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Joel Francis Habener, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U19DK061251 (HABENER, JOEL F) Sep 30, 2001 - Jul 31, 2007
    NIH/NIDDK
    Program Project,Restoration of Endocrine Pancreas Funct*
    Role: Principal Investigator
  2. R21DK060125 (HABENER, JOEL F) Sep 20, 2001 - Jul 31, 2005
    NIH/NIDDK
    PANCREATIC ISLET-DERIVED STEM CELLS
    Role: Principal Investigator
  3. P30DK057521 (AVRUCH, JOSEPH) Jun 1, 2000 - Mar 31, 2020
    NIH/NIDDK
    Boston Area Diabetes Endocrinology Research Center
    Role: Co-Principal Investigator
  4. R01DK055365 (HABENER, JOEL F) Sep 16, 1999 - Jun 30, 2007
    NIH/NIDDK
    TRANSCRIPTION FACTORS AND THE ENDOCRINE PANCREAS
    Role: Principal Investigator
  5. U54HD028138 (CROWLEY, WILLIAM FRANCIS) Apr 1, 1997 - Mar 31, 2016
    NIH/NICHD
    Harvard Reproductive Endocrine Sciences Center
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Drucker DJ, Habener JF, Holst JJ. Discovery, characterization, and clinical development of the glucagon-like peptides. J Clin Invest. 2017 Dec 01; 127(12):4217-4227. PMID: 29202475.
    View in: PubMed
  2. Habener JF, Stanojevic V. Pancreas and Not Gut Mediates the GLP-1-Induced Glucoincretin Effect. Cell Metab. 2017 04 04; 25(4):757-758. PMID: 28380367.
    View in: PubMed
  3. Stanojevic V, Habener JF. Evolving function and potential of pancreatic alpha cells. Best Pract Res Clin Endocrinol Metab. 2015 Dec; 29(6):859-71. PMID: 26696515; PMCID: PMC4690008 [Available on 12/01/16].
  4. Elahi D, Ruff DA, Carlson OD, Meneilly GS, Habener JF, Egan JM. Does GLP-1 suppress its own basal secretion? Endocr Res. 2016; 41(1):16-20. PMID: 26186406.
    View in: PubMed
  5. Tomas E, Stanojevic V, McManus K, Khatri A, Everill P, Bachovchin WW, Habener JF. GLP-1(32-36)amide Pentapeptide Increases Basal Energy Expenditure and Inhibits Weight Gain in Obese Mice. Diabetes. 2015 Jul; 64(7):2409-19. PMID: 25858562; PMCID: PMC4477344.
  6. Elahi D, Angeli FS, Vakilipour A, Carlson OD, Tomas E, Egan JM, Habener JF, Shannon RP. GLP-1(32-36)amide, a novel pentapeptide cleavage product of GLP-1, modulates whole body glucose metabolism in dogs. Peptides. 2014 Sep; 59:20-4. PMID: 24937653.
    View in: PubMed
  7. Unger RH, Berglund ED, Habener JF, Cherrington AD. Dissecting the actions of widely used diabetes drugs. Nat Med. 2013 Mar; 19(3):272-3. PMID: 23467236.
    View in: PubMed
  8. Habener JF, Stanojevic V. Alpha cells come of age. Trends Endocrinol Metab. 2013 Mar; 24(3):153-63. PMID: 23260869.
    View in: PubMed
  9. Habener JF, Stanojevic V. a-cell role in ß-cell generation and regeneration. Islets. 2012 May-Jun; 4(3):188-98. PMID: 22847495; PMCID: PMC3442816.
  10. Liu Z, Stanojevic V, Brindamour LJ, Habener JF. GLP1-derived nonapeptide GLP1(28-36)amide protects pancreatic ß-cells from glucolipotoxicity. J Endocrinol. 2012 May; 213(2):143-54. PMID: 22414687; PMCID: PMC4096040.
  11. Liu Z, Stanojevic V, Avadhani S, Yano T, Habener JF. Stromal cell-derived factor-1 (SDF-1)/chemokine (C-X-C motif) receptor 4 (CXCR4) axis activation induces intra-islet glucagon-like peptide-1 (GLP-1) production and enhances beta cell survival. Diabetologia. 2011 Aug; 54(8):2067-76. PMID: 21567300; PMCID: PMC4111228.
  12. Tomas E, Wood JA, Stanojevic V, Habener JF. GLP-1-derived nonapeptide GLP-1(28-36)amide inhibits weight gain and attenuates diabetes and hepatic steatosis in diet-induced obese mice. Regul Pept. 2011 Aug 08; 169(1-3):43-8. PMID: 21549160.
    View in: PubMed
  13. Tomas E, Stanojevic V, Habener JF. GLP-1-derived nonapeptide GLP-1(28-36)amide targets to mitochondria and suppresses glucose production and oxidative stress in isolated mouse hepatocytes. Regul Pept. 2011 Apr 11; 167(2-3):177-84. PMID: 21256872.
    View in: PubMed
  14. Tomas E, Wood JA, Stanojevic V, Habener JF. Glucagon-like peptide-1(9-36)amide metabolite inhibits weight gain and attenuates diabetes and hepatic steatosis in diet-induced obese mice. Diabetes Obes Metab. 2011 Jan; 13(1):26-33. PMID: 21114600.
    View in: PubMed
  15. Li WC, Rukstalis JM, Nishimura W, Tchipashvili V, Habener JF, Sharma A, Bonner-Weir S. Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci. 2010 Aug 15; 123(Pt 16):2792-802. PMID: 20663919; PMCID: PMC2915881.
  16. Tomas E, Stanojevic V, Habener JF. GLP-1 (9-36) amide metabolite suppression of glucose production in isolated mouse hepatocytes. Horm Metab Res. 2010 Aug; 42(9):657-62. PMID: 20645222.
    View in: PubMed
  17. Liu Z, Habener JF. Wnt signaling in pancreatic islets. Adv Exp Med Biol. 2010; 654:391-419. PMID: 20217507.
    View in: PubMed
  18. Tomas E, Habener JF. Insulin-like actions of glucagon-like peptide-1: a dual receptor hypothesis. Trends Endocrinol Metab. 2010 Feb; 21(2):59-67. PMID: 20018525; PMCID: PMC4085161.
  19. Rukstalis JM, Habener JF. Neurogenin3: a master regulator of pancreatic islet differentiation and regeneration. Islets. 2009 Nov-Dec; 1(3):177-84. PMID: 21099270.
    View in: PubMed
  20. Liu Z, Habener JF. Alpha cells beget beta cells. Cell. 2009 Aug 07; 138(3):424-6. PMID: 19665963.
    View in: PubMed
  21. Liu Z, Habener JF. Stromal cell-derived factor-1 promotes survival of pancreatic beta cells by the stabilisation of beta-catenin and activation of transcription factor 7-like 2 (TCF7L2). Diabetologia. 2009 Aug; 52(8):1589-98. PMID: 19468708; PMCID: PMC4085163.
  22. Elahi D, Egan JM, Shannon RP, Meneilly GS, Khatri A, Habener JF, Andersen DK. GLP-1 (9-36) amide, cleavage product of GLP-1 (7-36) amide, is a glucoregulatory peptide. Obesity (Silver Spring). 2008 Jul; 16(7):1501-9. PMID: 18421270.
    View in: PubMed
  23. Stanojevic V, Habener JF, Holz GG, Leech CA. Cytosolic adenylate kinases regulate K-ATP channel activity in human beta-cells. Biochem Biophys Res Commun. 2008 Apr 11; 368(3):614-9. PMID: 18243136; PMCID: PMC2915763.
  24. Liu Z, Habener JF. Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation. J Biol Chem. 2008 Mar 28; 283(13):8723-35. PMID: 18216022; PMCID: PMC2417166.
  25. Yano T, Liu Z, Donovan J, Thomas MK, Habener JF. Stromal cell derived factor-1 (SDF-1)/CXCL12 attenuates diabetes in mice and promotes pancreatic beta-cell survival by activation of the prosurvival kinase Akt. Diabetes. 2007 Dec; 56(12):2946-57. PMID: 17878289.
    View in: PubMed
  26. Rukstalis JM, Habener JF. Snail2, a mediator of epithelial-mesenchymal transitions, expressed in progenitor cells of the developing endocrine pancreas. Gene Expr Patterns. 2007 Feb; 7(4):471-9. PMID: 17185046; PMCID: PMC2698037.
  27. Ubeda M, Rukstalis JM, Habener JF. Inhibition of cyclin-dependent kinase 5 activity protects pancreatic beta cells from glucotoxicity. J Biol Chem. 2006 Sep 29; 281(39):28858-64. PMID: 16887799.
    View in: PubMed
  28. Rukstalis JM, Ubeda M, Johnson MV, Habener JF. Transcription factor snail modulates hormone expression in established endocrine pancreatic cell lines. Endocrinology. 2006 Jun; 147(6):2997-3006. PMID: 16556769.
    View in: PubMed
  29. List JF, He H, Habener JF. Glucagon-like peptide-1 receptor and proglucagon expression in mouse skin. Regul Pept. 2006 May 15; 134(2-3):149-57. PMID: 16631262.
    View in: PubMed
  30. Rukstalis JM, Habener JF. Islets break off from the mainland. Nat Med. 2006 Mar; 12(3):273-4. PMID: 16520767.
    View in: PubMed
  31. Gragnoli C, Stanojevic V, Gorini A, Von Preussenthal GM, Thomas MK, Habener JF. IPF-1/MODY4 gene missense mutation in an Italian family with type 2 and gestational diabetes. Metabolism. 2005 Aug; 54(8):983-8. PMID: 16092045.
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  32. Gragnoli C, Gragnoli C, Milord E, Habener JF. Linkage study of the glucagon receptor gene with type 2 diabetes mellitus in Italians. Metabolism. 2005 Jun; 54(6):786-7. PMID: 15931615.
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  33. Lechner A, Nolan AL, Blacken RA, Habener JF. Redifferentiation of insulin-secreting cells after in vitro expansion of adult human pancreatic islet tissue. Biochem Biophys Res Commun. 2005 Feb 11; 327(2):581-8. PMID: 15629153.
    View in: PubMed
  34. Habener JF, Kemp DM, Thomas MK. Minireview: transcriptional regulation in pancreatic development. Endocrinology. 2005 Mar; 146(3):1025-34. PMID: 15604203.
    View in: PubMed
  35. Gragnoli C, Menzinger Von Preussenthal G, Habener JF. Triple genetic variation in the HNF-4alpha gene is associated with early-onset type 2 diabetes mellitus in a philippino family. Metabolism. 2004 Aug; 53(8):959-63. PMID: 15281001.
