Harvard Catalyst Profiles

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Herbert Yih-Fuu Lin, M.D., PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R03HD060641 (LIN, HERBERT Y) Jun 24, 2009 - May 31, 2011
    NIH/NICHD
    Role of the BMP co-receptor Dragon (RGMb) in ovarian follicle development
    Role: Principal Investigator
  2. R01DK071837 (LIN, HERBERT Y) Aug 1, 2005 - Jul 31, 2015
    NIH/NIDDK
    Mechanisms of action of hemojuvelin
    Role: Principal Investigator
  3. R01DK069533 (LIN, HERBERT Y) Mar 1, 2005 - Jul 31, 2015
    NIH/NIDDK
    Regulation of BMP signaling in kidney
    Role: Principal Investigator
  4. K08DK002716 (LIN, HERBERT Y) Aug 15, 1999 - Dec 31, 2004
    NIH/NIDDK
    RGS PROTEINS AND PROTEIN TRAFFICKING
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Eddowes LA, Al-Hourani K, Ramamurthy N, Frankish J, Baddock HT, Sandor C, Ryan JD, Fusco DN, Arezes J, Giannoulatou E, Boninsegna S, Chevaliez S, Owens BMJ, Sun CC, Fabris P, Giordani MT, Martines D, Vukicevic S, Crowe J, Lin HY, Rehwinkel J, McHugh PJ, Binder M, Babitt JL, Chung RT, Lawless MW, Armitage AE, Webber C, Klenerman P, Drakesmith H. Antiviral activity of bone morphogenetic proteins and activins. Nat Microbiol. 2019 Feb; 4(2):339-351. PMID: 30510168.
    Citations:    Fields:    
  2. Li Y, Fortin J, Ongaro L, Zhou X, Boehm U, Schneyer A, Bernard DJ, Lin HY. Betaglycan (TGFBR3) Functions as an Inhibin A, but Not Inhibin B, Coreceptor in Pituitary Gonadotrope Cells in Mice. Endocrinology. 2018 Dec 01; 159(12):4077-4091. PMID: 30364975.
    Citations:    Fields:    
  3. Liu W, Chen B, Wang Y, Meng C, Huang H, Huang XR, Qin J, Mulay SR, Anders HJ, Qiu A, Yang B, Freeman GJ, Lu HJ, Lin HY, Zheng ZH, Lan HY, Huang Y, Xia Y. RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism. Proc Natl Acad Sci U S A. 2018 02 13; 115(7):E1475-E1484. PMID: 29382757.
    Citations: 2     Fields:    Translation:Animals
  4. Liu J, Wang W, Liu M, Su L, Zhou H, Xia Y, Ran J, Lin HY, Yang B. Repulsive guidance molecule b inhibits renal cyst development through the bone morphogenetic protein signaling pathway. Cell Signal. 2016 12; 28(12):1842-1851. PMID: 27575743.
    Citations:    Fields:    Translation:AnimalsCells
  5. Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK. On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver. Nat Med. 2016 08; 22(8):945-51. PMID: 27428900; PMCID: PMC4957133.
    Citations: 35     Fields:    Translation:AnimalsCells
  6. Meng C, Liu W, Huang H, Wang Y, Chen B, Freeman GJ, Schneyer A, Lin HY, Xia Y. Repulsive Guidance Molecule b (RGMb) Is Dispensable for Normal Gonadal Function in Mice. Biol Reprod. 2016 Apr; 94(4):78. PMID: 26911425.
    Citations: 1     Fields:    Translation:Animals
  7. Nai A, Rubio A, Campanella A, Gourbeyre O, Artuso I, Bordini J, Gineste A, Latour C, Besson-Fournier C, Lin HY, Coppin H, Roth MP, Camaschella C, Silvestri L, Meynard D. Limiting hepatic Bmp-Smad signaling by matriptase-2 is required for erythropoietin-mediated hepcidin suppression in mice. Blood. 2016 05 12; 127(19):2327-36. PMID: 26755707; PMCID: PMC4865590.
    Citations: 15     Fields:    Translation:AnimalsCells
  8. David V, Martin A, Isakova T, Spaulding C, Qi L, Ramirez V, Zumbrennen-Bullough KB, Sun CC, Lin HY, Babitt JL, Wolf M. Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production. Kidney Int. 2016 Jan; 89(1):135-46. PMID: 26535997; PMCID: PMC4854810.
