Harvard Catalyst Profiles

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Kathleen Marie Powis, M.D.

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Institution
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Biography
2001 - 2002
Stuart and Lillian Moore Scholarship
2003
Alpha Omega Alpha
2003 - 2003
L. Beverly Chaney Scholarship
2009 - 2010
Botswana Clinical and Research Fellow
2010
Young Investigators Award
2010 - 2011
Botswana Clinical and Research Fellow
2011 - 2012
Scholar Award
2011
Young Investigators Award
2012 - 2017
K23 - Growth Trends and Mortality Risks Among HIV-exposed Infants in Botswana
2015 - 2017
R21 - Evolution of Gut Microbiome among HIV-Exposed Uninfected Infants in Botswana

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI142670 (POWIS, KATHLEEN) Feb 13, 2019 - Jan 31, 2024
    NIH/NIAID
    Immune correlates of tuberculosis and non-tuberculosis infectious morbidity in Southern African HIV-exposed, uninfected infants.
    Role: Principal Investigator
  2. R21HD093531 (POWIS, KATHLEEN) Sep 11, 2018 - Aug 31, 2020
    NIH/NICHD
    INFORM - AIDS FREE: A Harmonized Infrastructure For Monitoring Health Outcomes of the AIDS FREE Generation
    Role: Principal Investigator
  3. R01MH109506 (BUTLER, LISA MICHELLE) Sep 30, 2016 - Jul 31, 2021
    NIH/NIMH
    Multi-Sectoral Agricultural Intervention to Improve Nutrition, Health, and Developmental Outcomes of HIV-infected and Affected Children in Western Kenya
    Role: Co-Investigator
  4. R01DK109881 (JAO, JENNIFER) Apr 1, 2016 - Mar 31, 2021
    NIH
    The Tshilo Dikotla Study: Metabolic Outcomes of Children HIV/ARV-exposed uninfected in Botswana
    Role: Co-Investigator
  5. R21AI120850 (POWIS, KATHLEEN) Aug 1, 2015 - Jul 31, 2017
    NIH/NIAID
    Gut microbiome evolution among HIV-exposed uninfected infants in Botswana
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Slogrove AL, Powis KM. Investment Long Overdue in Primary Studies of HIV-exposed Uninfected Infant Infectious Morbidity. Pediatr Infect Dis J. 2019 Jul; 38(7):e164-e165. PMID: 31192984.
    Citations:    
  2. Slogrove AL, Powis KM, Zash R. Methodological Considerations in Evaluating Pregnancy Outcomes in Women Living With HIV. J Acquir Immune Defic Syndr. 2019 Jun 01; 81(2):e63-e64. PMID: 30839382.
    Citations:    
  3. Slogrove AL, Powis KM, Cotton MF. Human Immunodeficiency Virus-exposed Uninfected Infants: Surviving and Thriving or Overlooked by Success? Clin Infect Dis. 2019 May 30; 68(12):2156-2158. PMID: 30535339.
    Citations:    Fields:    
  4. Powis KM, Slogrove AL, Okorafor I, Millen L, Posada R, Childs J, Abrams EJ, Sperling RS, Jao J. Maternal Perinatal HIV Infection Is Associated With Increased Infectious Morbidity in HIV-exposed Uninfected Infants. Pediatr Infect Dis J. 2019 May; 38(5):500-502. PMID: 30461574.
    Citations:    Fields:    
  5. Cassidy AR, Williams PL, Leidner J, Mayondi G, Ajibola G, Makhema J, Holding PA, Powis KM, Batlang O, Petlo C, Shapiro R, Kammerer B, Lockman S. In Utero Efavirenz Exposure and Neurodevelopmental Outcomes in HIV-exposed Uninfected Children in Botswana. Pediatr Infect Dis J. 2019 Apr 10. PMID: 30985518.
    Citations:    
  6. Powis KM, Siberry GK. Optimising HIV antiretrovirals for mothers and infants. Lancet HIV. 2019 May; 6(5):e272-e273. PMID: 30814029.
