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Leo Cheng, Ph.D.


Metabolic Characterization of Human Oral Squamous Cell Carcinoma Using Tissue Magnetic Resonance Spectroscopy
Summer, 06/24/05 - 08/19/05

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG070257 (CHENG, LEO L) Feb 15, 2021 - Jan 31, 2026
    Metabolomic characterization of normal aging and Alzheimer's disease under anesthesia- surgery stimuli
    Role: Principal Investigator
  2. R21CA243255 (CHENG, LEO L) Jun 15, 2019 - May 31, 2021
    Identification of prostate cancer aggressiveness using hyperpolarized polyamine metabolic rates
    Role: Principal Investigator
  3. S10OD023406 (CHENG, LEO L) Mar 17, 2017 - Mar 16, 2020
    Upgrade of Console for 600 MHz MR Spectrometer
    Role: Principal Investigator
  4. R21CA162959 (CHENG, LEO L) Sep 14, 2011 - Aug 31, 2013
    Development of Metabolomic and Molecular Probes for Prostate Cancer Assessment
    Role: Principal Investigator
  5. R21CA141139 (CHENG, LEO L) Jan 1, 2010 - Dec 31, 2012
    Detection of Lung Cancer Risks for Serum Metabolomics
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Paskaranandavadivel N, Varghese C, Lara J, Ramachandran S, Cheng L, Holobar A, Gharibans A, Bissett I, Collinson R, Stinear C, O'Grady G. A Novel High-Density Electromyography Probe for Evaluating Anorectal Neurophysiology: Design, Human Feasibility Study, and Validation with Trans-Sacral Magnetic Stimulation. Ann Biomed Eng. 2021 Jan; 49(1):502-514. PMID: 32737639.
    Citations:    Fields:    
  2. Miller KJW, Cheng LK, Angeli TR, Avci R, Paskaranandavadivel N. Design and Application of an Inflatable Cuff to Aid High-Resolution Intestinal Slow Wave Recordings. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:3953-3956. PMID: 33018865.
  3. Han H, Cheng LK, Avci R, Paskaranandavadivel N. Detection of Slow Wave Propagation Direction Using Bipolar High-Resolution Recordings. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:837-840. PMID: 33018115.
    Citations:    Translation:Animals
  4. Berker Y, Vandergrift LA, Wagner I, Su L, Kurth J, Schuler A, Dinges SS, Habbel P, Nowak J, Mark E, Aryee MJ, Christiani DC, Cheng LL. Magnetic Resonance Spectroscopy-based Metabolomic Biomarkers for Typing, Staging, and Survival Estimation of Early-Stage Human Lung Cancer. Sci Rep. 2019 07 16; 9(1):10319. PMID: 31311965.
    Citations: 2     Fields:    Translation:Humans
  5. Cherian Abraham A, Cheng LK, Angeli TR, Alighaleh S, Paskaranandavadivel N. Dynamic slow-wave interactions in the rabbit small intestine defined using high-resolution mapping. Neurogastroenterol Motil. 2019 09; 31(9):e13670. PMID: 31250520.
    Citations:    Fields:    Translation:Animals
  6. Cheng LL. Response to re: Metabolomic prostate cancer fields in HRMAS MRS-profiled histologically benign tissue vary with cancer status and distance from cancer. Dinges et al., NBM 2019. NMR Biomed. 2019 08; 32(8):e4120. PMID: 31172612.
    Citations:    Fields:    Translation:Humans
  7. Dinges SS, Hohm A, Vandergrift LA, Nowak J, Habbel P, Kaltashov IA, Cheng LL. Cancer metabolomic markers in urine: evidence, techniques and recommendations. Nat Rev Urol. 2019 06; 16(6):339-362. PMID: 31092915.
    Citations: 15     Fields:    Translation:Humans
  8. Du P, Grady GO, Paskaranandavadivel N, Tang SJ, Abell T, Cheng LK. High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias. J Neurogastroenterol Motil. 2019 Apr 30; 25(2):276-285. PMID: 30870879.
