Harvard Catalyst Profiles

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Michiko K. Oyoshi, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI151591 (OYOSHI, MICHIKO) Apr 15, 2021 - Mar 31, 2023
    Role of maternal Treg cells in the induction of neonatal tolerance
    Role: Principal Investigator
  2. R01AI142872 (OYOSHI, MICHIKO) Dec 1, 2018 - Nov 30, 2021
    Induction of food allergen-specific neonatal tolerance through breast milk
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tanzer J, Meng D, Ohsaki A, Caldwell JM, Mingler MK, Rothenberg ME, Oyoshi MK. Laundry detergent promotes allergic skin inflammation and esophageal eosinophilia in mice. PLoS One. 2022; 17(6):e0268651. PMID: 35759448; PMCID: PMC9236249.
    Citations:    Fields:    Translation:Animals
  2. Oyoshi M, Chinthrajah RS. Editorial: Insights Into the Etiology, Prevention, and Treatment of Food Allergy. Front Immunol. 2020; 11:1937. PMID: 32973797.
    Citations:    Fields:    Translation:HumansAnimals
  3. Kanagaratham C, El Ansari YS, Sallis BF, Hollister BA, Lewis OL, Minnicozzi SC, Oyoshi MK, Rosen R, Nurko S, Fiebiger E, Oettgen HC. Omeprazole inhibits IgE-mediated mast cell activation and allergic inflammation induced by ingested allergen in mice. J Allergy Clin Immunol. 2020 10; 146(4):884-893.e5. PMID: 32194041; PMCID: PMC7492424.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  4. Fujimura T, Lum SZC, Nagata Y, Kawamoto S, Oyoshi MK. Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy. Front Immunol. 2019; 10:1933. PMID: 31507589.
    Citations: 10     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  5. Järvinen KM, Martin H, Oyoshi MK. Immunomodulatory effects of breast milk on food allergy. Ann Allergy Asthma Immunol. 2019 08; 123(2):133-143. PMID: 31048004; PMCID: PMC6693634.
    Citations: 24     Fields:    Translation:HumansAnimals
  6. Archer NK, Jo JH, Lee SK, Kim D, Smith B, Ortines RV, Wang Y, Marchitto MC, Ravipati A, Cai SS, Dillen CA, Liu H, Miller RJ, Ashbaugh AG, Uppal AS, Oyoshi MK, Malhotra N, Hoff S, Garza LA, Kong HH, Segre JA, Geha RS, Miller LS. Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1a release. J Allergy Clin Immunol. 2019 04; 143(4):1426-1443.e6. PMID: 30240702; PMCID: PMC6424655.
    Citations: 21     Fields:    Translation:AnimalsCells
  7. Hoff S, Oyoshi MK, Hornick JL, Geha RS. MyD88 signaling in T regulatory cells by endogenous ligands dampens skin inflammation in filaggrin deficient mice. Clin Immunol. 2018 10; 195:88-92. PMID: 30099194.
    Citations:    Fields:    Translation:HumansAnimalsCells
  8. Ohsaki A, Venturelli N, Buccigrosso TM, Osganian SK, Lee J, Blumberg RS, Oyoshi MK. Maternal IgG immune complexes induce food allergen-specific tolerance in offspring. J Exp Med. 2018 01 02; 215(1):91-113. PMID: 29158374; PMCID: PMC5748859.
    Citations: 48     Fields:    Translation:AnimalsCellsPHPublic Health
  9. Yoon J, Leyva-Castillo JM, Wang G, Galand C, Oyoshi MK, Kumar L, Hoff S, He R, Chervonsky A, Oppenheim JJ, Kuchroo VK, van den Brink MR, Malefyt Rde W, Tessier PA, Fuhlbrigge R, Rosenstiel P, Terhorst C, Murphy G, Geha RS. IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization. J Exp Med. 2016 09 19; 213(10):2147-66. PMID: 27551155; PMCID: PMC5032726.
    Citations: 28     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  10. Galand C, Leyva-Castillo JM, Yoon J, Han A, Lee MS, McKenzie ANJ, Stassen M, Oyoshi MK, Finkelman FD, Geha RS. IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells. J Allergy Clin Immunol. 2016 11; 138(5):1356-1366. PMID: 27372570; PMCID: PMC5099088.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  11. Venturelli N, Lexmond WS, Ohsaki A, Nurko S, Karasuyama H, Fiebiger E, Oyoshi MK. Allergic skin sensitization promotes eosinophilic esophagitis through the IL-33-basophil axis in mice. J Allergy Clin Immunol. 2016 11; 138(5):1367-1380.e5. PMID: 27233150.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  12. Oyoshi MK, Venturelli N, Geha RS. Thymic stromal lymphopoietin and IL-33 promote skin inflammation and vaccinia virus replication in a mouse model of atopic dermatitis. J Allergy Clin Immunol. 2016 07; 138(1):283-286. PMID: 26830114; PMCID: PMC4931957.
