Harvard Catalyst Profiles

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Oksana Berezovska, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. RF1AG044486 (BEREZOVSKA, OKSANA) May 15, 2014 - Mar 31, 2024
    Role of PS1 in neurodegeneration
    Role: Principal Investigator
  2. R01AG044486 (BEREZOVSKA, OKSANA) May 15, 2014 - May 31, 2019
    Role of PS1 in neurodegeneration
    Role: Principal Investigator
  3. R21NS073072 (BEREZOVSKA, OKSANA) Sep 27, 2010 - Aug 31, 2012
    Development of a HTS assay for modulators of presenilin 1 conformation
    Role: Principal Investigator
  4. R01AG026593 (BEREZOVSKA, OKSANA) May 1, 2006 - Dec 1, 2011
    Molecular mechanism of Presenilin-1 (PS1) linked Alzheimer's Disease pathology
    Role: Principal Investigator
  5. P01AG015379 (SELKOE, DENNIS J) Sep 30, 1998 - Apr 30, 2024
    Presenilin Biology and the Mechanisms of Alzheimer's Disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Maesako M, Houser MCQ, Turchyna Y, Wolfe MS, Berezovska O. Presenilin/?-Secretase Activity Is Located in Acidic Compartments of Live Neurons. J Neurosci. 2022 01 05; 42(1):145-154. PMID: 34810230.
    Citations:    Fields:    Translation:AnimalsCells
  2. Houser MCQ, Turchyna Y, Perrin F, Chibnik L, Berezovska O, Maesako M. Limited Substrate Specificity of PS/?-Secretase Is Supported by Novel Multiplexed FRET Analysis in Live Cells. Biosensors (Basel). 2021 May 26; 11(6). PMID: 34073182.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Houser MC, Hou SS, Perrin F, Turchyna Y, Bacskai BJ, Berezovska O, Maesako M. A Novel NIR-FRET Biosensor for Reporting PS/?-Secretase Activity in Live Cells. Sensors (Basel). 2020 Oct 22; 20(21). PMID: 33105735.
    Citations: 2     Fields:    Translation:HumansCells
  4. Maesako M, Sekula NM, Aristarkhova A, Feschenko P, Anderson LC, Berezovska O. Visualization of PS/?-Secretase Activity in Living Cells. iScience. 2020 Jun 26; 23(6):101139. PMID: 32438286.
    Citations: 3     
  5. Maesako M, Zoltowska KM, Berezovska O. Synapsin 1 promotes Aß generation via BACE1 modulation. PLoS One. 2019; 14(12):e0226368. PMID: 31830091.
    Citations: 2     Fields:    Translation:Animals
  6. Keller LJ, Sekula NM, Svirsky S, Maesako M, Zoltowska KM, Berezovska O. Presenilin 1 increases association with synaptotagmin 1 during normal aging. Neurobiol Aging. 2020 02; 86:156-161. PMID: 31864759.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  7. Zoltowska KM, Maesako M, Meier J, Berezovska O. Novel interaction between Alzheimer's disease-related protein presenilin 1 and glutamate transporter 1. Sci Rep. 2018 06 07; 8(1):8718. PMID: 29880815.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  8. Funane T, Hou SS, Zoltowska KM, van Veluw SJ, Berezovska O, Kumar ATN, Bacskai BJ. Selective plane illumination microscopy (SPIM) with time-domain fluorescence lifetime imaging microscopy (FLIM) for volumetric measurement of cleared mouse brain samples. Rev Sci Instrum. 2018 May; 89(5):053705. PMID: 29864842.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  9. Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C. Soluble Gamma-secretase Modulators Attenuate Alzheimer's ß-amyloid Pathology and Induce Conformational Changes in Presenilin 1. EBioMedicine. 2017 Oct; 24:93-101. PMID: 28919280.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  10. Kara E, Marks JD, Fan Z, Klickstein JA, Roe AD, Krogh KA, Wegmann S, Maesako M, Luo CC, Mylvaganam R, Berezovska O, Hudry E, Hyman BT. Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay. J Biol Chem. 2017 09 08; 292(36):14720-14729. PMID: 28684412.
