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Ruvandhi Nathavitharana, M.B.,B.S.


Available: 10/15/20, Expires: 10/15/21

TB is the leading cause of death due to an infectious disease globally. TB transmission from patients with unsuspected disease is the major driver of TB incidence. Dr. Nathavitharana’s research interests center around using implementation science to improve TB care delivery and decrease TB transmission. Dr. Nathavitharana is also the Vice Chair of TB Proof, an organization that seeks to directly involve communities affected by TB to advocate for high quality TB prevention and care, informed by the latest research.

Potential HMS student projects include analyses of the diagnostic accuracy of TB tests, analyses of risk factors for TB transmission among health care workers, scoping and systematic reviews, and advocacy opportunities. Work can be done remotely.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K23AI132648 (NATHAVITHARANA, RUVANDHI) Mar 1, 2018 - Feb 28, 2023
    Optimizing Diagnostic Strategies for TB Transmission Control in Health-Care Facilities
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Jhaveri VV, Singhal D, Riedel S, Rowley CF, Nathavitharana RR. Surgical cure of clarithromycin resistant Mycobacterium chelonae breast implant infection: A case report and review of the literature. J Clin Tuberc Other Mycobact Dis. 2020 Dec; 21:100183. PMID: 32964146.
  2. Nardell EA, Nathavitharana RR. Airborne Spread of SARS-CoV-2 and a Potential Role for Air Disinfection. JAMA. 2020 07 14; 324(2):141-142. PMID: 32478797.
    Citations: 7     Fields:    Translation:HumansCellsPHPublic Health
  3. Nathavitharana RR, Patel PK, Tierney DB, Mehrotra P, Lederer PA, Davis S, Nardell E. Innovation and Knowledge Sharing Can Transform COVID-19 Infection Prevention Response. J Hosp Med. 2020 05; 15(5):299-301. PMID: 32379035.
    Citations:    Fields:    Translation:HumansPHPublic Health
  4. Nardell E, Lederer P, Mishra H, Nathavitharana R, Theron G. Cool but dangerous: How climate change is increasing the risk of airborne infections. Indoor Air. 2020 03; 30(2):195-197. PMID: 32100390.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  5. Chakaya JM, Marais B, du Cros P, Ntoumi F, Mfinanga S, Kapata N, Hasnain SE, Nathavitharana R, Zumla A. Programmatic versus personalised approaches to managing the global epidemic of multidrug-resistant tuberculosis. Lancet Respir Med. 2020 04; 8(4):334-335. PMID: 32113573.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  6. Subbaraman R, Jhaveri T, Nathavitharana RR. Closing gaps in the tuberculosis care cascade: an action-oriented research agenda. J Clin Tuberc Other Mycobact Dis. 2020 May; 19:100144. PMID: 32072022.
    Citations: 1     
  7. Cocozza AM, Linh NN, Nathavitharana RR, Ahmad U, Jaramillo E, Gargioni GEM, Fox GJ. An assessment of current tuberculosis patient care and support policies in high-burden countries. Int J Tuberc Lung Dis. 2020 01 01; 24(1):36-42. PMID: 32005305.
    Citations:    Fields:    
  8. Bjerrum S, Schiller I, Dendukuri N, Kohli M, Nathavitharana RR, Zwerling AA, Denkinger CM, Steingart KR, Shah M. Lateral flow urine lipoarabinomannan assay for detecting active tuberculosis in people living with HIV. Cochrane Database Syst Rev. 2019 Oct 21; 10:CD011420. PMID: 31633805.
    Citations: 6     Fields:    
  9. Nathavitharana RR, Yoon C, Macpherson P, Dowdy DW, Cattamanchi A, Somoskovi A, Broger T, Ottenhoff THM, Arinaminpathy N, Lonnroth K, Reither K, Cobelens F, Gilpin C, Denkinger CM, Schumacher SG. Guidance for Studies Evaluating the Accuracy of Tuberculosis Triage Tests. J Infect Dis. 2019 10 08; 220(220 Suppl 3):S116-S125. PMID: 31593600.
