  84. Abdul-Aziz D, Fisher C, Beglova N, Blacklow SC. Folding and binding integrity of variants of a prototype ligand-binding module from the LDL receptor possessing multiple alanine substitutions. Biochemistry. 2005 Apr 05; 44(13):5075-85. PMID: 15794645.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  85. Stolt PC, Chen Y, Liu P, Bock HH, Blacklow SC, Herz J. Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction. J Biol Chem. 2005 Mar 11; 280(10):9671-7. PMID: 15632144.
    Citations: 12     Fields:    Translation:AnimalsCells
  86. Jeon H, Blacklow SC. Structure and physiologic function of the low-density lipoprotein receptor. Annu Rev Biochem. 2005; 74:535-62. PMID: 15952897.
    Citations: 51     Fields:    Translation:HumansCells
  87. Beglova N, Jeon H, Fisher C, Blacklow SC. Structural features of the low-density lipoprotein receptor facilitating ligand binding and release. Biochem Soc Trans. 2004 Nov; 32(Pt 5):721-3. PMID: 15493997.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  88. Sanchez-Irizarry C, Carpenter AC, Weng AP, Pear WS, Aster JC, Blacklow SC. Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats. Mol Cell Biol. 2004 Nov; 24(21):9265-73. PMID: 15485896.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  89. Beglova N, Jeon H, Fisher C, Blacklow SC. Cooperation between fixed and low pH-inducible interfaces controls lipoprotein release by the LDL receptor. Mol Cell. 2004 Oct 22; 16(2):281-92. PMID: 15494314.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  90. Forster AC, Cornish VW, Blacklow SC. Pure translation display. Anal Biochem. 2004 Oct 15; 333(2):358-64. PMID: 15450813.
    Citations: 9     Fields:    Translation:Cells
  91. Tan Z, Forster AC, Blacklow SC, Cornish VW. Amino acid backbone specificity of the Escherichia coli translation machinery. J Am Chem Soc. 2004 Oct 13; 126(40):12752-3. PMID: 15469251.
    Citations: 27     Fields:    Translation:Cells
  92. Weng AP, Ferrando AA, Lee W, Morris JP, Silverman LB, Sanchez-Irizarry C, Blacklow SC, Look AT, Aster JC. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science. 2004 Oct 08; 306(5694):269-71. PMID: 15472075.
    Citations: 876     Fields:    Translation:HumansCells
  93. Stolt PC, Vardar D, Blacklow SC. The dual-function disabled-1 PTB domain exhibits site independence in binding phosphoinositide and peptide ligands. Biochemistry. 2004 Aug 31; 43(34):10979-87. PMID: 15323557.
    Citations: 8     Fields:    Translation:AnimalsCells
  94. Blacklow SC. Catching the common cold. Nat Struct Mol Biol. 2004 May; 11(5):388-90. PMID: 15114337.
    Citations: 2     Fields:    Translation:HumansCells
  95. Boswell EJ, Jeon H, Blacklow SC, Downing AK. Global defects in the expression and function of the low density lipoprotein receptor (LDLR) associated with two familial hypercholesterolemia mutations resulting in misfolding of the LDLR epidermal growth factor-AB pair. J Biol Chem. 2004 Jul 16; 279(29):30611-21. PMID: 15100232.
    Citations: 5     Fields:    Translation:HumansCells
  96. Fisher C, Abdul-Aziz D, Blacklow SC. A two-module region of the low-density lipoprotein receptor sufficient for formation of complexes with apolipoprotein E ligands. Biochemistry. 2004 Feb 03; 43(4):1037-44. PMID: 14744149.
    Citations: 31     Fields:    Translation:Cells
  97. Smith JG, Mothes W, Blacklow SC, Cunningham JM. The mature avian leukosis virus subgroup A envelope glycoprotein is metastable, and refolding induced by the synergistic effects of receptor binding and low pH is coupled to infection. J Virol. 2004 Feb; 78(3):1403-10. PMID: 14722295.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  98. Kim PW, Sun ZY, Blacklow SC, Wagner G, Eck MJ. A zinc clasp structure tethers Lck to T cell coreceptors CD4 and CD8. Science. 2003 Sep 19; 301(5640):1725-8. PMID: 14500983.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  99. Vardar D, North CL, Sanchez-Irizarry C, Aster JC, Blacklow SC. Nuclear magnetic resonance structure of a prototype Lin12-Notch repeat module from human Notch1. Biochemistry. 2003 Jun 17; 42(23):7061-7. PMID: 12795601.
    Citations: 16     Fields:    Translation:HumansCells
  100. Forster AC, Tan Z, Nalam MN, Lin H, Qu H, Cornish VW, Blacklow SC. Programming peptidomimetic syntheses by translating genetic codes designed de novo. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6353-7. PMID: 12754376.