    Citations:    
  7. Slogrove AL, Powis KM. Fetal origins of postnatal growth faltering in HIV-exposed uninfected children. Lancet Child Adolesc Health. 2019 Apr; 3(4):201-203. PMID: 30773460.
    Citations:    
  8. Slogrove AL, Powis KM, Bettinger JA, Cotton MF. Considerations in evaluating infectious morbidity and mortality in HIV-exposed uninfected infants. AIDS. 2018 Nov 28; 32(18):2855-2856. PMID: 30407256.
    Citations:    Fields:    
  9. Moyo S, Gaseitsiwe S, Mohammed T, Pretorius Holme M, Wang R, Kotokwe KP, Boleo C, Mupfumi L, Yankinda EK, Chakalisa U, van Widenfelt E, Gaolathe T, Mmalane MO, Dryden-Peterson S, Mine M, Lebelonyane R, Bennett K, Leidner J, Wirth KE, Tchetgen Tchetgen E, Powis K, Moore J, Clarke WA, Lockman S, Makhema JM, Essex M, Novitsky V. Cross-sectional estimates revealed high HIV incidence in Botswana rural communities in the era of successful ART scale-up in 2013-2015. PLoS One. 2018; 13(10):e0204840. PMID: 30356287.
    Citations:    Fields:    
  10. Slogrove AL, Johnson LF, Powis KM. Population-level Mortality Associated with HIV Exposure in HIV-uninfected Infants in Botswana and South Africa: A Model-based Evaluation. J Trop Pediatr. 2018 Oct 12. PMID: 30321432.
    Citations:    Fields:    
  11. Novitsky V, Gaolathe T, Mmalane M, Moyo S, Chakalisa U, Yankinda EK, Marukutira T, Holme MP, Sekoto T, Gaseitsiwe S, Musonda R, van Widenfelt E, Powis KM, Khan N, Dryden-Peterson S, Bennett K, Wirth KE, Tchetgen ET, Bachanas P, Mills LA, Lebelonyane R, El-Halabi S, Makhema J, Lockman S, Essex M. Lack of Virological Suppression Among Young HIV-Positive Adults in Botswana. J Acquir Immune Defic Syndr. 2018 Aug 15; 78(5):557-565. PMID: 29771781.
    Citations:    Fields:    
  12. Moyo S, Gaseitsiwe S, Powis KM, Pretorius Holme M, Mohammed T, Zahralban-Steele M, Yankinde EK, Maphorisa C, Abrams W, Lebelonyane R, Manyake K, Sekoto T, Mmalane M, Gaolathe T, Wirth KE, Makhema J, Lockman S, Clarke W, Essex M, Novitsky V. Undisclosed antiretroviral drug use in Botswana: implication for national estimates. AIDS. 2018 Jul 17; 32(11):1543-1546. PMID: 29762166.
    Citations:    Fields:    
  13. Slogrove AL, Becquet R, Chadwick EG, Côté HCF, Essajee S, Hazra R, Leroy V, Mahy M, Murenga M, Wambui Mwangi J, Oyiengo L, Rollins N, Penazzato M, Seage GR, Serghides L, Vicari M, Powis KM. Surviving and Thriving-Shifting the Public Health Response to HIV-Exposed Uninfected Children: Report of the 3rd HIV-Exposed Uninfected Child Workshop. Front Pediatr. 2018; 6:157. PMID: 29900165.
    Citations:    
  14. Banda FM, Powis KM, Mokoka AB, Mmapetla M, Westmoreland KD, David T, Steenhoff AP. Hearing Impairment Among Children Referred to a Public Audiology Clinic in Gaborone, Botswana. Glob Pediatr Health. 2018; 5:2333794X18770079. PMID: 29761140.
