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Angeles Fernandez-Gonzalez, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Taglauer ES, Fernandez-Gonzalez A, Willis GR, Reis M, Yeung V, Liu X, Prince LS, Mitsialis SA, Kourembanas S. Antenatal Mesenchymal Stromal Cell Extracellular Vesicle Therapy Prevents Preeclamptic Lung Injury in Mice. Am J Respir Cell Mol Biol. 2022 01; 66(1):86-95. PMID: 34614384; PMCID: PMC8803363.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  2. Willis GR, Reis M, Gheinani AH, Fernandez-Gonzalez A, Taglauer ES, Yeung V, Liu X, Ericsson M, Haas E, Mitsialis SA, Kourembanas S. Extracellular Vesicles Protect the Neonatal Lung from Hyperoxic Injury through the Epigenetic and Transcriptomic Reprogramming of Myeloid Cells. Am J Respir Crit Care Med. 2021 12 15; 204(12):1418-1432. PMID: 34699335; PMCID: PMC8865710.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  3. Reis M, Willis GR, Fernandez-Gonzalez A, Yeung V, Taglauer E, Magaletta M, Parsons T, Derr A, Liu X, Maehr R, Kourembanas S, Mitsialis SA. Mesenchymal Stromal Cell-Derived Extracellular Vesicles Restore Thymic Architecture and T Cell Function Disrupted by Neonatal Hyperoxia. Front Immunol. 2021; 12:640595. PMID: 33936055; PMCID: PMC8082426.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  4. Fernandez-Gonzalez A, Willis GR, Yeung V, Reis M, Liu X, Mitsialis SA, Kourembanas S. Therapeutic Effects of Mesenchymal Stromal Cell-Derived Small Extracellular Vesicles in Oxygen-Induced Multi-Organ Disease: A Developmental Perspective. Front Cell Dev Biol. 2021; 9:647025. PMID: 33796534; PMCID: PMC8007882.
    Citations: 5     
  5. Fernandez-Gonzalez A. TGF-ß and NF-?B Cross-Talk: Unexpected Encounters in the Developing Lung. Am J Respir Cell Mol Biol. 2021 03; 64(3):275-276. PMID: 33321052.
    Citations:    Fields:    
  6. Taglauer ES, Fernandez-Gonzalez A, Willis GR, Reis M, Yeung V, Liu X, Mitsialis SA, Kourembanas S. Mesenchymal stromal cell-derived extracellular vesicle therapy prevents preeclamptic physiology through intrauterine immunomodulation†. Biol Reprod. 2021 02 11; 104(2):457-467. PMID: 33112369.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  7. Willis GR, Fernandez-Gonzalez A, Reis M, Yeung V, Liu X, Ericsson M, Andrews NA, Mitsialis SA, Kourembanas S. Mesenchymal stromal cell-derived small extracellular vesicles restore lung architecture and improve exercise capacity in a model of neonatal hyperoxia-induced lung injury. J Extracell Vesicles. 2020 Jul 13; 9(1):1790874. PMID: 32939235.
    Citations: 23     Fields:    
  8. Mansouri N, Willis GR, Fernandez-Gonzalez A, Reis M, Nassiri S, Mitsialis SA, Kourembanas S. Mesenchymal stromal cell exosomes prevent and revert experimental pulmonary fibrosis through modulation of monocyte phenotypes. JCI Insight. 2019 11 01; 4(21). PMID: 31581150.
    Citations: 71     Fields:    Translation:HumansAnimalsCells
  9. Vitali SH, Fernandez-Gonzalez A, Nadkarni J, Kwong A, Rose C, Mitsialis SA, Kourembanas S. Heme oxygenase-1 dampens the macrophage sterile inflammasome response and regulates its components in the hypoxic lung. Am J Physiol Lung Cell Mol Physiol. 2020 01 01; 318(1):L125-L134. PMID: 31664855.
