Harvard Catalyst Profiles

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Gabriel Birrane, Ph.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Young SG, Song W, Yang Y, Birrane G, Jiang H, Beigneux AP, Ploug M, Fong LG. A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism. Proc Natl Acad Sci U S A. 2022 09 06; 119(36):e2211136119. PMID: 36037340; PMCID: PMC9457329.
    Citations: 1     Fields:    Translation:HumansCells
  2. Song W, Beigneux AP, Winther AL, Kristensen KK, Grønnemose AL, Yang Y, Tu Y, Munguia P, Morales J, Jung H, de Jong PJ, Jung CJ, Miyashita K, Kimura T, Nakajima K, Murakami M, Birrane G, Jiang H, Tontonoz P, Ploug M, Fong LG, Young SG. Electrostatic sheathing of lipoprotein lipase is essential for its movement across capillary endothelial cells. J Clin Invest. 2022 03 01; 132(5). PMID: 35229724; PMCID: PMC8884915.
    Citations:    Fields:    Translation:AnimalsCells
  3. Gabba A, Bogucka A, Luz JG, Diniz A, Coelho H, Corzana F, Cañada FJ, Marcelo F, Murphy PV, Birrane G. Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen. Biochemistry. 2021 05 04; 60(17):1327-1336. PMID: 33724805.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Luz JG, Beigneux AP, Asamoto DK, He C, Song W, Allan CM, Morales J, Tu Y, Kwok A, Cottle T, Meiyappan M, Fong LG, Kim JE, Ploug M, Young SG, Birrane G. The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase. J Lipid Res. 2020 10; 61(10):1347-1359. PMID: 32690595.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  5. Feng D, Kumar M, Muntel J, Gurley SB, Birrane G, Stillman IE, Ding L, Wang M, Ahmed S, Schlondorff J, Alper SL, Ferrante T, Marquez SL, Ng CF, Novak R, Ingber DE, Steen H, Pollak MR. Phosphorylation of ACTN4 Leads to Podocyte Vulnerability and Proteinuric Glomerulosclerosis. J Am Soc Nephrol. 2020 07; 31(7):1479-1495. PMID: 32540856; PMCID: PMC7351002.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  6. Kulkarni R, Jiang S, Birrane G, Prasad A. Lymphocyte-specific protein 1 (LSP1) regulates bone marrow stromal cell antigen 2 (BST-2)-mediated intracellular trafficking of HIV-1 in dendritic cells. FEBS Lett. 2020 06; 594(12):1947-1959. PMID: 32279313.
    Citations: 2     Fields:    Translation:HumansCells
  7. Kristensen KK, Leth-Espensen KZ, Mertens HDT, Birrane G, Meiyappan M, Olivecrona G, Jørgensen TJD, Young SG, Ploug M. Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism. Proc Natl Acad Sci U S A. 2020 02 25; 117(8):4337-4346. PMID: 32034094; PMCID: PMC7049152.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  8. Giessen TW, Orlando BJ, Verdegaal AA, Chambers MG, Gardener J, Bell DC, Birrane G, Liao M, Silver PA. Large protein organelles form a new iron sequestration system with high storage capacity. Elife. 2019 07 08; 8. PMID: 31282860; PMCID: PMC6668986.
    Citations: 29     Fields:    Translation:Cells
  9. Young SG, Fong LG, Beigneux AP, Allan CM, He C, Jiang H, Nakajima K, Meiyappan M, Birrane G, Ploug M. GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism. Cell Metab. 2019 07 02; 30(1):51-65. PMID: 31269429; PMCID: PMC6662658.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  10. Beigneux AP, Allan CM, Sandoval NP, Cho GW, Heizer PJ, Jung RS, Stanhope KL, Havel PJ, Birrane G, Meiyappan M, Gill JE, Murakami M, Miyashita K, Nakajima K, Ploug M, Fong LG, Young SG. Lipoprotein lipase is active as a monomer. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6319-6328. PMID: 30850549; PMCID: PMC6442593.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  11. Birrane G, Dassier AL, Romashko A, Lundberg D, Holmes K, Cottle T, Norton AW, Zhang B, Concino MF, Meiyappan M. Structural characterization of the a-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B. J Struct Biol. 2019 03 01; 205(3):65-71. PMID: 30802506.
