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Ausubel, Frederick
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Frederick M. Ausubel
Title
Professor of Genetics, Emeritus
Institution
Harvard Medical School
Department
Emeritus
Address
Massachusetts General Hospital
Simches Research Ctr CPZN# 7808
185 Cambridge St
Boston MA 02114
Phone
617/726-5969
Fax
617/726-5949
vCard
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research activities and funding
|
selected publications
|
Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can
login
to make corrections and additions.
Most Recent
|
List All
R43DK127754
(AUSUBEL, FREDERICK M)
Jul 1, 2021 - Jun 30, 2022
NIH
First-in-class small molecule therapeutics to enhance gut barrier function in inflammatory bowel disease
Role: Principal Investigator
R43HL156593
(AUSUBEL, FREDERICK M)
Jul 1, 2021 - Dec 31, 2021
NIH
First-in-class small molecules that enhance lung barrier function during acute respiratory distress syndrome (ARDS) as potential therapeutics for COVID-19
Role: Principal Investigator
R43AR072556
(AUSUBEL, FREDERICK M)
Aug 1, 2017 - Apr 30, 2018
NIH
Discovering Novel Therapeutics for Myotonic Dystrophy Type 1 (DM1)
Role: Principal Investigator
R01AI085581
(AUSUBEL, FREDERICK M)
Sep 28, 2009 - Aug 31, 2015
NIH
Identifying novel anti-infectives by high through-put screening in whole animals
Role: Principal Investigator
P01AI083214
(GILMORE, MICHAEL S)
Sep 1, 2009 - Aug 31, 2021
NIH
Harvard-wide Program on Antibiotic Resistance
Role: Principal Investigator
R01AI072508
(AUSUBEL, FREDERICK M)
Dec 15, 2006 - Nov 30, 2009
NIH
Novel whole-animal screens for anti-microbials
Role: Principal Investigator
R01AI064332
(AUSUBEL, FREDERICK M)
Mar 1, 2005 - Feb 28, 2010
NIH
Studies of Caenorhabditis elegans innate immunity
Role: Principal Investigator
P01AI044220
(AUSUBEL, FREDERICK M)
Sep 30, 1998 - Jun 30, 2010
NIH
Innate Immunity in Vertebrates and Insects
Role: Principal Investigator
P30DK040561
(GRINSPOON, STEVEN K.)
Sep 30, 1994 - Jul 31, 2022
NIH
Nutrition Obesity Research Center at Harvard
Role: Co-Principal Investigator
R37GM048707
(AUSUBEL, FREDERICK M)
Jan 1, 1993 - Dec 31, 2015
NIH
Genetic Analysis of the Plant Defense Response
Role: Principal Investigator
R01GM048707
(AUSUBEL, FREDERICK M)
Jan 1, 1993 - Dec 31, 2004
NIH
GENETIC ANALYSIS OF THE PLANT DEFENSE RESPONSE
Role: Principal Investigator
Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
login
to make corrections and additions.
Newest
|
Oldest
|
Most Cited
|
Most Discussed
|
Timeline
|
Field Summary
|
Plain Text
PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Sella Y, Broderick NA, Stouffer K, McEwan DL,
Ausubel FM
, Casadevall A, Bergman A. Chaotic signatures in host-microbe interactions. bioRxiv. 2022 Dec 14.
PMID:
36561184
; PMCID:
PMC9774220
.
Citations:
Kim SM, Zou G, Kim H, Kang M, Ahn S, Heo HY, Kim JS, Lim KM,
Ausubel FM
, Mylonakis E, Gao H, Kim W. Antimicrobial activity of the membrane-active compound nTZDpa is enhanced at low pH. Biomed Pharmacother. 2022 Jun; 150:112977.
PMID:
35447554
.
Citations:
3
Fields:
Bio
Biology
Dru
Drug Therapy
Med
Medicine (General)
Translation:
Humans
Cells
Vasquez-Rifo A, Cook J, McEwan DL, Shikara D,
Ausubel FM
, Di Cara F, Cheng Z. ABCDs of the Relative Contributions of Pseudomonas aeruginosa Quorum Sensing Systems to Virulence in Diverse Nonvertebrate Hosts. mBio. 2022 04 26; 13(2):e0041722.
PMID:
35311532
; PMCID:
PMC9040828
.
Citations:
Fields:
Mic
Microbiology
Translation:
Animals
Cells
Xie F, Dai S, Zhao Y, Huang P, Yu S, Ren B, Wang Q, Ji Z,
Alterovitz G
, Zhang Q, Zhang J, Chen X, Jiang L, Song F, Liu H,
Ausubel FM
, Liu X, Dai H, Zhang L. Generation of Fluorinated Amychelin Siderophores against Pseudomonas aeruginosa Infections by a Combination of Genome Mining and Mutasynthesis. Cell Chem Biol. 2020 12 17; 27(12):1532-1543.e6.