    Citations:    
  15. Powis KM, Lockman S, Ajibola G, Hughes MD, Bennett K, Leidner J, Batlang O, Botebele K, Moyo S, van Widenfelt E, Makhema J, Petlo C, Jibril HB, McIntosh K, Essex M, Shapiro RL. Similar HIV protection from four weeks of zidovudine versus nevirapine prophylaxis among formula-fed infants in Botswana. South Afr J HIV Med. 2018; 19(1):751. PMID: 29707385.
    Citations:    
  16. Novitsky V, Prague M, Moyo S, Gaolathe T, Mmalane M, Yankinda EK, Chakalisa U, Lebelonyane R, Khan N, Powis KM, Widenfelt E, Gaseitsiwe S, Dryden-Peterson SL, Holme MP, De Gruttola V, Bachanas P, Makhema J, Lockman S, Essex M. High HIV-1 RNA Among Newly Diagnosed People in Botswana. AIDS Res Hum Retroviruses. 2018 03; 34(3):300-306. PMID: 29214845.
    Citations:    Fields:    
  17. Jao J, Powis KM, Kirmse B, Yu C, Epie F, Nshom E, Abrams EJ, Sperling RS, Leroith D, Geffner ME, Kurland IJ, Côté HCF. Lower mitochondrial DNA and altered mitochondrial fuel metabolism in HIV-exposed uninfected infants in Cameroon. AIDS. 2017 11 28; 31(18):2475-2481. PMID: 28926411.
    Citations:    Fields:    Translation:HumansCells
  18. Powis KM, Souda S, Lockman S, Ajibola G, Bennett K, Leidner J, Hughes MD, Moyo S, van Widenfelt E, Jibril HB, Makhema J, Essex M, Shapiro RL. Cotrimoxazole prophylaxis was associated with enteric commensal bacterial resistance among HIV-exposed infants in a randomized controlled trial, Botswana. J Int AIDS Soc. 2017 11; 20(3). PMID: 29119726.
    Citations:    Fields:    Translation:HumansCells
  19. Ajibola G, Zash R, Shapiro RL, Batlang O, Botebele K, Bennett K, Chilisa F, Widenfelt EV, Makhema J, Lockman S, Holmes LB, Powis KM. Detecting congenital malformations - Lessons learned from the Mpepu study, Botswana. PLoS One. 2017; 12(3):e0173800. PMID: 28339500.
    Citations:    Fields:    Translation:HumansPHPublic Health
  20. Powis KM, Slogrove AL, Mofenson L. Protecting the health of our AIDS-free generation: beyond prevention of mother-to-child HIV transmission. AIDS. 2017 01 14; 31(2):315-316. PMID: 28002087.
    Citations: 1     Fields:    Translation:Humans
  21. Zash RM, Souda S, Leidner J, Binda K, Hick C, Powis K, Makhema J, Mmalane M, Essex M, Lockman S, Shapiro RL. High Proportion of Deaths Attributable to HIV Among Postpartum Women in Botswana Despite Widespread Uptake of Antiretroviral Therapy. AIDS Patient Care STDS. 2017 Jan; 31(1):14-19. PMID: 28051898.
    Citations: 1     Fields:    Translation:Humans
  22. Moyo S, Mohammed T, Wirth KE, Prague M, Bennett K, Holme MP, Mupfumi L, Sebogodi P, Moraka NO, Boleo C, Maphorisa CN, Seraise B, Gaseitsiwe S, Musonda RM, van Widenfelt E, Powis KM, Gaolathe T, Tchetgen Tchetgen EJ, Makhema JM, Essex M, Lockman S, Novitsky V. Point-of-Care Cepheid Xpert HIV-1 Viral Load Test in Rural African Communities Is Feasible and Reliable. J Clin Microbiol. 2016 12; 54(12):3050-3055. PMID: 27733636.
    Citations: 2     Fields:    Translation:HumansCells
  23. Sudfeld CR, Lei Q, Chinyanga Y, Tumbare E, Khan N, Dapaah-Siakwan F, Sebaka A, Sibiya J, van Widenfelt E, Shapiro RL, Makhema J, Fawzi WW, Powis KM. Linear Growth Faltering Among HIV-Exposed Uninfected Children. J Acquir Immune Defic Syndr. 2016 10 01; 73(2):182-9. PMID: 27116046.
