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profileBrian Benjamin Hoffman, M.D.,C.M.

TitleProfessor of Medicine, Emeritus
InstitutionHarvard Medical School
DepartmentEmeritus
AddressV.A. Medical Center - Boston
Maveric (151 MAV)
150 S Huntington Ave
Jamaica Plain MA 02130
Phone857/364-4676
Fax857/364-4424
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01GM057545     (CLARK, DAVID J)Jan 1, 1999 - Jun 30, 2004
NIH/NIGMS
MECHANISMS FOR TOLERANCE TO ACTIONS OF A2 AGONISTS
Role: Co-Principal Investigator

P01HL048743     (MICHEL, THOMAS)Sep 30, 1992 - Mar 31, 2015
NIH/NHLBI
Arterial Dysfunction: Basic and Clinical Mechanisms
Role: Co-Principal Investigator

R01AG009597     (HOFFMAN, BRIAN B)Feb 15, 1991 - Jan 31, 1996
NIH/NIA
MOLECULAR PHARMACOLOGY OF ADRENERGIC RECEPTORS IN AGING
Role: Principal Investigator

R01HL041315     (HOFFMAN, BRIAN B)Jul 1, 1988 - May 31, 2005
NIH/NHLBI
ALPHA 1 ADRENERGIC RESPONSES IN SMOOTH MUSCLE
Role: Principal Investigator

R01AG005676     (HOFFMAN, BRIAN B)Aug 1, 1985 - Jul 31, 1989
NIH/NIA
REGULATION OF LIPOLYSIS WITH AGING
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Abiose AK, Aronow WS, Moreno H, Nair CK, Blaschke TF, Hoffman BB. Increased vascular alpha1-adrenergic sensitivity in patients with renal failure: receiving recombinant erythropoeitin. Am J Ther. 2007 Sep-Oct; 14(5):427-34. PMID: 17890929.
    View in: PubMed
  2. Bosworth HB, Olsen MK, McCant F, Harrelson M, Gentry P, Rose C, Goldstein MK, Hoffman BB, Powers B, Oddone EZ. Hypertension Intervention Nurse Telemedicine Study (HINTS): testing a multifactorial tailored behavioral/educational and a medication management intervention for blood pressure control. Am Heart J. 2007 Jun; 153(6):918-24. PMID: 17540191.
    View in: PubMed
  3. Martins SB, Lai S, Tu S, Shankar R, Hastings SN, Hoffman BB, Dipilla N, Goldstein MK. Offline testing of the ATHENA Hypertension decision support system knowledge base to improve the accuracy of recommendations. AMIA Annu Symp Proc. 2006; 539-43. PMID: 17238399; PMCID: PMC1839611.
  4. Lin ND, Martins SB, Chan AS, Coleman RW, Bosworth HB, Oddone EZ, Shankar RD, Musen MA, Hoffman BB, Goldstein MK. Identifying barriers to hypertension guideline adherence using clinician feedback at the point of care. AMIA Annu Symp Proc. 2006; 494-8. PMID: 17238390; PMCID: PMC1839712.
  5. Goldstein MK, Lavori P, Coleman R, Advani A, Hoffman BB. Improving adherence to guidelines for hypertension drug prescribing: cluster-randomized controlled trial of general versus patient-specific recommendations. Am J Manag Care. 2005 Nov; 11(11):677-85. PMID: 16268751.
    View in: PubMed
  6. Chan AS, Shankar RD, Coleman RW, Matins SB, Hoffman BB, Goldstein MK. Leveraging point-of-care clinician feedback to study barriers to guideline adherence. AMIA Annu Symp Proc. 2005; 915. PMID: 16779202; PMCID: PMC1560728.
  7. Steinman MA, Fischer MA, Shlipak MG, Bosworth HB, Oddone EZ, Hoffman BB, Goldstein MK. Clinician awareness of adherence to hypertension guidelines. Am J Med. 2004 Nov 15; 117(10):747-54. PMID: 15541324.
    View in: PubMed
  8. Goldstein MK, Coleman RW, Tu SW, Shankar RD, O'Connor MJ, Musen MA, Martins SB, Lavori PW, Shlipak MG, Oddone E, Advani AA, Gholami P, Hoffman BB. Translating research into practice: organizational issues in implementing automated decision support for hypertension in three medical centers. J Am Med Inform Assoc. 2004 Sep-Oct; 11(5):368-76. PMID: 15187064; PMCID: PMC516243.
  9. Davies MF, Tsui J, Flannery JA, Li X, DeLorey TM, Hoffman BB. Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology. 2004 Feb; 29(2):229-39. PMID: 14583739.
    View in: PubMed
  10. Chan AS, Coleman RW, Martins SB, Advani A, Musen MA, Bosworth HB, Oddone EZ, Shlipak MG, Hoffman BB, Goldstein MK. Evaluating provider adherence in a trial of a guideline-based decision support system for hypertension. Stud Health Technol Inform. 2004; 107(Pt 1):125-9. PMID: 15360788.
    View in: PubMed
  11. Davies MF, Tsui JY, Flannery JA, Li X, DeLorey TM, Hoffman BB. Augmentation of the noradrenergic system in alpha-2 adrenergic receptor deficient mice: anatomical changes associated with enhanced fear memory. Brain Res. 2003 Oct 03; 986(1-2):157-65. PMID: 12965240.
    View in: PubMed
  12. Chen J, Hoffman BB, Isseroff RR. Beta-adrenergic receptor activation inhibits keratinocyte migration via a cyclic adenosine monophosphate-independent mechanism. J Invest Dermatol. 2002 Dec; 119(6):1261-8. PMID: 12485426.
    View in: PubMed
  13. Hu ZW, Kerb R, Shi XY, Wei-Lavery T, Hoffman BB. Angiotensin II increases expression of cyclooxygenase-2: implications for the function of vascular smooth muscle cells. J Pharmacol Exp Ther. 2002 Nov; 303(2):563-73. PMID: 12388637.
    View in: PubMed
  14. Szeto HC, Coleman RK, Gholami P, Hoffman BB, Goldstein MK. Accuracy of computerized outpatient diagnoses in a Veterans Affairs general medicine clinic. Am J Manag Care. 2002 Jan; 8(1):37-43. PMID: 11814171.
    View in: PubMed
  15. Goldstein MK, Hoffman BB, Coleman RW, Tu SW, Shankar RD, O'Connor M, Martins S, Martins S, Advani A, Musen MA. Patient safety in guideline-based decision support for hypertension management: ATHENA DSS. Proc AMIA Symp. 2001; 214-8. PMID: 11825183; PMCID: PMC2243380.
  16. Chalon S, Moreno H, Benowitz NL, Hoffman BB, Blaschke TF. Nicotine impairs endothelium-dependent dilatation in human veins in vivo. Clin Pharmacol Ther. 2000 Apr; 67(4):391-7. PMID: 10801248.
    View in: PubMed
  17. Goldstein MK, Hoffman BB, Coleman RW, Musen MA, Tu SW, Advani A, Shankar R, O'Connor M. Implementing clinical practice guidelines while taking account of changing evidence: ATHENA DSS, an easily modifiable decision-support system for managing hypertension in primary care. Proc AMIA Symp. 2000; 300-4. PMID: 11079893; PMCID: PMC2243943.
  18. Duchna HW, Guilleminault C, Stoohs RA, Faul JL, Moreno H, Hoffman BB, Blaschke TF. Vascular reactivity in obstructive sleep apnea syndrome. Am J Respir Crit Care Med. 2000 Jan; 161(1):187-91. PMID: 10619819.
