Harvard Catalyst Profiles

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Brian Benjamin Hoffman, M.D.,C.M.

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01GM057545 (CLARK, DAVID J) Jan 1, 1999 - Jun 30, 2004
    NIH/NIGMS
    MECHANISMS FOR TOLERANCE TO ACTIONS OF A2 AGONISTS
    Role: Co-Principal Investigator
  2. P01HL048743 (MICHEL, THOMAS) Sep 30, 1992 - Mar 31, 2015
    NIH/NHLBI
    Arterial Dysfunction: Basic and Clinical Mechanisms
    Role: Co-Principal Investigator
  3. R01AG009597 (HOFFMAN, BRIAN B) Feb 15, 1991 - Jan 31, 1996
    NIH/NIA
    MOLECULAR PHARMACOLOGY OF ADRENERGIC RECEPTORS IN AGING
    Role: Principal Investigator
  4. R01HL041315 (HOFFMAN, BRIAN B) Jul 1, 1988 - May 31, 2005
    NIH/NHLBI
    ALPHA 1 ADRENERGIC RESPONSES IN SMOOTH MUSCLE
    Role: Principal Investigator
  5. R01AG005676 (HOFFMAN, BRIAN B) Aug 1, 1985 - Jul 31, 1989
    NIH/NIA
    REGULATION OF LIPOLYSIS WITH AGING
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tso GJ, Yuen K, Martins S, Tu SW, Ashcraft M, Heidenreich P, Hoffman BB, Goldstein MK. Test Case Selection in Pre-Deployment Testing of Complex Clinical Decision Support Systems. AMIA Jt Summits Transl Sci Proc. 2016; 2016:240-9. PMID: 27570678; PMCID: PMC5001770.
    Citations: 1     
  2. Zulman DM, Martins SB, Liu Y, Tu SW, Hoffman BB, Asch SM, Goldstein MK. Using a Clinical Knowledge Base to Assess Comorbidity Interrelatedness Among Patients with Multiple Chronic Conditions. AMIA Annu Symp Proc. 2015; 2015:1381-9. PMID: 26958279.
    Citations: 1     Fields:    Translation:Humans
  3. Zulman DM, Asch SM, Martins SB, Kerr EA, Hoffman BB, Goldstein MK. Quality of care for patients with multiple chronic conditions: the role of comorbidity interrelatedness. J Gen Intern Med. 2014 Mar; 29(3):529-37. PMID: 24081443; PMCID: PMC3930789.
    Citations: 30     Fields:    Translation:Humans
  4. Abiose AK, Aronow WS, Moreno H, Nair CK, Blaschke TF, Hoffman BB. Increased vascular alpha1-adrenergic sensitivity in patients with renal failure: receiving recombinant erythropoeitin. Am J Ther. 2007 Sep-Oct; 14(5):427-34. PMID: 17890929.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  5. Bosworth HB, Olsen MK, McCant F, Harrelson M, Gentry P, Rose C, Goldstein MK, Hoffman BB, Powers B, Oddone EZ. Hypertension Intervention Nurse Telemedicine Study (HINTS): testing a multifactorial tailored behavioral/educational and a medication management intervention for blood pressure control. Am Heart J. 2007 Jun; 153(6):918-24. PMID: 17540191.
    Citations: 25     Fields:    Translation:Humans
  6. Martins SB, Lai S, Tu S, Shankar R, Hastings SN, Hoffman BB, Dipilla N, Goldstein MK. Offline testing of the ATHENA Hypertension decision support system knowledge base to improve the accuracy of recommendations. AMIA Annu Symp Proc. 2006; 539-43. PMID: 17238399; PMCID: PMC1839611.
    Citations: 8     Fields:    Translation:Humans
  7. Lin ND, Martins SB, Chan AS, Coleman RW, Bosworth HB, Oddone EZ, Shankar RD, Musen MA, Hoffman BB, Goldstein MK. Identifying barriers to hypertension guideline adherence using clinician feedback at the point of care. AMIA Annu Symp Proc. 2006; 494-8. PMID: 17238390; PMCID: PMC1839712.
    Citations: 13     Fields:    Translation:Humans
  8. Goldstein MK, Lavori P, Coleman R, Advani A, Hoffman BB. Improving adherence to guidelines for hypertension drug prescribing: cluster-randomized controlled trial of general versus patient-specific recommendations. Am J Manag Care. 2005 Nov; 11(11):677-85. PMID: 16268751.
    Citations: 25     Fields:    Translation:Humans
  9. Chan AS, Shankar RD, Coleman RW, Matins SB, Hoffman BB, Goldstein MK. Leveraging point-of-care clinician feedback to study barriers to guideline adherence. AMIA Annu Symp Proc. 2005; 915. PMID: 16779202; PMCID: PMC1560728.
    Citations:    Fields:    Translation:Humans
  10. Steinman MA, Fischer MA, Shlipak MG, Bosworth HB, Oddone EZ, Hoffman BB, Goldstein MK. Clinician awareness of adherence to hypertension guidelines. Am J Med. 2004 Nov 15; 117(10):747-54. PMID: 15541324.
    Citations: 23     Fields:    Translation:Humans
  11. Goldstein MK, Coleman RW, Tu SW, Shankar RD, O'Connor MJ, Musen MA, Martins SB, Lavori PW, Shlipak MG, Oddone E, Advani AA, Gholami P, Hoffman BB. Translating research into practice: organizational issues in implementing automated decision support for hypertension in three medical centers. J Am Med Inform Assoc. 2004 Sep-Oct; 11(5):368-76. PMID: 15187064; PMCID: PMC516243.
    Citations: 24     Fields:    Translation:Humans
  12. Davies MF, Tsui J, Flannery JA, Li X, DeLorey TM, Hoffman BB. Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology. 2004 Feb; 29(2):229-39. PMID: 14583739.
    Citations: 17     Fields:    Translation:AnimalsCells
  13. Chan AS, Coleman RW, Martins SB, Advani A, Musen MA, Bosworth HB, Oddone EZ, Shlipak MG, Hoffman BB, Goldstein MK. Evaluating provider adherence in a trial of a guideline-based decision support system for hypertension. Stud Health Technol Inform. 2004; 107(Pt 1):125-9. PMID: 15360788.
    Citations:    Fields:    Translation:Humans
  14. Davies MF, Tsui JY, Flannery JA, Li X, DeLorey TM, Hoffman BB. Augmentation of the noradrenergic system in alpha-2 adrenergic receptor deficient mice: anatomical changes associated with enhanced fear memory. Brain Res. 2003 Oct 03; 986(1-2):157-65. PMID: 12965240.
    Citations: 5     Fields:    Translation:AnimalsCells
  15. Chen J, Hoffman BB, Isseroff RR. Beta-adrenergic receptor activation inhibits keratinocyte migration via a cyclic adenosine monophosphate-independent mechanism. J Invest Dermatol. 2002 Dec; 119(6):1261-8. PMID: 12485426.
    Citations: 13     Fields:    Translation:HumansCells
  16. Hu ZW, Kerb R, Shi XY, Wei-Lavery T, Hoffman BB. Angiotensin II increases expression of cyclooxygenase-2: implications for the function of vascular smooth muscle cells. J Pharmacol Exp Ther. 2002 Nov; 303(2):563-73. PMID: 12388637.
    Citations: 15     Fields:    Translation:HumansCells
  17. Szeto HC, Coleman RK, Gholami P, Hoffman BB, Goldstein MK. Accuracy of computerized outpatient diagnoses in a Veterans Affairs general medicine clinic. Am J Manag Care. 2002 Jan; 8(1):37-43. PMID: 11814171.
