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profileJoseph Gerard Sodroski, M.D.

TitleProfessor of Microbiology and Immunobiology
InstitutionDana-Farber Cancer Institute
DepartmentMicrobiology and Immunobiology
AddressDana-Farber Cancer Institute
C L S 1010
450 Brookline Ave
Boston MA 02215
Phone617/632-3371
Fax617/632-4338
vCardDownload vCard (login for email)
Other Positions
TitleProfessor in the Department of Immunology and Infectious Diseases
InstitutionHarvard T.H. Chan School of Public Health
DepartmentImmunology and Infectious Diseases


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R21AI129017     (SODROSKI, JOSEPH G)Feb 15, 2017 - Jan 31, 2019
NIH/NIAID
Reducing viral reservoirs by opening HIV-1 Env to antibody attack
Role: Principal Investigator

R01AI124982     (SODROSKI, JOSEPH G)Feb 15, 2016 - Jan 31, 2021
NIH/NIAID
Conformational Landscape of the HIV-1 Envelope Glycoproteins
Role: Principal Investigator

R03DA034601     (SODROSKI, JOSEPH G)May 1, 2012 - Apr 30, 2014
NIH/NIDA
Broad-range Inhibitors of Human Immunodeficiency Virus Entry
Role: Principal Investigator

R01AI093256     (SODROSKI, JOSEPH G)May 1, 2011 - Apr 30, 2016
NIH/NIAID
Single-particle Reconstruction of HIV-1 Envelope Glycoprotein Trimers
Role: Principal Investigator

R21AI076094     (SODROSKI, JOSEPH G)Jul 1, 2007 - Jun 30, 2009
NIH/NIAID
Structure of the Retroviral Restriction Factor, TRIM5alpha
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pancera M, Lai YT, Bylund T, Druz A, Narpala S, O'Dell S, Schön A, Bailer RT, Chuang GY, Geng H, Louder MK, Rawi R, Soumana DI, Finzi A, Herschhorn A, Madani N, Sodroski J, Freire E, Langley DR, Mascola JR, McDermott AB, Kwong PD. Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529. Nat Chem Biol. 2017 Aug 21. PMID: 28825711.
    View in: PubMed
  2. Johnson J, Zhai Y, Salimi H, Espy N, Eichelberger N, DeLeon O, O'Malley Y, Courter J, Smith AB, Madani N, Sodroski J, Haim H. Induction of a Tier-1-Like Phenotype in Diverse Tier-2 Isolates by Agents That Guide HIV-1 Env to Perturbation-Sensitive, Nonnative States. J Virol. 2017 Aug 01; 91(15). PMID: 28490588.
    View in: PubMed
  3. Herschhorn A, Sodroski J. An entry-competent intermediate state of the HIV-1 envelope glycoproteins. Receptors Clin Investig. 2017; 4(1). PMID: 28752105.
    View in: PubMed
  4. Espy N, Pacheco B, Sodroski J. Adaptation of HIV-1 to cells with low expression of the CCR5 coreceptor. Virology. 2017 Aug; 508:90-107. PMID: 28521215.
    View in: PubMed
  5. Richard J, Prévost J, von Bredow B, Ding S, Brassard N, Medjahed H, Coutu M, Melillo B, Bibollet-Ruche F, Hahn BH, Kaufmann DE, Smith AB, Sodroski J, Sauter D, Kirchhoff F, Gee K, Neil SJ, Evans DT, Finzi A. BST-2 Expression Modulates Small CD4-Mimetic Sensitization of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity. J Virol. 2017 Jun 01; 91(11). PMID: 28331088.
    View in: PubMed
  6. Go EP, Ding H, Zhang S, Ringe RP, Nicely N, Hua D, Steinbock RT, Golabek M, Alin J, Alam SM, Cupo A, Haynes BF, Kappes JC, Moore JP, Sodroski JG, Desaire H. Glycosylation Benchmark Profile for HIV-1 Envelope Glycoprotein Production Based on Eleven Env Trimers. J Virol. 2017 May 01; 91(9). PMID: 28202756.
    View in: PubMed
  7. Alam SM, Aussedat B, Vohra Y, Meyerhoff RR, Cale EM, Walkowicz WE, Radakovich NA, Anasti K, Armand L, Parks R, Sutherland L, Scearce R, Joyce MG, Pancera M, Druz A, Georgiev IS, Von Holle T, Eaton A, Fox C, Reed SG, Louder M, Bailer RT, Morris L, Abdool-Karim SS, Cohen M, Liao HX, Montefiori DC, Park PK, Fernández-Tejada A, Wiehe K, Santra S, Kepler TB, Saunders KO, Sodroski J, Kwong PD, Mascola JR, Bonsignori M, Moody MA, Danishefsky S, Haynes BF. Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide. Sci Transl Med. 2017 03 15; 9(381). PMID: 28298421.