    Citations: 13     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  13. Oyoshi MK. Recent research advances in eosinophilic esophagitis. Curr Opin Pediatr. 2015 Dec; 27(6):741-7. PMID: 26418324.
    Citations: 3     Fields:    Translation:Humans
  14. Oyoshi MK, Beaupré J, Venturelli N, Lewis CN, Iwakura Y, Geha RS. Filaggrin deficiency promotes the dissemination of cutaneously inoculated vaccinia virus. J Allergy Clin Immunol. 2015 Jun; 135(6):1511-8.e6. PMID: 25649082; PMCID: PMC4461532.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  15. Hoff S, Oyoshi MK, Macpherson A, Geha RS. The microbiota is important for IL-17A expression and neutrophil infiltration in lesional skin of Flg(ft/ft) mice. Clin Immunol. 2015 Feb; 156(2):128-30. PMID: 25499749; PMCID: PMC5800788.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Massaad MJ, Oyoshi MK, Kane J, Koduru S, Alcaide P, Nakamura F, Ramesh N, Luscinskas FW, Hartwig J, Geha RS. Binding of WIP to actin is essential for T cell actin cytoskeleton integrity and tissue homing. Mol Cell Biol. 2014 Dec 01; 34(23):4343-54. PMID: 25246631.
    Citations: 10     Fields:    Translation:AnimalsCells
  17. Oyoshi MK, Oettgen HC, Chatila TA, Geha RS, Bryce PJ. Food allergy: Insights into etiology, prevention, and treatment provided by murine models. J Allergy Clin Immunol. 2014 Feb; 133(2):309-17. PMID: 24636470; PMCID: PMC3959655.
    Citations: 38     Fields:    Translation:HumansAnimals
  18. Darling AR, Freyschmidt EJ, Burton OT, Koleoglou KJ, Oyoshi MK, Oettgen HC. IL-10 suppresses IL-17-mediated dermal inflammation and reduces the systemic burden of Vaccinia virus in a mouse model of eczema vaccinatum. Clin Immunol. 2014 Feb; 150(2):153-60. PMID: 24412909.
    Citations: 11     Fields:    Translation:AnimalsCells
  19. Leisten S, Oyoshi MK, Galand C, Hornick JL, Gurish MF, Geha RS. Development of skin lesions in filaggrin-deficient mice is dependent on adaptive immunity. J Allergy Clin Immunol. 2013 Apr; 131(4):1247-50, 1250.e1. PMID: 23540619.
    Citations: 6     Fields:    Translation:AnimalsCells
  20. Bartnikas LM, Gurish MF, Burton OT, Leisten S, Janssen E, Oettgen HC, Beaupré J, Lewis CN, Austen KF, Schulte S, Hornick JL, Geha RS, Oyoshi MK. Epicutaneous sensitization results in IgE-dependent intestinal mast cell expansion and food-induced anaphylaxis. J Allergy Clin Immunol. 2013 Feb; 131(2):451-60.e1-6. PMID: 23374269; PMCID: PMC3587010.
    Citations: 50     Fields:    Translation:AnimalsCells
  21. Brauweiler AM, Bin L, Kim BE, Oyoshi MK, Geha RS, Goleva E, Leung DY. Filaggrin-dependent secretion of sphingomyelinase protects against staphylococcal a-toxin-induced keratinocyte death. J Allergy Clin Immunol. 2013 Feb; 131(2):421-7.e1-2. PMID: 23246020; PMCID: PMC3742335.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  22. Oyoshi MK, He R, Li Y, Mondal S, Yoon J, Afshar R, Chen M, Lee DM, Luo HR, Luster AD, Cho JS, Miller LS, Larson A, Murphy GF, Geha RS. Leukotriene B4-driven neutrophil recruitment to the skin is essential for allergic skin inflammation. Immunity. 2012 Oct 19; 37(4):747-58. PMID: 23063331.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  23. Garber JJ, Takeshima F, Antón IM, Oyoshi MK, Lyubimova A, Kapoor A, Shibata T, Chen F, Alt FW, Geha RS, Leong JM, Snapper SB. Enteropathogenic Escherichia coli and vaccinia virus do not require the family of WASP-interacting proteins for pathogen-induced actin assembly. Infect Immun. 2012 Dec; 80(12):4071-7. PMID: 22966049.