    Citations: 8     Fields:    Translation:AnimalsCells
  10. Hudalla H, Michael Z, Christodoulou N, Willis GR, Fernandez-Gonzalez A, Filatava EJ, Dieffenbach P, Fredenburgh LE, Stearman RS, Geraci MW, Kourembanas S, Christou H. Carbonic Anhydrase Inhibition Ameliorates Inflammation and Experimental Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2019 10; 61(4):512-524. PMID: 30951642; PMCID: PMC6775956.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  11. Willis GR, Fernandez-Gonzalez A, Reis M, Mitsialis SA, Kourembanas S. Macrophage Immunomodulation: The Gatekeeper for Mesenchymal Stem Cell Derived-Exosomes in Pulmonary Arterial Hypertension? Int J Mol Sci. 2018 Aug 27; 19(9). PMID: 30150544.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  12. Legchenko E, Chouvarine P, Borchert P, Fernandez-Gonzalez A, Snay E, Meier M, Maegel L, Mitsialis SA, Rog-Zielinska EA, Kourembanas S, Jonigk D, Hansmann G. PPAR? agonist pioglitazone reverses pulmonary hypertension and prevents right heart failure via fatty acid oxidation. Sci Transl Med. 2018 04 25; 10(438). PMID: 29695452.
    Citations: 81     Fields:    Translation:HumansCells
  13. Mitsialis SA, Willis GR, Fernandez-Gonzalez A, Kourembanas S. Reply to Muraca et al.: Exosome Treatment of Bronchopulmonary Dysplasia: How Pure Should Your Exosome Preparation Be? Am J Respir Crit Care Med. 2018 04 01; 197(7):970. PMID: 29160730; PMCID: PMC6020415.
    Citations: 3     Fields:    Translation:HumansCells
  14. Willis GR, Fernandez-Gonzalez A, Anastas J, Vitali SH, Liu X, Ericsson M, Kwong A, Mitsialis SA, Kourembanas S. Mesenchymal Stromal Cell Exosomes Ameliorate Experimental Bronchopulmonary Dysplasia and Restore Lung Function through Macrophage Immunomodulation. Am J Respir Crit Care Med. 2018 01 01; 197(1):104-116. PMID: 28853608; PMCID: PMC5765387.
    Citations: 205     Fields:    Translation:HumansAnimalsCells
  15. Vitali SH, Hansmann G, Rose C, Fernandez-Gonzalez A, Scheid A, Mitsialis SA, Kourembanas S. The Sugen 5416/hypoxia mouse model of pulmonary hypertension revisited: long-term follow-up. Pulm Circ. 2014 Dec; 4(4):619-29. PMID: 25610598; PMCID: PMC4278622.
    Citations: 56     
  16. Lee C, Mitsialis SA, Aslam M, Vitali SH, Vergadi E, Konstantinou G, Sdrimas K, Fernandez-Gonzalez A, Kourembanas S. Exosomes mediate the cytoprotective action of mesenchymal stromal cells on hypoxia-induced pulmonary hypertension. Circulation. 2012 Nov 27; 126(22):2601-11. PMID: 23114789; PMCID: PMC3979353.
    Citations: 347     Fields:    Translation:HumansAnimalsCells
  17. Hansmann G, Fernandez-Gonzalez A, Aslam M, Vitali SH, Martin T, Mitsialis SA, Kourembanas S. Mesenchymal stem cell-mediated reversal of bronchopulmonary dysplasia and associated pulmonary hypertension. Pulm Circ. 2012 Apr-Jun; 2(2):170-81. PMID: 22837858.
    Citations: 94     
  18. Fernandez-Gonzalez A, Alex Mitsialis S, Liu X, Kourembanas S. Vasculoprotective effects of heme oxygenase-1 in a murine model of hyperoxia-induced bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2012 Apr 15; 302(8):L775-84. PMID: 22287607.
    Citations: 16     Fields:    Translation:HumansAnimals
  19. Vergadi E, Chang MS, Lee C, Liang OD, Liu X, Fernandez-Gonzalez A, Mitsialis SA, Kourembanas S. Early macrophage recruitment and alternative activation are critical for the later development of hypoxia-induced pulmonary hypertension. Circulation. 2011 May 10; 123(18):1986-95. PMID: 21518986; PMCID: PMC3125055.
    Citations: 110     Fields:    Translation:HumansAnimalsCells
  20. Liang OD, Mitsialis SA, Chang MS, Vergadi E, Lee C, Aslam M, Fernandez-Gonzalez A, Liu X, Baveja R, Kourembanas S. Mesenchymal stromal cells expressing heme oxygenase-1 reverse pulmonary hypertension. Stem Cells. 2011 Jan; 29(1):99-107. PMID: 20957739.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  21. Aslam M, Baveja R, Liang OD, Fernandez-Gonzalez A, Lee C, Mitsialis SA, Kourembanas S. Bone marrow stromal cells attenuate lung injury in a murine model of neonatal chronic lung disease. Am J Respir Crit Care Med. 2009 Dec 01; 180(11):1122-30. PMID: 19713447; PMCID: PMC2784417.