    Citations: 1     
  9. Alighaleh S, Cheng LK, Angeli TR, Amiri M, Sathar S, O'Grady G, Paskaranandavadivel N. A Novel Gastric Pacing Device to Modulate Slow Waves and Assessment by High-Resolution Mapping. IEEE Trans Biomed Eng. 2019 10; 66(10):2823-2830. PMID: 30735980.
    Citations:    Fields:    Translation:Animals
  10. Dinges SS, Vandergrift LA, Wu S, Berker Y, Habbel P, Taupitz M, Wu CL, Cheng LL. Metabolomic prostate cancer fields in HRMAS MRS-profiled histologically benign tissue vary with cancer status and distance from cancer. NMR Biomed. 2019 10; 32(10):e4038. PMID: 30609175.
    Citations:    Fields:    Translation:Humans
  11. Tilgner M, Vater TS, Habbel P, Cheng LL. High-Resolution Magic Angle Spinning (HRMAS) NMR Methods in Metabolomics. Methods Mol Biol. 2019; 2037:49-67. PMID: 31463839.
    Citations:    Fields:    Translation:Humans
  12. Yazdani H, Cheng LL, Christiani DC, Yazdani A. Bounded Fuzzy Possibilistic Method Reveals Information about Lung Cancer through Analysis of Metabolomics. IEEE/ACM Trans Comput Biol Bioinform. 2020 Mar-Apr; 17(2):526-535. PMID: 30222581.
    Citations:    Fields:    Translation:Humans
  13. Zhang H, Yu H, Walcott GP, Paskaranandavadivel N, Cheng LK, O'Grady G, Rogers JM. High-resolution optical mapping of gastric slow wave propagation. Neurogastroenterol Motil. 2019 01; 31(1):e13449. PMID: 30129082.
    Citations: 2     Fields:    Translation:Animals
  14. Vandergrift LA, Decelle EA, Kurth J, Wu S, Fuss TL, DeFeo EM, Halpern EF, Taupitz M, McDougal WS, Olumi AF, Wu CL, Cheng LL. Metabolomic Prediction of Human Prostate Cancer Aggressiveness: Magnetic Resonance Spectroscopy of Histologically Benign Tissue. Sci Rep. 2018 03 26; 8(1):4997. PMID: 29581441.
    Citations: 7     Fields:    Translation:Humans
  15. Kurreck A, Vandergrift LA, Fuss TL, Habbel P, Agar NYR, Cheng LL. Prostate cancer diagnosis and characterization with mass spectrometry imaging. Prostate Cancer Prostatic Dis. 2018 09; 21(3):297-305. PMID: 29209003.
    Citations: 2     Fields:    Translation:Humans
  16. Zifan A, Kumar D, Cheng LK, Mittal RK. Three-Dimensional Myoarchitecture of the Lower Esophageal Sphincter and Esophageal Hiatus Using Optical Sectioning Microscopy. Sci Rep. 2017 10 13; 7(1):13188. PMID: 29030643.
    Citations: 6     Fields:    Translation:Humans
  17. Dietz C, Ehret F, Palmas F, Vandergrift LA, Jiang Y, Schmitt V, Dufner V, Habbel P, Nowak J, Cheng LL. Applications of high-resolution magic angle spinning MRS in biomedical studies II-Human diseases. NMR Biomed. 2017 Nov; 30(11). PMID: 28915318.
    Citations: 5     Fields:    Translation:Humans
  18. Lin AY, Du P, Dinning PG, Arkwright JW, Kamp JP, Cheng LK, Bissett IP, O'Grady G. High-resolution anatomic correlation of cyclic motor patterns in the human colon: Evidence of a rectosigmoid brake. Am J Physiol Gastrointest Liver Physiol. 2017 May 01; 312(5):G508-G515. PMID: 28336544.
    Citations: 13     Fields:    Translation:Humans
  19. Kaebisch E, Fuss TL, Vandergrift LA, Toews K, Habbel P, Cheng LL. Applications of high-resolution magic angle spinning MRS in biomedical studies I-cell line and animal models. NMR Biomed. 2017 Jun; 30(6). PMID: 28301071.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  20. Zhou IY, Fuss TL, Igarashi T, Jiang W, Zhou X, Cheng LL, Sun PZ. Tissue Characterization with Quantitative High-Resolution Magic Angle Spinning Chemical Exchange Saturation Transfer Z-Spectroscopy. Anal Chem. 2016 11 01; 88(21):10379-10383. PMID: 27709896.
