Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Bradley Theodore Hyman, M.D., Ph.D.

Co-Author

This page shows the publications co-authored by Bradley Hyman and Rudolph Tanzi.
Connection Strength

4.319
  1. Effects of Species-Specific Genetics on Alzheimer's Mouse Models. Neuron. 2019 02 06; 101(3):351-352.
    View in: PubMed
    Score: 0.835
  2. Author Correction: Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nat Med. 2021 Feb; 27(2):356.
    View in: PubMed
    Score: 0.240
  3. Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nat Med. 2020 08; 26(8):1256-1263.
    View in: PubMed
    Score: 0.230
  4. Alternatives to amyloid for Alzheimer's disease therapies-a symposium report. Ann N Y Acad Sci. 2020 09; 1475(1):3-14.
    View in: PubMed
    Score: 0.229
  5. Molecular epidemiology of Alzheimer's disease. N Engl J Med. 1995 Nov 09; 333(19):1283-4.
    View in: PubMed
    Score: 0.167
  6. Massachusetts Alzheimer's Disease Research Center: progress and challenges. Alzheimers Dement. 2015 Oct; 11(10):1241-5.
    View in: PubMed
    Score: 0.164
  7. Nonisotopic in situ hybridization of amyloid beta protein precursor in Alzheimer's disease: expression in neurofibrillary tangle bearing neurons and in the microenvironment surrounding senile plaques. Brain Res Mol Brain Res. 1993 May; 18(3):253-8.
    View in: PubMed
    Score: 0.140
  8. Cellular specificity and regional distribution of amyloid beta protein precursor alternative transcripts are unaltered in Alzheimer hippocampal formation. Brain Res Mol Brain Res. 1993 May; 18(3):246-52.
    View in: PubMed
    Score: 0.140
  9. Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron. 2013 May 22; 78(4):631-43.
    View in: PubMed
    Score: 0.140
  10. Amyloid, dementia and Alzheimer's disease. Curr Opin Neurol Neurosurg. 1992 Feb; 5(1):88-93.
    View in: PubMed
    Score: 0.128
  11. Alzheimer's mutation. Nature. 1991 Apr 18; 350(6319):564.
    View in: PubMed
    Score: 0.122
  12. Studies of amyloid beta-protein precursor expression in Alzheimer's disease. Ann N Y Acad Sci. 1991; 640:149-54.
    View in: PubMed
    Score: 0.119
  13. Effects of ubiquilin 1 on the unfolded protein response. J Mol Neurosci. 2009 May; 38(1):19-30.
    View in: PubMed
    Score: 0.102
  14. Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families. J Biol Chem. 2007 Mar 16; 282(11):7825-32.
    View in: PubMed
    Score: 0.091
  15. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem. 2006 Oct 27; 281(43):32240-53.
    View in: PubMed
    Score: 0.088
  16. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation. J Neurochem. 2005 Oct; 95(2):446-56.
    View in: PubMed
    Score: 0.082
  17. Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med. 2005 Mar 03; 352(9):884-94.
    View in: PubMed
    Score: 0.079
  18. Autoantibodies to redox-modified oligomeric Abeta are attenuated in the plasma of Alzheimer's disease patients. J Biol Chem. 2005 Apr 29; 280(17):17458-63.
    View in: PubMed
    Score: 0.079
  19. Association of membrane-bound amyloid precursor protein APP with the apolipoprotein E receptor LRP. Brain Res Mol Brain Res. 2001 Mar 05; 87(2):238-45.
    View in: PubMed
    Score: 0.060
  20. No evidence for genetic association or linkage of the cathepsin D (CTSD) exon 2 polymorphism and Alzheimer disease. Ann Neurol. 2001 Jan; 49(1):114-6.
    View in: PubMed
    Score: 0.060
  21. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing. Nat Genet. 2019 Sep; 51(9):1423-1424.
    View in: PubMed
    Score: 0.054
  22. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aß, tau, immunity and lipid processing. Nat Genet. 2019 03; 51(3):414-430.
    View in: PubMed
    Score: 0.052
  23. Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease. Hum Mol Genet. 1998 Nov; 7(12):1953-6.
    View in: PubMed
    Score: 0.051
  24. Immunohistochemical and in situ analysis of amyloid precursor-like protein-1 and amyloid precursor-like protein-2 expression in Alzheimer disease and aged control brains. Brain Res. 1998 Aug 31; 804(1):45-51.
    View in: PubMed
    Score: 0.051
  25. Alpha-2 macroglobulin is genetically associated with Alzheimer disease. Nat Genet. 1998 Aug; 19(4):357-60.
    View in: PubMed
    Score: 0.050