    Citations: 227     Fields:    Translation:AnimalsCells
  22. Vitali SH, Mitsialis SA, Liang OD, Liu X, Fernandez-Gonzalez A, Christou H, Wu X, McGowan FX, Kourembanas S. Divergent cardiopulmonary actions of heme oxygenase enzymatic products in chronic hypoxia. PLoS One. 2009 Jun 19; 4(6):e5978. PMID: 19543386.
    Citations: 15     Fields:    Translation:AnimalsCells
  23. Fernandez-Gonzalez A, Kourembanas S, Wyatt TA, Mitsialis SA. Mutation of murine adenylate kinase 7 underlies a primary ciliary dyskinesia phenotype. Am J Respir Cell Mol Biol. 2009 Mar; 40(3):305-13. PMID: 18776131.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  24. Angeles Fernandez-Gonzalez, Stella Kourembanas, Todd A. Wyatt , & S. Alex Mitsialis. Mutation of murine Adenylate Kinase 7 underlies a primary ciliary dyskinesia phenotype. Am. J. Res. Cell Mol. Biol. 2008; (Advanced Online Publication).
  25. A. Fernandez-Gonzalez, S. Kourembanas & S. A. Mitsialis. An animal model for Primary Ciliary Dyskinesia (PCD) based on the disruption of a novel murine gene. American Thoracic Society International Conference, San Francisco, California. 2007.
  26. Anttila V, Christou H, Hagino I, Iwata Y, Mettler BA, Fernandez-Gonzalez A, Zurakowski D, Jonas RA. Cerebral endothelial nitric oxide synthase expression is reduced after very-low-flow bypass. Ann Thorac Surg. 2006 Jun; 81(6):2202-6. PMID: 16731155.
    Citations: 3     Fields:    Translation:Animals
  27. Fernandez-Gonzalez A, Naghshineh S, Mitsialis A and Kourembanas S. . Heme Oxygenase-1 (HO-1) overexpression prevents fibrosis and iron deposition in developmental lung injury. American Thoracic Society International Conference, San Diego, California. 2006.
  28. Vesa Anttila,MD, Helen Christou,MD, Ikuo Hagino,MD, Yusuke Iwata, MD, Bret A. Mettler, MD, Angeles Fernandez-Gonzalez, PhD, David Zurakowski, PhD, and Richard A. Jonas, MD. Cerebral endothelial nitric oxide synthase expression is reduced after very low flow bypass. Ann. Thorac.Surg. 2006; 81:2202-2206.
  29. Vitali SH, Mitsialis SA, Christou H, Fernandez-Gonzalez A, Liu X, Kourembanas S. Mechanisms of heme oxygenase-1-mediated cardiac and pulmonary vascular protection in chronic hypoxia: roles of carbon monoxide and bilirubin. Chest. 2005 Dec; 128(6 Suppl):578S-579S. PMID: 16373841.
    Citations: 2     Fields:    Translation:Animals
  30. Fernandez-Gonzalez A, Naghshineh S, Mitsialis A and Kourembanas S. . Heme oxygenase-1 overexpression decreases alveolar remodeling and iron deposition in developmental lung injury. HO Conference: The fourth International Congress,Boston, MA. 2005.
  31. Fernandez-Gonzalez A, La Spada AR, Treadaway J, Higdon JC, Harris BS, Sidman RL, Morgan JI, Zuo J. Purkinje cell degeneration (pcd) phenotypes caused by mutations in the axotomy-induced gene, Nna1. Science. 2002 Mar 08; 295(5561):1904-6. PMID: 11884758.
    Citations: 95     Fields:    Translation:AnimalsCells
  32. Tomomura M, Fernandez-Gonzalez A, Yano R and Yuzaki M. Characterization of the apoptosis-associated tyrosine kinase (AATYK) expressed in the CNS. Oncogene. 2001; 20:1022-1032.
  33. Tharp R, Fernandez-Gonzalez A, Faherty C, Smeyne M, Parris, J, Morgan J I and Smeyne R. . Genetic and Environmental aspects of the MPTP model of Parkinson’s Disease. 7th National Parkinson foundation International Symposium on Parkinson’s disease research, San Diego, California. 2001.