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  36. Veitenhansl M, Stegner K, Hierl FX, Dieterle C, Feldmeier H, Gutt B, Landgraf R, Garrow AP, Vileikyte L, Findlow A, Waterman C, Boulton AJ, Shankhdhar K, Shankhdhar L, Shankhdhar U, Petrova NL, Foster AV, Edmonds ME, Ferraresi R, Caravaggi C, De Giglio R, Cavaiani P, Pogliaghi I, Sommariva E, Katz IA, Harlan A, Miranda-Palma B, Prieto-Sanchez L, Armstrong DG, Bowker JH, Mizel MS, Cernea S, Wohlgelernter J, Kidron M, Modi P, Raz I, Arbit E, Nosek L, Kapitza C, Beckett P, Gelfand R, Goldberg M, Heise T, Testa MA, Turner RR, Hayes JF, Scranton RE, Simonson DC, Yang YW, Hsu YJ, Naujok O, Francini F, Jörns A, Tiedge M, Lenzen S, Abdel-Wahab YH, Marenah L, Orr DF, Shaw C, Flatt PR, Chokkalingam K, Mansell PI, Clausen P, Ekbom P, Damm P, Feldt-Rasmussen U, Nielsen B, Mathiesen ER, Feldt-Rasmussen B, Dewan S, Da Silva N, Ternan PM, Leong KS, Wilding JP, Asatiani N, Kurashvili R, Dundua M, Shelestova E, Pagava K, Ramazashvili M, Hod M, Smirnov S, Petersen JL, Justesen TI, Ringholm Nielsen L, Müller C, Højlund K, Wensaas A, Kase ET, Aas V, Rustan AC, Thoresen GH, Levin K, Beck-Nielsen H, Gaster M, Im SS, Kang SY, Kim SY, Ahn YH, Lihn AS, Schmoll D, Werner T, Kienitz A, Meyer M, Barthel A, Ailett F, Sutherland C, Walther R, Grempler R, Sasson S, Reich R, Tenenbaum T, Alpert E, Anfossi G, Russo I, Traversa M, Massucco P, Mattiello L, Doronzo G, Trovati M, Lally S, Tan CY, Owens D, Tomkin GH, Porchay I, Péan F, Bellili N, Betoulle D, Balkau B, Tichet J, Marre M, Fumeron F, Chatellier G, Alhenc-Gelas F, Nichols GA, Brown JB, Hayes RP, Bowman L, Drexel H, Saely CH, Marte T, Benzer W, Langer P, Hoefle G, Moll W, Aczel S, Karagiannis E, Lübben G, Urquhart R, Edwards G, Bruce S, Howlett HS, Cugnardey N, Turner KC, Park JS, Fiedorek FT, Avogaro A, Gallo A, Pinton P, Rizzuto R, Murphy E, Ceolotto G, Caterson I, Guy-Grand B, Hill J, Barone M, Aiello A, Allochis G, Borzì V, Cannatà F, Caronna S, D'Avanzo A, Elli R, Formoso G, Paroli A, Scardapane R, Sorichetti P, Tatti P, Viviani G, Santeusanio F, Manzella D, Grella R, Abbatecola AM, Paolisso G, Søndergaard LG, Monster TB, Johnsen SP, Olsen ML, McLaughlin JK, Sørensen HT, Lervang HH, Rungby J, Lyssenko V, Fredriksson J, Almgren P, Anevski D, Orho-Melander M, Sjögren M, Tuomi T, Groop L, Jaziri R, Aubert R, Tuomilehto J, Hu G, Jousilahti P, Peltonen M, Lindstrom J, Laina A, Alevizaki M, Philippou G, Souvatzoglou A, Anastasiou E, Alba S, Metcalf BS, Voss LD, Jeffery AN, Wilkin TJ, Glüimer C, Colagiuri S, Vistisen D, Borch-Johnsen K, Haynes A, Bower C, Bulsara MK, Jones TW, Davis EA, Mortensen HB, Hougaard P, Holl R, Swift P, Pociot F, Knip M, Hansen L, Szadkowska A, Pietrzak I, Zmyslowska A, Wyka K, Bodalski J, Holl RW, Swift R, Hougaard R, Gerstl EM, Engelsberger I, Rabl W, Rosenbauer J, Gröbe H, Hofer SE, Krause U, Dabelea D, Morgan T, Pettitt DJ, Dolan L, Mayer-Davis EJ, Pihoker C, Hillier TA, Imperatore G, Ruggiero A, Hamman RE, Stylianou A, Tentolouris N, Perrea D, Tselepis AD, Lourida E, Kitsou E, Katsilambros N, Vedovato M, Dodesini AR, Lepore G, Tiengo A, Trevisan R, Penno G, Miccoli R, Pucci L, Lucchesi D, Bandinelli S, Fotino C, Triscornia S, Baldassari E, Del Prato S, Reboldi P, Santeusanio E, Fuller J, Langham RG, Gow RM, Zhang Y, Kelly DJ, Christensen PK, Parving HH, Gilbert RE, Chibalin AV, Zhong Z, Kotova O, Davidescu A, Ehrén I, Ekberg K, Wahren J, Wassef L, Buckley AJ, Rooney KB, Briody J, Thompson M, Ozanne SE, Thompson CH, Chamson-Reig A, Summers K, Arany EJ, Hill DJ, Solerte SB, Gazzaruso C, Locatelli E, Precerutti S, Schifino N, Ferrari E, Fioravanti M, Phenekos CV, Ginis A, Fragaki I, Chalkiadaki M, Tzioras C, Powell LA, McGuire GM, Jewhurst V, Trimble ER, Rasmussen BM, Vessby B, Uusitupa M, Berglund L, Pedersen E, Riccardi G, Rivellese AA, Tapsell L, Hermansen K, da Silva Xavier G, Rutter J, Rutter GA, Briaud IM, Lingohr MK, Dickson LM, McCuaig JR, Lawrence JC, Rhodes CJ, Wikstrom JD, Katzman SM, Shirihai OS, Yang J, Deng S, Wang X, Hessner MJ, Wu J, Wong RK, et al. 40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004. Diabetologia. 2004 Aug; 47(Suppl 1):A1-A464. PMID: 27770180.
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  37. Ogawa N, List JF, Habener JF, Maki T. Cure of overt diabetes in NOD mice by transient treatment with anti-lymphocyte serum and exendin-4. Diabetes. 2004 Jul; 53(7):1700-5. PMID: 15220193.
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  38. List JF, Habener JF. Glucagon-like peptide 1 agonists and the development and growth of pancreatic beta-cells. Am J Physiol Endocrinol Metab. 2004 Jun; 286(6):E875-81. PMID: 15140754.
    View in: PubMed
  39. Schmitt-Ney M, Habener JF. Cell-density-dependent regulation of actin gene expression due to changes in actin treadmilling. Exp Cell Res. 2004 Apr 15; 295(1):236-44. PMID: 15051506.
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  40. Stanojevic V, Habener JF, Thomas MK. Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300. Endocrinology. 2004 Jun; 145(6):2918-28. PMID: 15001545.
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  41. Abraham EJ, Kodama S, Lin JC, Ubeda M, Faustman DL, Habener JF. Human pancreatic islet-derived progenitor cell engraftment in immunocompetent mice. Am J Pathol. 2004 Mar; 164(3):817-30. PMID: 14982836; PMCID: PMC1613272.
  42. Lechner A, Yang YG, Blacken RA, Wang L, Nolan AL, Habener JF. No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes. 2004 Mar; 53(3):616-23. PMID: 14988245.
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  43. Ubeda M, Kemp DM, Habener JF. Glucose-induced expression of the cyclin-dependent protein kinase 5 activator p35 involved in Alzheimer's disease regulates insulin gene transcription in pancreatic beta-cells. Endocrinology. 2004 Jun; 145(6):3023-31. PMID: 14976144.
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  44. Habener JF. A perspective on pancreatic stem/progenitor cells. Pediatr Diabetes. 2004; 5 Suppl 2:29-37. PMID: 15601372.
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  45. Meneilly GS, Greig N, Tildesley H, Habener JF, Egan JM, Elahi D. Effects of 3 months of continuous subcutaneous administration of glucagon-like peptide 1 in elderly patients with type 2 diabetes. Diabetes Care. 2003 Oct; 26(10):2835-41. PMID: 14514588.
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  46. Leech CA, Habener JF. Regulation of glucagon-like peptide-1 receptor and calcium-sensing receptor signaling by L-histidine. Endocrinology. 2003 Nov; 144(11):4851-8. PMID: 12959987.
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  47. Ubeda M, Habener JF. CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation. J Biol Chem. 2003 Oct 17; 278(42):40514-20. PMID: 12876286.
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  48. Lechner A, Habener JF. Bone marrow stem cells find a path to the pancreas. Nat Biotechnol. 2003 Jul; 21(7):755-6. PMID: 12833093.
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  49. Kemp DM, Lin JC, Habener JF. Regulation of Pax4 paired homeodomain gene by neuron-restrictive silencer factor. J Biol Chem. 2003 Sep 12; 278(37):35057-62. PMID: 12829700.
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  50. List JF, Habener JF. Defective melanocortin 4 receptors in hyperphagia and morbid obesity. N Engl J Med. 2003 Mar 20; 348(12):1160-3. PMID: 12646673.
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  51. Kemp DM, Thomas MK, Habener JF. Developmental aspects of the endocrine pancreas. Rev Endocr Metab Disord. 2003 Mar; 4(1):5-17. PMID: 12618555.
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  52. Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Ehlers MR, Egan JM, Elahi D. Effect of glucagon-like peptide 1 (7-36 amide) on insulin-mediated glucose uptake in patients with type 1 diabetes. Diabetes Care. 2003 Mar; 26(3):837-42. PMID: 12610046.
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  53. Lechner A, Habener JF. Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus. Am J Physiol Endocrinol Metab. 2003 Feb; 284(2):E259-66. PMID: 12531740.
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  54. Andreassen OA, Dedeoglu A, Stanojevic V, Hughes DB, Browne SE, Leech CA, Ferrante RJ, Habener JF, Beal MF, Thomas MK. Huntington's disease of the endocrine pancreas: insulin deficiency and diabetes mellitus due to impaired insulin gene expression. Neurobiol Dis. 2002 Dec; 11(3):410-24. PMID: 12586550.
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  55. Kemp DM, Lin JC, Ubeda M, Habener JF. NRSF/REST confers transcriptional repression of the GPR10 gene via a putative NRSE/RE-1 located in the 5' promoter region. FEBS Lett. 2002 Nov 06; 531(2):193-8. PMID: 12417311.
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  56. Habener JF. The Role of Pancreatic Duodenum Homeobox Protein-1 in the Development of Diabetes Mellitus. Drug News Perspect. 2002 Oct; 15(8):491-497. PMID: 12677187.
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  57. Kemp DM, Habener JF. Synergistic effect of dimethyl sulfoxide on glucagon-like peptide 1 (GLP-1)-stimulated insulin secretion and gene transcription in INS-1 cells: characterization and implications. Biochem Pharmacol. 2002 Aug 15; 64(4):689-97. PMID: 12167488.
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  58. Egan JM, Meneilly GS, Habener JF, Elahi D. Glucagon-like peptide-1 augments insulin-mediated glucose uptake in the obese state. J Clin Endocrinol Metab. 2002 Aug; 87(8):3768-73. PMID: 12161508.
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  59. Abraham EJ, Leech CA, Lin JC, Zulewski H, Habener JF. Insulinotropic hormone glucagon-like peptide-1 differentiation of human pancreatic islet-derived progenitor cells into insulin-producing cells. Endocrinology. 2002 Aug; 143(8):3152-61. PMID: 12130581.
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  60. Kemp DM, Ubeda M, Habener JF. Identification and functional characterization of melatonin Mel 1a receptors in pancreatic beta cells: potential role in incretin-mediated cell function by sensitization of cAMP signaling. Mol Cell Endocrinol. 2002 Jun 14; 191(2):157-66. PMID: 12062899.
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  61. Lechner A, Leech CA, Abraham EJ, Nolan AL, Habener JF. Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter. Biochem Biophys Res Commun. 2002 May 03; 293(2):670-4. PMID: 12054520.
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  62. Hussain MA, Miller CP, Habener JF. Brn-4 transcription factor expression targeted to the early developing mouse pancreas induces ectopic glucagon gene expression in insulin-producing beta cells. J Biol Chem. 2002 May 03; 277(18):16028-32. PMID: 11834725.
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  63. Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Gingerich R, Egan JM, Elahi D. Glucagon-like peptide-1 (7-37) augments insulin-mediated glucose uptake in elderly patients with diabetes. J Gerontol A Biol Sci Med Sci. 2001 Nov; 56(11):M681-5. PMID: 11682575.
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  64. Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Gingerich R, Egan JM, Finegood DT, Elahi D. Effect of glucagon-like peptide 1 on non-insulin-mediated glucose uptake in the elderly patient with diabetes. Diabetes Care. 2001 Nov; 24(11):1951-6. PMID: 11679463.
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  65. Korosi J, McIntosh CH, Pederson RA, Demuth HU, Habener JF, Gingerich R, Egan JM, Elahi D, Meneilly GS. Effect of aging and diabetes on the enteroinsular axis. J Gerontol A Biol Sci Med Sci. 2001 Sep; 56(9):M575-9. PMID: 11524451.
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  66. Maytin EV, Ubeda M, Lin JC, Habener JF. Stress-inducible transcription factor CHOP/gadd153 induces apoptosis in mammalian cells via p38 kinase-dependent and -independent mechanisms. Exp Cell Res. 2001 Jul 15; 267(2):193-204. PMID: 11426938.
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  67. Thomas MK, Devon ON, Lee JH, Peter A, Schlosser DA, Tenser MS, Habener JF. Development of diabetes mellitus in aging transgenic mice following suppression of pancreatic homeoprotein IDX-1. J Clin Invest. 2001 Jul; 108(2):319-29. PMID: 11457885; PMCID: PMC203024.
  68. Heller RS, Stoffers DA, Bock T, Svenstrup K, Jensen J, Horn T, Miller CP, Habener JF, Madsen OD, Serup P. Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas. Diabetes. 2001 Jul; 50(7):1553-61. PMID: 11423476.
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  69. Meneilly GS, McIntosh CH, Pederson RA, Habener JF, Gingerich R, Egan JM, Elahi D. Glucagon-like peptide-1 (7-37) augments insulin release in elderly patients with diabetes. Diabetes Care. 2001 May; 24(5):964-5. PMID: 11347771.
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  70. Zulewski H, Abraham EJ, Gerlach MJ, Daniel PB, Moritz W, Müller B, Vallejo M, Thomas MK, Habener JF. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes. 2001 Mar; 50(3):521-33. PMID: 11246871.
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  71. Kemp DM, Habener JF. Insulinotropic hormone glucagon-like peptide 1 (GLP-1) activation of insulin gene promoter inhibited by p38 mitogen-activated protein kinase. Endocrinology. 2001 Mar; 142(3):1179-87. PMID: 11181533.
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  72. Thomas MK, Lee JH, Rastalsky N, Habener JF. Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells. Endocrinology. 2001 Mar; 142(3):1033-40. PMID: 11181516.
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  73. Thomas MK, Lee JH, Rastalsky N, Habener JF. Hedgehog Signaling Regulation of Homeodomain Protein Islet Duodenum Homeobox-1 Expression in Pancreatic ß-Cells. Endocrinology. 2001 Mar 01; 142(3):1033-1040. PMID: 28204385.
