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Daniel B. Hoch, M.D., Ph.D.

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Augustus Rose Teaching Award
Partners in Excellence Award
Elected Fellow
Nominated Nathaniel Bowditch Award
Elected Fellow

Research Activities:
My current research projects include both funded and unfunded efforts in two areas, medical informatics, especially health-related computing by patients, and the evaluation and management of epilepsy.

I have exchanged email with patients since the early 1990’s and have observed patient activities in health-related discussion groups since about 1995. As a consequence of those observations, my colleagues and I developed and are studying patient-centered applications on the World Wide Web. Over the last 7 years, we’ve used interviews, focus groups and other qualitative methods to understand how patients use these resources and how best to serve them in our own practice. I’ve received funding from the National Library of Medicine and the Research Council of Partners Healthcare to further these studies.

My research into the evaluation and management of epilepsy has included being site PI on a large NIH-funded multicenter study of early surgery for epilepsy related to mesial temporal sclerosis. I’ve also been involved in several randomized control trials of anticonvulsant drugs and new devices. In the latter category, we are presently preparing to take part in a trial of an implantable device that performs seizure detection and brain stimulation to prevent seizures. Finally, I am collaborating with the behavioral medicine group at MGH to examine the impact of cognitive behavioral therapy on seizures and the severity of epilepsy. We are currently seeking funding for that effort.
Teaching Activities:
I presently teach medical students, residents and fellows at the MGH. I interact with medical students during attending duties for one or two months each year and I also take part in the teaching/evaluation oral examination at the conclusion of their neurology rotation several times a year. I give regular lectures to both residents and students in the context of noon teaching conferences, and serve as preceptor for the residents each week in the outpatient area. My fellows and I learn from each other at weekly EEG reading sessions, at weekly outpatient clinic sessions and during inpatient rounds on the epilepsy monitoring unit. Clinical Activities:
I presently see up to 20 outpatients at each of two half-day sessions each week, one general neurology session with residents and one epilepsy session with fellows. I also see my own epilepsy patients and perform consultation on new patients during one half-day session each week. The use of email and a secure, WWW-based resource to exchange messages with patients has resulted in our ability to manage more patients and problems than in the past and I’ve estimated that there are about 500 patients in my panel at this time. Lastly, I am the inpatient attending of record on the general neurology service up to two months yearly, read EEGs one morning every week and read the epilepsy monitoring studies daily during 3 months each year.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. G08LM006964 (HOCH, DANIEL B) Feb 25, 2001 - Jan 31, 2005
    Role: Principal Investigator
  2. M01RR001066 (SLAVIN, PETER L) Dec 1, 1997 - Nov 30, 2007
    General Clinical Research Center
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hoch DB, Watson AJ, Linton DA, Bello HE, Senelly M, Milik MT, Baim MA, Jethwani K, Fricchione GL, Benson H, Kvedar JC. Correction: The Feasibility and Impact of Delivering a Mind-Body Intervention in a Virtual World. PLoS One. 2017; 12(2):e0172863. PMID: 28222137.
    Citations:    Fields:    
  2. Hoch DB, Watson AJ, Linton DA, Bello HE, Senelly M, Milik MT, Baim MA, Jethwani K, Fricchione GL, Benson H, Kvedar JC. The feasibility and impact of delivering a mind-body intervention in a virtual world. PLoS One. 2012; 7(3):e33843. PMID: 22470483.
    Citations: 8     Fields:    Translation:Humans
  3. Herzog AG, Blum AS, Farina EL, Maestri XE, Newman J, Garcia E, Krishnamurthy KB, Hoch DB, Replansky S, Fowler KM, Smithson SD, Dworetzky BA, Bromfield EB. Valproate and lamotrigine level variation with menstrual cycle phase and oral contraceptive use. Neurology. 2009 Mar 10; 72(10):911-4. PMID: 19273825.
    Citations: 10     Fields:    Translation:Humans
  4. Linton D, Senelly M, Baim M, Bello H, Millik MT, Watson A, Hoch DB. Translating medical practice from the real to the virtual: adapting an existing clinical program to a virtual world. AMIA Annu Symp Proc. 2008 Nov 06; 1026. PMID: 18999294.
