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Joseph B. El-Khoury, M.D.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Reed GM, Keeley JW, Rebello TJ, First MB, Gureje O, Ayuso-Mateos JL, Kanba S, Khoury B, Kogan CS, Krasnov VN, Maj M, de Jesus Mari J, Sharan P, Stein DJ, Zhao M, Akiyama T, Andrews HF, Asevedo E, Cheour M, Domínguez-Martínez T, El-Khoury J, Fiorillo A, Grenier J, Gupta N, Kola L, Kulygina M, Leal-Leturia I, Luciano M, Lusu B, Martínez-López JNI, Matsumoto C, Odunleye M, Onofa LU, Paterniti S, Purnima S, Robles R, Sahu MK, Sibeko G, Zhong N, Gaebel W, Lovell AM, Maruta T, Pike KM, Roberts MC, Medina-Mora ME. Clinical utility of ICD-11 diagnostic guidelines for high-burden mental disorders: results from mental health settings in 13 countries. World Psychiatry. 2018 Oct; 17(3):306-315. PMID: 30192090.
    Citations:    
  2. Reed GM, Sharan P, Rebello TJ, Keeley JW, Elena Medina-Mora M, Gureje O, Luis Ayuso-Mateos J, Kanba S, Khoury B, Kogan CS, Krasnov VN, Maj M, de Jesus Mari J, Stein DJ, Zhao M, Akiyama T, Andrews HF, Asevedo E, Cheour M, Domínguez-Martínez T, El-Khoury J, Fiorillo A, Grenier J, Gupta N, Kola L, Kulygina M, Leal-Leturia I, Luciano M, Lusu B, Nicolas J, Martínez-López I, Matsumoto C, Umukoro Onofa L, Paterniti S, Purnima S, Robles R, Sahu MK, Sibeko G, Zhong N, First MB, Gaebel W, Lovell AM, Maruta T, Roberts MC, Pike KM. The ICD-11 developmental field study of reliability of diagnoses of high-burden mental disorders: results among adult patients in mental health settings of 13 countries. World Psychiatry. 2018 Jun; 17(2):174-186. PMID: 29856568.
    Citations: 1     
  3. Prabhudas M, Bowdish D, Drickamer K, Febbraio M, Herz J, Kobzik L, Krieger M, Loike J, Means TK, Moestrup SK, Post S, Sawamura T, Silverstein S, Wang XY, El Khoury J. Standardizing scavenger receptor nomenclature. J Immunol. 2014 Mar 01; 192(5):1997-2006. PMID: 24563502.
    Citations: 25     Fields:    Translation:HumansAnimals
  4. Hickman SE, El Khoury J. TREM2 and the neuroimmunology of Alzheimer's disease. Biochem Pharmacol. 2014 Apr 15; 88(4):495-8. PMID: 24355566.
    Citations: 39     Fields:    Translation:HumansCells
  5. Hickman SE, Kingery ND, Ohsumi TK, Borowsky ML, Wang LC, Means TK, El Khoury J. The microglial sensome revealed by direct RNA sequencing. Nat Neurosci. 2013 Dec; 16(12):1896-905. PMID: 24162652.
    Citations: 250     Fields:    Translation:AnimalsCells
  6. Ramirez-Ortiz ZG, Pendergraft WF, Prasad A, Byrne MH, Iram T, Blanchette CJ, Luster AD, Hacohen N, El Khoury J, Means TK. The scavenger receptor SCARF1 mediates the clearance of apoptotic cells and prevents autoimmunity. Nat Immunol. 2013 Sep; 14(9):917-26. PMID: 23892722.
    Citations: 56     Fields:    Translation:AnimalsCells
  7. Frenkel D, Wilkinson K, Zhao L, Hickman SE, Means TK, Puckett L, Farfara D, Kingery ND, Weiner HL, El Khoury J. Scara1 deficiency impairs clearance of soluble amyloid-ß by mononuclear phagocytes and accelerates Alzheimer's-like disease progression. Nat Commun. 2013; 4:2030. PMID: 23799536.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  8. Hickman SE, El Khoury J. The neuroimmune system in Alzheimer's disease: the glass is half full. J Alzheimers Dis. 2013; 33 Suppl 1:S295-302. PMID: 22751176.