    Citations: 4     Fields:    Translation:HumansCells
  12. Birrane G, Beigneux AP, Dwyer B, Strack-Logue B, Kristensen KK, Francone OL, Fong LG, Mertens HDT, Pan CQ, Ploug M, Young SG, Meiyappan M. Structure of the lipoprotein lipase-GPIHBP1 complex that mediates plasma triglyceride hydrolysis. Proc Natl Acad Sci U S A. 2019 01 29; 116(5):1723-1732. PMID: 30559189; PMCID: PMC6358717.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  13. Borges TJ, Murakami N, Machado FD, Murshid A, Lang BJ, Lopes RL, Bellan LM, Uehara M, Antunes KH, Pérez-Saéz MJ, Birrane G, Vianna P, Gonçalves JIB, Zanin RF, Azzi J, Abdi R, Ishido S, Shin JS, Souza APD, Calderwood SK, Riella LV, Bonorino C. March1-dependent modulation of donor MHC II on CD103+ dendritic cells mitigates alloimmunity. Nat Commun. 2018 08 28; 9(1):3482. PMID: 30154416; PMCID: PMC6113260.
    Citations: 11     Fields:    Translation:AnimalsCells
  14. Elf S, Abdelfattah NS, Baral AJ, Beeson D, Rivera JF, Ko A, Florescu N, Birrane G, Chen E, Mullally A. Defining the requirements for the pathogenic interaction between mutant calreticulin and MPL in MPN. Blood. 2018 02 15; 131(7):782-786. PMID: 29288169; PMCID: PMC5814933.
    Citations: 43     Fields:    Translation:HumansCells
  15. Zhang W, Tam CP, Walton T, Fahrenbach AC, Birrane G, Szostak JW. Insight into the mechanism of nonenzymatic RNA primer extension from the structure of an RNA-GpppG complex. Proc Natl Acad Sci U S A. 2017 07 18; 114(29):7659-7664. PMID: 28673998; PMCID: PMC5530681.
    Citations: 14     Fields:    Translation:Cells
  16. Sharma AK, Birrane G, Anklin C, Rigby AC, Alper SL. NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Ia leucine zipper in vascular function. J Biol Chem. 2017 04 28; 292(17):7052-7065. PMID: 28280239.
    Citations: 1     Fields:    Translation:AnimalsCells
  17. Feng D, Steinke JM, Krishnan R, Birrane G, Pollak MR. Functional Validation of an Alpha-Actinin-4 Mutation as a Potential Cause of an Aggressive Presentation of Adolescent Focal Segmental Glomerulosclerosis: Implications for Genetic Testing. PLoS One. 2016; 11(12):e0167467. PMID: 27977723.
    Citations: 7     Fields:    Translation:Humans
  18. Burak MF, Inouye KE, White A, Lee A, Tuncman G, Calay ES, Sekiya M, Tirosh A, Eguchi K, Birrane G, Lightwood D, Howells L, Odede G, Hailu H, West S, Garlish R, Neale H, Doyle C, Moore A, Hotamisligil GS. Development of a therapeutic monoclonal antibody that targets secreted fatty acid-binding protein aP2 to treat type 2 diabetes. Sci Transl Med. 2015 Dec 23; 7(319):319ra205. PMID: 26702093.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  19. Bunch H, Zheng X, Burkholder A, Dillon ST, Motola S, Birrane G, Ebmeier CC, Levine S, Fargo D, Hu G, Taatjes DJ, Calderwood SK. TRIM28 regulates RNA polymerase II promoter-proximal pausing and pause release. Nat Struct Mol Biol. 2014 Oct; 21(10):876-83. PMID: 25173174.
    Citations: 65     Fields:    Translation:HumansCells
  20. Birrane G, Bhyravbhatla B, Navia MA. Synthesis of Aspartame by Thermolysin: An X-ray Structural Study. ACS Med Chem Lett. 2014 Jun 12; 5(6):706-10. PMID: 24944748.
