Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Lance Leon Munn, Ph.D.

Co-Author

This page shows the publications co-authored by Lance Munn and Rakesh Jain.
Connection Strength

12.654
  1. Vascular Normalization to Improve Treatment of COVID-19: Lessons from Treatment of Cancer. Clin Cancer Res. 2021 05 15; 27(10):2706-2711.
    View in: PubMed
    Score: 0.972
  2. Vascular regulation of antitumor immunity. Science. 2019 Aug 09; 365(6453):544-545.
    View in: PubMed
    Score: 0.873
  3. Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model. Cancer Res. 2007 Mar 15; 67(6):2729-35.
    View in: PubMed
    Score: 0.369
  4. Comparing machine learning algorithms for predicting ICU admission and mortality in COVID-19. NPJ Digit Med. 2021 May 21; 4(1):87.
    View in: PubMed
    Score: 0.247
  5. In silico dynamics of COVID-19 phenotypes for optimizing clinical management. Proc Natl Acad Sci U S A. 2021 01 19; 118(3).
    View in: PubMed
    Score: 0.241
  6. Physical traits of cancer. Science. 2020 10 30; 370(6516).
    View in: PubMed
    Score: 0.238
  7. In silico dynamics of COVID-19 phenotypes for optimizing clinical management. Res Sq. 2020 Sep 03.
    View in: PubMed
    Score: 0.235
  8. In vivo compression and imaging in mouse brain to measure the effects of solid stress. Nat Protoc. 2020 08; 15(8):2321-2340.
    View in: PubMed
    Score: 0.233
  9. Combining microenvironment normalization strategies to improve cancer immunotherapy. Proc Natl Acad Sci U S A. 2020 02 18; 117(7):3728-3737.
    View in: PubMed
    Score: 0.226
  10. Leaky vessels? Call Ang1! Nat Med. 2000 Feb; 6(2):131-2.
    View in: PubMed
    Score: 0.226
  11. Experimental and computational analyses reveal dynamics of tumor vessel cooption and optimal treatment strategies. Proc Natl Acad Sci U S A. 2019 02 12; 116(7):2662-2671.
    View in: PubMed
    Score: 0.210
  12. Mapping Physical Tumor Microenvironment and Drug Delivery. Clin Cancer Res. 2019 04 01; 25(7):2024-2026.
    View in: PubMed
    Score: 0.210
  13. Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium. Nat Biomed Eng. 2019 03; 3(3):230-245.
    View in: PubMed
    Score: 0.210
  14. Quantifying solid stress and elastic energy from excised or in situ tumors. Nat Protoc. 2018 05; 13(5):1091-1105.
    View in: PubMed
    Score: 0.199
  15. Reengineering the Tumor Vasculature: Improving Drug Delivery and Efficacy. Trends Cancer. 2018 04; 4(4):258-259.
    View in: PubMed
    Score: 0.198
  16. Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside. Trends Cancer. 2018 04; 4(4):292-319.
    View in: PubMed
    Score: 0.198
  17. Solid stress and elastic energy as measures of tumour mechanopathology. Nat Biomed Eng. 2016; 1.
    View in: PubMed
    Score: 0.181
  18. Role of erythrocytes in leukocyte-endothelial interactions: mathematical model and experimental validation. Biophys J. 1996 Jul; 71(1):466-78.
    View in: PubMed
    Score: 0.176
  19. Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival. Proc Natl Acad Sci U S A. 2016 Apr 19; 113(16):4476-81.
    View in: PubMed
    Score: 0.173
  20. Analysis of cell flux in the parallel plate flow chamber: implications for cell capture studies. Biophys J. 1994 Aug; 67(2):889-95.
    View in: PubMed
    Score: 0.154
  21. Compression of pancreatic tumor blood vessels by hyaluronan is caused by solid stress and not interstitial fluid pressure. Cancer Cell. 2014 Jul 14; 26(1):14-5.