    View in: PubMed
  8. Prévost J, Zoubchenok D, Richard J, Veillette M, Pacheco B, Coutu M, Brassard N, Parsons MS, Ruxrungtham K, Bunupuradah T, Tovanabutra S, Hwang KK, Moody MA, Haynes BF, Bonsignori M, Sodroski J, Kaufmann DE, Shaw GM, Chenine AL, Finzi A. Influence of the Envelope gp120 Phe 43 Cavity on HIV-1 Sensitivity to Antibody-Dependent Cell-Mediated Cytotoxicity Responses. J Virol. 2017 Apr 01; 91(7). PMID: 28100618.
    View in: PubMed
  9. Nguyen HT, Madani N, Ding H, Elder E, Princiotto A, Gu C, Darby P, Alin J, Herschhorn A, Kappes JC, Mao Y, Sodroski JG. Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV-1) envelope glycoprotein. Virol J. 2017 Feb 16; 14(1):33. PMID: 28209172.
    View in: PubMed
  10. Pacheco B, Alsahafi N, Debbeche O, Prévost J, Ding S, Chapleau JP, Herschhorn A, Madani N, Princiotto A, Melillo B, Gu C, Zeng X, Mao Y, Smith AB, Sodroski J, Finzi A. Residues in the gp41 Ectodomain Regulate HIV-1 Envelope Glycoprotein Conformational Transitions Induced by gp120-Directed Inhibitors. J Virol. 2017 Mar 01; 91(5). PMID: 28003492.
    View in: PubMed
  11. Witt KC, Castillo-Menendez L, Ding H, Espy N, Zhang S, Kappes JC, Sodroski J. Antigenic characterization of the human immunodeficiency virus (HIV-1) envelope glycoprotein precursor incorporated into nanodiscs. PLoS One. 2017; 12(2):e0170672. PMID: 28151945.
    View in: PubMed
  12. Madani N, Princiotto AM, Zhao C, Jahanbakhshsefidi F, Mertens M, Herschhorn A, Melillo B, Smith AB, Sodroski J. Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds. J Virol. 2017 Feb 01; 91(3). PMID: 27881646.
    View in: PubMed
  13. Ding S, Verly MM, Princiotto A, Melillo B, Moody AM, Bradley T, Easterhoff D, Roger M, Hahn BH, Madani N, Smith AB, Haynes BF, Sodroski J, Finzi A. Short Communication: Small-Molecule CD4 Mimetics Sensitize HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity by Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Nonhuman Primates. AIDS Res Hum Retroviruses. 2017 May; 33(5):428-431. PMID: 27846736.
    View in: PubMed
  14. Pacheco B, Menéndez-Arias L, Sodroski J. Characterization of two distinct early post-entry blocks to HIV-1 in common marmoset lymphocytes. Sci Rep. 2016 Nov 23; 6:37489. PMID: 27876849.
    View in: PubMed
  15. Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J. Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins. MBio. 2016 Oct 25; 7(5). PMID: 27795397.
    View in: PubMed
  16. Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M, Jia M, Brassard N, Park J, Courter JR, Melillo B, Martin L, Tremblay C, Hahn BH, Kaufmann DE, Wu X, Smith AB, Sodroski J, Pazgier M, Finzi A. Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins. EBioMedicine. 2016 Oct; 12:208-218. PMID: 27633463.
    View in: PubMed
  17. Bradley T, Trama A, Tumba N, Gray E, Lu X, Madani N, Jahanbakhsh F, Eaton A, Xia SM, Parks R, Lloyd KE, Sutherland LL, Scearce RM, Bowman CM, Barnett S, Abdool-Karim SS, Boyd SD, Melillo B, Smith AB, Sodroski J, Kepler TB, Alam SM, Gao F, Bonsignori M, Liao HX, Moody MA, Montefiori D, Santra S, Morris L, Haynes BF. Amino Acid Changes in the HIV-1 gp41 Membrane Proximal Region Control Virus Neutralization Sensitivity. EBioMedicine. 2016 Oct; 12:196-207. PMID: 27612593.
    View in: PubMed
  18. Li H, Wang S, Kong R, Ding W, Lee FH, Parker Z, Kim E, Learn GH, Hahn P, Policicchio B, Brocca-Cofano E, Deleage C, Hao X, Chuang GY, Gorman J, Gardner M, Lewis MG, Hatziioannou T, Santra S, Apetrei C, Pandrea I, Alam SM, Liao HX, Shen X, Tomaras GD, Farzan M, Chertova E, Keele BF, Estes JD, Lifson JD, Doms RW, Montefiori DC, Haynes BF, Sodroski JG, Kwong PD, Hahn BH, Shaw GM. Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques. Proc Natl Acad Sci U S A. 2016 06 14; 113(24):E3413-22. PMID: 27247400; PMCID: PMC4914158.
  19. Madani N, Princiotto AM, Easterhoff D, Bradley T, Luo K, Williams WB, Liao HX, Moody MA, Phad GE, Vázquez Bernat N, Melillo B, Santra S, Smith AB, Karlsson Hedestam GB, Haynes B, Sodroski J. Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Primates Neutralize Primary Human Immunodeficiency Viruses (HIV-1) Sensitized by CD4-Mimetic Compounds. J Virol. 2016 May 15; 90(10):5031-46. PMID: 26962221; PMCID: PMC4859707 [Available on 10/29/16].