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  74. Daniel PB, Kieffer TJ, Leech CA, Habener JF. Novel alternatively spliced exon in the extracellular ligand-binding domain of the pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1R) selectively increases ligand affinity and alters signal transduction coupling during spermatogenesis. J Biol Chem. 2001 Apr 20; 276(16):12938-44. PMID: 11278585.
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  75. Müller B, White JC, Nylén ES, Snider RH, Becker KL, Habener JF. Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis. J Clin Endocrinol Metab. 2001 Jan; 86(1):396-404. PMID: 11232031.
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  76. Moritz W, Leech CA, Ferrer J, Habener JF. Regulated expression of adenosine triphosphate-sensitive potassium channel subunits in pancreatic beta-cells. Endocrinology. 2001 Jan; 142(1):129-38. PMID: 11145575.
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  77. Moritz W, Leech CA, Ferrer J, Habener JF. Regulated Expression of Adenosine Triphosphate-Sensitive Potassium Channel Subunits in Pancreatic ß-Cells* * This work was supported in part by USPHS Grant DK-30834. Endocrinology. 2001 Jan 01; 142(1):129-138. PMID: 28201262.
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  78. Schmitt-Ney M, Habener JF. CHOP/GADD153 gene expression response to cellular stresses inhibited by prior exposure to ultraviolet light wavelength band C (UVC). Inhibitory sequence mediating the UVC response localized to exon 1. J Biol Chem. 2000 Dec 29; 275(52):40839-45. PMID: 11010973.
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  79. Ubeda M, Habener JF. CHOP gene expression in response to endoplasmic-reticular stress requires NFY interaction with different domains of a conserved DNA-binding element. Nucleic Acids Res. 2000 Dec 15; 28(24):4987-97. PMID: 11121490; PMCID: PMC115245.
  80. Thomas MK, Rastalsky N, Lee JH, Habener JF. Hedgehog signaling regulation of insulin production by pancreatic beta-cells. Diabetes. 2000 Dec; 49(12):2039-47. PMID: 11118005.
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  81. Leech CA, Holz GG, Chepurny O, Habener JF. Expression of cAMP-regulated guanine nucleotide exchange factors in pancreatic beta-cells. Biochem Biophys Res Commun. 2000 Nov 11; 278(1):44-7. PMID: 11071853; PMCID: PMC2924611.
  82. Daniel PB, Rohrbach L, Habener JF. Novel cyclic adenosine 3',5'-monophosphate (cAMP) response element modulator theta isoforms expressed by two newly identified cAMP-responsive promoters active in the testis. Endocrinology. 2000 Nov; 141(11):3923-30. PMID: 11089521.
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  83. Daniel PB, Rohrbach L, Habener JF. Novel Cyclic Adenosine 3',5'-Monophosphate (cAMP) Response Element Modulator ? Isoforms Expressed by Two Newly Identified cAMP-Responsive Promoters Active in the Testis**This work was supported in part by USPHS Grant DK-25532. Endocrinology. 2000 Nov 01; 141(11):3923-3930. PMID: 28201056.
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  84. Clocquet AR, Egan JM, Stoffers DA, Muller DC, Wideman L, Chin GA, Clarke WL, Hanks JB, Habener JF, Elahi D. Impaired insulin secretion and increased insulin sensitivity in familial maturity-onset diabetes of the young 4 (insulin promoter factor 1 gene). Diabetes. 2000 Nov; 49(11):1856-64. PMID: 11078452.
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  85. Lewis JT, Dayanandan B, Habener JF, Kieffer TJ. Glucose-dependent insulinotropic polypeptide confers early phase insulin release to oral glucose in rats: demonstration by a receptor antagonist. Endocrinology. 2000 Oct; 141(10):3710-6. PMID: 11014226.
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  86. Hussain MA, Daniel PB, Habener JF. Glucagon stimulates expression of the inducible cAMP early repressor and suppresses insulin gene expression in pancreatic beta-cells. Diabetes. 2000 Oct; 49(10):1681-90. PMID: 11016452.
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  87. Holz GG, Leech CA, Habener JF. Insulinotropic toxins as molecular probes for analysis of glucagon-likepeptide-1 receptor-mediated signal transduction in pancreatic beta-cells. Biochimie. 2000 Sep-Oct; 82(9-10):915-26. PMID: 11086221; PMCID: PMC2928854.
  88. Hussain MA, Habener JF. Glucagon-like peptide 1 increases glucose-dependent activity of the homeoprotein IDX-1 transactivating domain in pancreatic beta-cells. Biochem Biophys Res Commun. 2000 Aug 11; 274(3):616-9. PMID: 10924326.
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  89. Habener JF. Citation for the 2000 Robert H. Williams Distinguished Leadership Award of The Endocrine Society to Dr. William W. Chin. Endocr Rev. 2000 Aug; 21(4):448. PMID: 10950162.
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  90. Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM. Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas. Diabetes. 2000 May; 49(5):741-8. PMID: 10905482.
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  91. Daniel PB, Habener JF. Pituitary adenylate cyclase-activating polypeptide gene expression regulated by a testis-specific promoter in germ cells during spermatogenesis. Endocrinology. 2000 Mar; 141(3):1218-27. PMID: 10698199.
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  92. Kieffer TJ, Habener JF. The adipoinsular axis: effects of leptin on pancreatic beta-cells. Am J Physiol Endocrinol Metab. 2000 Jan; 278(1):E1-E14. PMID: 10644531.
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  93. Xu G, Stoffers DA, Habener JF, Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes. 1999 Dec; 48(12):2270-6. PMID: 10580413.
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  94. Maytin EV, Lin JC, Krishnamurthy R, Batchvarova N, Ron D, Mitchell PJ, Habener JF. Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2. Dev Biol. 1999 Dec 01; 216(1):164-81. PMID: 10588870.
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  95. Thomas MK, Yao KM, Tenser MS, Wong GG, Habener JF. Bridge-1, a novel PDZ-domain coactivator of E2A-mediated regulation of insulin gene transcription. Mol Cell Biol. 1999 Dec; 19(12):8492-504. PMID: 10567574; PMCID: PMC84960.
  96. Kieffer TJ, Habener JF. The glucagon-like peptides. Endocr Rev. 1999 Dec; 20(6):876-913. PMID: 10605628.
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  97. Stoffers DA, Heller RS, Miller CP, Habener JF. Developmental Expression of the Homeodomain Protein IDX-1 in Mice Transgenic for an IDX-1 Promoter/lacZ Transcriptional Reporter1. Endocrinology. 1999 Nov 01; 140(11):5374-5381. PMID: 28204265.
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  98. Ubeda M, Vallejo M, Habener JF. CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Mol Cell Biol. 1999 Nov; 19(11):7589-99. PMID: 10523647; PMCID: PMC84780.
  99. Stoffers DA, Heller RS, Miller CP, Habener JF. Developmental expression of the homeodomain protein IDX-1 in mice transgenic for an IDX-1 promoter/lacZ transcriptional reporter. Endocrinology. 1999 Nov; 140(11):5374-81. PMID: 10537169.
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  100. Hani EH, Stoffers DA, Chèvre JC, Durand E, Stanojevic V, Dina C, Habener JF, Froguel P. Defective mutations in the insulin promoter factor-1 (IPF-1) gene in late-onset type 2 diabetes mellitus. J Clin Invest. 1999 Nov; 104(9):R41-8. PMID: 10545531; PMCID: PMC409821.
  101. Hussain MA, Habener JF. Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator. J Biol Chem. 1999 Oct 08; 274(41):28950-7. PMID: 10506141.
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  102. Ubeda M, Schmitt-Ney M, Ferrer J, Habener JF. CHOP/GADD153 and methionyl-tRNA synthetase (MetRS) genes overlap in a conserved region that controls mRNA stability. Biochem Biophys Res Commun. 1999 Aug 19; 262(1):31-8. PMID: 10448063.
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  104. Holz GG, Leech CA, Heller RS, Castonguay M, Habener JF. cAMP-dependent mobilization of intracellular Ca2+ stores by activation of ryanodine receptors in pancreatic beta-cells. A Ca2+ signaling system stimulated by the insulinotropic hormone glucagon-like peptide-1-(7-37). J Biol Chem. 1999 May 14; 274(20):14147-56. PMID: 10318832; PMCID: PMC3508791.
  105. Sharma A, Zangen DH, Reitz P, Taneja M, Lissauer ME, Miller CP, Weir GC, Habener JF, Bonner-Weir S. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes. 1999 Mar; 48(3):507-13. PMID: 10078550.
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  106. Seufert J, Kieffer TJ, Leech CA, Holz GG, Moritz W, Ricordi C, Habener JF. Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab. 1999 Feb; 84(2):670-6. PMID: 10022436; PMCID: PMC2927866.
  107. Leech CA, Castonguay MA, Habener JF. Expression of adenylyl cyclase subtypes in pancreatic beta-cells. Biochem Biophys Res Commun. 1999 Jan 27; 254(3):703-6. PMID: 9920805.
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  108. Seufert J, Kieffer TJ, Habener JF. Leptin inhibits insulin gene transcription and reverses hyperinsulinemia in leptin-deficient ob/ob mice. Proc Natl Acad Sci U S A. 1999 Jan 19; 96(2):674-9. PMID: 9892692; PMCID: PMC15195.
  109. Walker WH, Delfino FJ, Habener JF. RNA processing and the control of spermatogenesis. Front Horm Res. 1999; 25:34-58. PMID: 10941401.
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  110. Coven E, Ni Y, Widnell KL, Chen J, Walker WH, Habener JF, Nestler EJ. Cell type-specific regulation of CREB gene expression: mutational analysis of CREB promoter activity. J Neurochem. 1998 Nov; 71(5):1865-74. PMID: 9798910.
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  111. Holz GG, Habener JF. Black widow spider alpha-latrotoxin: a presynaptic neurotoxin that shares structural homology with the glucagon-like peptide-1 family of insulin secretagogic hormones. Comp Biochem Physiol B Biochem Mol Biol. 1998 Oct; 121(2):177-84. PMID: 9972293; PMCID: PMC2924186.
  112. Daniel PB, Habener JF. Cyclical alternative exon splicing of transcription factor cyclic adenosine monophosphate response element-binding protein (CREB) messenger ribonucleic acid during rat spermatogenesis. Endocrinology. 1998 Sep; 139(9):3721-9. PMID: 9724023.
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  113. Walker WH, Daniel PB, Habener JF. Inducible cAMP early repressor ICER down-regulation of CREB gene expression in Sertoli cells. Mol Cell Endocrinol. 1998 Aug 25; 143(1-2):167-78. PMID: 9806361.
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  114. Heller RS, Stoffers DA, Hussain MA, Miller CP, Habener JF. Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum. Gastroenterology. 1998 Aug; 115(2):381-7. PMID: 9679043.
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  115. Ryan AS, Egan JM, Habener JF, Elahi D. Insulinotropic hormone glucagon-like peptide-1-(7-37) appears not to augment insulin-mediated glucose uptake in young men during euglycemia. J Clin Endocrinol Metab. 1998 Jul; 83(7):2399-404. PMID: 9661618.
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  116. Leech CA, Habener JF. A role for Ca2+-sensitive nonselective cation channels in regulating the membrane potential of pancreatic beta-cells. Diabetes. 1998 Jul; 47(7):1066-73. PMID: 9648830.
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  117. Stoffers DA, Stanojevic V, Habener JF. Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein. J Clin Invest. 1998 Jul 01; 102(1):232-41. PMID: 9649577; PMCID: PMC509085.
  118. Seufert J, Weir GC, Habener JF. Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus. J Clin Invest. 1998 Jun 01; 101(11):2528-39. PMID: 9616224; PMCID: PMC508842.
  119. Chèvre JC, Hani EH, Stoffers DA, Habener JF, Froguel P. Insulin promoter factor 1 gene is not a major cause of maturity-onset diabetes of the young in French Caucasians. Diabetes. 1998 May; 47(5):843-4. PMID: 9588460.
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  120. Hua QX, Jia WH, Bullock BP, Habener JF, Weiss MA. Transcriptional activator-coactivator recognition: nascent folding of a kinase-inducible transactivation domain predicts its structure on coactivator binding. Biochemistry. 1998 Apr 28; 37(17):5858-66. PMID: 9558319.
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  121. Bodor J, Habener JF. Role of transcriptional repressor ICER in cyclic AMP-mediated attenuation of cytokine gene expression in human thymocytes. J Biol Chem. 1998 Apr 17; 273(16):9544-51. PMID: 9545284.
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  122. Bullock BP, Habener JF. Phosphorylation of the cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding affinity, conformation, and increases net charge. Biochemistry. 1998 Mar 17; 37(11):3795-809. PMID: 9521699.
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  123. Maytin EV, Habener JF. Transcription factors C/EBP alpha, C/EBP beta, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo. J Invest Dermatol. 1998 Mar; 110(3):238-46. PMID: 9506442.
