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Marc Lipsitch, D.Phil.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U54GM088558 (LIPSITCH, MARC) Sep 15, 2009 - Aug 31, 2019
    NIH/NIGMS
    MIDAS Center for Communicable Disease Dynamics
    Role: Principal Investigator
  2. U01GM076497 (LIPSITCH, MARC) Feb 1, 2006 - Jan 31, 2011
    NIH/NIGMS
    Methodological Approaches to Planning and Analysis of N*
    Role: Principal Investigator
  3. R21AI055825 (LIPSITCH, MARC) Apr 15, 2003 - Mar 31, 2006
    NIH/NIAID
    Epidemiologic Methods: Resistant Nosocomial Infections
    Role: Principal Investigator
  4. R01AI048935 (LIPSITCH, MARC) Feb 1, 2001 - Aug 31, 2017
    NIH/NIAID
    Mechanisms and Population Genomics of Pneumococcal Antigenic Diversity
    Role: Principal Investigator
  5. F32GM019182 (LIPSITCH, MARC) Dec 19, 1997
    NIH/NIGMS
    POPULATION DYNAMICS OF BACTERIAL INFECTION AND TREATMENT
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Hitchings MDT, Coldiron ME, Grais RF, Lipsitch M. Analysis of a meningococcal meningitis outbreak in Niger - potential effectiveness of reactive prophylaxis. PLoS Negl Trop Dis. 2019 Mar; 13(3):e0007077. PMID: 30856166.
    Citations:    
  2. Goldstein E, MacFadden DR, Karaca Z, Steiner CA, Viboud C, Lipsitch M. Antimicrobial resistance prevalence, rates of hospitalization with septicemia and rates of mortality with sepsis in adults in different US states. Int J Antimicrob Agents. 2019 Mar 06. PMID: 30851403.
    Citations:    
  3. Yang A, Cai F, Lipsitch M. Herd immunity alters the conditions for performing dose schedule comparisons: an individual-based model of pneumococcal carriage. BMC Infect Dis. 2019 Mar 05; 19(1):227. PMID: 30836941.
    Citations:    
  4. Langwig KE, Gomes MGM, Clark MD, Kwitny M, Yamada S, Wargo AR, Lipsitch M. Limited available evidence supports theoretical predictions of reduced vaccine efficacy at higher exposure dose. Sci Rep. 2019 Mar 01; 9(1):3203. PMID: 30824732.
    Citations:    
  5. Mitchell PK, Azarian T, Croucher NJ, Callendrello A, Thompson CM, Pelton SI, Lipsitch M, Hanage WP. Population genomics of pneumococcal carriage in Massachusetts children following introduction of PCV-13. Microb Genom. 2019 Feb; 5(2). PMID: 30777813.
    Citations:    
  6. Kahn R, Hitchings M, Wang R, Bellan SE, Lipsitch M. Analyzing Vaccine Trials in Epidemics With Mild and Asymptomatic Infection. Am J Epidemiol. 2019 Feb 01; 188(2):467-474. PMID: 30329134.
    Citations:    Fields:    
  7. Olesen SW, Torrone EA, Papp JR, Kirkcaldy RD, Lipsitch M, Grad YH. Azithromycin Susceptibility Among Neisseria gonorrhoeae Isolates and Seasonal Macrolide Use. J Infect Dis. 2019 Jan 29; 219(4):619-623. PMID: 30239814.
    Citations:    Fields:    
  8. Lewnard JA, Tedijanto C, Cowling BJ, Lipsitch M. Accounting for unobserved and differential susceptible time at risk in retrospective studies: response to Dean (2019). Am J Epidemiol. 2019 Jan 25. PMID: 30689694.
    Citations:    Fields:    
  9. Georgieva M, Buckee CO, Lipsitch M. Models of immune selection for multi-locus antigenic diversity of pathogens. Nat Rev Immunol. 2019 Jan; 19(1):55-62. PMID: 30479379.
    Citations:    Fields:    
  10. Abuelezam NN, McCormick AW, Surface ED, Fussell T, Freedberg KA, Lipsitch M, Seage GR. Modelling the epidemiologic impact of achieving UNAIDS fast-track 90-90-90 and 95-95-95 targets in South Africa. Epidemiol Infect. 2019 Jan; 147:e122. PMID: 30869008.
