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profileKlemen Strle, Ph.D.

TitleAssistant Professor of Medicine
InstitutionMassachusetts General Hospital
DepartmentMedicine
AddressMassachusetts General Hospital
Room 8301
149 13th Street
Charlestown MA 02129
Phone617/726-1532
Fax617/726-1544
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
K01AR062098     (STRLE, KLEMEN)Sep 17, 2012 - Aug 31, 2015
NIH/NIAMS
Defining Microbial and Host Factors in Innate Immune Responses in Lyme Arthritis
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pianta A, Arvikar SL, Strle K, Drouin EE, Wang Q, Costello CE, Steere AC. Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Invest. 2017 Aug 01; 127(8):2946-2956. PMID: 28650341.
    View in: PubMed
  2. Lochhead RB, Strle K, Kim ND, Kohler MJ, Arvikar SL, Aversa JM, Steere AC. MicroRNA Expression Shows Inflammatory Dysregulation and Tumor-Like Proliferative Responses in Joints of Patients With Postinfectious Lyme Arthritis. Arthritis Rheumatol. 2017 May; 69(5):1100-1110. PMID: 28076897.
    View in: PubMed
  3. Branda JA, Strle K, Nigrovic LE, Lantos PM, Lepore TJ, Damle NS, Ferraro MJ, Steere AC. Evaluation of Modified 2-Tiered Serodiagnostic Testing Algorithms for Early Lyme Disease. Clin Infect Dis. 2017 04 15; 64(8):1074-1080. PMID: 28329259.
    View in: PubMed
  4. Pianta A, Arvikar S, Strle K, Drouin EE, Wang Q, Costello CE, Steere AC. Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2017 May; 69(5):964-975. PMID: 27863183.
    View in: PubMed
  5. Strle K, Sulka KB, Pianta A, Crowley JT, Arvikar SL, Anselmo A, Sadreyev R, Steere AC. T-Helper 17 Cell Cytokine Responses in Lyme Disease Correlate With Borrelia burgdorferi Antibodies During Early Infection and With Autoantibodies Late in the Illness in Patients With Antibiotic-Refractory Lyme Arthritis. Clin Infect Dis. 2017 Apr 01; 64(7):930-938. PMID: 28077518.
    View in: PubMed
  6. Miyabe C, Miyabe Y, Strle K, Kim ND, Stone JH, Luster AD, Unizony S. An expanded population of pathogenic regulatory T cells in giant cell arteritis is abrogated by IL-6 blockade therapy. Ann Rheum Dis. 2017 May; 76(5):898-905. PMID: 27927642.
    View in: PubMed
  7. Cerar T, Strle F, Stupica D, Ruzic-Sabljic E, McHugh G, Steere AC, Strle K. Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States. Emerg Infect Dis. 2016 May; 22(5):818-27. PMID: 27088349; PMCID: PMC4861522.
  8. Crowley JT, Strle K, Drouin EE, Pianta A, Arvikar SL, Wang Q, Costello CE, Steere AC. Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis. J Autoimmun. 2016 May; 69:24-37. PMID: 26922382; PMCID: PMC4826816 [Available on 05/01/17].
  9. Pianta A, Drouin EE, Crowley JT, Arvikar S, Strle K, Costello CE, Steere AC. Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis. Clin Immunol. 2015 Oct; 160(2):336-41. PMID: 26187145; PMCID: PMC4582008 [Available on 10/01/16].
  10. Crowley JT, Drouin EE, Pianta A, Strle K, Wang Q, Costello CE, Steere AC. A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients With Lyme Disease. J Infect Dis. 2015 Dec 01; 212(11):1841-50. PMID: 26014802; PMCID: PMC4633766 [Available on 12/01/16].
  11. Londoño D, Cadavid D, Drouin EE, Strle K, McHugh G, Aversa JM, Steere AC. Antibodies to endothelial cell growth factor and obliterative microvascular lesions in the synovium of patients with antibiotic-refractory lyme arthritis. Arthritis Rheumatol. 2014 Aug; 66(8):2124-33. PMID: 24623727; PMCID: PMC4211115.