  26. Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease. J Neurol Sci. 1998 Jun 11; 158(1):15-23.
    View in: PubMed
    Score: 0.050
  27. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nat Genet. 2017 09; 49(9):1373-1384.
    View in: PubMed
    Score: 0.047
  28. A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes. Ann Neurol. 1997 Jun; 41(6):809-13.
    View in: PubMed
    Score: 0.046
  29. Developmental regulation of presenilin mRNA expression parallels notch expression. J Neuropathol Exp Neurol. 1997 Jan; 56(1):40-4.
    View in: PubMed
    Score: 0.045
  30. In situ hybridization analysis of presenilin 1 mRNA in Alzheimer disease and in lesioned rat brain. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):14020-4.
    View in: PubMed
    Score: 0.045
  31. Characterization of the precursor protein of the non-A beta component of senile plaques (NACP) in the human central nervous system. J Neuropathol Exp Neurol. 1996 Aug; 55(8):889-95.
    View in: PubMed
    Score: 0.044
  32. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. JAMA Neurol. 2015 Feb; 72(2):209-16.
    View in: PubMed
    Score: 0.040
  33. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. JAMA Neurol. 2014 Nov; 71(11):1394-404.
    View in: PubMed
    Score: 0.039
  34. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid beta protein precursor. Nat Genet. 1993 Sep; 5(1):95-100.
    View in: PubMed
    Score: 0.036
  35. Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis. Nat Genet. 2012 Dec; 44(12):1349-54.
    View in: PubMed
    Score: 0.034
  36. Assessment of amyloid beta-protein precursor gene mutations in a large set of familial and sporadic Alzheimer disease cases. Am J Hum Genet. 1992 Aug; 51(2):273-82.
    View in: PubMed
    Score: 0.033
  37. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 2012 Jul 17; 79(3):221-8.
    View in: PubMed
    Score: 0.033
  38. Kunitz protease inhibitor-containing amyloid beta protein precursor immunoreactivity in Alzheimer's disease. J Neuropathol Exp Neurol. 1992 Jan; 51(1):76-83.
    View in: PubMed
    Score: 0.032
  39. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011 May; 43(5):436-41.
    View in: PubMed
    Score: 0.030
  40. Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic. 2011 Mar; 12(3):330-48.
    View in: PubMed
    Score: 0.030
  41. The Alzheimer's disease-associated amyloid beta-protein is an antimicrobial peptide. PLoS One. 2010 Mar 03; 5(3):e9505.
    View in: PubMed
    Score: 0.028
  42. Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader. J Biol Chem. 2006 Sep 08; 281(36):26400-7.
    View in: PubMed
    Score: 0.022
  43. BACE is degraded via the lysosomal pathway. J Biol Chem. 2005 Sep 16; 280(37):32499-504.
    View in: PubMed
    Score: 0.020
  44. Low-density lipoprotein receptor-related protein levels and endocytic function are reduced by overexpression of the FE65 adaptor protein, FE65L1. J Neurochem. 2002 Aug; 82(4):755-62.
    View in: PubMed
    Score: 0.017
  45. MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology. 2002 Apr 23; 58(8):1188-96.
    View in: PubMed
    Score: 0.016
  46. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol. 2001 Oct; 3(10):905-12.
    View in: PubMed
    Score: 0.016
  47. Evidence against association of the FE65 gene (APBB1) intron 13 polymorphism in Alzheimer's patients. Neurosci Lett. 2000 Dec 15; 296(1):17-20.
    View in: PubMed
    Score: 0.015
  48. Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease. Ann Neurol. 2000 Apr; 47(4):430-9.
    View in: PubMed
    Score: 0.014
  49. Modulation of beta-amyloid precursor protein processing by the low density lipoprotein receptor-related protein (LRP). Evidence that LRP contributes to the pathogenesis of Alzheimer's disease. J Biol Chem. 2000 Mar 10; 275(10):7410-5.
    View in: PubMed
    Score: 0.014
  50. Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells. Nat Med. 1996 Feb; 2(2):224-9.
    View in: PubMed
    Score: 0.011
  51. LDL receptor-related protein, a multifunctional ApoE receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell. 1995 Jul 28; 82(2):331-40.
    View in: PubMed
    Score: 0.010
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.