Harvard Catalyst Profiles

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James Rhee, M.D.

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Biography
Harvard College, Cambridge, MAAB
Harvard Medical School, Boston, MAMD, PhD
Massachusetts General Hospital, Boston, MAInternshipInternal Medicine
Massachusetts General Hospital, Boston, MAResidencyAnesthesia and Critical Care

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K08HL140200 (RHEE, JAMES) Jan 15, 2019 - Dec 31, 2023
    NIH
    The Role of Family with Sequence Similarity 3D (FAM3D) in Cardioprotection and Inflammation after Myocardial Infarction
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Rhee J, Kuznetsov A, McKay T, Lyons M, Houstis N, Mekkonen J, Ethridge B, Ibala R, Hahm E, Gitlin J, Guseh JS, Kitchen R, Rosenzweig A, Shaefi S, Flaczyk A, Qu J, Akeju O. Serum Proteomics of Older Patients Undergoing Major Cardiac Surgery: Identification of Biomarkers Associated With Postoperative Delirium. Front Aging Neurosci. 2021; 13:699763. PMID: 34456709.
    Citations:    
  2. Roh J, Kitchen R, Guseh JS, McNeill J, Aid M, Martinot A, Yu A, Platt C, Rhee J, Weber B, Trager L, Hastings M, Ducat S, Xia P, Castro C, Atlason B, Churchill T, Carli MD, Ellinor P, Barouch D, Ho J, Rosenzweig A. Plasma Proteomics of COVID-19 Associated Cardiovascular Complications: Implications for Pathophysiology and Therapeutics. Res Sq. 2021 Jun 08. PMID: 34127963.
    Citations:    
  3. McKay TB, Rhee J, Colon K, Adelsberger K, Turco I, Mueller A, Qu J, Akeju O. Preliminary Study of Serum Biomarkers Associated With Delirium After Major Cardiac Surgery. J Cardiothorac Vasc Anesth. 2022 01; 36(1):118-124. PMID: 34112563.
    Citations:    Fields:    Translation:Humans
  4. Li H, Hastings MH, Rhee J, Trager LE, Roh JD, Rosenzweig A. Targeting Age-Related Pathways in Heart Failure. Circ Res. 2020 02 14; 126(4):533-551. PMID: 32078451.
    Citations: 22     Fields:    Translation:HumansCells
  5. Chamadia S, Pedemonte JC, Hahm EY, Mekonnen J, Ibala R, Gitlin J, Ethridge BR, Qu J, Vazquez R, Rhee J, Liao ET, Brown EN, Akeju O. Delta oscillations phase limit neural activity during sevoflurane anesthesia. Commun Biol. 2019; 2:415. PMID: 31754645.
    Citations: 9     Translation:HumansCells
  6. Chamadia S, Pedemonte JC, Hahm EY, Mekonnen J, Ibala R, Gitlin J, Ethridge BR, Qu J, Vazquez R, Rhee J, Liao ET, Brown EN, Akeju O. Delta oscillations phase limit neural activity during sevoflurane anesthesia. Commun Biol. 2019 Nov 15; 2(1):415. PMID: 31925268.
    Citations:    
  7. Pavone KJ, Su L, Gao L, Eromo E, Vazquez R, Rhee J, Hobbs LE, Ibala R, Demircioglu G, Purdon PL, Brown EN, Akeju O. Lack of Responsiveness during the Onset and Offset of Sevoflurane Anesthesia Is Associated with Decreased Awake-Alpha Oscillation Power. Front Syst Neurosci. 2017; 11:38. PMID: 28611601.
    Citations: 16     
  8. Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, Seale P, Arany Z. The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue. Genes Dev. 2016 11 15; 30(22):2551-2564. PMID: 27913603.
    Citations: 53     Fields:    Translation:AnimalsCells
  9. Akeju O, Kim SE, Vazquez R, Rhee J, Pavone KJ, Hobbs LE, Purdon PL, Brown EN. Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations. PLoS One. 2016; 11(10):e0163431. PMID: 27711165.
    Citations: 30     Fields:    Translation:HumansCTClinical Trials
  10. Jang C, Oh SF, Wada S, Rowe GC, Liu L, Chan MC, Rhee J, Hoshino A, Kim B, Ibrahim A, Baca LG, Kim E, Ghosh CC, Parikh SM, Jiang A, Chu Q, Forman DE, Lecker SH, Krishnaiah S, Rabinowitz JD, Weljie AM, Baur JA, Kasper DL, Arany Z. A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med. 2016 Apr; 22(4):421-6. PMID: 26950361.
    Citations: 178     Fields:    Translation:HumansAnimals
  11. Roh J, Rhee J, Chaudhari V, Rosenzweig A. The Role of Exercise in Cardiac Aging: From Physiology to Molecular Mechanisms. Circ Res. 2016 Jan 22; 118(2):279-95. PMID: 26838314.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  12. Akeju O, Loggia ML, Catana C, Pavone KJ, Vazquez R, Rhee J, Contreras Ramirez V, Chonde DB, Izquierdo-Garcia D, Arabasz G, Hsu S, Habeeb K, Hooker JM, Napadow V, Brown EN, Purdon PL. Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness. Elife. 2014 Nov 28; 3:e04499. PMID: 25432022.
    Citations: 59     Fields:    Translation:Humans
