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Gabriel Birrane, PH.D.

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This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
X-ray Crystallography Core (BIDMC) - Core services (5), Instruments (6), Protocols (4) and Software (4)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong LG, Young SG. Lipoprotein lipase is active as a monomer. Proc Natl Acad Sci U S A. 2019 Mar 08. PMID: 30850549.
    Citations:    
  2. Birrane G, Dassier AL, Romashko A, Lundberg D, Holmes K, Cottle T, Norton AW, Zhang B, Concino MF, Meiyappan M. Structural characterization of the a-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B. J Struct Biol. 2019 Mar 01; 205(3):65-71. PMID: 30802506.
    Citations:    
  3. Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M. Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc Natl Acad Sci U S A. 2019 01 29; 116(5):1723-1732. PMID: 30559189.
    Citations:    Fields:    
  4. Borges TJ, Murakami N, Machado FD, Murshid A, Lang BJ, Lopes RL, Bellan LM, Uehara M, Antunes KH, Pérez-Saéz MJ, Birrane G, Vianna P, Gonçalves JIB, Zanin RF, Azzi J, Abdi R, Ishido S, Shin JS, Souza APD, Calderwood SK, Riella LV, Bonorino C. March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity. Nat Commun. 2018 08 28; 9(1):3482. PMID: 30154416.
    Citations:    Fields:    Translation:AnimalsCells
  5. Elf S, Abdelfattah NS, Baral AJ, Beeson D, Rivera JF, Ko A, Florescu N, Birrane G, Chen E, Mullally A. Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN. Blood. 2018 02 15; 131(7):782-786. PMID: 29288169.
    Citations:    Fields:    Translation:HumansCells
  6. Zhang W, Tam CP, Walton T, Fahrenbach AC, Birrane G, Szostak JW. Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex. Proc Natl Acad Sci U S A. 2017 07 18; 114(29):7659-7664. PMID: 28673998.
    Citations: 1     Fields:    Translation:Cells
  7. Sharma AK, Birrane G, Anklin C, Rigby AC, Alper SL. NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Ia leucine zipper in vascular function. J Biol Chem. 2017 04 28; 292(17):7052-7065. PMID: 28280239.
    Citations:    Fields:    Translation:AnimalsCells
  8. Feng D, Steinke JM, Krishnan R, Birrane G, Pollak MR. Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing. PLoS One. 2016; 11(12):e0167467. PMID: 27977723.
    Citations: 1     Fields:    Translation:Humans
  9. Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, Garlish R, Neale H, Doyle C, Moore A, Hotamisligil GS. Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. Sci Transl Med. 2015 Dec 23; 7(319):319ra205. PMID: 26702093.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  10. Bunch H, Zheng X, Burkholder A, Dillon ST, Motola S, Birrane G, Ebmeier CC, Levine S, Fargo D, Hu G, Taatjes DJ, Calderwood SK. TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release. Nat Struct Mol Biol. 2014 Oct; 21(10):876-83. PMID: 25173174.
    Citations: 26     Fields:    Translation:HumansCells
  11. Birrane G, Bhyravbhatla B, Navia MA. Synthesis of Aspartame by Thermolysin: An X-ray Structural Study. ACS Med Chem Lett. 2014 Jun 12; 5(6):706-10. PMID: 24944748; PMCID: PMC4060929.
    Citations:    
  12. Choy WW, Datta D, Geiger CA, Birrane G, Grant MA. Crystallization and preliminary X-ray analysis of a complex of the FOXO1 and Ets1 DNA-binding domains and DNA. Acta Crystallogr F Struct Biol Commun. 2014 Jan; 70(Pt 1):44-8. PMID: 24419615.
    Citations: 1     Fields:    Translation:HumansCells
  13. Birrane G, Li H, Yang S, Tachado SD, Seng S. Cigarette smoke induces nuclear translocation of heme oxygenase 1 (HO-1) in prostate cancer cells: nuclear HO-1 promotes vascular endothelial growth factor secretion. Int J Oncol. 2013 Jun; 42(6):1919-28. PMID: 23591596; PMCID: PMC3699615.
    Citations: 9     Fields:    Translation:HumansCells
  14. Birrane G, Mulvaney EP, Pal R, Kinsella BT, Kocher O. Molecular analysis of the prostacyclin receptor's interaction with the PDZ1 domain of its adaptor protein PDZK1. PLoS One. 2013; 8(2):e53819. PMID: 23457445.
    Citations: 2     Fields:    Translation:Cells
  15. Kocher O, Birrane G, Yesilaltay A, Shechter S, Pal R, Daniels K, Krieger M. Identification of the PDZ3 domain of the adaptor protein PDZK1 as a second, physiologically functional binding site for the C terminus of the high density lipoprotein receptor scavenger receptor class B type I. J Biol Chem. 2011 Jul 15; 286(28):25171-86. PMID: 21602281; PMCID: PMC3137089.
    Citations: 7     Fields:    Translation:AnimalsCells
  16. LeBleu V, Sund M, Sugimoto H, Birrane G, Kanasaki K, Finan E, Miller CA, Gattone VH, McLaughlin H, Shield CF, Kalluri R. Identification of the NC1 domain of {alpha}3 chain as critical for {alpha}3{alpha}4{alpha}5 type IV collagen network assembly. J Biol Chem. 2010 Dec 31; 285(53):41874-85. PMID: 20847057; PMCID: PMC3009915.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  17. Kocher O, Birrane G, Tsukamoto K, Fenske S, Yesilaltay A, Pal R, Daniels K, Ladias JA, Krieger M. In vitro and in vivo analysis of the binding of the C terminus of the HDL receptor scavenger receptor class B, type I (SR-BI), to the PDZ1 domain of its adaptor protein PDZK1. J Biol Chem. 2010 Nov 05; 285(45):34999-5010. PMID: 20739281.