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  124. Habener JF, Stoffers DA. A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus. Proc Assoc Am Physicians. 1998 Jan-Feb; 110(1):12-21. PMID: 9460079.
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  125. Daniel PB, Walker WH, Habener JF. Cyclic AMP signaling and gene regulation. Annu Rev Nutr. 1998; 18:353-83. PMID: 9706229.
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  126. Hussain MA, Lee J, Miller CP, Habener JF. POU domain transcription factor brain 4 confers pancreatic alpha-cell-specific expression of the proglucagon gene through interaction with a novel proximal promoter G1 element. Mol Cell Biol. 1997 Dec; 17(12):7186-94. PMID: 9372951; PMCID: PMC232576.
  127. Lu M, Seufert J, Habener JF. Pancreatic beta-cell-specific repression of insulin gene transcription by CCAAT/enhancer-binding protein beta. Inhibitory interactions with basic helix-loop-helix transcription factor E47. J Biol Chem. 1997 Nov 07; 272(45):28349-59. PMID: 9353292.
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  128. Stoffers DA, Ferrer J, Clarke WL, Habener JF. Early-onset type-II diabetes mellitus (MODY4) linked to IPF1. Nat Genet. 1997 Oct; 17(2):138-9. PMID: 9326926.
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  129. Ubeda M, Habener JF. The large subunit of the DNA replication complex C (DSEB/RF-C140) cleaved and inactivated by caspase-3 (CPP32/YAMA) during Fas-induced apoptosis. J Biol Chem. 1997 Aug 01; 272(31):19562-8. PMID: 9235961.
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  130. Leech CA, Habener JF. Insulinotropic glucagon-like peptide-1-mediated activation of non-selective cation currents in insulinoma cells is mimicked by maitotoxin. J Biol Chem. 1997 Jul 18; 272(29):17987-93. PMID: 9218425.
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  131. Kieffer TJ, Heller RS, Leech CA, Holz GG, Habener JF. Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreatic beta-cells. Diabetes. 1997 Jun; 46(6):1087-93. PMID: 9166685; PMCID: PMC2940064.
  132. Stoffers DA, Thomas MK, Habener JF. Homeodomain protein IDX-1: a master regulator of pancreas development and insulin gene expression. Trends Endocrinol Metab. 1997 May-Jun; 8(4):145-51. PMID: 18406800.
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  133. Heller RS, Kieffer TJ, Habener JF. Insulinotropic glucagon-like peptide I receptor expression in glucagon-producing alpha-cells of the rat endocrine pancreas. Diabetes. 1997 May; 46(5):785-91. PMID: 9133545.
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  134. Zangen DH, Bonner-Weir S, Lee CH, Latimer JB, Miller CP, Habener JF, Weir GC. Reduced insulin, GLUT2, and IDX-1 in beta-cells after partial pancreatectomy. Diabetes. 1997 Feb; 46(2):258-64. PMID: 9000703.
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  135. Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet. 1997 Jan; 15(1):106-10. PMID: 8988180.
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  136. Leech CA, Holz GG, Habener JF. Signal transduction of PACAP and GLP-1 in pancreatic beta cells. Ann N Y Acad Sci. 1996 Dec 26; 805:81-92; discussion 92-3. PMID: 8993395; PMCID: PMC3505615.
  137. Lyle RE, Habener JF, McGehee RE. Antisense oligonucleotides to differentiation-specific element binding protein (DSEB) mRNA inhibit adipocyte differentiation. Biochem Biophys Res Commun. 1996 Nov 21; 228(3):709-15. PMID: 8941343.
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  138. Kieffer TJ, Heller RS, Unson CG, Weir GC, Habener JF. Distribution of glucagon receptors on hormone-specific endocrine cells of rat pancreatic islets. Endocrinology. 1996 Nov; 137(11):5119-25. PMID: 8895386.
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  139. Walker WH, Girardet C, Habener JF. Alternative exon splicing controls a translational switch from activator to repressor isoforms of transcription factor CREB during spermatogenesis. J Biol Chem. 1996 Aug 16; 271(33):20145-1050. PMID: 8702738.
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  140. Kieffer TJ, Heller RS, Habener JF. Leptin receptors expressed on pancreatic beta-cells. Biochem Biophys Res Commun. 1996 Jul 16; 224(2):522-7. PMID: 8702421.
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  141. Lu M, Miller C, Habener JF. Functional regions of the homeodomain protein IDX-1 required for transactivation of the rat somatostatin gene. Endocrinology. 1996 Jul; 137(7):2959-67. PMID: 8770920.
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  142. Bullock BP, Heller RS, Habener JF. Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology. 1996 Jul; 137(7):2968-78. PMID: 8770921.
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  143. Girardet C, Walker WH, Habener JF. An alternatively spliced polycistronic mRNA encoding cyclic adenosine 3',5'-monophosphate (cAMP)-responsive transcription factor CREB (cAMP response element-binding protein) in human testis extinguishes expression of an internally translated inhibitor CREB isoform. Mol Endocrinol. 1996 Jul; 10(7):879-891. PMID: 8813728.
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  144. Heller RS, Kieffer TJ, Habener JF. Point mutations in the first and third intracellular loops of the glucagon-like peptide-1 receptor alter intracellular signaling. Biochem Biophys Res Commun. 1996 Jun 25; 223(3):624-32. PMID: 8687446.
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  145. Walker WH, Habener JF. Role of transcription factors CREB and CREM in cAMP-regulated transcription during spermatogenesis. Trends Endocrinol Metab. 1996 May-Jun; 7(4):133-8. PMID: 18406739.
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  146. Bodor J, Spetz AL, Strominger JL, Habener JF. cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes. Proc Natl Acad Sci U S A. 1996 Apr 16; 93(8):3536-41. PMID: 8622971; PMCID: PMC39645.
  147. Widnell KL, Chen JS, Iredale PA, Walker WH, Duman RS, Habener JF, Nestler EJ. Transcriptional regulation of CREB (cyclic AMP response element-binding protein) expression in CATH.a cells. J Neurochem. 1996 Apr; 66(4):1770-3. PMID: 8627337.
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  148. Ubeda M, Wang XZ, Zinszner H, Wu I, Habener JF, Ron D. Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Mol Cell Biol. 1996 Apr; 16(4):1479-89. PMID: 8657121; PMCID: PMC231132.
  149. Bodor J, Walker W, Flemington E, Spetz AL, Habener JF. Modulation of Tax and PKA-mediated expression of HTLV-I promoter via cAMP response element binding and modulator proteins CREB and CREM. FEBS Lett. 1995 Dec 27; 377(3):413-8. PMID: 8549766.
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  150. Vallejo M, Miller CP, Beckman W, Habener JF. Repression of somatostatin gene transcription mediated by two promoter silencer elements. Mol Cell Endocrinol. 1995 Aug 30; 113(1):61-72. PMID: 8674814.
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  151. Walker WH, Fucci L, Habener JF. Expression of the gene encoding transcription factor cyclic adenosine 3',5'-monophosphate (cAMP) response element-binding protein (CREB): regulation by follicle-stimulating hormone-induced cAMP signaling in primary rat Sertoli cells. Endocrinology. 1995 Aug; 136(8):3534-45. PMID: 7628390.
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  152. Holz GG, Leech CA, Habener JF. Activation of a cAMP-regulated Ca(2+)-signaling pathway in pancreatic beta-cells by the insulinotropic hormone glucagon-like peptide-1. J Biol Chem. 1995 Jul 28; 270(30):17749-57. PMID: 7543091; PMCID: PMC3505614.
  153. Leech CA, Holz GG, Habener JF. Pituitary adenylate cyclase-activating polypeptide induces the voltage-independent activation of inward membrane currents and elevation of intracellular calcium in HIT-T15 insulinoma cells. Endocrinology. 1995 Apr; 136(4):1530-6. PMID: 7895663; PMCID: PMC2955406.
  154. McGehee RE, Habener JF. Differentiation-specific element binding protein (DSEB) binds to a defined element in the promoter of the angiotensinogen gene required for the irreversible induction of gene expression during differentiation of 3T3-L1 adipoblasts to adipocytes. Mol Endocrinol. 1995 Apr; 9(4):487-501. PMID: 7659092.
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  155. Vallejo M, Gosse ME, Beckman W, Habener JF. Impaired cyclic AMP-dependent phosphorylation renders CREB a repressor of C/EBP-induced transcription of the somatostatin gene in an insulinoma cell line. Mol Cell Biol. 1995 Jan; 15(1):415-24. PMID: 7799950; PMCID: PMC231983.
  156. Habener JF, Miller CP, Vallejo M. cAMP-dependent regulation of gene transcription by cAMP response element-binding protein and cAMP response element modulator. Vitam Horm. 1995; 51:1-57. PMID: 7483321.
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  157. Walker WH, Sanborn BM, Habener JF. An isoform of transcription factor CREM expressed during spermatogenesis lacks the phosphorylation domain and represses cAMP-induced transcription. Proc Natl Acad Sci U S A. 1994 Dec 20; 91(26):12423-7. PMID: 7809053; PMCID: PMC45450.
  158. Leech CA, Holz GG, Habener JF. Voltage-independent calcium channels mediate slow oscillations of cytosolic calcium that are glucose dependent in pancreatic beta-cells. Endocrinology. 1994 Jul; 135(1):365-72. PMID: 8013370; PMCID: PMC2922863.
  159. Yun Y, Hoeffler JP, Habener JF. Cyclic AMP-responsive transcriptional activation domain of CREB-327 involves interdependent phosphorylated subdomains. EMBO J. 1994 Jun 01; 13(11):2736. PMID: 8013471; PMCID: PMC395148.
  160. Elahi D, McAloon-Dyke M, Fukagawa NK, Meneilly GS, Sclater AL, Minaker KL, Habener JF, Andersen DK. The insulinotropic actions of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (7-37) in normal and diabetic subjects. Regul Pept. 1994 Apr 14; 51(1):63-74. PMID: 8036284.
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  161. Miller CP, McGehee RE, Habener JF. IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. EMBO J. 1994 Mar 01; 13(5):1145-56. PMID: 7907546; PMCID: PMC394923.
  162. Habener JF. The incretin notion and its relevance to diabetes. Endocrinol Metab Clin North Am. 1993 Dec; 22(4):775-94. PMID: 8125072.
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  163. Miller CP, Lin JC, Habener JF. Transcription of the rat glucagon gene by the cyclic AMP response element-binding protein CREB is modulated by adjacent CREB-associated proteins. Mol Cell Biol. 1993 Nov; 13(11):7080-90. PMID: 8413297; PMCID: PMC364769.
  164. Meyer TE, Habener JF. Cyclic adenosine 3',5'-monophosphate response element binding protein (CREB) and related transcription-activating deoxyribonucleic acid-binding proteins. Endocr Rev. 1993 Jun; 14(3):269-90. PMID: 8319595.
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  165. Vallejo M, Ron D, Miller CP, Habener JF. C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc Natl Acad Sci U S A. 1993 May 15; 90(10):4679-83. PMID: 8506317; PMCID: PMC46576.
  166. McGehee RE, Ron D, Brasier AR, Habener JF. Differentiation-specific element: a cis-acting developmental switch required for the sustained transcriptional expression of the angiotensinogen gene during hormonal-induced differentiation of 3T3-L1 fibroblasts to adipocytes. Mol Endocrinol. 1993 Apr; 7(4):551-60. PMID: 7684818.
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  167. Meyer TE, Waeber G, Lin J, Beckmann W, Habener JF. The promoter of the gene encoding 3',5'-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription. Endocrinology. 1993 Feb; 132(2):770-80. PMID: 8381074.
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  168. Holz GG, Kühtreiber WM, Habener JF. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature. 1993 Jan 28; 361(6410):362-5. PMID: 8381211; PMCID: PMC2916679.
  169. Hendrick GK, Gjinovci A, Baxter LA, Mojsov S, Wollheim CB, Habener JF, Weir GC. Glucagon-like peptide-I-(7-37) suppresses hyperglycemia in rats. Metabolism. 1993 Jan; 42(1):1-6. PMID: 8446036.
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  170. Meyer TE, Habener JF. Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes. Nucleic Acids Res. 1992 Nov 25; 20(22):6106. PMID: 1461747; PMCID: PMC334485.
  171. Waeber G, Habener JF. Novel testis germ cell-specific transcript of the CREB gene contains an alternatively spliced exon with multiple in-frame stop codons. Endocrinology. 1992 Oct; 131(4):2010-5. PMID: 1396344.
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  172. Holz GG, Habener JF. Signal transduction crosstalk in the endocrine system: pancreatic beta-cells and the glucose competence concept. Trends Biochem Sci. 1992 Oct; 17(10):388-93. PMID: 1455507; PMCID: PMC2925193.
  173. Fehmann HC, Habener JF. Insulinotropic glucagonlike peptide-I(7-37)/(7-36)amide A new incretin hormone. Trends Endocrinol Metab. 1992 Jul; 3(5):158-63. PMID: 18407095.