    Citations: 4     Fields:    Translation:Animals
  21. Fuss TL, Cheng LL. Metabolic Imaging in Humans. Top Magn Reson Imaging. 2016 Oct; 25(5):223-235. PMID: 27748708.
    Citations: 2     Fields:    Translation:Humans
  22. Angeli TR, Du P, Midgley D, Paskaranandavadivel N, Sathar S, Lahr C, Abell TL, Cheng LK, O'Grady G. Acute Slow Wave Responses to High-Frequency Gastric Electrical Stimulation in Patients With Gastroparesis Defined by High-Resolution Mapping. Neuromodulation. 2016 Dec; 19(8):864-871. PMID: 27284964.
    Citations: 6     Fields:    Translation:Humans
  23. Paskaranandavadivel N, OGrady G, Cheng LK. Time-Delay Mapping of High-Resolution Gastric Slow-Wave Activity. IEEE Trans Biomed Eng. 2017 01; 64(1):166-172. PMID: 27071158.
    Citations: 2     Fields:    Translation:HumansAnimals
  24. Fuss TL, Cheng LL. Evaluation of Cancer Metabolomics Using ex vivo High Resolution Magic Angle Spinning (HRMAS) Magnetic Resonance Spectroscopy (MRS). Metabolites. 2016 Mar 22; 6(1). PMID: 27011205.
    Citations: 10     
  25. Bull SH, O'Grady G, Du P, Cheng LK. A system and method for online high-resolution mapping of gastric slow-wave activity. IEEE Trans Biomed Eng. 2014 Nov; 61(11):2679-87. PMID: 24860024.
    Citations: 7     Fields:    Translation:HumansAnimals
  26. Wu CC, Lin YM, Gao J, Winston JH, Cheng LK, Shi XZ. Are interstitial cells of Cajal involved in mechanical stress-induced gene expression and impairment of smooth muscle contractility in bowel obstruction? PLoS One. 2013; 8(9):e76222. PMID: 24098782.
    Citations: 5     Fields:    Translation:AnimalsCells
  27. Angeli TR, O'Grady G, Paskaranandavadivel N, Erickson JC, Du P, Pullan AJ, Bissett IP, Cheng LK. Experimental and Automated Analysis Techniques for High-resolution Electrical Mapping of Small Intestine Slow Wave Activity. J Neurogastroenterol Motil. 2013 Apr; 19(2):179-91. PMID: 23667749.
    Citations: 8     
  28. Spur EM, Decelle EA, Cheng LL. Metabolomic imaging of prostate cancer with magnetic resonance spectroscopy and mass spectrometry. Eur J Nucl Med Mol Imaging. 2013 Jul; 40 Suppl 1:S60-71. PMID: 23549758.
    Citations: 6     Fields:    Translation:Humans
  29. Decelle EA, Cheng LL. High-resolution magic angle spinning 1H MRS in prostate cancer. NMR Biomed. 2014 Jan; 27(1):90-9. PMID: 23529951.
    Citations: 8     Fields:    Translation:Humans
  30. O'Grady G, Angeli TR, Du P, Lahr C, Lammers WJEP, Windsor JA, Abell TL, Farrugia G, Pullan AJ, Cheng LK. Abnormal initiation and conduction of slow-wave activity in gastroparesis, defined by high-resolution electrical mapping. Gastroenterology. 2012 Sep; 143(3):589-598.e3. PMID: 22643349.
    Citations: 86     Fields:    Translation:HumansCells
  31. Jordan KW, Adkins CB, Cheng LL, Faquin WC. Application of magnetic-resonance-spectroscopy- based metabolomics to the fine-needle aspiration diagnosis of papillary thyroid carcinoma. Acta Cytol. 2011; 55(6):584-9. PMID: 22156470.
    Citations: 10     Fields:    Translation:Humans
  32. Kurth J, Defeo E, Cheng LL. Magnetic resonance spectroscopy: a promising tool for the diagnostics of human prostate cancer? Urol Oncol. 2011 Sep-Oct; 29(5):562-71. PMID: 21930088.
