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Klemen Strle, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AI144916 (STRLE, KLEMEN) Mar 5, 2019 - Feb 28, 2021
    Defining Host Genetic Factors in Adverse Clinical Outcomes in Lyme Disease
    Role: Principal Investigator
  2. K01AR062098 (STRLE, KLEMEN) Sep 17, 2012 - Aug 31, 2015
    Defining Microbial and Host Factors in Innate Immune Responses in Lyme Arthritis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Bogovic P, Lusa L, Korva M, Pavletic M, Rus KR, Lotric-Furlan S, Avšic-Županc T, Strle K, Strle F. Inflammatory Immune Responses in the Pathogenesis of Tick-Borne Encephalitis. J Clin Med. 2019 May 22; 8(5). PMID: 31121969.
  2. Reinink P, Souter MNT, Cheng TY, van Gorkom T, Lenz S, Kubler-Kielb J, Strle K, Kremer K, Thijsen SFT, Steere AC, Godfrey DI, Pellicci DG, Moody DB, Van Rhijn I. CD1b presents self and Borrelia burgdorferi diacylglycerols to human T cells. Eur J Immunol. 2019 May; 49(5):737-746. PMID: 30854633.
  3. Lochhead RB, Ordoñez D, Arvikar SL, Aversa JM, Oh LS, Heyworth B, Sadreyev R, Steere AC, Strle K. Interferon-gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast-like synoviocytes into immune effector cells. Cell Microbiol. 2019 Feb; 21(2):e12992. PMID: 30550623.
    Citations:    Fields:    
  4. Lochhead RB, Arvikar SL, Aversa JM, Sadreyev RI, Strle K, Steere AC. Robust interferon signature and suppressed tissue repair gene expression in synovial tissue from patients with postinfectious, Borrelia burgdorferi-induced Lyme arthritis. Cell Microbiol. 2019 Feb; 21(2):e12954. PMID: 30218476.
    Citations:    Fields:    
  5. Bogovic P, Lusa L, Stupica D, Rojko T, Korva M, Avšic-Županc T, Strle K, Wormser GP, Strle F. Impact of pre-existing treatment with statins on the course and outcome of tick-borne encephalitis. PLoS One. 2018; 13(10):e0204773. PMID: 30286159.
    Citations:    Fields:    
  6. Sulka KB, Strle K, Crowley JT, Lochhead RB, Anthony R, Steere AC. Correlation of Lyme Disease-Associated IgG4 Autoantibodies With Synovial Pathology in Antibiotic-Refractory Lyme Arthritis. Arthritis Rheumatol. 2018 Nov; 70(11):1835-1846. PMID: 29790305.
    Citations:    Fields:    
  7. Sahay B, Bashant K, Nelson NLJ, Patsey RL, Gadila SK, Boohaker R, Verma A, Strle K, Sellati TJ. Induction of Interleukin 10 by Borrelia burgdorferi Is Regulated by the Action of CD14-Dependent p38 Mitogen-Activated Protein Kinase and cAMP-Mediated Chromatin Remodeling. Infect Immun. 2018 04; 86(4). PMID: 29311239.
    Citations:    Fields:    Translation:AnimalsCells
  8. Pianta A, Arvikar SL, Strle K, Drouin EE, Wang Q, Costello CE, Steere AC. Two rheumatoid arthritis-specific autoantigens correlate microbial immunity with autoimmune responses in joints. J Clin Invest. 2017 Aug 01; 127(8):2946-2956. PMID: 28650341.
    Citations: 9     Fields:    Translation:HumansCells
  9. Lochhead RB, Strle K, Kim ND, Kohler MJ, Arvikar SL, Aversa JM, Steere AC. MicroRNA Expression Shows Inflammatory Dysregulation and Tumor-Like Proliferative Responses in Joints of Patients With Postinfectious Lyme Arthritis. Arthritis Rheumatol. 2017 05; 69(5):1100-1110. PMID: 28076897.
    Citations: 2     Fields:    Translation:Humans
  10. Branda JA, Strle K, Nigrovic LE, Lantos PM, Lepore TJ, Damle NS, Ferraro MJ, Steere AC. Evaluation of Modified 2-Tiered Serodiagnostic Testing Algorithms for Early Lyme Disease. Clin Infect Dis. 2017 04 15; 64(8):1074-1080. PMID: 28329259.
