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Antonios O. Aliprantis, M.D., Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AG046257 (CHARLES, JULIA F.) Sep 30, 2013 - Jun 30, 2018
    NIH/NIA
    Myeloid precursors and the microbiome in the osteoimmunology of aging
    Role: Co-Principal Investigator
  2. R01AR060363 (ALIPRANTIS, ANTONIOS O) Aug 1, 2011 - Jul 31, 2016
    NIH/NIAMS
    Regulation of osteoclast biology by anion exchanger SLC4A2 in mouse and human sys
    Role: Principal Investigator
  3. K08AR054859 (ALIPRANTIS, ANTONIOS O) Jul 1, 2008 - Apr 30, 2013
    NIH/NIAMS
    Novel regulatory mechanisms of the osteoclast transcriptional program
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM. Author Correction: Towards an arthritis flare-responsive drug delivery system. Nat Commun. 2018 05 11; 9(1):1954. PMID: 29752435.
    View in: PubMed
  2. Joshi N, Yan J, Levy S, Bhagchandani S, Slaughter KV, Sherman NE, Amirault J, Wang Y, Riegel L, He X, Rui TS, Valic M, Vemula PK, Miranda OR, Levy O, Gravallese EM, Aliprantis AO, Ermann J, Karp JM. Towards an arthritis flare-responsive drug delivery system. Nat Commun. 2018 04 03; 9(1):1275. PMID: 29615615.
    View in: PubMed
  3. Xiong Y, Berrueta L, Urso K, Olenich S, Muskaj I, Badger GJ, Aliprantis A, Lafyatis R, Langevin HM. Stretching Reduces Skin Thickness and Improves Subcutaneous Tissue Mobility in a Murine Model of Systemic Sclerosis. Front Immunol. 2017; 8:124. PMID: 28261202.
    View in: PubMed
  4. O'Brien W, Fissel BM, Maeda Y, Yan J, Ge X, Gravallese EM, Aliprantis AO, Charles JF. RANK-Independent Osteoclast Formation and Bone Erosion in Inflammatory Arthritis. Arthritis Rheumatol. 2016 12; 68(12):2889-2900. PMID: 27563728.
    View in: PubMed
  5. Yan J, Herzog JW, Tsang K, Brennan CA, Bower MA, Garrett WS, Sartor BR, Aliprantis AO, Charles JF. Gut microbiota induce IGF-1 and promote bone formation and growth. Proc Natl Acad Sci U S A. 2016 11 22; 113(47):E7554-E7563. PMID: 27821775.
    View in: PubMed
  6. Urso K, Alvarez D, Cremasco V, Tsang K, Grauel A, Lafyatis R, von Andrian UH, Ermann J, Aliprantis AO. IL4RA on lymphatic endothelial cells promotes T cell egress during sclerodermatous graft versus host disease. JCI Insight. 2016 Aug 04; 1(12). PMID: 27547823.
    View in: PubMed
  7. Sargent JL, Li Z, Aliprantis AO, Greenblatt M, Lemaire R, Wu MH, Wei J, Taroni J, Harris A, Long KB, Burgwin C, Artlett CM, Blankenhorn EP, Lafyatis R, Varga J, Clark SH, Whitfield ML. Identification of Optimal Mouse Models of Systemic Sclerosis by Interspecies Comparative Genomics. Arthritis Rheumatol. 2016 08; 68(8):2003-15. PMID: 26945694.
    View in: PubMed
  8. Ge X, Ritter SY, Tsang K, Shi R, Takei K, Aliprantis AO. Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1. PLoS One. 2016; 11(7):e0159157. PMID: 27415616; PMCID: PMC4945026.
  9. Urso K, Charles JF, Shull GE, Aliprantis AO, Balestrieri B. Anion Exchanger 2 Regulates Dectin-1-Dependent Phagocytosis and Killing of Candida albicans. PLoS One. 2016; 11(7):e0158893. PMID: 27391897; PMCID: PMC4938408.
  10. Ge X, Tsang K, He L, Garcia RA, Ermann J, Mizoguchi F, Zhang M, Zhou B, Zhou B, Aliprantis AO. NFAT restricts osteochondroma formation from entheseal progenitors. JCI Insight. 2016 Apr; 1(4):e86254. PMID: 27158674.
    View in: PubMed
  11. Vines JB, Aliprantis AO, Gomoll AH, Farr J. Cryopreserved Amniotic Suspension for the Treatment of Knee Osteoarthritis. J Knee Surg. 2016 Aug; 29(6):443-50. PMID: 26683979.
    View in: PubMed
  12. Charles JF, Ermann J, Aliprantis AO. The intestinal microbiome and skeletal fitness: Connecting bugs and bones. Clin Immunol. 2015 Aug; 159(2):163-9. PMID: 25840106.
