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Satoshi Kashiwagi, Ph.D., M.D.

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Biography
Keio University School of Medicine, Tokyo, JapanM.D.03/1997Medicine
Keio University Hospital, Tokyo, JapanResidency05/1998Obstetrics and Gynecology
Saiseikai Kanagawa-Ken Hospital, Yokohama, JapanResidency05/1999Obstetrics and Gynecology
Otawara Red-Cross Hospital, Tochigi-Prefecture, JapanResidency05/2000Obstetrics and Gynecology
Tokyo Dental Collage Ichikawa General Hospital, Chiba-Prefecture, JapanClinical Fellowship05/2001Obstetrics and Gynecology
Keio University Graduate School of Medicine, Tokyo, JapanPh.D.03/2004Biochemistry / Obstetrics and Gynecology
Massachusetts General Hospital, BostonResearch Fellowship12/2006Radiation Oncology
Massachusetts General Hospital, BostonResearch Fellowship12/2008Cardiovascular Medicine
Massachusetts General Hospital, BostonResearch Fellowship05/2009Immunology

Overview
I am a physician scientist who possesses a broad and unique skill set for basic and translational research in the field of bioimaging, immunology, cancer biology and laser medicine. My laboratory at Massachusetts General Hospital is currently establishing safe, effective, simple, and affordable immunotherapy for infectious diseases, allergy, autoimmune diseases and cancer using the near-infrared laser technology. I also have a strong background in clinical medicine where I spent more than four years and gained valuable knowledge as an obstetrician in Japan.
Results from my laboratory uncovered that brief exposures of low power NIR laser light on skin, which is known to be enriched with immune cells, reproducibly control the immune response without side effects. Since lasers have been extensively used in various medical procedures for more than three decades, technology and safety in applying laser light to human body has been well established already. Such a new modality may replace the current standard cancer care with concomitant high cost and side effects. We believe that -light- is the right technology for rapid translation into the clinic.
With the skills and training I have gained, I am in a unique position to help bridge the gap between studies at the cell and molecular level - where some of the most exciting advances are being made in modern research laboratories - and studies in real models of vaccination and tumorigenesis where all these basic developments must be tested further before they are applied to human patients.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI144103 (KASHIWAGI, SATOSHI) Feb 1, 2019 - Jan 31, 2021
    NIH/NIAID
    Laser-based non-invasive immunotherapy for food allergy
    Role: Principal Investigator
  2. DOM Innovation Grant Program (KASHIWAGI, SATOSHI) Jul 1, 2016 - Jun 30, 2017
    MGH Department of Medicine
    Near-infrared laser to augment antigen-specific tolerance for treatment of autoimmune diseases
    Role: Principal Investigator
  3. R42AI114012 (BEAN, DAVID) Jul 1, 2014 - Jul 31, 2018
    NIH
    Development of small near-infrared laser system capable of improving immune responses to vaccines (laser-based adjuvant)
    Role: Subcontract PI
  4. R41AI114012 (CALLAHAN, JOHN JAMES) Jul 1, 2014 - Jun 30, 2015
    NIH
    Development of small near-infrared laser system capable of improving immune respo
    Role: Subcontract PI
  5. R01AI105131 (KASHIWAGI, SATOSHI) Sep 1, 2013 - Aug 31, 2017
    NIH/NIAID
    Near-infrared laser to replace chemical vaccine adjuvant
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Yadav Y, Owens E, Nomura S, Fukuda T, Baek Y, Kashiwagi S, Choi HS, Henary M. Ultrabright and Serum-Stable Squaraine Dyes. J Med Chem. 2020 Sep 10; 63(17):9436-9445. PMID: 32787096.
    Citations:    
  2. Ji Y, Jones C, Baek Y, Park GK, Kashiwagi S, Choi HS. Near-infrared fluorescence imaging in immunotherapy. Adv Drug Deliv Rev. 2020 Jun 21. PMID: 32579891.