    Citations: 11     Fields:    Translation:HumansCells
  11. Zoltowska KM, Berezovska O. Dynamic Nature of presenilin1/?-Secretase: Implication for Alzheimer's Disease Pathogenesis. Mol Neurobiol. 2018 03; 55(3):2275-2284. PMID: 28332150.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  12. Zoltowska KM, Maesako M, Lushnikova I, Takeda S, Keller LJ, Skibo G, Hyman BT, Berezovska O. Dynamic presenilin 1 and synaptotagmin 1 interaction modulates exocytosis and amyloid ß production. Mol Neurodegener. 2017 02 13; 12(1):15. PMID: 28193235.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  13. Maesako M, Horlacher J, Zoltowska KM, Kastanenka KV, Kara E, Svirsky S, Keller LJ, Li X, Hyman BT, Bacskai BJ, Berezovska O. Pathogenic PS1 phosphorylation at Ser367. Elife. 2017 01 30; 6. PMID: 28132667.
    Citations: 9     Fields:    Translation:AnimalsCells
  14. Zoltowska KM, Maesako M, Berezovska O. Interrelationship between Changes in the Amyloid ß 42/40 Ratio and Presenilin 1 Conformation. Mol Med. 2016 Sep; 22:329-337. PMID: 27391800.
    Citations: 5     Fields:    
  15. Kuzuya A, Zoltowska KM, Post KL, Arimon M, Li X, Svirsky S, Maesako M, Muzikansky A, Gautam V, Kovacs D, Hyman BT, Berezovska O. Identification of the novel activity-driven interaction between synaptotagmin 1 and presenilin 1 links calcium, synapse, and amyloid beta. BMC Biol. 2016 Mar 31; 14:25. PMID: 27036734.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  16. Gautam V, D'Avanzo C, Berezovska O, Tanzi RE, Kovacs DM. Synaptotagmins interact with APP and promote Aß generation. Mol Neurodegener. 2015 Jul 23; 10:31. PMID: 26202512.
    Citations: 18     Fields:    Translation:AnimalsCells
  17. Arimon M, Takeda S, Post KL, Svirsky S, Hyman BT, Berezovska O. Oxidative stress and lipid peroxidation are upstream of amyloid pathology. Neurobiol Dis. 2015 Dec; 84:109-19. PMID: 26102023.
    Citations: 41     Fields:    Translation:AnimalsCells
  18. Elad N, De Strooper B, Lismont S, Hagen W, Veugelen S, Arimon M, Horré K, Berezovska O, Sachse C, Chávez-Gutiérrez L. The dynamic conformational landscape of gamma-secretase. J Cell Sci. 2015 Feb 01; 128(3):589-98. PMID: 25501811.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  19. Winslow AR, Moussaud S, Zhu L, Post KL, Post KL, Dickson DW, Berezovska O, McLean PJ. Convergence of pathology in dementia with Lewy bodies and Alzheimer's disease: a role for the novel interaction of alpha-synuclein and presenilin 1 in disease. Brain. 2014 Jul; 137(Pt 7):1958-70. PMID: 24860142.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  20. Li Y, Lu SH, Tsai CJ, Bohm C, Qamar S, Dodd RB, Meadows W, Jeon A, McLeod A, Chen F, Arimon M, Berezovska O, Hyman BT, Tomita T, Iwatsubo T, Johnson CM, Farrer LA, Schmitt-Ulms G, Fraser PE, St George-Hyslop PH. Structural interactions between inhibitor and substrate docking sites give insight into mechanisms of human PS1 complexes. Structure. 2014 Jan 07; 22(1):125-35. PMID: 24210759.