    Citations: 8     Fields:    Translation:AnimalsCells
  18. Seng S, Avraham HK, Birrane G, Jiang S, Avraham S. Nuclear matrix protein (NRP/B) modulates the nuclear factor (Erythroid-derived 2)-related 2 (NRF2)-dependent oxidative stress response. J Biol Chem. 2010 Aug 20; 285(34):26190-8. PMID: 20511222; PMCID: PMC2924028.
    Citations: 6     Fields:    Translation:HumansCells
  19. Durney MA, Birrane G, Anklin C, Soni A, Ladias JA. Solution structure of the human Tax-interacting protein-1. J Biomol NMR. 2009 Nov; 45(3):329-34. PMID: 19685007.
    Citations: 3     Fields:    Translation:HumansCells
  20. Birrane G, Soni A, Ladias JA. Structural basis for DNA recognition by the human PAX3 homeodomain. Biochemistry. 2009 Feb 17; 48(6):1148-55. PMID: 19199574.
    Citations: 7     Fields:    Translation:HumansCells
  21. Seng S, Avraham HK, Birrane G, Jiang S, Li H, Katz G, Bass CE, Zagozdzon R, Avraham S. NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors. Oncogene. 2009 Jan 22; 28(3):378-89. PMID: 18981988.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  22. Eikesdal HP, Sugimoto H, Birrane G, Maeshima Y, Cooke VG, Kieran M, Kalluri R. Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15040-5. PMID: 18818312; PMCID: PMC2567489.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  23. Tischkowitz M, Hamel N, Carvalho MA, Birrane G, Soni A, van Beers EH, Joosse SA, Wong N, Novak D, Quenneville LA, Grist SA, Nederlof PM, Goldgar DE, Tavtigian SV, Monteiro AN, Ladias JA, Foulkes WD. Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach. Eur J Hum Genet. 2008 Jul; 16(7):820-32. PMID: 18285836.
    Citations: 14     Fields:    Translation:HumansCells
  24. Meiyappan M, Birrane G, Ladias JA. Structural basis for polyproline recognition by the FE65 WW domain. J Mol Biol. 2007 Sep 28; 372(4):970-80. PMID: 17686488.
    Citations: 14     Fields:    Translation:HumansCells
  25. Birrane G, Varma AK, Soni A, Ladias JA. Crystal structure of the BARD1 BRCT domains. Biochemistry. 2007 Jul 03; 46(26):7706-12. PMID: 17550235.
    Citations: 13     Fields:    Translation:HumansCells
  26. Baek K, Brown RS, Birrane G, Ladias JA. Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9. J Mol Biol. 2007 Feb 16; 366(2):563-73. PMID: 17169370.
    Citations: 11     Fields:    Translation:HumansCells
  27. Tiburu EK, Karp ES, Birrane G, Struppe JO, Chu S, Lorigan GA, Avraham S, Avraham HK. 31P and 2H relaxation studies of helix VII and the cytoplasmic helix of the human cannabinoid receptors utilizing solid-state NMR techniques. Biochemistry. 2006 Jun 13; 45(23):7356-65. PMID: 16752925.
    Citations: 3     Fields:    Translation:HumansCells
  28. Varma AK, Brown RS, Birrane G, Ladias JA. Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex. Biochemistry. 2005 Aug 23; 44(33):10941-6. PMID: 16101277.
    Citations: 41     Fields:    Translation:HumansCells
  29. Grassick A, Murray PG, Thompson R, Collins CM, Byrnes L, Birrane G, Higgins TM, Tuohy MG. Three-dimensional structure of a thermostable native cellobiohydrolase, CBH IB, and molecular characterization of the cel7 gene from the filamentous fungus, Talaromyces emersonii. Eur J Biochem. 2004 Nov; 271(22):4495-506. PMID: 15560790.
    Citations: 22     Fields:    Translation:AnimalsCells
  30. Grassick A, Birrane G, Tuohy M, Murray P, Higgins T. Crystallization and preliminary crystallographic analysis of the catalytic domain cellobiohydrolase I from Talaromyces emersonii. Acta Crystallogr D Biol Crystallogr. 2003 Jul; 59(Pt 7):1283-4. PMID: 12832787.
    Citations:    Fields:    Translation:AnimalsCells
  31. Birrane G, Chung J, Ladias JA. Novel mode of ligand recognition by the Erbin PDZ domain. J Biol Chem. 2003 Jan 17; 278(3):1399-402. PMID: 12444095.
    Citations: 37     Fields:    Translation:HumansCells
  32. Karthikeyan S, Leung T, Birrane G, Webster G, Ladias JA. Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains. J Mol Biol. 2001 May 18; 308(5):963-73. PMID: 11352585.
    Citations: 23     Fields:    Translation:HumansCells
  33. Webster G, Leung T, Karthikeyan S, Birrane G, Ladias JA. Crystallographic characterization of the PDZ1 domain of the human Na+/H+ exchanger regulatory factor. Acta Crystallogr D Biol Crystallogr. 2001 May; 57(Pt 5):714-6. PMID: 11320314.
    Citations: 2     Fields:    Translation:HumansCells
  34. Mac Sweeney A, Birrane G, Walsh MA, O'Connell T, Malthouse JP, Higgins TM. Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor. Acta Crystallogr D Biol Crystallogr. 2000 Mar; 56(Pt 3):280-6. PMID: 10713514.
    Citations: 6     Fields:    Translation:AnimalsCells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.