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Kevin M Haigis, Ph.D.

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Mentoring
Available: 09/01/17, Expires: 09/01/22

Overcoming mutational activation of K-Ras is the most pressing issue in medical oncology today. Emerging epidemiological data suggest that the different activating mutations in K-Ras exhibit different clinical behaviors. An unanswered question is whether this has to do with intrinsic biological differences between mutant forms of K-Ras, or some other aspect of cancers with K-Ras mutations. Through large scale bioinformatic analysis, we have found that each K-Ras allele is associated with a distinct group of secondary mutations. This project addresses whether the secondary mutations interact with K-Ras in an allele-specific manner. At a technical level, the project involves engineering cells or primary organoids to express different K-Ras alleles and then performing genetics screens. The major question will be whether each K-Ras allele responds different to perturbation of secondary genes and whether the results of the screen overlap with the genetics of primary cancers.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA246653 (HAIGIS, KEVIN MICHAEL) Jul 1, 2020 - Jun 30, 2025
    NIH/NCI
    Mouse models of Kras-mutant colorectal cancer
    Role: Principal Investigator
  2. R01CA232372 (HAIGIS, KEVIN MICHAEL) Jun 20, 2018 - May 31, 2023
    NIH/NCI
    Tissue-specific genetic interactions in cancer
    Role: Principal Investigator
  3. U01CA215798 (LAUFFENBURGER, DOUGLAS A) Apr 5, 2017 - Mar 31, 2022
    NIH/NCI
    Systems approaches to understanding the relationships between genotype, signaling, and therapeutic efficacy
    Role: Co-Principal Investigator
  4. R01CA195744 (HAIGIS, KEVIN MICHAEL) Dec 15, 2015 - Nov 30, 2018
    NIH/NCI
    Modeling KRAS genetic heterogeneity in mouse models
    Role: Principal Investigator
  5. U01CA199252 (HAIGIS, KEVIN MICHAEL) Sep 25, 2015 - Aug 31, 2020
    NIH/NCI
    A multi-faceted approach to identifying K-Ras synthetic lethal relationships
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Li X, Pritykin Y, Concepcion CP, Lu Y, La Rocca G, Zhang M, King B, Cook PJ, Au YW, Popow O, Paulo JA, Otis HG, Mastroleo C, Ogrodowski P, Schreiner R, Haigis KM, Betel D, Leslie CS, Ventura A. High-Resolution In Vivo Identification of miRNA Targets by Halo-Enhanced Ago2 Pull-Down. Mol Cell. 2020 07 02; 79(1):167-179.e11. PMID: 32497496.
    Citations:    
  2. Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Blood. 2020 May 14; 135(20):1772-1782. PMID: 32219446.
    Citations:    
  3. Ferguson FM, Nabet B, Raghavan S, Liu Y, Leggett AL, Kuljanin M, Kalekar RL, Yang A, He S, Wang J, Ng RWS, Sulahian R, Li L, Poulin EJ, Huang L, Koren J, Dieguez-Martinez N, Espinosa S, Zeng Z, Corona CR, Vasta JD, Ohi R, Sim T, Kim ND, Harshbarger W, Lizcano JM, Robers MB, Muthaswamy S, Lin CY, Look AT, Haigis KM, Mancias JD, Wolpin BM, Aguirre AJ, Hahn WC, Westover KD, Gray NS. Discovery of a selective inhibitor of doublecortin like kinase 1. Nat Chem Biol. 2020 06; 16(6):635-643. PMID: 32251410.
    Citations:    
  4. Strasser SD, Ghazi PC, Starchenko A, Boukhali M, Edwards A, Suarez-Lopez L, Lyons J, Changelian PS, Monahan JB, Jacobsen J, Brubaker DK, Joughin BA, Yaffe MB, Haas W, Lauffenburger DA, Haigis KM. Substrate-based kinase activity inference identifies MK2 as driver of colitis. Integr Biol (Camb). 2019 11 26; 11(7):301-314. PMID: 31617572.
    Citations:    
  5. Brubaker DK, Paulo JA, Sheth S, Poulin EJ, Popow O, Joughin BA, Strasser SD, Starchenko A, Gygi SP, Lauffenburger DA, Haigis KM. Proteogenomic Network Analysis of Context-Specific KRAS Signaling in Mouse-to-Human Cross-Species Translation. Cell Syst. 2019 09 25; 9(3):258-270.e6. PMID: 31521603.
