Harvard Catalyst Profiles

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Charles Dean Stiles, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. P50CA165962 (BATCHELOR, TRACY T) Sep 19, 2013 - Jul 31, 2018
    NIH/NCI
    SPORE: Targeted Therapies for Glioma
    Role: Co-Principal Investigator
  2. P01CA142536 (SEGAL, ROSALIND A.) Feb 16, 2011 - Jan 31, 2016
    NIH/NCI
    Therapeutic Opportunities for Pediatric Astrocytoma
    Role: Co-Principal Investigator
  3. R01NS057727 (STILES, CHARLES D) Dec 1, 2006 - May 31, 2016
    NIH/NINDS
    OLIG2 Phosphorylation as a Drug Target for Glioma
    Role: Principal Investigator
  4. P01NS047572 (STILES, CHARLES) Dec 1, 2003 - Aug 31, 2014
    NIH/NINDS
    Molecular Mechanisms of Fate Choice in Neural Stem Cells (P01)
    Role: Principal Investigator
  5. R03CA102974 (STILES, CHARLES) Jul 10, 2003 - Jun 30, 2005
    NIH/NCI
    Small Molecule Kinase Inhibitor for Malignant Glioma
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ramkissoon SH, Bandopadhayay P, Hwang J, Ramkissoon LA, Greenwald NF, Schumacher SE, O'Rourke R, Pinches N, Ho P, Malkin H, Sinai C, Filbin M, Plant A, Bi WL, Chang MS, Yang E, Wright KD, Manley PE, Ducar M, Alexandrescu S, Lidov H, Delalle I, Goumnerova LC, Church AJ, Janeway KA, Harris MH, MacConaill LE, Folkerth RD, Lindeman NI, Stiles CD, Kieran MW, Ligon AH, Santagata S, Dubuc AM, Chi SN, Beroukhim R, Ligon KL. Clinical targeted exome-based sequencing in combination with genome-wide copy number profiling: precision medicine analysis of 203 pediatric brain tumors. Neuro Oncol. 2017 Jul 01; 19(7):986-996. PMID: 28104717.
    Citations: 5     Fields:    Translation:Humans
  2. Sun Y, Alberta JA, Pilarz C, Calligaris D, Chadwick EJ, Ramkissoon SH, Ramkissoon LA, Garcia VM, Mazzola E, Goumnerova L, Kane M, Yao Z, Kieran MW, Ligon KL, Hahn WC, Garraway LA, Rosen N, Gray NS, Agar NY, Buhrlage SJ, Segal RA, Stiles CD. A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas. Neuro Oncol. 2017 06 01; 19(6):774-785. PMID: 28082416.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  3. Bandopadhayay P, Stiles CD. Population Control: Cortical Interneurons Modulate Oligodendrogenesis. Neuron. 2017 May 03; 94(3):415-417. PMID: 28472644.
    Citations:    Fields:    Translation:Cells
  4. Zhou J, Tien AC, Alberta JA, Ficarro SB, Griveau A, Sun Y, Deshpande JS, Card JD, Morgan-Smith M, Michowski W, Hashizume R, James CD, Ligon KL, Snider WD, Sicinski P, Marto JA, Rowitch DH, Stiles CD. A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2. Cell Rep. 2017 03 28; 18(13):3167-3177. PMID: 28355568.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  5. Selt F, Hohloch J, Hielscher T, Sahm F, Capper D, Korshunov A, Usta D, Brabetz S, Ridinger J, Ecker J, Oehme I, Gronych J, Marquardt V, Pauck D, Bächli H, Stiles CD, von Deimling A, Remke M, Schuhmann MU, Pfister SM, Brummer T, Jones DT, Witt O, Milde T. Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing. Oncotarget. 2017 Feb 14; 8(7):11460-11479. PMID: 28002790.
    Citations: 4     Fields:    Translation:HumansCells
  6. Paolella BR, Gibson WJ, Urbanski LM, Alberta JA, Zack TI, Bandopadhayay P, Nichols CA, Agarwalla PK, Brown MS, Lamothe R, Yu Y, Choi PS, Obeng EA, Heckl D, Wei G, Wang B, Tsherniak A, Vazquez F, Weir BA, Root DE, Cowley GS, Buhrlage SJ, Stiles CD, Ebert BL, Hahn WC, Reed R, Beroukhim R. Copy-number and gene dependency analysis reveals partial copy loss of wild-type SF3B1 as a novel cancer vulnerability. Elife. 2017 02 08; 6. PMID: 28177281.
    Citations: 5     Fields:    Translation:HumansCells
  7. Edwards AL, Meijer DH, Guerra RM, Molenaar RJ, Alberta JA, Bernal F, Bird GH, Stiles CD, Walensky LD. Challenges in Targeting a Basic Helix-Loop-Helix Transcription Factor with Hydrocarbon-Stapled Peptides. ACS Chem Biol. 2016 11 18; 11(11):3146-3153. PMID: 27643505.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Ni J, Xie S, Ramkissoon SH, Luu V, Sun Y, Bandopadhayay P, Beroukhim R, Roberts TM, Stiles CD, Segal RA, Ligon KL, Hahn WC, Zhao JJ. Tyrosine receptor kinase B is a drug target in astrocytomas. Neuro Oncol. 2017 01; 19(1):22-30. PMID: 27402815.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  9. Paolella BR, Stiles CD. Gliomas "Dope Up" for Growth. Cancer Cell. 2016 06 13; 29(6):778-780. PMID: 27300432.
    Citations:    Fields:    Translation:HumansCells
  10. Bandopadhayay P, Ramkissoon LA, Jain P, Bergthold G, Wala J, Zeid R, Schumacher SE, Urbanski L, O'Rourke R, Gibson WJ, Pelton K, Ramkissoon SH, Han HJ, Zhu Y, Choudhari N, Silva A, Boucher K, Henn RE, Kang YJ, Knoff D, Paolella BR, Gladden-Young A, Varlet P, Pages M, Horowitz PM, Federation A, Malkin H, Tracy AA, Seepo S, Ducar M, Van Hummelen P, Santi M, Buccoliero AM, Scagnet M, Bowers DC, Giannini C, Puget S, Hawkins C, Tabori U, Klekner A, Bognar L, Burger PC, Eberhart C, Rodriguez FJ, Hill DA, Mueller S, Haas-Kogan DA, Phillips JJ, Santagata S, Stiles CD, Bradner JE, Jabado N, Goren A, Grill J, Ligon AH, Goumnerova L, Waanders AJ, Storm PB, Kieran MW, Ligon KL, Beroukhim R, Resnick AC. MYB-QKI rearrangements in angiocentric glioma drive tumorigenicity through a tripartite mechanism. Nat Genet. 2016 Mar; 48(3):273-82. PMID: 26829751.
    Citations: 36     Fields:    Translation:HumansCells
  11. Chadwick EJ, Yang DP, Filbin MG, Mazzola E, Sun Y, Behar O, Pazyra-Murphy MF, Goumnerova L, Ligon KL, Stiles CD, Segal RA. A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies. J Vis Exp. 2015 Nov 07; (105):e53304. PMID: 26575352.