    View in: PubMed
  19. Hu JS, Durst M, Kerb R, Truong V, Ma JT, Khurgin E, Balaban D, Gingeras TR, Hoffman BB. Analysis of drug pharmacology towards predicting drug behavior by expression profiling using high-density oligonucleotide arrays. Ann N Y Acad Sci. 2000; 919:9-15. PMID: 11083092.
    View in: PubMed
  20. Hu ZW, Hoffman BB. Nuclear run-on assays for measurement of adrenergic receptor transcription rate. Methods Mol Biol. 2000; 126:169-80. PMID: 10685409.
    View in: PubMed
  21. Hoffman BB, Hu ZW. Alpha(1)-adrenoceptors (alpha(1)-AR) and vascular smooth muscle cell growth. Prostate Suppl. 2000; 9:29-33. PMID: 11056500.
    View in: PubMed
  22. Tangphao O, Chalon S, Moreno HJ, Abiose AK, Blaschke TF, Hoffman BB. Heparin-induced vasodilation in human hand veins. Clin Pharmacol Ther. 1999 Sep; 66(3):232-8. PMID: 10511058.
    View in: PubMed
  23. Han DC, Isono M, Hoffman BB, Ziyadeh FN. High glucose stimulates proliferation and collagen type I synthesis in renal cortical fibroblasts: mediation by autocrine activation of TGF-beta. J Am Soc Nephrol. 1999 Sep; 10(9):1891-9. PMID: 10477140.
    View in: PubMed
  24. Hu ZW, Shi XY, Lin RZ, Chen J, Hoffman BB. alpha1-Adrenergic receptor stimulation of mitogenesis in human vascular smooth muscle cells: role of tyrosine protein kinases and calcium in activation of mitogen-activated protein kinase. J Pharmacol Exp Ther. 1999 Jul; 290(1):28-37. PMID: 10381756.
    View in: PubMed
  25. Chen J, Lin R, Hu ZW, Hoffman BB. alpha1-adrenergic receptor activation of c-fos expression in transfected rat-1 fibroblasts: role of Ca2+. J Pharmacol Exp Ther. 1999 Jun; 289(3):1376-84. PMID: 10336529.
    View in: PubMed
  26. Chalon S, Moreno H, Hoffman BB, Blaschke TF. Angiotensin-converting enzyme inhibition improves venous endothelial dysfunction in chronic smokers. Clin Pharmacol Ther. 1999 Mar; 65(3):295-303. PMID: 10096262.
    View in: PubMed
  27. Tangphao O, Grossmann M, Chalon S, Hoffman BB, Blaschke TF. Pharmacokinetics of intravenous and oral L-arginine in normal volunteers. Br J Clin Pharmacol. 1999 Mar; 47(3):261-6. PMID: 10215749; PMCID: PMC2014227.
  28. Tangphao O, Chalon S, Moreno H, Hoffman BB, Blaschke TF. Pharmacokinetics of L-arginine during chronic administration to patients with hypercholesterolaemia. Clin Sci (Lond). 1999 Feb; 96(2):199-207. PMID: 9918901.
    View in: PubMed
  29. Hu ZW, Shi XY, Lin RZ, Hoffman BB. Contrasting signaling pathways of alpha1A- and alpha1B-adrenergic receptor subtype activation of phosphatidylinositol 3-kinase and Ras in transfected NIH3T3 cells. Mol Endocrinol. 1999 Jan; 13(1):3-14. PMID: 9892008.
    View in: PubMed
  30. Chalon S, Bedarida GV, Moreno H, Tejura B, Urae A, Hoffman BB, Blaschke TF. Inhibition of angiotensin-converting enzyme in human hand veins. Clin Pharmacol Ther. 1999 Jan; 65(1):58-65. PMID: 9951431.
    View in: PubMed
  31. Chalon S, Tejura B, Moreno H, Urae A, Blaschke TF, Hoffman BB. Role of nitric oxide in isoprenaline and sodium nitroprusside-induced relaxation in human hand veins. Br J Clin Pharmacol. 1999 Jan; 47(1):91-8. PMID: 10073745; PMCID: PMC2014212.
  32. Tangphao O, Chalon S, Coulston AM, Moreno H, Chan JR, Cooke JP, Hoffman BB, Blaschke TF. L-arginine and nitric oxide-related compounds in plasma: comparison of normal and arginine-free diets in a 24-h crossover study. Vasc Med. 1999; 4(1):27-32. PMID: 10355867.
    View in: PubMed
  33. Lin RZ, Chen J, Hu ZW, Hoffman BB. Phosphorylation of the cAMP response element-binding protein and activation of transcription by alpha1 adrenergic receptors. J Biol Chem. 1998 Nov 06; 273(45):30033-8. PMID: 9792725.
    View in: PubMed
  34. Moreno H, Chalon S, Urae A, Tangphao O, Abiose AK, Hoffman BB, Blaschke TF. Endothelial dysfunction in human hand veins is rapidly reversible after smoking cessation. Am J Physiol. 1998 Sep; 275(3 Pt 2):H1040-5. PMID: 9724311.
    View in: PubMed
  35. Hu ZW, Shi XY, Hoffman BB. Doxazosin inhibits proliferation and migration of human vascular smooth-muscle cells independent of alpha1-adrenergic receptor antagonism. J Cardiovasc Pharmacol. 1998 Jun; 31(6):833-9. PMID: 9641467.
    View in: PubMed
  36. Lin RZ, Hu ZW, Chin JH, Hoffman BB. Heat shock activates c-Src tyrosine kinases and phosphatidylinositol 3-kinase in NIH3T3 fibroblasts. J Biol Chem. 1997 Dec 05; 272(49):31196-202. PMID: 9388274.
    View in: PubMed
  37. Abiose AK, Grossmann M, Tangphao O, Hoffman BB, Blaschke TF. Chloroquine-induced venodilation in human hand veins. Clin Pharmacol Ther. 1997 Jun; 61(6):677-83. PMID: 9209251.
    View in: PubMed
  38. Grossmann M, Abiose A, Tangphao O, Blaschke TF, Hoffman BB. Morphine-induced venodilation in humans. Clin Pharmacol Ther. 1996 Nov; 60(5):554-60. PMID: 8941028.
    View in: PubMed
  39. Hu ZW, Shi XY, Hoffman BB. Insulin and insulin-like growth factor I differentially induce alpha1-adrenergic receptor subtype expression in rat vascular smooth muscle cells. J Clin Invest. 1996 Oct 15; 98(8):1826-34. PMID: 8878434; PMCID: PMC507622.
  40. Chin JH, Okazaki M, Frazier JS, Hu ZW, Hoffman BB. Impaired cAMP-mediated gene expression and decreased cAMP response element binding protein in senescent cells. Am J Physiol. 1996 Jul; 271(1 Pt 1):C362-71. PMID: 8760066.
    View in: PubMed
  41. Miller JW, Hu ZW, Okazaki M, Fujinaga M, Hoffman BB. Expression of alpha 1 adrenergic receptor subtype mRNAs in the rat cardiovascular system with aging. Mech Ageing Dev. 1996 Jun 07; 87(2):75-89. PMID: 8783191.
    View in: PubMed
  42. Chin JH, Okazaki M, Hu ZW, Miller JW, Hoffman BB. Activation of heat shock protein (hsp)70 and proto-oncogene expression by alpha1 adrenergic agonist in rat aorta with age. J Clin Invest. 1996 May 15; 97(10):2316-23. PMID: 8636412; PMCID: PMC507312.
  43. Thomas JM, Hoffman BB. Isoform-specific sensitization of adenylyl cyclase activity by prior activation of inhibitory receptors: role of beta gamma subunits in transducing enhanced activity of the type VI isoform. Mol Pharmacol. 1996 May; 49(5):907-14. PMID: 8622641.