    Citations: 46     Fields:    Translation:AnimalsCells
  9. Schaefer B, Haschka D, Finkenstedt A, Petersen BS, Theurl I, Henninger B, Janecke AR, Wang CY, Lin HY, Veits L, Vogel W, Weiss G, Franke A, Zoller H. Impaired hepcidin expression in alpha-1-antitrypsin deficiency associated with iron overload and progressive liver disease. Hum Mol Genet. 2015 Nov 01; 24(21):6254-63. PMID: 26310624; PMCID: PMC4599680.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  10. Samir AE, Allegretti AS, Zhu Q, Dhyani M, Anvari A, Sullivan DA, Trottier CA, Dougherty S, Williams WW, Babitt JL, Wenger J, Thadhani RI, Lin HY. Shear wave elastography in chronic kidney disease: a pilot experience in native kidneys. BMC Nephrol. 2015 Jul 31; 16:119. PMID: 26227484; PMCID: PMC4521488.
    Citations: 12     Fields:    Translation:Humans
  11. Tesfay L, Clausen KA, Kim JW, Hegde P, Wang X, Miller LD, Deng Z, Blanchette N, Arvedson T, Miranti CK, Babitt JL, Lin HY, Peehl DM, Torti FM, Torti SV. Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Res. 2015 Jun 01; 75(11):2254-63. PMID: 25858146; PMCID: PMC4454355.
    Citations: 25     Fields:    Translation:HumansCells
  12. Pauk M, Grgurevic L, Brkljacic J, Kufner V, Bordukalo-Niksic T, Grabusic K, Razdorov G, Rogic D, Zuvic M, Oppermann H, Babitt JL, Lin HY, Volarevic S, Vukicevic S. Exogenous BMP7 corrects plasma iron overload and bone loss in Bmp6-/- mice. Int Orthop. 2015 Jan; 39(1):161-72. PMID: 25300398.
    Citations: 4     Fields:    Translation:AnimalsCells
  13. Zhao Y, Xiao X, Frank SJ, Lin HY, Xia Y. Distinct mechanisms of induction of hepatic growth hormone resistance by endogenous IL-6, TNF-a, and IL-1ß. Am J Physiol Endocrinol Metab. 2014 Jul 15; 307(2):E186-98. PMID: 24895283; PMCID: PMC4101637.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  14. Wang CY, Meynard D, Lin HY. The role of TMPRSS6/matriptase-2 in iron regulation and anemia. Front Pharmacol. 2014; 5:114. PMID: 24966834; PMCID: PMC4053654.
    Citations: 8     
  15. Babitt JL, Lin HY. BuMPing iron with modified heparins. Blood. 2014 Mar 06; 123(10):1440-1. PMID: 24627550; PMCID: PMC3945857.
    Citations:    Fields:    Translation:HumansAnimals
  16. Hilgendorf I, Theurl I, Gerhardt LM, Robbins CS, Weber GF, Gonen A, Iwamoto Y, Degousee N, Holderried TA, Winter C, Zirlik A, Lin HY, Sukhova GK, Butany J, Rubin BB, Witztum JL, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Innate response activator B cells aggravate atherosclerosis by stimulating T helper-1 adaptive immunity. Circulation. 2014 Apr 22; 129(16):1677-87. PMID: 24488984; PMCID: PMC3997655.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  17. Meynard D, Sun CC, Wu Q, Chen W, Chen S, Nelson CN, Waters MJ, Babitt JL, Lin HY. Inflammation regulates TMPRSS6 expression via STAT5. PLoS One. 2013; 8(12):e82127. PMID: 24376517; PMCID: PMC3871639.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  18. Meynard D, Babitt JL, Lin HY. The liver: conductor of systemic iron balance. Blood. 2014 Jan 09; 123(2):168-76. PMID: 24200681; PMCID: PMC3888285.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  19. Krause DS, Fulzele K, Catic A, Sun CC, Dombkowski D, Hurley MP, Lezeau S, Attar E, Wu JY, Lin HY, Divieti-Pajevic P, Hasserjian RP, Schipani E, Van Etten RA, Scadden DT. Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med. 2013 Nov; 19(11):1513-7. PMID: 24162813; PMCID: PMC3827980.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  20. Liu W, Li X, Zhao Y, Meng XM, Wan C, Yang B, Lan HY, Lin HY, Xia Y. Dragon (repulsive guidance molecule RGMb) inhibits E-cadherin expression and induces apoptosis in renal tubular epithelial cells. J Biol Chem. 2013 Nov 01; 288(44):31528-39. PMID: 24052264; PMCID: PMC3814749.