    Citations:    
  6. Johnson CW, Lin YJ, Reid D, Parker J, Pavlopoulos S, Dischinger P, Graveel C, Aguirre AJ, Steensma M, Haigis KM, Mattos C. Isoform-Specific Destabilization of the Active Site Reveals a Molecular Mechanism of Intrinsic Activation of KRas G13D. Cell Rep. 2019 08 06; 28(6):1538-1550.e7. PMID: 31390567.
    Citations:    
  7. Popow O, Paulo JA, Tatham MH, Volk MS, Rojas-Fernandez A, Loyer N, Newton IP, Januschke J, Haigis KM, Näthke I. Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and ß-Catenin-Independent Targets by Proteomics. Mol Cancer Res. 2019 09; 17(9):1828-1841. PMID: 31160382.
    Citations:    
  8. Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM. Tissue-Specific Oncogenic Activity of KRASA146T. Cancer Discov. 2019 06; 9(6):738-755. PMID: 30952657.
    Citations:    
  9. Haigis KM, Cichowski K, Elledge SJ. Tissue-specificity in cancer: The rule, not the exception. Science. 2019 Mar 15; 363(6432):1150-1151. PMID: 30872507.
    Citations:    
  10. Brubaker DK, Proctor EA, Haigis KM, Lauffenburger DA. Computational translation of genomic responses from experimental model systems to humans. PLoS Comput Biol. 2019 01; 15(1):e1006286. PMID: 30629591.
    Citations:    Fields:    
  11. Suarez-Lopez L, Sriram G, Kong YW, Morandell S, Merrick KA, Hernandez Y, Haigis KM, Yaffe MB. MK2 contributes to tumor progression by promoting M2 macrophage polarization and tumor angiogenesis. Proc Natl Acad Sci U S A. 2018 05 01; 115(18):E4236-E4244. PMID: 29666270.
    Citations:    Fields:    Translation:AnimalsCells
  12. Lyons J, Ghazi PC, Starchenko A, Tovaglieri A, Baldwin KR, Poulin EJ, Gierut JJ, Genetti C, Yajnik V, Breault DT, Lauffenburger DA, Haigis KM. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS Biol. 2018 03; 16(3):e2002417. PMID: 29596476.
    Citations:    Fields:    
  13. Lyons J, Brubaker DK, Ghazi PC, Baldwin KR, Edwards A, Boukhali M, Strasser SD, Suarez-Lopez L, Lin YJ, Yajnik V, Kissil JL, Haas W, Lauffenburger DA, Haigis KM. Integrated in vivo multiomics analysis identifies p21-activated kinase signaling as a driver of colitis. Sci Signal. 2018 02 27; 11(519). PMID: 29487189.
    Citations: 1     Fields:    
  14. Lin YJ, Haigis KM. Brother's Keeper: Wild-Type Mutant K-Ras Dimers Limit Oncogenesis. Cell. 2018 02 08; 172(4):645-647. PMID: 29425486.
    Citations:    Fields:    Translation:HumansCells
  15. Haigis KM. KRAS Alleles: The Devil Is in the Detail. Trends Cancer. 2017 10; 3(10):686-697. PMID: 28958387.
    Citations: 3     Fields:    Translation:HumansAnimals
  16. Martin TD, Cook DR, Choi MY, Li MZ, Haigis KM, Elledge SJ. A Role for Mitochondrial Translation in Promotion of Viability in K-Ras Mutant Cells. Cell Rep. 2017 07 11; 20(2):427-438. PMID: 28700943.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  17. Poulin EJ, Haigis KM. No back seat for a progression event-K-RAS as a therapeutic target in CRC. Genes Dev. 2017 02 15; 31(4):333-335. PMID: 28314765.
    Citations:    Fields:    Translation:AnimalsCells
  18. Deshpande V, Konstantinidis IT, Castillo CF, Hezel AF, Haigis KM, Ting DT, Bardeesy N, Goyal L, Zhu AX, Warshaw AL, Lillemoe KD, Ferrone CR. Intra-pancreatic Distal Bile Duct Carcinoma is Morphologically, Genetically, and Clinically Distinct from Pancreatic Ductal Adenocarcinoma. J Gastrointest Surg. 2016 05; 20(5):953-9. PMID: 26956004.