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  174. Vallejo M, Penchuk L, Habener JF. Somatostatin gene upstream enhancer element activated by a protein complex consisting of CREB, Isl-1-like, and alpha-CBF-like transcription factors. J Biol Chem. 1992 Jun 25; 267(18):12876-84. PMID: 1352292.
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  175. Vallejo M, Miller CP, Habener JF. Somatostatin gene transcription regulated by a bipartite pancreatic islet D-cell-specific enhancer coupled synergetically to a cAMP response element. J Biol Chem. 1992 Jun 25; 267(18):12868-75. PMID: 1352291.
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  176. Fehmann HC, Habener JF. Galanin inhibits proinsulin gene expression stimulated by the insulinotropic hormone glucagon-like peptide-I(7-37) in mouse insulinoma beta TC-1 cells. Endocrinology. 1992 May; 130(5):2890-6. PMID: 1374016.
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  177. Ron D, Habener JF. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992 Mar; 6(3):439-53. PMID: 1547942.
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  178. Nathan DM, Schreiber E, Fogel H, Mojsov S, Habener JF. Insulinotropic action of glucagonlike peptide-I-(7-37) in diabetic and nondiabetic subjects. Diabetes Care. 1992 Feb; 15(2):270-6. PMID: 1547685.
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  179. Holz GH, Kuhtreiber WM, Habener JF. Induction of glucose competence in pancreatic beta cells by glucagon-like peptide-1(7-37). Trans Assoc Am Physicians. 1992; 105:260-7. PMID: 1339238.
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  180. Ron D, Brasier AR, McGehee RE, Habener JF. Tumor necrosis factor-induced reversal of adipocytic phenotype of 3T3-L1 cells is preceded by a loss of nuclear CCAAT/enhancer binding protein (C/EBP). J Clin Invest. 1992 Jan; 89(1):223-33. PMID: 1729273; PMCID: PMC442840.
  181. Fehmann HC, Habener JF. Insulinotropic hormone glucagon-like peptide-I(7-37) stimulation of proinsulin gene expression and proinsulin biosynthesis in insulinoma beta TC-1 cells. Endocrinology. 1992 Jan; 130(1):159-66. PMID: 1309325.
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  182. Knepel W, Vallejo M, Chafitz JA, Habener JF. The pancreatic islet-specific glucagon G3 transcription factors recognize control elements in the rat somatostatin and insulin-I genes. Mol Endocrinol. 1991 Oct; 5(10):1457-66. PMID: 1685554.
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  183. Waeber G, Habener JF. Nuclear translocation and DNA recognition signals colocalized within the bZIP domain of cyclic adenosine 3',5'-monophosphate response element-binding protein CREB. Mol Endocrinol. 1991 Oct; 5(10):1431-8. PMID: 1837841.
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  184. Waeber G, Meyer TE, LeSieur M, Hermann HL, Gérard N, Habener JF. Developmental stage-specific expression of cyclic adenosine 3',5'-monophosphate response element-binding protein CREB during spermatogenesis involves alternative exon splicing. Mol Endocrinol. 1991 Oct; 5(10):1418-30. PMID: 1723142.
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  185. Fehmann HC, Habener JF. Homologous desensitization of the insulinotropic glucagon-like peptide-I (7-37) receptor on insulinoma (HIT-T15) cells. Endocrinology. 1991 Jun; 128(6):2880-8. PMID: 1645253.
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  186. Blackmore PF, Mojsov S, Exton JH, Habener JF. Absence of insulinotropic glucagon-like peptide-I(7-37) receptors on isolated rat liver hepatocytes. FEBS Lett. 1991 May 20; 283(1):7-10. PMID: 1645298.
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  187. Ron D, Brasier AR, Habener JF. Angiotensinogen gene-inducible enhancer-binding protein 1, a member of a new family of large nuclear proteins that recognize nuclear factor kappa B-binding sites through a zinc finger motif. Mol Cell Biol. 1991 May; 11(5):2887-95. PMID: 2017183; PMCID: PMC360079.
  188. Fehmann HC, Habener JF. Functional receptors for the insulinotropic hormone glucagon-like peptide-I(7-37) on a somatostatin secreting cell line. FEBS Lett. 1991 Feb 25; 279(2):335-40. PMID: 1672112.
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  189. Ron D, Brasier AR, Habener JF. Transcriptional regulation of hepatic angiotensinogen gene expression by the acute-phase response. Mol Cell Endocrinol. 1990 Dec 21; 74(3):C97-104. PMID: 2128877.
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  190. Knepel W, Chafitz J, Habener JF. Transcriptional activation of the rat glucagon gene by the cyclic AMP-responsive element in pancreatic islet cells. Mol Cell Biol. 1990 Dec; 10(12):6799-804. PMID: 2147227; PMCID: PMC362961.
  191. Brasier AR, Ron D, Tate JE, Habener JF. A family of constitutive C/EBP-like DNA binding proteins attenuate the IL-1 alpha induced, NF kappa B mediated trans-activation of the angiotensinogen gene acute-phase response element. EMBO J. 1990 Dec; 9(12):3933-44. PMID: 2174352; PMCID: PMC552164.
  192. Brasier AR, Ron D, Tate JE, Habener JF. Synergistic enhansons located within an acute phase responsive enhancer modulate glucocorticoid induction of angiotensinogen gene transcription. Mol Endocrinol. 1990 Dec; 4(12):1921-33. PMID: 1707127.
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  193. Lee CQ, Yun YD, Hoeffler JP, Habener JF. Cyclic-AMP-responsive transcriptional activation of CREB-327 involves interdependent phosphorylated subdomains. EMBO J. 1990 Dec; 9(13):4455-65. PMID: 2176153; PMCID: PMC552238.
  194. Habener JF, Meyer TE, Yun Y, Waeber G, Hoeffler JP. Characterization of a cAMP-regulated enhancer-binding protein. Metabolism. 1990 Sep; 39(9 Suppl 2):13-6. PMID: 2144888.
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  195. Habener JF. Cyclic AMP response element binding proteins: a cornucopia of transcription factors. Mol Endocrinol. 1990 Aug; 4(8):1087-94. PMID: 2149870.
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  196. Ron D, Brasier AR, Wright KA, Habener JF. The permissive role of glucocorticoids on interleukin-1 stimulation of angiotensinogen gene transcription is mediated by an interaction between inducible enhancers. Mol Cell Biol. 1990 Aug; 10(8):4389-95. PMID: 2370871; PMCID: PMC360996.
  197. Yun YD, Dumoulin M, Habener JF. DNA-binding and dimerization domains of adenosine 3',5'- cyclic monophosphate-responsive protein CREB reside in the carboxyl-terminal 66 amino acids. Mol Endocrinol. 1990 Jun; 4(6):931-9. PMID: 2146495.
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  198. Hoeffler JP, Meyer TE, Waeber G, Habener JF. Multiple adenosine 3',5'-cyclic [corrected] monophosphate response element DNA-binding proteins generated by gene diversification and alternative exon splicing. Mol Endocrinol. 1990 Jun; 4(6):920-30. PMID: 2146494.
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  199. Knepel W, Jepeal L, Habener JF. A pancreatic islet cell-specific enhancer-like element in the glucagon gene contains two domains binding distinct cellular proteins. J Biol Chem. 1990 May 25; 265(15):8725-35. PMID: 2160464.
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  200. Mojsov S, Kopczynski MG, Habener JF. Both amidated and nonamidated forms of glucagon-like peptide I are synthesized in the rat intestine and the pancreas. J Biol Chem. 1990 May 15; 265(14):8001-8. PMID: 1692320.
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  201. Gefel D, Hendrick GK, Mojsov S, Habener J, Weir GC. Glucagon-like peptide-I analogs: effects on insulin secretion and adenosine 3',5'-monophosphate formation. Endocrinology. 1990 Apr; 126(4):2164-8. PMID: 2156683.
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  202. Powers AC, Efrat S, Mojsov S, Spector D, Habener JF, Hanahan D. Proglucagon processing similar to normal islets in pancreatic alpha-like cell line derived from transgenic mouse tumor. Diabetes. 1990 Apr; 39(4):406-14. PMID: 2156740.
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  203. Ron D, Brasier AR, Wright KA, Tate JE, Habener JF. An inducible 50-kilodalton NF kappa B-like protein and a constitutive protein both bind the acute-phase response element of the angiotensinogen gene. Mol Cell Biol. 1990 Mar; 10(3):1023-32. PMID: 2106065; PMCID: PMC360957.
  204. Hoeffler JP, Habener JF. Characterization of a cyclic AMP regulatory element DNA-binding protein. Trends Endocrinol Metab. 1990 Jan-Feb; 1(3):155-8. PMID: 18411110.
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  205. Waeber G, Meyer TE, Hoeffler JP, Habener JF. Diversification of cyclic AMP-responsive enhancer binding proteins-generated by alternative exon splicing. Trans Assoc Am Physicians. 1990; 103:28-37. PMID: 1966745.
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  206. Grove JR, Deutsch PJ, Price DJ, Habener JF, Avruch J. Plasmids encoding PKI(1-31), a specific inhibitor of cAMP-stimulated gene expression, inhibit the basal transcriptional activity of some but not all cAMP-regulated DNA response elements in JEG-3 cells. J Biol Chem. 1989 Nov 25; 264(33):19506-13. PMID: 2479635.
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  207. Habener JF, Cwikel BJ, Hermann H, Hammer RE, Palmiter RD, Brinster RL. Metallothionein-vasopressin fusion gene expression in transgenic mice. Nephrogenic diabetes insipidus and brain transcripts localized to magnocellular neurons. J Biol Chem. 1989 Nov 05; 264(31):18844-52. PMID: 2808395.
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  208. Brasier AR, Tate JE, Habener JF. Optimized use of the firefly luciferase assay as a reporter gene in mammalian cell lines. Biotechniques. 1989 Nov-Dec; 7(10):1116-22. PMID: 2698191.
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  209. Jameson JL, Albanese C, Habener JF. Distinct adjacent protein-binding domains in the glycoprotein hormone alpha gene interact independently with a cAMP-responsive enhancer. J Biol Chem. 1989 Sep 25; 264(27):16190-6. PMID: 2476438.
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  210. Powers AC, Tedeschi F, Wright KE, Chan JS, Habener JF. Somatostatin gene expression in pancreatic islet cells is directed by cell-specific DNA control elements and DNA-binding proteins. J Biol Chem. 1989 Jun 15; 264(17):10048-56. PMID: 2566613.
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  211. Brasier AR, Tate JE, Ron D, Habener JF. Multiple cis-acting DNA regulatory elements mediate hepatic angiotensinogen gene expression. Mol Endocrinol. 1989 Jun; 3(6):1022-34. PMID: 2544800.
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  212. Hoeffler JP, Deutsch PJ, Lin J, Habener JF. Distinct adenosine 3',5'-monophosphate and phorbol ester-responsive signal transduction pathways converge at the level of transcriptional activation by the interactions of DNA-binding proteins. Mol Endocrinol. 1989 May; 3(5):868-80. PMID: 2547158.
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  213. Jameson JL, Powers AC, Gallagher GD, Habener JF. Enhancer and promoter element interactions dictate cyclic adenosine monophosphate mediated and cell-specific expression of the glycoprotein hormone alpha-gene. Mol Endocrinol. 1989 May; 3(5):763-72. PMID: 2474127.
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  214. Weir GC, Mojsov S, Hendrick GK, Habener JF. Glucagonlike peptide I (7-37) actions on endocrine pancreas. Diabetes. 1989 Mar; 38(3):338-42. PMID: 2645190.
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  215. Campbell DJ, Habener JF. Hybridization in situ studies of angiotensinogen gene expression in rat adrenal and lung. Endocrinology. 1989 Jan; 124(1):218-22. PMID: 2909366.
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  216. Habener JF, Vallejo M, Hoeffler JP. Factors that determine cell-specific gene expression in pancreatic endocrine tumor cells. Horm Res. 1989; 32(1-3):61-6. PMID: 2559019.
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  217. Hoeffler JP, Meyer TE, Yun Y, Jameson JL, Habener JF. Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. Science. 1988 Dec 09; 242(4884):1430-3. PMID: 2974179.
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  218. Deutsch PJ, Hoeffler JP, Jameson JL, Lin JC, Habener JF. Structural determinants for transcriptional activation by cAMP-responsive DNA elements. J Biol Chem. 1988 Dec 05; 263(34):18466-72. PMID: 2848037.
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  219. Philippe J, Powers AC, Mojsov S, Drucker DJ, Comi R, Habener JF. Expression of peptide hormone genes in human islet cell tumors. Diabetes. 1988 Dec; 37(12):1647-51. PMID: 2903836.
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  220. Deutsch PJ, Hoeffler JP, Jameson JL, Habener JF. Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins. Proc Natl Acad Sci U S A. 1988 Nov; 85(21):7922-6. PMID: 2847147; PMCID: PMC282325.
  221. Philippe J, Drucker DJ, Knepel W, Jepeal L, Misulovin Z, Habener JF. Alpha-cell-specific expression of the glucagon gene is conferred to the glucagon promoter element by the interactions of DNA-binding proteins. Mol Cell Biol. 1988 Nov; 8(11):4877-88. PMID: 3062372; PMCID: PMC365581.
