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profileAnders Hayden Berg, Ph.D., M.D.

TitleAssistant Professor of Pathology
InstitutionBeth Israel Deaconess Medical Center
DepartmentPathology
AddressBeth Israel Deaconess Medical Center
Pathology
330 Brookline Ave
Boston MA 02215
Phone617/667-4343
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My laboratory's research activities in are founded on hypothesis-driven selection of novel or undeveloped biomarkers that are directly associated with the pathophysiology of disease, development of LC-MS/MS assay for these biomarkers, and testing for associations between these biomarkers and disease outcomes in patients. Greater understanding of the chemical toxicities of urea in kidney disease and glucose in diabetes mellitus are needed in order to devise novel approaches to their diagnosis and treatment, and thus my investigative interests also extend into the basic chemical pathophysiology of disease. I have discovered a blood test for carbamylated albumin whose levels are strongly associated with survival in patients with kidney disease. This assay was designed based upon the paradigm of the assay for hemoglobin A1c used in patients with diabetes mellitus. We hypothesize that this test may be useful for more optimized treatment of kidney disease dialysis and kidney transplant, and that the mechanism of toxicity by urea-induced carbamylation is increased cellular oxidative stress.

In addition to investigation into the pathophysiology of uremia in kidney disease, I am also interested in the pathophysiology and diagnostic testing of vitamin D. I helped to develop methods for measurement of bioavailable 25-hydroxyvitamin D along with Ravi Thadani and Ananth Karumanchi, and we have found significant evidence that levels of serum bioavailable vitamin D are more reliably predictive of bone mineral and calcium homeostasis than are standard tests for total vitamin D. We are continuing these studies in order to prove that bioavailable 25-hydroxyvitamin D is a superior method for screening for vitamin D deficiency. This work may result in significant improvements in clinical care and understanding of the physiology of vitamin D.

Improvement in the diagnosis and management of diabetes mellitus through innovations in laboratory testing is one of my primary career goals. My project seeking to develop an assay for hemoglobin A1c that adjusts for differences in patients’ erythrocyte life span is based upon the observation that there is significant variability in erythrocyte life span, which influences hemoglobin A1c values independent of patients’ average glucose concentrations. I am looking for spontaneous chemical modifications of erythrocyte proteins that can serve as “molecular clocks” for the determination of patients’ red cell age. This would be used to estimate erythrocyte age and adjust for the effects of age on hemoglobin A1c values. This project may significantly improve an already essential tool for the diagnosis, therapy, and improved outcomes in patients with diabetes mellitus.


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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R56HL133399     (BERG, ANDERS HAYDEN)Sep 16, 2016 - Aug 31, 2017
NIH/NHLBI
Protein carbamylation and uremic cardiomyopathy in chronic kidney disease
Role: Principal Investigator

K08HL121801     (BERG, ANDERS HAYDEN)Sep 1, 2014 - May 31, 2018
NIH/NHLBI
The role of carbamylation in uremia associated heart disease
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Mendoza A, Astapova I, Shimizu H, Gallop MR, Al-Sowaimel L, MacGowan SMD, Bergmann T, Berg AH, Tenen DE, Jacobs C, Lyubetskaya A, Tsai L, Hollenberg AN. NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor. Proc Natl Acad Sci U S A. 2017 Sep 18. PMID: 28923959.
    View in: PubMed
  2. Kang AD, Smith KP, Eliopoulos GM, Berg AH, McCoy C, Kirby JE. Invitro Apramycin Activity against multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa. Diagn Microbiol Infect Dis. 2017 Jun; 88(2):188-191. PMID: 28341099.
    View in: PubMed
  3. Shukha K, Mueller JL, Chung RT, Curry MP, Friedman DJ, Pollak MR, Berg AH. Most ApoL1 Is Secreted by the Liver. J Am Soc Nephrol. 2017 Apr; 28(4):1079-1083. PMID: 27932478.
    View in: PubMed
  4. Chen CW, Drechsler C, Suntharalingam P, Karumanchi SA, Wanner C, Berg AH. High Glycated Albumin and Mortality in Persons with Diabetes Mellitus on Hemodialysis. Clin Chem. 2017 Feb; 63(2):477-485. PMID: 27737895.