    View in: PubMed
  44. Hu ZW, Shi XY, Lin RZ, Hoffman BB. Alpha1 adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular smooth muscle cells. Role in mitogenesis. J Biol Chem. 1996 Apr 12; 271(15):8977-82. PMID: 8621543.
    View in: PubMed
  45. Smith ER, Kacker SR, Raskin A, Yun PT, Davidson JM, Hoffman BB, Clark JT. Central propranolol and pindolol, but not atenolol nor metoprolol, inhibit sexual behavior in male rats. Physiol Behav. 1996 Feb; 59(2):241-6. PMID: 8838601.
    View in: PubMed
  46. Chin JH, Hiremath AN, Hoffman BB. cAMP signaling mechanisms with aging in rats. Mech Ageing Dev. 1996 Jan 05; 86(1):11-26. PMID: 8866733.
    View in: PubMed
  47. Okazaki M, Hu ZW, Fujinaga M, Hoffman BB. Alpha 1 adrenergic receptor activation of proto-oncogene expression in arterial smooth muscle: regulation by nitric oxide and vascular injury. Recept Signal Transduct. 1996; 6(3-4):165-78. PMID: 9259051.
    View in: PubMed
  48. Smith ER, Cetrulo EJ, Donahue JP, Sparrow H, Davidson JM, Hoffman BB, Clark JT. The inhibitory effects of propranolol on genital reflexes in male rats. Pharmacol Biochem Behav. 1995 Nov; 52(3):541-6. PMID: 8545471.
    View in: PubMed
  49. Thomas JM, Frazier JS, Hu ZW, Hoffman BB. Phosphorylation of cyclic AMP response element-binding protein and induction of c-fos gene expression on withdrawal from chronic treatment with carbachol in NG108-15 cells. Mol Pharmacol. 1995 Oct; 48(4):593-600. PMID: 7476883.
    View in: PubMed
  50. Fujinaga M, Hu ZW, Okazaki M, Baden JM, Hoffman BB. Expression of mRNA for alpha1-adrenoceptor subtypes at the beginning of neurulation in rat embryos. Toxicol In Vitro. 1995 Oct; 9(5):601-6. PMID: 20650135.
    View in: PubMed
  51. Bedarida G, Bushell E, Blaschke TF, Hoffman BB. H1- and H2-histamine receptor-mediated vasodilation varies with aging in humans. Clin Pharmacol Ther. 1995 Jul; 58(1):73-80. PMID: 7628185.
    View in: PubMed
  52. Smith ER, Stoker D, Kueny T, Davidson JM, Hoffman BB, Clark JT. The inhibition of sexual behavior in male rats by propranolol is stereoselective. Pharmacol Biochem Behav. 1995 Jun-Jul; 51(2-3):439-42. PMID: 7667366.
    View in: PubMed
  53. Bowersox SS, Miljanich GP, Sugiura Y, Li C, Nadasdi L, Hoffman BB, Ramachandran J, Ko CP. Differential blockade of voltage-sensitive calcium channels at the mouse neuromuscular junction by novel omega-conopeptides and omega-agatoxin-IVA. J Pharmacol Exp Ther. 1995 Apr; 273(1):248-56. PMID: 7714772.
    View in: PubMed
  54. Hu ZW, Shi XY, Okazaki M, Hoffman BB. Angiotensin II induces transcription and expression of alpha 1-adrenergic receptors in vascular smooth muscle cells. Am J Physiol. 1995 Mar; 268(3 Pt 2):H1006-14. PMID: 7900855.
    View in: PubMed
  55. Fujinaga M, Hoffman BB, Baden JM. Axial rotation in rat embryos: morphological analysis and microsurgical study on the role of the allantois. Teratology. 1995 Feb; 51(2):94-106. PMID: 7660327.
    View in: PubMed
  56. Ford GA, Dachman WD, Blaschke TF, Hoffman BB. Effect of aging on beta 2-adrenergic receptor-stimulated flux of K+, PO4, FFA, and glycerol in human forearms. J Appl Physiol (1985). 1995 Jan; 78(1):172-8. PMID: 7713808.
    View in: PubMed
  57. Okazaki M, Hu ZW, Fujinaga M, Hoffman BB. Alpha 1 adrenergic receptor-induced c-fos gene expression in rat aorta and cultured vascular smooth muscle cells. J Clin Invest. 1994 Jul; 94(1):210-8. PMID: 8040263; PMCID: PMC296299.
  58. Shilo L, Chin JH, Hoffman BB. Impaired beta-adrenergic receptor-mediated regulation of gene expression in adipocytes from older rats. Am J Physiol. 1994 Apr; 266(4 Pt 1):E659-65. PMID: 8178988.
    View in: PubMed
  59. Fujinaga M, Hoffman BB, Baden JM. Receptor subtype and intracellular signal transduction pathway associated with situs inversus induced by alpha 1 adrenergic stimulation in rat embryos. Dev Biol. 1994 Apr; 162(2):558-67. PMID: 8150214.
    View in: PubMed
  60. Dachman WD, Bedarida G, Blaschke TF, Hoffman BB. Histamine-induced venodilation in human beings involves both H1 and H2 receptor subtypes. J Allergy Clin Immunol. 1994 Mar; 93(3):606-14. PMID: 8151062.
    View in: PubMed
  61. Bedarida GV, Kim D, Blaschke TF, Hoffman BB. Characterization of an inhibitor of nitric oxide synthase in human-hand veins. Horm Metab Res. 1994 Feb; 26(2):109-12. PMID: 7515369.
    View in: PubMed
  62. Hu ZW, Miller JW, Hoffman BB. Induction of enhanced release of endothelium-derived relaxing factor after prolonged exposure to alpha-adrenergic agonists: role in desensitization of smooth muscle contraction. J Cardiovasc Pharmacol. 1994 Feb; 23(2):337-43. PMID: 7511767.
    View in: PubMed
  63. Sakaue M, Hoffman BB. Effects of cell density and conditioned medium on alpha 2A adrenergic receptor density and messenger RNA abundance in HT-29 cells. Life Sci. 1994; 54(23):1785-91. PMID: 8196492.
    View in: PubMed
  64. Shilo L, Sakaue M, Thomas JM, Philip M, Hoffman BB. Enhanced transcription of the human alpha 2A-adrenergic receptor gene by cAMP: evidence for multiple cAMP responsive sequences in the promoter region of this gene. Cell Signal. 1994 Jan; 6(1):73-82. PMID: 8011430.
    View in: PubMed
  65. Bedarida G, Kim D, Blaschke TF, Hoffman BB. Venodilation in Raynaud's disease. Lancet. 1993 Dec 11; 342(8885):1451-4. PMID: 7902481.
    View in: PubMed
  66. Hu ZW, Hoffman BB. Cycloheximide induces the alpha 1B adrenergic receptor gene by activation of transcription in DDT1 MF-2 smooth muscle cells. Mol Pharmacol. 1993 Dec; 44(6):1105-12. PMID: 8264546.
    View in: PubMed
  67. Bedarida GV, Bushell E, Haefeli WE, Blaschke TF, Hoffman BB. Responsiveness to bradykinin in veins of hypercholesterolemic humans. Circulation. 1993 Dec; 88(6):2754-61. PMID: 8252688.
    View in: PubMed
  68. Valentino K, Newcomb R, Gadbois T, Singh T, Bowersox S, Bitner S, Justice A, Yamashiro D, Hoffman BB, Ciaranello R, et al. A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia. Proc Natl Acad Sci U S A. 1993 Aug 15; 90(16):7894-7. PMID: 8102803; PMCID: PMC47249.