    Citations: 5     Fields:    Translation:AnimalsCells
  21. Robbins CS, Hilgendorf I, Weber GF, Theurl I, Iwamoto Y, Figueiredo JL, Gorbatov R, Sukhova GK, Gerhardt LM, Smyth D, Zavitz CC, Shikatani EA, Parsons M, van Rooijen N, Lin HY, Husain M, Libby P, Nahrendorf M, Weissleder R, Swirski FK. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med. 2013 Sep; 19(9):1166-72. PMID: 23933982; PMCID: PMC3769444.
    Citations: 207     Fields:    Translation:AnimalsCells
  22. Sun CC, Vaja V, Chen S, Theurl I, Stepanek A, Brown DE, Cappellini MD, Weiss G, Hong CC, Lin HY, Babitt JL. A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats. Nephrol Dial Transplant. 2013 Jul; 28(7):1733-43. PMID: 23345622; PMCID: PMC3707526.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  23. Bouley R, Nunes P, Andriopoulos B, McLaughlin M, Webber MJ, Lin HY, Babitt JL, Gardella TJ, Ausiello DA, Brown D. Heterologous downregulation of vasopressin type 2 receptor is induced by transferrin. Am J Physiol Renal Physiol. 2013 Mar 01; 304(5):F553-64. PMID: 23235478; PMCID: PMC3602717.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Wu Q, Sun CC, Lin HY, Babitt JL. Repulsive guidance molecule (RGM) family proteins exhibit differential binding kinetics for bone morphogenetic proteins (BMPs). PLoS One. 2012; 7(9):e46307. PMID: 23029472; PMCID: PMC3459908.
    Citations: 18     Fields:    Translation:HumansCells
  25. Gutiérrez OM, Sun CC, Chen W, Babitt JL, Lin HY. Statement of concern about a commercial assay used to measure soluble hemojuvelin in humans. Am J Nephrol. 2012; 36(4):332-3; author reply 333. PMID: 23006450.
    Citations: 6     Fields:    Translation:Humans
  26. Wu X, Yung LM, Cheng WH, Yu PB, Babitt JL, Lin HY, Xia Y. Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent. PLoS One. 2012; 7(9):e44622. PMID: 23028567; PMCID: PMC3441567.
    Citations: 10     Fields:    Translation:AnimalsCells
  27. Babitt JL, Lin HY. Mechanisms of anemia in CKD. J Am Soc Nephrol. 2012 Oct; 23(10):1631-4. PMID: 22935483; PMCID: PMC3458456.
    Citations: 76     Fields:    Translation:Humans
  28. Chen W, Sun CC, Chen S, Meynard D, Babitt JL, Lin HY. A novel validated enzyme-linked immunosorbent assay to quantify soluble hemojuvelin in mouse serum. Haematologica. 2013 Feb; 98(2):296-304. PMID: 22875629; PMCID: PMC3561439.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  29. Lin HY. Transforming growth factor-ß and the kidney revisited: introduction. Semin Nephrol. 2012 May; 32(3):225-7. PMID: 22835452.
    Citations: 1     Fields:    Translation:Humans
  30. Finer G, Schnaper HW, Kanwar YS, Liang X, Lin HY, Hayashida T. Divergent roles of Smad3 and PI3-kinase in murine adriamycin nephropathy indicate distinct mechanisms of proteinuria and fibrogenesis. Kidney Int. 2012 Sep; 82(5):525-36. PMID: 22534961; PMCID: PMC3425729.
    Citations: 10     Fields:    Translation:AnimalsCells
  31. Sun CC, Vaja V, Babitt JL, Lin HY. Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation. Am J Hematol. 2012 Apr; 87(4):392-400. PMID: 22290531; PMCID: PMC3653431.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  32. Ma CH, Brenner GJ, Omura T, Samad OA, Costigan M, Inquimbert P, Niederkofler V, Salie R, Sun CC, Lin HY, Arber S, Coppola G, Woolf CJ, Samad TA. The BMP coreceptor RGMb promotes while the endogenous BMP antagonist noggin reduces neurite outgrowth and peripheral nerve regeneration by modulating BMP signaling. J Neurosci. 2011 Dec 14; 31(50):18391-400. PMID: 22171041; PMCID: PMC3243947.