    Citations: 4     Fields:    Translation:AnimalsCells
  24. Oyoshi MK, He R, Kanaoka Y, ElKhal A, Kawamoto S, Lewis CN, Austen KF, Geha RS. Eosinophil-derived leukotriene C4 signals via type 2 cysteinyl leukotriene receptor to promote skin fibrosis in a mouse model of atopic dermatitis. Proc Natl Acad Sci U S A. 2012 Mar 27; 109(13):4992-7. PMID: 22416124.
    Citations: 23     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  25. Oyoshi MK, Ramesh N, Geha RS. Vaccinia Ig ameliorates eczema vaccinatum in a murine model of atopic dermatitis. J Invest Dermatol. 2012 Apr; 132(4):1299-301. PMID: 22189790.
    Citations: 1     Fields:    Translation:AnimalsCells
  26. Oyoshi MK, Wang JY, Geha RS. Immunization with modified vaccinia virus Ankara prevents eczema vaccinatum in a murine model of atopic dermatitis. J Allergy Clin Immunol. 2011 Oct; 128(4):890-892.e3. PMID: 21820712; PMCID: PMC3185136.
    Citations: 4     Fields:    Translation:AnimalsCells
  27. Oyoshi MK, Elkhal A, Scott JE, Wurbel MA, Hornick JL, Campbell JJ, Geha RS. Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin. J Clin Invest. 2011 Jun; 121(6):2210-20. PMID: 21537081; PMCID: PMC3105371.
    Citations: 26     Fields:    Translation:AnimalsCellsPHPublic Health
  28. Oyoshi MK, Larson RP, Ziegler SF, Geha RS. Mechanical injury polarizes skin dendritic cells to elicit a T(H)2 response by inducing cutaneous thymic stromal lymphopoietin expression. J Allergy Clin Immunol. 2010 Nov; 126(5):976-84, 984.e1-5. PMID: 21050944; PMCID: PMC3085022.
    Citations: 96     Fields:    Translation:AnimalsCells
  29. Koduru S, Kumar L, Massaad MJ, Ramesh N, Le Bras S, Ozcan E, Oyoshi MK, Kaku M, Fujiwara Y, Kremer L, King S, Fuhlbrigge R, Rodig S, Sage P, Carman C, Alcaide P, Luscinskas FW, Geha RS. Cdc42 interacting protein 4 (CIP4) is essential for integrin-dependent T-cell trafficking. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16252-6. PMID: 20805498.
    Citations: 19     Fields:    Translation:AnimalsCells
  30. He R, Oyoshi MK, Wang JY, Hodge MR, Jin H, Geha RS. The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge. J Allergy Clin Immunol. 2010 Oct; 126(4):784-90. PMID: 20713302; PMCID: PMC2950231.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  31. He R, Kim HY, Yoon J, Oyoshi MK, MacGinnitie A, Goya S, Freyschmidt EJ, Bryce P, McKenzie AN, Umetsu DT, Oettgen HC, Geha RS. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. J Allergy Clin Immunol. 2009 Oct; 124(4):761-70.e1. PMID: 19815118; PMCID: PMC2895457.
    Citations: 45     Fields:    Translation:AnimalsCells
  32. Oyoshi MK, Elkhal A, Kumar L, Scott JE, Koduru S, He R, Leung DY, Howell MD, Oettgen HC, Murphy GF, Geha RS. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14954-9. PMID: 19706451.
    Citations: 27     Fields:    Translation:AnimalsCells
  33. Oyoshi MK, Murphy GF, Geha RS. Filaggrin-deficient mice exhibit TH17-dominated skin inflammation and permissiveness to epicutaneous sensitization with protein antigen. J Allergy Clin Immunol. 2009 Sep; 124(3):485-93, 493.e1. PMID: 19665780; PMCID: PMC2886150.
    Citations: 71     Fields:    Translation:AnimalsCells
  34. Le Bras S, Massaad M, Koduru S, Kumar L, Oyoshi MK, Hartwig J, Geha RS. WIP is critical for T cell responsiveness to IL-2. Proc Natl Acad Sci U S A. 2009 May 05; 106(18):7519-24. PMID: 19359486.