PMID:
33186541
.
Citations:
2
Fields:
Bio
Biochemistry
Bio
Biology
Che
Chemistry
Translation:
Animals
Cells
Lee K, Escobar I, Jang Y, Kim W,
Ausubel FM
, Mylonakis E. In the Model Host Caenorhabditis elegans, Sphingosine-1-Phosphate-Mediated Signaling Increases Immunity toward Human Opportunistic Bacteria. Int J Mol Sci. 2020 Oct 22; 21(21).
PMID:
33105563
.
Citations:
2
Fields:
Bio
Biochemistry
Che
Chemistry
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Khader R, Tharmalingam N, Mishra B, Felix L,
Ausubel FM
, Kelso MJ, Mylonakis E. Characterization of Five Novel Anti-MRSA Compounds Identified Using a Whole-Animal Caenorhabditis elegans/Galleria mellonella Sequential-Screening Approach. Antibiotics (Basel). 2020 Jul 27; 9(8).
PMID:
32726955
; PMCID:
PMC7459823
.
Citations:
3
Kim W, Zou G, Pan W, Fricke N, Faizi HA, Kim SM, Khader R, Li S, Lee K, Escorba I, Vlahovska PM, Gao H,
Ausubel FM
, Mylonakis E. The Neutrally Charged Diarylurea Compound PQ401 Kills Antibiotic-Resistant and Antibiotic-Tolerant Staphylococcus aureus. mBio. 2020 06 30; 11(3).
PMID:
32605985
.
Citations:
10
Fields:
Mic
Microbiology
Translation:
Humans
Animals
Cells
Vasquez-Rifo A, Veksler-Lublinsky I, Cheng Z,
Ausubel FM
, Ambros V. The Pseudomonas aeruginosa accessory genome elements influence virulence towards Caenorhabditis elegans. Genome Biol. 2019 12 10; 20(1):270.
PMID:
31823826
; PMCID:
PMC6902481
.
Citations:
13
Fields:
Gen
Genetics
Translation:
Animals
Cells
Kim W, Zou G, Hari TPA, Wilt IK, Zhu W, Galle N, Faizi HA, Hendricks GL, Tori K, Pan W, Huang X, Steele AD, Csatary EE, Dekarske MM, Rosen JL, Ribeiro NQ, Lee K, Port J, Fuchs BB, Vlahovska PM, Wuest WM, Gao H,
Ausubel FM
, Mylonakis E. A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus. Proc Natl Acad Sci U S A. 2019 08 13; 116(33):16529-16534.
PMID:
31358625
; PMCID:
PMC6697817
.
Citations:
46
Fields:
Sci
Science
Translation:
Animals
Cells
Yuen GJ
,
Ausubel FM
. Both live and dead Enterococci activate Caenorhabditis elegans host defense via immune and stress pathways. Virulence. 2018 12 31; 9(1):683-699.
PMID:
29436902
.
Citations:
31
Fields:
Mic
Microbiology
Translation:
Animals
Cells
Ausubel FM
. Tracing My Roots: How I Became a Plant Biologist. Annu Rev Genet. 2018 11 23; 52:1-20.
PMID:
30192637
.
Citations:
Fields:
Gen
Genetics
Translation:
Animals
Cells
Kim W, Steele AD, Zhu W, Csatary EE, Fricke N, Dekarske MM, Jayamani E, Pan W, Kwon B, Sinitsa IF, Rosen JL,
Conery AL
, Fuchs BB, Vlahovska PM,
Ausubel FM
, Gao H, Wuest WM, Mylonakis E. Discovery and Optimization of nTZDpa as an Antibiotic Effective Against Bacterial Persisters. ACS Infect Dis. 2018 11 09; 4(11):1540-1545.
PMID:
30132650
; PMCID:
PMC6468991
.
Citations:
19
Fields:
Ant
Anti-Infective Agents
Dru
Drug Therapy
Mic
Microbiology
Translation:
Humans
Cells
Drenkard E
, Hibbler RM, Gutu DA, Eaton AD, Silverio AL,
Ausubel FM
,
Hurley BP
,
Yonker LM
. Replication of the Ordered, Nonredundant Library of Pseudomonas aeruginosa strain PA14 Transposon Insertion Mutants. J Vis Exp. 2018 05 04; (135).
PMID:
29781996
.
Citations:
2
Fields:
Bio
Biology
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Slatko BE, Gardner AF,
Ausubel FM
. Overview of Next-Generation Sequencing Technologies. Curr Protoc Mol Biol. 2018 04; 122(1):e59.
