Harvard Catalyst Profiles

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Daniel Jean-Francois Chinnapen, D.PHIL.

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  1. R01DK104868 (LENCER, WAYNE I) Jul 4, 2016 - Jun 30, 2020
    NIH/NIDDK
    Harnessing the biology of glycosphingolipid trafficking for biologic drug delivery
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Garcia-Castillo MD, Lencer WI, Chinnapen DJ. Transcytosis Assay for Transport of Glycosphingolipids across MDCK-II Cells. Bio Protoc. 2018 Oct 20; 8(20). PMID: 30505885.
    Citations:    
  2. Garcia-Castillo MD, Chinnapen DJ, Te Welscher YM, Gonzalez RJ, Softic S, Pacheco M, Mrsny RJ, Kahn CR, von Andrian UH, Lau J, Pentelute BL, Lencer WI. Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids. Elife. 2018 05 31; 7. PMID: 29851380.
    Citations:    Fields:    
  3. Cho JA, Chinnapen DJF. Targeting friend and foe: Emerging therapeutics in the age of gut microbiome and disease. J Microbiol. 2018 Mar; 56(3):183-188. PMID: 29492875.
    Citations: 1     Fields:    Translation:Humans
  4. Garcia-Castillo MD, Chinnapen DJ, Lencer WI. Membrane Transport across Polarized Epithelia. Cold Spring Harb Perspect Biol. 2017 Sep 01; 9(9). PMID: 28213463.
    Citations: 2     Fields:    Translation:HumansCells
  5. Raghunathan K, Wong TH, Chinnapen DJ, Lencer WI, Jobling MG, Kenworthy AK. Glycolipid Crosslinking Is Required for Cholera Toxin to Partition Into and Stabilize Ordered Domains. Biophys J. 2016 Dec 20; 111(12):2547-2550. PMID: 27914621.
    Citations: 2     Fields:    Translation:AnimalsCells
  6. Day CA, Baetz NW, Copeland CA, Kraft LJ, Han B, Tiwari A, Drake KR, De Luca H, Chinnapen DJ, Davidson MW, Holmes RK, Jobling MG, Schroer TA, Lencer WI, Kenworthy AK. Microtubule motors power plasma membrane tubulation in clathrin-independent endocytosis. Traffic. 2015 Jun; 16(6):572-90. PMID: 25690058.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  7. te Welscher YM, Chinnapen DJ, Kaoutzani L, Mrsny RJ, Lencer WI. Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1. J Control Release. 2014 Feb 10; 175:72-8. PMID: 24370893.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Saslowsky DE, te Welscher YM, Chinnapen DJ, Wagner JS, Wan J, Kern E, Lencer WI. Ganglioside GM1-mediated transcytosis of cholera toxin bypasses the retrograde pathway and depends on the structure of the ceramide domain. J Biol Chem. 2013 Sep 06; 288(36):25804-9. PMID: 23884419.
    Citations: 10     Fields:    Translation:AnimalsCells
  9. Chinnapen DJ, Hsieh WT, te Welscher YM, Saslowsky DE, Kaoutzani L, Brandsma E, D'Auria L, Park H, Wagner JS, Drake KR, Kang M, Benjamin T, Ullman MD, Costello CE, Kenworthy AK, Baumgart T, Massol RH, Lencer WI. Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1. Dev Cell. 2012 Sep 11; 23(3):573-86. PMID: 22975326.
    Citations: 33     Fields:    Translation:HumansCells
  10. Cho JA, Chinnapen DJ, Aamar E, te Welscher YM, Lencer WI, Massol R. Insights on the trafficking and retro-translocation of glycosphingolipid-binding bacterial toxins. Front Cell Infect Microbiol. 2012; 2:51. PMID: 22919642.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  11. Janz JM, Ren Y, Looby R, Kazmi MA, Sachdev P, Grunbeck A, Haggis L, Chinnapen D, Lin AY, Seibert C, McMurry T, Carlson KE, Muir TW, Hunt S, Sakmar TP. Direct interaction between an allosteric agonist pepducin and the chemokine receptor CXCR4. J Am Chem Soc. 2011 Oct 12; 133(40):15878-81. PMID: 21905700.