    Citations:    
  3. Park GK, Lee JH, Soriano E, Choi M, Bao K, Katagiri W, Kim DY, Paik JH, Yun SH, Frangioni JV, Clancy TE, Kashiwagi S, Henary M, Choi HS. Rapid and Selective Targeting of Heterogeneous Pancreatic Neuroendocrine Tumors. iScience. 2020 Apr 24; 23(4):101006. PMID: 32268281.
    Citations:    
  4. Katagiri W, Lee G, Tanushi A, Tsukada K, Choi HS, Kashiwagi S. High-throughput single-cell live imaging of photobiomodulation with multispectral near-infrared lasers in cultured T cells. J Biomed Opt. 2020 03; 25(3):1-18. PMID: 32193907.
    Citations:    
  5. Kashiwagi S. Laser adjuvant for vaccination. FASEB J. 2020 Mar; 34(3):3485-3500. PMID: 31994227.
    Citations:    
  6. Kang H, Rho S, Stiles WR, Hu S, Baek Y, Hwang DW, Kashiwagi S, Kim MS, Choi HS. Size-Dependent EPR Effect of Polymeric Nanoparticles on Tumor Targeting. Adv Healthc Mater. 2020 01; 9(1):e1901223. PMID: 31794153.
    Citations:    
  7. Hwang DW, Jo MJ, Lee JH, Kang H, Bao K, Hu S, Baek Y, Moon HG, Lee DS, Kashiwagi S, Henary M, Choi HS. Chemical Modulation of Bioengineered Exosomes for Tissue-Specific Biodistribution. Adv Ther (Weinh). 2019 Nov; 2(11). PMID: 32318623.
    Citations:    
  8. Ji Y, Wang Z, Bao K, Park GK, Kang H, Hu S, McDonald E, Kim MS, Kashiwagi S, Choi HS. Targeted molecular imaging of TLR4 in hepatocellular carcinoma using zwitterionic near-infrared fluorophores. Quant Imaging Med Surg. 2019 Sep; 9(9):1548-1555. PMID: 31667140.
    Citations:    
  9. Katagiri W, Lee JH, Tétrault MA, Kang H, Jeong S, Evans CL, Yokomizo S, Santos S, Jones C, Hu S, Fakhri GE, Tsukada K, Choi HS, Kashiwagi S. Real-Time Imaging of Vaccine Biodistribution Using Zwitterionic NIR Nanoparticles. Adv Healthc Mater. 2019 08; 8(15):e1900035. PMID: 31165556.
    Citations:    
  10. Park GK, Kim SH, Kim K, Das P, Kim BG, Kashiwagi S, Choi HS, Hwang NS. Dual-Channel Fluorescence Imaging of Hydrogel Degradation and Tissue Regeneration in the Brain. Theranostics. 2019; 9(15):4255-4264. PMID: 31285760.
    Citations:    
  11. Kimizuka Y, Katagiri W, Locascio JJ, Shigeta A, Sasaki Y, Shibata M, Morse K, Sîrbulescu RF, Miyatake M, Reeves P, Suematsu M, Gelfand J, Brauns T, Poznansky MC, Tsukada K, Kashiwagi S. Brief Exposure of Skin to Near-Infrared Laser Modulates Mast Cell Function and Augments the Immune Response. J Immunol. 2018 12 15; 201(12):3587-3603. PMID: 30420435.
    Citations:    
  12. Gelfand JA, Nazarian RM, Kashiwagi S, Brauns T, Martin B, Kimizuka Y, Korek S, Botvinick E, Elkins K, Thomas L, Locascio J, Parry B, Kelly KM, Poznansky MC. A pilot clinical trial of a near-infrared laser vaccine adjuvant: safety, tolerability, and cutaneous immune cell trafficking. FASEB J. 2019 02; 33(2):3074-3081. PMID: 30192655.
    Citations:    Fields:    
  13. Reeves PM, Sluder AE, Paul SR, Scholzen A, Kashiwagi S, Poznansky MC. Application and utility of mass cytometry in vaccine development. FASEB J. 2018 01; 32(1):5-15. PMID: 29092906.