    Citations: 1     Fields:    Translation:HumansCells
  10. Nardell E, Nathavitharana R. Air disinfection in measles transmission hotspots. Lancet. 2019 Sep 21; 394(10203):1009-1010. PMID: 31495498.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  11. Harris M, Qi A, Jeagal L, Torabi N, Menzies D, Korobitsyn A, Pai M, Nathavitharana RR, Ahmad Khan F. A systematic review of the diagnostic accuracy of artificial intelligence-based computer programs to analyze chest x-rays for pulmonary tuberculosis. PLoS One. 2019; 14(9):e0221339. PMID: 31479448.
    Citations: 3     Fields:    Translation:Humans
  12. Nathavitharana RR. Stamping out Tuberculosis: The Importance of Diagnostic Innovation and Effective Implementation. Ann Am Thorac Soc. 2019 09; 16(9):1112-1113. PMID: 31145637.
    Citations:    Fields:    Translation:HumansCells
  13. van der Westhuizen HM, Nathavitharana RR, Pillay C, Schoeman I, Ehrlich R. The high-quality health system 'revolution': Re-imagining tuberculosis infection prevention and control. J Clin Tuberc Other Mycobact Dis. 2019 Dec; 17:100118. PMID: 31788560.
    Citations: 2     
  14. Olson G, Nathavitharana RR, Lederer PA. Diagnostic Delays and Treatment Implications for Patients with Isoniazid-Resistant Tuberculosis: A Case Report and Review of the Literature. Open Forum Infect Dis. 2019 Jun; 6(6):ofz222. PMID: 31211162.
  15. Nathavitharana RR, Strnad L, Lederer PA, Shah M, Hurtado RM. Top Questions in the Diagnosis and Treatment of Pulmonary M. abscessus Disease. Open Forum Infect Dis. 2019 Jul; 6(7):ofz221. PMID: 31289727.
    Citations: 2     
  16. Nathavitharana RR, Lederer P, Tierney DB, Nardell E. Treatment as prevention and other interventions to reduce transmission of multidrug-resistant tuberculosis. Int J Tuberc Lung Dis. 2019 04 01; 23(4):396-404. PMID: 31064617.
    Citations: 1     Fields:    Translation:Humans
  17. Subbaraman R, Nathavitharana RR, Mayer KH, Satyanarayana S, Chadha VK, Arinaminpathy N, Pai M. Constructing care cascades for active tuberculosis: A strategy for program monitoring and identifying gaps in quality of care. PLoS Med. 2019 02; 16(2):e1002754. PMID: 30811385.
    Citations: 12     Fields:    Translation:Humans
  18. Nathavitharana RR, Pai M. New strategies for inpatients with HIV and tuberculosis. Lancet. 2018 07 28; 392(10144):256-258. PMID: 30032976.
    Citations: 1     Fields:    Translation:HumansCells
  19. Derendinger B, de Vos M, Nathavitharana RR, Dolby T, Simpson JA, van Helden PD, Warren RM, Theron G. Widespread use of incorrect PCR ramp rate negatively impacts multidrug-resistant tuberculosis diagnosis (MTBDRplus). Sci Rep. 2018 02 16; 8(1):3206. PMID: 29453405.
    Citations: 1     Fields:    Translation:Humans
  20. Nathavitharana RR, Shi CX, Chindelevitch L, Calderon R, Zhang Z, Galea JT, Contreras C, Yataco R, Lecca L, Becerra MC, Murray MB, Cohen T. Polyclonal Pulmonary Tuberculosis Infections and Risk for Multidrug Resistance, Lima, Peru. Emerg Infect Dis. 2017 11; 23(11):1887-1890. PMID: 29048297.
    Citations: 1     Fields:    Translation:HumansCells
  21. Reuter A, Tisile P, von Delft D, Cox H, Cox V, Ditiu L, Garcia-Prats A, Koenig S, Lessem E, Nathavitharana R, Seddon JA, Stillo J, von Delft A, Furin J. The devil we know: is the use of injectable agents for the treatment of MDR-TB justified? Int J Tuberc Lung Dis. 2017 11 01; 21(11):1114-1126. PMID: 29037291.
    Citations: 9     Fields:    Translation:Humans
  22. Nathavitharana RR, Daru P, Barrera AE, Mostofa Kamal SM, Islam S, Ul-Alam M, Sultana R, Rahman M, Hossain MS, Lederer P, Hurwitz S, Chakraborty K, Kak N, Tierney DB, Nardell E. FAST implementation in Bangladesh: high frequency of unsuspected tuberculosis justifies challenges of scale-up. Int J Tuberc Lung Dis. 2017 09 01; 21(9):1020-1025. PMID: 28826452.