    Citations: 58     Fields:    Translation:Humans
  18. Goldstein MK, Hoffman BB, Coleman RW, Tu SW, Shankar RD, O'Connor M, Martins S, Martins S, Advani A, Musen MA. Patient safety in guideline-based decision support for hypertension management: ATHENA DSS. Proc AMIA Symp. 2001; 214-8. PMID: 11825183; PMCID: PMC2243380.
    Citations: 4     Fields:    Translation:Humans
  19. Chalon S, Moreno H, Benowitz NL, Hoffman BB, Blaschke TF. Nicotine impairs endothelium-dependent dilatation in human veins in vivo. Clin Pharmacol Ther. 2000 Apr; 67(4):391-7. PMID: 10801248.
    Citations: 19     Fields:    Translation:HumansCTClinical Trials
  20. Goldstein MK, Hoffman BB, Coleman RW, Musen MA, Tu SW, Advani A, Shankar R, O'Connor M. Implementing clinical practice guidelines while taking account of changing evidence: ATHENA DSS, an easily modifiable decision-support system for managing hypertension in primary care. Proc AMIA Symp. 2000; 300-4. PMID: 11079893; PMCID: PMC2243943.
    Citations: 26     Fields:    Translation:Humans
  21. Duchna HW, Guilleminault C, Stoohs RA, Faul JL, Moreno H, Hoffman BB, Blaschke TF. Vascular reactivity in obstructive sleep apnea syndrome. Am J Respir Crit Care Med. 2000 Jan; 161(1):187-91. PMID: 10619819.
    Citations: 15     Fields:    Translation:Humans
  22. Hu JS, Durst M, Kerb R, Truong V, Ma JT, Khurgin E, Balaban D, Gingeras TR, Hoffman BB. Analysis of drug pharmacology towards predicting drug behavior by expression profiling using high-density oligonucleotide arrays. Ann N Y Acad Sci. 2000; 919:9-15. PMID: 11083092.
    Citations: 1     Fields:    Translation:HumansCells
  23. Hu ZW, Hoffman BB. Nuclear run-on assays for measurement of adrenergic receptor transcription rate. Methods Mol Biol. 2000; 126:169-80. PMID: 10685409.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  24. Hoffman BB, Hu ZW. Alpha(1)-adrenoceptors (alpha(1)-AR) and vascular smooth muscle cell growth. Prostate Suppl. 2000; 9:29-33. PMID: 11056500.
    Citations: 2     Fields:    Translation:Humans
  25. Tangphao O, Chalon S, Moreno HJ, Abiose AK, Blaschke TF, Hoffman BB. Heparin-induced vasodilation in human hand veins. Clin Pharmacol Ther. 1999 Sep; 66(3):232-8. PMID: 10511058.
    Citations: 2     Fields:    Translation:Humans
  26. Han DC, Isono M, Hoffman BB, Ziyadeh FN. High glucose stimulates proliferation and collagen type I synthesis in renal cortical fibroblasts: mediation by autocrine activation of TGF-beta. J Am Soc Nephrol. 1999 Sep; 10(9):1891-9. PMID: 10477140.
    Citations: 23     Fields:    Translation:AnimalsCells
  27. Hu ZW, Shi XY, Lin RZ, Chen J, Hoffman BB. alpha1-Adrenergic receptor stimulation of mitogenesis in human vascular smooth muscle cells: role of tyrosine protein kinases and calcium in activation of mitogen-activated protein kinase. J Pharmacol Exp Ther. 1999 Jul; 290(1):28-37. PMID: 10381756.
    Citations: 13     Fields:    Translation:HumansCells
  28. Chen J, Lin R, Hu ZW, Hoffman BB. alpha1-adrenergic receptor activation of c-fos expression in transfected rat-1 fibroblasts: role of Ca2+. J Pharmacol Exp Ther. 1999 Jun; 289(3):1376-84. PMID: 10336529.
    Citations: 2     Fields:    Translation:AnimalsCells
  29. Chalon S, Moreno H, Hoffman BB, Blaschke TF. Angiotensin-converting enzyme inhibition improves venous endothelial dysfunction in chronic smokers. Clin Pharmacol Ther. 1999 Mar; 65(3):295-303. PMID: 10096262.
    Citations: 6     Fields:    Translation:Humans
  30. Tangphao O, Grossmann M, Chalon S, Hoffman BB, Blaschke TF. Pharmacokinetics of intravenous and oral L-arginine in normal volunteers. Br J Clin Pharmacol. 1999 Mar; 47(3):261-6. PMID: 10215749; PMCID: PMC2014227.
    Citations: 12     Fields:    Translation:HumansCTClinical Trials
  31. Tangphao O, Chalon S, Moreno H, Hoffman BB, Blaschke TF. Pharmacokinetics of L-arginine during chronic administration to patients with hypercholesterolaemia. Clin Sci (Lond). 1999 Feb; 96(2):199-207. PMID: 9918901.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  32. Hu ZW, Shi XY, Lin RZ, Hoffman BB. Contrasting signaling pathways of alpha1A- and alpha1B-adrenergic receptor subtype activation of phosphatidylinositol 3-kinase and Ras in transfected NIH3T3 cells. Mol Endocrinol. 1999 Jan; 13(1):3-14. PMID: 9892008.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  33. Chalon S, Bedarida GV, Moreno H, Tejura B, Urae A, Hoffman BB, Blaschke TF. Inhibition of angiotensin-converting enzyme in human hand veins. Clin Pharmacol Ther. 1999 Jan; 65(1):58-65. PMID: 9951431.
    Citations: 1     Fields:    Translation:Humans
  34. Chalon S, Tejura B, Moreno H, Urae A, Blaschke TF, Hoffman BB. Role of nitric oxide in isoprenaline and sodium nitroprusside-induced relaxation in human hand veins. Br J Clin Pharmacol. 1999 Jan; 47(1):91-8. PMID: 10073745; PMCID: PMC2014212.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  35. Tangphao O, Chalon S, Coulston AM, Moreno H, Chan JR, Cooke JP, Hoffman BB, Blaschke TF. L-arginine and nitric oxide-related compounds in plasma: comparison of normal and arginine-free diets in a 24-h crossover study. Vasc Med. 1999; 4(1):27-32. PMID: 10355867.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  36. Lin RZ, Chen J, Hu ZW, Hoffman BB. Phosphorylation of the cAMP response element-binding protein and activation of transcription by alpha1 adrenergic receptors. J Biol Chem. 1998 Nov 06; 273(45):30033-8. PMID: 9792725.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  37. Moreno H, Chalon S, Urae A, Tangphao O, Abiose AK, Hoffman BB, Blaschke TF. Endothelial dysfunction in human hand veins is rapidly reversible after smoking cessation. Am J Physiol. 1998 09; 275(3):H1040-5. PMID: 9724311.
    Citations: 7     Fields:    Translation:Humans
  38. Hu ZW, Shi XY, Hoffman BB. Doxazosin inhibits proliferation and migration of human vascular smooth-muscle cells independent of alpha1-adrenergic receptor antagonism. J Cardiovasc Pharmacol. 1998 Jun; 31(6):833-9. PMID: 9641467.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  39. Lin RZ, Hu ZW, Chin JH, Hoffman BB. Heat shock activates c-Src tyrosine kinases and phosphatidylinositol 3-kinase in NIH3T3 fibroblasts. J Biol Chem. 1997 Dec 05; 272(49):31196-202. PMID: 9388274.