    View in: PubMed
  13. Ritter SY, Collins J, Krastins B, Sarracino D, Lopez M, Losina E, Aliprantis AO. Mass spectrometry assays of plasma biomarkers to predict radiographic progression of knee osteoarthritis. Arthritis Res Ther. 2014 Oct 07; 16(5):456. PMID: 25287745; PMCID: PMC4207325.
  14. Charles JF, Aliprantis AO. Osteoclasts: more than 'bone eaters'. Trends Mol Med. 2014 Aug; 20(8):449-59. PMID: 25008556.
    View in: PubMed
  15. Greenblatt MB, Ritter SY, Wright J, Tsang K, Hu D, Glimcher LH, Aliprantis AO. NFATc1 and NFATc2 repress spontaneous osteoarthritis. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):19914-9. PMID: 24248346; PMCID: PMC3856808.
  16. Ritter SY, Subbaiah R, Bebek G, Crish J, Scanzello CR, Krastins B, Sarracino D, Lopez MF, Crow MK, Aigner T, Goldring MB, Goldring SR, Lee DM, Gobezie R, Aliprantis AO. Proteomic analysis of synovial fluid from the osteoarthritic knee: comparison with transcriptome analyses of joint tissues. Arthritis Rheum. 2013 Apr; 65(4):981-92. PMID: 23400684; PMCID: PMC3618606.
  17. Coury F, Zenger S, Stewart AK, Stephens S, Neff L, Tsang K, Shull GE, Alper SL, Baron R, Aliprantis AO. SLC4A2-mediated Cl-/HCO3- exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts. Proc Natl Acad Sci U S A. 2013 Feb 05; 110(6):2163-8. PMID: 23341620; PMCID: PMC3568349.
  18. Greenblatt MB, Aliprantis AO. The immune pathogenesis of scleroderma: context is everything. Curr Rheumatol Rep. 2013 Jan; 15(1):297. PMID: 23288576; PMCID: PMC3539168.
  19. Charles JF, Hsu LY, Niemi EC, Weiss A, Aliprantis AO, Nakamura MC. Inflammatory arthritis increases mouse osteoclast precursors with myeloid suppressor function. J Clin Invest. 2012 Dec; 122(12):4592-605. PMID: 23114597; PMCID: PMC3533532.
  20. Greenblatt MB, Vrbanac V, Vbranac V, Tivey T, Tsang K, Tager AM, Aliprantis AO. Graft versus host disease in the bone marrow, liver and thymus humanized mouse model. PLoS One. 2012; 7(9):e44664. PMID: 22957096; PMCID: PMC3434179.
  21. Charles JF, Coury F, Sulyanto R, Sitara D, Wu J, Brady N, Tsang K, Sigrist K, Tollefsen DM, He L, Storm D, Aliprantis AO. The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. Bone. 2012 Nov; 51(5):902-12. PMID: 22985540; PMCID: PMC3457000.
  22. Wein MN, Jones DC, Shim JH, Aliprantis AO, Sulyanto R, Lazarevic V, Poliachik SL, Gross TS, Glimcher LH. Control of bone resorption in mice by Schnurri-3. Proc Natl Acad Sci U S A. 2012 May 22; 109(21):8173-8. PMID: 22573816; PMCID: PMC3361406.
  23. Greenblatt MB, Sargent JL, Farina G, Tsang K, Lafyatis R, Glimcher LH, Whitfield ML, Aliprantis AO. Interspecies comparison of human and murine scleroderma reveals IL-13 and CCL2 as disease subset-specific targets. Am J Pathol. 2012 Mar; 180(3):1080-94. PMID: 22245215; PMCID: PMC3349888.
  24. Aliprantis AO, Stolina M, Kostenuik PJ, Poliachik SL, Warner SE, Bain SD, Gross TS. Transient muscle paralysis degrades bone via rapid osteoclastogenesis. FASEB J. 2012 Mar; 26(3):1110-8. PMID: 22125315; PMCID: PMC3289507.
  25. Broen JC, Dieude P, Vonk MC, Beretta L, Carmona FD, Herrick A, Worthington J, Hunzelmann N, Riemekasten G, Kiener H, Scorza R, Simeon CP, Fonollosa V, Carreira P, Ortego-Centeno N, Gonzalez-Gay MA, Airo' P, Coenen MJ, Tsang K, Aliprantis AO, Martin J, Allanore Y, Radstake TR. Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression. J Rheumatol. 2012 Jan; 39(1):112-8. PMID: 22045834.
    View in: PubMed
  26. Jones D, Glimcher LH, Aliprantis AO. Osteoimmunology at the nexus of arthritis, osteoporosis, cancer, and infection. J Clin Invest. 2011 Jul; 121(7):2534-42. PMID: 21737885; PMCID: PMC3223839.
  27. Schramek D, Leibbrandt A, Sigl V, Kenner L, Pospisilik JA, Lee HJ, Hanada R, Joshi PA, Aliprantis A, Glimcher L, Pasparakis M, Khokha R, Ormandy CJ, Widschwendter M, Schett G, Penninger JM. Osteoclast differentiation factor RANKL controls development of progestin-driven mammary cancer. Nature. 2010 Nov 04; 468(7320):98-102. PMID: 20881962; PMCID: PMC3084017.