  69. Ford GA, Blaschke TF, Wiswell R, Hoffman BB. Effect of aging on changes in plasma potassium during exercise. J Gerontol. 1993 Jul; 48(4):M140-5. PMID: 8315226.
    View in: PubMed
  70. Deisher TA, Narita H, Zera P, Ginsburg R, Bristow MR, Billingham ME, Fowler MB, Hoffman BB. Protective effect of clentiazem against epinephrine-induced cardiac injury in rats. J Pharmacol Exp Ther. 1993 Jul; 266(1):262-9. PMID: 8392553.
    View in: PubMed
  71. Haefeli WE, Srivastava N, Kelsey KT, Wiencke JK, Hoffman BB, Blaschke TF. Glutathione S-transferase mu polymorphism does not explain variation in nitroglycerin responsiveness. Clin Pharmacol Ther. 1993 Apr; 53(4):463-8. PMID: 8477563.
    View in: PubMed
  72. Morrissette DL, Skinner MH, Hoffman BB, Levine RE, Davidson JM. Effects of antihypertensive drugs atenolol and nifedipine on sexual function in older men: a placebo-controlled, crossover study. Arch Sex Behav. 1993 Apr; 22(2):99-109. PMID: 8476337.
    View in: PubMed
  73. Hu ZW, Shi XY, Sakaue M, Hoffman BB. Prolonged activation of protein kinase C induces transcription and expression of the alpha 1B adrenergic receptor gene in DDT1 MF-2 cells. J Biol Chem. 1993 Feb 15; 268(5):3610-5. PMID: 8381435.
    View in: PubMed
  74. Swislocki AL, Vestal RE, Reaven GM, Hoffman BB. Acute metabolic effects of clonidine and adenosine in man. Horm Metab Res. 1993 Feb; 25(2):90-5. PMID: 8458615.
    View in: PubMed
  75. Haefeli WE, Srivastava N, Kongpatanakul S, Blaschke TF, Hoffman BB. Lack of role of endothelium-derived relaxing factor in effects of alpha-adrenergic agonists in cutaneous veins in humans. Am J Physiol. 1993 Feb; 264(2 Pt 2):H364-9. PMID: 8095374.
    View in: PubMed
  76. Haefeli WE, Bargetzi MJ, Starnes HF, Blaschke TF, Hoffman BB. Evidence for activation of the sympathetic nervous system by recombinant human interleukin-1 beta in humans. J Immunother Emphasis Tumor Immunol. 1993 Feb; 13(2):136-40. PMID: 8318499.
    View in: PubMed
  77. Dachman WD, Ford GA, Blaschke TF, Hoffman BB. Mechanism of bradykinin-induced venodilation in humans. J Cardiovasc Pharmacol. 1993 Feb; 21(2):241-8. PMID: 7679158.
    View in: PubMed
  78. Thomas JM, Hoffman BB. Buprenorphine prevents and reverses the expression of chronic etorphine-induced sensitization of adenylyl cyclase in SK-N-SH human neuroblastoma cells. J Pharmacol Exp Ther. 1993 Jan; 264(1):368-74. PMID: 8380866.
    View in: PubMed
  79. Haefeli WE, Gumbleton M, Benet LZ, Hoffman BB, Blaschke TF. Comparison of vasodilatory responses to nitroglycerin and its dinitrate metabolites in human veins. Clin Pharmacol Ther. 1992 Dec; 52(6):590-6. PMID: 1458768.
    View in: PubMed
  80. Vincent J, Kongpatanakul S, Blaschke TF, Hoffman BB. Desensitization of nitrate-induced venodilation: reversal with oral N-acetylcysteine in humans. J Cardiovasc Pharmacol. 1992 Dec; 20(6):907-12. PMID: 1282593.
    View in: PubMed
  81. Hu Z, Azhar S, Hoffman BB. Prolonged activation of alpha 1 adrenoceptors induces down-regulation of protein kinase C in vascular smooth muscle. J Cardiovasc Pharmacol. 1992 Dec; 20(6):982-9. PMID: 1282603.
    View in: PubMed
  82. Vincent J, Dachman W, Blaschke TF, Hoffman BB. Pharmacological tolerance to alpha 1-adrenergic receptor antagonism mediated by terazosin in humans. J Clin Invest. 1992 Nov; 90(5):1763-8. PMID: 1358918; PMCID: PMC443234.
  83. Thomas JM, Meier-Davis SR, Hoffman BB. Prolonged activation of inhibitory somatostatin receptors increases adenylate cyclase activity in wild-type and Gs alpha-deficient (cyc-) S49 mouse lymphoma cells. Cell Signal. 1992 Sep; 4(5):571-81. PMID: 1329904.
    View in: PubMed
  84. Dachman WD, Ford GA, Hoffman BB, Blaschke TF. Bradykinin-induced venodilation is not impaired with aging in humans. J Gerontol. 1992 Sep; 47(5):M166-70. PMID: 1512432.
    View in: PubMed
  85. Thomas JM, Hoffman BB. Adaptive increase in adenylyl cyclase activity in NG108-15 and S49 cells induced by chronic treatment with inhibitory drugs is not due to a decrease in cyclic AMP concentrations. Cell Signal. 1992 Jul; 4(4):417-28. PMID: 1329899.
    View in: PubMed
  86. Skinner MH, Futterman A, Morrissette D, Thompson LW, Hoffman BB, Blaschke TF. Atenolol compared with nifedipine: effect on cognitive function and mood in elderly hypertensive patients. Ann Intern Med. 1992 Apr 15; 116(8):615-23. PMID: 1546860.
    View in: PubMed
  87. Fujinaga M, Maze M, Hoffman BB, Baden JM. Activation of alpha-1 adrenergic receptors modulates the control of left/right sidedness in rat embryos. Dev Biol. 1992 Apr; 150(2):419-21. PMID: 1348038.
    View in: PubMed
  88. Costa EM, Hoffman BB, Loew GH. Assessment of delta-opioid receptor activation by a series of peptides in cultured cells. Int J Pept Protein Res. 1992 Mar; 39(3):245-9. PMID: 1328097.
    View in: PubMed
  89. Vincent J, Blaschke TF, Hoffman BB. Desensitization of beta-adrenoceptor- and prostaglandin E1 receptor-mediated human vascular smooth muscle relaxation. J Cardiovasc Pharmacol. 1992 Mar; 19(3):447-52. PMID: 1378128.
    View in: PubMed
  90. Eichler HG, Blaschke TF, Kraemer FB, Ford GA, Blöchl-Daum B, Hoffman BB. Responsiveness of superficial hand veins to alpha-adrenoceptor agonists in insulin-dependent diabetic patients. Clin Sci (Lond). 1992 Feb; 82(2):163-8. PMID: 1347259.
    View in: PubMed
  91. Hu ZW, Honda K, Murad F, Hoffman BB. Prolonged exposure to catecholamines enhances sensitivity of smooth muscle relaxation induced by sodium nitroprusside and atriopeptin. J Pharmacol Exp Ther. 1992 Feb; 260(2):756-61. PMID: 1346644.
    View in: PubMed
  92. Chin JH, Azhar S, Hoffman BB. Inactivation of endothelial derived relaxing factor by oxidized lipoproteins. J Clin Invest. 1992 Jan; 89(1):10-8. PMID: 1309534; PMCID: PMC442813.
  93. Bowersox SS, Singh T, Nadasdi L, Zukowska-Grojec Z, Valentino K, Hoffman BB. Cardiovascular effects of omega-conopeptides in conscious rats: mechanisms of action. J Cardiovasc Pharmacol. 1992; 20(5):756-64. PMID: 1280738.