    Citations: 6     Fields:    Translation:Animals
  12. Filbin MG, Stiles CD. Of Brains and Blood: Developmental Origins of Glioma Diversity? Cancer Cell. 2015 Oct 12; 28(4):403-404. PMID: 26461085.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  13. Bergthold G, Bandopadhayay P, Hoshida Y, Ramkissoon S, Ramkissoon L, Rich B, Maire CL, Paolella BR, Schumacher SE, Tabak B, Ferrer-Luna R, Ozek M, Sav A, Santagata S, Wen PY, Goumnerova LC, Ligon AH, Stiles C, Segal R, Golub T, Grill J, Ligon KL, Chan JA, Kieran MW, Beroukhim R. Expression profiles of 151 pediatric low-grade gliomas reveal molecular differences associated with location and histological subtype. Neuro Oncol. 2015 Nov; 17(11):1486-96. PMID: 25825052.
    Citations: 9     Fields:    Translation:HumansCells
  14. Meijer DH, Sun Y, Liu T, Kane MF, Alberta JA, Adelmant G, Kupp R, Marto JA, Rowitch DH, Nakatani Y, Stiles CD, Mehta S. An amino terminal phosphorylation motif regulates intranuclear compartmentalization of Olig2 in neural progenitor cells. J Neurosci. 2014 Jun 18; 34(25):8507-18. PMID: 24948806.
    Citations: 6     Fields:    Translation:AnimalsCells
  15. Bergthold G, Bandopadhayay P, Bi WL, Ramkissoon L, Stiles C, Segal RA, Beroukhim R, Ligon KL, Grill J, Kieran MW. Pediatric low-grade gliomas: how modern biology reshapes the clinical field. Biochim Biophys Acta. 2014 Apr; 1845(2):294-307. PMID: 24589977.
    Citations: 13     Fields:    Translation:Humans
  16. Silbereis JC, Nobuta H, Tsai HH, Heine VM, McKinsey GL, Meijer DH, Howard MA, Petryniak MA, Potter GB, Alberta JA, Baraban SC, Stiles CD, Rubenstein JL, Rowitch DH. Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain. Neuron. 2014 Feb 05; 81(3):574-87. PMID: 24507192.
    Citations: 19     Fields:    Translation:AnimalsCells
  17. Pak E, Segal RA, Stiles CD. New progenitors NESTIN(g) in the EGL. Nat Neurosci. 2013 Dec; 16(12):1710-2. PMID: 24270268.
    Citations:    Fields:    Translation:HumansAnimalsCells
  18. Liu X, Ide JL, Norton I, Marchionni MA, Ebling MC, Wang LY, Davis E, Sauvageot CM, Kesari S, Kellersberger KA, Easterling ML, Santagata S, Stuart DD, Alberta J, Agar JN, Stiles CD, Agar NY. Molecular imaging of drug transit through the blood-brain barrier with MALDI mass spectrometry imaging. Sci Rep. 2013 Oct 04; 3:2859. PMID: 24091529.
    Citations: 33     Fields:    Translation:HumansAnimals
  19. Ramkissoon LA, Horowitz PM, Craig JM, Ramkissoon SH, Rich BE, Schumacher SE, McKenna A, Lawrence MS, Bergthold G, Brastianos PK, Tabak B, Ducar MD, Van Hummelen P, MacConaill LE, Pouissant-Young T, Cho YJ, Taha H, Mahmoud M, Bowers DC, Margraf L, Tabori U, Hawkins C, Packer RJ, Hill DA, Pomeroy SL, Eberhart CG, Dunn IF, Goumnerova L, Getz G, Chan JA, Santagata S, Hahn WC, Stiles CD, Ligon AH, Kieran MW, Beroukhim R, Ligon KL. Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8188-93. PMID: 23633565.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  20. Meijer DH, Kane MF, Mehta S, Liu H, Harrington E, Taylor CM, Stiles CD, Rowitch DH. Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2. Nat Rev Neurosci. 2012 Dec; 13(12):819-31. PMID: 23165259.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  21. Zhou J, Stiles CD. Asleep at the switch: MEK kinases control transit to gliogenesis in developing cortex. Neuron. 2012 Sep 20; 75(6):940-2. PMID: 22998861.
    Citations:    Fields:    Translation:AnimalsCells
  22. Chi AS, Batchelor TT, Dias-Santagata D, Borger D, Stiles CD, Wang DL, Curry WT, Wen PY, Ligon KL, Ellisen L, Louis DN, Iafrate AJ. Prospective, high-throughput molecular profiling of human gliomas. J Neurooncol. 2012 Oct; 110(1):89-98. PMID: 22821383.
    Citations: 17     Fields:    Translation:Humans
  23. Yu J, Valerius MT, Duah M, Staser K, Hansard JK, Guo JJ, McMahon J, Vaughan J, Faria D, Georgas K, Rumballe B, Ren Q, Krautzberger AM, Junker JP, Thiagarajan RD, Machanick P, Gray PA, van Oudenaarden A, Rowitch DH, Stiles CD, Ma Q, Grimmond SM, Bailey TL, Little MH, McMahon AP. Identification of molecular compartments and genetic circuitry in the developing mammalian kidney. Development. 2012 May; 139(10):1863-73. PMID: 22510988.
    Citations: 25     Fields:    Translation:Animals
  24. Tian Y, Rich BE, Vena N, Craig JM, Macconaill LE, Rajaram V, Goldman S, Taha H, Mahmoud M, Ozek M, Sav A, Longtine JA, Lindeman NI, Garraway LA, Ligon AH, Stiles CD, Santagata S, Chan JA, Kieran MW, Ligon KL. Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas. J Mol Diagn. 2011 Nov; 13(6):669-77. PMID: 21884820.
    Citations: 23     Fields:    Translation:Humans
  25. Gutmann DH, Stiles CD, Lowe SW, Bollag GE, Furnari FB, Charest AL. Report from the fifth National Cancer Institute Mouse Models of Human Cancers Consortium Nervous System Tumors Workshop. Neuro Oncol. 2011 Jul; 13(7):692-9. PMID: 21727208.
    Citations: 4     Fields:    Translation:HumansAnimals
  26. Sun Y, Meijer DH, Alberta JA, Mehta S, Kane MF, Tien AC, Fu H, Petryniak MA, Potter GB, Liu Z, Powers JF, Runquist IS, Rowitch DH, Stiles CD. Phosphorylation state of Olig2 regulates proliferation of neural progenitors. Neuron. 2011 Mar 10; 69(5):906-17. PMID: 21382551.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  27. Mehta S, Huillard E, Kesari S, Maire CL, Golebiowski D, Harrington EP, Alberta JA, Kane MF, Theisen M, Ligon KL, Rowitch DH, Stiles CD. The central nervous system-restricted transcription factor Olig2 opposes p53 responses to genotoxic damage in neural progenitors and malignant glioma. Cancer Cell. 2011 Mar 08; 19(3):359-71. PMID: 21397859.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  28. Chaponis D, Barnes JW, Dellagatta JL, Kesari S, Fast E, Sauvageot C, Panagrahy D, Greene ER, Ramakrishna N, Wen PY, Kung AL, Stiles C, Kieran MW. Lonafarnib (SCH66336) improves the activity of temozolomide and radiation for orthotopic malignant gliomas. J Neurooncol. 2011 Aug; 104(1):179-89. PMID: 21246394.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  29. Qin Y, Yao L, King EE, Buddavarapu K, Lenci RE, Chocron ES, Lechleiter JD, Sass M, Aronin N, Schiavi F, Boaretto F, Opocher G, Toledo RA, Toledo SP, Stiles C, Aguiar RC, Dahia PL. Germline mutations in TMEM127 confer susceptibility to pheochromocytoma. Nat Genet. 2010 Mar; 42(3):229-33. PMID: 20154675.