    Citations: 3     Fields:    Translation:Humans
  33. DeFeo EM, Wu CL, McDougal WS, Cheng LL. A decade in prostate cancer: from NMR to metabolomics. Nat Rev Urol. 2011 May 17; 8(6):301-11. PMID: 21587223.
    Citations: 19     Fields:    Translation:HumansAnimals
  34. Paskaranandavadivel N, Cheng LK, Du P, O'Grady G, Pullan AJ. Improved signal processing techniques for the analysis of high resolution serosal slow wave activity in the stomach. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:1737-40. PMID: 22254662.
    Citations: 25     Translation:Humans
  35. Bull SH, O'Grady G, Cheng LK, Pullan AJ. A framework for the online analysis of multi-electrode gastric slow wave recordings. Annu Int Conf IEEE Eng Med Biol Soc. 2011; 2011:1741-4. PMID: 22254663.
    Citations: 8     Translation:Humans
  36. Erickson JC, O'Grady G, Du P, Egbuji JU, Pullan AJ, Cheng LK. Automated gastric slow wave cycle partitioning and visualization for high-resolution activation time maps. Ann Biomed Eng. 2011 Jan; 39(1):469-83. PMID: 20927594.
    Citations: 32     Fields:    Translation:Animals
  37. DeFeo EM, Cheng LL. Characterizing human cancer metabolomics with ex vivo 1H HRMAS MRS. Technol Cancer Res Treat. 2010 Aug; 9(4):381-91. PMID: 20626203.
    Citations: 10     Fields:    Translation:Humans
  38. O'Grady G, Du P, Cheng LK, Egbuji JU, Lammers WJ, Windsor JA, Pullan AJ. Origin and propagation of human gastric slow-wave activity defined by high-resolution mapping. Am J Physiol Gastrointest Liver Physiol. 2010 Sep; 299(3):G585-92. PMID: 20595620.
    Citations: 79     Fields:    Translation:Humans
  39. Maxeiner A, Adkins CB, Zhang Y, Taupitz M, Halpern EF, McDougal WS, Wu CL, Cheng LL. Retrospective analysis of prostate cancer recurrence potential with tissue metabolomic profiles. Prostate. 2010 May 15; 70(7):710-7. PMID: 20017167.
    Citations: 17     Fields:    Translation:Humans
  40. Kaul D, Wu CL, Adkins CB, Jordan KW, Defeo EM, Habbel P, Peterson RT, McDougal WS, Pohl U, Cheng LL. Assessing prostate cancer growth with mRNA of spermine metabolic enzymes. . 2010 May 01; 9(9):736-42. PMID: 20215859.
    Citations: 4     Translation:Humans
  41. Wu CL, Jordan KW, Ratai EM, Sheng J, Adkins CB, Defeo EM, Jenkins BG, Ying L, McDougal WS, Cheng LL. Metabolomic imaging for human prostate cancer detection. Sci Transl Med. 2010 Jan 27; 2(16):16ra8. PMID: 20371475.
    Citations: 16     Fields:    Translation:Humans
  42. Erickson JC, O'Grady G, Du P, Obioha C, Qiao W, Richards WO, Bradshaw LA, Pullan AJ, Cheng LK. Falling-edge, variable threshold (FEVT) method for the automated detection of gastric slow wave events in high-resolution serosal electrode recordings. Ann Biomed Eng. 2010 Apr; 38(4):1511-29. PMID: 20024624.
    Citations: 44     Fields:    Translation:Animals
  43. Jordan KW, Nordenstam J, Lauwers GY, Rothenberger DA, Alavi K, Garwood M, Cheng LL. Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy. Dis Colon Rectum. 2009 Mar; 52(3):520-5. PMID: 19333056.
    Citations: 27     Fields:    Translation:Humans
  44. Du P, Qiao W, O'Grady G, Egbuji JU, Lammers W, Cheng LK, Pullan AJ. Automated detection of gastric slow wave events and estimation of propagation velocity vector fields from serosal high-resolution mapping. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:2527-30. PMID: 19964973.