    Citations:    
  11. Campo JJ, Le TQ, Pablo JV, Hung C, Teng AA, Tettelin H, Tate A, Hanage WP, Alderson MR, Liang X, Malley R, Lipsitch M, Croucher NJ. Panproteome-wide analysis of antibody responses to whole cell pneumococcal vaccination. Elife. 2018 12 28; 7. PMID: 30592459.
    Citations:    Fields:    
  12. Tedijanto C, Olesen SW, Grad YH, Lipsitch M. Estimating the proportion of bystander selection for antibiotic resistance among potentially pathogenic bacterial flora. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):E11988-E11995. PMID: 30559213.
    Citations:    Fields:    
  13. Sevilla JP, Bloom DE, Cadarette D, Jit M, Lipsitch M. Toward economic evaluation of the value of vaccines and other health technologies in addressing AMR. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):12911-12919. PMID: 30559203.
    Citations:    Fields:    
  14. Olesen SW, Barnett ML, MacFadden DR, Brownstein JS, Hernández-Díaz S, Lipsitch M, Grad YH. The distribution of antibiotic use and its association with antibiotic resistance. Elife. 2018 12 18; 7. PMID: 30560781.
    Citations:    Fields:    
  15. Relman DA, Lipsitch M. Microbiome as a tool and a target in the effort to address antimicrobial resistance. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):12902-12910. PMID: 30559176.
    Citations:    Fields:    
  16. Lewnard JA, Tedijanto C, Cowling BJ, Lipsitch M. Measurement of Vaccine Direct Effects Under the Test-Negative Design. Am J Epidemiol. 2018 Dec 01; 187(12):2686-2697. PMID: 30099505.
    Citations:    Fields:    
  17. MacFadden DR, Fisman DN, Hanage WP, Lipsitch M. The Relative Impact of Community and Hospital Antibiotic Use on the Selection of Extended-Spectrum Beta-lactamase-Producing Escherichia coli. Clin Infect Dis. 2018 Nov 20. PMID: 30462185.
    Citations:    Fields:    
  18. Cai FY, Fussell T, Cobey S, Lipsitch M. Use of an individual-based model of pneumococcal carriage for planning a randomized trial of a whole-cell vaccine. PLoS Comput Biol. 2018 10; 14(10):e1006333. PMID: 30273332.
    Citations:    Fields:    Translation:HumansCells
  19. Lewnard JA, Tähtinen PA, Laine MK, Lindholm L, Jalava J, Huovinen P, Lipsitch M, Ruohola A. Impact of Antimicrobial Treatment for Acute Otitis Media on Carriage Dynamics of Penicillin-Susceptible and Penicillin-Nonsusceptible Streptococcus pneumoniae. J Infect Dis. 2018 Sep 22; 218(9):1356-1366. PMID: 29873739.
    Citations:    Fields:    
  20. Lipsitch M. Challenges of vaccine effectiveness and waning studies. Clin Infect Dis. 2018 Sep 10. PMID: 30204853.
    Citations:    Fields:    
  21. Eyal N, Lipsitch M, Bärnighausen T, Wikler D. Opinion: Risk to study nonparticipants: A procedural approach. Proc Natl Acad Sci U S A. 2018 08 07; 115(32):8051-8053. PMID: 30087210.
    Citations:    Fields:    Translation:Humans
  22. Kahn R, Rid A, Smith PG, Eyal N, Lipsitch M. Choices in vaccine trial design in epidemics of emerging infections. PLoS Med. 2018 Aug; 15(8):e1002632. PMID: 30086139.
    Citations:    Fields:    
  23. Hitchings MDT, Lipsitch M, Wang R, Bellan SE. Competing Effects of Indirect Protection and Clustering on the Power of Cluster-Randomized Controlled Vaccine Trials. Am J Epidemiol. 2018 Aug 01; 187(8):1763-1771. PMID: 29522080.
    Citations: 1     Fields:    
  24. Atkins KE, Lipsitch M. Can antibiotic resistance be reduced by vaccinating against respiratory disease? Lancet Respir Med. 2018 11; 6(11):820-821. PMID: 30076121.
