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profileBrian D. Polizzotti, Ph.D.

TitleAssistant Professor of Pediatrics
InstitutionBoston Children's Hospital
DepartmentPediatrics
AddressChildren's Hospital
Cardiology Rsch - Enders 13
300 Longwood Ave
Boston MA 02115
Phone617/919-2681
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nachman E, Clemensen P, Santos K, Cole AR, Polizzotti BD, Hofmann G, Leeman KT, van den Bosch SJ, Kheir JN. A Device for the Quantification of Oxygen Consumption and Caloric Expenditure in the Neonatal Range. Anesth Analg. 2018 Mar 01. PMID: 29505450.
    View in: PubMed
  2. Kheir JN, Polizzotti BD, DiNardo JA. Use of Oxyhemoglobin Saturation or Oxygen Tension-an Unsolved Question-Reply. JAMA Pediatr. 2018 Feb 05. PMID: 29404620.
    View in: PubMed
  3. Peng Y, Seekell RP, Cole AR, Lamothe JR, Lock AT, van den Bosch S, Tang X, Kheir JN, Polizzotti BD. Interfacial Nanoprecipitation toward Stable and Responsive Microbubbles and Their Use as a Resuscitative Fluid. Angew Chem Int Ed Engl. 2018 Jan 26; 57(5):1271-1276. PMID: 29230917.
    View in: PubMed
  4. Ahmed H, Tang X, Polizzotti B, Gauvreau K, Kellogg M, DiNardo J, Kheir J. Use of Oxyhemoglobin Saturation, Rather Than Oxygen Tension, as a Marker of Oxygenation in Cyanotic Patients. JAMA Pediatr. 2017 Oct 01; 171(10):1012-1014. PMID: 28828474.
    View in: PubMed
  5. Perry DA, Salvin JW, Romfh P, Chen P, Krishnamurthy K, Thomson LM, Polizzotti BD, McGowan FX, Vakhshoori D, Kheir JN. Responsive monitoring of mitochondrial redox states in heart muscle predicts impending cardiac arrest. Sci Transl Med. 2017 Sep 20; 9(408). PMID: 28931652.
    View in: PubMed
  6. Zebrowski DC, Jensen CH, Becker R, Ferrazzi F, Baun C, Hvidsten S, Sheikh SP, Polizzotti BD, Andersen DC, Engel FB. Cardiac injury of the newborn mammalian heart accelerates cardiomyocyte terminal differentiation. Sci Rep. 2017 Aug 21; 7(1):8362. PMID: 28827644.
    View in: PubMed
  7. Black KJ, Lock AT, Thomson LM, Cole AR, Tang X, Polizzotti BD, Kheir JN. Hemodynamic Effects of Lipid-Based Oxygen Microbubbles via Rapid Intravenous Injection in Rodents. Pharm Res. 2017 Oct; 34(10):2156-2162. PMID: 28685297.
    View in: PubMed
  8. Kheir JN, Polizzotti BD. Reply to Span et al.: Rational design of oxygen microparticles for radiation therapy. Proc Natl Acad Sci U S A. 2016 12 13; 113(50):E8010. PMID: 27930334.
    View in: PubMed
  9. Seekell RP, Lock AT, Peng Y, Cole AR, Perry DA, Kheir JN, Polizzotti BD. Oxygen delivery using engineered microparticles. Proc Natl Acad Sci U S A. 2016 11 01; 113(44):12380-12385. PMID: 27791101.
    View in: PubMed
  10. Ganapathy B, Nandhagopal N, Polizzotti BD, Bennett D, Asan A, Wu Y, Kühn B. Neuregulin-1 Administration Protocols Sufficient for Stimulating Cardiac Regeneration in Young Mice Do Not Induce Somatic, Organ, or Neoplastic Growth. PLoS One. 2016; 11(5):e0155456. PMID: 27175488; PMCID: PMC4866786.
  11. Polizzotti BD, Ganapathy B, Haubner BJ, Penninger JM, Kühn B. A cryoinjury model in neonatal mice for cardiac translational and regeneration research. Nat Protoc. 2016 Mar; 11(3):542-52. PMID: 26890681.