    Citations: 34     Fields:    Translation:HumansCells
  21. McFarland KN, Huizenga MN, Darnell SB, Sangrey GR, Berezovska O, Cha JH, Outeiro TF, Sadri-Vakili G. MeCP2: a novel Huntingtin interactor. Hum Mol Genet. 2014 Feb 15; 23(4):1036-44. PMID: 24105466.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  22. Wahlster L, Arimon M, Nasser-Ghodsi N, Post KL, Serrano-Pozo A, Uemura K, Berezovska O. Presenilin-1 adopts pathogenic conformation in normal aging and in sporadic Alzheimer's disease. Acta Neuropathol. 2013 Feb; 125(2):187-99. PMID: 23138650.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  23. Li X, Uemura K, Hashimoto T, Nasser-Ghodsi N, Arimon M, Lill CM, Palazzolo I, Krainc D, Hyman BT, Berezovska O. Neuronal activity and secreted amyloid ß lead to altered amyloid ß precursor protein and presenilin 1 interactions. Neurobiol Dis. 2013 Feb; 50:127-34. PMID: 23064434.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  24. Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Modification of ?-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease. EMBO Mol Med. 2012 Jul; 4(7):660-73. PMID: 22488900.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  25. Wu HY, Hudry E, Hashimoto T, Uemura K, Fan ZY, Berezovska O, Grosskreutz CL, Bacskai BJ, Hyman BT. Distinct dendritic spine and nuclear phases of calcineurin activation after exposure to amyloid-ß revealed by a novel fluorescence resonance energy transfer assay. J Neurosci. 2012 Apr 11; 32(15):5298-309. PMID: 22496575.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  26. Ohki Y, Higo T, Uemura K, Shimada N, Osawa S, Berezovska O, Yokoshima S, Fukuyama T, Tomita T, Iwatsubo T. Phenylpiperidine-type ?-secretase modulators target the transmembrane domain 1 of presenilin 1. EMBO J. 2011 Oct 14; 30(23):4815-24. PMID: 22002539.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  27. Asada-Utsugi M, Uemura K, Noda Y, Kuzuya A, Maesako M, Ando K, Kubota M, Watanabe K, Takahashi M, Kihara T, Shimohama S, Takahashi R, Berezovska O, Kinoshita A. N-cadherin enhances APP dimerization at the extracellular domain and modulates Aß production. J Neurochem. 2011 Oct; 119(2):354-63. PMID: 21699541.
    Citations: 18     Fields:    Translation:HumansCells
  28. Fox JH, Connor T, Stiles M, Kama J, Lu Z, Dorsey K, Lieberman G, Liebermann G, Sapp E, Cherny RA, Banks M, Volitakis I, DiFiglia M, Berezovska O, Bush AI, Hersch SM. Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein. J Biol Chem. 2011 May 20; 286(20):18320-30. PMID: 21454633.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  29. Uemura K, Farner KC, Nasser-Ghodsi N, Jones P, Berezovska O. Reciprocal relationship between APP positioning relative to the membrane and PS1 conformation. Mol Neurodegener. 2011 Feb 10; 6(1):15. PMID: 21310068.
    Citations: 11     Fields:    
  30. Viswanathan J, Haapasalo A, Böttcher C, Miettinen R, Kurkinen KM, Lu A, Thomas A, Maynard CJ, Romano D, Hyman BT, Berezovska O, Bertram L, Soininen H, Dantuma NP, Tanzi RE, Hiltunen M. Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation. Traffic. 2011 Mar; 12(3):330-48. PMID: 21143716.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  31. Uemura K, Farner KC, Hashimoto T, Nasser-Ghodsi N, Wolfe MS, Koo EH, Hyman BT, Berezovska O. Substrate docking to ?-secretase allows access of ?-secretase modulators to an allosteric site. Nat Commun. 2010 Nov 30; 1:130. PMID: 21119643.
