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profileOvidiu C Andronesi, Ph.D., M.D.

TitleAssistant Professor of Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital
Radiology, Rm 2301
149 13th Street
Charlestown MA 02129
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01CA211080     (ANDRONESI, OVIDIU C)Feb 1, 2017 - Jan 31, 2022
NIH/NCI
Development of whole-brain in vivo 2HG imaging for precision medicine in mutant IDH glioma
Role: Principal Investigator

K22CA178269     (ANDRONESI, OVIDIU C)Jul 8, 2013 - Nov 30, 2016
NIH/NCI
Quantify treatment response in IDH1 mutant glioma patients with metabolic MRI
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Bogner W, Hangel G, Esmaeili M, Andronesi OC. 1D-spectral editing and 2D multispectral in vivo1H-MRS and 1H-MRSI - Methods and applications. Anal Biochem. 2017 Jul 15; 529:48-64. PMID: 28034791.
    View in: PubMed
  2. Valkovic L, Chmelík M, Meyerspeer M, Gagoski B, Rodgers CT, Krššák M, Andronesi OC, Trattnig S, Bogner W. Dynamic 31 P-MRSI using spiral spectroscopic imaging can map mitochondrial capacity in muscles of the human calf during plantar flexion exercise at 7 T. NMR Biomed. 2016 Dec; 29(12):1825-1834. PMID: 27862510.
    View in: PubMed
  3. Hnilicová P, Považan M, Strasser B, Andronesi OC, Gajdošík M, Dydak U, Ukropec J, Dobrota D, Trattnig S, Bogner W. Spatial variability and reproducibility of GABA-edited MEGA-LASER 3D-MRSI in the brain at 3 T. NMR Biomed. 2016 Nov; 29(11):1656-1665. PMID: 27717093.
    View in: PubMed
  4. Jafari-Khouzani K, Loebel F, Bogner W, Rapalino O, Gonzalez GR, Gerstner E, Chi AS, Batchelor TT, Rosen BR, Unkelbach J, Shih HA, Cahill DP, Andronesi OC. Volumetric relationship between 2-hydroxyglutarate and FLAIR hyperintensity has potential implications for radiotherapy planning of mutant IDH glioma patients. Neuro Oncol. 2016 Nov; 18(11):1569-1578. PMID: 27382115.
    View in: PubMed
  5. Esmaeili M, Bathen TF, Rosen BR, Andronesi OC. Three-dimensional MR spectroscopic imaging using adiabatic spin echo and hypergeometric dual-band suppression for metabolic mapping over the entire brain. Magn Reson Med. 2017 Feb; 77(2):490-497. PMID: 26840906.
    View in: PubMed
  6. Andronesi OC, Loebel F, Bogner W, Marjanska M, Vander Heiden MG, Iafrate AJ, Dietrich J, Batchelor TT, Gerstner ER, Kaelin WG, Chi AS, Rosen BR, Cahill DP. Treatment Response Assessment in IDH-Mutant Glioma Patients by Noninvasive 3D Functional Spectroscopic Mapping of 2-Hydroxyglutarate. Clin Cancer Res. 2016 Apr 01; 22(7):1632-41. PMID: 26534967; PMCID: PMC4818725 [Available on 04/01/17].
  7. Schirda CV, Zhao T, Andronesi OC, Lee Y, Pan JW, Mountz JM, Hetherington HP, Boada FE. In vivo brain rosette spectroscopic imaging (RSI) with LASER excitation, constant gradient strength readout, and automated LCModel quantification for all voxels. Magn Reson Med. 2016 Aug; 76(2):380-90. PMID: 26308482.
    View in: PubMed
  8. Bogner W, Gagoski B, Hess AT, Bhat H, Tisdall MD, van der Kouwe AJ, Strasser B, Marjanska M, Trattnig S, Grant E, Rosen B, Andronesi OC. 3D GABA imaging with real-time motion correction, shim update and reacquisition of adiabatic spiral MRSI. Neuroimage. 2014 Dec; 103:290-302. PMID: 25255945; PMCID: PMC4312209.
  9. Kalpathy-Cramer J, Gerstner ER, Emblem KE, Andronesi O, Rosen B. Advanced magnetic resonance imaging of the physical processes in human glioblastoma. Cancer Res. 2014 Sep 01; 74(17):4622-4637. PMID: 25183787; PMCID: PMC4155518.