    Citations: 15     Fields:    Translation:AnimalsCells
  40. Abiose AK, Grossmann M, Tangphao O, Hoffman BB, Blaschke TF. Chloroquine-induced venodilation in human hand veins. Clin Pharmacol Ther. 1997 Jun; 61(6):677-83. PMID: 9209251.
    Citations: 3     Fields:    Translation:Humans
  41. Grossmann M, Abiose A, Tangphao O, Blaschke TF, Hoffman BB. Morphine-induced venodilation in humans. Clin Pharmacol Ther. 1996 Nov; 60(5):554-60. PMID: 8941028.
    Citations: 9     Fields:    Translation:Humans
  42. Hu ZW, Shi XY, Hoffman BB. Insulin and insulin-like growth factor I differentially induce alpha1-adrenergic receptor subtype expression in rat vascular smooth muscle cells. J Clin Invest. 1996 Oct 15; 98(8):1826-34. PMID: 8878434; PMCID: PMC507622.
    Citations: 6     Fields:    Translation:AnimalsCells
  43. Chin JH, Okazaki M, Frazier JS, Hu ZW, Hoffman BB. Impaired cAMP-mediated gene expression and decreased cAMP response element binding protein in senescent cells. Am J Physiol. 1996 Jul; 271(1 Pt 1):C362-71. PMID: 8760066.
    Citations: 6     Fields:    Translation:HumansCells
  44. Miller JW, Hu ZW, Okazaki M, Fujinaga M, Hoffman BB. Expression of alpha 1 adrenergic receptor subtype mRNAs in the rat cardiovascular system with aging. Mech Ageing Dev. 1996 Jun 07; 87(2):75-89. PMID: 8783191.
    Citations: 2     Fields:    Translation:Animals
  45. Chin JH, Okazaki M, Hu ZW, Miller JW, Hoffman BB. Activation of heat shock protein (hsp)70 and proto-oncogene expression by alpha1 adrenergic agonist in rat aorta with age. J Clin Invest. 1996 May 15; 97(10):2316-23. PMID: 8636412; PMCID: PMC507312.
    Citations: 7     Fields:    Translation:Animals
  46. Thomas JM, Hoffman BB. Isoform-specific sensitization of adenylyl cyclase activity by prior activation of inhibitory receptors: role of beta gamma subunits in transducing enhanced activity of the type VI isoform. Mol Pharmacol. 1996 May; 49(5):907-14. PMID: 8622641.
    Citations: 11     Fields:    Translation:HumansCells
  47. Hu ZW, Shi XY, Lin RZ, Hoffman BB. Alpha1 adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular smooth muscle cells. Role in mitogenesis. J Biol Chem. 1996 Apr 12; 271(15):8977-82. PMID: 8621543.
    Citations: 12     Fields:    Translation:HumansCells
  48. Smith ER, Kacker SR, Raskin A, Yun PT, Davidson JM, Hoffman BB, Clark JT. Central propranolol and pindolol, but not atenolol nor metoprolol, inhibit sexual behavior in male rats. Physiol Behav. 1996 Feb; 59(2):241-6. PMID: 8838601.
    Citations:    Fields:    Translation:Animals
  49. Chin JH, Hiremath AN, Hoffman BB. cAMP signaling mechanisms with aging in rats. Mech Ageing Dev. 1996 Jan 05; 86(1):11-26. PMID: 8866733.
    Citations: 4     Fields:    Translation:AnimalsCells
  50. Okazaki M, Hu ZW, Fujinaga M, Hoffman BB. Alpha 1 adrenergic receptor activation of proto-oncogene expression in arterial smooth muscle: regulation by nitric oxide and vascular injury. Recept Signal Transduct. 1996; 6(3-4):165-78. PMID: 9259051.
    Citations:    Fields:    Translation:Animals
  51. Smith ER, Cetrulo EJ, Donahue JP, Sparrow H, Davidson JM, Hoffman BB, Clark JT. The inhibitory effects of propranolol on genital reflexes in male rats. Pharmacol Biochem Behav. 1995 Nov; 52(3):541-6. PMID: 8545471.
    Citations: 1     Fields:    Translation:Animals
  52. Fujinaga M, Hu ZW, Okazaki M, Baden JM, Hoffman BB. Expression of mRNA for alpha1-adrenoceptor subtypes at the beginning of neurulation in rat embryos. Toxicol In Vitro. 1995 Oct; 9(5):601-6. PMID: 20650135.
    Citations:    Fields:    
  53. Thomas JM, Frazier JS, Hu ZW, Hoffman BB. Phosphorylation of cyclic AMP response element-binding protein and induction of c-fos gene expression on withdrawal from chronic treatment with carbachol in NG108-15 cells. Mol Pharmacol. 1995 Oct; 48(4):593-600. PMID: 7476883.
    Citations: 1     Fields:    Translation:AnimalsCells
  54. Bedarida G, Bushell E, Blaschke TF, Hoffman BB. H1- and H2-histamine receptor-mediated vasodilation varies with aging in humans. Clin Pharmacol Ther. 1995 Jul; 58(1):73-80. PMID: 7628185.
    Citations: 2     Fields:    Translation:Humans
  55. Smith ER, Stoker D, Kueny T, Davidson JM, Hoffman BB, Clark JT. The inhibition of sexual behavior in male rats by propranolol is stereoselective. Pharmacol Biochem Behav. 1995 Jun-Jul; 51(2-3):439-42. PMID: 7667366.
    Citations:    Fields:    Translation:Animals
  56. Shilo L, Chin JH, Azhar S, Hoffman BB. Prolonged infusion of epinephrine down-regulates expression of the fatty acid synthase gene in adipocytes. Endocrine. 1995 Jun; 3(6):439-44. PMID: 21153248.
    Citations:    Fields:    
  57. Bowersox SS, Miljanich GP, Sugiura Y, Li C, Nadasdi L, Hoffman BB, Ramachandran J, Ko CP. Differential blockade of voltage-sensitive calcium channels at the mouse neuromuscular junction by novel omega-conopeptides and omega-agatoxin-IVA. J Pharmacol Exp Ther. 1995 Apr; 273(1):248-56. PMID: 7714772.
    Citations: 15     Fields:    Translation:AnimalsCells
  58. Hu ZW, Shi XY, Okazaki M, Hoffman BB. Angiotensin II induces transcription and expression of alpha 1-adrenergic receptors in vascular smooth muscle cells. Am J Physiol. 1995 Mar; 268(3 Pt 2):H1006-14. PMID: 7900855.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  59. Fujinaga M, Hoffman BB, Baden JM. Axial rotation in rat embryos: morphological analysis and microsurgical study on the role of the allantois. Teratology. 1995 Feb; 51(2):94-106. PMID: 7660327.
    Citations: 2     Fields:    Translation:Animals
  60. Ford GA, Dachman WD, Blaschke TF, Hoffman BB. Effect of aging on beta 2-adrenergic receptor-stimulated flux of K+, PO4, FFA, and glycerol in human forearms. J Appl Physiol (1985). 1995 Jan; 78(1):172-8. PMID: 7713808.
    Citations: 8     Fields:    Translation:HumansCTClinical Trials
  61. Okazaki M, Hu ZW, Fujinaga M, Hoffman BB. Alpha 1 adrenergic receptor-induced c-fos gene expression in rat aorta and cultured vascular smooth muscle cells. J Clin Invest. 1994 Jul; 94(1):210-8. PMID: 8040263; PMCID: PMC296299.
    Citations: 5     Fields:    Translation:AnimalsCells
  62. Shilo L, Chin JH, Hoffman BB. Impaired beta-adrenergic receptor-mediated regulation of gene expression in adipocytes from older rats. Am J Physiol. 1994 Apr; 266(4 Pt 1):E659-65. PMID: 8178988.