    Citations: 1     Fields:    Translation:HumansAnimals
  14. Morse K, Kimizuka Y, Chan MPK, Shibata M, Shimaoka Y, Takeuchi S, Forbes B, Nirschl C, Li B, Zeng Y, Bronson RT, Katagiri W, Shigeta A, Sîrbulescu RF, Chen H, Tan RYY, Tsukada K, Brauns T, Gelfand J, Sluder A, Locascio JJ, Poznansky MC, Anandasabapathy N, Kashiwagi S. Near-Infrared 1064 nm Laser Modulates Migratory Dendritic Cells To Augment the Immune Response to Intradermal Influenza Vaccine. J Immunol. 2017 08 15; 199(4):1319-1332. PMID: 28710250.
    Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
  15. Kimizuka Y, Callahan JJ, Huang Z, Morse K, Katagiri W, Shigeta A, Bronson R, Takeuchi S, Shimaoka Y, Chan MPK, Zeng Y, Li B, Chen H, Tan RYY, Dwyer C, Mulley T, Leblanc P, Goudie C, Gelfand J, Tsukada K, Brauns T, Poznansky MC, Bean D, Kashiwagi S. Semiconductor diode laser device adjuvanting intradermal vaccine. Vaccine. 2017 04 25; 35(18):2404-2412. PMID: 28365253.
    Citations: 2     Fields:    Translation:AnimalsPHPublic Health
  16. Kashiwagi S, Brauns T, Poznansky MC. Classification of Laser Vaccine Adjuvants. J Vaccines Vaccin. 2016 Feb; 7(1). PMID: 27104047.
    Citations: 4     
  17. Chen T, Yuan J, Duncanson S, Hibert ML, Kodish BC, Mylavaganam G, Maker M, Li H, Sremac M, Santosuosso M, Forbes B, Kashiwagi S, Cao J, Lei J, Thomas M, Hartono C, Sachs D, Markmann J, Sambanis A, Poznansky MC. Alginate encapsulant incorporating CXCL12 supports long-term allo- and xenoislet transplantation without systemic immune suppression. Am J Transplant. 2015 Mar; 15(3):618-27. PMID: 25693473.
    Citations: 8     Fields:    Translation:Animals
  18. Yuan J, Kashiwagi S, Reeves P, Nezivar J, Yang Y, Arrifin NH, Nguyen M, Jean-Mary G, Tong X, Uppal P, Korochkina S, Forbes B, Chen T, Righi E, Bronson R, Chen H, Orsulic S, Brauns T, Leblanc P, Scholler N, Dranoff G, Gelfand J, Poznansky MC. A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma. J Hematol Oncol. 2014 Feb 24; 7:15. PMID: 24565018.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  19. Kashiwagi S, Brauns T, Gelfand J, Poznansky MC. Laser vaccine adjuvants. History, progress, and potential. Hum Vaccin Immunother. 2014; 10(7):1892-907. PMID: 25424797.
    Citations: 5     Fields:    Translation:HumansCells
  20. Kashiwagi S, Yuan J, Forbes B, Hibert ML, Lee EL, Whicher L, Goudie C, Yang Y, Chen T, Edelblute B, Collette B, Edington L, Trussler J, Nezivar J, Leblanc P, Bronson R, Tsukada K, Suematsu M, Dover J, Brauns T, Gelfand J, Poznansky MC. Near-infrared laser adjuvant for influenza vaccine. PLoS One. 2013; 8(12):e82899. PMID: 24349390.
    Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
  21. Li Q, Atochin D, Kashiwagi S, Earle J, Wang A, Mandeville E, Hayakawa K, d'Uscio LV, Lo EH, Katusic Z, Sessa W, Huang PL. Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size. Stroke. 2013 Nov; 44(11):3183-8. PMID: 23988642.
    Citations: 15     Fields:    Translation:AnimalsCells
  22. Ayata C, Shin HK, Dileköz E, Atochin DN, Kashiwagi S, Eikermann-Haerter K, Huang PL. Hyperlipidemia disrupts cerebrovascular reflexes and worsens ischemic perfusion defect. J Cereb Blood Flow Metab. 2013 Jun; 33(6):954-62. PMID: 23486293.