  10. Loebel F, Cahill DP, Bogner W, Marjanska M, Gerstner E, Batchelor T, Rosen BR, Chi AS, Andronesi OC. Sherry apple resident travel scholarship 194 assessment of treatment response in isocitrate dehydrogenase-mutant gliomas by quantification of 2-hydroxyglutarate with in vivo 3-dimensional magnetic resonance spectroscopy. Neurosurgery. 2014 Aug; 61 Suppl 1:224. PMID: 25032645.
    View in: PubMed
  11. Andronesi OC, Bhat H, Reuter M, Mukherjee S, Caravan P, Rosen BR. Whole brain mapping of water pools and molecular dynamics with rotating frame MR relaxation using gradient modulated low-power adiabatic pulses. Neuroimage. 2014 Apr 01; 89:92-109. PMID: 24345390; PMCID: PMC3944112.
  12. Bogner W, Hess AT, Gagoski B, Tisdall MD, van der Kouwe AJ, Trattnig S, Rosen B, Andronesi OC. Real-time motion- and B0-correction for LASER-localized spiral-accelerated 3D-MRSI of the brain at 3T. Neuroimage. 2014 Mar; 88:22-31. PMID: 24201013; PMCID: PMC4010560.
  13. Eichner C, Jafari-Khouzani K, Cauley S, Bhat H, Polaskova P, Andronesi OC, Rapalino O, Turner R, Wald LL, Stufflebeam S, Setsompop K. Slice accelerated gradient-echo spin-echo dynamic susceptibility contrast imaging with blipped CAIPI for increased slice coverage. Magn Reson Med. 2014 Sep; 72(3):770-8. PMID: 24285593; PMCID: PMC4002660.
  14. Andronesi OC, Rapalino O, Gerstner E, Chi A, Batchelor TT, Cahill DP, Sorensen AG, Rosen BR. Detection of oncogenic IDH1 mutations using magnetic resonance spectroscopy of 2-hydroxyglutarate. J Clin Invest. 2013 Sep; 123(9):3659-63. PMID: 23999439; PMCID: PMC3754248.
  15. Yuan Y, Andronesi OC, Bortfeld TR, Richter C, Wolf R, Guimaraes AR, Hong TS, Seco J. Feasibility study of in vivo MRI based dosimetric verification of proton end-of-range for liver cancer patients. Radiother Oncol. 2013 Mar; 106(3):378-82. PMID: 23473960.
    View in: PubMed
  16. Dunn GP, Andronesi OC, Cahill DP. From genomics to the clinic: biological and translational insights of mutant IDH1/2 in glioma. Neurosurg Focus. 2013 Feb; 34(2):E2. PMID: 23373447.
    View in: PubMed
  17. Metsis V, Huang H, Andronesi OC, Makedon F, Tzika A. Heterogeneous data fusion for brain tumor classification. Oncol Rep. 2012 Oct; 28(4):1413-6. PMID: 22842996.
    View in: PubMed
  18. Andronesi OC, Kim GS, Gerstner E, Batchelor T, Tzika AA, Fantin VR, Vander Heiden MG, Sorensen AG. Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy. Sci Transl Med. 2012 Jan 11; 4(116):116ra4. PMID: 22238332; PMCID: PMC3720836.
  19. Andronesi OC, Gagoski BA, Sorensen AG. Neurologic 3D MR spectroscopic imaging with low-power adiabatic pulses and fast spiral acquisition. Radiology. 2012 Feb; 262(2):647-61. PMID: 22187628; PMCID: PMC3267083.
  20. Hess AT, Andronesi OC, Tisdall MD, Sorensen AG, van der Kouwe AJ, Meintjes EM. Real-time motion and B0 correction for localized adiabatic selective refocusing (LASER) MRSI using echo planar imaging volumetric navigators. NMR Biomed. 2012 Feb; 25(2):347-58. PMID: 21796711; PMCID: PMC3261340.
  21. Andronesi OC, Gagoski BA, Adalsteinsson E, Sorensen AG. Correlation chemical shift imaging with low-power adiabatic pulses and constant-density spiral trajectories. NMR Biomed. 2012 Feb; 25(2):195-209. PMID: 21774010; PMCID: PMC3261335.
