Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Scott L. Schissel, M.D., D.Phil.

Title
Institution
Department
Address
Phone
Fax

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Most Recent  |  List All
  1. K08HL088492 (SCHISSEL, SCOTT LEWIS) Apr 1, 2007 - Mar 31, 2012
    NIH
    Role of Aortic Carboxypeptidase-like Protein in Pulmonary Fibrosis
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Baron RM, Kwon MY, Castano AP, Ghanta S, Riascos-Bernal DF, Lopez-Guzman S, Macias AA, Ith B, Schissel SL, Lederer JA, Reeves R, Yet SF, Layne MD, Liu X, Perrella MA. Frontline Science: Targeted expression of a dominant-negative high mobility group A1 transgene improves outcome in sepsis. J Leukoc Biol. 2018 10; 104(4):677-689. PMID: 29975792.
    Citations: 1     Fields:    Translation:AnimalsCells
  2. Miller AL, Schissel S, Levy BD, Loscalzo J. Clinical problem-solving. A crazy cause of dyspnea. N Engl J Med. 2011 Jan 06; 364(1):72-7. PMID: 21208111.
    Citations: 1     Fields:    Translation:Humans
  3. Hunt S, Miller AL, Schissel S, Ross JJ. A crazy cause of dyspnea. N Engl J Med. 2010 Dec 16; 363(25):e38. PMID: 21158654.
    Citations: 1     Fields:    Translation:Humans
  4. Schissel SL, Dunsmore SE, Liu X, Shine RW, Perrella MA, Layne MD. Aortic carboxypeptidase-like protein is expressed in fibrotic human lung and its absence protects against bleomycin-induced lung fibrosis. Am J Pathol. 2009 Mar; 174(3):818-28. PMID: 19179605.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  5. Liu X, Ramjiganesh T, Chen YH, Chung SW, Hall SR, Schissel SL, Padera RF, Liao R, Ackerman KG, Kajstura J, Leri A, Anversa P, Yet SF, Layne MD, Perrella MA. Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice. Circulation. 2009 Jan 20; 119(2):261-8. PMID: 19118250.
    Citations: 21     Fields:    Translation:Animals
  6. Fredenburgh LE, Liang OD, Macias AA, Polte TR, Liu X, Riascos DF, Chung SW, Schissel SL, Ingber DE, Mitsialis SA, Kourembanas S, Perrella MA. Absence of cyclooxygenase-2 exacerbates hypoxia-induced pulmonary hypertension and enhances contractility of vascular smooth muscle cells. Circulation. 2008 Apr 22; 117(16):2114-22. PMID: 18391113.
    Citations: 31     Fields:    Translation:AnimalsCells
  7. Schissel SL, Layne MD. Telomerase, myofibroblasts, and pulmonary fibrosis. Am J Respir Cell Mol Biol. 2006 May; 34(5):520-2. PMID: 16618786.
    Citations: 8     Fields:    Translation:AnimalsCells
  8. Schissel SL and Layne MD. . Telomerase, myofibroblasts, and pulmonary fibrosis. American Journal of Respiratory Cell and Molecular Biology. 2006; 34(5):520-522.
  9. Schissel SL and Levy BD. Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS). Medical management of the surgical patient, edited by Michael F. Lubin. 2006; 142-157.
  10. Ira Tabas Scott L. Schissel Kevin Jon Williams. Method for treating a subject suffering from a condition associated with an extracellular zinc sphingomyelinase. 1999.
  11. Schissel SL, Keesler GA, Schuchman EH, Williams KJ, Tabas I. The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene. J Biol Chem. 1998 Jul 17; 273(29):18250-9. PMID: 9660788.
    Citations: 64     Fields:    Translation:AnimalsCells
  12. Jeong Ts, Schissel SL, Tabas I, Pownall HJ, Tall AR, Jiang X. Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase. J Clin Invest. 1998 Feb 15; 101(4):905-12. PMID: 9466986.
    Citations: 39     Fields:    Translation:Animals
  13. Marathe S, Schissel SL, Yellin MJ, Beatini N, Mintzer R, Williams KJ, Tabas I. Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell signaling. J Biol Chem. 1998 Feb 13; 273(7):4081-8. PMID: 9461601.