    Citations: 14     Fields:    Translation:HumansCells
  9. Wilkinson K, El Khoury J. Microglial scavenger receptors and their roles in the pathogenesis of Alzheimer's disease. Int J Alzheimers Dis. 2012; 2012:489456. PMID: 22666621.
    Citations: 39     
  10. El Khoury J. The blood-brain barrier and pathogens: Hadrian's Wall or a Dardanian gate? Virulence. 2012 Mar-Apr; 3(2):157-8. PMID: 22460634.
    Citations:    Fields:    Translation:HumansAnimalsCells
  11. Wilkinson K, Boyd JD, Glicksman M, Moore KJ, El Khoury J. A high content drug screen identifies ursolic acid as an inhibitor of amyloid beta protein interactions with its receptor CD36. J Biol Chem. 2011 Oct 07; 286(40):34914-22. PMID: 21835916.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  12. El Khoury J. Neurodegeneration and the neuroimmune system. Nat Med. 2010 Dec; 16(12):1369-70. PMID: 21135838.
    Citations: 11     Fields:    Translation:HumansCells
  13. Hickman SE, El Khoury J. Mechanisms of mononuclear phagocyte recruitment in Alzheimer's disease. CNS Neurol Disord Drug Targets. 2010 Apr; 9(2):168-73. PMID: 20205643.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  14. Fuchs BB, Eby J, Nobile CJ, El Khoury JB, Mitchell AP, Mylonakis E. Role of filamentation in Galleria mellonella killing by Candida albicans. Microbes Infect. 2010 Jun; 12(6):488-96. PMID: 20223293.
    Citations: 36     Fields:    Translation:Animals
  15. Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A, Rayner KJ, Boyer L, Zhong R, Frazier WA, Lacy-Hulbert A, El Khoury J, Golenbock DT, Moore KJ. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010 Feb; 11(2):155-61. PMID: 20037584.
    Citations: 375     Fields:    Translation:HumansAnimalsCells
  16. Strle K, Drouin EE, Shen S, El Khoury J, McHugh G, Ruzic-Sabljic E, Strle F, Steere AC. Borrelia burgdorferi stimulates macrophages to secrete higher levels of cytokines and chemokines than Borrelia afzelii or Borrelia garinii. J Infect Dis. 2009 Dec 15; 200(12):1936-43. PMID: 19909078.
    Citations: 22     Fields:    Translation:HumansCells
  17. Leung E, Guo L, Bu J, Maloof M, El Khoury J, Geula C. Microglia activation mediates fibrillar amyloid-ß toxicity in the aged primate cortex. Neurobiol Aging. 2011 Mar; 32(3):387-97. PMID: 19349094.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  18. Means TK, Mylonakis E, Tampakakis E, Colvin RA, Seung E, Puckett L, Tai MF, Stewart CR, Pukkila-Worley R, Hickman SE, Moore KJ, Calderwood SB, Hacohen N, Luster AD, El Khoury J. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med. 2009 Mar 16; 206(3):637-53. PMID: 19237602.
    Citations: 81     Fields:    Translation:AnimalsCells
  19. El Khoury J, Luster AD. Mechanisms of microglia accumulation in Alzheimer's disease: therapeutic implications. Trends Pharmacol Sci. 2008 Dec; 29(12):626-32. PMID: 18835047.
    Citations: 72     Fields:    Translation:AnimalsCells
  20. Hickman SE, Allison EK, El Khoury J. Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci. 2008 Aug 13; 28(33):8354-60. PMID: 18701698.
