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Camilia Rivera Martin, M.D.

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Mentoring
Available: 07/11/17, Expires: 07/11/22

The preterm infant is completely dependent on the nutritional practices provided to them while in the neonatal intensive care unit not only for growth, but also to receive the essential immunonutrients and nutritional building blocks to continue organ development and establish their innate immunity. Increasingly, nutrition scientists are establishing the pervasive health consequences of nutritional inputs from genes to metabolic products, including the microbiome. However, how these pathways impact the preterm infant and their ongoing development outside of the womb is largely unknown. This scientific gap has resulted in minimal innovation in specialized nutritional products for the preterm infant. Our lab seeks to understand how our nutritional practices impact health, growth, and development to minimize later sequelae of preterm birth and maximize long term outcomes. Currently our primary focus is in the role of long chain polyunsaturated fatty acids in these processes. Central to these investigations is a clinical biorepository from over 500 infants enrolled with archived longitudinal biological samples; and, several small and large animal models recapitulating neonatal disease processes. Our translational research program in newborn medicine allows for rapid assessment of mechanisms and the testing of potential therapies that can be brought from the bench to bedside. Depending on the background and training of the student, projects can be tailored to meet their interests along the spectrum of translational research.

Early postnatal Lipoxin A4 levels are increased in preterm infants who develop chronic lung disease
Summer, 06/13/11 - 08/15/11

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK104346 (MARTIN, CAMILIA R) Sep 18, 2014 - Aug 31, 2018
    NIH/NIDDK
    Impact of fatty acid imbalance in intestinal health and disease in prematurity
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Singh P, Ochoa-Allemant P, Brown J, Perides G, Freedman SD, Martin CR. Effect of polyunsaturated fatty acids on postnatal ileum development using the fat-1 transgenic mouse model. Pediatr Res. 2019 Mar; 85(4):556-565. PMID: 30653193.
    Citations:    Fields:    
  2. Cabrera Lafuente M, Montes Bueno MT, Pastrana N, Segovia C, Madero Jarabo R, Martin CR, Omeñaca Teres F, Sáenz de Pipaón Marcos M. A prospective analysis of intake and composition of mother's own milk in preterm newborns less than 32 weeks' gestational age. J Perinat Med. 2018 Dec 19; 47(1):106-113. PMID: 29995634.
    Citations:    Fields:    
  3. Obregon E, Martin CR, Frantz Iii ID, Patel P, Smith VC. Neonatal Intensive Care Unit discharge preparedness among families with limited english proficiency. J Perinatol. 2019 Jan; 39(1):135-142. PMID: 30341402.
    Citations:    Fields:    
  4. Shanahan KH, Yu X, Miller LG, Freedman SD, Martin CR. Early Serum Gut Hormone Concentrations Associated With Time to Full Enteral Feedings in Preterm Infants. J Pediatr Gastroenterol Nutr. 2018 Jul; 67(1):97-102. PMID: 29620597.
    Citations:    Fields:    
  5. Lu J, Lu L, Yu Y, Cluette-Brown J, Martin CR, Claud EC. Effects of Intestinal Microbiota on Brain Development in Humanized Gnotobiotic Mice. Sci Rep. 2018 Apr 03; 8(1):5443. PMID: 29615691.
    Citations: 1     Fields:    
  6. Higgins RD, Jobe AH, Koso-Thomas M, Bancalari E, Viscardi RM, Hartert TV, Ryan RM, Kallapur SG, Steinhorn RH, Konduri GG, Davis SD, Thebaud B, Clyman RI, Collaco JM, Martin CR, Woods JC, Finer NN, Raju TNK. Bronchopulmonary Dysplasia: Executive Summary of a Workshop. J Pediatr. 2018 06; 197:300-308. PMID: 29551318.
    Citations: 2     Fields:    
  7. Salas AA, Li P, Parks K, Lal CV, Martin CR, Carlo WA. Early progressive feeding in extremely preterm infants: a randomized trial. Am J Clin Nutr. 2018 Mar 01; 107(3):365-370. PMID: 29529231.