    View in: PubMed
    Score: 0.154
  22. Measuring interstitial pH and pO2 in mouse tumors. Cold Spring Harb Protoc. 2013 Jul 01; 2013(7):675-7.
    View in: PubMed
    Score: 0.143
  23. Measuring interstitial diffusion, convection, and binding parameters in mouse tumors. Cold Spring Harb Protoc. 2013 Jul 01; 2013(7):678-80.
    View in: PubMed
    Score: 0.143
  24. Measuring leukocyte-endothelial interactions in mice. Cold Spring Harb Protoc. 2013 Jun 01; 2013(6):561-3.
    View in: PubMed
    Score: 0.142
  25. Can we identify predictive biomarkers for antiangiogenic therapy of cancer using mathematical modeling? J Natl Cancer Inst. 2013 Jun 05; 105(11):762-5.
    View in: PubMed
    Score: 0.142
  26. Measuring vascular permeability in mice. Cold Spring Harb Protoc. 2013 May 01; 2013(5):444-6.
    View in: PubMed
    Score: 0.141
  27. Measuring angiogenesis and hemodynamics in mice. Cold Spring Harb Protoc. 2013 Apr 01; 2013(4):354-8.
    View in: PubMed
    Score: 0.140
  28. Lung window preparation in mice. Cold Spring Harb Protoc. 2013 Jan 01; 2013(1).
    View in: PubMed
    Score: 0.138
  29. Pancreatic tumor preparation in mice. Cold Spring Harb Protoc. 2012 Dec 01; 2012(12).
    View in: PubMed
    Score: 0.137
  30. Liver tumor preparation in mice. Cold Spring Harb Protoc. 2012 Dec 01; 2012(12).
    View in: PubMed
    Score: 0.137
  31. Lymphangiography of the mouse tail. Cold Spring Harb Protoc. 2012 Nov 01; 2012(11):1177-8.
    View in: PubMed
    Score: 0.136
  32. Lymphangiography of the mouse ear. Cold Spring Harb Protoc. 2012 Nov 01; 2012(11):1179-80.
    View in: PubMed
    Score: 0.136
  33. Mammary fat pad chamber preparation in mice. Cold Spring Harb Protoc. 2012 Oct 01; 2012(10):1113-4.
    View in: PubMed
    Score: 0.136
  34. Mammary fat pad tumor preparation in mice. Cold Spring Harb Protoc. 2012 Oct 01; 2012(10):1115-6.
    View in: PubMed
    Score: 0.136
  35. Corneal pocket assay in rabbits. Cold Spring Harb Protoc. 2012 Sep 01; 2012(9):1017-8.
    View in: PubMed
    Score: 0.135
  36. Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15101-8.
    View in: PubMed
    Score: 0.135
  37. Rabbit ear chambers. Cold Spring Harb Protoc. 2012 Jul 01; 2012(7):813-14.
    View in: PubMed
    Score: 0.133
  38. Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors? J Natl Cancer Inst. 2012 Jun 20; 104(12):899-905.
    View in: PubMed
    Score: 0.132
  39. Video-rate resonant scanning multiphoton microscopy: An emerging technique for intravital imaging of the tumor microenvironment. Intravital. 2012; 1(1).
    View in: PubMed
    Score: 0.129
  40. Mechanical compression drives cancer cells toward invasive phenotype. Proc Natl Acad Sci U S A. 2012 Jan 17; 109(3):911-6.
    View in: PubMed
    Score: 0.129
  41. Engineered blood vessel networks connect to host vasculature via wrapping-and-tapping anastomosis. Blood. 2011 Oct 27; 118(17):4740-9.
    View in: PubMed
    Score: 0.125
  42. Normalization of the vasculature for treatment of cancer and other diseases. Physiol Rev. 2011 Jul; 91(3):1071-121.
    View in: PubMed
    Score: 0.124
  43. Is vasculogenesis crucial for the regrowth of irradiated tumours? Nat Rev Cancer. 2011 Jun 24; 11(7):532.
    View in: PubMed
    Score: 0.124
  44. Scaling rules for diffusive drug delivery in tumor and normal tissues. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1799-803.