  20. Haynes BF, Shaw GM, Korber B, Kelsoe G, Sodroski J, Hahn BH, Borrow P, McMichael AJ. HIV-Host Interactions: Implications for Vaccine Design. Cell Host Microbe. 2016 Mar 09; 19(3):292-303. PMID: 26922989; PMCID: PMC4823811.
  21. Melillo B, Liang S, Park J, Schön A, Courter JR, LaLonde JM, Wendler DJ, Princiotto AM, Seaman MS, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith AB. Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition. ACS Med Chem Lett. 2016 Mar 10; 7(3):330-4. PMID: 26985324; PMCID: PMC4789667 [Available on 03/10/17].
  22. Lee WS, Richard J, Lichtfuss M, Smith AB, Park J, Courter JR, Melillo BN, Sodroski JG, Kaufmann DE, Finzi A, Parsons MS, Kent SJ. Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells. J Virol. 2015 Dec 09; 90(4):2021-30. PMID: 26656700; PMCID: PMC4733999.
  23. Richard J, Veillette M, Ding S, Zoubchenok D, Alsahafi N, Coutu M, Brassard N, Park J, Courter JR, Melillo B, Smith AB, Shaw GM, Hahn BH, Sodroski J, Kaufmann DE, Finzi A. Small CD4 Mimetics Prevent HIV-1 Uninfected Bystander CD4 + T Cell Killing Mediated by Antibody-dependent Cell-mediated Cytotoxicity. EBioMedicine. 2016 Jan; 3:122-34. PMID: 26870823; PMCID: PMC4739418.
  24. Fernández-Oliva A, Finzi A, Haim H, Menéndez-Arias L, Sodroski J, Pacheco B. HIV-1 Adapts To Replicate in Cells Expressing Common Marmoset APOBEC3G and BST2. J Virol. 2015 Oct 28; 90(2):725-40. PMID: 26512082; PMCID: PMC4702673.
  25. Moody MA, Gao F, Gurley TC, Amos JD, Kumar A, Hora B, Marshall DJ, Whitesides JF, Xia SM, Parks R, Lloyd KE, Hwang KK, Lu X, Bonsignori M, Finzi A, Vandergrift NA, Alam SM, Ferrari G, Shen X, Tomaras GD, Kamanga G, Cohen MS, Sam NE, Kapiga S, Gray ES, Tumba NL, Morris L, Zolla-Pazner S, Gorny MK, Mascola JR, Hahn BH, Shaw GM, Sodroski JG, Liao HX, Montefiori DC, Hraber PT, Korber BT, Haynes BF. Strain-Specific V3 and CD4 Binding Site Autologous HIV-1 Neutralizing Antibodies Select Neutralization-Resistant Viruses. Cell Host Microbe. 2015 Sep 09; 18(3):354-62. PMID: 26355218; PMCID: PMC4567706.
  26. Go EP, Herschhorn A, Gu C, Castillo-Menendez L, Zhang S, Mao Y, Chen H, Ding H, Wakefield JK, Hua D, Liao HX, Kappes JC, Sodroski J, Desaire H. Comparative Analysis of the Glycosylation Profiles of Membrane-Anchored HIV-1 Envelope Glycoprotein Trimers and Soluble gp140. J Virol. 2015 Aug; 89(16):8245-57. PMID: 26018173; PMCID: PMC4524223.
  27. Richard J, Veillette M, Brassard N, Iyer SS, Roger M, Martin L, Pazgier M, Schön A, Freire E, Routy JP, Smith AB, Park J, Jones DM, Courter JR, Melillo BN, Kaufmann DE, Hahn BH, Permar SR, Haynes BF, Madani N, Sodroski JG, Finzi A. CD4 mimetics sensitize HIV-1-infected cells to ADCC. Proc Natl Acad Sci U S A. 2015 May 19; 112(20):E2687-94. PMID: 25941367; PMCID: PMC4443331.
  28. Alsahafi N, Debbeche O, Sodroski J, Finzi A. Effects of the I559P gp41 change on the conformation and function of the human immunodeficiency virus (HIV-1) membrane envelope glycoprotein trimer. PLoS One. 2015; 10(4):e0122111. PMID: 25849367; PMCID: PMC4388519.
  29. Zhang S, Sodroski J. Efficient human immunodeficiency virus (HIV-1) infection of cells lacking PDZD8. Virology. 2015 Jul; 481:73-8. PMID: 25771112; PMCID: PMC4437853.
  30. Asmal M, Luedemann C, Lavine CL, Mach LV, Balachandran H, Brinkley C, Denny TN, Lewis MG, Anderson H, Pal R, Sok D, Le K, Pauthner M, Hahn BH, Shaw GM, Seaman MS, Letvin NL, Burton DR, Sodroski JG, Haynes BF, Santra S. Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes. Virology. 2015 Jan 15; 475:37-45. PMID: 25462344; PMCID: PMC4280322 [Available on 01/15/16].
  31. Pancera M, Druz A, Zhou T, O'Dell S, Louder M, Madani N, Herschhorn A, Sodroski J, Mascola JR, Kwong PD. Structure of BMS-806, a Small-molecule HIV-1 Entry Inhibitor, Bound to BG505 SOSIP.664 HIV-1 Env Trimer. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A151. PMID: 25357424.