    Citations: 6     
  21. Choy WW, Datta D, Geiger CA, Birrane G, Grant MA. Crystallization and preliminary X-ray analysis of a complex of the FOXO1 and Ets1 DNA-binding domains and DNA. Acta Crystallogr F Struct Biol Commun. 2014 Jan; 70(Pt 1):44-8. PMID: 24419615.
    Citations: 4     Fields:    Translation:HumansCells
  22. Birrane G, Li H, Yang S, Tachado SD, Seng S. Cigarette smoke induces nuclear translocation of heme oxygenase 1 (HO-1) in prostate cancer cells: nuclear HO-1 promotes vascular endothelial growth factor secretion. Int J Oncol. 2013 Jun; 42(6):1919-28. PMID: 23591596.
    Citations: 20     Fields:    Translation:HumansCells
  23. Birrane G, Mulvaney EP, Pal R, Kinsella BT, Kocher O. Molecular analysis of the prostacyclin receptor's interaction with the PDZ1 domain of its adaptor protein PDZK1. PLoS One. 2013; 8(2):e53819. PMID: 23457445; PMCID: PMC3566133.
    Citations: 2     Fields:    Translation:Cells
  24. Kocher O, Birrane G, Yesilaltay A, Shechter S, Pal R, Daniels K, Krieger M. Identification of the PDZ3 domain of the adaptor protein PDZK1 as a second, physiologically functional binding site for the C terminus of the high density lipoprotein receptor scavenger receptor class B type I. J Biol Chem. 2011 Jul 15; 286(28):25171-86. PMID: 21602281.
    Citations: 10     Fields:    Translation:AnimalsCells
  25. LeBleu V, Sund M, Sugimoto H, Birrane G, Kanasaki K, Finan E, Miller CA, Gattone VH, McLaughlin H, Shield CF, Kalluri R. Identification of the NC1 domain of {alpha}3 chain as critical for {alpha}3{alpha}4{alpha}5 type IV collagen network assembly. J Biol Chem. 2010 Dec 31; 285(53):41874-85. PMID: 20847057.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  26. Kocher O, Birrane G, Tsukamoto K, Fenske S, Yesilaltay A, Pal R, Daniels K, Ladias JA, Krieger M. In vitro and in vivo analysis of the binding of the C terminus of the HDL receptor scavenger receptor class B, type I (SR-BI), to the PDZ1 domain of its adaptor protein PDZK1. J Biol Chem. 2010 Nov 05; 285(45):34999-5010. PMID: 20739281.
    Citations: 12     Fields:    Translation:AnimalsCells
  27. Seng S, Avraham HK, Birrane G, Jiang S, Avraham S. Nuclear matrix protein (NRP/B) modulates the nuclear factor (Erythroid-derived 2)-related 2 (NRF2)-dependent oxidative stress response. J Biol Chem. 2010 Aug 20; 285(34):26190-8. PMID: 20511222.
    Citations: 8     Fields:    Translation:HumansCells
  28. Durney MA, Birrane G, Anklin C, Soni A, Ladias JA. Solution structure of the human Tax-interacting protein-1. J Biomol NMR. 2009 Nov; 45(3):329-34. PMID: 19685007.
    Citations: 3     Fields:    Translation:HumansCells
  29. Birrane G, Soni A, Ladias JA. Structural basis for DNA recognition by the human PAX3 homeodomain. Biochemistry. 2009 Feb 17; 48(6):1148-55. PMID: 19199574.
    Citations: 15     Fields:    Translation:HumansCells
  30. Seng S, Avraham HK, Birrane G, Jiang S, Li H, Katz G, Bass CE, Zagozdzon R, Avraham S. NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors. Oncogene. 2009 Jan 22; 28(3):378-89. PMID: 18981988.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  31. Eikesdal HP, Sugimoto H, Birrane G, Maeshima Y, Cooke VG, Kieran M, Kalluri R. Identification of amino acids essential for the antiangiogenic activity of tumstatin and its use in combination antitumor activity. Proc Natl Acad Sci U S A. 2008 Sep 30; 105(39):15040-5. PMID: 18818312; PMCID: PMC2567489.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  32. Tischkowitz M, Hamel N, Carvalho MA, Birrane G, Soni A, van Beers EH, Joosse SA, Wong N, Novak D, Quenneville LA, Grist SA, Nederlof PM, Goldgar DE, Tavtigian SV, Monteiro AN, Ladias JA, Foulkes WD. Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach. Eur J Hum Genet. 2008 Jul; 16(7):820-32. PMID: 18285836.