    Citations: 10     Fields:    Translation:AnimalsCells
  23. Kashiwagi S, Atochin DN, Li Q, Schleicher M, Pong T, Sessa WC, Huang PL. eNOS phosphorylation on serine 1176 affects insulin sensitivity and adiposity. Biochem Biophys Res Commun. 2013 Feb 08; 431(2):284-90. PMID: 23291238.
    Citations: 13     Fields:    Translation:AnimalsCells
  24. Kashiwagi S, Huang PL. Dietary Supplements and Cardiovascular Disease: What is the Evidence and What Should We Recommend?. Cardiovascular Risk Factors. 2012; 459-464. View Publication.
  25. Righi E, Kashiwagi S, Yuan J, Santosuosso M, Leblanc P, Ingraham R, Forbes B, Edelblute B, Collette B, Xing D, Kowalski M, Mingari MC, Vianello F, Birrer M, Orsulic S, Dranoff G, Poznansky MC. CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer. Cancer Res. 2011 Aug 15; 71(16):5522-5534. PMID: 21742774.
    Citations: 59     Fields:    Translation:Animals
  26. Hovav AH, Santosuosso M, Bivas-Benita M, Plair A, Cheng A, Elnekave M, Righi E, Chen T, Kashiwagi S, Panas MW, Xiang SH, Furmanov K, Letvin NL, Poznansky MC. X4 human immunodeficiency virus type 1 gp120 down-modulates expression and immunogenicity of codelivered antigens. J Virol. 2009 Nov; 83(21):10941-50. PMID: 19692474.
    Citations: 8     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  27. Schleicher M, Yu J, Murata T, Derakhshan B, Atochin D, Qian L, Kashiwagi S, Di Lorenzo A, Harrison KD, Huang PL, Sessa WC. The Akt1-eNOS axis illustrates the specificity of kinase-substrate relationships in vivo. Sci Signal. 2009 Aug 04; 2(82):ra41. PMID: 19654415.
    Citations: 31     Fields:    Translation:AnimalsCells
  28. Lahdenranta J, Hagendoorn J, Padera TP, Hoshida T, Nelson G, Kashiwagi S, Jain RK, Fukumura D. Endothelial nitric oxide synthase mediates lymphangiogenesis and lymphatic metastasis. Cancer Res. 2009 Apr 01; 69(7):2801-8. PMID: 19318557.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  29. Kashiwagi S, Tsukada K, Xu L, Miyazaki J, Kozin SV, Tyrrell JA, Sessa WC, Gerweck LE, Jain RK, Fukumura D. Perivascular nitric oxide gradients normalize tumor vasculature. Nat Med. 2008 Mar; 14(3):255-7. PMID: 18278052.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  30. Ogawa K, Boucher Y, Kashiwagi S, Fukumura D, Chen D, Gerweck LE. Influence of tumor cell and stroma sensitivity on tumor response to radiation. Cancer Res. 2007 May 01; 67(9):4016-21. PMID: 17483312.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  31. Lawenda BD, Smith DE, Xu L, Niemierko A, Silverstein JR, Boucher Y, Kashiwagi S, Held KD, Jain RK, Loeffler JS, Eisenberg DM, Blumberg JB. Do the dietary supplements epigallocatechin gallate or vitamin e cause a radiomodifying response on tumors in vivo? A pilot study with murine breast carcinoma. J Soc Integr Oncol. 2007; 5(1):11-7. PMID: 17309809.
    Citations: 2     Fields:    Translation:AnimalsCells
  32. Fukumura D, Kashiwagi S, Jain RK. The role of nitric oxide in tumour progression. Nat Rev Cancer. 2006 Jul; 6(7):521-34. PMID: 16794635.
    Citations: 208     Fields:    Translation:HumansAnimalsCells
  33. Yamashita T, Shoge M, Oda E, Yamamoto Y, Giddings JC, Kashiwagi S, Suematsu M, Yamamoto J. The free-radical scavenger, edaravone, augments NO release from vascular cells and platelets after laser-induced, acute endothelial injury in vivo. Platelets. 2006 May; 17(3):201-6. PMID: 16702048.