    Citations: 27     Fields:    
  32. Uemura K, Lill CM, Li X, Peters JA, Ivanov A, Fan Z, DeStrooper B, Bacskai BJ, Hyman BT, Berezovska O. Allosteric modulation of PS1/gamma-secretase conformation correlates with amyloid beta(42/40) ratio. PLoS One. 2009 Nov 18; 4(11):e7893. PMID: 19924286.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  33. Huttunen HJ, Peach C, Bhattacharyya R, Barren C, Pettingell W, Hutter-Paier B, Windisch M, Berezovska O, Kovacs DM. Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway. FASEB J. 2009 Nov; 23(11):3819-28. PMID: 19625658.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  34. Guardia-Laguarta C, Coma M, Pera M, Clarimón J, Sereno L, Agulló JM, Molina-Porcel L, Gallardo E, Deng A, Berezovska O, Hyman BT, Blesa R, Gómez-Isla T, Lleó A. Mild cholesterol depletion reduces amyloid-beta production by impairing APP trafficking to the cell surface. J Neurochem. 2009 Jul; 110(1):220-30. PMID: 19457132.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  35. Serneels L, Van Biervliet J, Craessaerts K, Dejaegere T, Horré K, Van Houtvin T, Esselmann H, Paul S, Schäfer MK, Berezovska O, Hyman BT, Sprangers B, Sciot R, Moons L, Jucker M, Yang Z, May PC, Karran E, Wiltfang J, D'Hooge R, De Strooper B. gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease. Science. 2009 May 01; 324(5927):639-42. PMID: 19299585.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  36. Herl L, Thomas AV, Lill CM, Banks M, Deng A, Jones PB, Spoelgen R, Hyman BT, Berezovska O. Mutations in amyloid precursor protein affect its interactions with presenilin/gamma-secretase. Mol Cell Neurosci. 2009 Jun; 41(2):166-74. PMID: 19281847.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  37. Uemura K, Lill CM, Banks M, Asada M, Aoyagi N, Ando K, Kubota M, Kihara T, Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Berezovska O, Kinoshita A. N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio. J Neurochem. 2009 Jan; 108(2):350-60. PMID: 19046403.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  38. Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ. CHIP targets toxic alpha-Synuclein oligomers for degradation. J Biol Chem. 2008 Jun 27; 283(26):17962-8. PMID: 18436529.
    Citations: 84     Fields:    Translation:HumansCells
  39. Thomas AV, Berezovska O, Hyman BT, von Arnim CA. Visualizing interaction of proteins relevant to Alzheimer's disease in intact cells. Methods. 2008 Apr; 44(4):299-303. PMID: 18374273.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  40. Jones PB, Rozkalne A, Meyer-Luehmann M, Spires-Jones TL, Makarova A, Kumar AT, Berezovska O, Bacskai BB, Hyman BT. Two postprocessing techniques for the elimination of background autofluorescence for fluorescence lifetime imaging microscopy. J Biomed Opt. 2008 Jan-Feb; 13(1):014008. PMID: 18315366.
    Citations: 6     Fields:    Translation:AnimalsCells
  41. Nyborg AC, Herl L, Berezovska O, Thomas AV, Ladd TB, Jansen K, Hyman BT, Golde TE. Signal peptide peptidase (SPP) dimer formation as assessed by fluorescence lifetime imaging microscopy (FLIM) in intact cells. Mol Neurodegener. 2006 Nov 14; 1:16. PMID: 17105660.
    Citations: 11     Fields:    
  42. Jones PB, Herl L, Berezovska O, Kumar AT, Bacskai BJ, Hyman BT. Time-domain fluorescent plate reader for cell based protein-protein interaction and protein conformation assays. J Biomed Opt. 2006 Sep-Oct; 11(5):054024. PMID: 17092173.
    Citations: 6     Fields:    Translation:Cells
  43. Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem. 2006 Oct 27; 281(43):32240-53. PMID: 16945923.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  44. Thomas AV, Herl L, Spoelgen R, Hiltunen M, Jones PB, Tanzi RE, Hyman BT, Berezovska O. Interaction between presenilin 1 and ubiquilin 1 as detected by fluorescence lifetime imaging microscopy and a high-throughput fluorescent plate reader. J Biol Chem. 2006 Sep 08; 281(36):26400-7. PMID: 16815845.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  45. Herl L, Lleo A, Thomas AV, Nyborg AC, Jansen K, Golde TE, Hyman BT, Berezovska O. Detection of presenilin-1 homodimer formation in intact cells using fluorescent lifetime imaging microscopy. Biochem Biophys Res Commun. 2006 Feb 10; 340(2):668-74. PMID: 16376853.