    View in: PubMed
  32. Herschhorn A, Gu C, Espy N, Richard J, Finzi A, Sodroski JG. A broad HIV-1 inhibitor blocks envelope glycoprotein transitions critical for entry. Nat Chem Biol. 2014 Oct; 10(10):845-52. PMID: 25174000; PMCID: PMC4231716.
  33. Tipper C, Sodroski JG. Contribution of glutamine residues in the helix 4-5 loop to capsid-capsid interactions in simian immunodeficiency virus of macaques. J Virol. 2014 Sep; 88(18):10289-302. PMID: 24991000; PMCID: PMC4178892.
  34. Madani N, Princiotto AM, Schön A, LaLonde J, Feng Y, Freire E, Park J, Courter JR, Jones DM, Robinson J, Liao HX, Moody MA, Permar S, Haynes B, Smith AB, Wyatt R, Sodroski J. CD4-mimetic small molecules sensitize human immunodeficiency virus to vaccine-elicited antibodies. J Virol. 2014 Jun; 88(12):6542-55. PMID: 24696475; PMCID: PMC4054336.
  35. Yen PJ, Herschhorn A, Haim H, Salas I, Gu C, Sodroski J, Gabuzda D. Loss of a conserved N-linked glycosylation site in the simian immunodeficiency virus envelope glycoprotein V2 region enhances macrophage tropism by increasing CD4-independent cell-to-cell transmission. J Virol. 2014 May; 88(9):5014-28. PMID: 24554659; PMCID: PMC3993815.
  36. Guth CA, Sodroski J. Contribution of PDZD8 to stabilization of the human immunodeficiency virus type 1 capsid. J Virol. 2014 May; 88(9):4612-23. PMID: 24554657; PMCID: PMC3993830.
  37. Courter JR, Madani N, Sodroski J, Schön A, Freire E, Kwong PD, Hendrickson WA, Chaiken IM, LaLonde JM, Smith AB. Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist. Acc Chem Res. 2014 Apr 15; 47(4):1228-37. PMID: 24502450; PMCID: PMC3993944.
  38. Veillette M, Désormeaux A, Medjahed H, Gharsallah NE, Coutu M, Baalwa J, Guan Y, Lewis G, Ferrari G, Hahn BH, Haynes BF, Robinson JE, Kaufmann DE, Bonsignori M, Sodroski J, Finzi A. Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity. J Virol. 2014 Mar; 88(5):2633-44. PMID: 24352444; PMCID: PMC3958102.
  39. Haim H, Salas I, McGee K, Eichelberger N, Winter E, Pacheco B, Sodroski J. Modeling virus- and antibody-specific factors to predict human immunodeficiency virus neutralization efficiency. Cell Host Microbe. 2013 Nov 13; 14(5):547-58. PMID: 24237700; PMCID: PMC3875163.
  40. Mao Y, Castillo-Menendez LR, Sodroski JG. Reply to Subramaniam, van Heel, and Henderson: Validity of the cryo-electron microscopy structures of the HIV-1 envelope glycoprotein complex. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):E4178-82. PMID: 24350339; PMCID: PMC3831492.
  41. Alam SM, Dennison SM, Aussedat B, Vohra Y, Park PK, Fernández-Tejada A, Stewart S, Jaeger FH, Anasti K, Blinn JH, Kepler TB, Bonsignori M, Liao HX, Sodroski JG, Danishefsky SJ, Haynes BF. Recognition of synthetic glycopeptides by HIV-1 broadly neutralizing antibodies and their unmutated ancestors. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18214-9. PMID: 24145434; PMCID: PMC3831483.
  42. McGee K, Haim H, Korioth-Schmitz B, Espy N, Javanbakht H, Letvin N, Sodroski J. The selection of low envelope glycoprotein reactivity to soluble CD4 and cold during simian-human immunodeficiency virus infection of rhesus macaques. J Virol. 2014 Jan; 88(1):21-40. PMID: 24131720; PMCID: PMC3911730.
  43. Aussedat B, Vohra Y, Park PK, Fernández-Tejada A, Alam SM, Dennison SM, Jaeger FH, Anasti K, Stewart S, Blinn JH, Liao HX, Sodroski JG, Haynes BF, Danishefsky SJ. Chemical synthesis of highly congested gp120 V1V2 N-glycopeptide antigens for potential HIV-1-directed vaccines. J Am Chem Soc. 2013 Sep 04; 135(35):13113-20. PMID: 23915436; PMCID: PMC3826081.
  44. Bohl C, Bowder D, Thompson J, Abrahamyan L, Gonzalez-Ramirez S, Mao Y, Sodroski J, Wood C, Xiang SH. A twin-cysteine motif in the V2 region of gp120 is associated with SIV envelope trimer stabilization. PLoS One. 2013; 8(7):e69406. PMID: 23936006; PMCID: PMC3720275.
  45. Mao Y, Wang L, Gu C, Herschhorn A, Désormeaux A, Finzi A, Xiang SH, Sodroski JG. Molecular architecture of the uncleaved HIV-1 envelope glycoprotein trimer. Proc Natl Acad Sci U S A. 2013 Jul 23; 110(30):12438-43. PMID: 23757493; PMCID: PMC3725050.