  222. Powers AC, Philippe J, Hermann H, Habener JF. Sodium butyrate increases glucagon and insulin gene expression by recruiting immunocytochemically negative cells to produce hormone. Diabetes. 1988 Oct; 37(10):1405-10. PMID: 2843409.
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  223. Jameson JL, Becker CB, Lindell CM, Habener JF. Human follicle-stimulating hormone beta-subunit gene encodes multiple messenger ribonucleic acids. Mol Endocrinol. 1988 Sep; 2(9):806-15. PMID: 3139991.
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  224. Jameson JL, Jaffe RC, Deutsch PJ, Albanese C, Habener JF. The gonadotropin alpha-gene contains multiple protein binding domains that interact to modulate basal and cAMP-responsive transcription. J Biol Chem. 1988 Jul 15; 263(20):9879-86. PMID: 2454922.
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  225. Habener JF, Vo CD, Le DB, Gryan GP, Ercolani L, Wang AH. 5-Fluorodeoxyuridine as an alternative to the synthesis of mixed hybridization probes for the detection of specific gene sequences. Proc Natl Acad Sci U S A. 1988 Mar; 85(6):1735-9. PMID: 2964636; PMCID: PMC279853.
  226. Habener JF, Cwikel B, Hermann H, Hammer RE, Palmiter RD, Brinster RL. Expression of a metallothionein-vasopressin fusion gene in transgenic mice produces hypervasopressinemia and manifestations of nephrogenic diabetes insipidus. Trans Assoc Am Physicians. 1988; 101:155-62. PMID: 3269675.
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  227. Drucker DJ, Philippe J, Jepeal L, Habener JF. Glucagon gene 5'-flanking sequences promote islet cell-specific gene transcription. J Biol Chem. 1987 Nov 15; 262(32):15659-65. PMID: 3316202.
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  228. Campbell DJ, Habener JF. Cellular localization of angiotensinogen gene expression in brown adipose tissue and mesentery: quantification of messenger ribonucleic acid abundance using hybridization in situ. Endocrinology. 1987 Nov; 121(5):1616-26. PMID: 3665835.
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  229. Jameson JL, Klibanski A, Black PM, Zervas NT, Lindell CM, Hsu DW, Ridgway EC, Habener JF. Glycoprotein hormone genes are expressed in clinically nonfunctioning pituitary adenomas. J Clin Invest. 1987 Nov; 80(5):1472-8. PMID: 2824561; PMCID: PMC442406.
  230. Cwikel BJ, Habener JF. Provasopressin-neurophysin II processing is cell-specific in heterologous cell lines expressing a metallothionein-vasopressin fusion gene. J Biol Chem. 1987 Oct 15; 262(29):14235-40. PMID: 3654660.
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  231. Spindel ER, Sunday ME, Hofler H, Wolfe HJ, Habener JF, Chin WW. Transient elevation of messenger RNA encoding gastrin-releasing peptide, a putative pulmonary growth factor in human fetal lung. J Clin Invest. 1987 Oct; 80(4):1172-9. PMID: 3654977; PMCID: PMC442362.
  232. Lee HU, Campbell DJ, Habener JF. Developmental expression of the angiotensinogen gene in rat embryos. Endocrinology. 1987 Oct; 121(4):1335-42. PMID: 3653030.
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  233. Deutsch PJ, Jameson JL, Habener JF. Cyclic AMP responsiveness of human gonadotropin-alpha gene transcription is directed by a repeated 18-base pair enhancer. Alpha-promoter receptivity to the enhancer confers cell-preferential expression. J Biol Chem. 1987 Sep 05; 262(25):12169-74. PMID: 3040732.
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  234. Jameson JL, Deutsch PJ, Gallagher GD, Jaffe RC, Habener JF. trans-acting factors interact with a cyclic AMP response element to modulate expression of the human gonadotropin alpha gene. Mol Cell Biol. 1987 Sep; 7(9):3032-40. PMID: 2823116; PMCID: PMC367934.
  235. Drucker DJ, Philippe J, Mojsov S, Chick WL, Habener JF. Glucagon-like peptide I stimulates insulin gene expression and increases cyclic AMP levels in a rat islet cell line. Proc Natl Acad Sci U S A. 1987 May; 84(10):3434-8. PMID: 3033647; PMCID: PMC304885.
  236. Heinrich G, Habener JF. Genes encoding proteins with homologous contiguous repeat sequences are highly expressed in the serous cells of the rat submandibular gland. J Biol Chem. 1987 Apr 15; 262(11):5262-70. PMID: 3558393.
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  237. Klibanski A, Deutsch PJ, Jameson JL, Ridgway EC, Crowley WF, Hsu DW, Habener JF, Black PM. Luteinizing hormone-secreting pituitary tumor: biosynthetic characterization and clinical studies. J Clin Endocrinol Metab. 1987 Mar; 64(3):536-42. PMID: 3102541.
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  238. Philippe J, Drucker DJ, Habener JF. Glucagon gene transcription in an islet cell line is regulated via a protein kinase C-activated pathway. J Biol Chem. 1987 Feb 05; 262(4):1823-8. PMID: 2879843.
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  239. Jameson JL, Lindell CM, Habener JF. Gonadotropin and thyrotropin alpha- and beta-subunit gene expression in normal and neoplastic tissues characterized using specific messenger ribonucleic acid hybridization probes. J Clin Endocrinol Metab. 1987 Feb; 64(2):319-27. PMID: 3098775.
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  240. Mojsov S, Weir GC, Habener JF. Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas. J Clin Invest. 1987 Feb; 79(2):616-9. PMID: 3543057; PMCID: PMC424143.
  241. Philippe J, Chick WL, Habener JF. Multipotential phenotypic expression of genes encoding peptide hormones in rat insulinoma cell lines. J Clin Invest. 1987 Feb; 79(2):351-8. PMID: 2879852; PMCID: PMC424070.
  242. Philippe J, Drucker DJ, Chick WL, Habener JF. Transcriptional regulation of genes encoding insulin, glucagon, and angiotensinogen by sodium butyrate in a rat islet cell line. Mol Cell Biol. 1987 Jan; 7(1):560-3. PMID: 3550424; PMCID: PMC365105.
  243. Drucker DJ, Philippe J, Jepeal L, Habener JF. cis-acting DNA sequence controls glucagon gene expression in pancreatic islet cells. Trans Assoc Am Physicians. 1987; 100:109-15. PMID: 3331856.
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  244. Brasier AR, Philippe J, Campbell DJ, Habener JF. Novel expression of the angiotensinogen gene in a rat pancreatic islet cell line. Transcriptional regulation by glucocorticoids. J Biol Chem. 1986 Dec 05; 261(34):16148-54. PMID: 3536923.
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  245. Philippe J, Mojsov S, Drucker DJ, Habener JF. Proglucagon processing in a rat islet cell line resembles phenotype of intestine rather than pancreas. Endocrinology. 1986 Dec; 119(6):2833-9. PMID: 3536450.
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  246. Jameson JL, Jaffe RC, Gleason SL, Habener JF. Transcriptional regulation of chorionic gonadotropin alpha- and beta-subunit gene expression by 8-bromo-adenosine 3',5'-monophosphate. Endocrinology. 1986 Dec; 119(6):2560-7. PMID: 3465528.
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  247. Mojsov S, Heinrich G, Wilson IB, Ravazzola M, Orci L, Habener JF. Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing. J Biol Chem. 1986 Sep 05; 261(25):11880-9. PMID: 3528148.
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  248. Drucker DJ, Mojsov S, Habener JF. Cell-specific post-translational processing of preproglucagon expressed from a metallothionein-glucagon fusion gene. J Biol Chem. 1986 Jul 25; 261(21):9637-43. PMID: 3525530.
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  249. Campbell DJ, Habener JF. Angiotensinogen gene is expressed and differentially regulated in multiple tissues of the rat. J Clin Invest. 1986 Jul; 78(1):31-9. PMID: 3013940; PMCID: PMC329527.
  250. Ellison MJ, Feigon J, Kelleher RJ, Wang AH, Habener JF, Rich A. An assessment of the Z-DNA forming potential of alternating dA-dT stretches in supercoiled plasmids. Biochemistry. 1986 Jun 17; 25(12):3648-55. PMID: 3718951.
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  251. Jameson JL, Lindell CM, Hsu DW, Habener JF, Ridgway EC. Expression of chorionic gonadotropin-beta-like messenger ribonucleic acid in an alpha-subunit-secreting pituitary adenoma. J Clin Endocrinol Metab. 1986 Jun; 62(6):1271-8. PMID: 2422195.
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  252. Jameson JL, Lindell CM, Habener JF. Evolution of different transcriptional start sites in the human luteinizing hormone and chorionic gonadotropin beta-subunit genes. DNA. 1986 Jun; 5(3):227-34. PMID: 2424697.
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  253. Low MJ, Lechan RM, Hammer RE, Brinster RL, Habener JF, Mandel G, Goodman RH. Gonadotroph-specific expression of metallothionein fusion genes in pituitaries of transgenic mice. Science. 1986 Feb 28; 231(4741):1002-4. PMID: 2868526.
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  254. Spindel ER, Zilberberg MD, Habener JF, Chin WW. Two prohormones for gastrin-releasing peptide are encoded by two mRNAs differing by 19 nucleotides. Proc Natl Acad Sci U S A. 1986 Jan; 83(1):19-23. PMID: 3001723; PMCID: PMC322782.
  255. Brasier AR, Philippe J, Campbell DJ, Habener JF. Glucocorticoid and thyroid hormone regulation of angiotensinogen gene expression in a pancreatic islet cell line. Trans Assoc Am Physicians. 1986; 99:13-9. PMID: 3299983.
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  256. Ellison MJ, Kelleher RJ, Wang AH, Habener JF, Rich A. Sequence-dependent energetics of the B-Z transition in supercoiled DNA containing nonalternating purine-pyrimidine sequences. Proc Natl Acad Sci U S A. 1985 Dec; 82(24):8320-4. PMID: 3866225; PMCID: PMC390907.
  257. Habener JF. Regulation of polypeptide-hormone biosynthesis at the level of the genome. Am J Physiol. 1985 Sep; 249(3 Pt 1):C191-9. PMID: 3898860.
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  258. Uhl GR, Zingg HH, Habener JF. Vasopressin mRNA in situ hybridization: localization and regulation studied with oligonucleotide cDNA probes in normal and Brattleboro rat hypothalamus. Proc Natl Acad Sci U S A. 1985 Aug; 82(16):5555-9. PMID: 3860875; PMCID: PMC391161.
  259. Low MJ, Hammer RE, Goodman RH, Habener JF, Palmiter RD, Brinster RL. Tissue-specific posttranslational processing of pre-prosomatostatin encoded by a metallothionein-somatostatin fusion gene in transgenic mice. Cell. 1985 May; 41(1):211-9. PMID: 2859927.
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  260. Shupnik MA, Chin WW, Habener JF, Ridgway EC. Transcriptional regulation of the thyrotropin subunit genes by thyroid hormone. J Biol Chem. 1985 Mar 10; 260(5):2900-3. PMID: 3972809.
    View in: PubMed
  261. Chin WW, Shupnik MA, Ross DS, Habener JF, Ridgway EC. Regulation of the alpha and thyrotropin beta-subunit messenger ribonucleic acids by thyroid hormones. Endocrinology. 1985 Mar; 116(3):873-8. PMID: 2578951.
    View in: PubMed
  262. Jameson JL, Lindell CM, Habener JF, Ridgway EC. Transcription of an unusual luteinizing hormone beta-subunit-like messenger ribonucleic acid in an alpha-subunit-secreting pituitary adenoma. Trans Assoc Am Physicians. 1985; 98:198-203. PMID: 2430356.
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  263. Zingg HH, Habener JF, Patel YC. Approaches to the study of somatostatin biosynthesis. Adv Exp Med Biol. 1985; 188:49-58. PMID: 2863949.
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  264. Goodman RH, Montminy MR, Low MJ, Habener JF. Biosynthesis of rat preprosomatostatin. Adv Exp Med Biol. 1985; 188:31-47. PMID: 2863939.
    View in: PubMed
  265. Jameson L, Chin WW, Hollenberg AN, Chang AS, Habener JF. The gene encoding the beta-subunit of rat luteinizing hormone. Analysis of gene structure and evolution of nucleotide sequence. J Biol Chem. 1984 Dec 25; 259(24):15474-80. PMID: 6096374.
    View in: PubMed
  266. Heinrich G, Gros P, Lund PK, Bentley RC, Habener JF. Pre-proglucagon messenger ribonucleic acid: nucleotide and encoded amino acid sequences of the rat pancreatic complementary deoxyribonucleic acid. Endocrinology. 1984 Dec; 115(6):2176-81. PMID: 6548696.
    View in: PubMed
  267. Heinrich G, Gros P, Habener JF. Glucagon gene sequence. Four of six exons encode separate functional domains of rat pre-proglucagon. J Biol Chem. 1984 Nov 25; 259(22):14082-7. PMID: 6094539.