    View in: PubMed
  5. Kalim S, Trottier CA, Wenger JB, Wibecan J, Ahmed R, Ankers E, Karumanchi SA, Thadhani R, Berg AH. Longitudinal Changes in Protein Carbamylation and Mortality Risk after Initiation of Hemodialysis. Clin J Am Soc Nephrol. 2016 Oct 07; 11(10):1809-1816. PMID: 27445162.
    View in: PubMed
  6. Perl J, Kalim S, Wald R, Goldstein MB, Yan AT, Noori N, Kiaii M, Wenger J, Chan C, Thadhani RI, Karumanchi SA, Berg AH. Reduction of carbamylated albumin by extended hemodialysis. Hemodial Int. 2016 Oct; 20(4):510-521. PMID: 27329430.
    View in: PubMed
  7. Tran MT, Zsengeller ZK, Berg AH, Khankin EV, Bhasin MK, Kim W, Clish CB, Stillman IE, Karumanchi SA, Rhee EP, Parikh SM. PGC1a drives NAD biosynthesis linking oxidative metabolism to renal protection. Nature. 2016 Mar 24; 531(7595):528-32. PMID: 26982719; PMCID: PMC4909121.
  8. Baltajian K, Bajracharya S, Salahuddin S, Berg AH, Geahchan C, Wenger JB, Thadhani R, Karumanchi SA, Rana S. Sequential plasma angiogenic factors levels in women with suspected preeclampsia. Am J Obstet Gynecol. 2016 Jul; 215(1):89.e1-89.e10. PMID: 26827880.
    View in: PubMed
  9. de Seigneux S, Lundby AK, Berchtold L, Berg AH, Saudan P, Lundby C. Increased Synthesis of Liver Erythropoietin with CKD. J Am Soc Nephrol. 2016 Aug; 27(8):2265-9. PMID: 26757994; PMCID: PMC4978039 [Available on 08/01/17].
  10. Berg AH, Powe CE, Evans MK, Wenger J, Ortiz G, Zonderman AB, Suntharalingam P, Lucchesi K, Powe NR, Karumanchi SA, Thadhani RI. 24,25-Dihydroxyvitamin d3 and vitamin D status of community-dwelling black and white Americans. Clin Chem. 2015 Jun; 61(6):877-84. PMID: 25922442; PMCID: PMC4686255.
  11. Kalim S, Ortiz G, Trottier CA, Deferio JJ, Karumanchi SA, Thadhani RI, Berg AH. The Effects of Parenteral Amino Acid Therapy on Protein Carbamylation in Maintenance Hemodialysis Patients. J Ren Nutr. 2015 Jul; 25(4):388-92. PMID: 25753604; PMCID: PMC4469570.
  12. Drechsler C, Kalim S, Wenger JB, Suntharalingam P, Hod T, Thadhani RI, Karumanchi SA, Wanner C, Berg AH. Protein carbamylation is associated with heart failure and mortality in diabetic patients with end-stage renal disease. Kidney Int. 2015 Jun; 87(6):1201-8. PMID: 25671766; PMCID: PMC4449819.
  13. Welles CC, Whooley MA, Karumanchi SA, Hod T, Thadhani R, Berg AH, Ix JH, Mukamal KJ. The authors reply. Am J Epidemiol. 2014 Oct 01; 180(7):758. PMID: 25150267.
    View in: PubMed
  14. Xia D, McShine R, Berg AH. Misleading hemoglobin A1c levels in a patient with paroxysmal nocturnal hemoglobinuria. Am J Clin Pathol. 2014 Aug; 142(2):261-5. PMID: 25015870.
    View in: PubMed
  15. Kalim S, Karumanchi SA, Thadhani RI, Berg AH. Protein carbamylation in kidney disease: pathogenesis and clinical implications. Am J Kidney Dis. 2014 Nov; 64(5):793-803. PMID: 25037561; PMCID: PMC4209336.