    Citations: 115     Fields:    Translation:HumansCells
  30. Wen PY, Yung WK, Lamborn KR, Norden AD, Cloughesy TF, Abrey LE, Fine HA, Chang SM, Robins HI, Fink K, Deangelis LM, Mehta M, Di Tomaso E, Drappatz J, Kesari S, Ligon KL, Aldape K, Jain RK, Stiles CD, Egorin MJ, Prados MD. Phase II study of imatinib mesylate for recurrent meningiomas (North American Brain Tumor Consortium study 01-08). Neuro Oncol. 2009 Dec; 11(6):853-60. PMID: 19293394.
    Citations: 39     Fields:    Translation:HumansCTClinical Trials
  31. MacConaill LE, Campbell CD, Kehoe SM, Bass AJ, Hatton C, Niu L, Davis M, Yao K, Hanna M, Mondal C, Luongo L, Emery CM, Baker AC, Philips J, Goff DJ, Fiorentino M, Rubin MA, Polyak K, Chan J, Wang Y, Fletcher JA, Santagata S, Corso G, Roviello F, Shivdasani R, Kieran MW, Ligon KL, Stiles CD, Hahn WC, Meyerson ML, Garraway LA. Profiling critical cancer gene mutations in clinical tumor samples. PLoS One. 2009 Nov 18; 4(11):e7887. PMID: 19924296.
    Citations: 162     Fields:    Translation:Humans
  32. Fu H, Cai J, Clevers H, Fast E, Gray S, Greenberg R, Jain MK, Ma Q, Qiu M, Rowitch DH, Taylor CM, Stiles CD. A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial development. J Neurosci. 2009 Sep 09; 29(36):11399-408. PMID: 19741146.
    Citations: 50     Fields:    Translation:AnimalsCells
  33. Sauvageot CM, Weatherbee JL, Kesari S, Winters SE, Barnes J, Dellagatta J, Ramakrishna NR, Stiles CD, Kung AL, Kieran MW, Wen PY. Efficacy of the HSP90 inhibitor 17-AAG in human glioma cell lines and tumorigenic glioma stem cells. Neuro Oncol. 2009 Apr; 11(2):109-21. PMID: 18682579.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  34. Stiles CD, Rowitch DH. Glioma stem cells: a midterm exam. Neuron. 2008 Jun 26; 58(6):832-46. PMID: 18579075.
    Citations: 127     Fields:    Translation:HumansAnimalsCells
  35. Sauvageot CM, Kesari S, Stiles CD. Molecular pathogenesis of adult brain tumors and the role of stem cells. Neurol Clin. 2007 Nov; 25(4):891-924, vii. PMID: 17964020.
    Citations: 17     Fields:    Translation:HumansCells
  36. Kesari S, Jackson-Grusby L, Stiles CD. "Smad"eningly erratic: target gene methylation determines whether TGFbeta promotes or suppresses malignant glioma. Dev Cell. 2007 Mar; 12(3):324-5. PMID: 17336898.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  37. Ligon KL, Huillard E, Mehta S, Kesari S, Liu H, Alberta JA, Bachoo RM, Kane M, Louis DN, Depinho RA, Anderson DJ, Stiles CD, Rowitch DH. Olig2-regulated lineage-restricted pathway controls replication competence in neural stem cells and malignant glioma. Neuron. 2007 Feb 15; 53(4):503-17. PMID: 17296553.
    Citations: 185     Fields:    Translation:AnimalsCells
  38. Wen PY, Yung WK, Lamborn KR, Dahia PL, Wang Y, Peng B, Abrey LE, Raizer J, Cloughesy TF, Fink K, Gilbert M, Chang S, Junck L, Schiff D, Lieberman F, Fine HA, Mehta M, Robins HI, DeAngelis LM, Groves MD, Puduvalli VK, Levin V, Conrad C, Maher EA, Aldape K, Hayes M, Letvak L, Egorin MJ, Capdeville R, Kaplan R, Murgo AJ, Stiles C, Prados MD. Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res. 2006 Aug 15; 12(16):4899-907. PMID: 16914578.
    Citations: 125     Fields:    Translation:HumansCTClinical Trials
  39. Kesari S, Stiles CD. The bad seed: PDGF receptors link adult neural progenitors to glioma stem cells. Neuron. 2006 Jul 20; 51(2):151-3. PMID: 16846849.
    Citations: 12     Fields:    Translation:HumansCells
  40. Ligon KL, Kesari S, Kitada M, Sun T, Arnett HA, Alberta JA, Anderson DJ, Stiles CD, Rowitch DH. Development of NG2 neural progenitor cells requires Olig gene function. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7853-8. PMID: 16682644.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  41. Sun T, Hafler BP, Kaing S, Kitada M, Ligon KL, Widlund HR, Yuk DI, Stiles CD, Rowitch DH. Evidence for motoneuron lineage-specific regulation of Olig2 in the vertebrate neural tube. Dev Biol. 2006 Apr 01; 292(1):152-64. PMID: 16469306.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  42. Kesari S, Ramakrishna N, Sauvageot C, Stiles CD, Wen PY. Targeted molecular therapy of malignant gliomas. Curr Oncol Rep. 2006 Jan; 8(1):58-70. PMID: 16464405.
    Citations: 11     Fields:    
  43. Dahia PL, Hao K, Rogus J, Colin C, Pujana MA, Ross K, Magoffin D, Aronin N, Cascon A, Hayashida CY, Li C, Toledo SP, Stiles CD. Novel pheochromocytoma susceptibility loci identified by integrative genomics. Cancer Res. 2005 Nov 01; 65(21):9651-8. PMID: 16266984.
    Citations: 26     Fields:    Translation:HumansCells
  44. Dahia PL, Ross KN, Wright ME, Hayashida CY, Santagata S, Barontini M, Kung AL, Sanso G, Powers JF, Tischler AS, Hodin R, Heitritter S, Moore F, Dluhy R, Sosa JA, Ocal IT, Benn DE, Marsh DJ, Robinson BG, Schneider K, Garber J, Arum SM, Korbonits M, Grossman A, Pigny P, Toledo SP, Nosé V, Li C, Stiles CD. A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet. 2005 Jul; 1(1):72-80. PMID: 16103922.
    Citations: 140     Fields:    
  45. McKee AE, Minet E, Stern C, Riahi S, Stiles CD, Silver PA. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. BMC Dev Biol. 2005 Jul 20; 5:14. PMID: 16033648.
    Citations: 68     Fields:    Translation:Animals
  46. Kesari S, Ramakrishna N, Sauvageot C, Stiles CD, Wen PY. Targeted molecular therapy of malignant gliomas. Curr Neurol Neurosci Rep. 2005 May; 5(3):186-97. PMID: 15865884.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  47. Sauvageot C, Dahia PL, Lipan O, Park JK, Chang MS, Alberta JA, Stiles CD. Distinct temporal genetic signatures of neurogenic and gliogenic cues in cortical stem cell cultures. J Neurobiol. 2005 Jan; 62(1):121-33. PMID: 15389679.
    Citations: 1     Fields:    Translation:AnimalsCells
  48. Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q. Mouse brain organization revealed through direct genome-scale TF expression analysis. Science. 2004 Dec 24; 306(5705):2255-7. PMID: 15618518.