    View in: PubMed
    Score: 0.120
  45. Diffusion anisotropy in collagen gels and tumors: the effect of fiber network orientation. Biophys J. 2010 Nov 17; 99(10):3119-28.
    View in: PubMed
    Score: 0.119
  46. Diffusion of particles in the extracellular matrix: the effect of repulsive electrostatic interactions. Biophys J. 2010 Sep 08; 99(5):1342-9.
    View in: PubMed
    Score: 0.118
  47. In vivo imaging of tumors. Cold Spring Harb Protoc. 2010 Jul 01; 2010(7):pdb.prot5452.
    View in: PubMed
    Score: 0.116
  48. Simultaneous measurement of RBC velocity, flux, hematocrit and shear rate in vascular networks. Nat Methods. 2010 Aug; 7(8):655-60.
    View in: PubMed
    Score: 0.116
  49. Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation. 2010 Apr; 17(3):206-25.
    View in: PubMed
    Score: 0.114
  50. Paradoxical effects of PDGF-BB overexpression in endothelial cells on engineered blood vessels in vivo. Am J Pathol. 2009 Jul; 175(1):294-302.
    View in: PubMed
    Score: 0.108
  51. PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment. PLoS One. 2009; 4(4):e5123.
    View in: PubMed
    Score: 0.107
  52. Edema control by cediranib, a vascular endothelial growth factor receptor-targeted kinase inhibitor, prolongs survival despite persistent brain tumor growth in mice. J Clin Oncol. 2009 May 20; 27(15):2542-52.
    View in: PubMed
    Score: 0.106
  53. Micro-environmental mechanical stress controls tumor spheroid size and morphology by suppressing proliferation and inducing apoptosis in cancer cells. PLoS One. 2009; 4(2):e4632.
    View in: PubMed
    Score: 0.106
  54. Non-uniform plasma leakage affects local hematocrit and blood flow: implications for inflammation and tumor perfusion. Ann Biomed Eng. 2007 Dec; 35(12):2121-9.
    View in: PubMed
    Score: 0.096
  55. Active versus passive mechanisms in metastasis: do cancer cells crawl into vessels, or are they pushed? Lancet Oncol. 2007 May; 8(5):444-8.
    View in: PubMed
    Score: 0.093
  56. Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers. Cancer Res. 2005 Jul 01; 65(13):5740-9.
    View in: PubMed
    Score: 0.082
  57. Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: role of oxygenation, angiopoietin-1, and matrix metalloproteinases. Cancer Cell. 2004 Dec; 6(6):553-63.
    View in: PubMed
    Score: 0.079
  58. Differential transplantability of tumor-associated stromal cells. Cancer Res. 2004 Sep 01; 64(17):5920-4.
    View in: PubMed
    Score: 0.077
  59. Differential gene expression in metastasizing cells shed from kidney tumors. Cancer Res. 2004 Apr 01; 64(7):2469-73.
    View in: PubMed
    Score: 0.075
  60. Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med. 2004 Feb; 10(2):145-7.
    View in: PubMed
    Score: 0.074
  61. Solid stress generated by spheroid growth estimated using a linear poroelasticity model. Microvasc Res. 2003 Nov; 66(3):204-12.
    View in: PubMed
    Score: 0.073
  62. Sparse initial entrapment of systemically injected Salmonella typhimurium leads to heterogeneous accumulation within tumors. Cancer Res. 2003 Sep 01; 63(17):5188-93.
    View in: PubMed
    Score: 0.072
  63. A mathematical model of the contribution of endothelial progenitor cells to angiogenesis in tumors: implications for antiangiogenic therapy. Blood. 2003 Oct 01; 102(7):2555-61.
    View in: PubMed
    Score: 0.071
  64. Cationic charge determines the distribution of liposomes between the vascular and extravascular compartments of tumors. Cancer Res. 2002 Dec 01; 62(23):6831-6.
