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Marc Lipsitch, D.Phil.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U54GM088558 (LIPSITCH, MARC) Sep 15, 2009 - Aug 31, 2019
    NIH/NIGMS
    MIDAS Center for Communicable Disease Dynamics
    Role: Principal Investigator
  2. U01GM076497 (LIPSITCH, MARC) Feb 1, 2006 - Sep 14, 2009
    NIH/NIGMS
    Methodological Approaches to Planning and Analysis of N*
    Role: Principal Investigator
  3. R21AI055825 (LIPSITCH, MARC) Apr 15, 2003 - Mar 31, 2006
    NIH/NIAID
    Epidemiologic Methods: Resistant Nosocomial Infections
    Role: Principal Investigator
  4. R01AI048935 (LIPSITCH, MARC) Feb 1, 2001 - Sep 25, 2012
    NIH/NIAID
    Mechanisms and Population Genomics of Pneumococcal Antigenic Diversity
    Role: Principal Investigator
  5. F32GM019182 (LIPSITCH, MARC) Dec 19, 1997
    NIH/NIGMS
    POPULATION DYNAMICS OF BACTERIAL INFECTION AND TREATMENT
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ray GT, Lewis N, Klein NP, Daley MF, Lipsitch M, Fireman B. Depletion-of-susceptibles Bias in Analyses of Intra-season Waning of Influenza Vaccine Effectiveness. Clin Infect Dis. 2020 Mar 17; 70(7):1484-1486. PMID: 31351439.
    Citations:    
  2. MacFadden DR, Coburn B, Brinda K, Corbeil A, Daneman N, Fisman D, Lee RS, Lipsitch M, McGeer A, Melano RG, Mubareka S, Hanage WP. Using Genetic Distance from Archived Samples for the Prediction of Antibiotic Resistance in Escherichia coli. Antimicrob Agents Chemother. 2020 Mar 09. PMID: 32152083.
    Citations:    
  3. Goldstein E, Lipsitch M. The relation between prescribing of different antibiotics and rates of mortality with sepsis in US adults. BMC Infect Dis. 2020 Feb 22; 20(1):169. PMID: 32087679.
    Citations:    
  4. Lipsitch M, Swerdlow DL, Finelli L. Defining the Epidemiology of Covid-19 - Studies Needed. N Engl J Med. 2020 Feb 19. PMID: 32074416.
    Citations:    
  5. Tedijanto C, Grad YH, Lipsitch M. Potential impact of outpatient stewardship interventions on antibiotic exposures of common bacterial pathogens. Elife. 2020 Feb 05; 9. PMID: 32022685.
    Citations:    
  6. Inglesby TV, Lipsitch M. Proposed Changes to U.S. Policy on Potential Pandemic Pathogen Oversight and Implementation. mSphere. 2020 01 22; 5(1). PMID: 31969482.
    Citations:    
  7. Chua H, Feng S, Lewnard JA, Sullivan SG, Blyth CC, Lipsitch M, Cowling BJ. The Use of Test-negative Controls to Monitor Vaccine Effectiveness: A Systematic Review of Methodology. Epidemiology. 2020 Jan; 31(1):43-64. PMID: 31609860.
    Citations:    
  8. Kennedy-Shaffer L, de Gruttola V, Lipsitch M. Novel methods for the analysis of stepped wedge cluster randomized trials. Stat Med. 2020 Mar 30; 39(7):815-844. PMID: 31876979.
    Citations:    
  9. Knight GM, Davies NG, Colijn C, Coll F, Donker T, Gifford DR, Glover RE, Jit M, Klemm E, Lehtinen S, Lindsay JA, Lipsitch M, Llewelyn MJ, Mateus ALP, Robotham JV, Sharland M, Stekel D, Yakob L, Atkins KE. Mathematical modelling for antibiotic resistance control policy: do we know enough? BMC Infect Dis. 2019 Nov 29; 19(1):1011. PMID: 31783803.
    Citations:    
  10. Lipsitch M, Goldstein E, Ray GT, Fireman B. Depletion-of-susceptibles bias in influenza vaccine waning studies: how to ensure robust results. Epidemiol Infect. 2019 11 27; 147:e306. PMID: 31774051.
    Citations:    
  11. Hicks AL, Kissler SM, Lipsitch M, Grad YH. Surveillance to maintain the sensitivity of genotype-based antibiotic resistance diagnostics. PLoS Biol. 2019 11; 17(11):e3000547. PMID: 31714937.
    Citations:    
  12. Gallagher T, Lipsitch M. Post-Exposure Effects of Vaccines on Infectious Diseases. Epidemiol Rev. 2019 Nov 04. PMID: 31680134.