    Citations: 22     Fields:    Translation:HumansCells
  12. Fortin JP, Chinnapen D, Beinborn M, Lencer W, Kopin AS. Discovery of dual-action membrane-anchored modulators of incretin receptors. PLoS One. 2011; 6(9):e24693. PMID: 21935440.
    Citations: 10     Fields:    Translation:HumansCells
  13. Uchida Y, Hasegawa J, Chinnapen D, Inoue T, Okazaki S, Kato R, Wakatsuki S, Misaki R, Koike M, Uchiyama Y, Iemura S, Natsume T, Kuwahara R, Nakagawa T, Nishikawa K, Mukai K, Miyoshi E, Taniguchi N, Sheff D, Lencer WI, Taguchi T, Arai H. Intracellular phosphatidylserine is essential for retrograde membrane traffic through endosomes. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15846-51. PMID: 21911378.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  14. Saslowsky DE, Cho JA, Chinnapen H, Massol RH, Chinnapen DJ, Wagner JS, De Luca HE, Kam W, Paw BH, Lencer WI. Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2. J Clin Invest. 2010 Dec; 120(12):4399-4409. PMID: 21041954.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  15. Wernick NL, Chinnapen DJ, Cho JA, Lencer WI. Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum. Toxins (Basel). 2010 03; 2(3):310-25. PMID: 22069586.
    Citations: 51     Fields:    Translation:HumansCells
  16. N.B. Wernick, D. J.-F. Chinnapen, J.A. Cho and W.I. Lencer. Toxins. Cholera Toxin: An Intracellular Journey into the Cytosol by Way of the Endoplasmic Reticulum. 2010; 3:310-325.
  17. Thorne RE, Chinnapen DJ, Sekhon GS, Sen D. A deoxyribozyme, Sero1C, uses light and serotonin to repair diverse pyrimidine dimers in DNA. J Mol Biol. 2009 Apr 24; 388(1):21-9. PMID: 19281822.
    Citations: 4     Fields:    Translation:Cells
  18. Chinnapen DJ, Chinnapen H, Saslowsky D, Lencer WI. Rafting with cholera toxin: endocytosis and trafficking from plasma membrane to ER. FEMS Microbiol Lett. 2007 Jan; 266(2):129-37. PMID: 17156122.
    Citations: 70     Fields:    Translation:HumansAnimalsCells
  19. Chinnapen DJ, Sen D. Towards elucidation of the mechanism of UV1C, a deoxyribozyme with photolyase activity. J Mol Biol. 2007 Feb 02; 365(5):1326-36. PMID: 17141270.
    Citations: 2     Fields:    Translation:Cells
  20. Howarth M, Chinnapen DJ, Gerrow K, Dorrestein PC, Grandy MR, Kelleher NL, El-Husseini A, Ting AY. A monovalent streptavidin with a single femtomolar biotin binding site. Nat Methods. 2006 Apr; 3(4):267-73. PMID: 16554831.
    Citations: 97     Fields:    Translation:AnimalsCells
  21. H.-W. Lee, D.J.-F. Chinnapen and D. Sen. Pure and Applied Chemistry. Structure-Function Investigation of a Deoxyribozyme with Dual Chelatase and Peroxidase Activities. 2004; 76:1537-1545.
  22. Chinnapen DJ, Sen D. A deoxyribozyme that harnesses light to repair thymine dimers in DNA. Proc Natl Acad Sci U S A. 2004 Jan 06; 101(1):65-9. PMID: 14691255.
    Citations: 22     Fields:    Translation:Cells
  23. Sen D, Chinnapen DJ. Deoxyribozymes that catalyze photochemistry: cofactor-dependent and -independent photorepair of thymine dimers. Nucleic Acids Res Suppl. 2003; (3):217-8. PMID: 14510458.
    Citations:    Fields:    Translation:Cells
  24. Chinnapen DJ, Sen D. Hemin-stimulated docking of cytochrome c to a hemin-DNA aptamer complex. Biochemistry. 2002 Apr 23; 41(16):5202-12. PMID: 11955069.
    Citations: 2     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.