  46. Li X, Kim J, Song B, Finzi A, Pacheco B, Sodroski J. Virus-specific effects of TRIM5a(rh) RING domain functions on restriction of retroviruses. J Virol. 2013 Jul; 87(13):7234-45. PMID: 23637418; PMCID: PMC3700309.
  47. Lalonde JM, Le-Khac M, Jones DM, Courter JR, Park J, Schön A, Princiotto AM, Wu X, Mascola JR, Freire E, Sodroski J, Madani N, Hendrickson WA, Smith AB. Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization. ACS Med Chem Lett. 2013 Mar 14; 4(3):338-343. PMID: 23667716.
    View in: PubMed
  48. Xiang SH, Pacheco B, Bowder D, Yuan W, Sodroski J. Characterization of a dual-tropic human immunodeficiency virus (HIV-1) strain derived from the prototypical X4 isolate HXBc2. Virology. 2013 Mar 30; 438(1):5-13. PMID: 23369572; PMCID: PMC3594413.
  49. Tipper C, Sodroski J. Enhanced autointegration in hyperstable simian immunodeficiency virus capsid mutants blocked after reverse transcription. J Virol. 2013 Apr; 87(7):3628-39. PMID: 23345510; PMCID: PMC3624228.
  50. Medjahed H, Pacheco B, Désormeaux A, Sodroski J, Finzi A. The HIV-1 gp120 major variable regions modulate cold inactivation. J Virol. 2013 Apr; 87(7):4103-11. PMID: 23345516; PMCID: PMC3624226.
  51. Désormeaux A, Coutu M, Medjahed H, Pacheco B, Herschhorn A, Gu C, Xiang SH, Mao Y, Sodroski J, Finzi A. The highly conserved layer-3 component of the HIV-1 gp120 inner domain is critical for CD4-required conformational transitions. J Virol. 2013 Mar; 87(5):2549-62. PMID: 23255784; PMCID: PMC3571356.
  52. Zhuang K, Finzi A, Toma J, Frantzell A, Huang W, Sodroski J, Cheng-Mayer C. Identification of interdependent variables that influence coreceptor switch in R5 SHIV(SF162P3N)-infected macaques. Retrovirology. 2012 Dec 13; 9:106. PMID: 23237529; PMCID: PMC3528637.
  53. Haim H, Salas I, Sodroski J. Proteolytic processing of the human immunodeficiency virus envelope glycoprotein precursor decreases conformational flexibility. J Virol. 2013 Feb; 87(3):1884-9. PMID: 23175369; PMCID: PMC3554131.
  54. Tuzer F, Madani N, Kamanna K, Zentner I, LaLonde J, Holmes A, Upton E, Rajagopal S, McFadden K, Contarino M, Sodroski J, Chaiken I. HIV-1 Env gp120 structural determinants for peptide triazole dual receptor site antagonism. Proteins. 2013 Feb; 81(2):271-90. PMID: 23011758; PMCID: PMC3731144.
  55. Choi WT, Kumar S, Madani N, Han X, Tian S, Dong CZ, Liu D, Duggineni S, Yuan J, Sodroski JG, Huang Z, An J. A novel synthetic bivalent ligand to probe chemokine receptor CXCR4 dimerization and inhibit HIV-1 entry. Biochemistry. 2012 Sep 11; 51(36):7078-86. PMID: 22897429; PMCID: PMC3476724.
  56. Mao Y, Wang L, Gu C, Herschhorn A, Xiang SH, Haim H, Yang X, Sodroski J. Subunit organization of the membrane-bound HIV-1 envelope glycoprotein trimer. Nat Struct Mol Biol. 2012 Sep; 19(9):893-9. PMID: 22864288; PMCID: PMC3443289.
  57. Finzi A, Pacheco B, Xiang SH, Pancera M, Herschhorn A, Wang L, Zeng X, Desormeaux A, Kwong PD, Sodroski J. Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding. J Virol. 2012 Sep; 86(17):8974-86. PMID: 22696649; PMCID: PMC3416166.
  58. Kortagere S, Madani N, Mankowski MK, Schön A, Zentner I, Swaminathan G, Princiotto A, Anthony K, Oza A, Sierra LJ, Passic SR, Wang X, Jones DM, Stavale E, Krebs FC, Martín-García J, Freire E, Ptak RG, Sodroski J, Cocklin S, Smith AB. Inhibiting early-stage events in HIV-1 replication by small-molecule targeting of the HIV-1 capsid. J Virol. 2012 Aug; 86(16):8472-81. PMID: 22647699; PMCID: PMC3421734.
  59. LaLonde JM, Kwon YD, Jones DM, Sun AW, Courter JR, Soeta T, Kobayashi T, Princiotto AM, Wu X, Schön A, Freire E, Kwong PD, Mascola JR, Sodroski J, Madani N, Smith AB. Structure-based design, synthesis, and characterization of dual hotspot small-molecule HIV-1 entry inhibitors. J Med Chem. 2012 May 10; 55(9):4382-96. PMID: 22497421; PMCID: PMC3376652.