    Citations: 6     Fields:    Translation:HumansCells
  23. Lönnroth K, Mor Z, Erkens C, Bruchfeld J, Nathavitharana RR, van der Werf MJ, Lange C. Tuberculosis in migrants in low-incidence countries: epidemiology and intervention entry points. Int J Tuberc Lung Dis. 2017 06 01; 21(6):624-637. PMID: 28482956.
    Citations: 18     Fields:    Translation:HumansCellsPHPublic Health
  24. Bouffard MA, Nathavitharana RR, Yassa DS, Torun N. Re-Treatment With Ethambutol After Toxic Optic Neuropathy. J Neuroophthalmol. 2017 03; 37(1):40-42. PMID: 27636749.
    Citations:    Fields:    Translation:HumansCells
  25. Hargreaves S, Lönnroth K, Nellums LB, Olaru ID, Nathavitharana RR, Norredam M, Friedland JS. Response to Letter to the Editor by M. van der Werf, V. Hollo and C. Ködmön concerning 'Multidrug-resistant tuberculosis and migration to Europe'. Clin Microbiol Infect. 2017 08; 23(8):580. PMID: 28257900.
    Citations:    Fields:    Translation:HumansCells
  26. Nathavitharana RR, Bond P, Dramowski A, Kotze K, Lederer P, Oxley I, Peters JA, Rossouw C, van der Westhuizen HM, Willems B, Ting TX, von Delft A, von Delft D, Duarte R, Nardell E, Zumla A. Agents of change: The role of healthcare workers in the prevention of nosocomial and occupational tuberculosis. Presse Med. 2017 Mar; 46(2 Pt 2):e53-e62. PMID: 28256382.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  27. Nathavitharana RR, Cudahy PG, Schumacher SG, Steingart KR, Pai M, Denkinger CM. Accuracy of line probe assays for the diagnosis of pulmonary and multidrug-resistant tuberculosis: a systematic review and meta-analysis. Eur Respir J. 2017 01; 49(1). PMID: 28100546.
    Citations: 14     Fields:    Translation:HumansCells
  28. McGillen KL, Boos J, Nathavitharana R, Brook A, Sun MR, Siewert B, Raptopoulos V, Kane R, Sheiman R, Brook OR. Diagnostic yield and clinical impact of microbiologic diagnosis from CT-guided drainage in patients previously treated with empiric antibiotics. Abdom Radiol (NY). 2017 01; 42(1):298-305. PMID: 27654990.
    Citations:    Fields:    Translation:Humans
  29. Jenkins HE, Yuen CM, Rodriguez CA, Nathavitharana RR, McLaughlin MM, Donald P, Marais BJ, Becerra MC. Mortality in children diagnosed with tuberculosis: a systematic review and meta-analysis. Lancet Infect Dis. 2017 03; 17(3):285-295. PMID: 27964822.
    Citations: 28     Fields:    Translation:Humans
  30. Albert H, Nathavitharana RR, Denkinger CM, Isaacs C, Boehme CC. Tuberculosis prevention must integrate technological and basic care innovation. Eur Respir J. 2016 11; 48(5):1531-1532. PMID: 27799403.
    Citations: 1     Fields:    Translation:Humans
  31. Cazabon D, Alsdurf H, Satyanarayana S, Nathavitharana R, Subbaraman R, Daftary A, Pai M. Quality of tuberculosis care in high burden countries: the urgent need to address gaps in the care cascade. Int J Infect Dis. 2017 Mar; 56:111-116. PMID: 27794468.
    Citations: 41     Fields:    Translation:Humans
  32. Subbaraman R, Nathavitharana RR, Satyanarayana S, Pai M, Thomas BE, Chadha VK, Rade K, Swaminathan S, Mayer KH. The Tuberculosis Cascade of Care in India's Public Sector: A Systematic Review and Meta-analysis. PLoS Med. 2016 Oct; 13(10):e1002149. PMID: 27780217.