    Citations: 1     Fields:    Translation:AnimalsCells
  63. Fujinaga M, Hoffman BB, Baden JM. Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos. Dev Biol. 1994 Apr; 162(2):558-67. PMID: 8150214.
    Citations: 1     Fields:    Translation:AnimalsCells
  64. Dachman WD, Bedarida G, Blaschke TF, Hoffman BB. Histamine-induced venodilation in human beings involves both H1 and H2 receptor subtypes. J Allergy Clin Immunol. 1994 Mar; 93(3):606-14. PMID: 8151062.
    Citations: 5     Fields:    Translation:Humans
  65. Bedarida GV, Kim D, Blaschke TF, Hoffman BB. Characterization of an inhibitor of nitric oxide synthase in human-hand veins. Horm Metab Res. 1994 Feb; 26(2):109-12. PMID: 7515369.
    Citations: 3     Fields:    Translation:Humans
  66. Hu ZW, Miller JW, Hoffman BB. Induction of enhanced release of endothelium-derived relaxing factor after prolonged exposure to alpha-adrenergic agonists: role in desensitization of smooth muscle contraction. J Cardiovasc Pharmacol. 1994 Feb; 23(2):337-43. PMID: 7511767.
    Citations: 4     Fields:    Translation:AnimalsCells
  67. Sakaue M, Hoffman BB. Effects of cell density and conditioned medium on alpha 2A adrenergic receptor density and messenger RNA abundance in HT-29 cells. Life Sci. 1994; 54(23):1785-91. PMID: 8196492.
    Citations:    Fields:    Translation:HumansCells
  68. Shilo L, Sakaue M, Thomas JM, Philip M, Hoffman BB. Enhanced transcription of the human alpha 2A-adrenergic receptor gene by cAMP: evidence for multiple cAMP responsive sequences in the promoter region of this gene. Cell Signal. 1994 Jan; 6(1):73-82. PMID: 8011430.
    Citations: 2     Fields:    Translation:HumansCells
  69. Bedarida G, Kim D, Blaschke TF, Hoffman BB. Venodilation in Raynaud's disease. Lancet. 1993 Dec 11; 342(8885):1451-4. PMID: 7902481.
    Citations: 10     Fields:    Translation:Humans
  70. Hu ZW, Hoffman BB. Cycloheximide induces the alpha 1B adrenergic receptor gene by activation of transcription in DDT1 MF-2 smooth muscle cells. Mol Pharmacol. 1993 Dec; 44(6):1105-12. PMID: 8264546.
    Citations: 4     Fields:    Translation:AnimalsCells
  71. Bedarida GV, Bushell E, Haefeli WE, Blaschke TF, Hoffman BB. Responsiveness to bradykinin in veins of hypercholesterolemic humans. Circulation. 1993 Dec; 88(6):2754-61. PMID: 8252688.
    Citations: 5     Fields:    Translation:Humans
  72. Valentino K, Newcomb R, Gadbois T, Singh T, Bowersox S, Bitner S, Justice A, Yamashiro D, Hoffman BB, Ciaranello R, et al. A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7894-7. PMID: 8102803; PMCID: PMC47249.
    Citations: 31     Fields:    Translation:AnimalsCells
  73. Ford GA, Blaschke TF, Wiswell R, Hoffman BB. Effect of aging on changes in plasma potassium during exercise. J Gerontol. 1993 Jul; 48(4):M140-5. PMID: 8315226.
    Citations: 1     Fields:    Translation:Humans
  74. Deisher TA, Narita H, Zera P, Ginsburg R, Bristow MR, Billingham ME, Fowler MB, Hoffman BB. Protective effect of clentiazem against epinephrine-induced cardiac injury in rats. J Pharmacol Exp Ther. 1993 Jul; 266(1):262-9. PMID: 8392553.
    Citations:    Fields:    Translation:Animals
  75. Haefeli WE, Srivastava N, Kelsey KT, Wiencke JK, Hoffman BB, Blaschke TF. Glutathione S-transferase mu polymorphism does not explain variation in nitroglycerin responsiveness. Clin Pharmacol Ther. 1993 Apr; 53(4):463-8. PMID: 8477563.
    Citations: 2     Fields:    Translation:Humans
  76. Morrissette DL, Skinner MH, Hoffman BB, Levine RE, Davidson JM. Effects of antihypertensive drugs atenolol and nifedipine on sexual function in older men: a placebo-controlled, crossover study. Arch Sex Behav. 1993 Apr; 22(2):99-109. PMID: 8476337.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  77. Hu ZW, Shi XY, Sakaue M, Hoffman BB. Prolonged activation of protein kinase C induces transcription and expression of the alpha 1B adrenergic receptor gene in DDT1 MF-2 cells. J Biol Chem. 1993 Feb 15; 268(5):3610-5. PMID: 8381435.
    Citations: 4     Fields:    Translation:AnimalsCells
  78. Swislocki AL, Vestal RE, Reaven GM, Hoffman BB. Acute metabolic effects of clonidine and adenosine in man. Horm Metab Res. 1993 Feb; 25(2):90-5. PMID: 8458615.
    Citations:    Fields:    Translation:Humans
  79. Haefeli WE, Srivastava N, Kongpatanakul S, Blaschke TF, Hoffman BB. Lack of role of endothelium-derived relaxing factor in effects of alpha-adrenergic agonists in cutaneous veins in humans. Am J Physiol. 1993 Feb; 264(2 Pt 2):H364-9. PMID: 8095374.
    Citations: 3     Fields:    Translation:Humans
  80. Haefeli WE, Bargetzi MJ, Starnes HF, Blaschke TF, Hoffman BB. Evidence for activation of the sympathetic nervous system by recombinant human interleukin-1 beta in humans. J Immunother Emphasis Tumor Immunol. 1993 Feb; 13(2):136-40. PMID: 8318499.
    Citations: 8     Fields:    Translation:Humans
  81. Dachman WD, Ford GA, Blaschke TF, Hoffman BB. Mechanism of bradykinin-induced venodilation in humans. J Cardiovasc Pharmacol. 1993 Feb; 21(2):241-8. PMID: 7679158.
    Citations: 9     Fields:    Translation:Humans
  82. Thomas JM, Hoffman BB. Buprenorphine prevents and reverses the expression of chronic etorphine-induced sensitization of adenylyl cyclase in SK-N-SH human neuroblastoma cells. J Pharmacol Exp Ther. 1993 Jan; 264(1):368-74. PMID: 8380866.
    Citations: 1     Fields:    Translation:HumansCells
  83. Haefeli WE, Gumbleton M, Benet LZ, Hoffman BB, Blaschke TF. Comparison of vasodilatory responses to nitroglycerin and its dinitrate metabolites in human veins. Clin Pharmacol Ther. 1992 Dec; 52(6):590-6. PMID: 1458768.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  84. Vincent J, Kongpatanakul S, Blaschke TF, Hoffman BB. Desensitization of nitrate-induced venodilation: reversal with oral N-acetylcysteine in humans. J Cardiovasc Pharmacol. 1992 Dec; 20(6):907-12. PMID: 1282593.
    Citations: 1     Fields:    Translation:Humans
  85. Hu Z, Azhar S, Hoffman BB. Prolonged activation of alpha 1 adrenoceptors induces down-regulation of protein kinase C in vascular smooth muscle. J Cardiovasc Pharmacol. 1992 Dec; 20(6):982-9. PMID: 1282603.
    Citations: 4     Fields:    Translation:AnimalsCells
  86. Vincent J, Dachman W, Blaschke TF, Hoffman BB. Pharmacological tolerance to alpha 1-adrenergic receptor antagonism mediated by terazosin in humans. J Clin Invest. 1992 Nov; 90(5):1763-8. PMID: 1358918; PMCID: PMC443234.