  34. Fernandez-Gonzalez A, Pérez-Otaño I, Morgan JI. MPTP selectively induces haem oxygenase-1 expression in striatal astrocytes. Eur J Neurosci. 2000 May; 12(5):1573-83. PMID: 10792435.
    Citations: 11     Fields:    Translation:AnimalsCells
  35. Hamre KM, Tharp R, Fernandez-Gonzalez A, Smeyne RJ. . The role of genotype and sex MPTP-induced degeneration in the substantia nigra of mice. 27th American Society for Neuroscience, New Orleans, La. 1997.
  36. Fernandez-Gonzalez AL, España A, Redondo P. Solid tumors after heart transplantation. Ann Thorac Surg. 1996 Sep; 62(3):943-4. PMID: 8784049.
    Citations:    Fields:    Translation:Humans
  37. Fernandez GA, De Ceballos ML, Jenner, P, Marsden CD. Alterations in peptide levels In Parkinson’s disease and incidental Lewy Body disease. Brain. 1996; 119:823-830.
  38. Fernandez, GA, Jenner P, Marsden CD, and De Ceballos ML. Characterization of neurotensin-like immunoreactivity in human basal ganglia: increased neurotensin levels, in substantia nigra in Parkinson’s disease. Peptide. 1995; 16:339-346.
  39. Fernandez A, Schneider JS. . Factors affecting striatal dopamine release in normal, symptomatic and recovered MPTP-treated cats. An in vivo microdialysis study. 25thAmerican Society for Neuroscience, San Diego, California. 1995.
  40. De Ceballos ML, Fernandez GA, Jenner P, Marsden CD. Parallel alterations in metenkephalin and substance P levels in medial globus pallidus in Parkinson’s disease patients. Neurosci Lett. 1993; 160:163-166.
  41. De Ceballos ML, Fernandez MA, Jenner P, Marsden CD. . Neuropeptide receptors are decreased in basal ganglia from Parkinson’s disease patients. 7th International Cathecolamine symposium, Amsterdam. 1992.
  42. De Ceballos ML, Fernandez MA, Jenner P, Marsden. . Basal ganglia neuropeptide alterations in Parkinson’s disease and controls bearing Lewy Bodies. Strategies for studying CNS active Compounds: Models, Screens and Clinical Syndromes, Madrid. 1992.
  43. Fernandez GA, De Ceballos ML, Jenner P, Marsden CD. Striatal neuropeptide levels Parkinson’s disease patients. Neurosci Lett. 1992; 145:171-174.
  44. De Ceballos ML, Fernandez MA, Perez-Otano I, Del Rio J. . Distribution of Neuropeptides in human brain after HPLC purification. III Congress of the SEN, Sevilla. 1989.
  45. Fernandez-Moreno MD, Fernandez-Gonzalez MA, Lopez-Luna MP, Prieto JC. Interaction of insulin with small intestinal epithelial cells from developing rats. Biology of the Neonate. 1988; 54:280-293.
  46. Fernandez-Moreno MD, Diaz-Juarez JL, Fernandez-Gonzalez MA, Sanchez- Franco F, Prieto JC. The vasoactive intestinal peptide receptor/effector system is developmentally regulated in rat jejuno ileal epithelial cells. Biochem. Int. 1988; 16:332-337.
  47. Fernandez-Moreno, Fernandez-Gonzalez MA, Arilla E, Lorenzo MJ, Prieto JC. Ileal levels and VIP receptor/effector system in ileal epithelial cells after colectomy in the rat. Biochem. Med. Met. Biol. 1987; 38:213-218.
  48. Fernandez-Gonzalez MA, Barrios V, Sancho JI, Carmena MJ, Tresguerres JAF, Prieto JC. Tissue plasma distribution of exogenous growth hormone-releasing factor. Analogue after venous, subcutaneous and intraperitoneal injection in the rat. Gen. Pharmacol. 1987; 18:551-554.
  49. Carmena MJ, Sancho JI, Fernandez-Gonzalez MA, Escudero F, Prieto JC . Somatostatin inhibits VIP and isoproterenol-stimulated cyclic AMP accumulation in rat prostatic epithelial cells. FEBS Lett. 1987; 218:73-76.
  50. Fernandez-Moreno MD, Fernandez-Gonzalez MA, Prieto JC . Effect of starvation on insulin binding to rat intestinal epithelial cells. IRCS Med. Sci. Biochem. 1986; 14:715-716.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.