Harvard Catalyst Profiles

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Frederick M. Ausubel

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Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R43DK127754 (AUSUBEL, FREDERICK M) Jul 1, 2021 - Jun 30, 2022
    NIH
    First-in-class small molecule therapeutics to enhance gut barrier function in inflammatory bowel disease
    Role: Principal Investigator
  2. R43HL156593 (AUSUBEL, FREDERICK M) Jul 1, 2021 - Dec 31, 2021
    NIH
    First-in-class small molecules that enhance lung barrier function during acute respiratory distress syndrome (ARDS) as potential therapeutics for COVID-19
    Role: Principal Investigator
  3. R43AR072556 (AUSUBEL, FREDERICK M) Aug 1, 2017 - Apr 30, 2018
    NIH
    Discovering Novel Therapeutics for Myotonic Dystrophy Type 1 (DM1)
    Role: Principal Investigator
  4. R01AI085581 (AUSUBEL, FREDERICK M) Sep 28, 2009 - Aug 31, 2015
    NIH
    Identifying novel anti-infectives by high through-put screening in whole animals
    Role: Principal Investigator
  5. P01AI083214 (GILMORE, MICHAEL S) Sep 1, 2009 - Aug 31, 2021
    NIH
    Harvard-wide Program on Antibiotic Resistance
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Sella Y, Broderick NA, Stouffer K, McEwan DL, Ausubel FM, Casadevall A, Bergman A. Chaotic signatures in host-microbe interactions. bioRxiv. 2022 Dec 14. PMID: 36561184; PMCID: PMC9774220.
    Citations:    
  2. Kim SM, Zou G, Kim H, Kang M, Ahn S, Heo HY, Kim JS, Lim KM, Ausubel FM, Mylonakis E, Gao H, Kim W. Antimicrobial activity of the membrane-active compound nTZDpa is enhanced at low pH. Biomed Pharmacother. 2022 Jun; 150:112977. PMID: 35447554.
    Citations: 3     Fields:    Translation:HumansCells
  3. Vasquez-Rifo A, Cook J, McEwan DL, Shikara D, Ausubel FM, Di Cara F, Cheng Z. ABCDs of the Relative Contributions of Pseudomonas aeruginosa Quorum Sensing Systems to Virulence in Diverse Nonvertebrate Hosts. mBio. 2022 04 26; 13(2):e0041722. PMID: 35311532; PMCID: PMC9040828.
    Citations:    Fields:    Translation:AnimalsCells
  4. Xie F, Dai S, Zhao Y, Huang P, Yu S, Ren B, Wang Q, Ji Z, Alterovitz G, Zhang Q, Zhang J, Chen X, Jiang L, Song F, Liu H, Ausubel FM, Liu X, Dai H, Zhang L. Generation of Fluorinated Amychelin Siderophores against Pseudomonas aeruginosa Infections by a Combination of Genome Mining and Mutasynthesis. Cell Chem Biol. 2020 12 17; 27(12):1532-1543.e6. PMID: 33186541.
    Citations: 2     Fields:    Translation:AnimalsCells
  5. Lee K, Escobar I, Jang Y, Kim W, Ausubel FM, Mylonakis E. In the Model Host Caenorhabditis elegans, Sphingosine-1-Phosphate-Mediated Signaling Increases Immunity toward Human Opportunistic Bacteria. Int J Mol Sci. 2020 Oct 22; 21(21). PMID: 33105563.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  6. Khader R, Tharmalingam N, Mishra B, Felix L, Ausubel FM, Kelso MJ, Mylonakis E. Characterization of Five Novel Anti-MRSA Compounds Identified Using a Whole-Animal Caenorhabditis elegans/Galleria mellonella Sequential-Screening Approach. Antibiotics (Basel). 2020 Jul 27; 9(8). PMID: 32726955; PMCID: PMC7459823.
    Citations: 3     
  7. Kim W, Zou G, Pan W, Fricke N, Faizi HA, Kim SM, Khader R, Li S, Lee K, Escorba I, Vlahovska PM, Gao H, Ausubel FM, Mylonakis E. The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus. mBio. 2020 06 30; 11(3). PMID: 32605985.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  8. Vasquez-Rifo A, Veksler-Lublinsky I, Cheng Z, Ausubel FM, Ambros V. The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans. Genome Biol. 2019 12 10; 20(1):270. PMID: 31823826; PMCID: PMC6902481.
    Citations: 13     Fields:    Translation:AnimalsCells
  9. Kim W, Zou G, Hari TPA, Wilt IK, Zhu W, Galle N, Faizi HA, Hendricks GL, Tori K, Pan W, Huang X, Steele AD, Csatary EE, Dekarske MM, Rosen JL, Ribeiro NQ, Lee K, Port J, Fuchs BB, Vlahovska PM, Wuest WM, Gao H, Ausubel FM, Mylonakis E. A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16529-16534. PMID: 31358625; PMCID: PMC6697817.