    Citations:    Fields:    
  25. Olesen SW, Barnett ML, MacFadden DR, Lipsitch M, Grad YH. Trends in outpatient antibiotic use and prescribing practice among US older adults, 2011-15: observational study. BMJ. 2018 07 27; 362:k3155. PMID: 30054353.
    Citations:    Fields:    
  26. MacFadden DR, Lipsitch M, Olesen SW, Grad Y. Multidrug-resistant Neisseria gonorrhoeae: implications for future treatment strategies. Lancet Infect Dis. 2018 06; 18(6):599. PMID: 29856349.
    Citations: 1     Fields:    
  27. Blanquart F, Lehtinen S, Lipsitch M, Fraser C. The evolution of antibiotic resistance in a structured host population. J R Soc Interface. 2018 Jun; 15(143). PMID: 29925579.
    Citations:    Fields:    
  28. Goldstein E, Worby CJ, Lipsitch M. On the Role of Different Age Groups and Pertussis Vaccines During the 2012 Outbreak in Wisconsin. Open Forum Infect Dis. 2018 May; 5(5):ofy082. PMID: 29942818.
    Citations:    
  29. Azarian T, Grant LR, Arnold BJ, Hammitt LL, Reid R, Santosham M, Weatherholtz R, Goklish N, Thompson CM, Bentley SD, O'Brien KL, Hanage WP, Lipsitch M. The impact of serotype-specific vaccination on phylodynamic parameters of Streptococcus pneumoniae and the pneumococcal pan-genome. PLoS Pathog. 2018 04; 14(4):e1006966. PMID: 29617440.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  30. Johansson MA, Reich NG, Meyers LA, Lipsitch M. Preprints: An underutilized mechanism to accelerate outbreak science. PLoS Med. 2018 04; 15(4):e1002549. PMID: 29614073.
    Citations:    Fields:    
  31. Georgieva M, Kagedan L, Lu YJ, Thompson CM, Lipsitch M. Antigenic Variation in Streptococcus pneumoniae PspC Promotes Immune Escape in the Presence of Variant-Specific Immunity. MBio. 2018 03 13; 9(2). PMID: 29535198.
    Citations:    Fields:    Translation:HumansCells
  32. Kahn R, Hitchings M, Bellan S, Lipsitch M. Impact of stochastically generated heterogeneity in hazard rates on individually randomized vaccine efficacy trials. Clin Trials. 2018 04; 15(2):207-211. PMID: 29374974.
    Citations:    Fields:    
  33. Arnold BJ, Gutmann MU, Grad YH, Sheppard SK, Corander J, Lipsitch M, Hanage WP. Weak Epistasis May Drive Adaptation in Recombining Bacteria. Genetics. 2018 03; 208(3):1247-1260. PMID: 29330348.
    Citations: 2     Fields:    Translation:Cells
  34. Goldstein E, Nguyen HH, Liu P, Viboud C, Steiner CA, Worby CJ, Lipsitch M. On the Relative Role of Different Age Groups During Epidemics Associated With Respiratory Syncytial Virus. J Infect Dis. 2018 Jan 04; 217(2):238-244. PMID: 29112722.
    Citations: 1     Fields:    
  35. Lipsitch M. Why Do Exceptionally Dangerous Gain-of-Function Experiments in Influenza? Methods Mol Biol. 2018; 1836:589-608. PMID: 30151594.
    Citations:    Fields:    
  36. Halloran ME, Auranen K, Baird S, Basta NE, Bellan SE, Brookmeyer R, Cooper BS, DeGruttola V, Hughes JP, Lessler J, Lofgren ET, Longini IM, Onnela JP, Özler B, Seage GR, Smith TA, Vespignani A, Vynnycky E, Lipsitch M. Simulations for designing and interpreting intervention trials in infectious diseases. BMC Med. 2017 12 29; 15(1):223. PMID: 29287587.
