Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Harvard Catalyst Profiles is currently experiencing a partial system outage. Login/Edit modules are currently disabled.

Xiaobo Zhou, Ph.D.

Title
Institution
Department
Address
Phone

Biography
Peking Union Medical College, BeijingPh.D.07/2003Cell Biology

Overview
Dr. Zhou has been leading the Functional Genomics research team at the Brigham and Women’s Hospital, Harvard Medical School since 2009. Her group focuses on deciphering function of human genome, mainly genetic regions identified by genome-wide association studies (GWAS) or eQTL analysis in respiratory diseases. Through interpreting biological meanings of GWAS findings, her lab aims to identify novel drug targets in complex pulmonary diseases.
To interpret biological meaning of genetic variants/regions associated with complex diseases, Dr. Zhou's group has established a pipeline to dissect local chromatin structure surrounding GWAS and eQTL SNPs, including ChIP, FAIRE (Formaldehyde-Assisted Isolation of Regulatory Elements), 3C (chromatin conformation capture) and 4C(chromatin conformation capture sequencing). We also recently applied a high-throughput screening to identify functional variants within GWAS loci by massively paralleled reporter assay (MPRA). The state-of-the-art genome editing method, mainly CRISPR/Cas-9 has also been routinely applied to identify functional regulatory variants in a semi-high-throughput way and to asses function of novel GWAS genes. Additionally, to pursue further mechanistic studies on GWAS candidate genes, her group characterized protein interactome in vitro and generated knockout and transgenic mouse lines in disease relevant murine models. In collaboration with multiple cross-functional groups, he group has identified functional variants in the HHIP and FAM13A two COPD GWAS loci and also identified novel druggable pathways associated with genetic predispositions in COPD.
Additionally, Functional Genomics Laboratory led by her has also developed customized experimental validations on networks built upon various human –omics datasets, including genomics, proteomics and genetics data.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL148667 (ZHOU, ANNY XIAOBO) Apr 5, 2020 - Mar 31, 2025
    NIH
    Integrative Characterization on the function of COPD GWAS gene, HHIP
    Role: Principal Investigator
  2. R01HL147148 (CHO, MICHAEL H.;SILVERMAN, EDWIN K ;ZHOU, ANNY XIAOBO) May 1, 2019 - Apr 30, 2024
    NIH
    Genetic and Functional Dissection of a Cluster of COPD GWAS Signals on Chromosome 4q
    Role: Co-PI
  3. R01HL137927 (SILVERMAN, EDWIN K) Aug 15, 2017 - Apr 30, 2021
    NIH
    Identifying functional variants in COPD GWAS loci
    Role: Co-PI
  4. R01HL127200 (ZHOU, ANNY XIAOBO) Apr 1, 2015 - Mar 31, 2020
    NIH
    HL-FAM13A Regulates the beta-catenin/Wnt Pathway in Chronic Obstructive Pulmonary Disease
    Role: Principal Investigator
  5. R33HL120794 (SILVERMAN, EDWIN K) Mar 1, 2014 - Feb 29, 2020
    NIH
    Functional Genomic Approaches to Dissect COPD GWAS Loci
    Role: Co-PI

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Updating...
This operation might take several minutes to complete. Please do not close your browser.
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Zhou's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (301)
Explore
_
Co-Authors (56)
Explore
_
Similar People (59)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.