Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Bradley Theodore Hyman, M.D., Ph.D.

Co-Author

This page shows the publications co-authored by Bradley Hyman and Brian Bacskai.
Connection Strength

6.949
  1. Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice. Proc Natl Acad Sci U S A. 2003 Oct 14; 100(21):12462-7.
    View in: PubMed
    Score: 0.284
  2. Fluorescence resonance energy transfer determinations using multiphoton fluorescence lifetime imaging microscopy to characterize amyloid-beta plaques. J Biomed Opt. 2003 Jul; 8(3):368-75.
    View in: PubMed
    Score: 0.279
  3. Alzheimer's disease: what multiphoton microscopy teaches us. Neuroscientist. 2002 Oct; 8(5):386-90.
    View in: PubMed
    Score: 0.265
  4. Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy. J Neurosci. 2002 Sep 15; 22(18):7873-8.
    View in: PubMed
    Score: 0.264
  5. Imaging amyloid-beta deposits in vivo. J Cereb Blood Flow Metab. 2002 Sep; 22(9):1035-41.
    View in: PubMed
    Score: 0.264
  6. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med. 2001 Mar; 7(3):369-72.
    View in: PubMed
    Score: 0.238
  7. The endocytic receptor protein LRP also mediates neuronal calcium signaling via N-methyl-D-aspartate receptors. Proc Natl Acad Sci U S A. 2000 Oct 10; 97(21):11551-6.
    View in: PubMed
    Score: 0.231
  8. Soluble oligomeric amyloid-ß induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain. Mol Neurodegener. 2017 03 21; 12(1):27.
    View in: PubMed
    Score: 0.181
  9. Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-ß plaques. Proc Natl Acad Sci U S A. 2015 Dec 22; 112(51):15556-61.
    View in: PubMed
    Score: 0.165
  10. Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):510-4.
    View in: PubMed
    Score: 0.144
  11. Apolipoprotein E, especially apolipoprotein E4, increases the oligomerization of amyloid ß peptide. J Neurosci. 2012 Oct 24; 32(43):15181-92.
    View in: PubMed
    Score: 0.133
  12. Stable size distribution of amyloid plaques over the course of Alzheimer disease. J Neuropathol Exp Neurol. 2012 Aug; 71(8):694-701.
    View in: PubMed
    Score: 0.131
  13. Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-ß revealed by a novel fluorescence resonance energy transfer assay. J Neurosci. 2012 Apr 11; 32(15):5298-309.
    View in: PubMed
    Score: 0.128
  14. Inhibition of the NFAT pathway alleviates amyloid ß neurotoxicity in a mouse model of Alzheimer's disease. J Neurosci. 2012 Feb 29; 32(9):3176-92.
    View in: PubMed
    Score: 0.127
  15. Apolipoprotein E: isoform specific differences in tertiary structure and interaction with amyloid-ß in human Alzheimer brain. PLoS One. 2011 Jan 31; 6(1):e14586.
    View in: PubMed
    Score: 0.118
  16. Monitoring protein aggregation and toxicity in Alzheimer's disease mouse models using in vivo imaging. Methods. 2011 Mar; 53(3):201-7.
    View in: PubMed
    Score: 0.117
  17. Caspase activation precedes and leads to tangles. Nature. 2010 Apr 22; 464(7292):1201-4.
    View in: PubMed
    Score: 0.111
  18. Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation. J Neurosci. 2010 Feb 17; 30(7):2636-49.
    View in: PubMed
    Score: 0.111
  19. A reporter of local dendritic translocation shows plaque- related loss of neural system function in APP-transgenic mice. J Neurosci. 2009 Oct 07; 29(40):12636-40.
    View in: PubMed
    Score: 0.108
  20. Differential effect of three-repeat and four-repeat tau on mitochondrial axonal transport. J Neurochem. 2009 Oct; 111(2):417-27.
    View in: PubMed
    Score: 0.106
  21. Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575. Mol Neurodegener. 2009 May 06; 4:19.
    View in: PubMed
    Score: 0.105
  22. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science. 2009 Feb 27; 323(5918):1211-5.
    View in: PubMed
    Score: 0.103
  23. Antioxidants have a rapid and long-lasting effect on neuritic abnormalities in APP:PS1 mice. Neurobiol Aging. 2010 Dec; 31(12):2058-68.
    View in: PubMed
    Score: 0.102
  24. Passive immunotherapy rapidly increases structural plasticity in a mouse model of Alzheimer disease. Neurobiol Dis. 2009 Feb; 33(2):213-20.