    Citations: 5     Fields:    Translation:Humans
  87. Thomas JM, Meier-Davis SR, Hoffman BB. Prolonged activation of inhibitory somatostatin receptors increases adenylate cyclase activity in wild-type and Gs alpha-deficient (cyc-) S49 mouse lymphoma cells. Cell Signal. 1992 Sep; 4(5):571-81. PMID: 1329904.
    Citations: 2     Fields:    Translation:AnimalsCells
  88. Dachman WD, Ford GA, Hoffman BB, Blaschke TF. Bradykinin-induced venodilation is not impaired with aging in humans. J Gerontol. 1992 Sep; 47(5):M166-70. PMID: 1512432.
    Citations: 4     Fields:    Translation:Humans
  89. Thomas JM, Hoffman BB. Adaptive increase in adenylyl cyclase activity in NG108-15 and S49 cells induced by chronic treatment with inhibitory drugs is not due to a decrease in cyclic AMP concentrations. Cell Signal. 1992 Jul; 4(4):417-28. PMID: 1329899.
    Citations:    Fields:    Translation:Cells
  90. Skinner MH, Futterman A, Morrissette D, Thompson LW, Hoffman BB, Blaschke TF. Atenolol compared with nifedipine: effect on cognitive function and mood in elderly hypertensive patients. Ann Intern Med. 1992 Apr 15; 116(8):615-23. PMID: 1546860.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  91. Fujinaga M, Maze M, Hoffman BB, Baden JM. Activation of alpha-1 adrenergic receptors modulates the control of left/right sidedness in rat embryos. Dev Biol. 1992 Apr; 150(2):419-21. PMID: 1348038.
    Citations:    Fields:    Translation:AnimalsCells
  92. Costa EM, Hoffman BB, Loew GH. Assessment of delta-opioid receptor activation by a series of peptides in cultured cells. Int J Pept Protein Res. 1992 Mar; 39(3):245-9. PMID: 1328097.
    Citations:    Fields:    Translation:Cells
  93. Vincent J, Blaschke TF, Hoffman BB. Desensitization of beta-adrenoceptor- and prostaglandin E1 receptor-mediated human vascular smooth muscle relaxation. J Cardiovasc Pharmacol. 1992 Mar; 19(3):447-52. PMID: 1378128.
    Citations: 2     Fields:    Translation:Humans
  94. Eichler HG, Blaschke TF, Kraemer FB, Ford GA, Blöchl-Daum B, Hoffman BB. Responsiveness of superficial hand veins to alpha-adrenoceptor agonists in insulin-dependent diabetic patients. Clin Sci (Lond). 1992 Feb; 82(2):163-8. PMID: 1347259.
    Citations: 8     Fields:    Translation:Humans
  95. Hu ZW, Honda K, Murad F, Hoffman BB. Prolonged exposure to catecholamines enhances sensitivity of smooth muscle relaxation induced by sodium nitroprusside and atriopeptin. J Pharmacol Exp Ther. 1992 Feb; 260(2):756-61. PMID: 1346644.
    Citations: 4     Fields:    Translation:Animals
  96. Chin JH, Azhar S, Hoffman BB. Inactivation of endothelial derived relaxing factor by oxidized lipoproteins. J Clin Invest. 1992 Jan; 89(1):10-8. PMID: 1309534; PMCID: PMC442813.
    Citations: 52     Fields:    Translation:AnimalsCells
  97. Bowersox SS, Singh T, Nadasdi L, Zukowska-Grojec Z, Valentino K, Hoffman BB. Cardiovascular effects of omega-conopeptides in conscious rats: mechanisms of action. J Cardiovasc Pharmacol. 1992; 20(5):756-64. PMID: 1280738.
    Citations: 14     Fields:    Translation:AnimalsCells
  98. Ford GA, Hoffman BB, Vestal RE, Blaschke TF. Age-related changes in adenosine and beta-adrenoceptor responsiveness of vascular smooth muscle in man. Br J Clin Pharmacol. 1992 Jan; 33(1):83-7. PMID: 1311596; PMCID: PMC1381203.
    Citations: 7     Fields:    Translation:Humans
  99. Vincent J, Blaschke TF, Hoffman BB. Vascular reactivity to phenylephrine and angiotensin II: comparison of direct venous and systemic vascular responses. Clin Pharmacol Ther. 1992 Jan; 51(1):68-75. PMID: 1732078.
    Citations: 3     Fields:    Translation:Humans
  100. Ford GA, Hoffman BB, Blaschke TF. Beta adrenergically mediated cardiac chronotropic and vascular smooth muscle responses during propranolol therapy and withdrawal in young and elderly persons. J Gerontol. 1992 Jan; 47(1):M22-6. PMID: 1730849.
    Citations: 2     Fields:    Translation:Humans
  101. Hoffman BB. Adrenergic pharmacology in rats harboring pheochromocytoma. Hypertension. 1991 Nov; 18(5 Suppl):III35-9. PMID: 1657774.
    Citations: 2     Fields:    Translation:Animals
  102. Sakaue M, Hoffman BB. Glucocorticoids induce transcription and expression of the alpha 1B adrenergic receptor gene in DTT1 MF-2 smooth muscle cells. J Clin Invest. 1991 Aug; 88(2):385-9. PMID: 1650792; PMCID: PMC295342.
    Citations: 18     Fields:    Translation:AnimalsCells
  103. Ford GA, Katzir D, Blaschke TF, Hoffman BB. Responsiveness of peripheral veins to vasodilators and the effect of nifedipine on alpha-adrenergic responsiveness in hypertension. Clin Pharmacol Ther. 1991 Aug; 50(2):192-8. PMID: 1651200.
    Citations: 1     Fields:    Translation:Humans
  104. Hiremath AN, Hu ZW, Hoffman BB. Desensitization of alpha-adrenergic receptor-mediated smooth muscle contraction: role of the endothelium. J Cardiovasc Pharmacol. 1991 Jul; 18(1):151-7. PMID: 1719284.
    Citations: 2     Fields:    Translation:Animals
  105. Twersky J, Hoffman BB, Reaven GM. Age-associated differences in beta adrenergic-stimulated lipolysis in adipocytes from Sprague-Dawley and Fischer 344 rats. J Gerontol. 1991 Jul; 46(4):B125-9. PMID: 2071826.
    Citations:    Fields:    Translation:AnimalsCells
  106. Sakaue M, Hoffman BB. cAMP regulates transcription of the alpha 2A adrenergic receptor gene in HT-29 cells. J Biol Chem. 1991 Mar 25; 266(9):5743-9. PMID: 1848558.
    Citations: 10     Fields:    Translation:HumansCells
  107. Chin JH, Hoffman BB. Beta-adrenergic responsiveness in cultured vascular smooth muscle cells and fibroblasts: effect of age. Mech Ageing Dev. 1991 Mar; 57(3):259-73. PMID: 1647473.
    Citations: 1     Fields:    Translation:AnimalsCells
  108. Sheu WH, Swislocki AL, Hoffman BB, Reaven GM, Chen YD. Effect of prazosin treatment on HDL kinetics in patients with hypertension. Am J Hypertens. 1990 Oct; 3(10):761-8. PMID: 2121164.
    Citations:    Fields:    Translation:Humans
  109. Eichler HG, Blaschke TF, Hoffman BB. Decreased responsiveness of superficial hand veins to phenylephrine in black normotensive males. J Cardiovasc Pharmacol. 1990 Aug; 16(2):177-81. PMID: 1697371.