    Citations: 182     Fields:    Translation:Animals
  49. Arnett HA, Fancy SP, Alberta JA, Zhao C, Plant SR, Kaing S, Raine CS, Rowitch DH, Franklin RJ, Stiles CD. bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS. Science. 2004 Dec 17; 306(5704):2111-5. PMID: 15604411.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  50. Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD, Rowitch DH. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropathol Exp Neurol. 2004 May; 63(5):499-509. PMID: 15198128.
    Citations: 126     Fields:    Translation:HumansAnimalsCells
  51. Bithell A, Alberta J, Hornby F, Stiles CD, Williams BP. Expression of the guanine nucleotide exchange factor, mr-gef, is regulated during the differentiation of specific subsets of telencephalic neurons. Brain Res Dev Brain Res. 2003 Dec 19; 146(1-2):107-18. PMID: 14643017.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  52. Stiles CD. Lost in space: misregulated positional cues create tripotent neural progenitors in cell culture. Neuron. 2003 Oct 30; 40(3):447-9. PMID: 14642266.
    Citations: 2     Fields:    Translation:AnimalsCells
  53. Sun T, Dong H, Wu L, Kane M, Rowitch DH, Stiles CD. Cross-repressive interaction of the Olig2 and Nkx2.2 transcription factors in developing neural tube associated with formation of a specific physical complex. J Neurosci. 2003 Oct 22; 23(29):9547-56. PMID: 14573534.
    Citations: 24     Fields:    Translation:AnimalsCells
  54. Ross SE, Greenberg ME, Stiles CD. Basic helix-loop-helix factors in cortical development. Neuron. 2003 Jul 03; 39(1):13-25. PMID: 12848929.
    Citations: 172     Fields:    Translation:HumansAnimalsCells
  55. Bhattacharyya A, Watson FL, Pomeroy SL, Zhang YZ, Stiles CD, Segal RA. High-resolution imaging demonstrates dynein-based vesicular transport of activated Trk receptors. J Neurobiol. 2002 Jun 15; 51(4):302-12. PMID: 12150505.
    Citations: 22     Fields:    Translation:AnimalsCells
  56. Sauvageot CM, Stiles CD. Molecular mechanisms controlling cortical gliogenesis. Curr Opin Neurobiol. 2002 Jun; 12(3):244-9. PMID: 12049929.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  57. Lu QR, Sun T, Zhu Z, Ma N, Garcia M, Stiles CD, Rowitch DH. Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connection. Cell. 2002 Apr 05; 109(1):75-86. PMID: 11955448.
    Citations: 317     Fields:    Translation:AnimalsCells
  58. Alberta JA, Park SK, Mora J, Yuk D, Pawlitzky I, Iannarelli P, Vartanian T, Stiles CD, Rowitch DH. Sonic hedgehog is required during an early phase of oligodendrocyte development in mammalian brain. Mol Cell Neurosci. 2001 Oct; 18(4):434-41. PMID: 11640898.
    Citations: 21     Fields:    Translation:AnimalsCells
  59. Lu QR, Cai L, Rowitch D, Cepko CL, Stiles CD. Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex. Nat Neurosci. 2001 Oct; 4(10):973-4. PMID: 11574831.
    Citations: 35     Fields:    Translation:AnimalsCells
  60. Sun T, Echelard Y, Lu R, Yuk DI, Kaing S, Stiles CD, Rowitch DH. Olig bHLH proteins interact with homeodomain proteins to regulate cell fate acquisition in progenitors of the ventral neural tube. Curr Biol. 2001 Sep 18; 11(18):1413-20. PMID: 11566099.
    Citations: 27     Fields:    Translation:AnimalsCells
  61. Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. Proc Natl Acad Sci U S A. 2001 Sep 11; 98(19):10851-6. PMID: 11526205.
    Citations: 40     Fields:    Translation:HumansCells
  62. Tekki-Kessaris N, Woodruff R, Hall AC, Gaffield W, Kimura S, Stiles CD, Rowitch DH, Richardson WD. Hedgehog-dependent oligodendrocyte lineage specification in the telencephalon. Development. 2001 Jul; 128(13):2545-54. PMID: 11493571.
    Citations: 80     Fields:    Translation:AnimalsCells
  63. Woodruff RH, Tekki-Kessaris N, Stiles CD, Rowitch DH, Richardson WD. Oligodendrocyte development in the spinal cord and telencephalon: common themes and new perspectives. Int J Dev Neurosci. 2001 Jul; 19(4):379-85. PMID: 11378298.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  64. Kim HA, Ratner N, Roberts TM, Stiles CD. Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1. J Neurosci. 2001 Feb 15; 21(4):1110-6. PMID: 11160381.
    Citations: 33     Fields:    Translation:AnimalsCells
  65. Kilic T, Alberta JA, Zdunek PR, Acar M, Iannarelli P, O'Reilly T, Buchdunger E, Black PM, Stiles CD. Intracranial inhibition of platelet-derived growth factor-mediated glioblastoma cell growth by an orally active kinase inhibitor of the 2-phenylaminopyrimidine class. Cancer Res. 2000 Sep 15; 60(18):5143-50. PMID: 11016641.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  66. Wang WL, Healy ME, Sattler M, Verma S, Lin J, Maulik G, Stiles CD, Griffin JD, Johnson BE, Salgia R. Growth inhibition and modulation of kinase pathways of small cell lung cancer cell lines by the novel tyrosine kinase inhibitor STI 571. Oncogene. 2000 Jul 20; 19(31):3521-8. PMID: 10918610.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  67. Kim HA, Pomeroy SL, Whoriskey W, Pawlitzky I, Benowitz LI, Sicinski P, Stiles CD, Roberts TM. A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1. Neuron. 2000 May; 26(2):405-16. PMID: 10839359.
    Citations: 16     Fields:    Translation:AnimalsCells
  68. Lu QR, Yuk D, Alberta JA, Zhu Z, Pawlitzky I, Chan J, McMahon AP, Stiles CD, Rowitch DH. Sonic hedgehog--regulated oligodendrocyte lineage genes encoding bHLH proteins in the mammalian central nervous system. Neuron. 2000 Feb; 25(2):317-29. PMID: 10719888.
    Citations: 213     Fields:    Translation:AnimalsCells
  69. Park JK, Williams BP, Alberta JA, Stiles CD. Bipotent cortical progenitor cells process conflicting cues for neurons and glia in a hierarchical manner. J Neurosci. 1999 Dec 01; 19(23):10383-9. PMID: 10575035.
    Citations: 6     Fields:    Translation:AnimalsCells
  70. Alberta JA, Auger KR, Batt D, Iannarelli P, Hwang G, Elliott HL, Duke R, Roberts TM, Stiles CD. Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathway. J Biol Chem. 1999 Oct 22; 274(43):31062-7. PMID: 10521506.
