Anders Hayden Berg, Ph.D., M.D.
|Title||Assistant Professor of Pathology|
|Institution||Beth Israel Deaconess Medical Center|
|Address||Beth Israel Deaconess Medical Center|
330 Brookline Ave
Boston MA 02215
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My laboratory's research activities in are founded on hypothesis-driven selection of novel or undeveloped biomarkers that are directly associated with the pathophysiology of disease, development of LC-MS/MS assay for these biomarkers, and testing for associations between these biomarkers and disease outcomes in patients. Greater understanding of the chemical toxicities of urea in kidney disease and glucose in diabetes mellitus are needed in order to devise novel approaches to their diagnosis and treatment, and thus my investigative interests also extend into the basic chemical pathophysiology of disease. I have discovered a blood test for carbamylated albumin whose levels are strongly associated with survival in patients with kidney disease. This assay was designed based upon the paradigm of the assay for hemoglobin A1c used in patients with diabetes mellitus. We hypothesize that this test may be useful for more optimized treatment of kidney disease dialysis and kidney transplant, and that the mechanism of toxicity by urea-induced carbamylation is increased cellular oxidative stress.
In addition to investigation into the pathophysiology of uremia in kidney disease, I am also interested in the pathophysiology and diagnostic testing of vitamin D. I helped to develop methods for measurement of bioavailable 25-hydroxyvitamin D along with Ravi Thadani and Ananth Karumanchi, and we have found significant evidence that levels of serum bioavailable vitamin D are more reliably predictive of bone mineral and calcium homeostasis than are standard tests for total vitamin D. We are continuing these studies in order to prove that bioavailable 25-hydroxyvitamin D is a superior method for screening for vitamin D deficiency. This work may result in significant improvements in clinical care and understanding of the physiology of vitamin D.
Improvement in the diagnosis and management of diabetes mellitus through innovations in laboratory testing is one of my primary career goals. My project seeking to develop an assay for hemoglobin A1c that adjusts for differences in patients’ erythrocyte life span is based upon the observation that there is significant variability in erythrocyte life span, which influences hemoglobin A1c values independent of patients’ average glucose concentrations. I am looking for spontaneous chemical modifications of erythrocyte proteins that can serve as “molecular clocks” for the determination of patients’ red cell age. This would be used to estimate erythrocyte age and adjust for the effects of age on hemoglobin A1c values. This project may significantly improve an already essential tool for the diagnosis, therapy, and improved outcomes in patients with diabetes mellitus.
The research activities and funding listed below are automatically derived from
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R56HL133399 (BERG, ANDERS HAYDEN)Sep 16, 2016 - Aug 31, 2017NIH/NHLBI
Protein carbamylation and uremic cardiomyopathy in chronic kidney disease
Role: Principal Investigator
K08HL121801 (BERG, ANDERS HAYDEN)Sep 1, 2014 - May 31, 2018NIH/NHLBI
The role of carbamylation in uremia associated heart disease
Role: Principal Investigator
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