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Zhi-Min Yuan, Ph.D.

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Overview
Yuan Laboratory Research Focus:
The cellular responses to stress in general, and to radiation in particular, are highly coordinated processes, which, when deregulated, may contribute to the development of stress-associated pathologies and diseases including aging, diabetes and cancer. Our research focuses on elucidation of signaling mechanisms that regulate cellular stress responses and on examining how stress signals affect cell behaviors in the context of cancer. Our long term goal is to gain a better understanding of the biology of carcinogenesis, which would then allow us to design effective strategies for prevention, early detection, and treatment of cancer.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01CA233558 (YUAN, ZHI-MIN) May 10, 2019 - Apr 30, 2024
    NIH/NCI
    Target MDM2/MDMX for reducing normal tissue toxicity induced by chemotherapy
    Role: Principal Investigator
  2. R01CA183074 (YUAN, ZHI-MIN) Apr 1, 2014 - Mar 31, 2019
    NIH/NCI
    A p53/NFkB-mediated metabolic mechanism for chemotherapy protection
    Role: Principal Investigator
  3. R01CA167814 (YUAN, ZHI-MIN) Sep 7, 2012 - Jul 31, 2017
    NIH/NCI
    Modulation of p53 function by tyrosine kinase networks
    Role: Principal Investigator
  4. R01CA125144 (YUAN, ZHI-MIN) Sep 15, 2008 - Jun 30, 2012
    NIH/NCI
    The role of beclin 1/class III PI-3 kinase and p53 in breast tumorigenesis
    Role: Principal Investigator
  5. R01CA085679 (YUAN, ZHI-MIN) Apr 1, 2000 - May 31, 2010
    NIH/NCI
    MDM2 and MDMX function together as the p53 E3 ligase
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. de Polo A, Luo Z, Gerarduzzi C, Chen X, Little JB, Yuan ZM. AXL receptor signalling suppresses p53 in melanoma through stabilization of the MDMX-MDM2 complex. J Mol Cell Biol. 2017 04 01; 9(2):154-165. PMID: 27927748.
    Citations: 3     Fields:    Translation:HumansCells
  2. Gerarduzzi C, de Polo A, Liu XS, El Kharbili M, Little JB, Yuan ZM. Human epidermal growth factor receptor 4 (Her4) Suppresses p53 Protein via Targeting the MDMX-MDM2 Protein Complex: IMPLICATION OF A NOVEL MDMX SER-314 PHOSPHOSITE. J Biol Chem. 2016 Dec 09; 291(50):25937-25949. PMID: 27777309.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  3. Gong L, Pan X, Yuan ZM, Peng J, Chen J. p53 coordinates with ?133p53 isoform to promote cell survival under low-level oxidative stress. J Mol Cell Biol. 2016 Feb; 8(1):88-90. PMID: 26705306.
    Citations: 4     Fields:    Translation:HumansCells
  4. Liu XS, Genet MD, Haines JE, Mehanna EK, Wu S, Chen HI, Chen Y, Qureshi AA, Han J, Chen X, Fisher DE, Pandolfi PP, Yuan ZM. ZBTB7A Suppresses Melanoma Metastasis by Transcriptionally Repressing MCAM. Mol Cancer Res. 2015 Aug; 13(8):1206-17. PMID: 25995384.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  5. Liu XS, Little JB, Yuan ZM. Glycolytic metabolism influences global chromatin structure. Oncotarget. 2015 Feb 28; 6(6):4214-25. PMID: 25784656.
    Citations: 17     Fields:    Translation:HumansCells
  6. Liu XS, Haines JE, Mehanna EK, Genet MD, Ben-Sahra I, Asara JM, Manning BD, Yuan ZM. ZBTB7A acts as a tumor suppressor through the transcriptional repression of glycolysis. Genes Dev. 2014 Sep 01; 28(17):1917-28. PMID: 25184678.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  7. Ganapathy S, Xiao S, Yang M, Qi M, Choi DE, Ha CS, Little JB, Yuan ZM. A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection. J Biol Chem. 2014 Feb 21; 289(8):5340-7. PMID: 24391088.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  8. Tsai KK, Stuart J, Chuang YY, Little JB, Yuan ZM. Low-dose radiation-induced senescent stromal fibroblasts render nearby breast cancer cells radioresistant. Radiat Res. 2009 Sep; 172(3):306-13. PMID: 19708779.