    Citations: 5     Fields:    Translation:Humans
  11. Pianta A, Arvikar S, Strle K, Drouin EE, Wang Q, Costello CE, Steere AC. Evidence of the Immune Relevance of Prevotella copri, a Gut Microbe, in Patients With Rheumatoid Arthritis. Arthritis Rheumatol. 2017 05; 69(5):964-975. PMID: 27863183.
    Citations: 11     Fields:    Translation:HumansCells
  12. Strle K, Sulka KB, Pianta A, Crowley JT, Arvikar SL, Anselmo A, Sadreyev R, Steere AC. T-Helper 17 Cell Cytokine Responses in Lyme Disease Correlate With Borrelia burgdorferi Antibodies During Early Infection and With Autoantibodies Late in the Illness in Patients With Antibiotic-Refractory Lyme Arthritis. Clin Infect Dis. 2017 Apr 01; 64(7):930-938. PMID: 28077518.
    Citations: 3     Fields:    Translation:HumansCells
  13. Miyabe C, Miyabe Y, Strle K, Kim ND, Stone JH, Luster AD, Unizony S. An expanded population of pathogenic regulatory T cells in giant cell arteritis is abrogated by IL-6 blockade therapy. Ann Rheum Dis. 2017 May; 76(5):898-905. PMID: 27927642.
    Citations: 4     Fields:    Translation:HumansCells
  14. Cerar T, Strle F, Stupica D, Ruzic-Sabljic E, McHugh G, Steere AC, Strle K. Differences in Genotype, Clinical Features, and Inflammatory Potential of Borrelia burgdorferi sensu stricto Strains from Europe and the United States. Emerg Infect Dis. 2016 May; 22(5):818-27. PMID: 27088349.
    Citations: 12     Fields:    Translation:HumansCells
  15. Crowley JT, Strle K, Drouin EE, Pianta A, Arvikar SL, Wang Q, Costello CE, Steere AC. Matrix metalloproteinase-10 is a target of T and B cell responses that correlate with synovial pathology in patients with antibiotic-refractory Lyme arthritis. J Autoimmun. 2016 May; 69:24-37. PMID: 26922382.
    Citations: 9     Fields:    Translation:HumansCells
  16. Pianta A, Drouin EE, Crowley JT, Arvikar S, Strle K, Costello CE, Steere AC. Annexin A2 is a target of autoimmune T and B cell responses associated with synovial fibroblast proliferation in patients with antibiotic-refractory Lyme arthritis. Clin Immunol. 2015 Oct; 160(2):336-41. PMID: 26187145.
    Citations: 11     Fields:    Translation:HumansCells
  17. Crowley JT, Drouin EE, Pianta A, Strle K, Wang Q, Costello CE, Steere AC. A Highly Expressed Human Protein, Apolipoprotein B-100, Serves as an Autoantigen in a Subgroup of Patients With Lyme Disease. J Infect Dis. 2015 Dec 01; 212(11):1841-50. PMID: 26014802.
    Citations: 13     Fields:    Translation:HumansCells
  18. Londoño D, Cadavid D, Drouin EE, Strle K, McHugh G, Aversa JM, Steere AC. Antibodies to endothelial cell growth factor and obliterative microvascular lesions in the synovium of patients with antibiotic-refractory lyme arthritis. Arthritis Rheumatol. 2014 Aug; 66(8):2124-33. PMID: 24623727.
    Citations: 10     Fields:    Translation:Humans
  19. Strle K, Stupica D, Drouin EE, Steere AC, Strle F. Reply to Seligman et Al. Clin Infect Dis. 2014 Sep 01; 59(5):747-8. PMID: 24812297.
    Citations:    Fields:    Translation:Humans
  20. Strle K, Stupica D, Drouin EE, Steere AC, Strle F. Reply to Parvu and Parvu. Clin Infect Dis. 2014 Apr; 58(8):1200. PMID: 24470277.
    Citations:    Fields:    Translation:Humans
  21. Strle K, Stupica D, Drouin EE, Steere AC, Strle F. Elevated levels of IL-23 in a subset of patients with post-lyme disease symptoms following erythema migrans. Clin Infect Dis. 2014 Feb; 58(3):372-80. PMID: 24218102.