    View in: PubMed
    Score: 0.069
  65. Red blood cells augment leukocyte rolling in a virtual blood vessel. Biophys J. 2002 Oct; 83(4):1834-41.
    View in: PubMed
    Score: 0.068
  66. Antibody-directed effector cell therapy of tumors: analysis and optimization using a physiologically based pharmacokinetic model. Neoplasia. 2002 Sep-Oct; 4(5):449-63.
    View in: PubMed
    Score: 0.067
  67. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science. 2002 Jun 07; 296(5574):1883-6.
    View in: PubMed
    Score: 0.066
  68. Dissecting tumour pathophysiology using intravital microscopy. Nat Rev Cancer. 2002 Apr; 2(4):266-76.
    View in: PubMed
    Score: 0.066
  69. Solid stress facilitates spheroid formation: potential involvement of hyaluronan. Br J Cancer. 2002 Mar 18; 86(6):947-53.
    View in: PubMed
    Score: 0.065
  70. Systemic distribution and tumor localization of adoptively transferred lymphocytes in mice: comparison with physiologically based pharmacokinetic model. Neoplasia. 2002 Jan-Feb; 4(1):3-8.
    View in: PubMed
    Score: 0.064
  71. Vascular morphogenesis and remodeling in a human tumor xenograft: blood vessel formation and growth after ovariectomy and tumor implantation. Circ Res. 2001 Oct 12; 89(8):732-9.
    View in: PubMed
    Score: 0.063
  72. Kinetics of placenta growth factor/vascular endothelial growth factor synergy in endothelial hydraulic conductivity and proliferation. Microvasc Res. 2001 Mar; 61(2):203-10.
    View in: PubMed
    Score: 0.061
  73. Lateral view flow system for studies of cell adhesion and deformation under flow conditions. Biotechniques. 2001 Feb; 30(2):388-94.
    View in: PubMed
    Score: 0.060
  74. Placental growth factor promotes tumour desmoplasia and treatment resistance in intrahepatic cholangiocarcinoma. Gut. 2021 Jan 11.
    View in: PubMed
    Score: 0.060
  75. Modulation of A-NK cell rigidity: In vitro characterization and in vivo implications for cell delivery. Biorheology. 2001; 38(2-3):151-9.
    View in: PubMed
    Score: 0.060
  76. Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood. Proc Natl Acad Sci U S A. 2000 Dec 19; 97(26):14608-13.
    View in: PubMed
    Score: 0.060
  77. Regorafenib combined with PD1 blockade increases CD8 T-cell infiltration by inducing CXCL10 expression in hepatocellular carcinoma. J Immunother Cancer. 2020 11; 8(2).
    View in: PubMed
    Score: 0.059
  78. Erythrocytes enhance lymphocyte rolling and arrest in vivo. Microvasc Res. 2000 Mar; 59(2):316-22.
    View in: PubMed
    Score: 0.057
  79. Vasculogenic mimicry: how convincing, how novel, and how significant? Am J Pathol. 2000 Feb; 156(2):383-8.
    View in: PubMed
    Score: 0.056
  80. Effect of local anti-VEGF antibody treatment on tumor microvessel permeability. Microvasc Res. 1999 May; 57(3):357-62.
    View in: PubMed
    Score: 0.054
  81. In vitro and in vivo quantification of adhesion between leukocytes and vascular endothelium. Methods Mol Med. 1999; 18:553-75.
    View in: PubMed
    Score: 0.052
  82. Consensus guidelines for the use and interpretation of angiogenesis assays. Angiogenesis. 2018 08; 21(3):425-532.
    View in: PubMed
    Score: 0.051
  83. Secretory leukocyte protease inhibitor (SLPI) as a potential target for inhibiting metastasis of triple-negative breast cancers. Oncotarget. 2017 Dec 12; 8(65):108292-108302.
    View in: PubMed
    Score: 0.048
  84. Stress granule-associated protein G3BP2 regulates breast tumor initiation. Proc Natl Acad Sci U S A. 2017 01 31; 114(5):1033-1038.
    View in: PubMed
    Score: 0.046
  85. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nat Med. 1996 Sep; 2(9):992-7.