  12. Strle K, Stupica D, Drouin EE, Steere AC, Strle F. Reply to Seligman et Al. Clin Infect Dis. 2014 Sep 01; 59(5):747-8. PMID: 24812297.
    View in: PubMed
  13. Strle K, Stupica D, Drouin EE, Steere AC, Strle F. Reply to Parvu and Parvu. Clin Infect Dis. 2014 Apr; 58(8):1200. PMID: 24470277.
    View in: PubMed
  14. Strle K, Stupica D, Drouin EE, Steere AC, Strle F. Elevated levels of IL-23 in a subset of patients with post-lyme disease symptoms following erythema migrans. Clin Infect Dis. 2014 Feb; 58(3):372-80. PMID: 24218102; PMCID: PMC3890340.
  15. Li X, Strle K, Wang P, Acosta DI, McHugh GA, Sikand N, Strle F, Steere AC. Tick-specific borrelial antigens appear to be upregulated in American but not European patients with Lyme arthritis, a late manifestation of Lyme borreliosis. J Infect Dis. 2013 Sep; 208(6):934-41. PMID: 23766526; PMCID: PMC3749008.
  16. Vudattu NK, Strle K, Steere AC, Drouin EE. Dysregulation of CD4+CD25(high) T cells in the synovial fluid of patients with antibiotic-refractory Lyme arthritis. Arthritis Rheum. 2013 Jun; 65(6):1643-53. PMID: 23450683; PMCID: PMC3672381.
  17. Branda JA, Strle F, Strle K, Sikand N, Ferraro MJ, Steere AC. Performance of United States serologic assays in the diagnosis of Lyme borreliosis acquired in Europe. Clin Infect Dis. 2013 Aug; 57(3):333-40. PMID: 23592827.
    View in: PubMed
  18. Drouin EE, Seward RJ, Strle K, McHugh G, Katchar K, Londoño D, Yao C, Costello CE, Steere AC. A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease. Arthritis Rheum. 2013 Jan; 65(1):186-96. PMID: 23044924; PMCID: PMC3535550.
  19. Arvikar SL, Collier DS, Fisher MC, Unizony S, Cohen GL, McHugh G, Kawai T, Strle K, Steere AC. Clinical correlations with Porphyromonas gingivalis antibody responses in patients with early rheumatoid arthritis. Arthritis Res Ther. 2013; 15(5):R109. PMID: 24017968; PMCID: PMC3978628.
  20. Wang Z, Cheng Z, Cristofaro V, Li J, Xiao X, Gomez P, Ge R, Gong E, Strle K, Sullivan MP, Adam RM, White MF, Olumi AF. Inhibition of TNF-a improves the bladder dysfunction that is associated with type 2 diabetes. Diabetes. 2012 Aug; 61(8):2134-45. PMID: 22688336; PMCID: PMC3402324.
  21. Strle K, Shin JJ, Glickstein LJ, Steere AC. Association of a Toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis. Arthritis Rheum. 2012 May; 64(5):1497-507. PMID: 22246581; PMCID: PMC3338893.
  22. Strle K, Jones KL, Drouin EE, Li X, Steere AC. Borrelia burgdorferi RST1 (OspC type A) genotype is associated with greater inflammation and more severe Lyme disease. Am J Pathol. 2011 Jun; 178(6):2726-39. PMID: 21641395; PMCID: PMC3123987.
  23. Londoño D, Carvajal J, Strle K, Kim KS, Cadavid D. IL-10 Prevents apoptosis of brain endothelium during bacteremia. J Immunol. 2011 Jun 15; 186(12):7176-86. PMID: 21602495.
    View in: PubMed
  24. Shin JJ, Strle K, Glickstein LJ, Luster AD, Steere AC. Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis. Arthritis Res Ther. 2010; 12(5):R168. PMID: 20828409; PMCID: PMC2990995.
  25. Shen S, Shin JJ, Strle K, McHugh G, Li X, Glickstein LJ, Drouin EE, Steere AC. Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis. Arthritis Rheum. 2010 Jul; 62(7):2127-37. PMID: 20506317; PMCID: PMC2913315.
