Harvard Catalyst Profiles

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Elda Arrigoni, Ph.D.

Other Positions

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01NS091126 (ARRIGONI, ELDA) Apr 1, 2015 - Mar 31, 2021
    Basal forebrain hypothalamic networks supporting wakefulness
    Role: Principal Investigator
  2. R21NS082854 (ARRIGONI, ELDA) Sep 15, 2013 - Aug 31, 2016
    Basal Forebrain Corticopetal GABAergic Neurons and Cortical Arousal
    Role: Principal Investigator
  3. P01HL095491 (SAPER, CLIFFORD B) Apr 1, 2009 - May 31, 2021
    Mechanisms of Arousal in Sleep Apnea
    Role: Co-Principal Investigator
  4. R01NS061863 (ARRIGONI, ELDA) Jan 1, 2009 - Dec 31, 2014
    Pontine Control of REM Atonia
    Role: Principal Investigator
  5. P50HL060292 (SAPER, CLIFFORD) Sep 1, 1998 - Aug 31, 2008
    Harvard Center on Sleep Neurobiology and Sleep Apnea (SCOR)
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kroeger D, Thundercliffe J, Phung A, De Luca R, Geraci C, Bragg S, McCafferty KJ, Bandaru SS, Arrigoni E, Scammell TE. Glutamatergic pedunculopontine tegmental neurons control wakefulness and locomotion via distinct axonal projections. Sleep. 2022 Dec 12; 45(12). PMID: 36170177; PMCID: PMC9742893.
    Citations:    Fields:    Translation:AnimalsCells
  2. De Luca R, Nardone S, Grace KP, Venner A, Cristofolini M, Bandaru SS, Sohn LT, Kong D, Mochizuki T, Viberti B, Zhu L, Zito A, Scammell TE, Saper CB, Lowell BB, Fuller PM, Arrigoni E. Orexin neurons inhibit sleep to promote arousal. Nat Commun. 2022 07 18; 13(1):4163. PMID: 35851580; PMCID: PMC9293990.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Arrigoni E, Fuller PM. The Sleep-Promoting Ventrolateral Preoptic Nucleus: What Have We Learned over the Past 25 Years? Int J Mol Sci. 2022 Mar 08; 23(6). PMID: 35328326; PMCID: PMC8954377.
    Citations:    Fields:    Translation:Cells
  4. Arrigoni E, Fuller PM. Addicted to dreaming. Science. 2022 03 04; 375(6584):972-973. PMID: 35239395.
    Citations:    Fields:    
  5. Arrigoni E, Fuller PM. The Role of the Central Histaminergic System in Behavioral State Control. Curr Top Behav Neurosci. 2022; 59:447-468. PMID: 34595740.
    Citations:    Fields:    
  6. Todd WD, Venner A, Anaclet C, Broadhurst RY, De Luca R, Bandaru SS, Issokson L, Hablitz LM, Cravetchi O, Arrigoni E, Campbell JN, Allen CN, Olson DP, Fuller PM. Suprachiasmatic VIP neurons are required for normal circadian rhythmicity and comprised of molecularly distinct subpopulations. Nat Commun. 2020 09 02; 11(1):4410. PMID: 32879310; PMCID: PMC7468160.
    Citations: 23     Fields:    Translation:AnimalsCells
  7. Kaur S, De Luca R, Khanday MA, Bandaru SS, Thomas RC, Broadhurst RY, Venner A, Todd WD, Fuller PM, Arrigoni E, Saper CB. Role of serotonergic dorsal raphe neurons in hypercapnia-induced arousals. Nat Commun. 2020 06 02; 11(1):2769. PMID: 32488015.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Venner A, De Luca R, Sohn LT, Bandaru SS, Verstegen AMJ, Arrigoni E, Fuller PM. An Inhibitory Lateral Hypothalamic-Preoptic Circuit Mediates Rapid Arousals from Sleep. Curr Biol. 2019 12 16; 29(24):4155-4168.e5. PMID: 31761703.
    Citations: 12     Fields:    Translation:AnimalsCells
  9. Venner A, Mochizuki T, De Luca R, Anaclet C, Scammell TE, Saper CB, Arrigoni E, Fuller PM. Reassessing the Role of Histaminergic Tuberomammillary Neurons in Arousal Control. J Neurosci. 2019 11 06; 39(45):8929-8939. PMID: 31548232.
    Citations: 9     Fields:    Translation:AnimalsCells
  10. Zhu L, Chamberlin NL, Arrigoni E. Muscarinic Inhibition of Hypoglossal Motoneurons: Possible Implications for Upper Airway Muscle Hypotonia during REM Sleep. J Neurosci. 2019 10 02; 39(40):7910-7919. PMID: 31420456; PMCID: PMC6774407.
