Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Bradley Theodore Hyman, M.D., Ph.D.

Co-Author

This page shows the publications co-authored by Bradley Hyman and Matthew Frosch.
Connection Strength

7.739
  1. Impact of Sterilization Methods on the Seeding Ability of Human Tau Proteopathic Seeds. J Neuropathol Exp Neurol. 2021 Sep 08.
    View in: PubMed
    Score: 0.248
  2. Cytoplasmic Mislocalization of RNA Polymerase II Subunit RPB1 in Alzheimer Disease Is Linked to Pathologic Tau. J Neuropathol Exp Neurol. 2021 Jun 04; 80(6):530-540.
    View in: PubMed
    Score: 0.243
  3. Continuous Monitoring of Tau-Induced Neurotoxicity in Patient-Derived iPSC-Neurons. J Neurosci. 2021 May 12; 41(19):4335-4348.
    View in: PubMed
    Score: 0.241
  4. Impairment of visual cortical plasticity by amyloid-beta species. Neurobiol Dis. 2021 07; 154:105344.
    View in: PubMed
    Score: 0.240
  5. Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nat Med. 2021 Feb; 27(2):356.
    View in: PubMed
    Score: 0.238
  6. Risk of Transmissibility From Neurodegenerative Disease-Associated Proteins: Experimental Knowns and Unknowns. J Neuropathol Exp Neurol. 2020 11 01; 79(11):1141-1146.
    View in: PubMed
    Score: 0.234
  7. Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nat Med. 2020 08; 26(8):1256-1263.
    View in: PubMed
    Score: 0.228
  8. The Alzheimer Disease-Causing Presenilin-1 L435F Mutation Causes Increased Production of Soluble Aß43 Species in Patient-Derived iPSC-Neurons, Closely Mimicking Matched Patient Brain Tissue. J Neuropathol Exp Neurol. 2020 06 01; 79(6):592-604.
    View in: PubMed
    Score: 0.227
  9. Tau reduction in the presence of amyloid-ß prevents tau pathology and neuronal death in vivo. Brain. 2018 07 01; 141(7):2194-2212.
    View in: PubMed
    Score: 0.199
  10. Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain. Front Neurosci. 2018; 12:267.
    View in: PubMed
    Score: 0.196
  11. Activity-Dependent Dysfunction in Visual and Olfactory Sensory Systems in Mouse Models of Down Syndrome. J Neurosci. 2017 10 11; 37(41):9880-9888.
    View in: PubMed
    Score: 0.188
  12. Enhanced Tau Aggregation in the Presence of Amyloid ß. Am J Pathol. 2017 Jul; 187(7):1601-1612.
    View in: PubMed
    Score: 0.184
  13. Seed-competent high-molecular-weight tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients. Ann Neurol. 2016 09; 80(3):355-67.
    View in: PubMed
    Score: 0.174
  14. Thal Amyloid Stages Do Not Significantly Impact the Correlation Between Neuropathological Change and Cognition in the Alzheimer Disease Continuum. J Neuropathol Exp Neurol. 2016 06; 75(6):516-26.
    View in: PubMed
    Score: 0.171
  15. Plaque-Associated Local Toxicity Increases over the Clinical Course of Alzheimer Disease. Am J Pathol. 2016 Feb; 186(2):375-84.
    View in: PubMed
    Score: 0.166
  16. Neuronal uptake and propagation of a rare phosphorylated high-molecular-weight tau derived from Alzheimer's disease brain. Nat Commun. 2015 Oct 13; 6:8490.
    View in: PubMed
    Score: 0.165
  17. Multisite assessment of NIA-AA guidelines for the neuropathologic evaluation of Alzheimer's disease. Alzheimers Dement. 2016 Feb; 12(2):164-169.
    View in: PubMed
    Score: 0.163
  18. Frequent and symmetric deposition of misfolded tau oligomers within presynaptic and postsynaptic terminals in Alzheimer's disease. Acta Neuropathol Commun. 2014 Oct 21; 2:146.
    View in: PubMed
    Score: 0.154
  19. Mild to moderate Alzheimer dementia with insufficient neuropathological changes. Ann Neurol. 2014 Apr; 75(4):597-601.
    View in: PubMed
    Score: 0.148
  20. Examination of the clinicopathologic continuum of Alzheimer disease in the autopsy cohort of the National Alzheimer Coordinating Center. J Neuropathol Exp Neurol. 2013 Dec; 72(12):1182-92.
    View in: PubMed
    Score: 0.145
  21. Differential relationships of reactive astrocytes and microglia to fibrillar amyloid deposits in Alzheimer disease. J Neuropathol Exp Neurol. 2013 Jun; 72(6):462-71.
    View in: PubMed
    Score: 0.140
  22. A phenotypic change but not proliferation underlies glial responses in Alzheimer disease. Am J Pathol. 2013 Jun; 182(6):2332-44.
    View in: PubMed
    Score: 0.139
  23. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid ß peptide. J Neurosci. 2012 Oct 24; 32(43):15181-92.