    View in: PubMed
  12. Polizzotti BD, Ganapathy B, Walsh S, Choudhury S, Ammanamanchi N, Bennett DG, dos Remedios CG, Haubner BJ, Penninger JM, Kühn B. Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window. Sci Transl Med. 2015 Apr 01; 7(281):281ra45. PMID: 25834111.
    View in: PubMed
  13. Thomson LM, Polizzotti BD, McGowan FX, Kheir JN. Manufacture of concentrated, lipid-based oxygen microbubble emulsions by high shear homogenization and serial concentration. J Vis Exp. 2014 May 26; (87). PMID: 24894333; PMCID: PMC4207250.
  14. Polizzotti BD, Thomson LM, O'Connell DW, McGowan FX, Kheir JN. Optimization and characterization of stable lipid-based, oxygen-filled microbubbles by mixture design. J Biomed Mater Res B Appl Biomater. 2014 Aug; 102(6):1148-56. PMID: 24425069.
    View in: PubMed
  15. Bersell K, Choudhury S, Mollova M, Polizzotti BD, Ganapathy B, Walsh S, Wadugu B, Arab S, Kühn B. Moderate and high amounts of tamoxifen in aMHC-MerCreMer mice induce a DNA damage response, leading to heart failure and death. Dis Model Mech. 2013 Nov; 6(6):1459-69. PMID: 23929941; PMCID: PMC3820268.
  16. Kheir JN, Polizzotti BD, Thomson LM, O'Connell DW, Black KJ, Lee RW, Wilking JN, Graham AC, Bell DC, McGowan FX. Bulk manufacture of concentrated oxygen gas-filled microparticles for intravenous oxygen delivery. Adv Healthc Mater. 2013 Aug; 2(8):1131-41. PMID: 23471884.
    View in: PubMed
  17. Polizzotti BD, Arab S, Kühn B. Intrapericardial delivery of gelfoam enables the targeted delivery of Periostin peptide after myocardial infarction by inducing fibrin clot formation. PLoS One. 2012; 7(5):e36788. PMID: 22590609; PMCID: PMC3349650.
  18. DeForest CA, Polizzotti BD, Anseth KS. Sequential click reactions for synthesizing and patterning three-dimensional cell microenvironments. Nat Mater. 2009 Aug; 8(8):659-64. PMID: 19543279; PMCID: PMC2715445.
  19. Polizzotti BD, Fairbanks BD, Anseth KS. Three-dimensional biochemical patterning of click-based composite hydrogels via thiolene photopolymerization. Biomacromolecules. 2008 Apr; 9(4):1084-7. PMID: 18351741.
    View in: PubMed
  20. Kent MS, Yim H, Murton JK, Sasaki DY, Polizzotti BD, Charati MB, Kiick KL, Kuzmenko I, Satija S. Synthetic polypeptide adsorption to Cu-IDA containing lipid films: a model for protein-membrane interactions. Langmuir. 2008 Feb 05; 24(3):932-42. PMID: 18179259; PMCID: PMC2896795.
  21. Polizzotti BD, Maheshwari R, Vinkenborg J, Kiick KL. Effects of Saccharide Spacing and Chain Extension on Toxin Inhibition by Glycopolypeptides of Well-Defined Architecture. Macromolecules. 2007 Sep 11; 40(20):7103-7110. PMID: 19169374.
    View in: PubMed
  22. Yim H, Kent MS, Sasaki DY, Polizzotti BD, Kiick KL, Majewski J, Satija S. Rearrangement of lipid ordered phases upon protein adsorption due to multiple site binding. Phys Rev Lett. 2006 May 19; 96(19):198101. PMID: 16803142; PMCID: PMC2893566.
  23. Polizzotti BD, Kiick KL. Effects of polymer structure on the inhibition of cholera toxin by linear polypeptide-based glycopolymers. Biomacromolecules. 2006 Feb; 7(2):483-90. PMID: 16471920; PMCID: PMC2657727.
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