    Citations: 36     Fields:    Translation:Cells
  101. Stolt PC, Jeon H, Song HK, Herz J, Eck MJ, Blacklow SC. Origins of peptide selectivity and phosphoinositide binding revealed by structures of disabled-1 PTB domain complexes. Structure. 2003 May; 11(5):569-79. PMID: 12737822.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  102. Nam Y, Weng AP, Aster JC, Blacklow SC. Structural requirements for assembly of the CSL.intracellular Notch1.Mastermind-like 1 transcriptional activation complex. J Biol Chem. 2003 Jun 06; 278(23):21232-9. PMID: 12644465.
    Citations: 62     Fields:    Translation:HumansCells
  103. Jeon H, Blacklow SC. An intramolecular spin of the LDL receptor beta propeller. Structure. 2003 Feb; 11(2):133-6. PMID: 12575931.
    Citations: 1     Fields:    Translation:Cells
  104. Weng AP, Nam Y, Wolfe MS, Pear WS, Griffin JD, Blacklow SC, Aster JC. Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling. Mol Cell Biol. 2003 Jan; 23(2):655-64. PMID: 12509463.
    Citations: 155     Fields:    Translation:HumansAnimalsCells
  105. Nam Y, Aster JC, Blacklow SC. Notch signaling as a therapeutic target. Curr Opin Chem Biol. 2002 Aug; 6(4):501-9. PMID: 12133727.
    Citations: 9     Fields:    Translation:HumansCells
  106. Beglova N, Blacklow SC, Takagi J, Springer TA. Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nat Struct Biol. 2002 Apr; 9(4):282-7. PMID: 11896403.
    Citations: 79     Fields:    Translation:HumansCells
  107. Stone JR, Maki JL, Blacklow SC, Collins T. The SCAN domain of ZNF174 is a dimer. J Biol Chem. 2002 Feb 15; 277(7):5448-52. PMID: 11741982.
    Citations: 11     Fields:    Translation:HumansCells
  108. Koduri V, Blacklow SC. Folding determinants of LDL receptor type A modules. Biochemistry. 2001 Oct 30; 40(43):12801-7. PMID: 11669616.
    Citations: 3     Fields:    Translation:Cells
  109. Forster AC, Weissbach H, Blacklow SC. A simplified reconstitution of mRNA-directed peptide synthesis: activity of the epsilon enhancer and an unnatural amino acid. Anal Biochem. 2001 Oct 01; 297(1):60-70. PMID: 11567528.
    Citations: 17     Fields:    Translation:Cells
  110. Takagi J, Beglova N, Yalamanchili P, Blacklow SC, Springer TA. Definition of EGF-like, closely interacting modules that bear activation epitopes in integrin beta subunits. Proc Natl Acad Sci U S A. 2001 Sep 25; 98(20):11175-80. PMID: 11572973.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  111. Jeon H, Meng W, Takagi J, Eck MJ, Springer TA, Blacklow SC. Implications for familial hypercholesterolemia from the structure of the LDL receptor YWTD-EGF domain pair. Nat Struct Biol. 2001 Jun; 8(6):499-504. PMID: 11373616.
    Citations: 53     Fields:    Translation:HumansCells
  112. Adkins HB, Blacklow SC, Young JA. Two functionally distinct forms of a retroviral receptor explain the nonreciprocal receptor interference among subgroups B, D, and E avian leukosis viruses. J Virol. 2001 Apr; 75(8):3520-6. PMID: 11264341.
    Citations: 26     Fields:    Translation:HumansCells
  113. Beglova N, North CL, Blacklow SC. Backbone dynamics of a module pair from the ligand-binding domain of the LDL receptor. Biochemistry. 2001 Mar 06; 40(9):2808-15. PMID: 11258891.
    Citations: 10     Fields:    Translation:HumansCells
  114. Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD. MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet. 2000 Dec; 26(4):484-9. PMID: 11101851.
    Citations: 164     Fields:    Translation:HumansAnimalsCells
  115. North CL, Blacklow SC. Evidence that familial hypercholesterolemia mutations of the LDL receptor cause limited local misfolding in an LDL-A module pair. Biochemistry. 2000 Oct 31; 39(43):13127-35. PMID: 11052664.
    Citations: 5     Fields:    Translation:HumansCells
  116. North CL, Blacklow SC. Solution structure of the sixth LDL-A module of the LDL receptor. Biochemistry. 2000 Mar 14; 39(10):2564-71. PMID: 10704205.
    Citations: 21     Fields:    Translation:HumansCells
  117. Rand MD, Grimm LM, Artavanis-Tsakonas S, Patriub V, Blacklow SC, Sklar J, Aster JC. Calcium depletion dissociates and activates heterodimeric notch receptors. Mol Cell Biol. 2000 Mar; 20(5):1825-35. PMID: 10669757.