    Citations: 63     Fields:    Translation:HumansCells
  14. Schissel SL, Jiang X, Tweedie-Hardman J, Jeong T, Camejo EH, Najib J, Rapp JH, Williams KJ, Tabas I. Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development. J Biol Chem. 1998 Jan 30; 273(5):2738-46. PMID: 9446580.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  15. Schissel SL, Keesler GA, Schuchman EH, Williams KJ, and Tabas I. . The cellular trafficking and zinc-dependency of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene. Journal of Biological Chemistry. 1998; 273(29):18250 - 18259.
  16. Jeong T, Schissel SL, Tabas I, Pownall HJ, Tall AR, and Jiang X. . Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase. Journal of Clinical Investigation. 1998; 101(4):905 - 912.
  17. Schissel SL, Jiang X, Tweedie-Hardman J, Jeong T, Hurt-Camejo E, Najib J, Rapp JH, Williams KJ, and Tabas I. . Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Journal of Biological Chemistry. 1998; 273(5):2738 - 2746.
  18. Marathe S, Schissel SL, Yellin MJ, Beatini N, Mintzer R, Williams KJ, and Tabas I. . Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Journal of Biological Chemistry. 1998; 273(7):4081 - 4088.
  19. Schissel SL, Tweedie-Hardman J, Rapp JH, Graham G, Williams KJ, Tabas I. Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins. J Clin Invest. 1996 Sep 15; 98(6):1455-64. PMID: 8823312.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  20. Schissel SL, Schuchman EH, Williams KJ, Tabas I. Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene. J Biol Chem. 1996 Aug 02; 271(31):18431-6. PMID: 8702487.
    Citations: 73     Fields:    Translation:HumansAnimalsCells
  21. Skiba PJ, Zha X, Maxfield FR, Schissel SL, Tabas I. The distal pathway of lipoprotein-induced cholesterol esterification, but not sphingomyelinase-induced cholesterol esterification, is energy-dependent. J Biol Chem. 1996 Jun 07; 271(23):13392-400. PMID: 8662777.
    Citations: 14     Fields:    Translation:AnimalsCells
  22. Schissel SL, Tweedie-Hardman J, Rapp JH, Williams KJ, Graham G, and Tabas I. Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins. Journal of Clinical Investigation. 1996; 98(6):1455 - 1464.
  23. Schissel SL, Schuchman EH, Williams KJ, and Tabas I. . Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene. Journal of Biological Chemistry. 1996; 271(31):18431 - 18436.
  24. Skiba PJ, Zha X, Maxfield FR, Schissel SL, and Tabas I. . The distal pathway of lipoprotein-induced cholesterol esterification, but not sphingomyelinase-induced cholesterol esterification, is energy-dependent. Journal of Biological Chemistry. 1996; 271:13392 - 13400.
  25. Schissel SL, Beatini N, Zha X, Maxfield FR, Tabas I. Effect and cellular site of action of cysteine protease inhibitors on the cholesterol esterification pathway in macrophages and Chinese hamster ovary cells. Biochemistry. 1995 Aug 22; 34(33):10463-73. PMID: 7654700.
    Citations:    Fields:    Translation:AnimalsCells
  26. Schissel SL, Beatini N, Zha X, Maxfield FR, and Tabas I. . Effect and cellular site of action of cysteine protease inhibitors on the cholesterol esterification pathway in macrophages and chinese hamster ovary cells. Biochemistry. 1995; 34(33):10463 - 10473.
  27. Miller MW, Rosen SC, Schissel SL, Cropper EC, Kupfermann I, Weiss KR. A population of SCP-containing neurons in the buccal ganglion of Aplysia are radula mechanoafferents and receive excitation of central origin. J Neurosci. 1994 Nov; 14(11 Pt 2):7008-23. PMID: 7965095.
    Citations: 12     Fields:    Translation:AnimalsCells
  28. Newman GC, Hospod FE, Schissel SL. Ischemic brain slice glucose utilization: effects of slice thickness, acidosis, and K+. J Cereb Blood Flow Metab. 1991 May; 11(3):398-406. PMID: 2016347.
    Citations: 8     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Schissel's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (165)
Explore
_
Co-Authors (14)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
© 2021 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.