    Citations: 19     Fields:    Translation:HumansCells
  33. Meiyappan M, Birrane G, Ladias JAA. Structural basis for polyproline recognition by the FE65 WW domain. J Mol Biol. 2007 Sep 28; 372(4):970-980. PMID: 17686488; PMCID: PMC2693091.
    Citations: 22     Fields:    Translation:HumansCells
  34. Birrane G, Varma AK, Soni A, Ladias JA. Crystal structure of the BARD1 BRCT domains. Biochemistry. 2007 Jul 03; 46(26):7706-12. PMID: 17550235.
    Citations: 24     Fields:    Translation:HumansCells
  35. Baek K, Brown RS, Birrane G, Ladias JA. Crystal structure of human cyclin K, a positive regulator of cyclin-dependent kinase 9. J Mol Biol. 2007 Feb 16; 366(2):563-73. PMID: 17169370; PMCID: PMC1852425.
    Citations: 14     Fields:    Translation:HumansCells
  36. Tiburu EK, Karp ES, Birrane G, Struppe JO, Chu S, Lorigan GA, Avraham S, Avraham HK. 31P and 2H relaxation studies of helix VII and the cytoplasmic helix of the human cannabinoid receptors utilizing solid-state NMR techniques. Biochemistry. 2006 Jun 13; 45(23):7356-65. PMID: 16752925.
    Citations: 3     Fields:    Translation:HumansCells
  37. Varma AK, Brown RS, Birrane G, Ladias JA. Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex. Biochemistry. 2005 Aug 23; 44(33):10941-6. PMID: 16101277.
    Citations: 56     Fields:    Translation:HumansCells
  38. Grassick A, Murray PG, Thompson R, Collins CM, Byrnes L, Birrane G, Higgins TM, Tuohy MG. Three-dimensional structure of a thermostable native cellobiohydrolase, CBH IB, and molecular characterization of the cel7 gene from the filamentous fungus, Talaromyces emersonii. Eur J Biochem. 2004 Nov; 271(22):4495-506. PMID: 15560790.
    Citations: 28     Fields:    Translation:AnimalsCells
  39. Grassick A, Birrane G, Tuohy M, Murray P, Higgins T. Crystallization and preliminary crystallographic analysis of the catalytic domain cellobiohydrolase I from Talaromyces emersonii. Acta Crystallogr D Biol Crystallogr. 2003 Jul; 59(Pt 7):1283-4. PMID: 12832787.
    Citations:    Fields:    Translation:AnimalsCells
  40. Birrane G, Chung J, Ladias JA. Novel mode of ligand recognition by the Erbin PDZ domain. J Biol Chem. 2003 Jan 17; 278(3):1399-402. PMID: 12444095.
    Citations: 48     Fields:    Translation:HumansCells
  41. Karthikeyan S, Leung T, Birrane G, Webster G, Ladias JA. Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains. J Mol Biol. 2001 May 18; 308(5):963-73. PMID: 11352585.
    Citations: 28     Fields:    Translation:HumansCells
  42. Webster G, Leung T, Karthikeyan S, Birrane G, Ladias JA. Crystallographic characterization of the PDZ1 domain of the human Na+/H+ exchanger regulatory factor. Acta Crystallogr D Biol Crystallogr. 2001 May; 57(Pt 5):714-6. PMID: 11320314.
    Citations: 2     Fields:    Translation:HumansCells
  43. Mac Sweeney A, Birrane G, Walsh MA, O'Connell T, Malthouse JP, Higgins TM. Crystal structure of delta-chymotrypsin bound to a peptidyl chloromethyl ketone inhibitor. Acta Crystallogr D Biol Crystallogr. 2000 Mar; 56(Pt 3):280-6. PMID: 10713514.
    Citations: 7     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.