  60. Kwon YD, Finzi A, Wu X, Dogo-Isonagie C, Lee LK, Moore LR, Schmidt SD, Stuckey J, Yang Y, Zhou T, Zhu J, Vicic DA, Debnath AK, Shapiro L, Bewley CA, Mascola JR, Sodroski JG, Kwong PD. Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops. Proc Natl Acad Sci U S A. 2012 Apr 10; 109(15):5663-8. PMID: 22451932; PMCID: PMC3326499.
  61. Lavine CL, Lao S, Montefiori DC, Haynes BF, Sodroski JG, Yang X. High-mannose glycan-dependent epitopes are frequently targeted in broad neutralizing antibody responses during human immunodeficiency virus type 1 infection. J Virol. 2012 Feb; 86(4):2153-64. PMID: 22156525; PMCID: PMC3302386.
  62. Dong CZ, Tian S, Madani N, Choi WT, Kumar S, Liu D, Sodroski JG, Huang Z, An J. Role of CXCR4 internalization in the anti-HIV activity of stromal cell-derived factor-1a probed by a novel synthetically and modularly modified-chemokine analog. Exp Biol Med (Maywood). 2011 Dec; 236(12):1413-9. PMID: 22101518; PMCID: PMC3752462.
  63. Herschhorn A, Finzi A, Jones DM, Courter JR, Sugawara A, Smith AB, Sodroski JG. An inducible cell-cell fusion system with integrated ability to measure the efficiency and specificity of HIV-1 entry inhibitors. PLoS One. 2011; 6(11):e26731. PMID: 22069466; PMCID: PMC3206054.
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  407. Walker BD, Kowalski M, Goh WC, Kozarsky K, Krieger M, Rosen C, Rohrschneider L, Haseltine WA, Sodroski J. Inhibition of human immunodeficiency virus syncytium formation and virus replication by castanospermine. Proc Natl Acad Sci U S A. 1987 Nov; 84(22):8120-4. PMID: 2825177; PMCID: PMC299490.
  408. Mosca JD, Bednarik DP, Raj NB, Rosen CA, Sodroski JG, Haseltine WA, Hayward GS, Pitha PM. Activation of human immunodeficiency virus by herpesvirus infection: identification of a region within the long terminal repeat that responds to a trans-acting factor encoded by herpes simplex virus 1. Proc Natl Acad Sci U S A. 1987 Nov; 84(21):7408-12. PMID: 2823260; PMCID: PMC299305.
  409. Kowalski M, Potz J, Basiripour L, Dorfman T, Goh WC, Terwilliger E, Dayton A, Rosen C, Haseltine W, Sodroski J. Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1. Science. 1987 Sep 11; 237(4820):1351-5. PMID: 3629244.
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  410. Rosen CA, Park R, Sodroski JG, Haseltine WA. Multiple sequence elements are required for regulation of human T-cell leukemia virus gene expression. Proc Natl Acad Sci U S A. 1987 Jul; 84(14):4919-23. PMID: 3037527; PMCID: PMC305218.
  411. Sodroski J, Kowalski M, Dorfman T, Basiripour L, Rosen C, Haseltine W. HIV envelope-CD4 interaction not inhibited by synthetic octapeptides. Lancet. 1987 Jun 20; 1(8547):1428-9. PMID: 2884513.
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  412. Greene WC, Leonard WJ, Wano Y, Svetlik PB, Peffer NJ, Sodroski JG, Rosen CA, Goh WC, Haseltine WA. Trans-activator gene of HTLV-II: interpretation. Science. 1987 Feb 27; 235(4792):1073. PMID: 3029865.
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  413. Goh WC, Sodroski JG, Rosen CA, Haseltine WA. Expression of the art gene protein of human T-lymphotropic virus type III (HTLV-III/LAV) in bacteria. J Virol. 1987 Feb; 61(2):633-7. PMID: 3543401; PMCID: PMC253996.
  414. Patarca R, Heath C, Goldenberg GJ, Rosen CA, Sodroski JG, Haseltine WA, Hansen UM. Transcription directed by the HIV long terminal repeat in vitro. AIDS Res Hum Retroviruses. 1987; 3(1):41-55. PMID: 3040054.
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  415. Haseltine W, Sodroski J, Rosen C. Replication and pathogenesis of the human T-cell leukemia/lymphotropic retroviruses. Haematol Blood Transfus. 1987; 31:395-403. PMID: 2895046.
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  416. Mosca JD, Bednarik DP, Raj NB, Rosen CA, Sodroski JG, Haseltine WA, Pitha PM. Herpes simplex virus type-1 can reactivate transcription of latent human immunodeficiency virus. Nature. 1987 Jan 1-7; 325(6099):67-70. PMID: 3025748.
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  417. Ratner L, Sodroski JG, Wong-Staal F, Haseltine WA, Shaw GM, Gallo RC. Mechanism of leukemogenesis by human T-cell leukemia virus types I and II: role of the lor gene. Cancer Detect Prev. 1987; 10(5-6):411-24. PMID: 2882850.