    Citations: 4     Fields:    Translation:AnimalsCells
  71. Watson FL, Porcionatto MA, Bhattacharyya A, Stiles CD, Segal RA. TrkA glycosylation regulates receptor localization and activity. J Neurobiol. 1999 May; 39(2):323-36. PMID: 10235685.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  72. Kim JY, Sutton ME, Lu DJ, Cho TA, Goumnerova LC, Goritchenko L, Kaufman JR, Lam KK, Billet AL, Tarbell NJ, Wu J, Allen JC, Stiles CD, Segal RA, Pomeroy SL. Activation of neurotrophin-3 receptor TrkC induces apoptosis in medulloblastomas. Cancer Res. 1999 Feb 01; 59(3):711-9. PMID: 9973222.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  73. Dahia PL, Aguiar RC, Alberta J, Kum JB, Caron S, Sill H, Marsh DJ, Ritz J, Freedman A, Stiles C, Eng C. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies. Hum Mol Genet. 1999 Feb; 8(2):185-93. PMID: 9931326.
    Citations: 60     Fields:    Translation:HumansCells
  74. Stiles CD. Cancer of the central nervous system. Review of an AACR special conference in cancer research with the joint section on tumors of the AANS/CNS (San Diego, CA, June 7-11, 1997). Biochim Biophys Acta. 1998 Feb 20; 1377(1):R1-10. PMID: 9540811.
    Citations: 4     Fields:    Translation:HumansAnimals
  75. Kwon YK, Bhattacharyya A, Alberta JA, Giannobile WV, Cheon K, Stiles CD, Pomeroy SL. Activation of ErbB2 during wallerian degeneration of sciatic nerve. J Neurosci. 1997 Nov 01; 17(21):8293-9. PMID: 9334404.
    Citations: 19     Fields:    Translation:AnimalsCells
  76. Shamah SM, Alberta JA, Giannobile WV, Guha A, Kwon YK, Carroll RS, Black PM, Stiles CD. Detection of activated platelet-derived growth factor receptors in human meningioma. Cancer Res. 1997 Sep 15; 57(18):4141-7. PMID: 9307305.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  77. Bhattacharyya A, Watson FL, Bradlee TA, Pomeroy SL, Stiles CD, Segal RA. Trk receptors function as rapid retrograde signal carriers in the adult nervous system. J Neurosci. 1997 Sep 15; 17(18):7007-16. PMID: 9278536.
    Citations: 22     Fields:    Translation:AnimalsCells
  78. Alberta JA, Stiles CD. Phosphorylation-directed antibodies in high-flux screens for compounds that modulate signal transduction. Biotechniques. 1997 Sep; 23(3):490-3. PMID: 9298221.
    Citations:    Fields:    Translation:HumansCells
  79. Williams BP, Park JK, Alberta JA, Muhlebach SG, Hwang GY, Roberts TM, Stiles CD. A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells. Neuron. 1997 Apr; 18(4):553-62. PMID: 9136765.
    Citations: 18     Fields:    Translation:AnimalsCells
  80. Reinertsen KK, Bronson RT, Stiles CD, Wang C. Temporal and spatial specificity of PDGF alpha receptor promoter in transgenic mice. Gene Expr. 1997; 6(5):301-14. PMID: 9368101.
    Citations: 4     Fields:    Translation:AnimalsCells
  81. Segal RA, Bhattacharyya A, Rua LA, Alberta JA, Stephens RM, Kaplan DR, Stiles CD. Differential utilization of Trk autophosphorylation sites. J Biol Chem. 1996 Aug 16; 271(33):20175-81. PMID: 8702742.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  82. Freter RR, Alberta JA, Hwang GY, Wrentmore AL, Stiles CD. Platelet-derived growth factor induction of the immediate-early gene MCP-1 is mediated by NF-kappaB and a 90-kDa phosphoprotein coactivator. J Biol Chem. 1996 Jul 19; 271(29):17417-24. PMID: 8663287.
    Citations: 19     Fields:    Translation:AnimalsCells
  83. Raptis LH, Brownell HL, Liu SK, Firth KL, MacKenzie LW, Stiles CD, Alberta JA. Applications of electroporation of adherent cells in situ, on a partly conductive slide. Mol Biotechnol. 1995 Oct; 4(2):129-38. PMID: 8556428.
    Citations: 1     Fields:    Translation:AnimalsCells
  84. Segal RA, Pomeroy SL, Stiles CD. Axonal growth and fasciculation linked to differential expression of BDNF and NT3 receptors in developing cerebellar granule cells. J Neurosci. 1995 Jul; 15(7 Pt 1):4970-81. PMID: 7623126.
    Citations: 39     Fields:    Translation:AnimalsCells
  85. Guha A, Glowacka D, Carroll R, Dashner K, Black PM, Stiles CD. Expression of platelet derived growth factor and platelet derived growth factor receptor mRNA in a glioblastoma from a patient with Li-Fraumeni syndrome. J Neurol Neurosurg Psychiatry. 1995 Jun; 58(6):711-4. PMID: 7608673.
    Citations: 2     Fields:    Translation:Humans
  86. Guha A, Dashner K, Black PM, Wagner JA, Stiles CD. Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Int J Cancer. 1995 Jan 17; 60(2):168-73. PMID: 7829210.
    Citations: 65     Fields:    Translation:Humans
  87. Raptis LH, Liu SK, Firth KL, Stiles CD, Alberta JA. Electroporation of peptides into adherent cells in situ. Biotechniques. 1995 Jan; 18(1):104, 106, 108, 110 passim. PMID: 7702835.
    Citations: 2     Fields:    Translation:AnimalsCells
  88. Freter RR, Alberta JA, Lam KK, Stiles CD. A new platelet-derived growth factor-regulated genomic element which binds a serine/threonine phosphoprotein mediates induction of the slow immediate-early gene MCP-1. Mol Cell Biol. 1995 Jan; 15(1):315-25. PMID: 7799939.
    Citations: 6     Fields:    Translation:AnimalsCells
  89. Shamah SM, Stiles CD. Transdominant negative mutations. Methods Enzymol. 1995; 254:565-76. PMID: 8531715.
    Citations: 3     Fields:    Translation:AnimalsCells
  90. Segal RA, Goumnerova LC, Kwon YK, Stiles CD, Pomeroy SL. Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12867-71. PMID: 7809137.
    Citations: 60     Fields:    Translation:Humans
  91. Wang C, Stiles CD. Platelet-derived growth factor alpha receptor gene expression: isolation and characterization of the promoter and upstream regulatory elements. Proc Natl Acad Sci U S A. 1994 Jul 19; 91(15):7061-5. PMID: 8041746.
    Citations: 6     Fields:    Translation:AnimalsCells
  92. Alberta JA, Rundell K, Stiles CD. Identification of an activity that interacts with the 3'-untranslated region of c-myc mRNA and the role of its target sequence in mediating rapid mRNA degradation. J Biol Chem. 1994 Feb 11; 269(6):4532-8. PMID: 8308023.
    Citations: 13     Fields:    Translation:AnimalsCells
  93. Shamah SM, Stiles CD, Guha A. Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells. Mol Cell Biol. 1993 Dec; 13(12):7203-12. PMID: 8246942.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  94. Wang C, Stiles CD. Regulation of platelet-derived growth factor A messenger RNA translation in differentiating F9 teratocarcinoma cells. Cell Growth Differ. 1993 Oct; 4(10):871-7. PMID: 8274456.
    Citations: 3     Fields:    Translation:AnimalsCells
  95. Mudhar HS, Pollock RA, Wang C, Stiles CD, Richardson WD. PDGF and its receptors in the developing rodent retina and optic nerve. Development. 1993 Jun; 118(2):539-52. PMID: 8223278.