    Citations: 2     Fields:    
  5. Watson AJ, Grant RW, Bello H, Hoch DB. Brave new worlds: how virtual environments can augment traditional care in the management of diabetes. J Diabetes Sci Technol. 2008 Jul; 2(4):697-702. PMID: 19885247.
    Citations: 8     Fields:    
  6. B. Leeman, B. Moo, L. Leveroni, C. Cole, A. Schachter, S. Hoch, D. Associations of lamotrigine therapy with changes in cognition and interictal discharges: a pilot study in adults . Epilepsia. 2007.
  7. Costello, D. Kilbride, R. Michaelides, C. Cash, S. Chiappa, K. Hoch, D. Cole, AJ. DE NOVO Cryptogenic Refractory Status Epilepticus- What is it?. Epilepsia. 2007; 48(s6):16.
  8. Herzog, AG Blum, AS. Farina, EL. Maestri, Xe. Garcia, E. Selvitelli, M. Krishnamurthy, KB. Hoch, DB. Replansky, S. Dworetzky, BA. Bromfield, EB. Variation of Serum Valproate and Lamotrigine Levels in Relation to Menstrual Cycle Phase and Oral Contraceptive Use . Epilepsia. 2007; 48(s6):362.
  9. Shields DC, Costello DJ, Gale JT, Hoch DB, Eskandar EN. Stereotactic cortical resection in non-lesional extra-temporal partial epilepsy. Eur J Neurol. 2007 Oct; 14(10):1186-8. PMID: 17708755.
    Citations:    Fields:    Translation:Humans
  10. Costello, DJ; Hoch, DB, Chiappa, KH; Cosgrove, GR; COle, AJ. Surgery for epilepsy in the older patient-a plausible option. Epilepsia. 2005; 46(Supplement 8):239.
  11. Hoch D, Ferguson T. What I've learned from E-patients. PLoS Med. 2005 Aug; 2(8):e206. PMID: 16060721.
    Citations: 6     Fields:    Translation:Humans
  12. Eckstein O, Stemmer-Rachamimov A, Nunes F, Hoch D, Ojemann R, MacCollin M. Multiple meningiomas in brain and lung due to acquired mutation of the NF2 gene. Neurology. 2004 May 25; 62(10):1904-5. PMID: 15159511.
    Citations: 2     Fields:    Translation:HumansCells
  13. Lester J, Prady S, Finegan Y, Hoch D. Learning from e-patients at Massachusetts General Hospital. BMJ. 2004 May 15; 328(7449):1188-90. PMID: 15142930.
    Citations: 5     Fields:    Translation:Humans
  14. Doherty CP, Cole AJ, Grant PE, Fischman A, Dooling E, Hoch DB, White TH, Cosgrove GR. Multimodal longitudinal imaging of focal status epilepticus. Can J Neurol Sci. 2004 May; 31(2):276-81. PMID: 15198460.
    Citations: 6     Fields:    Translation:Humans
  15. Lester, John, BS, Prady, Stephanie, BSc, MAc, Finegan, Yolanda, BA, and Hoch, Daniel PhD, MD. How Online Patient Networks Can Enhance Quality and Reduce Errors. Patient Safety and Quality Healthcare. 2004; (October/December).
  16. Glenn MB, Hoch DB, Daly L. Anticonvulsants. J Head Trauma Rehabil. 2003 Jul-Aug; 18(4):383-6. PMID: 16222132.
    Citations:    Fields:    Translation:Humans
  17. Hoch, D.B.; Prady, S.; Finegan, Y.; Daly, L.; Lester, J. The Computer Human Interface as a Partner in the Doctor Patient Relationship. Proceedings of the HCI International 2003. 2003; 3:1001-1005.
  18. Prady S, Finegan Y, Lester J, Daly L, Hoch DB. An online communication tool alters the way patients find information. AMIA Annu Symp Proc. 2003; 976. PMID: 14728480.