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  418. Terwilliger E, Sodroski JG, Rosen CA, Haseltine WA. Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity. J Virol. 1986 Nov; 60(2):754-60. PMID: 3490583; PMCID: PMC288951.
  419. Rosen CA, Sodroski JG, Willems L, Kettmann R, Campbell K, Zaya R, Burny A, Haseltine WA. The 3' region of bovine leukemia virus genome encodes a trans-activator protein. EMBO J. 1986 Oct; 5(10):2585-9. PMID: 3023049; PMCID: PMC1167156.
  420. Tanese N, Sodroski J, Haseltine WA, Goff SP. Expression of reverse transcriptase activity of human T-lymphotropic virus type III (HTLV-III/LAV) in Escherichia coli. J Virol. 1986 Sep; 59(3):743-5. PMID: 2426471; PMCID: PMC253253.
  421. Goh WC, Rosen C, Sodroski J, Ho DD, Haseltine WA. Identification of a protein encoded by the trans activator gene tatIII of human T-cell lymphotropic retrovirus type III. J Virol. 1986 Jul; 59(1):181-4. PMID: 2423703; PMCID: PMC253056.
  422. Sodroski J, Goh WC, Rosen C, Campbell K, Haseltine WA. Role of the HTLV-III/LAV envelope in syncytium formation and cytopathicity. Nature. 1986 Jul 31-Aug 6; 322(6078):470-4. PMID: 3016552.
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  423. Greene WC, Leonard WJ, Wano Y, Svetlik PB, Peffer NJ, Sodroski JG, Rosen CA, Goh WC, Haseltine WA. Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression. Science. 1986 May 16; 232(4752):877-80. PMID: 3010456.
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  424. Sodroski J, Goh WC, Rosen C, Dayton A, Terwilliger E, Haseltine W. A second post-transcriptional trans-activator gene required for HTLV-III replication. Nature. 1986 May 22-28; 321(6068):412-7. PMID: 3012355.
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  425. Sodroski J, Goh WC, Rosen C, Tartar A, Portetelle D, Burny A, Haseltine W. Replicative and cytopathic potential of HTLV-III/LAV with sor gene deletions. Science. 1986 Mar 28; 231(4745):1549-53. PMID: 3006244.
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  426. Dayton AI, Sodroski JG, Rosen CA, Goh WC, Haseltine WA. The trans-activator gene of the human T cell lymphotropic virus type III is required for replication. Cell. 1986 Mar 28; 44(6):941-7. PMID: 2420471.
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  427. Rosen CA, Sodroski JG, Kettman R, Haseltine WA. Activation of enhancer sequences in type II human T-cell leukemia virus and bovine leukemia virus long terminal repeats by virus-associated trans-acting regulatory factors. J Virol. 1986 Mar; 57(3):738-44. PMID: 3005624; PMCID: PMC252800.
  428. Rosen CA, Sodroski JG, Goh WC, Dayton AI, Lippke J, Haseltine WA. Post-transcriptional regulation accounts for the trans-activation of the human T-lymphotropic virus type III. Nature. 1986 Feb 13-19; 319(6054):555-9. PMID: 3003584.
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  429. Haseltine WA, Sodroski J, Rosen CA. Control of gene expression and the replication and pathogenesis of retroviruses. Important Adv Oncol. 1986; 159-72. PMID: 3330531.
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  430. Rosen CA, Sodroski JG, Campbell K, Haseltine WA. Construction of recombinant murine retroviruses that express the human T-cell leukemia virus type II and human T-cell lymphotropic virus type III trans activator genes. J Virol. 1986 Jan; 57(1):379-84. PMID: 3001360; PMCID: PMC252741.
  431. Rosen CA, Sodroski JG, Haseltine WA. Location of cis-acting regulatory sequences in the human T-cell leukemia virus type I long terminal repeat. Proc Natl Acad Sci U S A. 1985 Oct; 82(19):6502-6. PMID: 2995968; PMCID: PMC390745.
  432. Haseltine WA, Sodroski J, Rosen C. The lor gene and pathogenesis of HTLV-I, -II, and -III. Cancer Res. 1985 Sep; 45(9 Suppl):4545s-4549s. PMID: 2990684.
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  433. Sodroski JG, Goh WC, Rosen CA, Salahuddin SZ, Aldovini A, Franchini G, Wong-Staal F, Gallo RC, Sugamura K, Hinuma Y, et al. trans-Activation of the human T-cell leukemia virus long terminal repeat correlates with expression of the x-lor protein. J Virol. 1985 Sep; 55(3):831-5. PMID: 2991599; PMCID: PMC255069.
  434. Goh WC, Sodroski J, Rosen C, Haseltine W. Expression of the x-lor gene of human T-cell leukemia virus I in Escherichia coli. J Virol. 1985 Aug; 55(2):497-9. PMID: 2991573; PMCID: PMC254960.
  435. Sodroski J, Patarca R, Rosen C, Wong-Staal F, Haseltine W. Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III. Science. 1985 Jul 05; 229(4708):74-7. PMID: 2990041.
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  436. Rosen CA, Sodroski JG, Haseltine WA. The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat. Cell. 1985 Jul; 41(3):813-23. PMID: 2988790.