    Citations:    Fields:    
  8. Guthrie G, Tackett B, Stoll B, Martin C, Olutoye O, Burrin DG. Phytosterols Synergize With Endotoxin to Augment Inflammation in Kupffer Cells but Alone Have Limited Direct Effect on Hepatocytes. JPEN J Parenter Enteral Nutr. 2018 Jan; 42(1):37-48. PMID: 28792854.
    Citations:    Fields:    
  9. Robinson JR, Kennedy C, van Arendonk KJ, Green A, Martin CR, Blakely ML. Neurodevelopmental considerations in surgical necrotizing enterocolitis. Semin Pediatr Surg. 2018 Feb; 27(1):52-56. PMID: 29275818.
    Citations:    Fields:    Translation:Humans
  10. Struyvenberg MR, Fong ZV, Martin CR, Tseng JF, Clancy TE, Fernández-Del Castillo C, Tillman HJ, Bellin MD, Freedman SD. Impact of Treatments on Diabetic Control and Gastrointestinal Symptoms After Total Pancreatectomy. Pancreas. 2017 10; 46(9):1188-1195. PMID: 28902790.
    Citations:    Fields:    Translation:Humans
  11. Ravi A, Estensmo ELF, Abée-Lund TML, Foley SL, Allgaier B, Martin CR, Claud EC, Rudi K. Association of the gut microbiota mobilome with hospital location and birth weight in preterm infants. Pediatr Res. 2017 Nov; 82(5):829-838. PMID: 28665922.
    Citations:    Fields:    Translation:HumansCells
  12. Struyvenberg MR, Martin CR, Freedman SD. Practical guide to exocrine pancreatic insufficiency - Breaking the myths. BMC Med. 2017 02 10; 15(1):29. PMID: 28183317.
    Citations: 7     Fields:    Translation:Humans
  13. Cohen J, MacArthur KL, Atsawarungruangkit A, Perillo MC, Martin CR, Berzin TM, Shapiro NI, Sawhney MS, Freedman SD, Sheth SG. Defining the diagnostic value of hyperlipasemia for acute pancreatitis in the critically ill. Pancreatology. 2017 Mar - Apr; 17(2):176-181. PMID: 28237616.
    Citations:    Fields:    Translation:Humans
  14. Martin CR, Stoll B, Cluette-Brown J, Akinkuotu AC, Olutoye OO, Gura KM, Singh P, Zaman MM, Perillo MC, Puder M, Freedman SD, Burrin D. Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA. Nutr Res. 2017 Mar; 39:51-60. PMID: 28385289.
    Citations: 1     Fields:    Translation:Animals
  15. Wilschanski M, Yaakov Y, Omari I, Zaman M, Martin CR, Cohen-Cymberknoh M, Shoseyov D, Kerem E, Dasilva D, Sheth S, Uluer A, O'Sullivan BP, Freedman S. Comparison of Nasal Potential Difference and Intestinal Current Measurements as Surrogate Markers for CFTR Function. J Pediatr Gastroenterol Nutr. 2016 11; 63(5):e92-e97. PMID: 27496797.
    Citations: 1     Fields:    Translation:Humans
  16. Robinson DT, Martin CR. Fatty acid requirements for the preterm infant. Semin Fetal Neonatal Med. 2017 02; 22(1):8-14. PMID: 27599697.
    Citations: 1     Fields:    Translation:Humans
  17. Guthrie G, Kulkarni M, Vlaardingerbroek H, Stoll B, Ng K, Martin C, Belmont J, Hadsell D, Heird W, Newgard CB, Olutoye O, van Goudoever J, Lauridsen C, He X, Schuchman EH, Burrin D. Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions. J Lipid Res. 2016 09; 57(9):1696-711. PMID: 27474222.
    Citations: 1     Fields:    Translation:Animals
  18. Martin CR, Ling PR, Blackburn GL. Review of Infant Feeding: Key Features of Breast Milk and Infant Formula. Nutrients. 2016 May 11; 8(5). PMID: 27187450; PMCID: PMC4882692.
    Citations: 11     Fields:    Translation:Humans
  19. Martin CR, Cheesman A, Brown J, Makda M, Kutner AJ, DaSilva D, Zaman M, Freedman SD. Factors Determining Optimal Fatty Acid Absorption in Preterm Infants. J Pediatr Gastroenterol Nutr. 2016 Jan; 62(1):130-6. PMID: 26252920; PMCID: PMC4691401.