    Citations: 2     Fields:    Translation:Humans
  19. Gierut JJ, Wood LB, Lau KS, Lin YJ, Genetti C, Samatar AA, Lauffenburger DA, Haigis KM. Network-level effects of kinase inhibitors modulate TNF-a-induced apoptosis in the intestinal epithelium. Sci Signal. 2015 Dec 15; 8(407):ra129. PMID: 26671150.
    Citations: 3     Fields:    Translation:Animals
  20. Wood LB, Winslow AR, Proctor EA, McGuone D, Mordes DA, Frosch MP, Hyman BT, Lauffenburger DA, Haigis KM. Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Sci Rep. 2015 Nov 13; 5:16622. PMID: 26564777.
    Citations: 7     Fields:    Translation:HumansCells
  21. Nicolay BN, Danielian PS, Kottakis F, Lapek JD, Sanidas I, Miles WO, Dehnad M, Tschöp K, Gierut JJ, Manning AL, Morris R, Haigis K, Bardeesy N, Lees JA, Haas W, Dyson NJ. Proteomic analysis of pRb loss highlights a signature of decreased mitochondrial oxidative phosphorylation. Genes Dev. 2015 Sep 01; 29(17):1875-89. PMID: 26314710.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  22. Gierut JJ, Lyons J, Shah MS, Genetti C, Breault DT, Haigis KM. Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. Stem Cell Res. 2015 Jul; 15(1):165-71. PMID: 26079371.
    Citations:    Fields:    Translation:AnimalsCells
  23. Bender RH, Haigis KM, Gutmann DH. Activated k-ras, but not h-ras or N-ras, regulates brain neural stem cell proliferation in a raf/rb-dependent manner. Stem Cells. 2015 Jun; 33(6):1998-2010. PMID: 25788415.
    Citations: 5     Fields:    Translation:AnimalsCells
  24. Depeille P, Henricks LM, van de Ven RA, Lemmens E, Wang CY, Matli M, Werb Z, Haigis KM, Donner D, Warren R, Roose JP. RasGRP1 opposes proliferative EGFR-SOS1-Ras signals and restricts intestinal epithelial cell growth. Nat Cell Biol. 2015 Jun; 17(6):804-15. PMID: 26005835.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  25. Tsai FD, Lopes MS, Zhou M, Court H, Ponce O, Fiordalisi JJ, Gierut JJ, Cox AD, Haigis KM, Philips MR. K-Ras4A splice variant is widely expressed in cancer and uses a hybrid membrane-targeting motif. Proc Natl Acad Sci U S A. 2015 Jan 20; 112(3):779-84. PMID: 25561545.
    Citations: 41     Fields:    Translation:HumansCells
  26. Burgess MR, Hwang E, Firestone AJ, Huang T, Xu J, Zuber J, Bohin N, Wen T, Kogan SC, Haigis KM, Sampath D, Lowe S, Shannon K, Li Q. Preclinical efficacy of MEK inhibition in Nras-mutant AML. Blood. 2014 Dec 18; 124(26):3947-55. PMID: 25361812.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  27. Jun HJ, Roy J, Smith TB, Wood LB, Lane K, Woolfenden S, Punko D, Bronson RT, Haigis KM, Breton S, Charest A. ROS1 signaling regulates epithelial differentiation in the epididymis. Endocrinology. 2014 Sep; 155(9):3661-73. PMID: 24971615.
    Citations: 5     Fields:    Translation:AnimalsCells
  28. Imamura Y, Lochhead P, Yamauchi M, Kuchiba A, Qian ZR, Liao X, Nishihara R, Jung S, Wu K, Nosho K, Wang YE, Peng S, Bass AJ, Haigis KM, Meyerhardt JA, Chan AT, Fuchs CS, Ogino S. Analyses of clinicopathological, molecular, and prognostic associations of KRAS codon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review. Mol Cancer. 2014 May 31; 13:135. PMID: 24885062.
    Citations: 48     Fields:    Translation:HumansCells
  29. Gierut JJ, Jacks TE, Haigis KM. Whole-mount X-Gal staining of mouse tissues. Cold Spring Harb Protoc. 2014 Apr 01; 2014(4):417-9. PMID: 24692489.
    Citations: 4     Fields:    Translation:Animals
  30. Gierut JJ, Jacks TE, Haigis KM. Strategies to achieve conditional gene mutation in mice. Cold Spring Harb Protoc. 2014 Apr 01; 2014(4):339-49. PMID: 24692485.