  22. Kim H, Catana C, Ratai EM, Andronesi OC, Jennings DL, Batchelor TT, Jain RK, Sorensen AG. Serial magnetic resonance spectroscopy reveals a direct metabolic effect of cediranib in glioblastoma. Cancer Res. 2011 Jun 01; 71(11):3745-52. PMID: 21507932; PMCID: PMC3107375.
  23. Bogner W, Chmelik M, Andronesi OC, Sorensen AG, Trattnig S, Gruber S. In vivo 31P spectroscopy by fully adiabatic extended image selected in vivo spectroscopy: a comparison between 3 T and 7 T. Magn Reson Med. 2011 Oct; 66(4):923-30. PMID: 21446033.
    View in: PubMed
  24. Hess AT, Tisdall MD, Andronesi OC, Meintjes EM, van der Kouwe AJ. Real-time motion and B0 corrected single voxel spectroscopy using volumetric navigators. Magn Reson Med. 2011 Aug; 66(2):314-23. PMID: 21381101; PMCID: PMC3123687.
  25. Ramadan S, Andronesi OC, Stanwell P, Lin AP, Sorensen AG, Mountford CE. Use of in vivo two-dimensional MR spectroscopy to compare the biochemistry of the human brain to that of glioblastoma. Radiology. 2011 May; 259(2):540-9. PMID: 21357517; PMCID: PMC3079117.
  26. Astrakas L, Blekas KD, Constantinou C, Andronesi OC, Mindrinos MN, Likas AC, Rahme LG, Black PM, Marcus KJ, Tzika AA. Combining magnetic resonance spectroscopy and molecular genomics offers better accuracy in brain tumor typing and prediction of survival than either methodology alone. Int J Oncol. 2011 Apr; 38(4):1113-27. PMID: 21274507.
    View in: PubMed
  27. di Tomaso E, Snuderl M, Kamoun WS, Duda DG, Auluck PK, Fazlollahi L, Andronesi OC, Frosch MP, Wen PY, Plotkin SR, Hedley-Whyte ET, Sorensen AG, Batchelor TT, Jain RK. Glioblastoma recurrence after cediranib therapy in patients: lack of "rebound" revascularization as mode of escape. Cancer Res. 2011 Jan 01; 71(1):19-28. PMID: 21199795; PMCID: PMC3074948.
  28. Andronesi OC, Mintzopoulos D, Righi V, Psychogios N, Kesarwani M, He J, Yasuhara S, Dai G, Rahme LG, Tzika AA. Combined off-resonance imaging and T2 relaxation in the rotating frame for positive contrast MR imaging of infection in a murine burn model. J Magn Reson Imaging. 2010 Nov; 32(5):1172-83. PMID: 21031524; PMCID: PMC2975424.
  29. Andronesi OC, Ramadan S, Mountford CE, Sorensen AG. Low-power adiabatic sequences for in vivo localized two-dimensional chemical shift correlated MR spectroscopy. Magn Reson Med. 2010 Dec; 64(6):1542-56. PMID: 20890988; PMCID: PMC3214589.
  30. Righi V, Andronesi OC, Mintzopoulos D, Black PM, Tzika AA. High-resolution magic angle spinning magnetic resonance spectroscopy detects glycine as a biomarker in brain tumors. Int J Oncol. 2010 Feb; 36(2):301-6. PMID: 20043062; PMCID: PMC3715372.
  31. Andronesi OC, Ramadan S, Ratai EM, Jennings D, Mountford CE, Sorensen AG. Spectroscopic imaging with improved gradient modulated constant adiabaticity pulses on high-field clinical scanners. J Magn Reson. 2010 Apr; 203(2):283-93. PMID: 20163975; PMCID: PMC3214007.
  32. Righi V, Andronesi O, Mintzopoulos D, Tzika AA. Molecular characterization and quantification using state of the art solid-state adiabatic TOBSY NMR in burn trauma. Int J Mol Med. 2009 Dec; 24(6):749-57. PMID: 19885614; PMCID: PMC3722686.