    Citations: 2     Fields:    Translation:Humans
  20. Poindexter BB, Martin CR. Impact of Nutrition on Bronchopulmonary Dysplasia. Clin Perinatol. 2015 Dec; 42(4):797-806. PMID: 26593079.
    Citations: 5     Fields:    Translation:Humans
  21. Tao GZ, Liu B, Zhang R, Liu G, Abdullah F, Harris MC, Brandt ML, Ehrenkranz RA, Bowers C, Martin CR, Moss RL, Sylvester KG. Impaired Activity of Blood Coagulant Factor XIII in Patients with Necrotizing Enterocolitis. Sci Rep. 2015 Aug 17; 5:13119. PMID: 26277871; PMCID: PMC4642514.
    Citations:    Fields:    Translation:HumansCells
  22. Konnikova Y, Zaman MM, Makda M, D'Onofrio D, Freedman SD, Martin CR. Late Enteral Feedings Are Associated with Intestinal Inflammation and Adverse Neonatal Outcomes. PLoS One. 2015; 10(7):e0132924. PMID: 26172126.
    Citations: 1     Fields:    Translation:Humans
  23. Donovan SM, Wang M, Monaco MH, Martin CR, Davidson LA, Ivanov I, Chapkin RS. Noninvasive molecular fingerprinting of host-microbiome interactions in neonates. FEBS Lett. 2014 Nov 17; 588(22):4112-9. PMID: 25042036; PMCID: PMC4253854.
    Citations: 6     Fields:    Translation:HumansAnimals
  24. Soto-Rivera CL, Fichorova RN, Allred EN, Van Marter LJ, Shah B, Martin CR, Agus MS, Leviton A. The relationship between TSH and systemic inflammation in extremely preterm newborns. Endocrine. 2015 Mar; 48(2):595-602. PMID: 24996532; PMCID: PMC4285685.
    Citations: 7     Fields:    Translation:Humans
  25. Knight JM, Davidson LA, Herman D, Martin CR, Goldsby JS, Ivanov IV, Donovan SM, Chapkin RS. Non-invasive analysis of intestinal development in preterm and term infants using RNA-Sequencing. Sci Rep. 2014 Jun 26; 4:5453. PMID: 24965658; PMCID: PMC4071321.
    Citations: 9     Fields:    Translation:Humans
  26. Martin CR, Zaman MM, Gilkey C, Salguero MV, Hasturk H, Kantarci A, Van Dyke TE, Freedman SD. Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury. PLoS One. 2014; 9(6):e98773. PMID: 24892762; PMCID: PMC4043836.
    Citations: 15     Fields:    Translation:Animals
  27. Martin CR. Fatty acid requirements in preterm infants and their role in health and disease. Clin Perinatol. 2014 Jun; 41(2):363-82. PMID: 24873838.
    Citations: 6     Fields:    Translation:Humans
  28. Freedman SD, Martin CR, Aspinall MG. Structuring the patient-physician encounter: Joint creation of an actionable roadmap to health. Healthc (Amst). 2014 Jul; 2(2):94-8. PMID: 26250375.
    Citations:    Fields:    
  29. Bartholomew J, Martin CR, Allred E, Chen ML, Ehrenkranz RA, Dammann O, Leviton A. Risk factors and correlates of neonatal growth velocity in extremely low gestational age newborns: the ELGAN Study. Neonatology. 2013; 104(4):298-304. PMID: 24192897; PMCID: PMC3929951.
    Citations: 2     Fields:    Translation:Humans
  30. Martin CR. Probiotics for the prevention of necrotizing enterocolitis: not just which ones but also why? J Pediatr Gastroenterol Nutr. 2013 Jul; 57(1):3. PMID: 23535765.
    Citations:    
  31. VanderVeen DK, Martin CR, Mehendale R, Allred EN, Dammann O, Leviton A. Early nutrition and weight gain in preterm newborns and the risk of retinopathy of prematurity. PLoS One. 2013; 8(5):e64325. PMID: 23734194; PMCID: PMC3667175.
