Harvard Catalyst Profiles

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Brian D. Polizzotti, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Nguyen T, Peng Y, Seekell RP, Kheir JN, Polizzotti BD. Hyperbaric polymer microcapsules for tunable oxygen delivery. J Control Release. 2020 11 10; 327:420-428. PMID: 32798637.
    Citations:    Fields:    
  2. Cole AR, Raza A, Ahmed H, Polizzotti BD, Padera RF, Andrews N, Kheir JN. Safety of inhaled hydrogen gas in healthy mice. Med Gas Res. 2019 Jul-Sep; 9(3):133-138. PMID: 31552876.
    Citations: 2     Fields:    Translation:Animals
  3. Cole AR, Perry DA, Raza A, Nedder AP, Pollack E, Regan WL, van den Bosch SJ, Polizzotti BD, Yang E, Davila D, Afacan O, Warfield SK, Ou Y, Sefton B, Everett AD, Neil JJ, Lidov HGW, Mayer JE, Kheir JN. Perioperatively Inhaled Hydrogen Gas Diminishes Neurologic Injury Following Experimental Circulatory Arrest in Swine. JACC Basic Transl Sci. 2019 Apr; 4(2):176-187. PMID: 31061920.
    Citations: 5     
  4. Mackin C, DeWitt ES, Black KJ, Tang X, Polizzotti BD, van den Bosch SJ, Alexander ME, Kheir JN. Intravenous Amiodarone and Sotalol Impair Contractility and Cardiac Output, but Procainamide Does Not: A Langendorff Study. J Cardiovasc Pharmacol Ther. 2019 05; 24(3):288-297. PMID: 30497293.
    Citations:    Fields:    Translation:Animals
  5. Peng Y, Li Q, Seekell RR, Kheir JN, Porter TM, Polizzotti BD. Tunable Nonlinear Acoustic Reporters Using Micro- and Nanosized Air Bubbles with Porous Polymeric Hard Shells. ACS Appl Mater Interfaces. 2019 Jan 09; 11(1):7-12. PMID: 30444111.
    Citations: 1     Fields:    
  6. Peng Y, Kheir JN, Polizzotti BD. Injectable Oxygen: Interfacing Materials Chemistry with Resuscitative Science. Chemistry. 2018 Dec 17; 24(71):18820-18829. PMID: 29952026.
    Citations: 1     Fields:    
  7. Perry DA, Thomson LM, Pigula FA, Polizzotti BD, DiNardo JA, Nedder A, Gauvreau K, Kheir JN. Changes in tissue oxygen tension, venous saturation, and Fick-based assessments of cardiac output during hyperoxia. Acta Anaesthesiol Scand. 2019 01; 63(1):93-100. PMID: 30109703.
    Citations: 1     Fields:    Translation:Animals
  8. Seekell RP, Peng Y, Lock AT, Kheir JN, Polizzotti BD. Tunable Polymer Microcapsules for Controlled Release of Therapeutic Gases. Langmuir. 2018 08 07; 34(31):9175-9183. PMID: 29989828.
    Citations:    Fields:    
  9. Nachman E, Clemensen P, Santos K, Cole AR, Polizzotti BD, Hofmann G, Leeman KT, van den Bosch SJ, Kheir JN. A Device for the Quantification of Oxygen Consumption and Caloric Expenditure in the Neonatal Range. Anesth Analg. 2018 07; 127(1):95-104. PMID: 29505450.
    Citations:    Fields:    Translation:HumansAnimals
  10. Kheir JN, Polizzotti BD, DiNardo JA. Use of Oxyhemoglobin Saturation or Oxygen Tension-an Unsolved Question-Reply. JAMA Pediatr. 2018 04 01; 172(4):390-391. PMID: 29404620.
    Citations:    Fields:    Translation:Humans
  11. Peng Y, Seekell RP, Cole AR, Lamothe JR, Lock AT, van den Bosch S, Tang X, Kheir JN, Polizzotti BD. Interfacial Nanoprecipitation toward Stable and Responsive Microbubbles and Their Use as a Resuscitative Fluid. Angew Chem Int Ed Engl. 2018 01 26; 57(5):1271-1276. PMID: 29230917.
    Citations:    Fields:    
  12. Ahmed H, Tang X, Polizzotti B, Gauvreau K, Kellogg M, DiNardo J, Kheir J. Use of Oxyhemoglobin Saturation, Rather Than Oxygen Tension, as a Marker of Oxygenation in Cyanotic Patients. JAMA Pediatr. 2017 10 01; 171(10):1012-1014. PMID: 28828474.
    Citations:    Fields:    Translation:Humans
  13. Perry DA, Salvin JW, Romfh P, Chen P, Krishnamurthy K, Thomson LM, Polizzotti BD, McGowan FX, Vakhshoori D, Kheir JN. Responsive monitoring of mitochondrial redox states in heart muscle predicts impending cardiac arrest. Sci Transl Med. 2017 Sep 20; 9(408). PMID: 28931652.
    Citations: 5     Fields:    Translation:AnimalsCells
  14. Zebrowski DC, Jensen CH, Becker R, Ferrazzi F, Baun C, Hvidsten S, Sheikh SP, Polizzotti BD, Andersen DC, Engel FB. Cardiac injury of the newborn mammalian heart accelerates cardiomyocyte terminal differentiation. Sci Rep. 2017 08 21; 7(1):8362. PMID: 28827644.