    Citations: 9     Translation:AnimalsCells
  45. Jordan KW, Cheng LL. NMR-based metabolomics approach to target biomarkers for human prostate cancer. Expert Rev Proteomics. 2007 Jun; 4(3):389-400. PMID: 17552923.
    Citations: 12     Fields:    Translation:Humans
  46. Jordan KW, He W, Halpern EF, Wu CL, Cheng LL. Evaluation of Tissue Metabolites with High Resolution Magic Angle Spinning MR Spectroscopy Human Prostate Samples After Three-Year Storage at -80 degrees C. Biomark Insights. 2007 Apr 18; 2:147-54. PMID: 19662199.
    Citations: 11     
  47. Loening NM, Chamberlin AM, Zepeda AG, Gonzalez RG, Cheng LL. Quantification of phosphocholine and glycerophosphocholine with 31P edited 1H NMR spectroscopy. NMR Biomed. 2005 Nov; 18(7):413-20. PMID: 16075415.
    Citations: 11     Fields:    Translation:HumansCells
  48. Burns MA, Taylor JL, Wu CL, Zepeda AG, Bielecki A, Cory D, Cheng LL. Reduction of spinning sidebands in proton NMR of human prostate tissue with slow high-resolution magic angle spinning. Magn Reson Med. 2005 Jul; 54(1):34-42. PMID: 15968646.
    Citations: 9     Fields:    Translation:Humans
  49. Cheng LL, Burns MA, Taylor JL, He W, Halpern EF, McDougal WS, Wu CL. Metabolic characterization of human prostate cancer with tissue magnetic resonance spectroscopy. Cancer Res. 2005 Apr 15; 65(8):3030-4. PMID: 15833828.
    Citations: 53     Fields:    Translation:Humans
  50. Burns MA, He W, Wu CL, Cheng LL. Quantitative pathology in tissue MR spectroscopy based human prostate metabolomics. Technol Cancer Res Treat. 2004 Dec; 3(6):591-8. PMID: 15560717.
    Citations: 17     Fields:    Translation:Humans
  51. Wu CL, Taylor JL, He W, Zepeda AG, Halpern EF, Bielecki A, Gonzalez RG, Cheng LL. Proton high-resolution magic angle spinning NMR analysis of fresh and previously frozen tissue of human prostate. Magn Reson Med. 2003 Dec; 50(6):1307-11. PMID: 14648580.
    Citations: 13     Fields:    Translation:Humans
  52. Taylor JL, Wu CL, Cory D, Gonzalez RG, Bielecki A, Cheng LL. High-resolution magic angle spinning proton NMR analysis of human prostate tissue with slow spinning rates. Magn Reson Med. 2003 Sep; 50(3):627-32. PMID: 12939772.
    Citations: 23     Fields:    Translation:Humans
  53. Cheng LL, Newell K, Mallory AE, Hyman BT, Gonzalez RG. Quantification of neurons in Alzheimer and control brains with ex vivo high resolution magic angle spinning proton magnetic resonance spectroscopy and stereology. Magn Reson Imaging. 2002 Sep; 20(7):527-33. PMID: 12413598.
    Citations: 29     Fields:    Translation:HumansCells
  54. Tzika AA, Cheng LL, Goumnerova L, Madsen JR, Zurakowski D, Astrakas LG, Zarifi MK, Scott RM, Anthony DC, Gonzalez RG, Black PM. Biochemical characterization of pediatric brain tumors by using in vivo and ex vivo magnetic resonance spectroscopy. J Neurosurg. 2002 Jun; 96(6):1023-31. PMID: 12066902.
    Citations: 20     Fields:    Translation:Humans
  55. Cheng LL, Wu C, Smith MR, Gonzalez RG. Non-destructive quantitation of spermine in human prostate tissue samples using HRMAS 1H NMR spectroscopy at 9.4 T. FEBS Lett. 2001 Apr 06; 494(1-2):112-6. PMID: 11297745.
    Citations: 38     Fields:    Translation:Humans
  56. Cheng LL, Chang IW, Smith BL, Gonzalez RG. Evaluating human breast ductal carcinomas with high-resolution magic-angle spinning proton magnetic resonance spectroscopy. J Magn Reson. 1998 Nov; 135(1):194-202. PMID: 9799694.
    Citations: 33     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.