    Citations: 10     Fields:    Translation:Animals
  31. Gierut JJ, Jacks TE, Haigis KM. In vivo delivery of lenti-Cre or adeno-Cre into mice using intranasal instillation. Cold Spring Harb Protoc. 2014 Mar 01; 2014(3):307-9. PMID: 24591689.
    Citations: 1     Fields:    Translation:AnimalsCells
  32. Gierut JJ, Jacks TE, Haigis KM. Producing and concentrating lenti-Cre for mouse infections. Cold Spring Harb Protoc. 2014 Mar 01; 2014(3):304-6. PMID: 24591688.
    Citations: 3     Fields:    Translation:AnimalsCells
  33. Russo AL, Ryan DP, Borger DR, Wo JY, Szymonifka J, Liang WY, Kwak EL, Blaszkowsky LS, Clark JW, Allen JN, Zhu AX, Berger DL, Cusack JC, Mamon HJ, Haigis KM, Hong TS. Mutational and clinical predictors of pathologic complete response in the treatment of locally advanced rectal cancer. J Gastrointest Cancer. 2014 Mar; 45(1):34-9. PMID: 24006244.
    Citations: 9     Fields:    Translation:Humans
  34. Russo AL, Borger DR, Szymonifka J, Ryan DP, Wo JY, Blaszkowsky LS, Kwak EL, Allen JN, Wadlow RC, Zhu AX, Murphy JE, Faris JE, Dias-Santagata D, Haigis KM, Ellisen LW, Iafrate AJ, Hong TS. Mutational analysis and clinical correlation of metastatic colorectal cancer. Cancer. 2014 May 15; 120(10):1482-90. PMID: 24500602.
    Citations: 19     Fields:    Translation:Humans
  35. Kleiman LB, Krebs AM, Kim SY, Hong TS, Haigis KM. Comparative analysis of radiosensitizers for K-RAS mutant rectal cancers. PLoS One. 2013; 8(12):e82982. PMID: 24349411.
    Citations: 5     Fields:    Translation:HumansCells
  36. Lau KS, Schrier SB, Gierut J, Lyons J, Lauffenburger DA, Haigis KM. Network analysis of differential Ras isoform mutation effects on intestinal epithelial responses to TNF-a. Integr Biol (Camb). 2013 Nov; 5(11):1355-65. PMID: 24084984.
    Citations: 8     Fields:    Translation:AnimalsCells
  37. Xu J, Haigis KM, Firestone AJ, McNerney ME, Li Q, Davis E, Chen SC, Nakitandwe J, Downing J, Jacks T, Le Beau MM, Shannon K. Dominant role of oncogene dosage and absence of tumor suppressor activity in Nras-driven hematopoietic transformation. Cancer Discov. 2013 Sep; 3(9):993-1001. PMID: 23733505.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  38. Yang MH, Laurent G, Bause AS, Spang R, German N, Haigis MC, Haigis KM. HDAC6 and SIRT2 regulate the acetylation state and oncogenic activity of mutant K-RAS. Mol Cancer Res. 2013 Sep; 11(9):1072-7. PMID: 23723075.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  39. Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM. Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice. Integr Biol (Camb). 2013 Jul 24; 5(7):940-63. PMID: 23685806.
    Citations: 7     Fields:    Translation:Animals
  40. Cho H, Hashimoto T, Wong E, Hori Y, Wood LB, Zhao L, Haigis KM, Hyman BT, Irimia D. Microfluidic chemotaxis platform for differentiating the roles of soluble and bound amyloid-ß on microglial accumulation. Sci Rep. 2013; 3:1823. PMID: 23665843.
    Citations: 11     Fields:    Translation:HumansCells
  41. Wang Y, Velho S, Vakiani E, Peng S, Bass AJ, Chu GC, Gierut J, Bugni JM, Der CJ, Philips M, Solit DB, Haigis KM. Mutant N-RAS protects colorectal cancer cells from stress-induced apoptosis and contributes to cancer development and progression. Cancer Discov. 2013 Mar; 3(3):294-307. PMID: 23274911.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  42. Mitra D, Luo X, Morgan A, Wang J, Hoang MP, Lo J, Guerrero CR, Lennerz JK, Mihm MC, Wargo JA, Robinson KC, Devi SP, Vanover JC, D'Orazio JA, McMahon M, Bosenberg MW, Haigis KM, Haber DA, Wang Y, Fisher DE. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature. 2012 Nov 15; 491(7424):449-53. PMID: 23123854.
