Christopher Vincent Carman, Ph.D.
Harvard T.H. Chan School of Public Health
EH - Molecular+Integrative Phys Sci Prog
Beth Israel Deaconess Medical Center
330 Brookline Ave
Boston MA 02215
|University of New Hampshire, Durham, N.H.||B.S.||1994||Biochemistry|
|Thomas Jefferson University, Philadelphia, P.A.||Ph.D.||1999||Molecular Pharmacology & Structural Biology|
Major Research Interests: Adaptive & Innate Immune Cell Regulation and Trafficking
Specialties: Immunology, Inflammation, Vascular Biology, Immunomodulation, Bioengineering, Targeted Therapies
Our laboratory investigates the basic molecular and cell biological underpinnings of vascular inflammation and peripheral regulation of immune responses with special emphasis on leukocyte-endothelial interactions. Our studies also implement extensive molecular and cellular engineering approaches toward development of new immuno-modulation strategies for use in inflammatory, autoimmune, allogeneic and cancerous diseases.
Recently our studies have further focused on micro-environmental regulation of immunity and development of bioengineering approaches (e.g., in vitro chip, organoid and hypoxia technologies) as innovative platforms for studying tumor biology/immunology and for facilitating drug development.
Specific Topics we are currently investigating include:
The regulation of immune cell activation and migration
Peripheral regulation of adaptive and innate immune responses
Immuno-modulation of transplantation, autoimmunity and cancer
The cytoskeletal and biomechanical regulation of vascular integrity
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