    Citations: 11     Fields:    Translation:AnimalsCells
  35. Oyoshi MK, He R, Kumar L, Yoon J, Geha RS. Cellular and molecular mechanisms in atopic dermatitis. Adv Immunol. 2009; 102:135-226. PMID: 19477321.
    Citations: 66     Fields:    Translation:HumansAnimals
  36. Jin H, He R, Oyoshi M, Geha RS. Animal models of atopic dermatitis. J Invest Dermatol. 2009 Jan; 129(1):31-40. PMID: 19078986.
    Citations: 148     Fields:    Translation:HumansAnimals
  37. Jin H, Oyoshi MK, Le Y, Bianchi T, Koduru S, Mathias CB, Kumar L, Le Bras S, Young D, Collins M, Grusby MJ, Wenzel J, Bieber T, Boes M, Silberstein LE, Oettgen HC, Geha RS. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest. 2009 Jan; 119(1):47-60. PMID: 19075398; PMCID: PMC2613448.
    Citations: 39     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  38. He R, Oyoshi MK, Garibyan L, Kumar L, Ziegler SF, Geha RS. TSLP acts on infiltrating effector T cells to drive allergic skin inflammation. Proc Natl Acad Sci U S A. 2008 Aug 19; 105(33):11875-80. PMID: 18711124.
    Citations: 104     Fields:    Translation:AnimalsCells
  39. Oyoshi MK, Bryce P, Goya S, Pichavant M, Umetsu DT, Oettgen HC, Tsitsikov EN. TNF receptor-associated factor 1 expressed in resident lung cells is required for the development of allergic lung inflammation. J Immunol. 2008 Feb 01; 180(3):1878-85. PMID: 18209085.
    Citations: 9     Fields:    Translation:AnimalsCells
  40. He R, Oyoshi MK, Jin H, Geha RS. Epicutaneous antigen exposure induces a Th17 response that drives airway inflammation after inhalation challenge. Proc Natl Acad Sci U S A. 2007 Oct 02; 104(40):15817-22. PMID: 17893340; PMCID: PMC2000444.
    Citations: 70     Fields:    Translation:AnimalsCellsPHPublic Health
  41. Oyoshi MK, Barthel R, Tsitsikov EN. TRAF1 regulates recruitment of lymphocytes and, to a lesser extent, neutrophils, myeloid dendritic cells and monocytes to the lung airways following lipopolysaccharide inhalation. Immunology. 2007 Mar; 120(3):303-14. PMID: 17328785.
    Citations: 7     Fields:    Translation:AnimalsCells
  42. Bryce PJ, Oyoshi MK, Kawamoto S, Oettgen HC, Tsitsikov EN. TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45. Int Immunol. 2006 Jan; 18(1):101-11. PMID: 16352630.
    Citations: 15     Fields:    Translation:AnimalsCells
  43. Zhang Y, Nagata H, Ikeuchi T, Mukai H, Oyoshi MK, Demachi A, Morio T, Wakiguchi H, Kimura N, Shimizu N, Yamamoto K. Common cytological and cytogenetic features of Epstein-Barr virus (EBV)-positive natural killer (NK) cells and cell lines derived from patients with nasal T/NK-cell lymphomas, chronic active EBV infection and hydroa vacciniforme-like eruptions. Br J Haematol. 2003 Jun; 121(5):805-14. PMID: 12780797.
    Citations: 37     Fields:    Translation:HumansCells
  44. Oyoshi MK, Nagata H, Kimura N, Zhang Y, Demachi A, Hara T, Kanegane H, Matsuo Y, Yamaguchi T, Morio T, Hirano A, Shimizu N, Yamamoto K. Preferential expansion of Vgamma9-JgammaP/Vdelta2-Jdelta3 gammadelta T cells in nasal T-cell lymphoma and chronic active Epstein-Barr virus infection. Am J Pathol. 2003 May; 162(5):1629-38. PMID: 12707047; PMCID: PMC1851204.
    Citations: 8     Fields:    Translation:HumansCells
  45. Demachi A, Nagata H, Morio T, Oyoshi MK, Zhang Y, Tabata N, Kimura N, Shimizu N, Yamamoto K. Characterization of Epstein-Barr virus (EBV)-positive NK cells isolated from hydroa vacciniforme-like eruptions. Microbiol Immunol. 2003; 47(7):543-52. PMID: 12953848.
    Citations: 2     Fields:    Translation:Cells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.