    Citations: 26     Fields:    Translation:AnimalsCells
  96. Jones SD, Ho L, Smith JC, Yordan C, Stiles CD, Mercola M. The Xenopus platelet-derived growth factor alpha receptor: cDNA cloning and demonstration that mesoderm induction establishes the lineage-specific pattern of ligand and receptor gene expression. Dev Genet. 1993; 14(3):185-93. PMID: 8358864.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  97. Freter RR, Irminger JC, Porter JA, Jones SD, Stiles CD. A novel 7-nucleotide motif located in 3' untranslated sequences of the immediate-early gene set mediates platelet-derived growth factor induction of the JE gene. Mol Cell Biol. 1992 Dec; 12(12):5288-300. PMID: 1448065.
    Citations: 16     Fields:    Translation:AnimalsCells
  98. Palmieri SL, Payne J, Stiles CD, Biggers JD, Mercola M. Expression of mouse PDGF-A and PDGF alpha-receptor genes during pre- and post-implantation development: evidence for a developmental shift from an autocrine to a paracrine mode of action. Mech Dev. 1992 Dec; 39(3):181-91. PMID: 1292572.
    Citations: 13     Fields:    Translation:AnimalsCells
  99. Epstein RJ, Druker BJ, Roberts TM, Stiles CD. Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10435-9. PMID: 1359539.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  100. Epstein RJ, Druker BJ, Irminger JC, Jones SD, Roberts TM, Stiles CD. Extracellular calcium mimics the actions of platelet-derived growth factor on mouse fibroblasts. Cell Growth Differ. 1992 Mar; 3(3):157-64. PMID: 1352989.
    Citations:    Fields:    Translation:AnimalsCells
  101. Wang C, Shamah SM, Stiles CD. Recombinant PDGF from lower vertebrates: receptor binding and immunochemical analysis with metabolically labeled growth factor. Growth Factors. 1992; 7(4):279-88. PMID: 1306683.
    Citations:    Fields:    Translation:HumansAnimalsCells
  102. Yaeger PC, Stiles CD, Rollins BJ. Human keratinocyte growth-promoting activity on the surface of fibroblasts. J Cell Physiol. 1991 Oct; 149(1):110-6. PMID: 1939339.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  103. Stephenson DA, Mercola M, Anderson E, Wang CY, Stiles CD, Bowen-Pope DF, Chapman VM. Platelet-derived growth factor receptor alpha-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation. Proc Natl Acad Sci U S A. 1991 Jan 01; 88(1):6-10. PMID: 1846043.
    Citations: 40     Fields:    Translation:AnimalsCells
  104. Mercola M, Deininger PL, Shamah SM, Porter J, Wang CY, Stiles CD. Dominant-negative mutants of a platelet-derived growth factor gene. Genes Dev. 1990 Dec; 4(12B):2333-41. PMID: 2279701.
    Citations: 16     Fields:    Translation:AnimalsCells
  105. Wang C, Kelly J, Bowen-Pope DF, Stiles CD. Retinoic acid promotes transcription of the platelet-derived growth factor alpha-receptor gene. Mol Cell Biol. 1990 Dec; 10(12):6781-4. PMID: 2174116.
    Citations: 9     Fields:    Translation:AnimalsCells
  106. Epstein RJ, Druker BJ, Roberts TM, Stiles CD. Modulation of a Mr 175,000 c-neu receptor isoform in G8/DHFR cells by serum starvation. J Biol Chem. 1990 Jun 25; 265(18):10746-51. PMID: 1972380.
    Citations: 6     Fields:    Translation:AnimalsCells
  107. Mercola M, Wang CY, Kelly J, Brownlee C, Jackson-Grusby L, Stiles C, Bowen-Pope D. Selective expression of PDGF A and its receptor during early mouse embryogenesis. Dev Biol. 1990 Mar; 138(1):114-22. PMID: 2155144.
    Citations: 37     Fields:    Translation:AnimalsCells
  108. Garcia-Blanco MA, Porter JA, Morrison ED, Stiles CD. The beta-interferon-mediated antimitogenic state resembles the anti-viral state. Oncogene Res. 1990; 5(4):323-8. PMID: 2204022.
    Citations: 1     Fields:    Translation:AnimalsCells
  109. Ahmed K, Mahony J, Stiles C, Castriciano S, Chernesky M. A clinical virology database for a regional virology service. J Virol Methods. 1989 Dec; 26(3):255-67. PMID: 2621240.
    Citations:    Fields:    Translation:Humans
  110. Hall DJ, Brownlee C, Stiles CD. Interleukin-1 is a potent regulator of JE and KC gene expression in quiescent BALB/c fibroblasts. J Cell Physiol. 1989 Oct; 141(1):154-9. PMID: 2506194.
    Citations: 12     Fields:    Translation:AnimalsCells
  111. Rollins BJ, O'Connell TM, Bennett G, Burton LE, Stiles CD, Rheinwald JG. Environment-dependent growth inhibition of human epidermal keratinocytes by recombinant human transforming growth factor-beta. J Cell Physiol. 1989 Jun; 139(3):455-62. PMID: 2472411.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  112. Hall DJ, Jones SD, Kaplan DR, Whitman M, Rollins BJ, Stiles CD. Evidence for a novel signal transduction pathway activated by platelet-derived growth factor and by double-stranded RNA. Mol Cell Biol. 1989 Apr; 9(4):1705-13. PMID: 2542776.
    Citations: 8     Fields:    Translation:AnimalsCells
  113. Oquendo P, Alberta J, Wen DZ, Graycar JL, Derynck R, Stiles CD. The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins. J Biol Chem. 1989 Mar 05; 264(7):4133-7. PMID: 2917992.
    Citations: 69     Fields:    Translation:HumansAnimalsCells
  114. Garcia-Blanco MA, Lengyel P, Morrison E, Brownlee C, Stiles CD, Rutherford M, Hannigan G, Williams BR. Regulation of 2',5'-oligoadenylate synthetase gene expression by interferons and platelet-derived growth factor. Mol Cell Biol. 1989 Mar; 9(3):1060-8. PMID: 2542764.
    Citations: 3     Fields:    Translation:AnimalsCells
  115. Hall DJ, Alberta JA, Stiles CD. Labile repressors are involved in the transcriptional control of PDGF-responsive genes. Oncogene Res. 1989; 4(3):177-84. PMID: 2544848.
    Citations: 5     Fields:    Translation:AnimalsCells
  116. Rollins BJ, Stiles CD. Serum-inducible genes. Adv Cancer Res. 1989; 53:1-32. PMID: 2678945.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  117. Mercola M, Melton DA, Stiles CD. Platelet-derived growth factor A chain is maternally encoded in Xenopus embryos. Science. 1988 Sep 02; 241(4870):1223-5. PMID: 3413486.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  118. Burd PR, Rollins BJ, Wilson SD, Billings PR, Stiles CD, Dorf ME. Comparison of fibroblast and T-cell activation genes. Cell Immunol. 1988 Sep; 115(2):481-3. PMID: 3261640.
    Citations: 5     Fields:    Translation:AnimalsCells
  119. Rollins BJ, Morrison ED, Stiles CD. Cloning and expression of JE, a gene inducible by platelet-derived growth factor and whose product has cytokine-like properties. Proc Natl Acad Sci U S A. 1988 Jun; 85(11):3738-42. PMID: 3287374.