    View in: PubMed
  94. Ford GA, Hoffman BB, Vestal RE, Blaschke TF. Age-related changes in adenosine and beta-adrenoceptor responsiveness of vascular smooth muscle in man. Br J Clin Pharmacol. 1992 Jan; 33(1):83-7. PMID: 1311596; PMCID: PMC1381203.
  95. Vincent J, Blaschke TF, Hoffman BB. Vascular reactivity to phenylephrine and angiotensin II: comparison of direct venous and systemic vascular responses. Clin Pharmacol Ther. 1992 Jan; 51(1):68-75. PMID: 1732078.
    View in: PubMed
  96. Ford GA, Hoffman BB, Blaschke TF. Beta adrenergically mediated cardiac chronotropic and vascular smooth muscle responses during propranolol therapy and withdrawal in young and elderly persons. J Gerontol. 1992 Jan; 47(1):M22-6. PMID: 1730849.
    View in: PubMed
  97. Hoffman BB. Adrenergic pharmacology in rats harboring pheochromocytoma. Hypertension. 1991 Nov; 18(5 Suppl):III35-9. PMID: 1657774.
    View in: PubMed
  98. Sakaue M, Hoffman BB. Glucocorticoids induce transcription and expression of the alpha 1B adrenergic receptor gene in DTT1 MF-2 smooth muscle cells. J Clin Invest. 1991 Aug; 88(2):385-9. PMID: 1650792; PMCID: PMC295342.
  99. Ford GA, Katzir D, Blaschke TF, Hoffman BB. Responsiveness of peripheral veins to vasodilators and the effect of nifedipine on alpha-adrenergic responsiveness in hypertension. Clin Pharmacol Ther. 1991 Aug; 50(2):192-8. PMID: 1651200.
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  100. Hiremath AN, Hu ZW, Hoffman BB. Desensitization of alpha-adrenergic receptor-mediated smooth muscle contraction: role of the endothelium. J Cardiovasc Pharmacol. 1991 Jul; 18(1):151-7. PMID: 1719284.
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  101. Twersky J, Hoffman BB, Reaven GM. Age-associated differences in beta adrenergic-stimulated lipolysis in adipocytes from Sprague-Dawley and Fischer 344 rats. J Gerontol. 1991 Jul; 46(4):B125-9. PMID: 2071826.
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  102. Sakaue M, Hoffman BB. cAMP regulates transcription of the alpha 2A adrenergic receptor gene in HT-29 cells. J Biol Chem. 1991 Mar 25; 266(9):5743-9. PMID: 1848558.
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  103. Chin JH, Hoffman BB. Beta-adrenergic responsiveness in cultured vascular smooth muscle cells and fibroblasts: effect of age. Mech Ageing Dev. 1991 Mar; 57(3):259-73. PMID: 1647473.
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  104. Sheu WH, Swislocki AL, Hoffman BB, Reaven GM, Chen YD. Effect of prazosin treatment on HDL kinetics in patients with hypertension. Am J Hypertens. 1990 Oct; 3(10):761-8. PMID: 2121164.
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  105. Eichler HG, Blaschke TF, Hoffman BB. Decreased responsiveness of superficial hand veins to phenylephrine in black normotensive males. J Cardiovasc Pharmacol. 1990 Aug; 16(2):177-81. PMID: 1697371.
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  106. Reaven GM, Ho H, Hoffman BB. Effects of a fructose-enriched diet on plasma insulin and triglyceride concentration in SHR and WKY rats. Horm Metab Res. 1990 Jul; 22(7):363-5. PMID: 2205554.
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  107. Chin JH, Hoffman BB. Age-related deficit in beta receptor stimulation of cAMP binding in blood vessels. Mech Ageing Dev. 1990 Apr 09; 53(2):111-25. PMID: 2160570.
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  108. Thomas JM, Vagelos R, Hoffman BB. Decreased cyclic AMP degradation in NG 108-15 neuroblastoma X glioma hybrid cells and S49 lymphoma cells chronically treated with drugs that inhibit adenylate cyclase. J Neurochem. 1990 Feb; 54(2):402-10. PMID: 1688917.
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  109. Thomas JM, Hoffman BB. Activation of muscarinic cholinergic receptors in mouse neuroblastoma x rat glioma hybrid cells: rapid induction of enhanced capacity of prostaglandin E1 receptors to stimulate cyclic AMP accumulation. J Pharmacol Exp Ther. 1990 Feb; 252(2):616-22. PMID: 2156056.
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  110. Hu ZW, Billingham M, Tuck M, Hoffman BB. Captopril improves hypertension and cardiomyopathy in rats with pheochromocytoma. Hypertension. 1990 Feb; 15(2):210-5. PMID: 2154406.
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  111. Ford GA, Hoffman BB, Blaschke TF. Effect of temazepam on blood pressure regulation in healthy elderly subjects. Br J Clin Pharmacol. 1990 Jan; 29(1):61-7. PMID: 1967533; PMCID: PMC1380062.
  112. Reaven GM, Hoffman BB. Hypertension as a disease of carbohydrate and lipoprotein metabolism. Am J Med. 1989 Dec 08; 87(6A):2S-6S. PMID: 2688409.
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  113. Hiremath AN, Hoffman BB, Blaschke TF. Responsiveness of peripheral veins to transdermal and sublingual nitroglycerin in healthy male volunteers. J Cardiovasc Pharmacol. 1989 Oct; 14(4):534-41. PMID: 2478766.
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  114. Reaven GM, Chang H, Hoffman BB, Azhar S. Resistance to insulin-stimulated glucose uptake in adipocytes isolated from spontaneously hypertensive rats. Diabetes. 1989 Sep; 38(9):1155-60. PMID: 2670644.
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  115. Munoz E, Tsujimoto G, Tsujimoto A, Azhar S, Hoffman BB. Desensitization of alpha 1 adrenoceptor-stimulated glycogen phosphorylase activity in vascular smooth muscle. J Cardiovasc Pharmacol. 1989 Aug; 14(2):278-84. PMID: 2476602.
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  116. Deisher TA, Mankani S, Hoffman BB. Role of cyclic AMP-dependent protein kinase in the diminished beta adrenergic responsiveness of vascular smooth muscle with increasing age. J Pharmacol Exp Ther. 1989 Jun; 249(3):812-9. PMID: 2543812.
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  117. Swislocki AL, Hoffman BB, Reaven GM. Insulin resistance, glucose intolerance and hyperinsulinemia in patients with hypertension. Am J Hypertens. 1989 Jun; 2(6 Pt 1):419-23. PMID: 2667570.
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  118. Hoffman BB, Prokocimer P, Thomas JM, Vagelos R, Chang H, Reaven GM. Cellular tolerance to adenosine receptor-mediated inhibition of lipolysis: altered adenosine 3',5'-monophosphate metabolism and protein kinase activation. Endocrinology. 1989 May; 124(5):2434-42. PMID: 2539980.
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  119. Reaven GM, Chang H, Hoffman BB. Impaired insulin-mediated inhibition of lipolysis and glucose transport with aging. Horm Metab Res. 1989 Apr; 21(4):168-71. PMID: 2666294.
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  120. Eichler HG, Eichler I, Lewiston N, Blaschke TF, Hoffman BB. Responsiveness of superficial hand veins to adrenergic stimuli in patients with cystic fibrosis. Clin Sci (Lond). 1989 Mar; 76(3):283-7. PMID: 2924520.
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  121. Tsujimoto G, Hashimoto K, Hoffman BB. Pharmacokinetic and pharmacodynamic principles of drug therapy in old age. Part 2. Int J Clin Pharmacol Ther Toxicol. 1989 Mar; 27(3):102-16. PMID: 2656543.