    Citations:    Fields:    Translation:Humans
  37. Lipsitch M, Li LM, Patterson S, Trammel J, Juergens C, Gruber WC, Scott DA, Dagan R. Serotype-specific immune responses to pneumococcal conjugate vaccine among children are significantly correlated by individual: Analysis of randomized controlled trial data. Vaccine. 2018 01 25; 36(4):473-478. PMID: 29248266.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  38. Langwig KE, Wargo AR, Jones DR, Viss JR, Rutan BJ, Egan NA, Sá-Guimarães P, Kim MS, Kurath G, Gomes MGM, Lipsitch M. Vaccine Effects on Heterogeneity in Susceptibility and Implications for Population Health Management. MBio. 2017 11 21; 8(6). PMID: 29162706.
    Citations: 1     Fields:    Translation:HumansAnimalsPHPublic Health
  39. Worby CJ, Lipsitch M, Hanage WP. Shared Genomic Variants: Identification of Transmission Routes Using Pathogen Deep-Sequence Data. Am J Epidemiol. 2017 Nov 15; 186(10):1209-1216. PMID: 29149252.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  40. Lewnard JA, Givon-Lavi N, Weinberger DM, Lipsitch M, Dagan R. Pan-serotype Reduction in Progression of Streptococcus pneumoniae to Otitis Media After Rollout of Pneumococcal Conjugate Vaccines. Clin Infect Dis. 2017 Nov 13; 65(11):1853-1861. PMID: 29020218.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  41. Masala GL, Lipsitch M, Bottomley C, Flasche S. Exploring the role of competition induced by non-vaccine serotypes for herd protection following pneumococcal vaccination. J R Soc Interface. 2017 11; 14(136). PMID: 29093131.
    Citations:    Fields:    Translation:HumansCellsPHPublic Health
  42. Corander J, Fraser C, Gutmann MU, Arnold B, Hanage WP, Bentley SD, Lipsitch M, Croucher NJ. Frequency-dependent selection in vaccine-associated pneumococcal population dynamics. Nat Ecol Evol. 2017 Dec; 1(12):1950-1960. PMID: 29038424.
    Citations: 8     Fields:    Translation:Cells
  43. Lee GM, Kleinman K, Pelton S, Lipsitch M, Huang SS, Lakoma M, Dutta-Linn M, Rett M, Hanage WP, Finkelstein JA. Immunization, Antibiotic Use, and Pneumococcal Colonization Over a 15-Year Period. Pediatrics. 2017 Nov; 140(5). PMID: 28978716.
    Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
  44. Cobey S, Baskerville EB, Colijn C, Hanage W, Fraser C, Lipsitch M. Host population structure and treatment frequency maintain balancing selection on drug resistance. J R Soc Interface. 2017 08; 14(133). PMID: 28835542.
    Citations:    Fields:    Translation:HumansAnimalsCells
  45. Lipsitch M. If a Global Catastrophic Biological Risk Materializes, at What Stage Will We Recognize It? Health Secur. 2017 Jul/Aug; 15(4):331-334. PMID: 28745911.
    Citations:    Fields:    Translation:HumansPHPublic Health
  46. Lipsitch M, Eyal N. Improving vaccine trials in infectious disease emergencies. Science. 2017 07 14; 357(6347):153-156. PMID: 28706038.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  47. Eyal N, Lipsitch M. Vaccine testing for emerging infections: the case for individual randomisation. J Med Ethics. 2017 09; 43(9):625-631. PMID: 28396558.
    Citations: 3     Fields:    Translation:HumansPHPublic Health
  48. McCormick AW, Abuelezam NN, Fussell T, Seage GR, Lipsitch M. Displacement of sexual partnerships in trials of sexual behavior interventions: A model-based assessment of consequences. Epidemics. 2017 09; 20:94-101. PMID: 28416219.
    Citations: 1     Fields:    Translation:Humans
  49. Hitchings MD, Grais RF, Lipsitch M. Using simulation to aid trial design: Ring-vaccination trials. PLoS Negl Trop Dis. 2017 03; 11(3):e0005470. PMID: 28328984.
    Citations: 3     Fields:    
  50. Azarian T, Grant LR, Georgieva M, Hammitt LL, Reid R, Bentley SD, Goldblatt D, Santosham M, Weatherholtz R, Burbidge P, Goklish N, Thompson CM, Hanage WP, O'Brien KL, Lipsitch M. Association of Pneumococcal Protein Antigen Serology With Age and Antigenic Profile of Colonizing Isolates. J Infect Dis. 2017 03 01; 215(5):713-722. PMID: 28035010.