    Citations:    
  13. Goldstein E, Finelli L, O'Halloran A, Liu P, Karaca Z, Steiner CA, Viboud C, Lipsitch M. Hospitalizations Associated with Respiratory Syncytial Virus and Influenza in Children, Including Children Diagnosed with Asthma. Epidemiology. 2019 11; 30(6):918-926. PMID: 31469696.
    Citations:    
  14. Lipsitch M, Shaman J. Comment on: 'Antibiotic footprint' as a communication tool to aid reduction of antibiotic consumption. J Antimicrob Chemother. 2019 Nov 01; 74(11):3404-3406. PMID: 31314102.
    Citations:    
  15. Abuelezam NN, Reshef YA, Novak D, Grad YH, Seage Iii GR, Mayer K, Lipsitch M. Interaction Patterns of Men Who Have Sex With Men on a Geosocial Networking Mobile App in Seven United States Metropolitan Areas: Observational Study. J Med Internet Res. 2019 09 12; 21(9):e13766. PMID: 31516124.
    Citations:    
  16. Lee RTC, Chang HH, Russell CA, Lipsitch M, Maurer-Stroh S. Influenza A Hemagglutinin Passage Bias Sites and Host Specificity Mutations. Cells. 2019 08 22; 8(9). PMID: 31443542.
    Citations:    
  17. Goldstein E, Olesen SW, Karaca Z, Steiner CA, Viboud C, Lipsitch M. Levels of outpatient prescribing for four major antibiotic classes and rates of septicemia hospitalization in adults in different US states - a statistical analysis. BMC Public Health. 2019 Aug 19; 19(1):1138. PMID: 31426780.
    Citations:    
  18. Eyal N, Kimmelman J, Holtzman LG, Lipsitch M. Regulating impact on bystanders in clinical trials: An unsettled frontier. Clin Trials. 2019 10; 16(5):450-454. PMID: 31368813.
    Citations:    
  19. MacFadden DR, Fisman DN, Hanage WP, Lipsitch M. The Relative Impact of Community and Hospital Antibiotic Use on the Selection of Extended-spectrum Beta-lactamase-producing Escherichia coli. Clin Infect Dis. 2019 Jun 18; 69(1):182-188. PMID: 30462185.
    Citations:    Fields:    
  20. McAdams D, Wollein Waldetoft K, Tedijanto C, Lipsitch M, Brown SP. Resistance diagnostics as a public health tool to combat antibiotic resistance: A model-based evaluation. PLoS Biol. 2019 05; 17(5):e3000250. PMID: 31095567.
    Citations:    
  21. Lehtinen S, Blanquart F, Lipsitch M, Fraser C. On the evolutionary ecology of multidrug resistance in bacteria. PLoS Pathog. 2019 05; 15(5):e1007763. PMID: 31083687.
    Citations:    
  22. Olesen SW, Lipsitch M, Grad YH. Response to comment on 'The distribution of antibiotic use and its association with antibiotic resistance'. Elife. 2019 05 03; 8. PMID: 31050649.
    Citations:    
  23. Lipsitch M. Challenges of Vaccine Effectiveness and Waning Studies. Clin Infect Dis. 2019 05 02; 68(10):1631-1633. PMID: 30204853.
    Citations:    Fields:    
  24. Lewnard JA, Tedijanto C, Cowling BJ, Lipsitch M. THE AUTHORS REPLY. Am J Epidemiol. 2019 04 01; 188(4):807-808. PMID: 30689694.
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  25. Hitchings MDT, Coldiron ME, Grais RF, Lipsitch M. Analysis of a meningococcal meningitis outbreak in Niger - potential effectiveness of reactive prophylaxis. PLoS Negl Trop Dis. 2019 03; 13(3):e0007077. PMID: 30856166.
    Citations:    
  26. Goldstein E, MacFadden DR, Karaca Z, Steiner CA, Viboud C, Lipsitch M. Antimicrobial resistance prevalence, rates of hospitalization with septicemia and rates of mortality with sepsis in adults in different US states. Int J Antimicrob Agents. 2019 Jul; 54(1):23-34. PMID: 30851403.
    Citations:    
  27. Yang A, Cai F, Lipsitch M. Herd immunity alters the conditions for performing dose schedule comparisons: an individual-based model of pneumococcal carriage. BMC Infect Dis. 2019 Mar 05; 19(1):227. PMID: 30836941.
    Citations:    
  28. Langwig KE, Gomes MGM, Clark MD, Kwitny M, Yamada S, Wargo AR, Lipsitch M. Limited available evidence supports theoretical predictions of reduced vaccine efficacy at higher exposure dose. Sci Rep. 2019 03 01; 9(1):3203. PMID: 30824732.
    Citations:    
  29. Mitchell PK, Azarian T, Croucher NJ, Callendrello A, Thompson CM, Pelton SI, Lipsitch M, Hanage WP. Population genomics of pneumococcal carriage in Massachusetts children following introduction of PCV-13. Microb Genom. 2019 02; 5(2). PMID: 30777813.