    Citations: 3     Fields:    Translation:Humans
  32. Martin CR, Bellomy M, Allred EN, Fichorova RN, Leviton A. Systemic inflammation associated with severe intestinal injury in extremely low gestational age newborns. Fetal Pediatr Pathol. 2013 Jun; 32(3):222-34. PMID: 23002960; PMCID: PMC4201234.
    Citations: 14     Fields:    Translation:Humans
  33. Nathe KE, Mancuso CJ, Parad R, Van Marter LJ, Martin CR, Stoler-Barak L, Philbin VJ, Phillips MF, Palmer CD, Levy O. Innate immune activation in neonatal tracheal aspirates suggests endotoxin-driven inflammation. Pediatr Res. 2012 Aug; 72(2):203-11. PMID: 22580716; PMCID: PMC3406551.
    Citations: 2     Fields:    Translation:Humans
  34. Freedman SD, Martin CR. Do patient-accessible electronic medical records help or complicate shared decision making? Virtual Mentor. 2012 Jul 01; 14(7):560-2. PMID: 23351293.
    Citations:    Fields:    Translation:Humans
  35. Martin CR, Zaman MM, Ketwaroo GA, Bhutta AQ, Coronel E, Popov Y, Schuppan D, Freedman SD. CFTR dysfunction predisposes to fibrotic liver disease in a murine model. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 15; 303(4):G474-81. PMID: 22679000; PMCID: PMC3423138.
    Citations: 4     Fields:    Translation:AnimalsCells
  36. Martin CR, Dasilva DA, Cluette-Brown JE, Dimonda C, Hamill A, Bhutta AQ, Coronel E, Wilschanski M, Stephens AJ, Driscoll DF, Bistrian BR, Ware JH, Zaman MM, Freedman SD. Decreased postnatal docosahexaenoic and arachidonic acid blood levels in premature infants are associated with neonatal morbidities. J Pediatr. 2011 Nov; 159(5):743-749.e1-2. PMID: 21658712.
    Citations: 31     Fields:    Translation:Humans
  37. Patel S, Dammann O, Martin CR, Allred EN, Leviton A. Presumed and definite bacteremia in extremely low gestational age newborns. Acta Paediatr. 2011 Jan; 100(1):36-41. PMID: 20712830; PMCID: PMC3006000.
    Citations: 8     Fields:    Translation:Humans
  38. Zaman MM, Martin CR, Andersson C, Bhutta AQ, Cluette-Brown JE, Laposata M, Freedman SD. Linoleic acid supplementation results in increased arachidonic acid and eicosanoid production in CF airway cells and in cftr-/- transgenic mice. Am J Physiol Lung Cell Mol Physiol. 2010 Nov; 299(5):L599-606. PMID: 20656894; PMCID: PMC2980390.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  39. Martin CR, Dammann O, Allred EN, Patel S, O'Shea TM, Kuban KC, Leviton A. Neurodevelopment of extremely preterm infants who had necrotizing enterocolitis with or without late bacteremia. J Pediatr. 2010 Nov; 157(5):751-6.e1. PMID: 20598317; PMCID: PMC2952050.
    Citations: 31     Fields:    Translation:Humans
  40. Belfort MB, Martin CR, Smith VC, Gillman MW, McCormick MC. Infant weight gain and school-age blood pressure and cognition in former preterm infants. Pediatrics. 2010 Jun; 125(6):e1419-26. PMID: 20478940; PMCID: PMC4138041.
    Citations: 13     Fields:    Translation:Humans
  41. Walsh MC, Hibbs AM, Martin CR, Cnaan A, Keller RL, Vittinghoff E, Martin RJ, Truog WE, Ballard PL, Zadell A, Wadlinger SR, Coburn CE, Ballard RA. Two-year neurodevelopmental outcomes of ventilated preterm infants treated with inhaled nitric oxide. J Pediatr. 2010 Apr; 156(4):556-61.e1. PMID: 20138299; PMCID: PMC2843768.
    Citations: 11     Fields:    Translation:Humans
  42. Woods ER, Buka SL, Martin CR, Salganik M, Howard MB, Gueguen JA, Brooks-Gunn J, McCormick MC. Assessing youth risk behavior in a clinical trial setting: lessons from the infant health and development program. J Adolesc Health. 2010 May; 46(5):429-36. PMID: 20413078.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  43. Martin CR, Brown YF, Ehrenkranz RA, O'Shea TM, Allred EN, Belfort MB, McCormick MC, Leviton A. Nutritional practices and growth velocity in the first month of life in extremely premature infants. Pediatrics. 2009 Aug; 124(2):649-57. PMID: 19651583; PMCID: PMC2859427.