    Citations: 125     Fields:    Translation:HumansAnimalsCells
  118. Williams AJ, Blacklow SC, Collins T. The zinc finger-associated SCAN box is a conserved oligomerization domain. Mol Cell Biol. 1999 Dec; 19(12):8526-35. PMID: 10567577.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  119. Aster JC, Simms WB, Zavala-Ruiz Z, Patriub V, North CL, Blacklow SC. The folding and structural integrity of the first LIN-12 module of human Notch1 are calcium-dependent. Biochemistry. 1999 Apr 13; 38(15):4736-42. PMID: 10200161.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  120. Zhang Z, Komives EA, Sugio S, Blacklow SC, Narayana N, Xuong NH, Stock AM, Petsko GA, Ringe D. The role of water in the catalytic efficiency of triosephosphate isomerase. Biochemistry. 1999 Apr 06; 38(14):4389-97. PMID: 10194358.
    Citations: 7     Fields:    Translation:AnimalsCells
  121. North CL, Blacklow SC. Structural independence of ligand-binding modules five and six of the LDL receptor. Biochemistry. 1999 Mar 30; 38(13):3926-35. PMID: 10194304.
    Citations: 15     Fields:    Translation:HumansCells
  122. Fass D, Blacklow S, Kim PS, Berger JM. Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module. Nature. 1997 Aug 14; 388(6643):691-3. PMID: 9262405.
    Citations: 82     Fields:    Translation:HumansCells
  123. Blacklow SC, Kim PS. Protein folding and calcium binding defects arising from familial hypercholesterolemia mutations of the LDL receptor. Nat Struct Biol. 1996 Sep; 3(9):758-62. PMID: 8784348.
    Citations: 25     Fields:    Translation:HumansCells
  124. Appignani BA, Bhadelia RA, Blacklow SC, Wang AK, Roland SF, Freeman RB. Neuroimaging findings in patients on immunosuppressive therapy: experience with tacrolimus toxicity. AJR Am J Roentgenol. 1996 Mar; 166(3):683-8. PMID: 8623651.
    Citations: 14     Fields:    Translation:Humans
  125. Lu M, Blacklow SC, Kim PS. A trimeric structural domain of the HIV-1 transmembrane glycoprotein. Nat Struct Biol. 1995 Dec; 2(12):1075-82. PMID: 8846219.
    Citations: 246     Fields:    Translation:Cells
  126. Blacklow SC, Lu M, Kim PS. A trimeric subdomain of the simian immunodeficiency virus envelope glycoprotein. Biochemistry. 1995 Nov 21; 34(46):14955-62. PMID: 7578108.
    Citations: 49     Fields:    Translation:Cells
  127. Goldhaber SZ, Simons GR, Elliott CG, Haire WD, Toltzis R, Blacklow SC, Doolittle MH, Weinberg DS. Quantitative plasma D-dimer levels among patients undergoing pulmonary angiography for suspected pulmonary embolism. JAMA. 1993 Dec 15; 270(23):2819-22. PMID: 8133620.
    Citations: 9     Fields:    Translation:Humans
  128. Blacklow SC, Liu KD, Knowles JR. Stepwise improvements in catalytic effectiveness: independence and interdependence in combinations of point mutations of a sluggish triosephosphate isomerase. Biochemistry. 1991 Aug 27; 30(34):8470-6. PMID: 1883832.
    Citations: 7     Fields:    Translation:AnimalsCells
  129. Blacklow SC, Knowles JR. How can a catalytic lesion be offset? The energetics of two pseudorevertant triosephosphate isomerases. Biochemistry. 1990 May 01; 29(17):4099-108. PMID: 2361134.
    Citations: 12     Fields:    Translation:AnimalsCells
  130. Hermes JD, Blacklow SC, Knowles JR. Searching sequence space by definably random mutagenesis: improving the catalytic potency of an enzyme. Proc Natl Acad Sci U S A. 1990 Jan; 87(2):696-700. PMID: 1967829.
    Citations: 24     Fields:    Translation:Cells
  131. Hermes JD, Parekh SM, Blacklow SC, Köster H, Knowles JR. A reliable method for random mutagenesis: the generation of mutant libraries using spiked oligodeoxyribonucleotide primers. Gene. 1989 Dec 07; 84(1):143-51. PMID: 2691332.
    Citations: 22     Fields:    Translation:Cells
  132. Blacklow SC, Raines RT, Lim WA, Zamore PD, Knowles JR. Triosephosphate isomerase catalysis is diffusion controlled. Appendix: Analysis of triose phosphate equilibria in aqueous solution by 31P NMR. Biochemistry. 1988 Feb 23; 27(4):1158-67. PMID: 3365378.
    Citations: 50     Fields:    Translation:AnimalsCells
  133. Hermes JD, Blacklow SC, Knowles JR. The development of enzyme catalytic efficiency: an experimental approach. Cold Spring Harb Symp Quant Biol. 1987; 52:597-602. PMID: 3454280.
    Citations: 4     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.