    Citations: 3     Fields:    Translation:Humans
  24. Zash R, Souda S, Leidner J, Ribaudo H, Binda K, Moyo S, Powis KM, Petlo C, Mmalane M, Makhema J, Essex M, Lockman S, Shapiro R. HIV-exposed children account for more than half of 24-month mortality in Botswana. BMC Pediatr. 2016 07 21; 16:103. PMID: 27439303.
    Citations: 5     Fields:    Translation:Humans
  25. Perry ME, Kalenga K, Watkins LF, Mukaya JE, Powis KM, Bennett K, Mmalane M, Makhema J, Shapiro RL. HIV-related mortality at a district hospital in Botswana. Int J STD AIDS. 2017 03; 28(3):277-283. PMID: 27164967.
    Citations:    Fields:    Translation:Humans
  26. Ogwu A, Moyo S, Powis K, Asmelash A, Lockman S, Moffat C, Leidner J, Makhema J, Essex M, Shapiro R. Predictors of early breastfeeding cessation among HIV-infected women in Botswana. Trop Med Int Health. 2016 Aug; 21(8):1013-1018. PMID: 27224454.
    Citations:    Fields:    
  27. Shapiro R, Dryden-Peterson S, Powis K, Zash R, Lockman S. Hidden in plain sight: HIV, antiretrovirals, and stillbirths. Lancet. 2016 May 14; 387(10032):1994-5. PMID: 27203765.
    Citations: 2     Fields:    Translation:Humans
  28. Gaolathe T, Wirth KE, Holme MP, Makhema J, Moyo S, Chakalisa U, Yankinda EK, Lei Q, Mmalane M, Novitsky V, Okui L, van Widenfelt E, Powis KM, Khan N, Bennett K, Bussmann H, Dryden-Peterson S, Lebelonyane R, El-Halabi S, Mills LA, Marukutira T, Wang R, Tchetgen EJ, DeGruttola V, Essex M, Lockman S. Botswana's progress toward achieving the 2020 UNAIDS 90-90-90 antiretroviral therapy and virological suppression goals: a population-based survey. Lancet HIV. 2016 May; 3(5):e221-30. PMID: 27126489.
    Citations: 28     Fields:    
  29. Powis KM, Smeaton L, Hughes MD, Tumbare EA, Souda S, Jao J, Wirth KE, Makhema J, Lockman S, Fawzi W, Essex M, Shapiro RL. In-utero triple antiretroviral exposure associated with decreased growth among HIV-exposed uninfected infants in Botswana. AIDS. 2016 Jan; 30(2):211-20. PMID: 26684818.
    Citations: 6     Fields:    Translation:Humans
  30. Jao J, Kirmse B, Yu C, Qiu Y, Powis K, Nshom E, Epie F, Tih PM, Sperling RS, Abrams EJ, Geffner ME, LeRoith D, Kurland IJ. Lower Preprandial Insulin and Altered Fuel Use in HIV/Antiretroviral-Exposed Infants in Cameroon. J Clin Endocrinol Metab. 2015 Sep; 100(9):3260-9. PMID: 26133363.
    Citations: 6     Fields:    Translation:Humans
  31. Powis K, Lockman S, Smeaton L, Hughes MD, Fawzi W, Ogwu A, Moyo S, van Widenfelt E, von Oettingen J, Makhema J, Essex M, Shapiro RL. Vitamin D insufficiency in HIV-infected pregnant women receiving antiretroviral therapy is not associated with morbidity, mortality or growth impairment in their uninfected infants in Botswana. Pediatr Infect Dis J. 2014 Nov; 33(11):1141-7. PMID: 25037041.
    Citations: 1     Fields:    Translation:HumansCells
  32. Powis KM, Shapiro RL. Protease inhibitors and adverse birth outcomes: is progesterone the missing piece to the puzzle? J Infect Dis. 2015 Jan 01; 211(1):4-7. PMID: 25030057.