    Citations: 14     Fields:    Translation:AnimalsCells
  46. Tesco G, Ginestroni A, Hiltunen M, Kim M, Dolios G, Hyman BT, Wang R, Berezovska O, Tanzi RE. APP substitutions V715F and L720P alter PS1 conformation and differentially affect Abeta and AICD generation. J Neurochem. 2005 Oct; 95(2):446-56. PMID: 16086682.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  47. Lleó A, Waldron E, von Arnim CA, Herl L, Tangredi MM, Peltan ID, Strickland DK, Koo EH, Hyman BT, Pietrzik CU, Berezovska O. Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretase. J Biol Chem. 2005 Jul 22; 280(29):27303-9. PMID: 15917251.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  48. Berezovska O, Lleo A, Herl LD, Frosch MP, Stern EA, Bacskai BJ, Hyman BT. Familial Alzheimer's disease presenilin 1 mutations cause alterations in the conformation of presenilin and interactions with amyloid precursor protein. J Neurosci. 2005 Mar 16; 25(11):3009-17. PMID: 15772361.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  49. Lleó A, Berezovska O, Herl L, Raju S, Deng A, Bacskai BJ, Frosch MP, Irizarry M, Hyman BT. Nonsteroidal anti-inflammatory drugs lower Abeta42 and change presenilin 1 conformation. Nat Med. 2004 Oct; 10(10):1065-6. PMID: 15448688.
    Citations: 75     Fields:    Translation:AnimalsCells
  50. Irizarry MC, Deng A, Lleo A, Berezovska O, Von Arnim CA, Martin-Rehrmann M, Manelli A, LaDu MJ, Hyman BT, Rebeck GW. Apolipoprotein E modulates gamma-secretase cleavage of the amyloid precursor protein. J Neurochem. 2004 Sep; 90(5):1132-43. PMID: 15312168.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  51. Lleó A, Berezovska O, Growdon JH, Hyman BT. Clinical, pathological, and biochemical spectrum of Alzheimer disease associated with PS-1 mutations. Am J Geriatr Psychiatry. 2004 Mar-Apr; 12(2):146-56. PMID: 15010344.
    Citations: 33     Fields:    Translation:HumansCells
  52. Ramdya P, Skoch J, Bacskai BJ, Hyman BT, Berezovska O. Activated Notch1 associates with a presenilin-1/gamma-secretase docking site. J Neurochem. 2003 Nov; 87(4):843-50. PMID: 14622115.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  53. Das C, Berezovska O, Diehl TS, Genet C, Buldyrev I, Tsai JY, Hyman BT, Wolfe MS. Designed helical peptides inhibit an intramembrane protease. J Am Chem Soc. 2003 Oct 01; 125(39):11794-5. PMID: 14505382.
    Citations: 51     Fields:    Translation:Cells
  54. Lleó A, Berezovska O, Ramdya P, Fukumoto H, Raju S, Shah T, Hyman BT. Notch1 competes with the amyloid precursor protein for gamma-secretase and down-regulates presenilin-1 gene expression. J Biol Chem. 2003 Nov 28; 278(48):47370-5. PMID: 12960155.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  55. Berezovska O, Bacskai BJ, Hyman BT. Monitoring proteins in intact cells. Sci Aging Knowledge Environ. 2003 Jun 11; 2003(23):PE14. PMID: 12844526.
    Citations: 5     Fields:    Translation:HumansCells
  56. Berezovska O, Ramdya P, Skoch J, Wolfe MS, Bacskai BJ, Hyman BT. Amyloid precursor protein associates with a nicastrin-dependent docking site on the presenilin 1-gamma-secretase complex in cells demonstrated by fluorescence lifetime imaging. J Neurosci. 2003 Jun 01; 23(11):4560-6. PMID: 12805296.
    Citations: 35     Fields:    Translation:AnimalsCells
  57. Micchelli CA, Esler WP, Kimberly WT, Jack C, Berezovska O, Kornilova A, Hyman BT, Perrimon N, Wolfe MS. Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila. FASEB J. 2003 Jan; 17(1):79-81. PMID: 12424225.
    Citations: 56     Fields:    Translation:AnimalsCells
  58. Kinoshita A, Whelan CM, Smith CJ, Berezovska O, Hyman BT. Direct visualization of the gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein: association with Fe65 and translocation to the nucleus. J Neurochem. 2002 Aug; 82(4):839-47. PMID: 12358789.
    Citations: 24     Fields:    Translation:HumansCells
  59. Kinoshita A, Whelan CM, Berezovska O, Hyman BT. The gamma secretase-generated carboxyl-terminal domain of the amyloid precursor protein induces apoptosis via Tip60 in H4 cells. J Biol Chem. 2002 Aug 09; 277(32):28530-6. PMID: 12032152.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  60. Zaidi NF, Berezovska O, Choi EK, Miller JS, Chan H, Lilliehook C, Hyman BT, Buxbaum JD, Wasco W. Biochemical and immunocytochemical characterization of calsenilin in mouse brain. Neuroscience. 2002; 114(1):247-63. PMID: 12207970.