    Citations: 16     Fields:    Translation:HumansCells
  22. Li X, Strle K, Wang P, Acosta DI, McHugh GA, Sikand N, Strle F, Steere AC. Tick-specific borrelial antigens appear to be upregulated in American but not European patients with Lyme arthritis, a late manifestation of Lyme borreliosis. J Infect Dis. 2013 Sep; 208(6):934-41. PMID: 23766526.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  23. Vudattu NK, Strle K, Steere AC, Drouin EE. Dysregulation of CD4+CD25(high) T cells in the synovial fluid of patients with antibiotic-refractory Lyme arthritis. Arthritis Rheum. 2013 Jun; 65(6):1643-53. PMID: 23450683.
    Citations: 16     Fields:    Translation:HumansCells
  24. Branda JA, Strle F, Strle K, Sikand N, Ferraro MJ, Steere AC. Performance of United States serologic assays in the diagnosis of Lyme borreliosis acquired in Europe. Clin Infect Dis. 2013 Aug; 57(3):333-40. PMID: 23592827.
    Citations: 23     Fields:    Translation:Humans
  25. Drouin EE, Seward RJ, Strle K, McHugh G, Katchar K, Londoño D, Yao C, Costello CE, Steere AC. A novel human autoantigen, endothelial cell growth factor, is a target of T and B cell responses in patients with Lyme disease. Arthritis Rheum. 2013 Jan; 65(1):186-96. PMID: 23044924.
    Citations: 23     Fields:    Translation:HumansCells
  26. Arvikar SL, Collier DS, Fisher MC, Unizony S, Cohen GL, McHugh G, Kawai T, Strle K, Steere AC. Clinical correlations with Porphyromonas gingivalis antibody responses in patients with early rheumatoid arthritis. Arthritis Res Ther. 2013; 15(5):R109. PMID: 24017968.
    Citations: 14     Fields:    Translation:HumansCells
  27. Wang Z, Cheng Z, Cristofaro V, Li J, Xiao X, Gomez P, Ge R, Gong E, Strle K, Sullivan MP, Adam RM, White MF, Olumi AF. Inhibition of TNF-a improves the bladder dysfunction that is associated with type 2 diabetes. Diabetes. 2012 Aug; 61(8):2134-45. PMID: 22688336.
    Citations: 15     Fields:    Translation:AnimalsCells
  28. Strle K, Shin JJ, Glickstein LJ, Steere AC. Association of a Toll-like receptor 1 polymorphism with heightened Th1 inflammatory responses and antibiotic-refractory Lyme arthritis. Arthritis Rheum. 2012 May; 64(5):1497-507. PMID: 22246581.
    Citations: 35     Fields:    Translation:HumansCells
  29. Strle K, Jones KL, Drouin EE, Li X, Steere AC. Borrelia burgdorferi RST1 (OspC type A) genotype is associated with greater inflammation and more severe Lyme disease. Am J Pathol. 2011 Jun; 178(6):2726-39. PMID: 21641395.
    Citations: 29     Fields:    Translation:HumansCells
  30. Londoño D, Carvajal J, Strle K, Kim KS, Cadavid D. IL-10 Prevents apoptosis of brain endothelium during bacteremia. J Immunol. 2011 Jun 15; 186(12):7176-86. PMID: 21602495.
    Citations: 11     Fields:    Translation:HumansAnimals
  31. Shin JJ, Strle K, Glickstein LJ, Luster AD, Steere AC. Borrelia burgdorferi stimulation of chemokine secretion by cells of monocyte lineage in patients with Lyme arthritis. Arthritis Res Ther. 2010; 12(5):R168. PMID: 20828409.
    Citations: 7     Fields:    Translation:HumansCells
  32. Shen S, Shin JJ, Strle K, McHugh G, Li X, Glickstein LJ, Drouin EE, Steere AC. Treg cell numbers and function in patients with antibiotic-refractory or antibiotic-responsive Lyme arthritis. Arthritis Rheum. 2010 Jul; 62(7):2127-37. PMID: 20506317.
    Citations: 23     Fields:    Translation:HumansCells
  33. Strle K, Drouin EE, Shen S, El Khoury J, McHugh G, Ruzic-Sabljic E, Strle F, Steere AC. Borrelia burgdorferi stimulates macrophages to secrete higher levels of cytokines and chemokines than Borrelia afzelii or Borrelia garinii. J Infect Dis. 2009 Dec 15; 200(12):1936-43. PMID: 19909078.
    Citations: 22     Fields:    Translation:HumansCells
  34. O'Connor JC, McCusker RH, Strle K, Johnson RW, Dantzer R, Kelley KW. Regulation of IGF-I function by proinflammatory cytokines: at the interface of immunology and endocrinology. Cell Immunol. 2008 Mar-Apr; 252(1-2):91-110. PMID: 18325486.