    Citations:    
  30. Kahn R, Hitchings M, Wang R, Bellan SE, Lipsitch M. Analyzing Vaccine Trials in Epidemics With Mild and Asymptomatic Infection. Am J Epidemiol. 2019 02 01; 188(2):467-474. PMID: 30329134.
    Citations:    Fields:    
  31. Olesen SW, Torrone EA, Papp JR, Kirkcaldy RD, Lipsitch M, Grad YH. Azithromycin Susceptibility Among Neisseria gonorrhoeae Isolates and Seasonal Macrolide Use. J Infect Dis. 2019 01 29; 219(4):619-623. PMID: 30239814.
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  32. Georgieva M, Buckee CO, Lipsitch M. Models of immune selection for multi-locus antigenic diversity of pathogens. Nat Rev Immunol. 2019 01; 19(1):55-62. PMID: 30479379.
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  33. Abuelezam NN, McCormick AW, Surface ED, Fussell T, Freedberg KA, Lipsitch M, Seage GR. Modelling the epidemiologic impact of achieving UNAIDS fast-track 90-90-90 and 95-95-95 targets in South Africa. Epidemiol Infect. 2019 01; 147:e122. PMID: 30869008.
    Citations:    
  34. Mahmud AS, Lipsitch M, Goldstein E. On the role of different age groups during pertussis epidemics in California, 2010 and 2014. Epidemiol Infect. 2019 01; 147:e184. PMID: 31063110.
    Citations:    
  35. Lipsitch M, Santillana M. Enhancing Situational Awareness to Prevent Infectious Disease Outbreaks from Becoming Catastrophic. Curr Top Microbiol Immunol. 2019; 424:59-74. PMID: 31292726.
    Citations:    
  36. Campo JJ, Le TQ, Pablo JV, Hung C, Teng AA, Tettelin H, Tate A, Hanage WP, Alderson MR, Liang X, Malley R, Lipsitch M, Croucher NJ. Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination. Elife. 2018 12 28; 7. PMID: 30592459.
    Citations:    Fields:    
  37. Tedijanto C, Olesen SW, Grad YH, Lipsitch M. Estimating the proportion of bystander selection for antibiotic resistance among potentially pathogenic bacterial flora. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):E11988-E11995. PMID: 30559213.
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  38. Sevilla JP, Bloom DE, Cadarette D, Jit M, Lipsitch M. Toward economic evaluation of the value of vaccines and other health technologies in addressing AMR. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):12911-12919. PMID: 30559203.
    Citations:    Fields:    
  39. Olesen SW, Barnett ML, MacFadden DR, Brownstein JS, Hernández-Díaz S, Lipsitch M, Grad YH. The distribution of antibiotic use and its association with antibiotic resistance. Elife. 2018 12 18; 7. PMID: 30560781.
    Citations:    Fields:    
  40. Relman DA, Lipsitch M. Microbiome as a tool and a target in the effort to address antimicrobial resistance. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):12902-12910. PMID: 30559176.
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  41. Lewnard JA, Tedijanto C, Cowling BJ, Lipsitch M. Measurement of Vaccine Direct Effects Under the Test-Negative Design. Am J Epidemiol. 2018 12 01; 187(12):2686-2697. PMID: 30099505.
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  42. Cai FY, Fussell T, Cobey S, Lipsitch M. Use of an individual-based model of pneumococcal carriage for planning a randomized trial of a whole-cell vaccine. PLoS Comput Biol. 2018 10; 14(10):e1006333. PMID: 30273332.
    Citations:    Fields:    Translation:HumansCells
  43. Lewnard JA, Tähtinen PA, Laine MK, Lindholm L, Jalava J, Huovinen P, Lipsitch M, Ruohola A. Impact of Antimicrobial Treatment for Acute Otitis Media on Carriage Dynamics of Penicillin-Susceptible and Penicillin-Nonsusceptible Streptococcus pneumoniae. J Infect Dis. 2018 09 22; 218(9):1356-1366. PMID: 29873739.
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  44. Eyal N, Lipsitch M, Bärnighausen T, Wikler D. Opinion: Risk to study nonparticipants: A procedural approach. Proc Natl Acad Sci U S A. 2018 08 07; 115(32):8051-8053. PMID: 30087210.
    Citations:    Fields:    Translation:Humans
  45. Kahn R, Rid A, Smith PG, Eyal N, Lipsitch M. Choices in vaccine trial design in epidemics of emerging infections. PLoS Med. 2018 08; 15(8):e1002632. PMID: 30086139.