PMID:
29851291
.
Citations:
163
Fields:
Mol
Molecular Biology
Translation:
Humans
Kim W, Zhu W, Hendricks GL, Van Tyne D, Steele AD, Keohane CE, Fricke N,
Conery AL
, Shen S, Pan W, Lee K, Rajamuthiah R, Fuchs BB, Vlahovska PM, Wuest WM,
Gilmore MS
, Gao H,
Ausubel FM
, Mylonakis E. A new class of synthetic retinoid antibiotics effective against bacterial persisters. Nature. 2018 04 05; 556(7699):103-107.
PMID:
29590091
.
Citations:
114
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Haller S, Franchet A, Hakkim A, Chen J,
Drenkard E
, Yu S, Schirmeier S, Li Z, Martins N,
Ausubel FM
, LiƩgeois S, Ferrandon D. Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization. EMBO Rep. 2018 05; 19(5).
PMID:
29523648
; PMCID:
PMC5934776
.
Citations:
8
Fields:
Mol
Molecular Biology
Translation:
Animals
Cells
Haney CH, Wiesmann CL, Shapiro LR, Melnyk RA, O'Sullivan LR, Khorasani S, Xiao L, Han J, Bush J, Carrillo J, Pierce NE,
Ausubel FM
. Rhizosphere-associated Pseudomonas induce systemic resistance to herbivores at the cost of susceptibility to bacterial pathogens. Mol Ecol. 2018 04; 27(8):1833-1847.
PMID:
29087012
.
Citations:
16
Fields:
Env
Environmental Health
Mol
Molecular Biology
Translation:
Animals
Cells
Koeva M, Gutu AD, Hebert W, Wager JD,
Yonker LM
, O'Toole GA,
Ausubel FM
, Moskowitz SM, Joseph-McCarthy D. An Antipersister Strategy for Treatment of Chronic Pseudomonas aeruginosa Infections. Antimicrob Agents Chemother. 2017 12; 61(12).
PMID:
28923873
; PMCID:
PMC5700368
.
Citations:
17
Fields:
Ant
Anti-Infective Agents
Translation:
Humans
Cells
Cezairliyan B,
Ausubel FM
. Investment in secreted enzymes during nutrient-limited growth is utility dependent. Proc Natl Acad Sci U S A. 2017 09 12; 114(37):E7796-E7802.
PMID:
28847943
; PMCID:
PMC5604031
.
Citations:
15
Fields:
Sci
Science
Translation:
Cells
Jayamani E, Tharmalingam N, Rajamuthiah R, Coleman JJ, Kim W, Okoli I, Hernandez AM, Lee K, Nau GJ,
Ausubel FM
, Mylonakis E. Characterization of a Francisella tularensis-Caenorhabditis elegans Pathosystem for the Evaluation of Therapeutic Compounds. Antimicrob Agents Chemother. 2017 09; 61(9).
PMID:
28652232
; PMCID:
PMC5571314
.
Citations:
9
Fields:
Ant
Anti-Infective Agents
Translation:
Humans
Animals
Cells
Urbach JM,
Ausubel FM
. The NBS-LRR architectures of plant R-proteins and metazoan NLRs evolved in independent events. Proc Natl Acad Sci U S A. 2017 Jan 31; 114(5):1063-1068.
PMID:
28096345
; PMCID:
PMC5293065
.
Citations:
46
Fields:
Sci
Science
Translation:
Animals
Cells
Gregory KE, Samuel BS, Houghteling P, Shan G,
Ausubel FM
,
Sadreyev RI
,
Walker WA
. Influence of maternal breast milk ingestion on acquisition of the intestinal microbiome in preterm infants. Microbiome. 2016 12 30; 4(1):68.
PMID:
28034306
.
Citations:
77
Fields:
Gen
Genetics
Mic
Microbiology
Translation:
Humans
Cells
McEwan DL, Feinbaum RL, Stroustrup N,
Haas W
,
Conery AL
, Anselmo A,
Sadreyev R
,
Ausubel FM
. Tribbles ortholog NIPI-3 and bZIP transcription factor CEBP-1 regulate a Caenorhabditis elegans intestinal immune surveillance pathway. BMC Biol. 2016 12 07; 14(1):105.
PMID:
27927200
; PMCID:
PMC5143455
.
Citations:
15
Fields:
Bio
Biology
Translation:
Animals
Cells
Newman M,
Ausubel FM
. Introduction to Gene Editing and Manipulation Using CRISPR/Cas9 Technology. Curr Protoc Mol Biol. 2016 07 01; 115:31.4.1-31.4.6.
PMID:
27366890
.