    Citations: 55     Fields:    Translation:HumansAnimals
  35. Palin K, McCusker RH, Strle K, Moos F, Dantzer R, Kelley KW. Tumor necrosis factor-alpha-induced sickness behavior is impaired by central administration of an inhibitor of c-jun N-terminal kinase. Psychopharmacology (Berl). 2008 May; 197(4):629-35. PMID: 18274729.
    Citations: 9     Fields:    Translation:AnimalsCells
  36. Strle K, McCusker RH, Johnson RW, Zunich SM, Dantzer R, Kelley KW. Prototypical anti-inflammatory cytokine IL-10 prevents loss of IGF-I-induced myogenin protein expression caused by IL-1beta. Am J Physiol Endocrinol Metab. 2008 Apr; 294(4):E709-18. PMID: 18270299.
    Citations: 7     Fields:    Translation:AnimalsCells
  37. Strle K, McCusker RH, Tran L, King A, Johnson RW, Freund GG, Dantzer R, Kelley KW. Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts. J Neuroimmunol. 2007 Aug; 188(1-2):48-55. PMID: 17572510.
    Citations: 12     Fields:    Translation:AnimalsCells
  38. Strle K, Broussard SR, McCusker RH, Shen WH, LeCleir JM, Johnson RW, Freund GG, Dantzer R, Kelley KW. C-jun N-terminal kinase mediates tumor necrosis factor-alpha suppression of differentiation in myoblasts. Endocrinology. 2006 Sep; 147(9):4363-73. PMID: 16777978.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  39. Strle K, Broussard SR, McCusker RH, Shen WH, Johnson RW, Freund GG, Dantzer R, Kelley KW. Proinflammatory cytokine impairment of insulin-like growth factor I-induced protein synthesis in skeletal muscle myoblasts requires ceramide. Endocrinology. 2004 Oct; 145(10):4592-602. PMID: 15256490.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  40. Broussard SR, McCusker RH, Novakofski JE, Strle K, Shen WH, Johnson RW, Dantzer R, Kelley KW. IL-1beta impairs insulin-like growth factor i-induced differentiation and downstream activation signals of the insulin-like growth factor i receptor in myoblasts. J Immunol. 2004 Jun 15; 172(12):7713-20. PMID: 15187154.
    Citations: 25     Fields:    Translation:AnimalsCells
  41. Shen WH, Jackson ST, Broussard SR, McCusker RH, Strle K, Freund GG, Johnson RW, Dantzer R, Kelley KW. IL-1beta suppresses prolonged Akt activation and expression of E2F-1 and cyclin A in breast cancer cells. J Immunol. 2004 Jun 15; 172(12):7272-81. PMID: 15187102.
    Citations: 6     Fields:    Translation:HumansCells
  42. Broussard SR, McCusker RH, Novakofski JE, Strle K, Shen WH, Johnson RW, Freund GG, Dantzer R, Kelley KW. Cytokine-hormone interactions: tumor necrosis factor alpha impairs biologic activity and downstream activation signals of the insulin-like growth factor I receptor in myoblasts. Endocrinology. 2003 Jul; 144(7):2988-96. PMID: 12810554.
    Citations: 15     Fields:    Translation:AnimalsCells
  43. Strle K, Zhou JH, Broussard SR, Venters HD, Johnson RW, Freund GG, Dantzer R, Kelley KW. IL-10 promotes survival of microglia without activating Akt. J Neuroimmunol. 2002 Jan; 122(1-2):9-19. PMID: 11777539.
    Citations: 20     Fields:    Translation:AnimalsCells
  44. Zhou JH, Broussard SR, Strle K, Freund GG, Johnson RW, Dantzer R, Kelley KW. IL-10 inhibits apoptosis of promyeloid cells by activating insulin receptor substrate-2 and phosphatidylinositol 3'-kinase. J Immunol. 2001 Oct 15; 167(8):4436-42. PMID: 11591769.
    Citations: 17     Fields:    Translation:Cells
  45. Strle K, Zhou JH, Shen WH, Broussard SR, Johnson RW, Freund GG, Dantzer R, Kelley KW. Interleukin-10 in the brain. Crit Rev Immunol. 2001; 21(5):427-49. PMID: 11942558.
    Citations: 104     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.