    Citations: 15     Fields:    Translation:AnimalsCells
  33. Babitt JL, Lin HY. The molecular pathogenesis of hereditary hemochromatosis. Semin Liver Dis. 2011 Aug; 31(3):280-92. PMID: 21901658.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  34. Chen S, Webber MJ, Vilardaga JP, Khatri A, Brown D, Ausiello DA, Lin HY, Bouley R. Visualizing microtubule-dependent vasopressin type 2 receptor trafficking using a new high-affinity fluorescent vasopressin ligand. Endocrinology. 2011 Oct; 152(10):3893-904. PMID: 21828182; PMCID: PMC3176653.
    Citations: 4     Fields:    Translation:AnimalsCells
  35. Corradini E, Rozier M, Meynard D, Odhiambo A, Lin HY, Feng Q, Migas MC, Britton RS, Babitt JL, Fleming RE. Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe. Gastroenterology. 2011 Nov; 141(5):1907-14. PMID: 21745449; PMCID: PMC3634343.
    Citations: 26     Fields:    Translation:AnimalsCells
  36. Theurl I, Schroll A, Sonnweber T, Nairz M, Theurl M, Willenbacher W, Eller K, Wolf D, Seifert M, Sun CC, Babitt JL, Hong CC, Menhall T, Gearing P, Lin HY, Weiss G. Pharmacologic inhibition of hepcidin expression reverses anemia of chronic inflammation in rats. Blood. 2011 Nov 03; 118(18):4977-84. PMID: 21730356; PMCID: PMC3208302.
    Citations: 58     Fields:    Translation:AnimalsCells
  37. Meynard D, Vaja V, Sun CC, Corradini E, Chen S, López-Otín C, Grgurevic L, Hong CC, Stirnberg M, Gütschow M, Vukicevic S, Babitt JL, Lin HY. Regulation of TMPRSS6 by BMP6 and iron in human cells and mice. Blood. 2011 Jul 21; 118(3):747-56. PMID: 21622652; PMCID: PMC3142910.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  38. Wang L, Trebicka E, Fu Y, Ellenbogen S, Hong CC, Babitt JL, Lin HY, Cherayil BJ. The bone morphogenetic protein-hepcidin axis as a therapeutic target in inflammatory bowel disease. Inflamm Bowel Dis. 2012 Jan; 18(1):112-9. PMID: 21351217.
    Citations: 21     Fields:    Translation:AnimalsCells
  39. Gibert Y, Lattanzi VJ, Zhen AW, Vedder L, Brunet F, Faasse SA, Babitt JL, Lin HY, Hammerschmidt M, Fraenkel PG. BMP signaling modulates hepcidin expression in zebrafish embryos independent of hemojuvelin. PLoS One. 2011 Jan 21; 6(1):e14553. PMID: 21283739; PMCID: PMC3024971.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  40. Xia Y, Cortez-Retamozo V, Niederkofler V, Salie R, Chen S, Samad TA, Hong CC, Arber S, Vyas JM, Weissleder R, Pittet MJ, Lin HY. Dragon (repulsive guidance molecule b) inhibits IL-6 expression in macrophages. J Immunol. 2011 Feb 01; 186(3):1369-76. PMID: 21187450; PMCID: PMC3670585.
    Citations: 19     Fields:    Translation:AnimalsCells
  41. Shi S, Hoogaars WM, de Gorter DJ, van Heiningen SH, Lin HY, Hong CC, Kemaladewi DU, Aartsma-Rus A, ten Dijke P, 't Hoen PA. BMP antagonists enhance myogenic differentiation and ameliorate the dystrophic phenotype in a DMD mouse model. Neurobiol Dis. 2011 Feb; 41(2):353-60. PMID: 20940052; PMCID: PMC3674857.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  42. Bolondi G, Garuti C, Corradini E, Zoller H, Vogel W, Finkenstedt A, Babitt JL, Lin HY, Pietrangelo A. Altered hepatic BMP signaling pathway in human HFE hemochromatosis. Blood Cells Mol Dis. 2010 Dec 15; 45(4):308-12. PMID: 20863724; PMCID: PMC3295241.
    Citations: 14     Fields:    Translation:HumansCells
  43. Corradini E, Schmidt PJ, Meynard D, Garuti C, Montosi G, Chen S, Vukicevic S, Pietrangelo A, Lin HY, Babitt JL. BMP6 treatment compensates for the molecular defect and ameliorates hemochromatosis in Hfe knockout mice. Gastroenterology. 2010 Nov; 139(5):1721-9. PMID: 20682319; PMCID: PMC3295242.