    View in: PubMed
    Score: 0.101
  25. Monitoring tau-tubulin interactions utilizing second harmonic generation in living neurons. J Biomed Opt. 2008 Nov-Dec; 13(6):064039.
    View in: PubMed
    Score: 0.101
  26. Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron. 2008 Jul 31; 59(2):214-25.
    View in: PubMed
    Score: 0.099
  27. Rapid appearance and local toxicity of amyloid-beta plaques in a mouse model of Alzheimer's disease. Nature. 2008 Feb 07; 451(7179):720-4.
    View in: PubMed
    Score: 0.096
  28. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. J Neurosci. 2008 Jan 23; 28(4):862-7.
    View in: PubMed
    Score: 0.096
  29. Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy. J Biomed Opt. 2008 Jan-Feb; 13(1):014008.
    View in: PubMed
    Score: 0.095
  30. Impaired spine stability underlies plaque-related spine loss in an Alzheimer's disease mouse model. Am J Pathol. 2007 Oct; 171(4):1304-11.
    View in: PubMed
    Score: 0.093
  31. A limited role for microglia in antibody mediated plaque clearance in APP mice. Neurobiol Dis. 2007 Dec; 28(3):286-92.
    View in: PubMed
    Score: 0.093
  32. Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model. J Neurochem. 2007 Aug; 102(4):1095-104.
    View in: PubMed
    Score: 0.091
  33. Molecular imaging with Pittsburgh Compound B confirmed at autopsy: a case report. Arch Neurol. 2007 Mar; 64(3):431-4.
    View in: PubMed
    Score: 0.090
  34. Plaque-derived oxidative stress mediates distorted neurite trajectories in the Alzheimer mouse model. J Neuropathol Exp Neurol. 2006 Nov; 65(11):1082-9.
    View in: PubMed
    Score: 0.088
  35. Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays. J Biomed Opt. 2006 Sep-Oct; 11(5):054024.
    View in: PubMed
    Score: 0.087
  36. Physical and functional connection between auxilin and dynamin during endocytosis. EMBO J. 2006 Sep 20; 25(18):4163-74.
    View in: PubMed
    Score: 0.087
  37. Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease. J Neurosci. 2006 Jan 11; 26(2):365-71.
    View in: PubMed
    Score: 0.083
  38. Preclinical characterization of amyloid imaging probes with multiphoton microscopy. J Alzheimers Dis. 2006; 9(3 Suppl):401-7.
    View in: PubMed
    Score: 0.083
  39. Dendritic spine abnormalities in amyloid precursor protein transgenic mice demonstrated by gene transfer and intravital multiphoton microscopy. J Neurosci. 2005 Aug 03; 25(31):7278-87.
    View in: PubMed
    Score: 0.081
  40. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. J Neurosci. 2005 Mar 16; 25(11):3009-17.
    View in: PubMed
    Score: 0.079
  41. The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. J Biol Chem. 2005 May 06; 280(18):17777-85.
    View in: PubMed
    Score: 0.078
  42. Development of an optical approach for noninvasive imaging of Alzheimer's disease pathology. J Biomed Opt. 2005 Jan-Feb; 10(1):11007.
    View in: PubMed
    Score: 0.077
  43. In vivo imaging of amyloid-beta deposits in mouse brain with multiphoton microscopy. Methods Mol Biol. 2005; 299:349-63.
    View in: PubMed
    Score: 0.077
  44. Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. Nat Med. 2004 Oct; 10(10):1065-6.
    View in: PubMed
    Score: 0.076
  45. Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques. J Neurosci. 2004 May 12; 24(19):4535-40.
    View in: PubMed
    Score: 0.074
  46. Amyloid-beta antibody treatment leads to rapid normalization of plaque-induced neuritic alterations. J Neurosci. 2003 Nov 26; 23(34):10879-83.
    View in: PubMed
    Score: 0.072
  47. Monitoring proteins in intact cells. Sci Aging Knowledge Environ. 2003 Jun 11; 2003(23):PE14.
    View in: PubMed
    Score: 0.070
  48. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. J Neurosci. 2003 Jun 01; 23(11):4560-6.
    View in: PubMed
    Score: 0.069
  49. Alzheimer disease's double-edged vaccine. Nat Med. 2003 Apr; 9(4):389-90.
    View in: PubMed
    Score: 0.068
  50. In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy. J Neurosci. 2003 Mar 15; 23(6):2212-7.
    View in: PubMed
    Score: 0.068
  51. In vivo multiphoton imaging of a transgenic mouse model of Alzheimer disease reveals marked thioflavine-S-associated alterations in neurite trajectories. J Neuropathol Exp Neurol. 2003 Feb; 62(2):137-45.