    Citations: 46     Fields:    Translation:AnimalsCells
  10. Yuen GJ, Ausubel FM. Both live and dead Enterococci activate Caenorhabditis elegans host defense via immune and stress pathways. Virulence. 2018 12 31; 9(1):683-699. PMID: 29436902.
    Citations: 31     Fields:    Translation:AnimalsCells
  11. Ausubel FM. Tracing My Roots: How I Became a Plant Biologist. Annu Rev Genet. 2018 11 23; 52:1-20. PMID: 30192637.
    Citations:    Fields:    Translation:AnimalsCells
  12. Kim W, Steele AD, Zhu W, Csatary EE, Fricke N, Dekarske MM, Jayamani E, Pan W, Kwon B, Sinitsa IF, Rosen JL, Conery AL, Fuchs BB, Vlahovska PM, Ausubel FM, Gao H, Wuest WM, Mylonakis E. Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters. ACS Infect Dis. 2018 11 09; 4(11):1540-1545. PMID: 30132650; PMCID: PMC6468991.
    Citations: 19     Fields:    Translation:HumansCells
  13. Drenkard E, Hibbler RM, Gutu DA, Eaton AD, Silverio AL, Ausubel FM, Hurley BP, Yonker LM. Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants. J Vis Exp. 2018 05 04; (135). PMID: 29781996.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  14. Slatko BE, Gardner AF, Ausubel FM. Overview of Next-Generation Sequencing Technologies. Curr Protoc Mol Biol. 2018 04; 122(1):e59. PMID: 29851291.
    Citations: 163     Fields:    Translation:Humans
  15. Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N, Conery AL, Shen S, Pan W, Lee K, Rajamuthiah R, Fuchs BB, Vlahovska PM, Wuest WM, Gilmore MS, Gao H, Ausubel FM, Mylonakis E. A new class of synthetic retinoid antibiotics effective against bacterial persisters. Nature. 2018 04 05; 556(7699):103-107. PMID: 29590091.
    Citations: 114     Fields:    Translation:HumansAnimalsCells
  16. Haller S, Franchet A, Hakkim A, Chen J, Drenkard E, Yu S, Schirmeier S, Li Z, Martins N, Ausubel FM, Liégeois S, Ferrandon D. Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization. EMBO Rep. 2018 05; 19(5). PMID: 29523648; PMCID: PMC5934776.
    Citations: 8     Fields:    Translation:AnimalsCells
  17. Haney CH, Wiesmann CL, Shapiro LR, Melnyk RA, O'Sullivan LR, Khorasani S, Xiao L, Han J, Bush J, Carrillo J, Pierce NE, Ausubel FM. Rhizosphere-associated Pseudomonas induce systemic resistance to herbivores at the cost of susceptibility to bacterial pathogens. Mol Ecol. 2018 04; 27(8):1833-1847. PMID: 29087012.
    Citations: 16     Fields:    Translation:AnimalsCells
  18. Koeva M, Gutu AD, Hebert W, Wager JD, Yonker LM, O'Toole GA, Ausubel FM, Moskowitz SM, Joseph-McCarthy D. An Antipersister Strategy for Treatment of Chronic Pseudomonas aeruginosa Infections. Antimicrob Agents Chemother. 2017 12; 61(12). PMID: 28923873; PMCID: PMC5700368.
    Citations: 17     Fields:    Translation:HumansCells
  19. Cezairliyan B, Ausubel FM. Investment in secreted enzymes during nutrient-limited growth is utility dependent. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7796-E7802. PMID: 28847943; PMCID: PMC5604031.
    Citations: 15     Fields:    Translation:Cells
  20. Jayamani E, Tharmalingam N, Rajamuthiah R, Coleman JJ, Kim W, Okoli I, Hernandez AM, Lee K, Nau GJ, Ausubel FM, Mylonakis E. Characterization of a Francisella tularensis-Caenorhabditis elegans Pathosystem for the Evaluation of Therapeutic Compounds. Antimicrob Agents Chemother. 2017 09; 61(9). PMID: 28652232; PMCID: PMC5571314.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  21. Urbach JM, Ausubel FM. The NBS-LRR architectures of plant R-proteins and metazoan NLRs evolved in independent events. Proc Natl Acad Sci U S A. 2017 Jan 31; 114(5):1063-1068. PMID: 28096345; PMCID: PMC5293065.
    Citations: 46     Fields:    Translation:AnimalsCells
  22. Gregory KE, Samuel BS, Houghteling P, Shan G, Ausubel FM, Sadreyev RI, Walker WA. Influence of maternal breast milk ingestion on acquisition of the intestinal microbiome in preterm infants. Microbiome. 2016 12 30; 4(1):68. PMID: 28034306.