  16. Moss AC, Lillis Y, Edwards George JB, Choudhry NK, Berg AH, Cheifetz AS, Horowitz G, Leffler DA. Attitudes to mesalamine questionnaire: a novel tool to predict mesalamine nonadherence in patients with IBD. Am J Gastroenterol. 2014 Dec; 109(12):1850-5. PMID: 24913040.
    View in: PubMed
  17. Welles CC, Whooley MA, Karumanchi SA, Hod T, Thadhani R, Berg AH, Ix JH, Mukamal KJ. Welles et al. respond to "Low vitamin D and cardiovascular disease". Am J Epidemiol. 2014 Jun 01; 179(11):1291-2. PMID: 24699785; PMCID: PMC4036211.
  18. Welles CC, Whooley MA, Karumanchi SA, Hod T, Thadhani R, Berg AH, Ix JH, Mukamal KJ. Vitamin D deficiency and cardiovascular events in patients with coronary heart disease: data from the Heart and Soul Study. Am J Epidemiol. 2014 Jun 01; 179(11):1279-87. PMID: 24699783; PMCID: PMC4036212.
  19. Felton D, Ganetsky M, Berg AH. Osmolal gap without anion gap in a 43-year-old man. Clin Chem. 2014 Mar; 60(3):446-8. PMID: 24584407.
    View in: PubMed
  20. Powe CE, Evans MK, Wenger J, Zonderman AB, Berg AH, Nalls M, Tamez H, Zhang D, Bhan I, Karumanchi SA, Powe NR, Thadhani R. Vitamin D-binding protein and vitamin D status of black Americans and white Americans. N Engl J Med. 2013 Nov 21; 369(21):1991-2000. PMID: 24256378; PMCID: PMC4030388.
  21. Kalim S, Tamez H, Wenger J, Ankers E, Trottier CA, Deferio JJ, Berg AH, Karumanchi SA, Thadhani RI. Carbamylation of serum albumin and erythropoietin resistance in end stage kidney disease. Clin J Am Soc Nephrol. 2013 Nov; 8(11):1927-34. PMID: 23970130; PMCID: PMC3817911.
  22. Berg AH, Drechsler C, Wenger J, Buccafusca R, Hod T, Kalim S, Ramma W, Parikh SM, Steen H, Friedman DJ, Danziger J, Wanner C, Thadhani R, Karumanchi SA. Carbamylation of serum albumin as a risk factor for mortality in patients with kidney failure. Sci Transl Med. 2013 Mar 06; 5(175):175ra29. PMID: 23467560; PMCID: PMC3697767.
  23. Gifford AE, Berg AH, Lahiff C, Cheifetz AS, Horowitz G, Moss AC. A random urine test can identify patients at risk of mesalamine non-adherence: a prospective study. Am J Gastroenterol. 2013 Feb; 108(2):249-55. PMID: 23295279.
    View in: PubMed
  24. de Koning L, Al-Turkmani MR, Berg AH, Shkreta A, Law T, Kellogg MD. Variation in clinical vitamin D status by DiaSorin Liaison and LC-MS/MS in the presence of elevated 25-OH vitamin D2. Clin Chim Acta. 2013 Jan 16; 415:54-8. PMID: 22975531.
    View in: PubMed
  25. Bansal N, Hsu CY, Whooley M, Berg AH, Ix JH. Relationship of urine dopamine with phosphorus homeostasis in humans: the heart and soul study. Am J Nephrol. 2012; 35(6):483-90. PMID: 22572568; PMCID: PMC3873852.
  26. Bhan I, Powe CE, Berg AH, Ankers E, Wenger JB, Karumanchi SA, Thadhani RI. Bioavailable vitamin D is more tightly linked to mineral metabolism than total vitamin D in incident hemodialysis patients. Kidney Int. 2012 Jul; 82(1):84-9. PMID: 22398410; PMCID: PMC3376220.
  27. Wan L, Zou W, Gao D, Inuzuka H, Fukushima H, Berg AH, Drapp R, Shaik S, Hu D, Lester C, Eguren M, Malumbres M, Glimcher LH, Wei W. Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Mol Cell. 2011 Dec 09; 44(5):721-33. PMID: 22152476; PMCID: PMC3240853.