    Citations: 4     Fields:    Translation:Animals
  34. Xu L, Cochran DM, Tong RT, Winkler F, Kashiwagi S, Jain RK, Fukumura D. Placenta growth factor overexpression inhibits tumor growth, angiogenesis, and metastasis by depleting vascular endothelial growth factor homodimers in orthotopic mouse models. Cancer Res. 2006 Apr 15; 66(8):3971-7. PMID: 16618713.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  35. Kashiwagi S, Izumi Y, Gohongi T, Demou ZN, Xu L, Huang PL, Buerk DG, Munn LL, Jain RK, Fukumura D. NO mediates mural cell recruitment and vessel morphogenesis in murine melanomas and tissue-engineered blood vessels. J Clin Invest. 2005 Jul; 115(7):1816-27. PMID: 15951843.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  36. Hagendoorn J, Padera TP, Kashiwagi S, Isaka N, Noda F, Lin MI, Huang PL, Sessa WC, Fukumura D, Jain RK. Endothelial nitric oxide synthase regulates microlymphatic flow via collecting lymphatics. Circ Res. 2004 Jul 23; 95(2):204-9. PMID: 15192027.
    Citations: 35     Fields:    Translation:Animals
  37. Kudo A, Kashiwagi S, Kajimura M, Yoshimura Y, Uchida K, Arii S, Suematsu M. Kupffer cells alter organic anion transport through multidrug resistance protein 2 in the post-cold ischemic rat liver. Hepatology. 2004 Apr; 39(4):1099-109. PMID: 15057914.
    Citations: 2     Fields:    Translation:AnimalsCells
  38. Suematsu M, Suganuma K, Kashiwagi S. Mechanistic probing of gaseous signal transduction in microcirculation. Antioxid Redox Signal. 2003 Aug; 5(4):485-92. PMID: 13678537.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  39. Kashiwagi S, Miyakoshi K, Ishimoto H, Tanaka M, Yoshimura Y. Checkmark fetal heart rate pattern associated with severe fetal hypoxia. A case report. Fetal Diagn Ther. 2003 Jul-Aug; 18(4):237-9. PMID: 12835582.
    Citations:    Fields:    Translation:Humans
  40. Kashiwagi S, Kajimura M, Yoshimura Y, Suematsu M. Nonendothelial source of nitric oxide in arterioles but not in venules: alternative source revealed in vivo by diaminofluorescein microfluorography. Circ Res. 2002 Dec 13; 91(12):e55-64. PMID: 12480826.
    Citations: 19     Fields:    Translation:AnimalsCells
  41. Kashiwagi S, Suematsu M, Wakabayashi Y, Kawada N, Tachibana M, Koizumi A, Inoue M, Ishimura Y, Kaneko A. Electrophysiological characterization of cultured hepatic stellate cells in rats. Am J Physiol. 1997 Apr; 272(4 Pt 1):G742-50. PMID: 9142904.
    Citations: 6     Fields:    Translation:AnimalsCells
  42. Suematsu M, Shimmura S, Goda N, Kashiwagi S, Wakabayashi Y, Ishimura Y. Fat-storing Ito cells: Modulatory machinery for regulation of the hepatic microcirculation?. Gastrointestinal Function, Regulation and Disturbances. 1996; (14):101-108.
  43. Suematsu M, Goda N, Sano T, Kashiwagi S, Egawa T, Shinoda Y, Ishimura Y. Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver. J Clin Invest. 1995 Nov; 96(5):2431-7. PMID: 7593631.
    Citations: 43     Fields:    Translation:Animals
  44. Goda N, Kashiwagi S, Sano T, Yuichi S, Suematsu M, Ishimura Y. Modulation of actin polymerization by carbon monoxide in Fat-storing Ito cells. Microcircul Annual. 1995; (11):87-88.
  45. Suematsu M, Kashiwagi S, Sano T, Goda N, Shinoda Y, Ishimura Y. Carbon monoxide as an endogenous modulator of hepatic vascular perfusion. Biochem Biophys Res Commun. 1994 Dec 15; 205(2):1333-7. PMID: 7802666.
    Citations: 29     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.