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  268. Spindel ER, Chin WW, Price J, Rees LH, Besser GM, Habener JF. Cloning and characterization of cDNAs encoding human gastrin-releasing peptide. Proc Natl Acad Sci U S A. 1984 Sep; 81(18):5699-703. PMID: 6207529; PMCID: PMC391778.
  269. Majzoub JA, Pappey A, Burg R, Habener JF. Vasopressin gene is expressed at low levels in the hypothalamus of the Brattleboro rat. Proc Natl Acad Sci U S A. 1984 Sep; 81(17):5296-9. PMID: 6591192; PMCID: PMC391690.
  270. Habener JF, Rosenblatt M, Potts JT. Parathyroid hormone: biochemical aspects of biosynthesis, secretion, action, and metabolism. Physiol Rev. 1984 Jul; 64(3):985-1053. PMID: 6330779.
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  271. Zingg HH, Goodman RH, Habener JF. Developmental expression of the rat somatostatin gene. Endocrinology. 1984 Jul; 115(1):90-4. PMID: 6145584.
    View in: PubMed
  272. Montminy MR, Goodman RH, Horovitch SJ, Habener JF. Primary structure of the gene encoding rat preprosomatostatin. Proc Natl Acad Sci U S A. 1984 Jun; 81(11):3337-40. PMID: 6145156; PMCID: PMC345502.
  273. Heinrich G, Kronenberg HM, Potts JT, Habener JF. Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and deduced amino acid sequence of rat preproparathyroid hormone. J Biol Chem. 1984 Mar 10; 259(5):3320-9. PMID: 6321505.
    View in: PubMed
  274. Low MJ, Goodman RH, Brinster RL, Palmiter RD, Hammer RE, Habener JF. High plasma levels of immunoreactive somatostatin in transgenic mice expressing a metallothionein-somatostatin fusion gene. Trans Assoc Am Physicians. 1984; 97:205-9. PMID: 6152571.
    View in: PubMed
  275. Shupnik MA, Chin WW, Ross DS, Downing MF, Habener JF, Ridgway EC. Regulation by thyroxine of the mRNA encoding the alpha subunit of mouse thyrotropin. J Biol Chem. 1983 Dec 25; 258(24):15120-4. PMID: 6197411.
    View in: PubMed
  276. Majzoub JA, Rich A, van Boom J, Habener JF. Vasopressin and oxytocin mRNA regulation in the rat assessed by hybridization with synthetic oligonucleotides. J Biol Chem. 1983 Dec 10; 258(23):14061-4. PMID: 6689019.
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  277. Chin WW, Godine JE, Klein DR, Chang AS, Tan LK, Habener JF. Nucleotide sequence of the cDNA encoding the precursor of the beta subunit of rat lutropin. Proc Natl Acad Sci U S A. 1983 Aug; 80(15):4649-53. PMID: 6192440; PMCID: PMC384101.
  278. Lechan RM, Goodman RH, Rosenblatt M, Reichlin S, Habener JF. Prosomatostatin-specific antigen in rat brain: localization by immunocytochemical staining with an antiserum to a synthetic sequence of preprosomatostatin. Proc Natl Acad Sci U S A. 1983 May; 80(9):2780-4. PMID: 6133283; PMCID: PMC393912.
  279. Lund PK, Goodman RH, Montminy MR, Dee PC, Habener JF. Anglerfish islet pre-proglucagon II. Nucleotide and corresponding amino acid sequence of the cDNA. J Biol Chem. 1983 Mar 10; 258(5):3280-4. PMID: 6338015.
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  280. Heinrich G, Kronenberg HM, Potts JT, Habener JF. Parathyroid hormone messenger ribonucleic acid: effects of calcium on cellular regulation in vitro. Endocrinology. 1983 Feb; 112(2):449-58. PMID: 6687356.
    View in: PubMed
  281. Chin WW, Maizel JV, Habener JF. Difference in sizes of human compared to murine alpha-subunits of the glycoprotein hormones arises by four-codon gene deletion or insertion. Endocrinology. 1983 Feb; 112(2):482-5. PMID: 6184214.
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  282. Jacobs JW, Goltzman D, Habener JF. Absence of detectable calcitonin synthesis in the pituitary using cloned complementary deoxyribonucleic acid probes. Endocrinology. 1982 Dec; 111(6):2014-9. PMID: 6128219.
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  283. Godine JE, Chin WW, Habener JF. alpha Subunit of rat pituitary glycoprotein hormones. Primary structure of the precursor determined from the nucleotide sequence of cloned cDNAs. J Biol Chem. 1982 Jul 25; 257(14):8368-71. PMID: 6177696.
    View in: PubMed
  284. Majzoub JA, Dee PC, Habener JF. Cellular and cell-free processing of parathyroid secretory proteins. J Biol Chem. 1982 Apr 10; 257(7):3581-8. PMID: 7061498.
    View in: PubMed
  285. Goodman RH, Jacobs JW, Dee PC, Habener JF. Somatostatin-28 encoded in a cloned cDNA obtained from a rat medullary thyroid carcinoma. J Biol Chem. 1982 Feb 10; 257(3):1156-9. PMID: 6120163.
    View in: PubMed
  286. Godine JE, Chin WW, Habener JF. Detection of two precursors to each of the subunits of human chorionic gonadotropin translated from placental mRNA in the wheat germ cell-free system. Biochem Biophys Res Commun. 1982 Jan 29; 104(2):463-73. PMID: 7073694.
    View in: PubMed
  287. Lund PK, Goodman RH, Dee PC, Habener JF. Pancreatic preproglucagon cDNA contains two glucagon-related coding sequences arranged in tandem. Proc Natl Acad Sci U S A. 1982 Jan; 79(2):345-9. PMID: 7043459; PMCID: PMC345726.
  288. Habener JF. Recent advances in parathyroid hormone research. Clin Biochem. 1981 Oct; 14(5):223-9. PMID: 7037226.
    View in: PubMed
  289. Chin WW, Kronenberg HM, Dee PC, Maloof F, Habener JF. Nucleotide sequence of the mRNA encoding the pre-alpha-subunit of mouse thyrotropin. Proc Natl Acad Sci U S A. 1981 Sep; 78(9):5329-33. PMID: 6272299; PMCID: PMC348738.
  290. Jacobs JW, Goodman RH, Chin WW, Dee PC, Habener JF, Bell NH, Potts JT. Calcitonin messenger RNA encodes multiple polypeptides in a single precursor. Science. 1981 Jul 24; 213(4506):457-9. PMID: 6264603.
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  291. Lund PK, Goodman RH, Habener JF. Pancreatic pre-proglucagons are encoded by two separate mRNAs. J Biol Chem. 1981 Jul 10; 256(13):6515-8. PMID: 6165720.
    View in: PubMed
  292. Lund PK, Goodman RH, Habener JF. Intestinal glucagon mRNA identified by hybridization to a cloned islet cDNA encoding a precursor. Biochem Biophys Res Commun. 1981 Jun; 100(4):1659-66. PMID: 7028035.
    View in: PubMed
  293. Chin WW, Habener JF. Thyroid-stimulating hormone subunits: evidence from endoglycosidase-H cleavage for late presecretory glycosylation. Endocrinology. 1981 May; 108(5):1628-33. PMID: 7215288.
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  294. Jacobs JW, Lund PK, Potts JT, Bell NH, Habener JF. Procalcitonin is a glycoprotein. J Biol Chem. 1981 Mar 25; 256(6):2803-7. PMID: 7204375.
    View in: PubMed
  295. Chin WW, Maloof F, Habener JF. Thyroid-stimulating hormone biosynthesis. Cellular processing, assembly, and release of subunits. J Biol Chem. 1981 Mar 25; 256(6):3059-66. PMID: 7204390.
    View in: PubMed
  296. Godine JE, Chin WW, Habener JF. Cell-free synthesis and processing of the precursors to the subunits of luteinizing hormone. J Biol Chem. 1981 Mar 10; 256(5):2475-9. PMID: 7462250.
    View in: PubMed
  297. Chin WW, Goodman RH, Jacobs JW, Wolfe HJ, Daniels GH, Habener JF. Medullary thyroid carcinoma identified by cell-free translation of tumor messenger ribonucleic acid in a patient with a neck mass and the syndrome of ectopic adrenocorticotropin. J Clin Endocrinol Metab. 1981 Mar; 52(3):572-5. PMID: 6257751.
    View in: PubMed
  298. Goodman RH, Lund PK, Barnett FH, Habener JF. Intestinal pre-prosomatostatin. Identification of mRNA coding for a precursor by cell-free translations and hybridization with a cloned islet cDNA. J Biol Chem. 1981 Feb 25; 256(4):1499-501. PMID: 6109721.
    View in: PubMed
  299. Habener JF, Kronenberg HM, Potts JT. biosynthesis of pre-proparathyroid hormone. Methods Cell Biol. 1981; 23:51-71. PMID: 7035810.
    View in: PubMed
  300. Habener JF. Principles of peptide-hormones biosynthesis. Adv Biochem Psychopharmacol. 1981; 28:21-34. PMID: 7010936.
    View in: PubMed
  301. Majzoub JA, Rosenblatt M, Fennick B, Maunus R, Kronenberg HM, Potts JT, Habener JF. Synthetic pre-proparathyroid hormone leader sequence inhibits cell-free processing of placental, parathyroid, and pituitary prehormones. J Biol Chem. 1980 Dec 10; 255(23):11478-83. PMID: 7440551.
    View in: PubMed
  302. Chin WW, Habener JF, Martorana MA, Keutmann HT, Kieffer JD, Maloof F. Thyroid-stimulating hormone: isolation and partial characterization of hormone and subunits from a mouse thyrotrope tumor. Endocrinology. 1980 Nov; 107(5):1384-92. PMID: 7000492.
    View in: PubMed
  303. Goodman RH, Jacobs JW, Chin WW, Lund PK, Dee PC, Habener JF. Nucleotide sequence of a cloned structural gene coding for a precursor of pancreatic somatostatin. Proc Natl Acad Sci U S A. 1980 Oct; 77(10):5869-73. PMID: 6108560; PMCID: PMC350173.
  304. Godine JE, Chin WW, Habener JF. Luteinizing and follicle-stimulating hormones. Cell-free translations of messenger RNAs coding for subunit precursors. J Biol Chem. 1980 Sep 25; 255(18):8780-3. PMID: 6773948.
    View in: PubMed
  305. Goodman RH, Lund PK, Jacobs JW, Habener JF. Pre-prosomatostatins. Products of cell-free translations of messenger RNAs from anglerfish islets. J Biol Chem. 1980 Jul 25; 255(14):6549-52. PMID: 6104664.
    View in: PubMed
  306. Lund PK, Goodman RH, Jacobs JW, Habener JF. Glucagon precursors identified by immunoprecipitation of products of cell-free translation of messenger RNA. Diabetes. 1980 Jul; 29(7):583-6. PMID: 6991342.
    View in: PubMed
  307. Habener JF, Maunus R, Dee PC, Potts JT. Early events in the cellular formation of proparathyroid hormone. J Cell Biol. 1980 May; 85(2):292-8. PMID: 7372710; PMCID: PMC2110632.
  308. Potts JT, Kronenberg HM, Habener JF, Rich A. Biosynthesis of parathyroid hormone. Ann N Y Acad Sci. 1980; 343:38-55. PMID: 6994557.
    View in: PubMed
  309. Goodman RH, Jacobs JW, Habener JF. Cell-free translation of messenger RNA coding for a precursor of human calcitonin. Biochem Biophys Res Commun. 1979 Dec 14; 91(3):932-8. PMID: 526292.
    View in: PubMed
  310. Habener JF, Rosenblatt M, Dee PC, Potts JT. Cellular processing of pre-proparathyroid hormone involves rapid hydrolysis of the leader sequence. J Biol Chem. 1979 Nov 10; 254(21):10596-9. PMID: 500597.
    View in: PubMed
  311. Jacobs JW, Potts JT, Bell NH, Habener JF. Calcitonin precursor identified by cell-free translation of mRNA. J Biol Chem. 1979 Nov 10; 254(21):10600-3. PMID: 500598.
    View in: PubMed
  312. Habener JF, Segre GV. Parathyroid hormone radioimmunoassay. Ann Intern Med. 1979 Nov; 91(5):782-5. PMID: 496119.
    View in: PubMed
  313. Majzoub JA, Kronenberg HM, Potts JT, Rich A, Habener JF. Identification and cell-free translation of mRNA coding for a precursor of parathyroid secretory protein. J Biol Chem. 1979 Aug 10; 254(15):7449-55. PMID: 457691.
    View in: PubMed
  314. Habener JF, Potts JT. Cleavage-associated enhancement of an antigenic site in the biologically active NH2-terminal region of parathyroid hormone. Endocrinology. 1979 Jul; 105(1):115-9. PMID: 87321.