    Citations: 91     Fields:    Translation:AnimalsCells
  120. Mercola M, Stiles CD. Growth factor superfamilies and mammalian embryogenesis. Development. 1988 Mar; 102(3):451-60. PMID: 3053123.
    Citations: 22     Fields:    Translation:HumansAnimals
  121. Rollins BJ, Stiles CD. Regulation of c-myc and c-fos proto-oncogene expression by animal cell growth factors. In Vitro Cell Dev Biol. 1988 Feb; 24(2):81-4. PMID: 3125143.
    Citations: 8     Fields:    Translation:AnimalsCells
  122. Jones SD, Hall DJ, Rollins BJ, Stiles CD. Platelet-derived growth factor generates at least two distinct intracellular signals that modulate gene expression. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:531-6. PMID: 3254779.
    Citations: 2     Fields:    Translation:AnimalsCells
  123. Rollins BJ, Stiles CD. Molecular regulation of growth control: implications for wound healing. Prog Clin Biol Res. 1988; 266:19-22. PMID: 3289043.
    Citations:    Fields:    Translation:AnimalsCells
  124. Rollins BJ, Morrison ED, Stiles CD. A cell-cycle constraint on the regulation of gene expression by platelet-derived growth factor. Science. 1987 Nov 27; 238(4831):1269-71. PMID: 3685976.
    Citations: 9     Fields:    Translation:AnimalsCells
  125. Hall DJ, Stiles CD. Platelet-derived growth factor-inducible genes respond differentially to at least two distinct intracellular second messengers. J Biol Chem. 1987 Nov 05; 262(31):15302-8. PMID: 3117798.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  126. Zumstein P, Stiles CD. Molecular cloning of gene sequences that are regulated by insulin-like growth factor I. J Biol Chem. 1987 Aug 15; 262(23):11252-60. PMID: 3611109.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  127. Zullo J, Stiles CD, Garcea RL. Regulation of c-myc and c-fos mRNA levels by polyomavirus: distinct roles for the capsid protein VP1 and the viral early proteins. Proc Natl Acad Sci U S A. 1987 Mar; 84(5):1210-4. PMID: 3029770.
    Citations: 41     Fields:    Translation:AnimalsCells
  128. Cochran BH, Zumstein P, Zullo J, Rollins B, Mercola M, Stiles CD. Differential colony hybridization: molecular cloning from a zero data base. Methods Enzymol. 1987; 147:64-85. PMID: 2444861.
    Citations: 3     Fields:    Translation:Cells
  129. Gibson CW, Rittling SR, Hirschhorn RR, Kaczmarek L, Calabretta B, Stiles CD, Baserga R. Cell cycle dependent genes inducible by different mitogens in cells from different species. Mol Cell Biochem. 1986 Jun; 71(1):61-9. PMID: 3755218.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  130. Zullo JN, Cochran BH, Huang AS, Stiles CD. Platelet-derived growth factor and double-stranded ribonucleic acids stimulate expression of the same genes in 3T3 cells. Cell. 1985 Dec; 43(3 Pt 2):793-800. PMID: 3000615.
    Citations: 62     Fields:    Translation:AnimalsCells
  131. Stiles CD. The biological role of oncogenes--insights from platelet-derived growth factor: Rhoads Memorial Award lecture. Cancer Res. 1985 Nov; 45(11 Pt 1):5215-8. PMID: 2996757.
    Citations: 9     Fields:    Translation:HumansAnimals
  132. Callahan M, Cochran BH, Stiles CD. The PDGF-inducible 'competence genes': intracellular mediators of the mitogenic response. Ciba Found Symp. 1985; 116:87-97. PMID: 4075904.
    Citations: 4     Fields:    Translation:AnimalsCells
  133. Cochran BH, Zullo J, Verma IM, Stiles CD. Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor. Science. 1984 Nov 30; 226(4678):1080-2. PMID: 6093261.
    Citations: 125     Fields:    Translation:AnimalsCells
  134. Stiles CD. Autocrine control of growth? Nature. 1984 Oct 18-24; 311(5987):604-5. PMID: 6384794.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  135. Armelin HA, Armelin MC, Kelly K, Stewart T, Leder P, Cochran BH, Stiles CD. Functional role for c-myc in mitogenic response to platelet-derived growth factor. Nature. 1984 Aug 23-29; 310(5979):655-60. PMID: 6088986.
    Citations: 144     Fields:    Translation:AnimalsCells
  136. Bockus BJ, Stiles CD. Regulation of cytoskeletal architecture by platelet-derived growth factor, insulin and epidermal growth factor. Exp Cell Res. 1984 Jul; 153(1):186-97. PMID: 6376151.
    Citations: 27     Fields:    Translation:AnimalsCells
  137. Bockus BJ, Scher CD, Stiles CD. Use of defined media for analysis of the action of platelet-derived growth factor on fibroblasts. Prog Clin Biol Res. 1984; 154:133-41. PMID: 6382290.
    Citations:    Fields:    Translation:HumansAnimalsCells
  138. Hendrickson SL, Cochran BH, Reffel AC, Stiles CD. Regulation of gene expression by serum and serum growth factors. Symp Fundam Cancer Res. 1984; 37:71-85. PMID: 6335592.
    Citations:    Translation:AnimalsCells
  139. Kelly K, Cochran B, Stiles C, Leder P. The regulation of c-myc by growth signals. Curr Top Microbiol Immunol. 1984; 113:117-26. PMID: 6332711.
    Citations: 5     Fields:    Translation:AnimalsCells
  140. Kelly K, Cochran BH, Stiles CD, Leder P. Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor. Cell. 1983 Dec; 35(3 Pt 2):603-10. PMID: 6606489.
    Citations: 602     Fields:    Translation:AnimalsCells
  141. Cochran BH, Reffel AC, Stiles CD. Molecular cloning of gene sequences regulated by platelet-derived growth factor. Cell. 1983 Jul; 33(3):939-47. PMID: 6872001.
    Citations: 242     Fields:    Translation:AnimalsCells
  142. Stiles CD. The molecular biology of platelet-derived growth factor. Cell. 1983 Jul; 33(3):653-5. PMID: 6307524.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  143. Singh JP, Chaikin MA, Pledger WJ, Scher CD, Stiles CD. Persistence of the mitogenic response to platelet-derived growth factor (competence) does not reflect a long-term interaction between the growth factor and the target cell. J Cell Biol. 1983 May; 96(5):1497-502. PMID: 6841457.
    Citations: 12     Fields:    Translation:AnimalsCells
  144. Singh JP, Chaikin MA, Stiles CD. Phylogenetic analysis of platelet-derived growth factor by radio-receptor assay. J Cell Biol. 1982 Nov; 95(2 Pt 1):667-71. PMID: 7142300.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  145. Smith JC, Singh JP, Lillquist JS, Goon DS, Stiles CD. Growth factors adherent to cell substrate are mitogenically active in situ. Nature. 1982 Mar 11; 296(5853):154-6. PMID: 6278315.
    Citations: 20     Fields:    Translation:AnimalsCells
  146. Cochran BH, Lillquist JS, Stiles CD. Post-transcriptional control of protein synthesis in Balb/c-3T3 cells by platelet-derived growth factor and platelet-poor plasma. J Cell Physiol. 1981 Dec; 109(3):429-38. PMID: 6798044.