  28. Powe CE, Ricciardi C, Berg AH, Erdenesanaa D, Collerone G, Ankers E, Wenger J, Karumanchi SA, Thadhani R, Bhan I. Vitamin D-binding protein modifies the vitamin D-bone mineral density relationship. J Bone Miner Res. 2011 Jul; 26(7):1609-16. PMID: 21416506; PMCID: PMC3351032.
  29. Gao D, Wan L, Inuzuka H, Berg AH, Tseng A, Zhai B, Shaik S, Bennett E, Tron AE, Gasser JA, Lau A, Gygi SP, Harper JW, DeCaprio JA, Toker A, Wei W. Rictor forms a complex with Cullin-1 to promote SGK1 ubiquitination and destruction. Mol Cell. 2010 Sep 10; 39(5):797-808. PMID: 20832730; PMCID: PMC2939073.
  30. Berg AH, Sacks DB. Haemoglobin A1c analysis in the management of patients with diabetes: from chaos to harmony. J Clin Pathol. 2008 Sep; 61(9):983-7. PMID: 18755722.
    View in: PubMed
  31. Mitchell G. Scott (Editor), Ann M. Gronowski (Editor), Charles S. Eby (Editor). Mitchell G. Scott (Editor), Ann M. Gronowski (Editor), Charles S. Eby (Editor), Norbert W. Tietz (Editor). Tietz's Applied Laboratory Medicine. 2007; 199-215.
  32. Melanson SE, Berg A, Jarolim P, Tanasijevic MJ, McElrath TF. Validation of a formula that calculates the estimated risk of respiratory distress syndrome. Obstet Gynecol. 2006 Dec; 108(6):1471-6. PMID: 17138782.
    View in: PubMed
  33. Mitchell G. Scott (Editor), Ann M. Gronowski (Editor), Charles S. Eby (Editor), Norbert W. Tietz (Editor). Tietz's Applied Laboratory Medicine, 2nd Edition. 2006.
  34. Darabi K, Berg AH. Rituximab can be combined with daily plasma exchange to achieve effective B-cell depletion and clinical improvement in acute autoimmune TTP. Am J Clin Pathol. 2006 Apr; 125(4):592-7. PMID: 16627268.
    View in: PubMed
  35. Hertzel AV, Smith LA, Berg AH, Cline GW, Shulman GI, Scherer PE, Bernlohr DA. Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice. Am J Physiol Endocrinol Metab. 2006 May; 290(5):E814-23. PMID: 16303844.
    View in: PubMed
  36. Berg AH, Scherer PE. Adipose tissue, inflammation, and cardiovascular disease. Circ Res. 2005 May 13; 96(9):939-49. PMID: 15890981.
    View in: PubMed
  37. Lin Y, Berg AH, Iyengar P, Lam TK, Giacca A, Combs TP, Rajala MW, Du X, Rollman B, Li W, Hawkins M, Barzilai N, Rhodes CJ, Fantus IG, Brownlee M, Scherer PE. The hyperglycemia-induced inflammatory response in adipocytes: the role of reactive oxygen species. J Biol Chem. 2005 Feb 11; 280(6):4617-26. PMID: 15536073.
    View in: PubMed
  38. Berg AH, Lin Y, Lisanti MP, Scherer PE. Adipocyte differentiation induces dynamic changes in NF-kappaB expression and activity. Am J Physiol Endocrinol Metab. 2004 Dec; 287(6):E1178-88. PMID: 15251865.
    View in: PubMed
  39. Qi Y, Takahashi N, Hileman SM, Patel HR, Berg AH, Pajvani UB, Scherer PE, Ahima RS. Adiponectin acts in the brain to decrease body weight. Nat Med. 2004 May; 10(5):524-9. PMID: 15077108.
    View in: PubMed
  40. Combs TP, Pajvani UB, Berg AH, Lin Y, Jelicks LA, Laplante M, Nawrocki AR, Rajala MW, Parlow AF, Cheeseboro L, Ding YY, Russell RG, Lindemann D, Hartley A, Baker GR, Obici S, Deshaies Y, Ludgate M, Rossetti L, Scherer PE. A transgenic mouse with a deletion in the collagenous domain of adiponectin displays elevated circulating adiponectin and improved insulin sensitivity. Endocrinology. 2004 Jan; 145(1):367-83. PMID: 14576179.