    Citations: 2     Fields:    Translation:Humans
  110. Reaven GM, Ho H, Hoffman BB. Effects of a fructose-enriched diet on plasma insulin and triglyceride concentration in SHR and WKY rats. Horm Metab Res. 1990 Jul; 22(7):363-5. PMID: 2205554.
    Citations: 3     Fields:    Translation:Animals
  111. Chin JH, Hoffman BB. Age-related deficit in beta receptor stimulation of cAMP binding in blood vessels. Mech Ageing Dev. 1990 Apr 09; 53(2):111-25. PMID: 2160570.
    Citations: 1     Fields:    Translation:Animals
  112. Thomas JM, Vagelos R, Hoffman BB. Decreased cyclic AMP degradation in NG 108-15 neuroblastoma X glioma hybrid cells and S49 lymphoma cells chronically treated with drugs that inhibit adenylate cyclase. J Neurochem. 1990 Feb; 54(2):402-10. PMID: 1688917.
    Citations: 1     Fields:    Translation:AnimalsCells
  113. Thomas JM, Hoffman BB. Activation of muscarinic cholinergic receptors in mouse neuroblastoma x rat glioma hybrid cells: rapid induction of enhanced capacity of prostaglandin E1 receptors to stimulate cyclic AMP accumulation. J Pharmacol Exp Ther. 1990 Feb; 252(2):616-22. PMID: 2156056.
    Citations:    Fields:    Translation:AnimalsCells
  114. Hu ZW, Billingham M, Tuck M, Hoffman BB. Captopril improves hypertension and cardiomyopathy in rats with pheochromocytoma. Hypertension. 1990 Feb; 15(2):210-5. PMID: 2154406.
    Citations: 1     Fields:    Translation:Animals
  115. Ford GA, Hoffman BB, Blaschke TF. Effect of temazepam on blood pressure regulation in healthy elderly subjects. Br J Clin Pharmacol. 1990 Jan; 29(1):61-7. PMID: 1967533; PMCID: PMC1380062.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  116. Reaven GM, Hoffman BB. Hypertension as a disease of carbohydrate and lipoprotein metabolism. Am J Med. 1989 Dec 08; 87(6A):2S-6S. PMID: 2688409.
    Citations: 9     Fields:    Translation:HumansCells
  117. Hiremath AN, Hoffman BB, Blaschke TF. Responsiveness of peripheral veins to transdermal and sublingual nitroglycerin in healthy male volunteers. J Cardiovasc Pharmacol. 1989 Oct; 14(4):534-41. PMID: 2478766.
    Citations: 3     Fields:    Translation:Humans
  118. Reaven GM, Chang H, Hoffman BB, Azhar S. Resistance to insulin-stimulated glucose uptake in adipocytes isolated from spontaneously hypertensive rats. Diabetes. 1989 Sep; 38(9):1155-60. PMID: 2670644.
    Citations: 13     Fields:    Translation:AnimalsCells
  119. Munoz E, Tsujimoto G, Tsujimoto A, Azhar S, Hoffman BB. Desensitization of alpha 1 adrenoceptor-stimulated glycogen phosphorylase activity in vascular smooth muscle. J Cardiovasc Pharmacol. 1989 Aug; 14(2):278-84. PMID: 2476602.
    Citations:    Fields:    Translation:Animals
  120. Deisher TA, Mankani S, Hoffman BB. Role of cyclic AMP-dependent protein kinase in the diminished beta adrenergic responsiveness of vascular smooth muscle with increasing age. J Pharmacol Exp Ther. 1989 Jun; 249(3):812-9. PMID: 2543812.
    Citations: 8     Fields:    Translation:Animals
  121. Swislocki AL, Hoffman BB, Reaven GM. Insulin resistance, glucose intolerance and hyperinsulinemia in patients with hypertension. Am J Hypertens. 1989 Jun; 2(6 Pt 1):419-23. PMID: 2667570.
    Citations: 32     Fields:    Translation:Humans
  122. Hoffman BB, Prokocimer P, Thomas JM, Vagelos R, Chang H, Reaven GM. Cellular tolerance to adenosine receptor-mediated inhibition of lipolysis: altered adenosine 3',5'-monophosphate metabolism and protein kinase activation. Endocrinology. 1989 May; 124(5):2434-42. PMID: 2539980.
    Citations: 5     Fields:    Translation:AnimalsCells
  123. Reaven GM, Chang H, Hoffman BB. Impaired insulin-mediated inhibition of lipolysis and glucose transport with aging. Horm Metab Res. 1989 Apr; 21(4):168-71. PMID: 2666294.
    Citations: 1     Fields:    Translation:AnimalsCells
  124. Eichler HG, Eichler I, Lewiston N, Blaschke TF, Hoffman BB. Responsiveness of superficial hand veins to adrenergic stimuli in patients with cystic fibrosis. Clin Sci (Lond). 1989 Mar; 76(3):283-7. PMID: 2924520.
    Citations: 1     Fields:    Translation:Humans
  125. Tsujimoto G, Hashimoto K, Hoffman BB. Pharmacokinetic and pharmacodynamic principles of drug therapy in old age. Part 2. Int J Clin Pharmacol Ther Toxicol. 1989 Mar; 27(3):102-16. PMID: 2656543.
    Citations: 4     Fields:    Translation:Humans
  126. Swislocki AL, Hoffman BB, Sheu WH, Chen YD, Reaven GM. Effect of prazosin treatment on carbohydrate and lipoprotein metabolism in patients with hypertension. Am J Med. 1989 Jan 23; 86(1B):14-8. PMID: 2643861.
    Citations: 6     Fields:    Translation:Humans
  127. Thomas JM, Hoffman BB. Chronic somatostatin treatment induces enhanced forskolin-stimulated cAMP accumulation in wild-type S49 mouse lymphoma cells but not in protein kinase-deficient mutants. Mol Pharmacol. 1989 Jan; 35(1):116-24. PMID: 2563303.
    Citations: 1     Fields:    Translation:AnimalsCells
  128. Eichler HG, Ford GA, Blaschke TF, Swislocki A, Hoffman BB. Responsiveness of superficial hand veins to phenylephrine in essential hypertension. Alpha adrenergic blockade during prazosin therapy. J Clin Invest. 1989 Jan; 83(1):108-12. PMID: 2562959; PMCID: PMC303650.
    Citations: 12     Fields:    Translation:Humans
  129. Hiremath AN, Pershe RA, Hoffman BB, Blaschke TF. Comparison of age-related changes in prostaglandin E1 and beta-adrenergic responsiveness of vascular smooth muscle in adult males. J Gerontol. 1989 Jan; 44(1):M13-7. PMID: 2536054.
    Citations: 8     Fields:    Translation:Humans
  130. Tsujimoto G, Hashimoto K, Hoffman BB. Pharmacokinetic and pharmacodynamic principles of drug therapy in old age. Part 1. Int J Clin Pharmacol Ther Toxicol. 1989 Jan; 27(1):13-26. PMID: 2663734.
    Citations: 10     Fields:    Translation:Humans
  131. Ford GA, Eichler HG, Hoffman BB, Blaschke TF. Venous responsiveness to atrial natriuretic factor in man. Br J Clin Pharmacol. 1988 Dec; 26(6):797-9. PMID: 2977285; PMCID: PMC1386598.
    Citations: 2     Fields:    Translation:Humans
  132. Bristow MR, Minobe W, Rasmussen R, Hershberger RE, Hoffman BB. Alpha-1 adrenergic receptors in the nonfailing and failing human heart. J Pharmacol Exp Ther. 1988 Dec; 247(3):1039-45. PMID: 2849656.