    Citations: 101     Fields:    Translation:AnimalsCells
  43. Lau KS, Cortez-Retamozo V, Philips SR, Pittet MJ, Lauffenburger DA, Haigis KM. Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-a-induced apoptosis in the intestinal epithelium. PLoS Biol. 2012; 10(9):e1001393. PMID: 23055830.
    Citations: 29     Fields:    Translation:AnimalsCells
  44. Lau KS, Zhang T, Kendall KR, Lauffenburger D, Gray NS, Haigis KM. BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner. PLoS One. 2012; 7(7):e41343. PMID: 22815993.
    Citations: 5     Fields:    Translation:HumansCells
  45. Imamura Y, Morikawa T, Liao X, Lochhead P, Kuchiba A, Yamauchi M, Qian ZR, Nishihara R, Meyerhardt JA, Haigis KM, Fuchs CS, Ogino S. Specific mutations in KRAS codons 12 and 13, and patient prognosis in 1075 BRAF wild-type colorectal cancers. Clin Cancer Res. 2012 Sep 01; 18(17):4753-63. PMID: 22753589.
    Citations: 77     Fields:    Translation:HumansCells
  46. Yang MH, Nickerson S, Kim ET, Liot C, Laurent G, Spang R, Philips MR, Shan Y, Shaw DE, Bar-Sagi D, Haigis MC, Haigis KM. Regulation of RAS oncogenicity by acetylation. Proc Natl Acad Sci U S A. 2012 Jul 03; 109(27):10843-8. PMID: 22711838.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  47. Powell AE, Wang Y, Li Y, Poulin EJ, Means AL, Washington MK, Higginbotham JN, Juchheim A, Prasad N, Levy SE, Guo Y, Shyr Y, Aronow BJ, Haigis KM, Franklin JL, Coffey RJ. The pan-ErbB negative regulator Lrig1 is an intestinal stem cell marker that functions as a tumor suppressor. Cell. 2012 Mar 30; 149(1):146-58. PMID: 22464327.
    Citations: 191     Fields:    Translation:HumansAnimalsCells
  48. Hong TS, Clark JW, Haigis KM. Cancers of the colon and rectum: identical or fraternal twins? Cancer Discov. 2012 Feb; 2(2):117-21. PMID: 22585856.
    Citations: 7     Fields:    Translation:Humans
  49. Ahearn IM, Haigis K, Bar-Sagi D, Philips MR. Regulating the regulator: post-translational modification of RAS. Nat Rev Mol Cell Biol. 2011 Dec 22; 13(1):39-51. PMID: 22189424.
    Citations: 148     Fields:    Translation:HumansAnimalsCells
  50. Xu J, Hedberg C, Dekker FJ, Li Q, Haigis KM, Hwang E, Waldmann H, Shannon K. Inhibiting the palmitoylation/depalmitoylation cycle selectively reduces the growth of hematopoietic cells expressing oncogenic Nras. Blood. 2012 Jan 26; 119(4):1032-5. PMID: 22144181.
    Citations: 23     Fields:    Translation:AnimalsCells
  51. Velho S, Haigis KM. Regulation of homeostasis and oncogenesis in the intestinal epithelium by Ras. Exp Cell Res. 2011 Nov 15; 317(19):2732-9. PMID: 21741971.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  52. Lau KS, Juchheim AM, Cavaliere KR, Philips SR, Lauffenburger DA, Haigis KM. In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-a-induced apoptosis and proliferation by MAPKs. Sci Signal. 2011 Mar 22; 4(165):ra16. PMID: 21427409.
    Citations: 42     Fields:    Translation:AnimalsCells
  53. Haigis KM, Sweet-Cordero A. New insights into oncogenic stress. Nat Genet. 2011 Mar; 43(3):177-8. PMID: 21350495.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  54. Li Q, Haigis KM, McDaniel A, Harding-Theobald E, Kogan SC, Akagi K, Wong JC, Braun BS, Wolff L, Jacks T, Shannon K. Hematopoiesis and leukemogenesis in mice expressing oncogenic NrasG12D from the endogenous locus. Blood. 2011 Feb 10; 117(6):2022-32. PMID: 21163920.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  55. Tanaka N, Huttenhower C, Nosho K, Baba Y, Shima K, Quackenbush J, Haigis KM, Giovannucci E, Fuchs CS, Ogino S. Novel application of structural equation modeling to correlation structure analysis of CpG island methylation in colorectal cancer. Am J Pathol. 2010 Dec; 177(6):2731-40. PMID: 21037082.