    Citations: 11     Fields:    Translation:HumansCells
  9. Huang Y, Zhang J, McHenry KT, Kim MM, Zeng W, Lopez-Pajares V, Dibble CC, Mizgerd JP, Yuan ZM. Induction of cytoplasmic accumulation of p53: a mechanism for low levels of arsenic exposure to predispose cells for malignant transformation. Cancer Res. 2008 Nov 15; 68(22):9131-6. PMID: 19010883.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  10. Lopez-Pajares V, Kim MM, Yuan ZM. Phosphorylation of MDMX mediated by Akt leads to stabilization and induces 14-3-3 binding. J Biol Chem. 2008 May 16; 283(20):13707-13. PMID: 18356162.
    Citations: 26     Fields:    Translation:HumansCells
  11. Kawai H, Lopez-Pajares V, Kim MM, Wiederschain D, Yuan ZM. RING domain-mediated interaction is a requirement for MDM2's E3 ligase activity. Cancer Res. 2007 Jul 01; 67(13):6026-30. PMID: 17616658.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  12. Wiederschain D, Yuan ZM. Functional inactivation of P53 as a potential mechanism of MLL leukemogenesis. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006 Oct; 31(5):617-20. PMID: 17062917.
    Citations:    Fields:    Translation:HumansCells
  13. Stuart JR, Gonzalez FH, Kawai H, Yuan ZM. c-Abl interacts with the WAVE2 signaling complex to induce membrane ruffling and cell spreading. J Biol Chem. 2006 Oct 20; 281(42):31290-7. PMID: 16899465.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  14. Stuart JR, Kawai H, Tsai KK, Chuang EY, Yuan ZM. c-Abl regulates early growth response protein (EGR1) in response to oxidative stress. Oncogene. 2005 Dec 08; 24(55):8085-92. PMID: 16091742.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  15. Tsai KK, Chuang EY, Little JB, Yuan ZM. Cellular mechanisms for low-dose ionizing radiation-induced perturbation of the breast tissue microenvironment. Cancer Res. 2005 Aug 01; 65(15):6734-44. PMID: 16061655.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  16. Wiederschain D, Kawai H, Shilatifard A, Yuan ZM. Multiple mixed lineage leukemia (MLL) fusion proteins suppress p53-mediated response to DNA damage. J Biol Chem. 2005 Jul 01; 280(26):24315-21. PMID: 15851483.
    Citations: 22     Fields:    Translation:HumansCells
  17. Kawai H, Wiederschain D, Kitao H, Stuart J, Tsai KK, Yuan ZM. DNA damage-induced MDMX degradation is mediated by MDM2. J Biol Chem. 2003 Nov 14; 278(46):45946-53. PMID: 12963717.
    Citations: 79     Fields:    Translation:HumansCells
  18. Kawai H, Wiederschain D, Yuan ZM. Critical contribution of the MDM2 acidic domain to p53 ubiquitination. Mol Cell Biol. 2003 Jul; 23(14):4939-47. PMID: 12832479.
    Citations: 52     Fields:    Translation:AnimalsCells
  19. Tsai KK, Yuan ZM. c-Abl stabilizes p73 by a phosphorylation-augmented interaction. Cancer Res. 2003 Jun 15; 63(12):3418-24. PMID: 12810679.
    Citations: 37     Fields:    Translation:HumansCells
  20. Wiederschain D, Kawai H, Gu J, Shilatifard A, Yuan ZM. Molecular basis of p53 functional inactivation by the leukemic protein MLL-ELL. Mol Cell Biol. 2003 Jun; 23(12):4230-46. PMID: 12773566.
    Citations: 16     Fields:    Translation:HumansCells
  21. Kitao H, Yuan ZM. Regulation of ionizing radiation-induced Rad52 nuclear foci formation by c-Abl-mediated phosphorylation. J Biol Chem. 2002 Dec 13; 277(50):48944-8. PMID: 12379650.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  22. Kawai H, Nie L, Yuan ZM. Inactivation of NF-kappaB-dependent cell survival, a novel mechanism for the proapoptotic function of c-Abl. Mol Cell Biol. 2002 Sep; 22(17):6079-88. PMID: 12167702.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  23. Gu J, Kawai H, Nie L, Kitao H, Wiederschain D, Jochemsen AG, Parant J, Lozano G, Yuan ZM. Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. J Biol Chem. 2002 May 31; 277(22):19251-4. PMID: 11953423.
    Citations: 105     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.