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  122. Swislocki AL, Hoffman BB, Sheu WH, Chen YD, Reaven GM. Effect of prazosin treatment on carbohydrate and lipoprotein metabolism in patients with hypertension. Am J Med. 1989 Jan 23; 86(1B):14-8. PMID: 2643861.
    View in: PubMed
  123. Thomas JM, Hoffman BB. Chronic somatostatin treatment induces enhanced forskolin-stimulated cAMP accumulation in wild-type S49 mouse lymphoma cells but not in protein kinase-deficient mutants. Mol Pharmacol. 1989 Jan; 35(1):116-24. PMID: 2563303.
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  124. Eichler HG, Ford GA, Blaschke TF, Swislocki A, Hoffman BB. Responsiveness of superficial hand veins to phenylephrine in essential hypertension. Alpha adrenergic blockade during prazosin therapy. J Clin Invest. 1989 Jan; 83(1):108-12. PMID: 2562959; PMCID: PMC303650.
  125. Hiremath AN, Pershe RA, Hoffman BB, Blaschke TF. Comparison of age-related changes in prostaglandin E1 and beta-adrenergic responsiveness of vascular smooth muscle in adult males. J Gerontol. 1989 Jan; 44(1):M13-7. PMID: 2536054.
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  126. Tsujimoto G, Hashimoto K, Hoffman BB. Pharmacokinetic and pharmacodynamic principles of drug therapy in old age. Part 1. Int J Clin Pharmacol Ther Toxicol. 1989 Jan; 27(1):13-26. PMID: 2663734.
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  127. Ford GA, Eichler HG, Hoffman BB, Blaschke TF. Venous responsiveness to atrial natriuretic factor in man. Br J Clin Pharmacol. 1988 Dec; 26(6):797-9. PMID: 2977285; PMCID: PMC1386598.
  128. Bristow MR, Minobe W, Rasmussen R, Hershberger RE, Hoffman BB. Alpha-1 adrenergic receptors in the nonfailing and failing human heart. J Pharmacol Exp Ther. 1988 Dec; 247(3):1039-45. PMID: 2849656.
    View in: PubMed
  129. Reaven GM, Ho H, Hoffman BB. Attenuation of fructose-induced hypertension in rats by exercise training. Hypertension. 1988 Aug; 12(2):129-32. PMID: 3410522.
    View in: PubMed
  130. Prokocimer PG, Maze M, Vickery RG, Hoffman BB. Mechanism for desensitization of beta-adrenergic receptor-stimulated lipolysis in adipocytes from rats harboring pheochromocytoma. Endocrinology. 1988 Jul; 123(1):528-33. PMID: 2838264.
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  131. Prokocimer PG, Maze M, Vickery RG, Kraemer FB, Gandjei R, Hoffman BB. Mechanism of halothane-induced inhibition of isoproterenol-stimulated lipolysis in isolated rat adipocytes. Mol Pharmacol. 1988 Mar; 33(3):338-43. PMID: 3352597.
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  132. Reaven GM, Hoffman BB. Abnormalities of carbohydrate metabolism may play a role in the etiology and clinical course of hypertension. Trends Pharmacol Sci. 1988 Mar; 9(3):78-9. PMID: 3072736.
    View in: PubMed
  133. Reaven GM, Chang H, Ho H, Jeng CY, Hoffman BB. Lowering of plasma glucose in diabetic rats by antilipolytic agents. Am J Physiol. 1988 Jan; 254(1 Pt 1):E23-30. PMID: 2962514.
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  134. Reaven GM, Chang H, Hoffman BB. Additive hypoglycemic effects of drugs that modify free-fatty acid metabolism by different mechanisms in rats with streptozocin-induced diabetes. Diabetes. 1988 Jan; 37(1):28-32. PMID: 3275556.
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  135. Rosenbaum JS, Billingham ME, Ginsburg R, Tsujimoto G, Lurie KG, Hoffman BB. Cardiomyopathy in a rat model of pheochromocytoma. Morphological and functional alterations. Am J Cardiovasc Pathol. 1988; 1(3):389-99. PMID: 3207483.
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  136. Rosenbaum JS, Azhar S, Hoffman BB. Alpha 1 adrenergic receptor mediated polyphosphoinositide breakdown in DDT1-MF2 cells. Lack of evidence of desensitization after prolonged exposure to epinephrine. Biochem Pharmacol. 1987 Dec 15; 36(24):4335-40. PMID: 2825723.
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  137. Oates J, Lowenthal DT, Kane RL, Hoffman BB, Beck JC. The concept of geriatric clinical pharmacology. Panel II: Assessing progress and value of training programs. Clin Pharmacol Ther. 1987 Dec; 42(6):702-4. PMID: 3690952.
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  138. Hwang IS, Ho H, Hoffman BB, Reaven GM. Fructose-induced insulin resistance and hypertension in rats. Hypertension. 1987 Nov; 10(5):512-6. PMID: 3311990.
    View in: PubMed
  139. Hoffman BB. Observations in New England Deaconess Hospital rats harboring pheochromocytoma. Clin Invest Med. 1987 Nov; 10(6):555-60. PMID: 2831003.
    View in: PubMed
  140. Eichler HG, Hiremath A, Katzir D, Blaschke TF, Hoffman BB. Absence of age-related changes in venous responsiveness to nitroglycerin in vivo in humans. Clin Pharmacol Ther. 1987 Nov; 42(5):521-4. PMID: 3119271.
    View in: PubMed
  141. Reaven GM, Hoffman BB. A role for insulin in the aetiology and course of hypertension? Lancet. 1987 Aug 22; 2(8556):435-7. PMID: 2887735.
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  142. Hoffman BB, Chang H, Reaven GM. Stimulation and inhibition of lipolysis in isolated rat adipocytes: evidence for age-related changes in responses to forskolin and PGE1. Horm Metab Res. 1987 Aug; 19(8):358-60. PMID: 2822560.
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  143. Tsujimoto G, Minegishi A, Ishizaki T, Hoffman BB, Hashimoto K. Characterization of vasopressor response to sympathetic stimulation in the pithed rat: differential regulation of neuronally stimulated and blood-borne catecholamine-stimulated pressor responses in rats harboring pheochromocytoma. J Pharmacol Exp Ther. 1987 Aug; 242(2):637-45. PMID: 2886647.
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  144. Tsujimoto G, Honda K, Hoffman BB, Hashimoto K. Desensitization of postjunctional alpha 1- and alpha 2-adrenergic receptor-mediated vasopressor responses in rat harboring pheochromocytoma. Circ Res. 1987 Jul; 61(1):86-98. PMID: 3038368.
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  145. Khan MM, Marr-Leisy D, Rosenkranz R, Hoffman BB, Verlander MS, Goodman M, Melmon KL. In vitro pharmacologic activity of congener derivatives and model conjugates of propranolol and practolol. Biochem Pharmacol. 1987 Jul 01; 36(13):2175-82. PMID: 3038116.
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  146. Prokocimer PG, Maze M, Hoffman BB. Role of the sympathetic nervous system in the maintenance of hypertension in rats harboring pheochromocytoma. J Pharmacol Exp Ther. 1987 Jun; 241(3):870-4. PMID: 3598906.
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  147. Rosenbaum JS, Ginsburg R, Billingham ME, Hoffman BB. Effects of adrenergic receptor antagonists on cardiac morphological and functional alterations in rats harboring pheochromocytoma. J Pharmacol Exp Ther. 1987 Apr; 241(1):354-60. PMID: 2883296.