    Citations: 25     Fields:    Translation:Humans
  133. Reaven GM, Ho H, Hoffman BB. Attenuation of fructose-induced hypertension in rats by exercise training. Hypertension. 1988 Aug; 12(2):129-32. PMID: 3410522.
    Citations: 14     Fields:    Translation:Animals
  134. Prokocimer PG, Maze M, Vickery RG, Hoffman BB. Mechanism for desensitization of beta-adrenergic receptor-stimulated lipolysis in adipocytes from rats harboring pheochromocytoma. Endocrinology. 1988 Jul; 123(1):528-33. PMID: 2838264.
    Citations: 1     Fields:    Translation:AnimalsCells
  135. Prokocimer PG, Maze M, Vickery RG, Kraemer FB, Gandjei R, Hoffman BB. Mechanism of halothane-induced inhibition of isoproterenol-stimulated lipolysis in isolated rat adipocytes. Mol Pharmacol. 1988 Mar; 33(3):338-43. PMID: 3352597.
    Citations: 2     Fields:    Translation:AnimalsCells
  136. Reaven GM, Hoffman BB. Abnormalities of carbohydrate metabolism may play a role in the etiology and clinical course of hypertension. Trends Pharmacol Sci. 1988 Mar; 9(3):78-9. PMID: 3072736.
    Citations: 4     Fields:    Translation:Humans
  137. Reaven GM, Chang H, Ho H, Jeng CY, Hoffman BB. Lowering of plasma glucose in diabetic rats by antilipolytic agents. Am J Physiol. 1988 Jan; 254(1 Pt 1):E23-30. PMID: 2962514.
    Citations: 8     Fields:    Translation:AnimalsCells
  138. Reaven GM, Chang H, Hoffman BB. Additive hypoglycemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozocin-induced diabetes. Diabetes. 1988 Jan; 37(1):28-32. PMID: 3275556.
    Citations: 10     Fields:    Translation:AnimalsCells
  139. Rosenbaum JS, Billingham ME, Ginsburg R, Tsujimoto G, Lurie KG, Hoffman BB. Cardiomyopathy in a rat model of pheochromocytoma. Morphological and functional alterations. Am J Cardiovasc Pathol. 1988; 1(3):389-99. PMID: 3207483.
    Citations: 8     Fields:    Translation:Animals
  140. Rosenbaum JS, Azhar S, Hoffman BB. Alpha 1 adrenergic receptor mediated polyphosphoinositide breakdown in DDT1-MF2 cells. Lack of evidence of desensitization after prolonged exposure to epinephrine. Biochem Pharmacol. 1987 Dec 15; 36(24):4335-40. PMID: 2825723.
    Citations: 3     Fields:    Translation:Cells
  141. Oates J, Lowenthal DT, Kane RL, Hoffman BB, Beck JC. The concept of geriatric clinical pharmacology. Panel II: Assessing progress and value of training programs. Clin Pharmacol Ther. 1987 Dec; 42(6):702-4. PMID: 3690952.
    Citations:    Fields:    Translation:Humans
  142. Hwang IS, Ho H, Hoffman BB, Reaven GM. Fructose-induced insulin resistance and hypertension in rats. Hypertension. 1987 Nov; 10(5):512-6. PMID: 3311990.
    Citations: 134     Fields:    Translation:Animals
  143. Hoffman BB. Observations in New England Deaconess Hospital rats harboring pheochromocytoma. Clin Invest Med. 1987 Nov; 10(6):555-60. PMID: 2831003.
    Citations: 1     Fields:    Translation:Animals
  144. Eichler HG, Hiremath A, Katzir D, Blaschke TF, Hoffman BB. Absence of age-related changes in venous responsiveness to nitroglycerin in vivo in humans. Clin Pharmacol Ther. 1987 Nov; 42(5):521-4. PMID: 3119271.
    Citations: 16     Fields:    Translation:Humans
  145. Reaven GM, Hoffman BB. A role for insulin in the aetiology and course of hypertension? Lancet. 1987 Aug 22; 2(8556):435-7. PMID: 2887735.
    Citations: 33     Fields:    Translation:Humans
  146. Hoffman BB, Chang H, Reaven GM. Stimulation and inhibition of lipolysis in isolated rat adipocytes: evidence for age-related changes in responses to forskolin and PGE1. Horm Metab Res. 1987 Aug; 19(8):358-60. PMID: 2822560.
    Citations: 1     Fields:    Translation:AnimalsCells
  147. Tsujimoto G, Minegishi A, Ishizaki T, Hoffman BB, Hashimoto K. Characterization of vasopressor response to sympathetic stimulation in the pithed rat: differential regulation of neuronally stimulated and blood-borne catecholamine-stimulated pressor responses in rats harboring pheochromocytoma. J Pharmacol Exp Ther. 1987 Aug; 242(2):637-45. PMID: 2886647.
    Citations:    Fields:    Translation:Animals
  148. Tsujimoto G, Honda K, Hoffman BB, Hashimoto K. Desensitization of postjunctional alpha 1- and alpha 2-adrenergic receptor-mediated vasopressor responses in rat harboring pheochromocytoma. Circ Res. 1987 Jul; 61(1):86-98. PMID: 3038368.
    Citations: 6     Fields:    Translation:AnimalsCells
  149. Khan MM, Marr-Leisy D, Rosenkranz R, Hoffman BB, Verlander MS, Goodman M, Melmon KL. In vitro pharmacologic activity of congener derivatives and model conjugates of propranolol and practolol. Biochem Pharmacol. 1987 Jul 01; 36(13):2175-82. PMID: 3038116.
    Citations: 1     Fields:    Translation:AnimalsCells
  150. Prokocimer PG, Maze M, Hoffman BB. Role of the sympathetic nervous system in the maintenance of hypertension in rats harboring pheochromocytoma. J Pharmacol Exp Ther. 1987 Jun; 241(3):870-4. PMID: 3598906.
    Citations:    Fields:    Translation:Animals
  151. Rosenbaum JS, Ginsburg R, Billingham ME, Hoffman BB. Effects of adrenergic receptor antagonists on cardiac morphological and functional alterations in rats harboring pheochromocytoma. J Pharmacol Exp Ther. 1987 Apr; 241(1):354-60. PMID: 2883296.
    Citations: 4     Fields:    Translation:Animals
  152. Tsujimoto G, Hashimoto K, Hoffman BB. Effects of thyroid hormone on beta-adrenergic responsiveness of aging cardiovascular systems. Am J Physiol. 1987 Mar; 252(3 Pt 2):H513-20. PMID: 3030139.
    Citations: 2     Fields:    Translation:Animals
  153. Garfinkel D, Hoffman BB. Therapeutic rounds. Digitalis toxicity. Clin Ther. 1987; 9(4):358-9, 434-5. PMID: 3607816.
    Citations:    Fields:    Translation:Humans
  154. Garfinkel D, Glazener F, Hoffman BB. Metronidazole interferes with theophylline measurements. Ann Intern Med. 1987 Jan; 106(1):171. PMID: 3789570.
    Citations:    Fields:    Translation:Humans
  155. Pan HY, Hoffman BB, Pershe RA, Blaschke TF. Decline in beta adrenergic receptor-mediated vascular relaxation with aging in man. J Pharmacol Exp Ther. 1986 Dec; 239(3):802-7. PMID: 3025419.
    Citations: 35     Fields:    Translation:Humans
  156. Hoffman BB, Dall'Aglio E, Hollenbeck C, Chang H, Reaven GM. Suppression of free fatty acids and triglycerides in normal and hypertriglyceridemic rats by the adenosine receptor agonist phenylisopropyladenosine. J Pharmacol Exp Ther. 1986 Dec; 239(3):715-8. PMID: 3795036.