  33. Sorensen AG, Jenning D, Wang M, Andronesi O, Chen P, Prados M, Wen P, Jackson E, Cha S, deGroot J. Use of neurovascular imaging in GBM patients (pts) to quantify early physiologic changes after treatment with XL184, an inhibitor of multiple receptor tyrosine kinases: Results from a phase II study. J Clin Oncol. 2009 May 20; 27(15_suppl):2048. PMID: 27964638.
    View in: PubMed
  34. Andronesi OC, Blekas KD, Mintzopoulos D, Astrakas L, Black PM, Tzika AA. Molecular classification of brain tumor biopsies using solid-state magic angle spinning proton magnetic resonance spectroscopy and robust classifiers. Int J Oncol. 2008 Nov; 33(5):1017-25. PMID: 18949365; PMCID: PMC2658602.
  35. Andronesi OC, Mintzopoulos D, Struppe J, Black PM, Tzika AA. Solid-state NMR adiabatic TOBSY sequences provide enhanced sensitivity for multidimensional high-resolution magic-angle-spinning 1H MR spectroscopy. J Magn Reson. 2008 Aug; 193(2):251-8. PMID: 18556227.
    View in: PubMed
  36. Andronesi OC, von Bergen M, Biernat J, Seidel K, Griesinger C, Mandelkow E, Baldus M. Characterization of Alzheimer's-like paired helical filaments from the core domain of tau protein using solid-state NMR spectroscopy. J Am Chem Soc. 2008 May 07; 130(18):5922-8. PMID: 18386894.
    View in: PubMed
  37. Seidel K, Andronesi OC, Krebs J, Griesinger C, Young HS, Becker S, Baldus M. Structural characterization of Ca(2+)-ATPase-bound phospholamban in lipid bilayers by solid-state nuclear magnetic resonance (NMR) spectroscopy. Biochemistry. 2008 Apr 15; 47(15):4369-76. PMID: 18355039.
    View in: PubMed
  38. Tzika AA, Astrakas L, Cao H, Mintzopoulos D, Andronesi OC, Mindrinos M, Zhang J, Rahme LG, Blekas KD, Likas AC, Galatsanos NP, Carroll RS, Black PM. Combination of high-resolution magic angle spinning proton magnetic resonance spectroscopy and microscale genomics to type brain tumor biopsies. Int J Mol Med. 2007 Aug; 20(2):199-208. PMID: 17611638.
    View in: PubMed
  39. Etzkorn M, Martell S, Andronesi OC, Seidel K, Engelhard M, Baldus M. Secondary structure, dynamics, and topology of a seven-helix receptor in native membranes, studied by solid-state NMR spectroscopy. Angew Chem Int Ed Engl. 2007; 46(3):459-62. PMID: 17001715.
    View in: PubMed
  40. Hughes CE, Olejniczak S, Helinski J, Ciesielski W, Repisky M, Andronesi OC, Potrzebowski MJ, Baldus M. Probing structure in the polymorphic domain of the L-enantiomer of N-benzoyl-phenylalanine by means of 2D solid-state NMR spectroscopy and DFT calculations. J Phys Chem B. 2005 Dec 15; 109(49):23175-82. PMID: 16375280.
    View in: PubMed
  41. Heise H, Hoyer W, Becker S, Andronesi OC, Riedel D, Baldus M. Molecular-level secondary structure, polymorphism, and dynamics of full-length alpha-synuclein fibrils studied by solid-state NMR. Proc Natl Acad Sci U S A. 2005 Nov 01; 102(44):15871-6. PMID: 16247008; PMCID: PMC1276071.
  42. Andronesi OC, Becker S, Seidel K, Heise H, Young HS, Baldus M. Determination of membrane protein structure and dynamics by magic-angle-spinning solid-state NMR spectroscopy. J Am Chem Soc. 2005 Sep 21; 127(37):12965-74. PMID: 16159291.
    View in: PubMed
  43. Andronesi OC, Pfeifer JR, Al-Momani L, Ozdirekcan S, Rijkers DT, Angerstein B, Luca S, Koert U, Killian JA, Baldus M. Probing membrane protein orientation and structure using fast magic-angle-spinning solid-state NMR. J Biomol NMR. 2004 Nov; 30(3):253-65. PMID: 15754053.
    View in: PubMed
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