    Citations: 62     Fields:    Translation:Humans
  33. Hargreaves S, Lönnroth K, Nellums LB, Olaru ID, Nathavitharana RR, Norredam M, Friedland JS. Multidrug-resistant tuberculosis and migration to Europe. Clin Microbiol Infect. 2017 Mar; 23(3):141-146. PMID: 27665703.
    Citations: 10     Fields:    Translation:HumansPHPublic Health
  34. Nathavitharana RR, Peters J, Lederer P, von Delft A, Farley JE, Pai M, Jaramillo E, Raviglione M, Nardell E. Engaging health-care workers to reduce tuberculosis transmission. Lancet Infect Dis. 2016 08; 16(8):883-5. PMID: 27477968.
    Citations: 2     Fields:    Translation:Humans
  35. Albert H, Nathavitharana RR, Isaacs C, Pai M, Denkinger CM, Boehme CC. Development, roll-out and impact of Xpert MTB/RIF for tuberculosis: what lessons have we learnt and how can we do better? Eur Respir J. 2016 08; 48(2):516-25. PMID: 27418550.
    Citations: 56     Fields:    Translation:HumansCellsPHPublic Health
  36. Kunkel A, Abel Zur Wiesch P, Nathavitharana RR, Marx FM, Jenkins HE, Cohen T. Smear positivity in paediatric and adult tuberculosis: systematic review and meta-analysis. BMC Infect Dis. 2016 06 13; 16:282. PMID: 27296716.
    Citations: 12     Fields:    Translation:HumansCells
  37. Nathavitharana RR, Hillemann D, Schumacher SG, Schlueter B, Ismail N, Omar SV, Sikhondze W, Havumaki J, Valli E, Boehme C, Denkinger CM. Multicenter Noninferiority Evaluation of Hain GenoType MTBDRplus Version 2 and Nipro NTM+MDRTB Line Probe Assays for Detection of Rifampin and Isoniazid Resistance. J Clin Microbiol. 2016 06; 54(6):1624-1630. PMID: 27076658.
    Citations: 19     Fields:    Translation:HumansCells
  38. von Keudell A, Nathavitharana R, Yassa D, Abdeen A. An unusual pathogen for prosthetic joint infection. Lancet Infect Dis. 2016 Apr; 16(4):506. PMID: 27036357.
    Citations:    Fields:    Translation:Humans
  39. Nathavitharana RR, Friedland JS. A tale of two global emergencies: tuberculosis control efforts can learn from the Ebola outbreak. Eur Respir J. 2015 Aug; 46(2):293-6. PMID: 26232473.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  40. Nathavitharana RR, Fleischmann-Rose K, Yassa DS, Wertheimer MD, Alonso CD. An Unusual Cause of a Breast Mass in a Patient from China. Am J Trop Med Hyg. 2015 Aug; 93(2):347-9. PMID: 26033021.
    Citations:    Fields:    Translation:HumansAnimalsPHPublic Health
  41. Nathavitharana RR, Mitty JA. Diseases from North America: focus on tick-borne infections. Clin Med (Lond). 2015 Feb; 15(1):74-7. PMID: 25650204.
    Citations: 1     Fields:    Translation:Humans
  42. Taupin D, Mukherjee V, Nathavitharana R, Green DA, Fridman D. Lipiodol embolism following transarterial chemoembolization: an atypical case. Crit Care Med. 2014 Jun; 42(6):e481-4. PMID: 24607940.
    Citations: 2     Fields:    Translation:Humans
  43. Pai M, Nathavitharana R. Extrapulmonary tuberculosis: new diagnostics and new policies. Indian J Chest Dis Allied Sci. 2014 Apr-Jun; 56(2):71-3. PMID: 25230546.
    Citations: 4     Fields:    Translation:Humans
  44. Wright JD, NathavithArana R, Nathavithrana R, Lewin SN, Sun X, Deutsch I, Burke WM, Herzog TJ. Fertility-conserving surgery for young women with stage IA1 cervical cancer: safety and access. Obstet Gynecol. 2010 Mar; 115(3):585-90. PMID: 20177290.
    Citations: 14     Fields:    Translation:Humans
  45. Nathavitharana R, Coronel J, Moore DA. Solar disinfection of MODS mycobacterial cultures in resource-poor settings. PLoS One. 2007 Oct 31; 2(10):e1100. PMID: 17971863.
    Citations:    Fields:    Translation:CellsPHPublic Health
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.