    Citations:    Fields:    Translation:Humans
  19. Finegan,Y.N.; Daly,L.M.; Prady,S.L.; Hoch,D.B.; Lester,J.E. Large Websites Offer Explanations for the Difficulties that Epilepsy Patients Face, but Neglect Solutions Regarding Navigating "The Small Things". Epilepsia. 2003; 44(Suppl 9):183.
  20. Pohlmann-Eden B, Hennerici MG, Hoch DB. The relevance of poststroke seizures. Arch Neurol. 2002 Nov; 59(11):1831; author reply 1831-2. PMID: 12433274.
    Citations: 2     Fields:    Translation:Humans
  21. Hoch, DB; Prady, S; Lester, JE; Norris, D. Online communities become collaborators in research. Shaping the Network Society: Patterns for Participation, Action and Change. 2002.
  22. Doherty CP, Hoch D, Cole AJ. Surgery for temporal-lobe epilepsy. N Engl J Med. 2002 Jan 24; 346(4):292-5. PMID: 11811180.
    Citations:    Fields:    Translation:Humans
  23. Prady SL, Waruingi W, Norris D, Lester JE, Hoch DB. . User Feedback in the Development of an On-Line Communication Tool for Patients and Providers. Visions of the Future and Lessons from the Past. 2001.
  24. Prady SL, Norris D, Lester JE, Hoch DB. Expanding the guidelines for electronic communication with patients: application to a specific tool. J Am Med Inform Assoc. 2001 Jul-Aug; 8(4):344-8. PMID: 11418540.
    Citations: 7     Fields:    Translation:Humans
  25. Pohlmann-Eden,B; Hoch,DB; Strittmatter,EI; Schereiner,A; Henning,O. Seizures, epilepsy and ischemia- a mutual exciting relationship. Epilepsia. 2001; 42(Supplement 1):69.
  26. Prady,S.L.; Lester,J.; Norris,D.; Waruing, W.; Schneider,E.; Kelly,K.; Hoch,D.B. The use of a focus group to supplement the design of a Patient-Provider web resource. Abridged Proceedings of the 9th International Conference on Human-Computer Interaction. 2001.
  27. Joseph A. Capp and Daniel B. Hoch. Impact of an EMR on Communication between Tertiary and Primary Care Providers in a Neurology Teaching Clinic. Procedings of the International Medical Informatics Association. 2001.
  28. Dworetzky BA, Hoch DB, Wagner AK, Salmanson E, Shanahan CW, Bromfield EB. The impact of a single seizure on health status and health care utilization. Epilepsia. 2000 Feb; 41(2):170-6. PMID: 10691113.
    Citations:    Fields:    Translation:Humans
  29. Hoch DB, Norris D, Lester JE, Marcus AD. Information exchange in an epilepsy forum on the World Wide Web. Seizure. 1999 Feb; 8(1):30-4. PMID: 10091845.
    Citations: 8     Fields:    Translation:Humans
  30. Lester,J.E.; Norris,D.; Prady,S.L.; Hoch,D.B. Patient Support Using the World Wide Web. Webnet Conference, Hawaii. 1999.
  31. Pohlmann-Eden B, Mager RD, Hoch DB, Cochius JI. . The significance of subclinical epileptiform activity after stroke. Neurophysiology. Ed. Stalberg E, Deweerd AW, Zidor J. 1998; 523-532.
  32. Norris D.; Hoch D.; Lester J. An Internet forum for epilepsy support: a survey of users. Epilepsia. 1998; 39(Suppl 6):229.
  33. Pohlmann-Eden B, Cochius JI, Hoch DB, Hennerici M. . Stroke and epilepsy, II: risk factors, pathophysiology and overlap syndromes. Cerebrovasc Dis. 1997; 7:2-9.
  34. Hoch, D. B., Prady, S and Norris, D. PatientWeb library. 1997.
  35. Pohlmann-Eden B, Hoch DB, Cochius JI, Chiappa KH. Periodic lateralized epileptiform discharges--a critical review. J Clin Neurophysiol. 1996 Nov; 13(6):519-30. PMID: 8978624.