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  148. Tsujimoto G, Hashimoto K, Hoffman BB. Effects of thyroid hormone on beta-adrenergic responsiveness of aging cardiovascular systems. Am J Physiol. 1987 Mar; 252(3 Pt 2):H513-20. PMID: 3030139.
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  149. Garfinkel D, Hoffman BB. Therapeutic rounds. Digitalis toxicity. Clin Ther. 1987; 9(4):358-9, 434-5. PMID: 3607816.
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  150. Garfinkel D, Glazener F, Hoffman BB. Metronidazole interferes with theophylline measurements. Ann Intern Med. 1987 Jan; 106(1):171. PMID: 3789570.
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  151. Pan HY, Hoffman BB, Pershe RA, Blaschke TF. Decline in beta adrenergic receptor-mediated vascular relaxation with aging in man. J Pharmacol Exp Ther. 1986 Dec; 239(3):802-7. PMID: 3025419.
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  152. Hoffman BB, Dall'Aglio E, Hollenbeck C, Chang H, Reaven GM. Suppression of free fatty acids and triglycerides in normal and hypertriglyceridemic rats by the adenosine receptor agonist phenylisopropyladenosine. J Pharmacol Exp Ther. 1986 Dec; 239(3):715-8. PMID: 3795036.
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  153. Tsujimoto G, Lee CH, Hoffman BB. Age-related decrease in beta adrenergic receptor-mediated vascular smooth muscle relaxation. J Pharmacol Exp Ther. 1986 Nov; 239(2):411-5. PMID: 2430092.
    View in: PubMed
  154. Thomas JM, Hoffman BB. Agonist-induced down-regulation of muscarinic cholinergic and alpha 2-adrenergic receptors after inactivation of Ni by pertussis toxin. Endocrinology. 1986 Sep; 119(3):1305-14. PMID: 2426098.
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  155. Rosenbaum JS, Zera P, Umans VA, Ginsburg R, Hoffman BB. Desensitization of aortic smooth muscle contraction in rats harboring pheochromocytoma. J Pharmacol Exp Ther. 1986 Aug; 238(2):396-400. PMID: 3016236.
    View in: PubMed
  156. Hoffman BB, Chang H, Dall'Aglio E, Reaven GM. Desensitization of adenosine receptor-mediated inhibition of lipolysis. The mechanism involves the development of enhanced cyclic adenosine monophosphate accumulation in tolerant adipocytes. J Clin Invest. 1986 Jul; 78(1):185-90. PMID: 3013937; PMCID: PMC329548.
  157. Tsujimoto A, Tsujimoto G, Azhar S, Hoffman BB. Altered responsiveness to alpha- and beta-adrenoceptor stimulation in hepatocytes cultured in defined medium. Biochem Pharmacol. 1986 Apr 15; 35(8):1400-4. PMID: 2870718.
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  158. Tsujimoto G, Timmins PV, Hoffman BB. Alpha adrenergic receptors in the rabbit bladder base smooth muscle: alpha-1 adrenergic receptors mediate contractile responses. J Pharmacol Exp Ther. 1986 Feb; 236(2):384-9. PMID: 2868117.
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  159. Thomas JM, Hoffman BB. Muscarinic cholinergic receptor-induced enhancement of PGE1-stimulated cAMP accumulation in neuroblastoma X glioma cells: prevention by pertussis toxin. J Cyclic Nucleotide Protein Phosphor Res. 1986; 11(4):317-25. PMID: 3025278.
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  160. Tsujimoto A, Tsujimoto G, Hoffman BB. Age-related change in adrenergic regulation of glycogen phosphorylase in rat hepatocytes. Mech Ageing Dev. 1986 Jan; 33(2):167-75. PMID: 3007877.
    View in: PubMed
  161. Maze M, Spiss CK, Tsujimoto G, Hoffman BB. Epinephrine infusion induces hyporesponsiveness of vascular smooth muscle. Life Sci. 1985 Oct 28; 37(17):1571-8. PMID: 2997566.
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  162. Lurie KG, Chin JH, Hoffman BB. Decreased membrane fluidity and beta-adrenergic responsiveness in atherosclerotic quail. Am J Physiol. 1985 Aug; 249(2 Pt 2):H380-5. PMID: 2992295.
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  163. Tsujimoto G, Hashimoto K, Hoffman BB. Effects of pheochromocytoma on cardiovascular alpha adrenergic receptor system. Heart Vessels. 1985 Aug; 1(3):152-7. PMID: 3007429.
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  164. Lurie KG, Tsujimoto G, Hoffman BB. Desensitization of alpha-1 adrenergic receptor-mediated vascular smooth muscle contraction. J Pharmacol Exp Ther. 1985 Jul; 234(1):147-52. PMID: 2989501.
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  165. García-Sáinz JA, Villalobos-Molina R, Corvera S, Huerta-Bahena J, Tsujimoto G, Hoffman BB. Differential effects of adrenergic agonists and phorbol esters on the alpha 1-adrenoceptors of hepatocytes and aorta. Eur J Pharmacol. 1985 Jun 19; 112(3):393-7. PMID: 2862055.
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  166. Reitz AB, Avery MA, Rosenkranz RP, Verlander MS, Melmon KL, Hoffman BB, Akita Y, Castagnoli N, Goodman M. Conjugates of catecholamines. 6. Synthesis and beta-adrenergic activity of N-(hydroxyalkyl)catecholamine derivatives. J Med Chem. 1985 May; 28(5):642-7. PMID: 2859373.
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  167. Manger WM, Gifford RW, Hoffman BB. Pheochromocytoma: a clinical and experimental overview. Curr Probl Cancer. 1985 May; 9(5):1-89. PMID: 3021396.
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  168. Reitz AB, Sonveaux E, Rosenkranz RP, Verlander MS, Melmon KL, Hoffman BB, Akita Y, Castagnoli N, Goodman M. Conjugates of catecholamines. 5. Synthesis and beta-adrenergic activity of N-(aminoalkyl)norepinephrine derivatives. J Med Chem. 1985 May; 28(5):634-42. PMID: 2859372.
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  169. Tsujimoto G, Hoffman BB. Desensitization of beta-adrenergic receptor-mediated vascular smooth muscle relaxation. Mol Pharmacol. 1985 Feb; 27(2):210-7. PMID: 2578603.
    View in: PubMed
  170. Hoffman BB, Tsujimoto G. Direct measurement of vascular alpha 1-adrenoceptors. Clin Sci (Lond). 1985; 68 Suppl 10:35s-37s. PMID: 2857616.
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  171. Spiss CK, Smith CM, Tsujimoto G, Hoffman BB, Maze M. Prolonged hyporesponsiveness of vascular smooth muscle contraction after halothane anesthesia in rabbits. Anesth Analg. 1985 Jan; 64(1):1-6. PMID: 2981487.
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  172. Hoffman BB, Chang H, Farahbakhsh ZT, Reaven GM. Age-related decrement in hormone-stimulated lipolysis. Am J Physiol. 1984 Dec; 247(6 Pt 1):E772-7. PMID: 6150643.
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  173. Hoffman BB, Chang H, Farahbakhsh Z, Reaven G. Inhibition of lipolysis by adenosine is potentiated with age. J Clin Invest. 1984 Nov; 74(5):1750-5. PMID: 6094613; PMCID: PMC425354.
  174. Tsujimoto G, Manger WM, Hoffman BB. Desensitization of beta-adrenergic receptors by pheochromocytoma. Endocrinology. 1984 Apr; 114(4):1272-8. PMID: 6323140.
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  175. Tsujimoto G, Bristow MR, Hoffman BB. Identification of alpha 1 adrenergic receptors in rabbit aorta with [125I] BE2254. Life Sci. 1984 Feb 13; 34(7):639-46. PMID: 6321870.