    View in: PubMed
    Score: 0.045
  86. Leukocyte-endothelial adhesion and angiogenesis in tumors. Cancer Metastasis Rev. 1996 Jun; 15(2):195-204.
    View in: PubMed
    Score: 0.044
  87. Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis. Microvasc Res. 1996 Mar; 51(2):260-72.
    View in: PubMed
    Score: 0.043
  88. Adhesion of activated natural killer cells to tumor necrosis factor-alpha-treated endothelium under physiological flow conditions. Nat Immun. 1996-1997; 15(2-3):154-63.
    View in: PubMed
    Score: 0.042
  89. Selectin- and integrin-mediated T-lymphocyte rolling and arrest on TNF-alpha-activated endothelium: augmentation by erythrocytes. Biophys J. 1995 Nov; 69(5):2131-8.
    View in: PubMed
    Score: 0.042
  90. Kinetics of adhesion molecule expression and spatial organization using targeted sampling fluorometry. Biotechniques. 1995 Oct; 19(4):622-6, 628-31.
    View in: PubMed
    Score: 0.042
  91. Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17561-6.
    View in: PubMed
    Score: 0.034
  92. Impaired lymphatic contraction associated with immunosuppression. Proc Natl Acad Sci U S A. 2011 Nov 15; 108(46):18784-9.
    View in: PubMed
    Score: 0.032
  93. Cancer cell-associated MT1-MMP promotes blood vessel invasion and distant metastasis in triple-negative mammary tumors. Cancer Res. 2011 Jul 01; 71(13):4527-38.
    View in: PubMed
    Score: 0.031
  94. Angiopoietin-2 interferes with anti-VEGFR2-induced vessel normalization and survival benefit in mice bearing gliomas. Clin Cancer Res. 2010 Jul 15; 16(14):3618-27.
    View in: PubMed
    Score: 0.029
  95. Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging. Nat Med. 2009 Oct; 15(10):1219-23.
    View in: PubMed
    Score: 0.027
  96. In vivo imaging of extracellular matrix remodeling by tumor-associated fibroblasts. Nat Methods. 2009 Feb; 6(2):143-5.
    View in: PubMed
    Score: 0.026
  97. A protocol for phenotypic detection and characterization of vascular cells of different origins in a lung neovascularization model in rodents. Nat Protoc. 2008; 3(3):388-97.
    View in: PubMed
    Score: 0.024
  98. Surrogate markers for antiangiogenic therapy and dose-limiting toxicities for bevacizumab with radiation and chemotherapy: continued experience of a phase I trial in rectal cancer patients. J Clin Oncol. 2005 Nov 01; 23(31):8136-9.
    View in: PubMed
    Score: 0.021
  99. Lack of telopeptides in fibrillar collagen I promotes the invasion of a metastatic breast tumor cell line. Cancer Res. 2005 Jul 01; 65(13):5674-82.
    View in: PubMed
    Score: 0.021
  100. NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. J Clin Invest. 2005 Jul; 115(7):1816-27.
    View in: PubMed
    Score: 0.020
  101. Vascular morphogenesis and remodeling in a model of tissue repair: blood vessel formation and growth in the ovarian pedicle after ovariectomy. Circ Res. 2001 Oct 12; 89(8):723-31.
    View in: PubMed
    Score: 0.016
  102. Decorin inhibits endothelial migration and tube-like structure formation: role of thrombospondin-1. Microvasc Res. 2001 Jul; 62(1):26-42.
    View in: PubMed
    Score: 0.016
  103. Effect of vascular endothelial growth factor on cultured endothelial cell monolayer transport properties. Microvasc Res. 2000 Mar; 59(2):265-77.
    View in: PubMed
    Score: 0.014
  104. Early events of metastasis in the microcirculation involve changes in gene expression of cancer cells. Tracking mRNA levels of metastasizing cancer cells in the chick embryo chorioallantoic membrane. Am J Pathol. 1997 Jun; 150(6):2099-112.
    View in: PubMed
    Score: 0.012
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.