    Citations: 5     Fields:    Translation:AnimalsCells
  147. Smith JC, Stiles CD. Cytoplasmic transfer of the mitogenic response to platelet-derived growth factor. Proc Natl Acad Sci U S A. 1981 Jul; 78(7):4363-7. PMID: 6170063.
    Citations: 15     Fields:    Translation:AnimalsCells
  148. Frantz CN, Stiles CD, Pledger WJ, Scher CD. Effect of ouabain on growth regulation by serum components in Balb/c-3T3 cells: inhibition of entry into S phase by decreased protein synthesis. J Cell Physiol. 1980 Dec; 105(3):439-48. PMID: 6257737.
    Citations: 2     Fields:    Translation:AnimalsCells
  149. Martin RG, Setlow VP, Chepelinsky AB, Seif R, Lewis AM, Scher CD, Stiles CD, Avila J. Roles of the T antigens in transformation by SV40. Cold Spring Harb Symp Quant Biol. 1980; 44 Pt 1,:311-24. PMID: 6253146.
    Citations: 4     Fields:    Translation:AnimalsCells
  150. Stiles CD, Pledger WJ, Tucker RW, Martin RG, Scher CD. Regulation of the Balb/c-3T3 cell cycle-effects of growth factors. J Supramol Struct. 1980; 13(4):489-99. PMID: 6453256.
    Citations: 8     Fields:    Translation:AnimalsCells
  151. Scher CD, Farhi JI, Handin RI, Kaplan DR, Lillquist JS, McGovern K, Stiles CD. Initiation of cell replication by cationic polypeptide hormones. Soc Gen Physiol Ser. 1980; 35:39-54. PMID: 7414371.
    Citations:    Fields:    Translation:AnimalsCells
  152. Tucker RW, Scher CD, Stiles CD. Centriole deciliation associated with the early response of 3T3 cells to growth factors but not to SV40. Cell. 1979 Dec; 18(4):1065-72. PMID: 229969.
    Citations: 33     Fields:    Translation:AnimalsCells
  153. Scher CD, Stone ME, Stiles CD. Platelet-derived growth factor prevents G0 growth arrest. Nature. 1979 Oct 04; 281(5730):390-2. PMID: 481605.
    Citations: 10     Fields:    Translation:AnimalsCells
  154. Frantz CN, Stiles CD, Scher CD. The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate enhances the proliferative response of Balb/c-3T3 cells to hormonal growth factors. J Cell Physiol. 1979 Sep; 100(3):413-24. PMID: 314942.
    Citations: 22     Fields:    Translation:AnimalsCells
  155. Scher CD, Shepard RC, Antoniades HN, Stiles CD. Platelet-derived growth factor and the regulation of the mammalian fibroblast cell cycle. Biochim Biophys Acta. 1979 Aug 10; 560(2):217-41. PMID: 380651.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  156. Stiles CD, Isberg RR, Pledger WJ, Antoniades HN, Scher CD. Control of the Balb/c-3T3 cell cycle by nutrients and serum factors: analysis using platelet-derived growth factor and platelet-poor plasma. J Cell Physiol. 1979 Jun; 99(3):395-405. PMID: 222785.
    Citations: 22     Fields:    Translation:AnimalsCells
  157. Kaplan DR, Chao FC, Stiles CD, Antoniades HN, Scher CD. Platelet alpha granules contain a growth factor for fibroblasts. Blood. 1979 Jun; 53(6):1043-52. PMID: 444648.
    Citations: 67     Fields:    Translation:HumansAnimalsCells
  158. Reid LM, Stiles CD, Saier MH, Rindler MJ. Growth of nontumorigenic cells in Millipore diffusion chambers implanted in mice and implications for in vivo growth regulation. Cancer Res. 1979 May; 39(5):1467-73. PMID: 427791.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  159. Antoniades HN, Scher CD, Stiles CD. Purification of human platelet-derived growth factor. Proc Natl Acad Sci U S A. 1979 Apr; 76(4):1809-13. PMID: 287022.
    Citations: 126     Fields:    Translation:HumansCells
  160. Stiles CD, Capone GT, Scher CD, Antoniades HN, Van Wyk JJ, Pledger WJ. Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc Natl Acad Sci U S A. 1979 Mar; 76(3):1279-83. PMID: 312500.
    Citations: 147     Fields:    Translation:HumansAnimalsCells
  161. Scher CD, Stiles CD, Antoniades HN, Pledger WJ. Regulation of the mammalian fibroblast cell cycle by a platelet-derived growth factor. Prog Clin Biol Res. 1979; 31:611-20. PMID: 538019.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  162. Scher CD, Pledger WJ, Martin P, Antoniades H, Stiles CD. Transforming viruses directly reduce the cellular growth requirement for a platelet derived growth factor. J Cell Physiol. 1978 Dec; 97(3 Pt 1):371-80. PMID: 215597.
    Citations: 30     Fields:    Translation:HumansCells
  163. Pledger WJ, Stiles CD, Antoniades HN and Scher CD. An ordered sequence of events is required before BALB/c-3T3 cells become committed to DNA synthesis. Proc Natl Acad Sci U S A . 1978; (75):2839-43.
  164. Pledger WJ, Stiles CD, Antoniades HN, Scher CD. Induction of DNA synthesis in BALB/c 3T3 cells by serum components: reevaluation of the commitment process. Proc Natl Acad Sci U S A. 1977 Oct; 74(10):4481-5. PMID: 270695.
    Citations: 137     Fields:    Translation:HumansAnimalsCells
  165. Stiles CD, Desmond W, Chuman LM, Sato G, Saier MH. Relationship of cell growth behavior in vitro to tumorigenicity in athymic nude mice. Cancer Res. 1976 Sep; 36(9 pt.1):3300-5. PMID: 975091.
    Citations: 26     Fields:    Translation:AnimalsCells
  166. Stiles CD, Desmond W, Chuman LM, Sato G, Saier MH. Growth control of heterologous tissue culture cells in the congenitally athymic nude mouse. Cancer Res. 1976 Apr; 36(4):1353-60. PMID: 1260760.
    Citations: 13     Fields:    Translation:AnimalsCellsPHPublic Health
  167. Stiles CD, Roberts PE, Saier MH, Sato G. Growth regulation and suppression of metastasis in the congenitally athymic nude mouse. Hamatol Bluttransfus. 1976; 19:185-94. PMID: 188726.
    Citations:    Fields:    Translation:AnimalsCells
  168. Stiles CD, Desmond W, Sato G, Saier MH. Failure of human cells transformed by simian virus 40 to form tumors in athymic nude mice. Proc Natl Acad Sci U S A. 1975 Dec; 72(12):4971-5. PMID: 174085.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  169. Kenney FT, Lee KL, Stiles CD, Fritz JE. Further evidence against post-transcriptional control of inducible tyrosine aminotransferase synthesis in cultured hepatoma cells. Nat New Biol. 1973 Dec 19; 246(155):208-10. PMID: 4148697.
    Citations: 8     Fields:    Translation:Cells
  170. Kenney FT, Lee KL, Stiles CD and Fritz JE. Further evidence against post-transcriptional control of inducible tyrosine aminotransferase synthesis in cultured hepatoma cells. Nat New Biol . 1973; (246):208-10.
  171. Kenney FT, Lee KL, Stiles CD. Degradation of messenger RNA in mammalian cells. Acta Endocrinol Suppl (Copenh). 1972; 168:369-80. PMID: 4404131.
    Citations: 3     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.