    Citations: 10     Fields:    Translation:AnimalsCells
  15. Black KJ, Lock AT, Thomson LM, Cole AR, Tang X, Polizzotti BD, Kheir JN. Hemodynamic Effects of Lipid-Based Oxygen Microbubbles via Rapid Intravenous Injection in Rodents. Pharm Res. 2017 Oct; 34(10):2156-2162. PMID: 28685297.
    Citations:    Fields:    Translation:HumansAnimals
  16. Kheir JN, Polizzotti BD. Reply to Span et al.: Rational design of oxygen microparticles for radiation therapy. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):E8010. PMID: 27930334.
    Citations: 1     Fields:    Translation:HumansCells
  17. Seekell RP, Lock AT, Peng Y, Cole AR, Perry DA, Kheir JN, Polizzotti BD. Oxygen delivery using engineered microparticles. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12380-12385. PMID: 27791101.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  18. Ganapathy B, Nandhagopal N, Polizzotti BD, Bennett D, Asan A, Wu Y, Kühn B. Neuregulin-1 Administration Protocols Sufficient for Stimulating Cardiac Regeneration in Young Mice Do Not Induce Somatic, Organ, or Neoplastic Growth. PLoS One. 2016; 11(5):e0155456. PMID: 27175488.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  19. Polizzotti BD, Ganapathy B, Haubner BJ, Penninger JM, Kühn B. A cryoinjury model in neonatal mice for cardiac translational and regeneration research. Nat Protoc. 2016 Mar; 11(3):542-52. PMID: 26890681.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  20. Polizzotti BD, Ganapathy B, Walsh S, Choudhury S, Ammanamanchi N, Bennett DG, dos Remedios CG, Haubner BJ, Penninger JM, Kühn B. Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window. Sci Transl Med. 2015 Apr 01; 7(281):281ra45. PMID: 25834111.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  21. Thomson LM, Polizzotti BD, McGowan FX, Kheir JN. Manufacture of concentrated, lipid-based oxygen microbubble emulsions by high shear homogenization and serial concentration. J Vis Exp. 2014 May 26; (87). PMID: 24894333.
    Citations: 2     Fields:    
  22. Polizzotti BD, Thomson LM, O'Connell DW, McGowan FX, Kheir JN. Optimization and characterization of stable lipid-based, oxygen-filled microbubbles by mixture design. . 2014 Aug; 102(6):1148-56. PMID: 24425069.
    Citations: 6     
  23. Bersell K, Choudhury S, Mollova M, Polizzotti BD, Ganapathy B, Walsh S, Wadugu B, Arab S, Kühn B. Moderate and high amounts of tamoxifen in aMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death. Dis Model Mech. 2013 Nov; 6(6):1459-69. PMID: 23929941.
    Citations: 44     Fields:    Translation:AnimalsCells
  24. Kheir JN, Polizzotti BD, Thomson LM, O'Connell DW, Black KJ, Lee RW, Wilking JN, Graham AC, Bell DC, McGowan FX. Bulk manufacture of concentrated oxygen gas-filled microparticles for intravenous oxygen delivery. Adv Healthc Mater. 2013 Aug; 2(8):1131-41. PMID: 23471884.
    Citations: 11     Fields:    Translation:AnimalsCells
  25. Polizzotti BD, Arab S, Kühn B. Intrapericardial delivery of gelfoam enables the targeted delivery of Periostin peptide after myocardial infarction by inducing fibrin clot formation. PLoS One. 2012; 7(5):e36788. PMID: 22590609.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  26. DeForest CA, Polizzotti BD, Anseth KS. Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments. Nat Mater. 2009 Aug; 8(8):659-64. PMID: 19543279.
    Citations: 189     Fields:    Translation:AnimalsCells
  27. Polizzotti BD, Fairbanks BD, Anseth KS. Three-dimensional biochemical patterning of click-based composite hydrogels via thiolene photopolymerization. Biomacromolecules. 2008 Apr; 9(4):1084-7. PMID: 18351741.
    Citations: 46     Fields:    
  28. Kent MS, Yim H, Murton JK, Sasaki DY, Polizzotti BD, Charati MB, Kiick KL, Kuzmenko I, Satija S. Synthetic polypeptide adsorption to Cu-IDA containing lipid films: a model for protein-membrane interactions. Langmuir. 2008 Feb 05; 24(3):932-42. PMID: 18179259.
    Citations: 2     Fields:    Translation:Cells
  29. Polizzotti BD, Maheshwari R, Vinkenborg J, Kiick KL. Effects of Saccharide Spacing and Chain Extension on Toxin Inhibition by Glycopolypeptides of Well-Defined Architecture. Macromolecules. 2007 Sep 11; 40(20):7103-7110. PMID: 19169374.
    Citations: 22     Fields:    
  30. Yim H, Kent MS, Sasaki DY, Polizzotti BD, Kiick KL, Majewski J, Satija S. Rearrangement of lipid ordered phases upon protein adsorption due to multiple site binding. Phys Rev Lett. 2006 May 19; 96(19):198101. PMID: 16803142.
    Citations: 3     Fields:    Translation:AnimalsCells
  31. Polizzotti BD, Kiick KL. Effects of polymer structure on the inhibition of cholera toxin by linear polypeptide-based glycopolymers. Biomacromolecules. 2006 Feb; 7(2):483-90. PMID: 16471920.
    Citations: 24     Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.