    Citations: 2     Fields:    Translation:AnimalsCells
  157. Tsujimoto G, Lee CH, Hoffman BB. Age-related decrease in beta adrenergic receptor-mediated vascular smooth muscle relaxation. J Pharmacol Exp Ther. 1986 Nov; 239(2):411-5. PMID: 2430092.
    Citations: 16     Fields:    
  158. Thomas JM, Hoffman BB. Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin. Endocrinology. 1986 Sep; 119(3):1305-14. PMID: 2426098.
    Citations: 2     Fields:    Translation:AnimalsCells
  159. Rosenbaum JS, Zera P, Umans VA, Ginsburg R, Hoffman BB. Desensitization of aortic smooth muscle contraction in rats harboring pheochromocytoma. J Pharmacol Exp Ther. 1986 Aug; 238(2):396-400. PMID: 3016236.
    Citations: 3     Fields:    Translation:Animals
  160. Hoffman BB, Chang H, Dall'Aglio E, Reaven GM. Desensitization of adenosine receptor-mediated inhibition of lipolysis. The mechanism involves the development of enhanced cyclic adenosine monophosphate accumulation in tolerant adipocytes. J Clin Invest. 1986 Jul; 78(1):185-90. PMID: 3013937; PMCID: PMC329548.
    Citations: 4     Fields:    Translation:AnimalsCells
  161. Tsujimoto A, Tsujimoto G, Azhar S, Hoffman BB. Altered responsiveness to alpha- and beta-adrenoceptor stimulation in hepatocytes cultured in defined medium. Biochem Pharmacol. 1986 Apr 15; 35(8):1400-4. PMID: 2870718.
    Citations: 4     Fields:    Translation:AnimalsCells
  162. Tsujimoto G, Timmins PV, Hoffman BB. Alpha adrenergic receptors in the rabbit bladder base smooth muscle: alpha-1 adrenergic receptors mediate contractile responses. J Pharmacol Exp Ther. 1986 Feb; 236(2):384-9. PMID: 2868117.
    Citations: 2     Fields:    Translation:Animals
  163. Thomas JM, Hoffman BB. Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin. J Cyclic Nucleotide Protein Phosphor Res. 1986; 11(4):317-25. PMID: 3025278.
    Citations:    Fields:    Translation:Cells
  164. Tsujimoto A, Tsujimoto G, Hoffman BB. Age-related change in adrenergic regulation of glycogen phosphorylase in rat hepatocytes. Mech Ageing Dev. 1986 Jan; 33(2):167-75. PMID: 3007877.
    Citations: 1     Fields:    Translation:AnimalsCells
  165. Maze M, Spiss CK, Tsujimoto G, Hoffman BB. Epinephrine infusion induces hyporesponsiveness of vascular smooth muscle. Life Sci. 1985 Oct 28; 37(17):1571-8. PMID: 2997566.
    Citations: 5     Fields:    Translation:Animals
  166. Lurie KG, Chin JH, Hoffman BB. Decreased membrane fluidity and beta-adrenergic responsiveness in atherosclerotic quail. Am J Physiol. 1985 Aug; 249(2 Pt 2):H380-5. PMID: 2992295.
    Citations: 2     Fields:    Translation:AnimalsCells
  167. Tsujimoto G, Hashimoto K, Hoffman BB. Effects of pheochromocytoma on cardiovascular alpha adrenergic receptor system. Heart Vessels. 1985 Aug; 1(3):152-7. PMID: 3007429.
    Citations: 3     Fields:    Translation:Animals
  168. Lurie KG, Tsujimoto G, Hoffman BB. Desensitization of alpha-1 adrenergic receptor-mediated vascular smooth muscle contraction. J Pharmacol Exp Ther. 1985 Jul; 234(1):147-52. PMID: 2989501.
    Citations: 12     Fields:    Translation:Animals
  169. García-Sáinz JA, Villalobos-Molina R, Corvera S, Huerta-Bahena J, Tsujimoto G, Hoffman BB. Differential effects of adrenergic agonists and phorbol esters on the alpha 1-adrenoceptors of hepatocytes and aorta. Eur J Pharmacol. 1985 Jun 19; 112(3):393-7. PMID: 2862055.
    Citations:    Fields:    Translation:Animals
  170. Reitz AB, Avery MA, Rosenkranz RP, Verlander MS, Melmon KL, Hoffman BB, Akita Y, Castagnoli N, Goodman M. Conjugates of catecholamines. 6. Synthesis and beta-adrenergic activity of N-(hydroxyalkyl)catecholamine derivatives. J Med Chem. 1985 May; 28(5):642-7. PMID: 2859373.
    Citations:    Fields:    Translation:AnimalsCells
  171. Manger WM, Gifford RW, Hoffman BB. Pheochromocytoma: a clinical and experimental overview. Curr Probl Cancer. 1985 May; 9(5):1-89. PMID: 3021396.
    Citations: 9     Fields:    Translation:HumansAnimals
  172. Reitz AB, Sonveaux E, Rosenkranz RP, Verlander MS, Melmon KL, Hoffman BB, Akita Y, Castagnoli N, Goodman M. Conjugates of catecholamines. 5. Synthesis and beta-adrenergic activity of N-(aminoalkyl)norepinephrine derivatives. J Med Chem. 1985 May; 28(5):634-42. PMID: 2859372.
    Citations:    Fields:    Translation:AnimalsCells
  173. Tsujimoto G, Hoffman BB. Desensitization of beta-adrenergic receptor-mediated vascular smooth muscle relaxation. Mol Pharmacol. 1985 Feb; 27(2):210-7. PMID: 2578603.
    Citations: 5     Fields:    Translation:Animals
  174. Hoffman BB, Tsujimoto G. Direct measurement of vascular alpha 1-adrenoceptors. Clin Sci (Lond). 1985; 68 Suppl 10:35s-37s. PMID: 2857616.
    Citations:    Fields:    Translation:AnimalsCells
  175. Spiss CK, Smith CM, Tsujimoto G, Hoffman BB, Maze M. Prolonged hyporesponsiveness of vascular smooth muscle contraction after halothane anesthesia in rabbits. Anesth Analg. 1985 Jan; 64(1):1-6. PMID: 2981487.
    Citations: 5     Fields:    Translation:Animals
  176. Hoffman BB, Chang H, Farahbakhsh ZT, Reaven GM. Age-related decrement in hormone-stimulated lipolysis. Am J Physiol. 1984 Dec; 247(6 Pt 1):E772-7. PMID: 6150643.
    Citations: 5     Fields:    Translation:AnimalsCells
  177. Hoffman BB, Chang H, Farahbakhsh Z, Reaven G. Inhibition of lipolysis by adenosine is potentiated with age. J Clin Invest. 1984 Nov; 74(5):1750-5. PMID: 6094613; PMCID: PMC425354.
    Citations: 14     Fields:    Translation:Animals
  178. Tsujimoto G, Manger WM, Hoffman BB. Desensitization of beta-adrenergic receptors by pheochromocytoma. Endocrinology. 1984 Apr; 114(4):1272-8. PMID: 6323140.
    Citations: 16     Fields:    Translation:AnimalsCells
  179. Tsujimoto G, Bristow MR, Hoffman BB. Identification of alpha 1 adrenergic receptors in rabbit aorta with [125I] BE2254. Life Sci. 1984 Feb 13; 34(7):639-46. PMID: 6321870.
    Citations: 2     Fields:    Translation:AnimalsCells
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