    Citations: 22     Fields:    Translation:Humans
  44. Singh H, Dumas GJ, Silvestri AP, Young S, Martin CR, Bistrian BR, Driscoll DF. Physical compatibility of neonatal total parenteral nutrition admixtures containing organic calcium and inorganic phosphate salts in a simulated infusion at 37 degrees C. Pediatr Crit Care Med. 2009 Mar; 10(2):213-6. PMID: 19188866.
    Citations: 3     Fields:    Translation:HumansCells
  45. Martin CR, Walker WA. Probiotics: role in pathophysiology and prevention in necrotizing enterocolitis. Semin Perinatol. 2008 Apr; 32(2):127-37. PMID: 18346537.
    Citations: 26     Fields:    Translation:Humans
  46. Martin CR, Dumas GJ, Shoaie C, Zheng Z, Mackinnon B, Al-Aweel I, Bistrian BR, Pursley DM, Driscoll DF. Incidence of hypertriglyceridemia in critically ill neonates receiving lipid injectable emulsions in glass versus plastic containers: a retrospective analysis. J Pediatr. 2008 Feb; 152(2):232-6. PMID: 18206695.
    Citations: 2     Fields:    Translation:Humans
  47. Gupta M, Mestan KK, Martin CR, Pearson C, Ortiz K, Fu L, Stubblefield P, Cerda S, Kasznica JM, Wang X. Impact of clinical and histologic correlates of maternal and fetal inflammatory response on gestational age in preterm births. J Matern Fetal Neonatal Med. 2007 Jan; 20(1):39-46. PMID: 17437198.
    Citations: 15     Fields:    Translation:Humans
  48. Martin CR, Walker WA. Intestinal immune defences and the inflammatory response in necrotising enterocolitis. Semin Fetal Neonatal Med. 2006 Oct; 11(5):369-77. PMID: 16690363.
    Citations: 31     Fields:    Translation:Humans
  49. McCormick MC, Brooks-Gunn J, Buka SL, Goldman J, Yu J, Salganik M, Scott DT, Bennett FC, Kay LL, Bernbaum JC, Bauer CR, Martin C, Woods ER, Martin A, Casey PH. Early intervention in low birth weight premature infants: results at 18 years of age for the Infant Health and Development Program. Pediatrics. 2006 Mar; 117(3):771-80. PMID: 16510657.
    Citations: 49     Fields:    Translation:Humans
  50. Martin CR, Van Marter LJ, Allred EN, Leviton A. Antenatal glucocorticoids increase early total thyroxine levels in premature infants. Biol Neonate. 2005; 87(4):273-80. PMID: 15703468.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  51. Van Marter LJ, Dammann O, Allred EN, Leviton A, Pagano M, Moore M, Martin C. Chorioamnionitis, mechanical ventilation, and postnatal sepsis as modulators of chronic lung disease in preterm infants. J Pediatr. 2002 Feb; 140(2):171-6. PMID: 11865267.
    Citations: 63     Fields:    Translation:HumansCells
  52. Martin CR, Van Marter LJ, Allred EN, Leviton A. Growth-restricted premature infants are at increased risk for low thyroxine. Early Hum Dev. 2001 Sep; 64(2):119-28. PMID: 11440824.
    Citations:    Fields:    Translation:HumansPHPublic Health
  53. Collins JW, Martin CR. Relation of traditional risk factors to intrauterine growth retardation among United States-born and foreign-born Mexican Americans in Chicago. Ethn Dis. 1998; 8(1):21-5. PMID: 9595244.
    Citations: 4     Fields:    Translation:Humans
  54. Bowen W, Martin CR, Krauss AN, Auld PA. Ventilation-perfusion relationships in preterm infants after surfactant treatment. Pediatr Pulmonol. 1994 Sep; 18(3):155-62. PMID: 7800432.
    Citations:    Fields:    Translation:HumansCTClinical Trials
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.