    View in: PubMed
  315. Mayer GP, Keaton JA, Hurst JG, Habener JF. Effects of plasma calcium concentration on the relative proportion of hormone and carboxyl fragments in parathyroid venous blood. Endocrinology. 1979 Jun; 104(6):1778-84. PMID: 446397.
    View in: PubMed
  316. Futrell JM, Roth SI, Su SP, Habener JF, Segre GV, Potts JT. Immunocytochemical localization of parathyroid hormone in bovine parathyroid glands and human parathyroid adenomas. Am J Pathol. 1979 Mar; 94(3):615-22. PMID: 371413; PMCID: PMC2042270.
  317. Rosenblatt M, Habener JF, Tyler GA, Shepard GL, Potts JT. Chemical synthesis of the precursor-specific region of pre-proparathyroid hormone. J Biol Chem. 1979 Feb 25; 254(4):1414-21. PMID: 762137.
    View in: PubMed
  318. Habener JF, Potts JT. Subcellular distributions of parathyroid hormone, hormonal precursors, and parathyroid secretory protein. Endocrinology. 1979 Jan; 104(1):265-75. PMID: 446353.
    View in: PubMed
  319. Chin WW, Habener JF, Kieffer JD, Maloof F. Cell-free translation of the messenger RNA coding for the alpha subunit of thyroid-stimulating hormone. J Biol Chem. 1978 Nov 25; 253(22):7985-8. PMID: 711729.
    View in: PubMed
  320. Habener JF, Kronenberg HM. Parathyroid hormone biosynthesis: structure and function of biosynthetic precursors. Fed Proc. 1978 Oct; 37(12):2561-6. PMID: 700166.
    View in: PubMed
  321. Habener JF, Potts JT. Biosynthesis of parathyroid hormone (second of two parts). N Engl J Med. 1978 Sep 21; 299(12):635-44. PMID: 355880.
    View in: PubMed
  322. Habener JF, Potts JT. Biosynthesis of parathyroid hormone (first of two parts). N Engl J Med. 1978 Sep 14; 299(11):580-5. PMID: 355878.
    View in: PubMed
  323. Ravazzola M, Orci L, Habener JF, Potts JT. Parathyroid secretory protein: Immunocytochemical localisation within cells that contain parathyroid hormone. Lancet. 1978 Aug 12; 2(8085):371-2. PMID: 79733.
    View in: PubMed
  324. Habener JF. Responsiveness of neoplastic and hyperplastic parathyroid tissues to calcium in vitro. J Clin Invest. 1978 Aug; 62(2):436-50. PMID: 670402; PMCID: PMC371782.
  325. Habener JF, Rosenblatt M, Kemper B, Kronenberg HM, Rich A, Potts JT. Pre-proparathyroid hormone; amino acid sequence, chemical synthesis, and some biological studies of the precursor region. Proc Natl Acad Sci U S A. 1978 Jun; 75(6):2616-20. PMID: 96437; PMCID: PMC392613.
  326. Habener JF, Stevens TD, Ravazzola M, Orci L, Potts JT. Effects of calcium ionophores on the synthesis and release of parathyroid hormone. Endocrinology. 1977 Nov; 101(5):1524-37. PMID: 334518.
    View in: PubMed
  327. Habener JF, Chang HT, Potts JT. Enzymic processing of proparathyroid hormone by cell-free extracts of parathyroid glands. Biochemistry. 1977 Aug 23; 16(17):3910-7. PMID: 409427.
    View in: PubMed
  328. Kronenberg HM, Roberts BE, Habener JF, Potts JT, Rich A. DNA complementary to parathyroid mRNA directs synthesis of pre-proparathyroid hormone in a linked transcription-translation system. Nature. 1977 Jun 30; 267(5614):804-7. PMID: 70756.
    View in: PubMed
  329. Cutler GB, Habener JF, Potts JT. Biosynthesis and secretion of calcitonin by avian ultimobranchial glands. Endocrinology. 1977 Feb; 100(2):537-48. PMID: 832637.
    View in: PubMed
  330. Habener JF, Amherdt M, Orci L. Subcellular organelles involved in the conversion of biosynthetic precursors of parathyroid hormone. Trans Assoc Am Physicians. 1977; 90:366-79. PMID: 611667.
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  331. Habener JF, Potts JT, Rich A. Pre-proparathyroid hormone. Evidence for an early biosynthetic precursor of proparathyroid hormone. J Biol Chem. 1976 Jul 10; 251(13):3893-9. PMID: 932012.
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  332. Habener JF, Mayer GP, Dee PC, Potts JT. Metabolism of amino- and carboxyl-sequence immunoreactive parathyroid hormone in the bovine: evidence for peripheral cleavage of hormone. Metabolism. 1976 Apr; 25(4):385-95. PMID: 1263832.
    View in: PubMed
  333. Mayer GP, Habener JF, Potts JT. Parathyroid hormone secretion in vivo. Demonstration of a calcium-independent nonsuppressible component of secretion. J Clin Invest. 1976 Mar; 57(3):678-83. PMID: 1249204; PMCID: PMC436701.
  334. Habener JF, Stevens TD, Tregear GW, Potts JT. RAdioimmunoassay of human proparathyroid hormone: analysis of hormone content in tissue extracts and in plasma. J Clin Endocrinol Metab. 1976 Mar; 42(3):520-30. PMID: 1254693.
    View in: PubMed
  335. Kemper B, Habener JF, Potts JT, Rich A. Pre-proparathyroid hormone: fidelity of the translation of parathyroid messenger RNA by extracts of wheat germ. Biochemistry. 1976 Jan 13; 15(1):20-5. PMID: 1247507.
    View in: PubMed
  336. Kemper B, Habener JF, Ernst MD, Potts JT, Rich A. Pre-proparathyroid hormone: analysis of radioactive tryptic peptides and amino acid sequence. Biochemistry. 1976 Jan 13; 15(1):15-9. PMID: 1247503.
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  337. Habener JF, Kemper BW, Rich A, Potts JT. Biosynthesis of parathyroid hormone. Recent Prog Horm Res. 1976; 33:249-308. PMID: 801192.
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  338. Habener JF, Potts JT. Relative effectiveness of magnesium and calcium on the secretion and biosynthesis of parathyroid hormone in vitro. Endocrinology. 1976 Jan; 98(1):197-202. PMID: 1248443.
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  339. Habener JF. New concepts in the formation, regulation of release, and metabolism of parathyroid hormone. Ciba Found Symp. 1976; 41:197-224. PMID: 780074.
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  340. Habener JF, Kemper B, Potts JT, Rich A. Parathyroid mRNA directs the synthesis of pre-proparathyroid hormone and proparathyroid hormone in the Krebs ascites cell-free system. Biochem Biophys Res Commun. 1975 Dec 01; 67(3):1114-21. PMID: 1201063.
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  341. Habener JF, Kemper B, Potts JT, Rich A. Pre - proparathyroid hormone identified by cell - free translation of messenger RNA from hyperplastic human parathyroid tissue. J Clin Invest. 1975 Nov; 56(5):1328-33. PMID: 52656; PMCID: PMC301997.
  342. Habener JF, Kemper B, Potts JT. Calcium-dependent intracellular degradation of parathyroid hormone: a possible mechanism for the regulation of hormone stores. Endocrinology. 1975 Aug; 97(2):431-41. PMID: 1157761.
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  343. Kemper B, Habener JF, Rich A, Potts JT. Microtubules and the intracellular conversion of proparathyroid hormone to parathyroid hormone. Endocrinology. 1975 Apr; 96(4):903-12. PMID: 1120480.
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  344. Singer FR, Segre GV, Habener JF, Potts JT. Peripheral metabolism of bovine parathyroid hormone in the dog. Metabolism. 1975 Feb; 24(2):139-44. PMID: 1113678.
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  345. Habener JF, Potts JT. Technique for the identification of a biosynthetic precursor to parathyroid hormone. Methods Enzymol. 1975; 37:345-60. PMID: 1128250.
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  346. Singer FR, Habener JF. Multiple immunoreactive forms of calcitonin in human plasma. Biochem Biophys Res Commun. 1974 Nov 27; 61(2):710-6. PMID: 4477010.
    View in: PubMed
  347. Cutler GB, Habener JF, Potts JT. Comparative immunochemical studies of chicken ultimobranchial calcitonin. Gen Comp Endocrinol. 1974 Oct; 24(2):183-90. PMID: 4140802.
    View in: PubMed
  348. Kemper B, Habener JF, Mulligan RC, Potts JT, Rich A. Pre-proparathyroid hormone: a direct translation product of parathyroid messenger RNA. Proc Natl Acad Sci U S A. 1974 Sep; 71(9):3731-5. PMID: 4530333; PMCID: PMC433850.
  349. Segre GV, Niall HD, Habener JF, Potts JT. Metabolism of parathyroid hormone: physiologic and clinical significance. Am J Med. 1974 Jun; 56(6):774-84. PMID: 4133938.
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  350. Jacobs JW, Kemper B, Niall HD, Habener JF, Potts JT. Structural analysis of human proparathyroid hormone by a new microsequencing approach. Nature. 1974 May 10; 249(453):155-7. PMID: 4833516.
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  351. Kemper B, Habener JF, Rich A, Potts JT. Parathyroid secretion: discovery of a major calcium-dependent protein. Science. 1974 Apr 12; 184(4133):167-9. PMID: 4815723.
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  352. Habener JF, Tregear GW, Stevens ED, Dee PC, Potts JT. Radioimmunoassay for proparathyroid hormone. Endocr Res Commun. 1974; 1(1):1-17. PMID: 4461260.
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  353. Habener JF, Mayer GP, Powell D, Murray TM, Singer FR, Potts JT. Dextran-charcoal and dioxane phase separation methods in the radioimmunoassays for parathyroid hormone and calcitonin. Clin Chim Acta. 1973 May 18; 45(3):225-33. PMID: 4736058.
    View in: PubMed
  354. Potts JT, Niall HD, Tregear GW, van Rietschoten J, Habener JF, Segre GV, Keutmann HT. Chemical and biologic studies of proparathyroid hormone and parathyroid hormone: analysis of hormone biosynthesis and metabolism. Mt Sinai J Med. 1973 May-Jun; 40(3):448-61. PMID: 4541313.
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  355. Habener JF, Kemper B, Potts JT, Rich A. Bovine proparathyroid hormone: structural analysis of radioactive peptides formed by limited cleavage. Endocrinology. 1973 Jan; 92(1):219-26. PMID: 4681926.
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  356. Segre GV, Habener JF, Powell D, Tregear GW, Potts JT. Parathyroid Hormone in Human Plasma: IMMUNOCHEMICAL CHARACTERIZATION AND BIOLOGICAL IMPLICATIONS. J Clin Invest. 1972 Dec; 51(12):3163-72. PMID: 16695961.
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  357. Habener JF, Kemper B, Potts JT, Rich A. Proparathyroid hormone: biosynthesis by human parathyroid adenomas. Science. 1972 Nov 10; 178(4061):630-3. PMID: 5086399.
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  358. Habener JF, Segre GV, Powell D, Murray TM, Potts JT. Immunoreactive parathyroid hormone in circulation of man. Nat New Biol. 1972 Aug 02; 238(83):152-4. PMID: 4506194.
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  359. Singer FR, Habener JF, Greene E, Godin P, Potts JT. Inactivation of calcitonin by specific organs. Nat New Biol. 1972 Jun 28; 237(78):269-70. PMID: 4504460.
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  360. Habener JF, Singer FR, Deftos LJ, Potts JT. Immunological stability of calcitonin in plasma. Endocrinology. 1972 Apr; 90(4):952-60. PMID: 4622097.
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  361. Deftos LJ, Habener JF, Mayer GP, Bury AE, Potts JT. Radioimmunoassay for bovine calcitonin. J Lab Clin Med. 1972 Mar; 79(3):480-90. PMID: 5061399.
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  362. Kemper B, Habener JF, Potts JT, Rich A. Proparathyroid hormone: identification of a biosynthetic precursor to parathyroid hormone. Proc Natl Acad Sci U S A. 1972 Mar; 69(3):643-7. PMID: 4501579; PMCID: PMC426526.
  363. Habener JF, Powell D, Murray TM, Mayer GP, Potts JT. Parathyroid hormone: secretion and metabolism in vivo. Proc Natl Acad Sci U S A. 1971 Dec; 68(12):2986-91. PMID: 5289243; PMCID: PMC389575.
  364. Deftos LJ, Bury AE, Habener JF, Singer FR, Potts JT. Immunoassay for human calcitonin. II. Clinical studies. Metabolism. 1971 Dec; 20(12):1129-37. PMID: 5001933.
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  365. Habener JF, Singer FR, Deftos LJ, Neer RM, Potts JT. Explanation for unusual potency of salmon calcitonin. Nat New Biol. 1971 Jul 21; 232(29):91-2. PMID: 5285350.
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  366. Habener JF, Bynum BS, Shack J. Changes in the sedimentation properties of HeLa cell DNA and nucleoprotein during replication. Biochim Biophys Acta. 1969 Dec 16; 195(2):484-93. PMID: 4983707.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.