    View in: PubMed
    Score: 0.134
  24. The synaptic accumulation of hyperphosphorylated tau oligomers in Alzheimer disease is associated with dysfunction of the ubiquitin-proteasome system. Am J Pathol. 2012 Oct; 181(4):1426-35.
    View in: PubMed
    Score: 0.132
  25. Stable size distribution of amyloid plaques over the course of Alzheimer disease. J Neuropathol Exp Neurol. 2012 Aug; 71(8):694-701.
    View in: PubMed
    Score: 0.132
  26. Synaptic plasticity defect following visual deprivation in Alzheimer's disease model transgenic mice. J Neurosci. 2012 Jun 06; 32(23):8004-11.
    View in: PubMed
    Score: 0.130
  27. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease. Alzheimers Dement. 2012 Jan; 8(1):1-13.
    View in: PubMed
    Score: 0.127
  28. Neuropathological alterations in Alzheimer disease. Cold Spring Harb Perspect Med. 2011 Sep; 1(1):a006189.
    View in: PubMed
    Score: 0.124
  29. Reactive glia not only associates with plaques but also parallels tangles in Alzheimer's disease. Am J Pathol. 2011 Sep; 179(3):1373-84.
    View in: PubMed
    Score: 0.123
  30. Beneficial effect of human anti-amyloid-beta active immunization on neurite morphology and tau pathology. Brain. 2010 May; 133(Pt 5):1312-27.
    View in: PubMed
    Score: 0.112
  31. Preservation of neuronal number despite age-related cortical brain atrophy in elderly subjects without Alzheimer disease. J Neuropathol Exp Neurol. 2008 Dec; 67(12):1205-12.
    View in: PubMed
    Score: 0.102
  32. TAR-DNA binding protein 43 in Pick disease. J Neuropathol Exp Neurol. 2008 Jan; 67(1):62-7.
    View in: PubMed
    Score: 0.096
  33. Increase in the relative expression of tau with four microtubule binding repeat regions in frontotemporal lobar degeneration and progressive supranuclear palsy brains. Acta Neuropathol. 2007 Nov; 114(5):471-9.
    View in: PubMed
    Score: 0.094
  34. Expression of APP pathway mRNAs and proteins in Alzheimer's disease. Brain Res. 2007 Aug 03; 1161:116-23.
    View in: PubMed
    Score: 0.092
  35. No alteration in tau exon 10 alternative splicing in tangle-bearing neurons of the Alzheimer's disease brain. Acta Neuropathol. 2006 Oct; 112(4):439-49.
    View in: PubMed
    Score: 0.086
  36. Coordinated expression of caspase 8, 3 and 7 mRNA in temporal cortex of Alzheimer disease: relationship to formic acid extractable abeta42 levels. J Neuropathol Exp Neurol. 2006 May; 65(5):508-15.
    View in: PubMed
    Score: 0.085
  37. Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies. Acta Neuropathol. 2006 Feb; 111(2):101-8.
    View in: PubMed
    Score: 0.084
  38. Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease. J Neuropathol Exp Neurol. 2005 Jul; 64(7):588-94.
    View in: PubMed
    Score: 0.081
  39. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. J Neurosci. 2005 Mar 16; 25(11):3009-17.
    View in: PubMed
    Score: 0.079
  40. Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. Nat Med. 2004 Oct; 10(10):1065-6.
    View in: PubMed
    Score: 0.077
  41. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 2002 Sep; 61(9):797-805.
    View in: PubMed
    Score: 0.066
  42. Genome-encoded cytoplasmic double-stranded RNAs, found in C9ORF72 ALS-FTD brain, propagate neuronal loss. Sci Transl Med. 2021 07 07; 13(601).
    View in: PubMed
    Score: 0.061
  43. Kinetics of tau aggregation reveals patient-specific tau characteristics among Alzheimer's cases. Brain Commun. 2021; 3(2):fcab096.
    View in: PubMed
    Score: 0.060
  44. Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease. Front Neurol. 2020; 11:575953.
    View in: PubMed
    Score: 0.058
  45. Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat Commun. 2020 02 03; 11(1):667.
    View in: PubMed
    Score: 0.055
  46. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing. Nat Genet. 2019 Sep; 51(9):1423-1424.
    View in: PubMed
    Score: 0.054
  47. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Brain Res Mol Brain Res. 1999 Jun 08; 69(2):273-80.
    View in: PubMed
    Score: 0.053
  48. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing. Nat Genet. 2019 03; 51(3):414-430.
    View in: PubMed
    Score: 0.052
  49. Different tau species lead to heterogeneous tau pathology propagation and misfolding. Acta Neuropathol Commun. 2018 11 29; 6(1):132.
    View in: PubMed
    Score: 0.051
  50. Synaptic phosphorylated a-synuclein in dementia with Lewy bodies. Brain. 2017 Dec 01; 140(12):3204-3214.
    View in: PubMed
    Score: 0.048
  51. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017 09; 49(9):1373-1384.