    View in: PubMed
  41. Combs TP, Berg AH, Rajala MW, Klebanov S, Iyengar P, Jimenez-Chillaron JC, Patti ME, Klein SL, Weinstein RS, Scherer PE. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes. 2003 Feb; 52(2):268-76. PMID: 12540596.
    View in: PubMed
  42. Pharmacological and Epidemiological Studies of the Adipocyte Secretory Protein Acrp30/Adiponectin. 2003.
  43. Pajvani UB, Du X, Combs TP, Berg AH, Rajala MW, Schulthess T, Engel J, Brownlee M, Scherer PE. Structure-function studies of the adipocyte-secreted hormone Acrp30/adiponectin. Implications fpr metabolic regulation and bioactivity. J Biol Chem. 2003 Mar 14; 278(11):9073-85. PMID: 12496257.
    View in: PubMed
  44. Gabriely I, Ma XH, Yang XM, Atzmon G, Rajala MW, Berg AH, Scherer P, Rossetti L, Barzilai N. Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes. 2002 Oct; 51(10):2951-8. PMID: 12351432.
    View in: PubMed
  45. Menzaghi C, Ercolino T, Di Paola R, Berg AH, Warram JH, Scherer PE, Trischitta V, Doria A. A haplotype at the adiponectin locus is associated with obesity and other features of the insulin resistance syndrome. Diabetes. 2002 Jul; 51(7):2306-12. PMID: 12086965.
    View in: PubMed
  46. Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, Zhang BB, Tanen M, Berg AH, O'Rahilly S, Savage DB, Chatterjee K, Weiss S, Larson PJ, Gottesdiener KM, Gertz BJ, Charron MJ, Scherer PE, Moller DE. Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPAR? Agonists: A Potential Mechanism of Insulin Sensitization. Endocrinology. 2002 Mar 01; 143(3):998-1007. PMID: 28201619.
    View in: PubMed
  47. Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, Zhang BB, Tanen M, Berg AH, O'Rahilly S, Savage DB, Chatterjee K, Weiss S, Larson PJ, Gottesdiener KM, Gertz BJ, Charron MJ, Scherer PE, Moller DE. Induction of adipocyte complement-related protein of 30 kilodaltons by PPARgamma agonists: a potential mechanism of insulin sensitization. Endocrinology. 2002 Mar; 143(3):998-1007. PMID: 11861525.
    View in: PubMed
  48. Berg AH, Combs TP, Scherer PE. ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism. Trends Endocrinol Metab. 2002 Mar; 13(2):84-9. PMID: 11854024.
    View in: PubMed
  49. Combs TP, Berg AH, Obici S, Scherer PE, Rossetti L. Endogenous glucose production is inhibited by the adipose-derived protein Acrp30. J Clin Invest. 2001 Dec; 108(12):1875-81. PMID: 11748271; PMCID: PMC209474.
  50. Berg AH, Combs TP, Du X, Brownlee M, Scherer PE. The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat Med. 2001 Aug; 7(8):947-53. PMID: 11479628.
    View in: PubMed
  51. Engelman JA, Berg AH, Lewis RY, Lisanti MP, Scherer PE. Tumor necrosis factor alpha-mediated insulin resistance, but not dedifferentiation, is abrogated by MEK1/2 inhibitors in 3T3-L1 adipocytes. Mol Endocrinol. 2000 Oct; 14(10):1557-69. PMID: 11043572.
    View in: PubMed
  52. Lin Y, Lee H, Berg AH, Lisanti MP, Shapiro L, Scherer PE. The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem. 2000 Aug 11; 275(32):24255-63. PMID: 10823826.
    View in: PubMed
  53. Engelman JA, Berg AH, Lewis RY, Lin A, Lisanti MP, Scherer PE. Constitutively active mitogen-activated protein kinase kinase 6 (MKK6) or salicylate induces spontaneous 3T3-L1 adipogenesis. J Biol Chem. 1999 Dec 10; 274(50):35630-8. PMID: 10585441.
    View in: PubMed
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