    Citations: 5     Fields:    Translation:HumansAnimals
  33. Plank RM, Wirth KE, Ndubuka NO, Abdullahi R, Nkgau M, Lesetedi C, Powis KM, Mmalane M, Makhema J, Shapiro R, Lockman S. Single-arm evaluation of the AccuCirc device for early infant male circumcision in Botswana. J Acquir Immune Defic Syndr. 2014 May 01; 66(1):1-6. PMID: 24594500.
    Citations: 9     Fields:    Translation:HumansCTClinical Trials
  34. Zash RM, Ajose-Popoola O, Stordal K, Souda S, Ogwu A, Dryden-Peterson S, Powis K, Lockman S, Makhema J, Essex M, Shapiro RL. Risk factors for mortality among human immunodeficiency virus-exposed and unexposed infants admitted to a neonatal intensive care unit in Botswana. J Paediatr Child Health. 2014 Mar; 50(3):189-95. PMID: 24372811.
    Citations:    Fields:    Translation:Humans
  35. Dryden-Peterson S, Jayeoba O, Hughes MD, Jibril H, McIntosh K, Modise TA, Asmelash A, Powis KM, Essex M, Shapiro RL, Lockman S. Cotrimoxazole prophylaxis and risk of severe anemia or severe neutropenia in HAART-exposed, HIV-uninfected infants. PLoS One. 2013; 8(9):e74171. PMID: 24086319.
    Citations: 1     Fields:    Translation:Humans
  36. Souda S, Gaseitsiwe S, Georgette N, Powis K, Moremedi D, Iketleng T, Leidner J, Moffat C, Ogwu A, Lockman S, Moyo S, Mmalane M, Musonda R, Makhema J, Essex M, Shapiro R. No clinically significant drug-resistance mutations in HIV-1 subtype C-infected women after discontinuation of NRTI-based or PI-based HAART for PMTCT in Botswana. J Acquir Immune Defic Syndr. 2013 Aug 15; 63(5):572-7. PMID: 23542639.
    Citations: 1     Fields:    Translation:HumansCells
  37. Shapiro RL, Kitch D, Ogwu A, Hughes MD, Lockman S, Powis K, Souda S, Moffat C, Moyo S, McIntosh K, van Widenfelt E, Zwerski S, Mazhani L, Makhema J, Essex M. HIV transmission and 24-month survival in a randomized trial of HAART to prevent MTCT during pregnancy and breastfeeding in Botswana. AIDS. 2013 Jul 31; 27(12):1911-20. PMID: 24180000.
    Citations: 10     Fields:    Translation:Humans
  38. Powis KM, McElrath TF, Hughes MD, Ogwu A, Souda S, Datwyler SA, von Widenfelt E, Moyo S, Nádas M, Makhema J, Machakaire E, Lockman S, Essex M, Shapiro RL. High viral load and elevated angiogenic markers associated with increased risk of preeclampsia among women initiating highly active antiretroviral therapy in pregnancy in the Mma Bana study, Botswana. J Acquir Immune Defic Syndr. 2013 Apr 15; 62(5):517-24. PMID: 23344545.
    Citations: 5     Fields:    Translation:HumansCells
  39. Plank RM, Ndubuka NO, Wirth KE, Mwambona JT, Kebaabetswe P, Bassil B, Lesetedi C, Magetse J, Nkgau M, Makhema J, Mmalane M, Creek T, Powis KM, Shapiro R, Lockman S. A randomized trial of Mogen clamp versus Plastibell for neonatal male circumcision in Botswana. J Acquir Immune Defic Syndr. 2013 Apr 15; 62(5):e131-7. PMID: 23314413.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  40. Plank RM, Kubiak DW, Abdullahi RB, Ndubuka N, Nkgau MM, Dapaah-Siakwan F, Powis KM, Lockman S. Loss of anatomical landmarks with eutectic mixture of local anesthetic cream for neonatal male circumcision. J Pediatr Urol. 2013 Feb; 9(1):e86-90. PMID: 23102766.