    View in: PubMed
    Score: 0.068
  52. Imaging Abeta plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative. J Neuropathol Exp Neurol. 2002 Sep; 61(9):797-805.
    View in: PubMed
    Score: 0.066
  53. Multiphoton microscopy and amyloid angiopathy. Amyloid. 2001 Jul; 8 Suppl 1:48-50.
    View in: PubMed
    Score: 0.061
  54. Analysis of cerebral amyloid angiopathy in a transgenic mouse model of Alzheimer disease using in vivo multiphoton microscopy. J Neuropathol Exp Neurol. 2001 Mar; 60(3):274-9.
    View in: PubMed
    Score: 0.059
  55. Growth arrest of individual senile plaques in a model of Alzheimer's disease observed by in vivo multiphoton microscopy. J Neurosci. 2001 Feb 01; 21(3):858-64.
    View in: PubMed
    Score: 0.059
  56. Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease. J Neuroimmunol. 2000 Aug 01; 108(1-2):227-35.
    View in: PubMed
    Score: 0.057
  57. Pathogenic PS1 phosphorylation at Ser367. Elife. 2017 01 30; 6.
    View in: PubMed
    Score: 0.045
  58. Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV. Acta Neuropathol Commun. 2014 Sep 09; 2:133.
    View in: PubMed
    Score: 0.038
  59. Regulation of dynamin oligomerization in cells: the role of dynamin-actin interactions and its GTPase activity. Traffic. 2014 Aug; 15(8):819-38.
    View in: PubMed
    Score: 0.037
  60. Tau causes synapse loss without disrupting calcium homeostasis in the rTg4510 model of tauopathy. PLoS One. 2013; 8(11):e80834.
    View in: PubMed
    Score: 0.036
  61. Triflusal reduces dense-core plaque load, associated axonal alterations and inflammatory changes, and rescues cognition in a transgenic mouse model of Alzheimer's disease. Neurobiol Dis. 2010 Jun; 38(3):482-91.
    View in: PubMed
    Score: 0.028
  62. Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. PLoS One. 2009 Nov 18; 4(11):e7893.
    View in: PubMed
    Score: 0.027
  63. Rapid microglial response around amyloid pathology after systemic anti-Abeta antibody administration in PDAPP mice. J Neurosci. 2008 Dec 24; 28(52):14156-64.
    View in: PubMed
    Score: 0.026
  64. The nuclear membrane organization of leukotriene synthesis. Proc Natl Acad Sci U S A. 2008 Dec 23; 105(51):20434-9.
    View in: PubMed
    Score: 0.025
  65. Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy. Brain. 2007 Sep; 130(Pt 9):2310-9.
    View in: PubMed
    Score: 0.023
  66. In vivo optical imaging of amyloid aggregates in brain: design of fluorescent markers. Angew Chem Int Ed Engl. 2005 Aug 26; 44(34):5452-6.
    View in: PubMed
    Score: 0.020
  67. Detection of myelination using a novel histological probe. J Histochem Cytochem. 2005 Dec; 53(12):1511-6.
    View in: PubMed
    Score: 0.020
  68. Progression of cerebral amyloid angiopathy in transgenic mouse models of Alzheimer disease. J Neuropathol Exp Neurol. 2005 Jul; 64(7):588-94.
    View in: PubMed
    Score: 0.020
  69. Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice. J Clin Invest. 2005 Feb; 115(2):428-33.
    View in: PubMed
    Score: 0.019
  70. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron. 2004 Jul 08; 43(1):19-30.
    View in: PubMed
    Score: 0.019
  71. The membrane organization of leukotriene synthesis. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6587-92.
    View in: PubMed
    Score: 0.018
  72. Imaging the pathology of Alzheimer's disease: amyloid-imaging with positron emission tomography. Neuroimaging Clin N Am. 2003 Nov; 13(4):781-9, ix.
    View in: PubMed
    Score: 0.018
  73. Activated Notch1 associates with a presenilin-1/gamma-secretase docking site. J Neurochem. 2003 Nov; 87(4):843-50.
    View in: PubMed
    Score: 0.018
  74. Dysferlin interacts with annexins A1 and A2 and mediates sarcolemmal wound-healing. J Biol Chem. 2003 Dec 12; 278(50):50466-73.
    View in: PubMed
    Score: 0.018
  75. Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J Neurosci. 2002 Aug 01; 22(15):6331-5.
    View in: PubMed
    Score: 0.016
  76. A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain. Bioorg Med Chem Lett. 2002 Feb 11; 12(3):295-8.
    View in: PubMed
    Score: 0.016
Connection Strength
The connection strength for co-authors is the sum of the scores for each of their shared publications.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.