    Citations: 77     Fields:    Translation:HumansCells
  23. McEwan DL, Feinbaum RL, Stroustrup N, Haas W, Conery AL, Anselmo A, Sadreyev R, Ausubel FM. Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway. BMC Biol. 2016 12 07; 14(1):105. PMID: 27927200; PMCID: PMC5143455.
    Citations: 15     Fields:    Translation:AnimalsCells
  24. Newman M, Ausubel FM. Introduction to Gene Editing and Manipulation Using CRISPR/Cas9 Technology. Curr Protoc Mol Biol. 2016 07 01; 115:31.4.1-31.4.6. PMID: 27366890.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  25. Liu S, Bartnikas LM, Volko SM, Ausubel FM, Tang D. Mutation of the Glucosinolate Biosynthesis Enzyme Cytochrome P450 83A1 Monooxygenase Increases Camalexin Accumulation and Powdery Mildew Resistance. Front Plant Sci. 2016; 7:227. PMID: 26973671; PMCID: PMC4774424.
    Citations: 9     
  26. Kim W, Fricke N, Conery AL, Fuchs BB, Rajamuthiah R, Jayamani E, Vlahovska PM, Ausubel FM, Mylonakis E. NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption. Future Med Chem. 2016; 8(3):257-69. PMID: 26910612.
    Citations: 14     Fields:    Translation:Cells
  27. Cervone F, Ausubel FM, De Lorenzo G. Enhancing immunity by engineering DAMPs. Oncotarget. 2015 Oct 06; 6(30):28523-4. PMID: 26387132.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  28. Rajamuthiah R, Jayamani E, Majed H, Conery AL, Kim W, Kwon B, Fuchs BB, Kelso MJ, Ausubel FM, Mylonakis E. Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile. Bioorg Med Chem Lett. 2015 Nov 15; 25(22):5203-7. PMID: 26459212; PMCID: PMC4718707.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  29. Haney CH, Ausubel FM. MICROBIOME. Plant microbiome blueprints. Science. 2015 Aug 21; 349(6250):788-9. PMID: 26293938.
    Citations: 14     Fields:    Translation:PHPublic Health
  30. Groen SC, Humphrey PT, Chevasco D, Ausubel FM, Pierce NE, Whiteman NK. Pseudomonas syringae enhances herbivory by suppressing the reactive oxygen burst in Arabidopsis. J Insect Physiol. 2016 01; 84:90-102. PMID: 26205072; PMCID: PMC4721946.
    Citations: 8     Fields:    Translation:AnimalsCells
  31. Rajamuthiah R, Jayamani E, Conery AL, Fuchs BB, Kim W, Johnston T, Vilcinskas A, Ausubel FM, Mylonakis E. A Defensin from the Model Beetle Tribolium castaneum Acts Synergistically with Telavancin and Daptomycin against Multidrug Resistant Staphylococcus aureus. PLoS One. 2015; 10(6):e0128576. PMID: 26062137.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  32. Kim W, Conery AL, Rajamuthiah R, Fuchs BB, Ausubel FM, Mylonakis E. Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy. PLoS One. 2015; 10(6):e0127640. PMID: 26039584.
    Citations: 31     Fields:    Translation:AnimalsCells
  33. Haney CH, Samuel BS, Bush J, Ausubel FM. Associations with rhizosphere bacteria can confer an adaptive advantage to plants. Nat Plants. 2015; 1(6). PMID: 27019743.
    Citations: 111     Fields:    
  34. Haney CH, Samuel BS, Bush J, Ausubel FM. Associations with rhizosphere bacteria can confer an adaptive advantage to plants. Nat Plants. 2015; 1:15051. PMID: 27250003.
    Citations:    
  35. Zhang XC, Millet YA, Cheng Z, Bush J, Ausubel FM. Jasmonate signalling in Arabidopsis involves SGT1b-HSP70-HSP90 chaperone complexes. Nat Plants. 2015; 1. PMID: 27054042.
    Citations: 30     Fields:    
  36. Rajamuthiah R, Fuchs BB, Conery AL, Kim W, Jayamani E, Kwon B, Ausubel FM, Mylonakis E. Repurposing salicylanilide anthelmintic drugs to combat drug resistant Staphylococcus aureus. PLoS One. 2015; 10(4):e0124595. PMID: 25897961.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  37. Benedetti M, Pontiggia D, Raggi S, Cheng Z, Scaloni F, Ferrari S, Ausubel FM, Cervone F, De Lorenzo G. Plant immunity triggered by engineered in vivo release of oligogalacturonides, damage-associated molecular patterns. Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17):5533-8. PMID: 25870275; PMCID: PMC4418913.
    Citations: 69     Fields:    Translation:AnimalsCells