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profileAnders Michael Naar, Ph.D.

TitleProfessor of Cell Biology
InstitutionMassachusetts General Hospital
DepartmentCell Biology
AddressMassachusetts General Hospital
Room 7404, Cancer Center
149 13th Street
Charlestown MA 02129
Phone617/724-7942
Fax617/726-5637
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01DK094184     (NAAR, ANDERS M)Sep 24, 2011 - May 31, 2016
NIH/NIDDK
Regulation of cholesterol/lipid homeostasis by microRNA-33a/b
Role: Principal Investigator

R21DK084459     (NAAR, ANDERS M)Aug 5, 2009 - Jan 30, 2012
NIH/NIDDK
Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid Homeostasis
Role: Principal Investigator

R01DK078332     (NAAR, ANDERS M)Apr 1, 2007 - Mar 31, 2012
NIH/NIDDK
Regulation of Lipid Homeostasis in C. elegans
Role: Principal Investigator

R01GM071449     (NAAR, ANDERS M)Mar 1, 2005 - Feb 28, 2011
NIH/NIGMS
Activator-Targeted Subunits of the ARC/Mediator
Role: Principal Investigator

Collapse Bibliographic 
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Näär AM. Anti-atherosclerosis or No Anti-atherosclerosis: That is the miR-33 question. Arterioscler Thromb Vasc Biol. 2013 Mar; 33(3):447-8. PMID: 23407174; PMCID: PMC3880779.
  2. Näär AM. MiRs with a sweet tooth. Cell Metab. 2011 Aug 03; 14(2):149-50. PMID: 21803284; PMCID: PMC3880780.
  3. Näär AM, Thakur JK. Nuclear receptor-like transcription factors in fungi. Genes Dev. 2009 Feb 15; 23(4):419-32. PMID: 19240130.
    View in: PubMed
  4. Binné UK, Classon MK, Dick FA, Wei W, Rape M, Kaelin WG, Näär AM, Dyson NJ. Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exit. Nat Cell Biol. 2007 Feb; 9(2):225-32. PMID: 17187060.
    View in: PubMed
  5. Yang F, Vought BW, Satterlee JS, Walker AK, Jim Sun ZY, Watts JL, DeBeaumont R, Saito RM, Hyberts SG, Yang S, Macol C, Iyer L, Tjian R, van den Heuvel S, Hart AC, Wagner G, Näär AM. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Nature. 2006 Aug 10; 442(7103):700-4. PMID: 16799563.
    View in: PubMed
  6. Baillat D, Hakimi MA, Näär AM, Shilatifard A, Cooch N, Shiekhattar R. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell. 2005 Oct 21; 123(2):265-76. PMID: 16239144.
    View in: PubMed
  7. Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege FC, Jaehning JA, Kim YJ, Kuras L, Leutz A, Lis JT, Meisterernest M, Naar AM, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Mol Cell. 2004 Jun 04; 14(5):553-7. PMID: 15175151.
    View in: PubMed
  8. Yang F, DeBeaumont R, Zhou S, Näär AM. The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2339-44. PMID: 14983011; PMCID: PMC356952.
  9. Kato Y, Habas R, Katsuyama Y, Näär AM, He X. A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. Nature. 2002 Aug 08; 418(6898):641-6. PMID: 12167862.
    View in: PubMed
  10. Näär AM, Taatjes DJ, Zhai W, Nogales E, Tjian R. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation. Genes Dev. 2002 Jun 01; 16(11):1339-44. PMID: 12050112; PMCID: PMC186316.
  11. Taatjes DJ, Näär AM, Andel F, Nogales E, Tjian R. Structure, function, and activator-induced conformations of the CRSP coactivator. Science. 2002 Feb 08; 295(5557):1058-62. PMID: 11834832.
    View in: PubMed
  12. Ross JF, Näär A, Cam H, Gregory R, Dynlacht BD. Active repression and E2F inhibition by pRB are biochemically distinguishable. Genes Dev. 2001 Feb 15; 15(4):392-7. PMID: 11230147; PMCID: PMC312635.
  13. Näär AM, Lemon BD, Tjian R. Transcriptional coactivator complexes. Annu Rev Biochem. 2001; 70:475-501. PMID: 11395415.
    View in: PubMed
  14. Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R. Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature. 1999 Apr 29; 398(6730):828-32. PMID: 10235267.
    View in: PubMed
  15. Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP. Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex. Nature. 1999 Apr 29; 398(6730):824-8. PMID: 10235266.
    View in: PubMed
  16. Näär AM, Beaurang PA, Robinson KM, Oliner JD, Avizonis D, Scheek S, Zwicker J, Kadonaga JT, Tjian R. Chromatin, TAFs, and a novel multiprotein coactivator are required for synergistic activation by Sp1 and SREBP-1a in vitro. Genes Dev. 1998 Oct 01; 12(19):3020-31. PMID: 9765204; PMCID: PMC317191.
  17. Näär AM, Ryu S, Tjian R. Cofactor requirements for transcriptional activation by Sp1. Cold Spring Harb Symp Quant Biol. 1998; 63:189-99. PMID: 10384283.
    View in: PubMed
  18. Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass CK, et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature. 1995 Oct 05; 377(6548):397-404. PMID: 7566114.
    View in: PubMed
  19. Lipkin SM, Näär AM, Kalla KA, Sack RA, Rosenfeld MG. Identification of a novel zinc finger protein binding a conserved element critical for Pit-1-dependent growth hormone gene expression. Genes Dev. 1993 Sep; 7(9):1674-87. PMID: 8370519.
    View in: PubMed
  20. Kurokawa R, Yu VC, Näär A, Kyakumoto S, Han Z, Silverman S, Rosenfeld MG, Glass CK. Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers. Genes Dev. 1993 Jul; 7(7B):1423-35. PMID: 8392479.
    View in: PubMed
  21. Yu VC, Näär AM, Rosenfeld MG. Transcriptional regulation by the nuclear receptor superfamily. Curr Opin Biotechnol. 1992 Dec; 3(6):597-602. PMID: 1369415.
    View in: PubMed
  22. Yu VC, Delsert C, Andersen B, Holloway JM, Devary OV, Näär AM, Kim SY, Boutin JM, Glass CK, Rosenfeld MG. RXR beta: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell. 1991 Dec 20; 67(6):1251-66. PMID: 1662118.
    View in: PubMed
  23. Näär AM, Boutin JM, Lipkin SM, Yu VC, Holloway JM, Glass CK, Rosenfeld MG. The orientation and spacing of core DNA-binding motifs dictate selective transcriptional responses to three nuclear receptors. Cell. 1991 Jun 28; 65(7):1267-79. PMID: 1648451.
    View in: PubMed
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