  13. Akeju O, Pavone KJ, Westover MB, Vazquez R, Prerau MJ, Harrell PG, Hartnack KE, Rhee J, Sampson AL, Habeeb K, Gao L, Lei G, Pierce ET, Walsh JL, Brown EN, Purdon PL. A comparison of propofol- and dexmedetomidine-induced electroencephalogram dynamics using spectral and coherence analysis. Anesthesiology. 2014 Nov; 121(5):978-89. PMID: 25187999.
    Citations: 53     Fields:    Translation:Humans
  14. St-Pierre J, Drori S, Uldry M, Silvaggi JM, Rhee J, Jäger S, Handschin C, Zheng K, Lin J, Yang W, Simon DK, Bachoo R, Spiegelman BM. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell. 2006 Oct 20; 127(2):397-408. PMID: 17055439.
    Citations: 943     Fields:    Translation:HumansAnimalsCells
  15. Rhee J, Ge H, Yang W, Fan M, Handschin C, Cooper M, Lin J, Li C, Spiegelman BM. Partnership of PGC-1alpha and HNF4alpha in the regulation of lipoprotein metabolism. J Biol Chem. 2006 May 26; 281(21):14683-90. PMID: 16574644.
    Citations: 36     Fields:    Translation:AnimalsCells
  16. Handschin C, Lin J, Rhee J, Peyer AK, Chin S, Wu PH, Meyer UA, Spiegelman BM. Nutritional regulation of hepatic heme biosynthesis and porphyria through PGC-1alpha. Cell. 2005 Aug 26; 122(4):505-15. PMID: 16122419.
    Citations: 135     Fields:    Translation:AnimalsCells
  17. Fan M, Rhee J, St-Pierre J, Handschin C, Puigserver P, Lin J, Jäeger S, Erdjument-Bromage H, Tempst P, Spiegelman BM. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev. 2004 Feb 01; 18(3):278-89. PMID: 14744933.
    Citations: 121     Fields:    Translation:AnimalsCells
  18. Yoon JC, Xu G, Deeney JT, Yang SN, Rhee J, Puigserver P, Levens AR, Yang R, Zhang CY, Lowell BB, Berggren PO, Newgard CB, Bonner-Weir S, Weir G, Spiegelman BM. Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell. 2003 Jul; 5(1):73-83. PMID: 12852853.
    Citations: 62     Fields:    Translation:AnimalsCells
  19. Lin J, Tarr PT, Yang R, Rhee J, Puigserver P, Newgard CB, Spiegelman BM. PGC-1beta in the regulation of hepatic glucose and energy metabolism. J Biol Chem. 2003 Aug 15; 278(33):30843-8. PMID: 12807885.
    Citations: 102     Fields:    Translation:AnimalsCells
  20. Handschin C, Rhee J, Lin J, Tarr PT, Spiegelman BM. An autoregulatory loop controls peroxisome proliferator-activated receptor gamma coactivator 1alpha expression in muscle. Proc Natl Acad Sci U S A. 2003 Jun 10; 100(12):7111-6. PMID: 12764228.
    Citations: 278     Fields:    Translation:AnimalsCells
  21. Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM. Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature. 2003 May 29; 423(6939):550-5. PMID: 12754525.
    Citations: 574     Fields:    Translation:AnimalsCells
  22. Rhee J, Inoue Y, Yoon JC, Puigserver P, Fan M, Gonzalez FJ, Spiegelman BM. Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis. Proc Natl Acad Sci U S A. 2003 Apr 01; 100(7):4012-7. PMID: 12651943.
    Citations: 227     Fields:    Translation:AnimalsCells
  23. Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, Krauss S, Mootha VK, Lowell BB, Spiegelman BM. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell. 2001 Nov; 8(5):971-82. PMID: 11741533.
    Citations: 287     Fields:    Translation:HumansAnimalsCells
  24. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, Spiegelman BM. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature. 2001 Sep 13; 413(6852):131-8. PMID: 11557972.
    Citations: 678     Fields:    Translation:AnimalsCells
  25. Skapek SX, Rhee J, Kim PS, Novitch BG, Lassar AB. Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation. Mol Cell Biol. 1996 Dec; 16(12):7043-53. PMID: 8943359.
    Citations: 46     Fields:    Translation:AnimalsCells
  26. Spicer DB, Rhee J, Cheung WL, Lassar AB. Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein Twist. Science. 1996 Jun 07; 272(5267):1476-80. PMID: 8633239.
    Citations: 87     Fields:    Translation:AnimalsCells
  27. Skapek SX, Rhee J, Spicer DB, Lassar AB. Inhibition of myogenic differentiation in proliferating myoblasts by cyclin D1-dependent kinase. Science. 1995 Feb 17; 267(5200):1022-4. PMID: 7863328.
    Citations: 141     Fields:    Translation:AnimalsCells
  28. Halevy O, Novitch BG, Spicer DB, Skapek SX, Rhee J, Hannon GJ, Beach D, Lassar AB. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science. 1995 Feb 17; 267(5200):1018-21. PMID: 7863327.
    Citations: 334     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.