    Citations: 19     Fields:    Translation:HumansCells
  56. Irahara N, Baba Y, Nosho K, Shima K, Yan L, Dias-Santagata D, Iafrate AJ, Fuchs CS, Haigis KM, Ogino S. NRAS mutations are rare in colorectal cancer. Diagn Mol Pathol. 2010 Sep; 19(3):157-63. PMID: 20736745.
    Citations: 59     Fields:    Translation:HumansCells
  57. Kreeger PK, Wang Y, Haigis KM, Lauffenburger DA. Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation. Integr Biol (Camb). 2010 Apr; 2(4):202-8. PMID: 20473400.
    Citations: 8     Fields:    Translation:HumansCells
  58. Kirsch DG, Santiago PM, di Tomaso E, Sullivan JM, Hou WS, Dayton T, Jeffords LB, Sodha P, Mercer KL, Cohen R, Takeuchi O, Korsmeyer SJ, Bronson RT, Kim CF, Haigis KM, Jain RK, Jacks T. p53 controls radiation-induced gastrointestinal syndrome in mice independent of apoptosis. Science. 2010 Jan 29; 327(5965):593-6. PMID: 20019247.
    Citations: 87     Fields:    Translation:AnimalsCellsPHPublic Health
  59. Cheung AF, Carter AM, Kostova KK, Woodruff JF, Crowley D, Bronson RT, Haigis KM, Jacks T. Complete deletion of Apc results in severe polyposis in mice. Oncogene. 2010 Mar 25; 29(12):1857-64. PMID: 20010873.
    Citations: 25     Fields:    Translation:HumansAnimals
  60. Lau KS, Haigis KM. Non-redundancy within the RAS oncogene family: insights into mutational disparities in cancer. Mol Cells. 2009 Oct 31; 28(4):315-20. PMID: 19812895.
    Citations: 21     Fields:    Translation:Humans
  61. Kreeger PK, Mandhana R, Alford SK, Haigis KM, Lauffenburger DA. RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects. Cancer Res. 2009 Oct 15; 69(20):8191-9. PMID: 19789336.
    Citations: 21     Fields:    Translation:HumansCells
  62. Matharu KS, Mizoguchi E, Cotoner CA, Nguyen DD, Mingle B, Iweala OI, McBee ME, Stefka AT, Prioult G, Haigis KM, Bhan AK, Snapper SB, Murakami H, Schauer DB, Reinecker HC, Mizoguchi A, Nagler CR. Toll-like receptor 4-mediated regulation of spontaneous Helicobacter-dependent colitis in IL-10-deficient mice. Gastroenterology. 2009 Oct; 137(4):1380-90.e1-3. PMID: 19596011.
    Citations: 29     Fields:    Translation:AnimalsCells
  63. Ianari A, Natale T, Calo E, Ferretti E, Alesse E, Screpanti I, Haigis K, Gulino A, Lees JA. Proapoptotic function of the retinoblastoma tumor suppressor protein. Cancer Cell. 2009 Mar 03; 15(3):184-94. PMID: 19249677.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  64. Morris EJ, Ji JY, Yang F, Di Stefano L, Herr A, Moon NS, Kwon EJ, Haigis KM, Näär AM, Dyson NJ. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature. 2008 Sep 25; 455(7212):552-6. PMID: 18794899.
    Citations: 107     Fields:    Translation:HumansCells
  65. Haigis KM, Kendall KR, Wang Y, Cheung A, Haigis MC, Glickman JN, Niwa-Kawakita M, Sweet-Cordero A, Sebolt-Leopold J, Shannon KM, Settleman J, Giovannini M, Jacks T. Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon. Nat Genet. 2008 May; 40(5):600-8. PMID: 18372904.
    Citations: 209     Fields:    Translation:HumansAnimalsCells
  66. Kissil JL, Walmsley MJ, Hanlon L, Haigis KM, Bender Kim CF, Sweet-Cordero A, Eckman MS, Tuveson DA, Capobianco AJ, Tybulewicz VL, Jacks T. Requirement for Rac1 in a K-ras induced lung cancer in the mouse. Cancer Res. 2007 Sep 01; 67(17):8089-94. PMID: 17804720.