    Citations: 33     Fields:    Translation:Animals
  44. Babitt JL, Lin HY. Molecular mechanisms of hepcidin regulation: implications for the anemia of CKD. Am J Kidney Dis. 2010 Apr; 55(4):726-41. PMID: 20189278; PMCID: PMC2905036.
    Citations: 47     Fields:    Translation:Humans
  45. Xia Y, Babitt JL, Bouley R, Zhang Y, Da Silva N, Chen S, Zhuang Z, Samad TA, Brenner GJ, Anderson JL, Hong CC, Schneyer AL, Brown D, Lin HY. Dragon enhances BMP signaling and increases transepithelial resistance in kidney epithelial cells. J Am Soc Nephrol. 2010 Apr; 21(4):666-77. PMID: 20167703; PMCID: PMC2844302.
    Citations: 15     Fields:    Translation:AnimalsCells
  46. Corradini E, Babitt JL, Lin HY. The RGM/DRAGON family of BMP co-receptors. Cytokine Growth Factor Rev. 2009 Oct-Dec; 20(5-6):389-98. PMID: 19897400; PMCID: PMC3715994.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  47. Wang L, Harrington L, Trebicka E, Shi HN, Kagan JC, Hong CC, Lin HY, Babitt JL, Cherayil BJ. Selective modulation of TLR4-activated inflammatory responses by altered iron homeostasis in mice. J Clin Invest. 2009 Nov; 119(11):3322-8. PMID: 19809161.
    Citations: 58     Fields:    Translation:AnimalsCells
  48. Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B, Lin HY, Pietrangelo A, Babitt JL. Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis. Gastroenterology. 2009 Oct; 137(4):1489-97. PMID: 19591830; PMCID: PMC2757523.
    Citations: 49     Fields:    Translation:AnimalsCells
  49. Andriopoulos B, Corradini E, Xia Y, Faasse SA, Chen S, Grgurevic L, Knutson MD, Pietrangelo A, Vukicevic S, Lin HY, Babitt JL. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat Genet. 2009 Apr; 41(4):482-7. PMID: 19252486; PMCID: PMC2810136.
    Citations: 240     Fields:    Translation:HumansAnimals
  50. Zalyapin EA, Bouley R, Hasler U, Vilardaga JP, Lin HY, Brown D, Ausiello DA. Effects of the renal medullary pH and ionic environment on vasopressin binding and signaling. Kidney Int. 2008 Dec; 74(12):1557-67. PMID: 18813286; PMCID: PMC3730289.
    Citations: 8     Fields:    Translation:AnimalsCells
  51. Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood. 2008 May 15; 111(10):5195-204. PMID: 18326817; PMCID: PMC2384142.
    Citations: 86     Fields:    Translation:Humans
  52. Russo LM, Brown D, Lin HY. The soluble transforming growth factor-beta receptor: advantages and applications. Int J Biochem Cell Biol. 2009 Mar; 41(3):472-6. PMID: 18339576.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  53. Yu PB, Hong CC, Sachidanandan C, Babitt JL, Deng DY, Hoyng SA, Lin HY, Bloch KD, Peterson RT. Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nat Chem Biol. 2008 Jan; 4(1):33-41. PMID: 18026094; PMCID: PMC2727650.
    Citations: 358     Fields:    Translation:AnimalsCells
  54. Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest. 2007 Jul; 117(7):1933-9. PMID: 17607365; PMCID: PMC1904317.
    Citations: 166     Fields:    Translation:HumansAnimalsCells
  55. Xia Y, Yu PB, Sidis Y, Beppu H, Bloch KD, Schneyer AL, Lin HY. Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4. J Biol Chem. 2007 Jun 22; 282(25):18129-40. PMID: 17472960.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  56. Yi X, Bouley R, Lin HY, Bechoua S, Sun TX, Del Re E, Shioda T, Raychowdhury MK, Lu HA, Abou-Samra AB, Brown D, Ausiello DA. Alix (AIP1) is a vasopressin receptor (V2R)-interacting protein that increases lysosomal degradation of the V2R. Am J Physiol Renal Physiol. 2007 May; 292(5):F1303-13. PMID: 17287200.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  57. Russo LM, del Re E, Brown D, Lin HY. Evidence for a role of transforming growth factor (TGF)-beta1 in the induction of postglomerular albuminuria in diabetic nephropathy: amelioration by soluble TGF-beta type II receptor. Diabetes. 2007 Feb; 56(2):380-8. PMID: 17259382.
