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James Woodrow Weiss, M.D.

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Overview
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My career has focused on understanding the connection between exposure to intermittent or continuous hypoxia and sustained activation of the sympathetic nervous system which results in arterial hypertension. This interest has, over time, led us to patient studies of sleep apnea, investigations of normal volunteers exposed to a novel model of cyclic intermittent hypoxia (CIH), and animal studies using a rodent model of CIH. In recent years we have concentrated on understanding the mechanisms of peripheral chemoreflex plasticity and the contribution of the carotid chemoreceptor to sympathoexcitation. In particular, our laboratory now focuses on the contribution of glutamatergic transmission in the carotid body between glomus cells and between glomus cells and neurons to sustained sympathoexcitation after exposure to intermittent hypoxia. This interest reflects growing recognition that peripheral chemoreceptor plasticity is essential for a variety of forms of neurogenic hypertension.

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. R01HL074972 (WEISS, JAMES WOODROW) May 15, 2006 - Oct 31, 2011
    NIH
    Vascular Function after Exposure of Humans to Hypoxia
    Role: Principal Investigator
  2. R13HL078328 (WEISS, JAMES W) Aug 15, 2004 - Jul 31, 2005
    NIH
    Eigth International Conference on Sleep and Breathing
    Role: Principal Investigator
  3. R01HL075184 (WEISS, JAMES WOODROW) Sep 30, 2003 - May 31, 2008
    NIH
    Cartoid Mediators of Sympathoexcitation in Sleep Apnea
    Role: Principal Investigator
  4. R01HL072648 (WEISS, JAMES WOODROW) Aug 1, 2003 - May 31, 2008
    NIH
    Time Domains of Sympathetic Activity following Hypoxia
    Role: Principal Investigator
  5. P50HL060292 (SAPER, CLIFFORD) Sep 1, 1998 - Aug 31, 2008
    NIH
    Harvard Center on Sleep Neurobiology and Sleep Apnea (SCOR)
    Role: Co-Principal Investigator

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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.