    Citations: 291     Fields:    Translation:AnimalsCells
  21. Campanella GS, Tager AM, El Khoury JK, Thomas SY, Abrazinski TA, Manice LA, Colvin RA, Luster AD. Chemokine receptor CXCR3 and its ligands CXCL9 and CXCL10 are required for the development of murine cerebral malaria. Proc Natl Acad Sci U S A. 2008 Mar 25; 105(12):4814-9. PMID: 18347328.
    Citations: 101     Fields:    Translation:AnimalsCells
  22. Stuart LM, Bell SA, Stewart CR, Silver JM, Richard J, Goss JL, Tseng AA, Zhang A, El Khoury JB, Moore KJ. CD36 signals to the actin cytoskeleton and regulates microglial migration via a p130Cas complex. J Biol Chem. 2007 Sep 14; 282(37):27392-401. PMID: 17623670.
    Citations: 30     Fields:    Translation:AnimalsCells
  23. El Khoury J, Toft M, Hickman SE, Means TK, Terada K, Geula C, Luster AD. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat Med. 2007 Apr; 13(4):432-8. PMID: 17351623.
    Citations: 302     Fields:    Translation:AnimalsCells
  24. Mylonakis E, Moreno R, El Khoury JB, Idnurm A, Heitman J, Calderwood SB, Ausubel FM, Diener A. Galleria mellonella as a model system to study Cryptococcus neoformans pathogenesis. Infect Immun. 2005 Jul; 73(7):3842-50. PMID: 15972469.
    Citations: 154     Fields:    Translation:AnimalsCells
  25. Mylonakis E, Idnurm A, Moreno R, El Khoury J, Rottman JB, Ausubel FM, Heitman J, Calderwood SB. Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. Mol Microbiol. 2004 Oct; 54(2):407-19. PMID: 15469513.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  26. Medeiros LA, Khan T, El Khoury JB, Pham CL, Hatters DM, Howlett GJ, Lopez R, O'Brien KD, Moore KJ. Fibrillar amyloid protein present in atheroma activates CD36 signal transduction. J Biol Chem. 2004 Mar 12; 279(11):10643-8. PMID: 14699114.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  27. El-Khoury J, Fishman JA. Linezolid in the treatment of vancomycin-resistant Enterococcus faecium in solid organ transplant recipients: report of a multicenter compassionate-use trial. Transpl Infect Dis. 2003 Sep; 5(3):121-5. PMID: 14617299.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  28. El Khoury JB, Moore KJ, Means TK, Leung J, Terada K, Toft M, Freeman MW, Luster AD. CD36 mediates the innate host response to beta-amyloid. J Exp Med. 2003 Jun 16; 197(12):1657-66. PMID: 12796468.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  29. Moore KJ, El Khoury J, Medeiros LA, Terada K, Geula C, Luster AD, Freeman MW. A CD36-initiated signaling cascade mediates inflammatory effects of beta-amyloid. J Biol Chem. 2002 Dec 06; 277(49):47373-9. PMID: 12239221.
    Citations: 107     Fields:    Translation:AnimalsCells
  30. Coraci IS, Husemann J, Berman JW, Hulette C, Dufour JH, Campanella GK, Luster AD, Silverstein SC, El-Khoury JB. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. Am J Pathol. 2002 Jan; 160(1):101-12. PMID: 11786404.
    Citations: 115     Fields:    Translation:HumansAnimalsCells
  31. El Khoury J, Stikkelbroeck MM, Goodman A, Rubin RH, Cosimi AB, Fishman JA. Postmenopausal tubo-ovarian abscess due to Pseudomonas aeruginosa in a renal transplant patient: a case report and review of the literature. Transplantation. 2001 Oct 15; 72(7):1241-4. PMID: 11602849.
    Citations:    Fields:    Translation:Humans
  32. Thomas CA, Li Y, Kodama T, Suzuki H, Silverstein SC, El Khoury J. Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis. J Exp Med. 2000 Jan 03; 191(1):147-56. PMID: 10620613.