    Citations: 67     Fields:    Translation:AnimalsCells
  67. Poutahidis T, Haigis KM, Rao VP, Nambiar PR, Taylor CL, Ge Z, Watanabe K, Davidson A, Horwitz BH, Fox JG, Erdman SE. Rapid reversal of interleukin-6-dependent epithelial invasion in a mouse model of microbially induced colon carcinoma. Carcinogenesis. 2007 Dec; 28(12):2614-23. PMID: 17724375.
    Citations: 34     Fields:    Translation:AnimalsCells
  68. Kwong LN, Weiss KR, Haigis KM, Dove WF. Atm is a negative regulator of intestinal neoplasia. Oncogene. 2008 Feb 07; 27(7):1013-8. PMID: 17700532.
    Citations: 9     Fields:    Translation:Animals
  69. Haigis KM, Wistuba II, Kurie JM. Lung premalignancy induced by mutant B-Raf, what is thy fate? To senesce or not to senesce, that is the question. Genes Dev. 2007 Feb 15; 21(4):361-6. PMID: 17322395.
    Citations: 5     Fields:    Translation:HumansAnimals
  70. Kaiser S, Park YK, Franklin JL, Halberg RB, Yu M, Jessen WJ, Freudenberg J, Chen X, Haigis K, Jegga AG, Kong S, Sakthivel B, Xu H, Reichling T, Azhar M, Boivin GP, Roberts RB, Bissahoyo AC, Gonzales F, Bloom GC, Eschrich S, Carter SL, Aronow JE, Kleimeyer J, Kleimeyer M, Ramaswamy V, Settle SH, Boone B, Levy S, Graff JM, Doetschman T, Groden J, Dove WF, Threadgill DW, Yeatman TJ, Coffey RJ, Aronow BJ. Transcriptional recapitulation and subversion of embryonic colon development by mouse colon tumor models and human colon cancer. Genome Biol. 2007; 8(7):R131. PMID: 17615082.
    Citations: 128     Fields:    Translation:HumansAnimalsCells
  71. Keller JW, Haigis KM, Franklin JL, Whitehead RH, Jacks T, Coffey RJ. Oncogenic K-RAS subverts the antiapoptotic role of N-RAS and alters modulation of the N-RAS:gelsolin complex. Oncogene. 2007 May 10; 26(21):3051-9. PMID: 17130841.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  72. Haigis MC, Mostoslavsky R, Haigis KM, Fahie K, Christodoulou DC, Murphy AJ, Valenzuela DM, Yancopoulos GD, Karow M, Blander G, Wolberger C, Prolla TA, Weindruch R, Alt FW, Guarente L. SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell. 2006 Sep 08; 126(5):941-54. PMID: 16959573.
    Citations: 323     Fields:    Translation:HumansAnimalsCells
  73. Haigis K, Sage J, Glickman J, Shafer S, Jacks T. The related retinoblastoma (pRb) and p130 proteins cooperate to regulate homeostasis in the intestinal epithelium. J Biol Chem. 2006 Jan 06; 281(1):638-47. PMID: 16258171.
    Citations: 43     Fields:    Translation:Animals
  74. Haigis KM, Hoff PD, White A, Shoemaker AR, Halberg RB, Dove WF. Tumor regionality in the mouse intestine reflects the mechanism of loss of Apc function. Proc Natl Acad Sci U S A. 2004 Jun 29; 101(26):9769-73. PMID: 15210940.
    Citations: 24     Fields:    Translation:Animals
  75. Haigis KM, Dove WF. A Robertsonian translocation suppresses a somatic recombination pathway to loss of heterozygosity. Nat Genet. 2003 Jan; 33(1):33-9. PMID: 12447373.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  76. Haigis KM, Caya JG, Reichelderfer M, Dove WF. Intestinal adenomas can develop with a stable karyotype and stable microsatellites. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8927-31. PMID: 12060718.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  77. Shoemaker AR, Haigis KM, Baker SM, Dudley S, Liskay RM, Dove WF. Mlh1 deficiency enhances several phenotypes of Apc(Min)/+ mice. Oncogene. 2000 May 25; 19(23):2774-9. PMID: 10851078.
    Citations: 14     Fields:    Translation:Animals
  78. Davis TM, Yu H, Haigis KM, McGowan PJ. Template mixing: a method of enhancing detection and interpretation of codominant RAPD markers. Theor Appl Genet. 1995 Sep; 91(4):582-8. PMID: 24169884.
    Citations: 6     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.