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  46. Hitchings MDT, Lipsitch M, Wang R, Bellan SE. Competing Effects of Indirect Protection and Clustering on the Power of Cluster-Randomized Controlled Vaccine Trials. Am J Epidemiol. 2018 08 01; 187(8):1763-1771. PMID: 29522080.
    Citations: 1     Fields:    
  47. Atkins KE, Lipsitch M. Can antibiotic resistance be reduced by vaccinating against respiratory disease? Lancet Respir Med. 2018 11; 6(11):820-821. PMID: 30076121.
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  48. Olesen SW, Barnett ML, MacFadden DR, Lipsitch M, Grad YH. Trends in outpatient antibiotic use and prescribing practice among US older adults, 2011-15: observational study. BMJ. 2018 07 27; 362:k3155. PMID: 30054353.
    Citations:    Fields:    
  49. MacFadden DR, Lipsitch M, Olesen SW, Grad Y. Multidrug-resistant Neisseria gonorrhoeae: implications for future treatment strategies. Lancet Infect Dis. 2018 06; 18(6):599. PMID: 29856349.
    Citations: 1     Fields:    
  50. Blanquart F, Lehtinen S, Lipsitch M, Fraser C. The evolution of antibiotic resistance in a structured host population. J R Soc Interface. 2018 06; 15(143). PMID: 29925579.
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  51. Goldstein E, Worby CJ, Lipsitch M. On the Role of Different Age Groups and Pertussis Vaccines During the 2012 Outbreak in Wisconsin. Open Forum Infect Dis. 2018 May; 5(5):ofy082. PMID: 29942818.
    Citations:    
  52. Azarian T, Grant LR, Arnold BJ, Hammitt LL, Reid R, Santosham M, Weatherholtz R, Goklish N, Thompson CM, Bentley SD, O'Brien KL, Hanage WP, Lipsitch M. The impact of serotype-specific vaccination on phylodynamic parameters of Streptococcus pneumoniae and the pneumococcal pan-genome. PLoS Pathog. 2018 04; 14(4):e1006966. PMID: 29617440.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  53. Johansson MA, Reich NG, Meyers LA, Lipsitch M. Preprints: An underutilized mechanism to accelerate outbreak science. PLoS Med. 2018 04; 15(4):e1002549. PMID: 29614073.
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  54. Georgieva M, Kagedan L, Lu YJ, Thompson CM, Lipsitch M. Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant-Specific Immunity. mBio. 2018 03 13; 9(2). PMID: 29535198.
    Citations:    Fields:    Translation:HumansCells
  55. Kahn R, Hitchings M, Bellan S, Lipsitch M. Impact of stochastically generated heterogeneity in hazard rates on individually randomized vaccine efficacy trials. Clin Trials. 2018 04; 15(2):207-211. PMID: 29374974.
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  56. Arnold BJ, Gutmann MU, Grad YH, Sheppard SK, Corander J, Lipsitch M, Hanage WP. Weak Epistasis May Drive Adaptation in Recombining Bacteria. Genetics. 2018 03; 208(3):1247-1260. PMID: 29330348.
    Citations: 2     Fields:    Translation:Cells
  57. Goldstein E, Nguyen HH, Liu P, Viboud C, Steiner CA, Worby CJ, Lipsitch M. On the Relative Role of Different Age Groups During Epidemics Associated With Respiratory Syncytial Virus. J Infect Dis. 2018 01 04; 217(2):238-244. PMID: 29112722.
    Citations: 1     Fields:    
  58. Lipsitch M. Why Do Exceptionally Dangerous Gain-of-Function Experiments in Influenza? Methods Mol Biol. 2018; 1836:589-608. PMID: 30151594.
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  59. Halloran ME, Auranen K, Baird S, Basta NE, Bellan SE, Brookmeyer R, Cooper BS, DeGruttola V, Hughes JP, Lessler J, Lofgren ET, Longini IM, Onnela JP, Özler B, Seage GR, Smith TA, Vespignani A, Vynnycky E, Lipsitch M. Simulations for designing and interpreting intervention trials in infectious diseases. BMC Med. 2017 12 29; 15(1):223. PMID: 29287587.
    Citations:    Fields:    Translation:Humans
  60. Lipsitch M, Li LM, Patterson S, Trammel J, Juergens C, Gruber WC, Scott DA, Dagan R. Serotype-specific immune responses to pneumococcal conjugate vaccine among children are significantly correlated by individual: Analysis of randomized controlled trial data. Vaccine. 2018 01 25; 36(4):473-478. PMID: 29248266.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  61. Langwig KE, Wargo AR, Jones DR, Viss JR, Rutan BJ, Egan NA, Sá-Guimarães P, Kim MS, Kurath G, Gomes MGM, Lipsitch M. Vaccine Effects on Heterogeneity in Susceptibility and Implications for Population Health Management. mBio. 2017 11 21; 8(6). PMID: 29162706.
    Citations: 1