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  176. Manger WM, Hoffman BB. Heart imaging in the diagnosis of pheochromocytoma and assessment of catecholamine uptake. J Nucl Med. 1983 Dec; 24(12):1194-6. PMID: 6644382.
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  177. Rosenkranz RP, Hoffman BB, Jacobson KA, Verlander MS, Klevans L, O'Donnell M, Goodman M, Melmon KL. Conjugates of catecholamines. II. In vitro and in vivo pharmacological activity of N-alkyl-functionalized carboxylic acid congeners and amides related to isoproterenol. Mol Pharmacol. 1983 Nov; 24(3):429-35. PMID: 6138706.
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  178. Hoffman BB. Regulation of alpha and beta adrenergic receptors in man. Clin Endocrinol Metab. 1983 Mar; 12(1):1-13. PMID: 6342875.
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  179. Stiles GL, Hoffman BB, Hubbard M, Caron MG, Lefkowitz RJ. Guanine nucleotides and alpha 1 adrenergic receptors in the heart. Biochem Pharmacol. 1983 Jan 01; 32(1):69-71. PMID: 6299299.
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  180. Hoffman BB, Michel T, Brenneman TB, Lefkowitz RJ. Interactions of agonists with platelet alpha 2-adrenergic receptors. Endocrinology. 1982 Mar; 110(3):926-32. PMID: 6120077.
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  181. Hoffman BB, Lefkowitz RJ. Adrenergic receptors in the heart. Annu Rev Physiol. 1982; 44:475-84. PMID: 6280590.
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  182. Hoffman BB, Lefkowitz RJ. Agonist interactions with alpha-adrenergic receptors. J Cardiovasc Pharmacol. 1982; 4 Suppl 1:S14-8. PMID: 6175829.
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  183. Garcia-Sáinz JA, Litosch I, Hoffman BB, Lefkowitz RJ, Fain JN. Effect of thyroid status on alpha- and beta-catecholamine responsiveness of hamster adipocytes. Biochim Biophys Acta. 1981 Dec 18; 678(3):334-41. PMID: 6274417.
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  184. Hoffman BB, Lavin TN, Lefkowitz RJ, Ruffolo RR. Alpha adrenergic receptor subtypes in rabbit uterus: mediation of myometrial contraction and regulation by estrogens. J Pharmacol Exp Ther. 1981 Nov; 219(2):290-5. PMID: 6270302.
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  185. Lavin TN, Hoffman BB, Lefkowitz RJ. Determination of subtype selectivity of alpha-adrenergic antagonists: comparison of selective and nonselective radioligands. Mol Pharmacol. 1981 Jul; 20(1):28-34. PMID: 6117003.
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  186. Michel T, Hoffman BB, Lefkowitz RJ, Caron MG. Different sedimentation properties of agonist- and antagonist-labelled platelet alpha 2 adrenergic receptors. Biochem Biophys Res Commun. 1981 Jun 16; 100(3):1131-6. PMID: 6268079.
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  187. Hoffman BB, Yim S, Tsai BS, Lefkowitz RJ. Preferential uncoupling by manganese of alpha adrenergic receptor mediated inhibition of adenylate cyclase in human platelets. Biochem Biophys Res Commun. 1981 May 29; 100(2):724-31. PMID: 6268073.
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  188. Tharp MD, Hoffman BB, Lefkowitz RJ. alpha-Adrenergic receptors in human adipocyte membranes: direct determination by [3H]yohimbine binding. J Clin Endocrinol Metab. 1981 Apr; 52(4):709-14. PMID: 6110673.
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  189. Burns TW, Langley PE, Terry BE, Bylund DB, Hoffman BB, Tharp MD, Lefkowitz RJ, García-Saínz JA, Fain JN. Pharmacological characterizations of adrenergic receptors in human adipocytes. J Clin Invest. 1981 Feb; 67(2):467-75. PMID: 6257762; PMCID: PMC370588.
  190. Hoffman BB, Dukes DF, Lefkowitz RJ. Alpha-adrenergic receptors in liver membranes: delineation with subtype selective radioligands. Life Sci. 1981 Jan 19; 28(3):265-72. PMID: 6261059.
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  191. Lefkowitz RJ, De Lean A, Hoffman BB, Stadel JM, Kent R, Michel T, Limbird L. Molecular pharmacology of adenylate cyclase-coupled alpha- and beta-adrenergic receptors. Adv Cyclic Nucleotide Res. 1981; 14:145-61. PMID: 6269377.
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  192. Michel T, Hoffman BB, Lefkowitz RJ. Differential regulation of the alpha 2-adrenergic receptor by Na+ and guanine nucleotides. Nature. 1980 Dec 25; 288(5792):709-11. PMID: 6256638.
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  193. García-Sínz JA, Hoffman BB, Li SY, Lefkowitz RJ, Fain JN. Role of alpha 1 adrenoceptors in the turnover of phosphatidylinositol and of alpha 2 adrenoceptors in the regulation of cyclic AMP accumulation in hamster adipocytes. Life Sci. 1980 Sep 15; 27(11):953-61. PMID: 6107811.
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  194. Hoffman BB, Michel T, Kilpatrick DM, Lefkowitz RJ, Tolbert ME, Gilman H, Fain JN. Agonist versus antagonist binding to alpha-adrenergic receptors. Proc Natl Acad Sci U S A. 1980 Aug; 77(8):4569-73. PMID: 6107908; PMCID: PMC349885.
  195. Hoffman BB, Lefkowitz RJ. Peripheral alpha-adrenergic receptor subtypes. Psychopharmacol Bull. 1980 Jul; 16(3):90-1. PMID: 6250184.
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  196. Hoffman BB, Lefkowitz RJ. Alpha-adrenergic receptor subtypes. N Engl J Med. 1980 Jun 19; 302(25):1390-6. PMID: 6246426.
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  197. Hoffman BB, Lefkowitz RJ. [3H]WB4101--caution about its role as an alpha-adrenergic subtype selective radioligand. Biochem Pharmacol. 1980 Jun 01; 29(11):1537-41. PMID: 6249320.
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  198. Hoffman BB, Mullikin-Kilpatrick D, Lefkowitz RJ. Heterogeneity of radioligand binding to alpha-adrenergic receptors. Analysis of guanine nucleotide regulation of agonist binding in relation to receptor subtypes. J Biol Chem. 1980 May 25; 255(10):4645-52. PMID: 6246079.
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  199. Hoffman BB, Lefkowitz RJ. An assay for alpha-adrenergic receptor subtypes using [3H]dihydroergocryptine. Biochem Pharmacol. 1980 Feb; 29(3):452-4. PMID: 6244840.
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  200. Hoffman BB, Lefkowitz RJ. Radioligand binding studies of adrenergic receptors: new insights into molecular and physiological regulation. Annu Rev Pharmacol Toxicol. 1980; 20:581-608. PMID: 6247962.
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  201. Lefkowitz RJ, Hoffman BB. Adrenergic receptors. Adv Cyclic Nucleotide Res. 1980; 12:37-47. PMID: 6250368.
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  202. Hoffman BB, Mullikin-Kilpatrick D, Lefkowitz RJ. Desensitization of beta-adrenergic stimulated adenylate cyclase in turkey erythrocytes. J Cyclic Nucleotide Res. 1979 Oct; 5(5):355-66. PMID: 230209.
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  203. Hoffman BB, De Lean A, Wood CL, Schocken DD, Lefkowitz RJ. Alpha-adrenergic receptor subtypes: quantitative assessment by ligand binding. Life Sci. 1979 May 07; 24(19):1739-45. PMID: 222980.
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