    Citations: 2     Fields:    Translation:Humans
  41. Chen JY, Ribaudo HJ, Souda S, Parekh N, Ogwu A, Lockman S, Powis K, Dryden-Peterson S, Creek T, Jimbo W, Madidimalo T, Makhema J, Essex M, Shapiro RL. Highly active antiretroviral therapy and adverse birth outcomes among HIV-infected women in Botswana. J Infect Dis. 2012 Dec 01; 206(11):1695-705. PMID: 23066160.
    Citations: 73     Fields:    Translation:Humans
  42. Shapiro RL, Souda S, Parekh N, Binda K, Kayembe M, Lockman S, Svab P, Babitseng O, Powis K, Jimbo W, Creek T, Makhema J, Essex M, Roberts DJ. High prevalence of hypertension and placental insufficiency, but no in utero HIV transmission, among women on HAART with stillbirths in Botswana. PLoS One. 2012; 7(2):e31580. PMID: 22384039.
    Citations: 6     Fields:    Translation:HumansCells
  43. Shapiro RL, Ribaudo H, Powis K, Chen J, Parekh N. Extended antenatal use of triple antiretroviral therapy for prevention of mother-to-child transmission of HIV-1 correlates with favorable pregnancy outcomes. AIDS. 2012 Jan 02; 26(1):120-1. PMID: 22126816.
    Citations: 2     Fields:    Translation:HumansCells
  44. Powis KM, Kitch D, Ogwu A, Hughes MD, Lockman S, Leidner J, van Widenfelt E, Moffat C, Moyo S, Makhema J, Essex M, Shapiro RL. Increased risk of preterm delivery among HIV-infected women randomized to protease versus nucleoside reverse transcriptase inhibitor-based HAART during pregnancy. J Infect Dis. 2011 Aug 15; 204(4):506-14. PMID: 21791651.
    Citations: 40     Fields:    Translation:Humans
  45. Parekh N, Ribaudo H, Souda S, Chen J, Mmalane M, Powis K, Essex M, Makhema J, Shapiro RL. Risk factors for very preterm delivery and delivery of very-small-for-gestational-age infants among HIV-exposed and HIV-unexposed infants in Botswana. Int J Gynaecol Obstet. 2011 Oct; 115(1):20-5. PMID: 21767835.
    Citations: 8     Fields:    Translation:Humans
  46. Dryden-Peterson S, Shapiro RL, Hughes MD, Powis K, Ogwu A, Moffat C, Moyo S, Makhema J, Essex M, Lockman S. Increased risk of severe infant anemia after exposure to maternal HAART, Botswana. J Acquir Immune Defic Syndr. 2011 Apr 15; 56(5):428-36. PMID: 21266910.
    Citations: 11     Fields:    Translation:HumansCells
  47. Powis KM, Smeaton L, Ogwu A, Lockman S, Dryden-Peterson S, van Widenfelt E, Leidner J, Makhema J, Essex M, Shapiro RL. Effects of in utero antiretroviral exposure on longitudinal growth of HIV-exposed uninfected infants in Botswana. J Acquir Immune Defic Syndr. 2011 Feb 01; 56(2):131-8. PMID: 21124227.
    Citations: 21     Fields:    Translation:Humans
  48. Shapiro RL, Hughes MD, Ogwu A, Kitch D, Lockman S, Moffat C, Makhema J, Moyo S, Thior I, McIntosh K, van Widenfelt E, Leidner J, Powis K, Asmelash A, Tumbare E, Zwerski S, Sharma U, Handelsman E, Mburu K, Jayeoba O, Moko E, Souda S, Lubega E, Akhtar M, Wester C, Tuomola R, Snowden W, Martinez-Tristani M, Mazhani L, Essex M. Antiretroviral regimens in pregnancy and breast-feeding in Botswana. N Engl J Med. 2010 Jun 17; 362(24):2282-94. PMID: 20554983.
    Citations: 154     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.