Citations:
3
Fields:
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Liu S,
Bartnikas LM
, Volko SM,
Ausubel FM
, Tang D. Mutation of the Glucosinolate Biosynthesis Enzyme Cytochrome P450 83A1 Monooxygenase Increases Camalexin Accumulation and Powdery Mildew Resistance. Front Plant Sci. 2016; 7:227.
PMID:
26973671
; PMCID:
PMC4774424
.
Citations:
9
Kim W, Fricke N,
Conery AL
, Fuchs BB, Rajamuthiah R, Jayamani E, Vlahovska PM,
Ausubel FM
, Mylonakis E. NH125 kills methicillin-resistant Staphylococcus aureus persisters by lipid bilayer disruption. Future Med Chem. 2016; 8(3):257-69.
PMID:
26910612
.
Citations:
14
Fields:
Che
Chemistry
Pha
Pharmacy
Translation:
Cells
Cervone F,
Ausubel FM
, De Lorenzo G. Enhancing immunity by engineering DAMPs. Oncotarget. 2015 Oct 06; 6(30):28523-4.
PMID:
26387132
.
Citations:
2
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Rajamuthiah R, Jayamani E, Majed H,
Conery AL
, Kim W, Kwon B, Fuchs BB, Kelso MJ,
Ausubel FM
, Mylonakis E. Antibacterial properties of 3-(phenylsulfonyl)-2-pyrazinecarbonitrile. Bioorg Med Chem Lett. 2015 Nov 15; 25(22):5203-7.
PMID:
26459212
; PMCID:
PMC4718707
.
Citations:
4
Fields:
Bio
Biochemistry
Che
Chemistry
Translation:
Humans
Animals
Cells
Haney CH,
Ausubel FM
. MICROBIOME. Plant microbiome blueprints. Science. 2015 Aug 21; 349(6250):788-9.
PMID:
26293938
.
Citations:
14
Fields:
Sci
Science
Translation:
PH
Public Health
Groen SC, Humphrey PT, Chevasco D,
Ausubel FM
, Pierce NE, Whiteman NK. Pseudomonas syringae enhances herbivory by suppressing the reactive oxygen burst in Arabidopsis. J Insect Physiol. 2016 01; 84:90-102.
PMID:
26205072
; PMCID:
PMC4721946
.
Citations:
8
Fields:
Zoo
Zoology
Translation:
Animals
Cells
Rajamuthiah R, Jayamani E,
Conery AL
, Fuchs BB, Kim W, Johnston T, Vilcinskas A,
Ausubel FM
, Mylonakis E. A Defensin from the Model Beetle Tribolium castaneum Acts Synergistically with Telavancin and Daptomycin against Multidrug Resistant Staphylococcus aureus. PLoS One. 2015; 10(6):e0128576.
PMID:
26062137
.
Citations:
17
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Kim W,
Conery AL
, Rajamuthiah R, Fuchs BB,
Ausubel FM
, Mylonakis E. Identification of an Antimicrobial Agent Effective against Methicillin-Resistant Staphylococcus aureus Persisters Using a Fluorescence-Based Screening Strategy. PLoS One. 2015; 10(6):e0127640.
PMID:
26039584
.
Citations:
31
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Cells
Haney CH, Samuel BS, Bush J,
Ausubel FM
. Associations with rhizosphere bacteria can confer an adaptive advantage to plants. Nat Plants. 2015; 1(6).
PMID:
27019743
.
Citations:
111
Fields:
Bot
Botany
Gen
Genetics
Haney CH, Samuel BS, Bush J,
Ausubel FM
. Associations with rhizosphere bacteria can confer an adaptive advantage to plants. Nat Plants. 2015; 1:15051.
PMID:
27250003
.
Citations:
Zhang XC, Millet YA, Cheng Z, Bush J,
Ausubel FM
. Jasmonate signalling in Arabidopsis involves SGT1b-HSP70-HSP90 chaperone complexes. Nat Plants. 2015; 1.
PMID:
27054042
.
Citations:
30
Fields:
Bot
Botany
Gen
Genetics
Rajamuthiah R, Fuchs BB,
Conery AL
, Kim W, Jayamani E, Kwon B,
Ausubel FM
, Mylonakis E. Repurposing salicylanilide anthelmintic drugs to combat drug resistant Staphylococcus aureus. PLoS One. 2015; 10(4):e0124595.
PMID:
25897961
.
Citations:
63
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Benedetti M, Pontiggia D, Raggi S, Cheng Z, Scaloni F, Ferrari S,
Ausubel FM
, Cervone F, De Lorenzo G. Plant immunity triggered by engineered in vivo release of oligogalacturonides, damage-associated molecular patterns. Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17):5533-8.
PMID:
25870275
; PMCID:
PMC4418913
.
Citations:
69
Fields:
Sci
Science
Translation:
Animals
Cells