  26. Strle K, Drouin EE, Shen S, El Khoury J, McHugh G, Ruzic-Sabljic E, Strle F, Steere AC. Borrelia burgdorferi stimulates macrophages to secrete higher levels of cytokines and chemokines than Borrelia afzelii or Borrelia garinii. J Infect Dis. 2009 Dec 15; 200(12):1936-43. PMID: 19909078; PMCID: PMC2783242.
  27. O'Connor JC, McCusker RH, Strle K, Johnson RW, Dantzer R, Kelley KW. Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology. Cell Immunol. 2008 Mar-Apr; 252(1-2):91-110. PMID: 18325486; PMCID: PMC2615236.
  28. Palin K, McCusker RH, Strle K, Moos F, Dantzer R, Kelley KW. Tumor necrosis factor-alpha-induced sickness behavior is impaired by central administration of an inhibitor of c-jun N-terminal kinase. Psychopharmacology (Berl). 2008 May; 197(4):629-35. PMID: 18274729; PMCID: PMC2924630.
  29. Strle K, McCusker RH, Johnson RW, Zunich SM, Dantzer R, Kelley KW. Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1beta. Am J Physiol Endocrinol Metab. 2008 Apr; 294(4):E709-18. PMID: 18270299; PMCID: PMC2951888.
  30. Strle K, McCusker RH, Tran L, King A, Johnson RW, Freund GG, Dantzer R, Kelley KW. Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts. J Neuroimmunol. 2007 Aug; 188(1-2):48-55. PMID: 17572510; PMCID: PMC2078530.
  31. Strle K, Broussard SR, McCusker RH, Shen WH, LeCleir JM, Johnson RW, Freund GG, Dantzer R, Kelley KW. C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts. Endocrinology. 2006 Sep; 147(9):4363-73. PMID: 16777978.
    View in: PubMed
  32. Strle K, Broussard SR, McCusker RH, Shen WH, Johnson RW, Freund GG, Dantzer R, Kelley KW. Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide. Endocrinology. 2004 Oct; 145(10):4592-602. PMID: 15256490.
    View in: PubMed
  33. Broussard SR, McCusker RH, Novakofski JE, Strle K, Shen WH, Johnson RW, Dantzer R, Kelley KW. IL-1beta impairs insulin-like growth factor i-induced differentiation and downstream activation signals of the insulin-like growth factor i receptor in myoblasts. J Immunol. 2004 Jun 15; 172(12):7713-20. PMID: 15187154.
    View in: PubMed
  34. Shen WH, Jackson ST, Broussard SR, McCusker RH, Strle K, Freund GG, Johnson RW, Dantzer R, Kelley KW. IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells. J Immunol. 2004 Jun 15; 172(12):7272-81. PMID: 15187102.
    View in: PubMed
  35. Broussard SR, McCusker RH, Novakofski JE, Strle K, Shen WH, Johnson RW, Freund GG, Dantzer R, Kelley KW. Cytokine-hormone interactions: tumor necrosis factor alpha impairs biologic activity and downstream activation signals of the insulin-like growth factor I receptor in myoblasts. Endocrinology. 2003 Jul; 144(7):2988-96. PMID: 12810554.
    View in: PubMed
  36. Strle K, Zhou JH, Broussard SR, Venters HD, Johnson RW, Freund GG, Dantzer R, Kelley KW. IL-10 promotes survival of microglia without activating Akt. J Neuroimmunol. 2002 Jan; 122(1-2):9-19. PMID: 11777539.
    View in: PubMed
  37. Zhou JH, Broussard SR, Strle K, Freund GG, Johnson RW, Dantzer R, Kelley KW. IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase. J Immunol. 2001 Oct 15; 167(8):4436-42. PMID: 11591769.
    View in: PubMed
  38. Strle K, Zhou JH, Shen WH, Broussard SR, Johnson RW, Freund GG, Dantzer R, Kelley KW. Interleukin-10 in the brain. Crit Rev Immunol. 2001; 21(5):427-49. PMID: 11942558.
    View in: PubMed
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