    Citations: 64     Fields:    Translation:AnimalsCells
  33. Loike JD, Cao L, Budhu S, Marcantonio EE, El Khoury J, Hoffman S, Yednock TA, Silverstein SC. Differential regulation of beta1 integrins by chemoattractants regulates neutrophil migration through fibrin. J Cell Biol. 1999 Mar 08; 144(5):1047-56. PMID: 10085300.
    Citations: 5     Fields:    Translation:HumansCells
  34. Maxeiner H, Husemann J, Thomas CA, Loike JD, El Khoury J, Silverstein SC. Complementary roles for scavenger receptor A and CD36 of human monocyte-derived macrophages in adhesion to surfaces coated with oxidized low-density lipoproteins and in secretion of H2O2. J Exp Med. 1998 Dec 21; 188(12):2257-65. PMID: 9858512.
    Citations: 16     Fields:    Translation:HumansCells
  35. El Khoury J, Hickman SE, Thomas CA, Loike JD, Silverstein SC. Microglia, scavenger receptors, and the pathogenesis of Alzheimer's disease. Neurobiol Aging. 1998 Jan-Feb; 19(1 Suppl):S81-4. PMID: 9562474.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  36. Thomas CA, Weinberger OK, Ziegler BL, Greenberg S, Schieren I, Silverstein SC, El Khoury J. Human immunodeficiency virus-1 env impairs Fc receptor-mediated phagocytosis via a cyclic adenosine monophosphate-dependent mechanism. Blood. 1997 Nov 01; 90(9):3760-5. PMID: 9345063.
    Citations: 3     Fields:    Translation:HumansCells
  37. Benimetskaya L, Loike JD, Khaled Z, Loike G, Silverstein SC, Cao L, el Khoury J, Cai TQ, Stein CA. Mac-1 (CD11b/CD18) is an oligodeoxynucleotide-binding protein. Nat Med. 1997 Apr; 3(4):414-20. PMID: 9095175.
    Citations: 45     Fields:    Translation:HumansCells
  38. El Khoury J, Hickman SE, Thomas CA, Cao L, Silverstein SC, Loike JD. Scavenger receptor-mediated adhesion of microglia to beta-amyloid fibrils. Nature. 1996 Aug 22; 382(6593):716-9. PMID: 8751442.
    Citations: 152     Fields:    Translation:HumansAnimalsCells
  39. Loike JD, el Khoury J, Cao L, Richards CP, Rascoff H, Mandeville JT, Maxfield FR, Silverstein SC. Fibrin regulates neutrophil migration in response to interleukin 8, leukotriene B4, tumor necrosis factor, and formyl-methionyl-leucyl-phenylalanine. J Exp Med. 1995 May 01; 181(5):1763-72. PMID: 7722453.
    Citations: 21     Fields:    Translation:HumansCells
  40. Hickman SE, el Khoury J, Greenberg S, Schieren I, Silverstein SC. P2Z adenosine triphosphate receptor activity in cultured human monocyte-derived macrophages. Blood. 1994 Oct 15; 84(8):2452-6. PMID: 7919365.
    Citations: 30     Fields:    Translation:HumansCells
  41. el Khoury J, Thomas CA, Loike JD, Hickman SE, Cao L, Silverstein SC. Macrophages adhere to glucose-modified basement membrane collagen IV via their scavenger receptors. J Biol Chem. 1994 Apr 08; 269(14):10197-200. PMID: 8144597.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  42. Greenberg S, el Khoury J, Kaplan E, Silverstein SC. A fluorescence technique to distinguish attached from ingested erythrocytes and zymosan particles in phagocytosing macrophages. J Immunol Methods. 1991 May 17; 139(1):115-22. PMID: 2040809.
    Citations: 4     Fields:    Translation:AnimalsCells
  43. Greenberg S, el Khoury J, di Virgilio F, Kaplan EM, Silverstein SC. Ca(2+)-independent F-actin assembly and disassembly during Fc receptor-mediated phagocytosis in mouse macrophages. J Cell Biol. 1991 May; 113(4):757-67. PMID: 2026648.
    Citations: 54     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.