  28. Greenblatt MB, Aliprantis A, Hu B, Glimcher LH. Calcineurin regulates innate antifungal immunity in neutrophils. J Exp Med. 2010 May 10; 207(5):923-31. PMID: 20421389; PMCID: PMC2867274.
  29. Aliprantis AO, Glimcher LH. NFATc1 in inflammatory and musculoskeletal conditions. Adv Exp Med Biol. 2010; 658:69-75. PMID: 19950017.
    View in: PubMed
  30. Sitara D, Aliprantis AO. Transcriptional regulation of bone and joint remodeling by NFAT. Immunol Rev. 2010 Jan; 233(1):286-300. PMID: 20193006; PMCID: PMC2904911.
  31. Wu J, Glimcher LH, Aliprantis AO. HCO3-/Cl- anion exchanger SLC4A2 is required for proper osteoclast differentiation and function. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):16934-9. PMID: 18971331; PMCID: PMC2579356.
  32. Aliprantis AO, Ueki Y, Sulyanto R, Park A, Sigrist KS, Sharma SM, Ostrowski MC, Olsen BR, Glimcher LH. NFATc1 in mice represses osteoprotegerin during osteoclastogenesis and dissociates systemic osteopenia from inflammation in cherubism. J Clin Invest. 2008 Nov; 118(11):3775-89. PMID: 18846253.
    View in: PubMed
  33. Horsley V, Aliprantis AO, Polak L, Glimcher LH, Fuchs E. NFATc1 balances quiescence and proliferation of skin stem cells. Cell. 2008 Jan 25; 132(2):299-310. PMID: 18243104; PMCID: PMC2546702.
  34. Aliprantis AO, Wang J, Fathman JW, Lemaire R, Dorfman DM, Lafyatis R, Glimcher LH. Transcription factor T-bet regulates skin sclerosis through its function in innate immunity and via IL-13. Proc Natl Acad Sci U S A. 2007 Feb 20; 104(8):2827-30. PMID: 17307869; PMCID: PMC1815266.
  35. Phillips K, Aliprantis A, Coblyn J. Strategies for the prevention and treatment of osteoporosis in patients with rheumatoid arthritis. Drugs Aging. 2006; 23(10):773-9. PMID: 17067181.
    View in: PubMed
  36. Aliprantis AO, Weiss DS, Radolf JD, Zychlinsky A. Release of Toll-like receptor-2-activating bacterial lipoproteins in Shigella flexneri culture supernatants. Infect Immun. 2001 Oct; 69(10):6248-55. PMID: 11553567; PMCID: PMC98758.
  37. Aliprantis AO, Weiss DS, Zychlinsky A. Toll-like receptor-2 transduces signals for NF-kappa B activation, apoptosis and reactive oxygen species production. J Endotoxin Res. 2001; 7(4):287-91. PMID: 11717583.
    View in: PubMed
  38. Aliprantis AO, Yang RB, Weiss DS, Godowski P, Zychlinsky A. The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J. 2000 Jul 03; 19(13):3325-36. PMID: 10880445; PMCID: PMC313930.
  39. Aliprantis AO, Yang RB, Mark MR, Suggett S, Devaux B, Radolf JD, Klimpel GR, Godowski P, Zychlinsky A. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2. Science. 1999 Jul 30; 285(5428):736-9. PMID: 10426996.
    View in: PubMed
  40. Moss JE, Aliprantis AO, Zychlinsky A. The regulation of apoptosis by microbial pathogens. Int Rev Cytol. 1999; 187:203-59. PMID: 10212981.
    View in: PubMed
  41. Aliprantis AO, Diez-Roux G, Mulder LC, Zychlinsky A, Lang RA. Do macrophages kill through apoptosis? Immunol Today. 1996 Dec; 17(12):573-6. PMID: 8991289.
    View in: PubMed
  42. Zychlinsky A, Thirumalai K, Arondel J, Cantey JR, Aliprantis AO, Sansonetti PJ. In vivo apoptosis in Shigella flexneri infections. Infect Immun. 1996 Dec; 64(12):5357-65. PMID: 8945588; PMCID: PMC174530.
  43. Gerace L, Aliprantis A, Russell M, Allison DB, Buhl KM, Wang J, Wang ZM, Pierson RN, Heymsfield SB. Skeletal differences between black and white men and their relevance to body composition estimates. Am J Hum Biol. 1994; 6(2):255-262. PMID: 28548276.
    View in: PubMed
  44. Heymsfield SB, Lichtman S, Baumgartner RN, Wang J, Kamen Y, Aliprantis A, Pierson RN. Body composition of humans: comparison of two improved four-compartment models that differ in expense, technical complexity, and radiation exposure. Am J Clin Nutr. 1990 Jul; 52(1):52-8. PMID: 2360552.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.