    Citations: 35     Fields:    Translation:AnimalsCells
  58. Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, Andrews NC, Lin HY. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 2006 May; 38(5):531-9. PMID: 16604073.
    Citations: 318     Fields:    Translation:HumansAnimalsCells
  59. Bouley R, Hawthorn G, Russo LM, Lin HY, Ausiello DA, Brown D. Aquaporin 2 (AQP2) and vasopressin type 2 receptor (V2R) endocytosis in kidney epithelial cells: AQP2 is located in 'endocytosis-resistant' membrane domains after vasopressin treatment. Biol Cell. 2006 Apr; 98(4):215-32. PMID: 16563128.
    Citations: 22     Fields:    Translation:AnimalsCells
  60. Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ, Lin HY. Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J Biol Chem. 2005 Aug 19; 280(33):29820-7. PMID: 15975920.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  61. Xia Y, Sidis Y, Mukherjee A, Samad TA, Brenner G, Woolf CJ, Lin HY, Schneyer A. Localization and action of Dragon (repulsive guidance molecule b), a novel bone morphogenetic protein coreceptor, throughout the reproductive axis. Endocrinology. 2005 Aug; 146(8):3614-21. PMID: 15890774; PMCID: PMC1351303.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  62. Bouley R, Lin HY, Raychowdhury MK, Marshansky V, Brown D, Ausiello DA. Downregulation of the vasopressin type 2 receptor after vasopressin-induced internalization: involvement of a lysosomal degradation pathway. Am J Physiol Cell Physiol. 2005 Jun; 288(6):C1390-401. PMID: 15677378.
    Citations: 16     Fields:    Translation:AnimalsCells
  63. Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ. DRAGON, a bone morphogenetic protein co-receptor. J Biol Chem. 2005 Apr 08; 280(14):14122-9. PMID: 15671031.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  64. Schneyer A, Sidis Y, Xia Y, Saito S, del Re E, Lin HY, Keutmann H. Differential actions of follistatin and follistatin-like 3. Mol Cell Endocrinol. 2004 Oct 15; 225(1-2):25-8. PMID: 15451564.
    Citations: 9     Fields:    Translation:Animals
  65. del Re E, Sidis Y, Fabrizio DA, Lin HY, Schneyer A. Reconstitution and analysis of soluble inhibin and activin receptor complexes in a cell-free system. J Biol Chem. 2004 Dec 17; 279(51):53126-35. PMID: 15475360.
    Citations: 13     Fields:    Translation:HumansCells
  66. de Sousa Lopes SM, Roelen BA, Monteiro RM, Emmens R, Lin HY, Li E, Lawson KA, Mummery CL. BMP signaling mediated by ALK2 in the visceral endoderm is necessary for the generation of primordial germ cells in the mouse embryo. Genes Dev. 2004 Aug 01; 18(15):1838-49. PMID: 15289457; PMCID: PMC517404.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  67. del Re E, Babitt JL, Pirani A, Schneyer AL, Lin HY. In the absence of type III receptor, the transforming growth factor (TGF)-beta type II-B receptor requires the type I receptor to bind TGF-beta2. J Biol Chem. 2004 May 21; 279(21):22765-72. PMID: 14996829.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  68. Samad TA, Srinivasan A, Karchewski LA, Jeong SJ, Campagna JA, Ji RR, Fabrizio DA, Zhang Y, Lin HY, Bell E, Woolf CJ. DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. J Neurosci. 2004 Feb 25; 24(8):2027-36. PMID: 14985445.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  69. Bouley R, Sun TX, Chenard M, McLaughlin M, McKee M, Lin HY, Brown D, Ausiello DA. Functional role of the NPxxY motif in internalization of the type 2 vasopressin receptor in LLC-PK1 cells. Am J Physiol Cell Physiol. 2003 Oct; 285(4):C750-62. PMID: 12801889.
    Citations: 21     Fields:    Translation:AnimalsCells
  70. Roelen BA, Cohen OS, Raychowdhury MK, Chadee DN, Zhang Y, Kyriakis JM, Alessandrini AA, Lin HY. Phosphorylation of threonine 276 in Smad4 is involved in transforming growth factor-beta-induced nuclear accumulation. Am J Physiol Cell Physiol. 2003 Oct; 285(4):C823-30. PMID: 12801888.
    Citations: 19     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.