    View in: PubMed
    Score: 0.046
  52. Absence of Alzheimer Disease Neuropathologic Changes in Eyes of Subjects With Alzheimer Disease. J Neuropathol Exp Neurol. 2017 May 01; 76(5):376-383.
    View in: PubMed
    Score: 0.046
  53. Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro. Am J Pathol. 2017 Jun; 187(6):1399-1412.
    View in: PubMed
    Score: 0.046
  54. Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies. Ann Neurol. 2017 Jan; 81(1):117-128.
    View in: PubMed
    Score: 0.045
  55. Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue. Sci Rep. 2016 09 15; 6:33079.
    View in: PubMed
    Score: 0.044
  56. Amyloid-beta oligomerization is associated with the generation of a typical peptide fragment fingerprint. Alzheimers Dement. 2016 09; 12(9):996-1013.
    View in: PubMed
    Score: 0.043
  57. Identification of neurotoxic cytokines by profiling Alzheimer's disease tissues and neuron culture viability screening. Sci Rep. 2015 Nov 13; 5:16622.
    View in: PubMed
    Score: 0.041
  58. Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue. Ann Neurol. 2015 Nov; 78(5):787-800.
    View in: PubMed
    Score: 0.041
  59. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16.
    View in: PubMed
    Score: 0.039
  60. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404.
    View in: PubMed
    Score: 0.039
  61. Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias. PLoS Genet. 2014 Sep; 10(9):e1004606.
    View in: PubMed
    Score: 0.038
  62. A novel GRN mutation (GRN c.708+6_+9delTGAG) in frontotemporal lobar degeneration with TDP-43-positive inclusions: clinicopathologic report of 6 cases. J Neuropathol Exp Neurol. 2014 May; 73(5):467-73.
    View in: PubMed
    Score: 0.037
  63. Studying synapses in human brain with array tomography and electron microscopy. Nat Protoc. 2013; 8(7):1366-80.
    View in: PubMed
    Score: 0.035
  64. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012 Dec; 44(12):1349-54.
    View in: PubMed
    Score: 0.034
  65. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8.
    View in: PubMed
    Score: 0.033
  66. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-ß. Brain. 2012 Jul; 135(Pt 7):2155-68.
    View in: PubMed
    Score: 0.033
  67. Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. J Neuropathol Exp Neurol. 2012 May; 71(5):362-81.
    View in: PubMed
    Score: 0.032
  68. National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach. Acta Neuropathol. 2012 Jan; 123(1):1-11.
    View in: PubMed
    Score: 0.031
  69. Tau accumulation causes mitochondrial distribution deficits in neurons in a mouse model of tauopathy and in human Alzheimer's disease brain. Am J Pathol. 2011 Oct; 179(4):2071-82.
    View in: PubMed
    Score: 0.031
  70. Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup. Alzheimers Dement. 2011 Jul; 7(4):367-85.
    View in: PubMed
    Score: 0.031
  71. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41.
    View in: PubMed
    Score: 0.030
  72. Novel progranulin mutation detected in 2 patients with FTLD. Alzheimer Dis Assoc Disord. 2011 Apr-Jun; 25(2):173-8.
    View in: PubMed
    Score: 0.030
  73. No evidence of PGRN or MAPT gene dosage alterations in a collection of patients with frontotemporal lobar degeneration. Dement Geriatr Cogn Disord. 2009; 28(5):471-5.
    View in: PubMed
    Score: 0.027
  74. Predicting the location of entorhinal cortex from MRI. Neuroimage. 2009 Aug 01; 47(1):8-17.
    View in: PubMed
    Score: 0.026
  75. Adult onset leukodystrophy with neuroaxonal spheroids: clinical, neuroimaging and neuropathologic observations. Brain Pathol. 2009 Jan; 19(1):39-47.
    View in: PubMed
    Score: 0.024
  76. Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain. 2007 Sep; 130(Pt 9):2310-9.
    View in: PubMed
    Score: 0.023
  77. Plasma Abeta levels do not reflect brain Abeta levels. J Neuropathol Exp Neurol. 2007 Apr; 66(4):264-71.
    View in: PubMed
    Score: 0.023
  78. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol. 2007 Mar; 64(3):431-4.
    View in: PubMed
    Score: 0.023
  79. Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neurosci. 2006 Jan 11; 26(2):365-71.
    View in: PubMed
    Score: 0.021
  80. Alpha-synuclein and chaperones in dementia with Lewy bodies. J Neuropathol Exp Neurol. 2005 Dec; 64(12):1058-66.
    View in: PubMed
    Score: 0.021
  81. Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain. Neurology. 2004 Mar 23; 62(6):925-31.
    View in: PubMed
    Score: 0.018
  82. Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies. Am J Pathol. 2002 May; 160(5):1655-67.
    View in: PubMed
    Score: 0.016
  83. A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorg Med Chem Lett. 2002 Feb 11; 12(3):295-8.
    View in: PubMed
    Score: 0.016
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.