    Citations: 22     Fields:    Translation:Humans
  36. Hoch, D. B. Periodic Lateralized Epileptiform Discharges. 1996.
  37. Pohlmann-Eden B, Hoch DB, Cochius JI, Hennerici MG. . Stroke and epilepsy, I: epidemiology and risk factors. Cerebrovasc Dis. 1996; 6:332-338.
  38. Hoch DB, Hill RA, Oas KH. Epilepsy and mental decline. Neurol Clin. 1994 Feb; 12(1):101-13. PMID: 8183204.
    Citations: 1     Fields:    Translation:Humans
  39. Cloughesy TF, Nuwer MR, Hoch D, Vinuela F, Duckwiler G, Martin N. Monitoring carotid test occlusions with continuous EEG and clinical examination. J Clin Neurophysiol. 1993 Jul; 10(3):363-9. PMID: 8408601.
    Citations: 5     Fields:    Translation:Humans
  40. Hoch DB. Brain death: a diagnostic dilemma. J Nucl Med. 1992 Dec; 33(12):2211-3. PMID: 1460518.
    Citations: 1     Fields:    Translation:Humans
  41. Nuwer MR, Banoczi WR, Cloughesy TF, Hoch DB, Peacock W, Levesque MF, Black KL, Martin NA, Becker DP. Topographic mapping of somatosensory evoked potentials helps identify motor cortex more quickly in the operating room. Brain Topogr. 1992; 5(1):53-8. PMID: 1463660.
    Citations: 2     Fields:    Translation:Humans
  42. Geraghty JJ, Hoch DB, Robert ME, Vinters HV. Fatal puerperal cerebral vasospasm and stroke in a young woman. Neurology. 1991 Jul; 41(7):1145-7. PMID: 2067647.
    Citations: 13     Fields:    Translation:Humans
  43. Berry BW, Boland LM, Hoch DB, Dingledine R. L-glutamate binding site on N18-RE-105 neuroblastoma hybrid cells is not coupled to an ion channel. J Neurochem. 1988 Oct; 51(4):1176-83. PMID: 2458433.
    Citations:    Fields:    Translation:AnimalsCells
  44. Hoch DB, Dingledine R. GABAergic neurons in rat hippocampal culture. Brain Res. 1986 Feb; 390(1):53-64. PMID: 3512041.
    Citations: 5     Fields:    Translation:AnimalsCells
  45. Hoch DB, Wilson JE, Dingledine RJ. Factors affecting the phosphorylation of a 41,000 dalton protein of hippocampal subcellular fractions. Brain Res. 1984 Jun 04; 302(1):117-24. PMID: 6733499.
    Citations:    Fields:    Translation:AnimalsCells
  46. Hoch DB, Dingledine RJ, Wilson JE. Long-term potentiation in the hippocampal slice: possible involvement of pyruvate dehydrogenase. Brain Res. 1984 Jun 04; 302(1):125-34. PMID: 6733500.
    Citations:    Fields:    Translation:AnimalsCells
  47. Hoch DB, Wilson JE. Effects of calcium, strontium, and barium ions on phosphorylation of hippocampal proteins in vitro. J Neurochem. 1984 Jan; 42(1):54-8. PMID: 6689699.
    Citations: 2     Fields:    Translation:AnimalsCells
  48. Hoch, D.B. Hippocampal Long-term Potentiation and Protein Phosphorylation. 1982.
  49. Myers RD, Hoch DB. Localization of sites in the brain mediating alcohol drinking induced by tetrahydropapaveroline (THP). Curr Alcohol. 1979; 5:29-44. PMID: 755629.
    Citations:    Fields:    Translation:Animals
  50. Hoch, D. B. . Localization of Sites in the Brain Mediating Alcohol Drinking Induced by Tetrahydropapaveroline. 1979.
  51. Myers RD, Hoch DB. 14C-dopamine microinjected into the brain-stem of the rat: dispersion kinetics, site content and functional dose. Brain Res Bull. 1978 Nov-Dec; 3(6):601-9. PMID: 318183.
    Citations: 17     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.