    Citations: 4     Fields:    Translation:Humans
  51. Worby CJ, Wallinga J, Lipsitch M, Goldstein E. Population effect of influenza vaccination under co-circulation of non-vaccine variants and the case for a bivalent A/H3N2 vaccine component. Epidemics. 2017 06; 19:74-82. PMID: 28262588.
    Citations:    Fields:    Translation:HumansCells
  52. Grad YH, Lipsitch M. Reply to Allan-Blitz and Klausner. J Infect Dis. 2017 Feb 01; 215(3):491-492. PMID: 28003355.
    Citations:    Fields:    
  53. Lehtinen S, Blanquart F, Croucher NJ, Turner P, Lipsitch M, Fraser C. Evolution of antibiotic resistance is linked to any genetic mechanism affecting bacterial duration of carriage. Proc Natl Acad Sci U S A. 2017 01 31; 114(5):1075-1080. PMID: 28096340.
    Citations: 9     Fields:    Translation:HumansCells
  54. Croucher NJ, Campo JJ, Le TQ, Liang X, Bentley SD, Hanage WP, Lipsitch M. Diverse evolutionary patterns of pneumococcal antigens identified by pangenome-wide immunological screening. Proc Natl Acad Sci U S A. 2017 01 17; 114(3):E357-E366. PMID: 28053228.
    Citations: 7     Fields:    Translation:HumansCells
  55. Goldstein E, Pitzer VE, O'Hagan JJ, Lipsitch M. Temporally Varying Relative Risks for Infectious Diseases: Implications for Infectious Disease Control. Epidemiology. 2017 01; 28(1):136-144. PMID: 27748685.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  56. Lipsitch M, Jha A, Simonsen L. Observational studies and the difficult quest for causality: lessons from vaccine effectiveness and impact studies. Int J Epidemiol. 2016 12 01; 45(6):2060-2074. PMID: 27453361.
    Citations: 12     Fields:    Translation:Humans
  57. Leung K, Lipsitch M, Yuen KY, Wu JT. Monitoring the fitness of antiviral-resistant influenza strains during an epidemic: a mathematical modelling study. Lancet Infect Dis. 2017 03; 17(3):339-347. PMID: 27914853.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  58. Lipsitch M, Barclay W, Raman R, Russell CJ, Belser JA, Cobey S, Kasson PM, Lloyd-Smith JO, Maurer-Stroh S, Riley S, Beauchemin CA, Bedford T, Friedrich TC, Handel A, Herfst S, Murcia PR, Roche B, Wilke CO, Russell CA. Viral factors in influenza pandemic risk assessment. Elife. 2016 11 11; 5. PMID: 27834632.
    Citations: 12     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  59. Wu JT, Peak CM, Leung GM, Lipsitch M. Fractional dosing of yellow fever vaccine to extend supply: a modelling study. Lancet. 2016 12 10; 388(10062):2904-2911. PMID: 27837923.
    Citations: 8     Fields:    Translation:HumansPHPublic Health
  60. Grad YH, Harris SR, Kirkcaldy RD, Green AG, Marks DS, Bentley SD, Trees D, Lipsitch M. Genomic Epidemiology of Gonococcal Resistance to Extended-Spectrum Cephalosporins, Macrolides, and Fluoroquinolones in the United States, 2000-2013. J Infect Dis. 2016 11 15; 214(10):1579-1587. PMID: 27638945.
    Citations: 17     Fields:    Translation:HumansCells
  61. Lipsitch M, Cowling BJ. Zika vaccine trials. Science. 2016 09 09; 353(6304):1094-5. PMID: 27609872.
    Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
  62. Lipsitch M. Comment on "Gain-of-Function Research and the Relevance to Clinical Practice". J Infect Dis. 2016 10 15; 214(8):1284-5. PMID: 27503367.
    Citations:    Fields:    Translation:Cells
  63. García-Albéniz X, Hsu J, Lipsitch M, Bretthauer M, Logan RW, Hernández-Díaz S, Hernán MA. Colonoscopy and Risk of Infective Endocarditis in the Elderly. J Am Coll Cardiol. 2016 08 02; 68(5