    Citations: 10     Fields:    Translation:AnimalsCells
  61. Puglielli L, Konopka G, Pack-Chung E, Ingano LA, Berezovska O, Hyman BT, Chang TY, Tanzi RE, Kovacs DM. Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide. Nat Cell Biol. 2001 Oct; 3(10):905-12. PMID: 11584272.
    Citations: 133     Fields:    Translation:HumansAnimalsCells
  62. Maysinger D, Berezovska O, Savic R, Soo PL, Eisenberg A. Block copolymers modify the internalization of micelle-incorporated probes into neural cells. Biochim Biophys Acta. 2001 Jun 20; 1539(3):205-17. PMID: 11420118.
    Citations: 4     Fields:    Translation:AnimalsCells
  63. Berezovska O, Jack C, Deng A, Gastineau N, Rebeck GW, Hyman BT. Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage. J Biol Chem. 2001 Aug 10; 276(32):30018-23. PMID: 11408475.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  64. Jack C, Berezovska O, Wolfe MS, Hyman BT. Effect of PS1 deficiency and an APP gamma-secretase inhibitor on Notch1 signaling in primary mammalian neurons. Brain Res Mol Brain Res. 2001 Mar 05; 87(2):166-74. PMID: 11245918.
    Citations: 5     Fields:    Translation:AnimalsCells
  65. Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Kimberly WT, Weinmaster G, Selkoe DJ, Hyman BT. Aspartate mutations in presenilin and gamma-secretase inhibitors both impair notch1 proteolysis and nuclear translocation with relative preservation of notch1 signaling. J Neurochem. 2000 Aug; 75(2):583-93. PMID: 10899933.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  66. Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Weinmaster G, Selkoe DJ, Hyman BT. Rapid Notch1 nuclear translocation after ligand binding depends on presenilin-associated gamma-secretase activity. Ann N Y Acad Sci. 2000; 920:223-6. PMID: 11193154.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  67. Wang Y, Berezovska O, Fedoroff S. Expression of colony stimulating factor-1 receptor (CSF-1R) by CNS neurons in mice. J Neurosci Res. 1999 Sep 01; 57(5):616-32. PMID: 10462686.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  68. Berezovska O, Frosch M, McLean P, Knowles R, Koo E, Kang D, Shen J, Lu FM, Lux SE, Tonegawa S, Hyman BT. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons. Brain Res Mol Brain Res. 1999 Jun 08; 69(2):273-80. PMID: 10366748.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  69. Berezovska O, McLean P, Knowles R, Frosh M, Lu FM, Lux SE, Hyman BT. Notch1 inhibits neurite outgrowth in postmitotic primary neurons. Neuroscience. 1999; 93(2):433-9. PMID: 10465425.
    Citations: 69     Fields:    Translation:AnimalsCells
  70. Berezovska O, Xia MQ, Hyman BT. Notch is expressed in adult brain, is coexpressed with presenilin-1, and is altered in Alzheimer disease. J Neuropathol Exp Neurol. 1998 Aug; 57(8):738-45. PMID: 9720489.
    Citations: 44     Fields:    Translation:HumansAnimals
  71. Xia MQ, Berezovska O, Kim TW, Xia WM, Liao A, Tanzi RE, Selkoe D, Hyman BT. Lack of specific association of presenilin 1 (PS-1) protein with plaques and tangles in Alzheimer's disease. J Neurol Sci. 1998 Jun 11; 158(1):15-23. PMID: 9667772.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  72. Rebeck GW, Alonzo NC, Berezovska O, Harr SD, Knowles RB, Growdon JH, Hyman BT, Mendez AJ. Structure and functions of human cerebrospinal fluid lipoproteins from individuals of different APOE genotypes. Exp Neurol. 1998 Jan; 149(1):175-82. PMID: 9454626.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  73. Berezovska O, Xia MQ, Page K, Wasco W, Tanzi RE, Hyman BT. Developmental regulation of presenilin mRNA expression parallels notch expression. J Neuropathol Exp Neurol. 1997 Jan; 56(1):40-4. PMID: 8990127.
    Citations: 9     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.