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  437. Sodroski J, Rosen C, Goh WC, Haseltine W. A transcriptional activator protein encoded by the x-lor region of the human T-cell leukemia virus. Science. 1985 Jun 21; 228(4706):1430-4. PMID: 2990028.
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  438. Allan JS, Coligan JE, Barin F, McLane MF, Sodroski JG, Rosen CA, Haseltine WA, Lee TH, Essex M. Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III. Science. 1985 May 31; 228(4703):1091-4. PMID: 2986290.
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  439. Goh WC, Sodroski J, Rosen C, Essex M, Haseltine WA. Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I. Science. 1985 Mar 08; 227(4691):1227-8. PMID: 2983419.
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  440. Rosen CA, Sodroski JG, Kettman R, Burny A, Haseltine WA. Trans activation of the bovine leukemia virus long terminal repeat in BLV-infected cells. Science. 1985 Jan 18; 227(4684):320-2. PMID: 2981432.
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  441. Sodroski J, Rosen C, Wong-Staal F, Salahuddin SZ, Popovic M, Arya S, Gallo RC, Haseltine WA. Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeat. Science. 1985 Jan 11; 227(4683):171-3. PMID: 2981427.
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  442. Haseltine WA, Sodroski JG, Patarca R. Structure and function of the genome of HTLV. Curr Top Microbiol Immunol. 1985; 115:177-209. PMID: 2579773.
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  443. Lee TH, Coligan JE, McLane MF, Sodroski JG, Popovic M, Wong-Staal F, Gallo RC, Haseltine W, Essex M. Serological cross-reactivity between envelope gene products of type I and type II human T-cell leukemia virus. Proc Natl Acad Sci U S A. 1984 Dec; 81(23):7579-83. PMID: 6095307; PMCID: PMC392190.
  444. Josephs SF, Wong-Staal F, Manzari V, Gallo RC, Sodroski JG, Trus MD, Perkins D, Patarca R, Haseltine WA. Long terminal repeat structure of an American isolate of type I human T-cell leukemia virus. Virology. 1984 Dec; 139(2):340-5. PMID: 6097028.
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  445. Lee TH, Coligan JE, Sodroski JG, Haseltine WA, Salahuddin SZ, Wong-Staal F, Gallo RC, Essex M. Antigens encoded by the 3'-terminal region of human T-cell leukemia virus: evidence for a functional gene. Science. 1984 Oct 05; 226(4670):57-61. PMID: 6089350.
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  446. Sodroski J, Trus M, Perkins D, Patarca R, Wong-Staal F, Gelmann E, Gallo R, Haseltine WA. Repetitive structure in the long-terminal-repeat element of a type II human T-cell leukemia virus. Proc Natl Acad Sci U S A. 1984 Aug; 81(15):4617-21. PMID: 6087335; PMCID: PMC391541.
  447. Sodroski J, Patarca R, Perkins D, Briggs D, Lee TH, Essex M, Coligan J, Wong-Staal F, Gallo RC, Haseltine WA. Sequence of the envelope glycoprotein gene of type II human T lymphotropic virus. Science. 1984 Jul 27; 225(4660):421-4. PMID: 6204380.
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  448. Haseltine WA, Sodroski J, Patarca R, Briggs D, Perkins D, Wong-Staal F. Structure of 3' terminal region of type II human T lymphotropic virus: evidence for new coding region. Science. 1984 Jul 27; 225(4660):419-21. PMID: 6330894.
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  449. Sodroski JG, Rosen CA, Haseltine WA. Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells. Science. 1984 Jul 27; 225(4660):381-5. PMID: 6330891.
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  450. Sodroski JG, Goh WC, Haseltine WA. Transforming potential of a human protooncogene (c-fps/fes) locus. Proc Natl Acad Sci U S A. 1984 May; 81(10):3039-43. PMID: 6328490; PMCID: PMC345216.
  451. Haseltine WA, Sodroski J, Rosen C. Structure and function of human leukemia and AIDS viruses. Princess Takamatsu Symp. 1984; 15:187-96. PMID: 6100638.
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  452. Horn TM, Sodroski J, Qasba PK. Protein-coding capacities of polyadenylated RNAs from normal and neoplastic rat mammary tissues. Cancer Res. 1983 Apr; 43(4):1819-26. PMID: 6187440.
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  453. Sodroski JG, Lenz JR, Haseltine WA. Reflections and speculations regarding mechanisms of carcinogenesis. INSERM. 1983; 189-216.
  454. Sodroski JG, Patarca R, Lenz J, Trus M, Crowther R, Perkins D, Gallo R, Wong-Staal F, Josephs S, Gelman E, Haseltine WA. LTR regions of murine leukemia virus and human T cell leukemia virus as potential leukemogenic and pathogenic determinants. Human T cell Leukemia/Lymphoma Virus - Cold Spring Harbor Labs. 1983; 149-155.
  455. Trus MD, Sodroski JG, Haseltine WA. Isolation and characterization of a human locus homologous to the transforming gene (v-fes) of feline sarcoma virus. J Biol Chem. 1982 Mar 25; 257(6):2730-3. PMID: 6277911.
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