    Citations: 3     Fields:    Translation:AnimalsCells
  11. Verstegen AMJ, Klymko N, Zhu L, Mathai JC, Kobayashi R, Venner A, Ross RA, VanderHorst VG, Arrigoni E, Geerling JC, Zeidel ML. Non-Crh Glutamatergic Neurons in Barrington's Nucleus Control Micturition via Glutamatergic Afferents from the Midbrain and Hypothalamus. Curr Biol. 2019 09 09; 29(17):2775-2789.e7. PMID: 31422881.
    Citations: 13     Fields:    Translation:AnimalsCells
  12. Arrigoni E, Chee MJS, Fuller PM. To eat or to sleep: That is a lateral hypothalamic question. Neuropharmacology. 2019 08; 154:34-49. PMID: 30503993.
    Citations: 32     Fields:    Translation:HumansAnimals
  13. Kroeger D, Absi G, Gagliardi C, Bandaru SS, Madara JC, Ferrari LL, Arrigoni E, Münzberg H, Scammell TE, Saper CB, Vetrivelan R. Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice. Nat Commun. 2018 10 08; 9(1):4129. PMID: 30297727.
    Citations: 58     Fields:    Translation:AnimalsCells
  14. Machado NLS, Abbott SBG, Resch JM, Zhu L, Arrigoni E, Lowell BB, Fuller PM, Fontes MAP, Saper CB. A Glutamatergic Hypothalamomedullary Circuit Mediates Thermogenesis, but Not Heat Conservation, during Stress-Induced Hyperthermia. Curr Biol. 2018 07 23; 28(14):2291-2301.e5. PMID: 30017482.
    Citations: 23     Fields:    Translation:AnimalsCells
  15. Anaclet C, De Luca R, Venner A, Malyshevskaya O, Lazarus M, Arrigoni E, Fuller PM. Genetic Activation, Inactivation, and Deletion Reveal a Limited And Nuanced Role for Somatostatin-Containing Basal Forebrain Neurons in Behavioral State Control. J Neurosci. 2018 05 30; 38(22):5168-5181. PMID: 29735555; PMCID: PMC5977448.
    Citations: 9     Fields:    Translation:AnimalsCells
  16. Ferrari LL, Park D, Zhu L, Palmer MR, Broadhurst RY, Arrigoni E. Regulation of Lateral Hypothalamic Orexin Activity by Local GABAergic Neurons. J Neurosci. 2018 02 07; 38(6):1588-1599. PMID: 29311142; PMCID: PMC5815356.
    Citations: 20     Fields:    Translation:AnimalsCells
  17. Pedersen NP, Ferrari L, Venner A, Wang JL, Abbott SBG, Vujovic N, Arrigoni E, Saper CB, Fuller PM. Supramammillary glutamate neurons are a key node of the arousal system. Nat Commun. 2017 11 10; 8(1):1405. PMID: 29123082.
    Citations: 50     Fields:    Translation:AnimalsCells
  18. Kaur S, Wang JL, Ferrari L, Thankachan S, Kroeger D, Venner A, Lazarus M, Wellman A, Arrigoni E, Fuller PM, Saper CB. A Genetically Defined Circuit for Arousal from Sleep during Hypercapnia. Neuron. 2017 Dec 06; 96(5):1153-1167.e5. PMID: 29103805.
    Citations: 46     Fields:    Translation:AnimalsCells
  19. Agostinelli LJ, Ferrari LL, Mahoney CE, Mochizuki T, Lowell BB, Arrigoni E, Scammell TE. Descending projections from the basal forebrain to the orexin neurons in mice. J Comp Neurol. 2017 May 01; 525(7):1668-1684. PMID: 27997037; PMCID: PMC5806522.
    Citations: 13     Fields:    Translation:AnimalsCells
  20. Scammell TE, Arrigoni E, Lipton JO. Neural Circuitry of Wakefulness and Sleep. Neuron. 2017 Feb 22; 93(4):747-765. PMID: 28231463.
    Citations: 213     Fields:    Translation:HumansAnimalsCells
  21. Kroeger D, Ferrari LL, Petit G, Mahoney CE, Fuller PM, Arrigoni E, Scammell TE. Cholinergic, Glutamatergic, and GABAergic Neurons of the Pedunculopontine Tegmental Nucleus Have Distinct Effects on Sleep/Wake Behavior in Mice. J Neurosci. 2017 02 01; 37(5):1352-1366. PMID: 28039375; PMCID: PMC5296799.
    Citations: 57     Fields:    Translation:AnimalsCells
  22. Vetrivelan R, Kong D, Ferrari LL, Arrigoni E, Madara JC, Bandaru SS, Lowell BB, Lu J, Saper CB. Melanin-concentrating hormone neurons specifically promote rapid eye movement sleep in mice. Neuroscience. 2016 Nov 12; 336:102-113. PMID: 27595887.
    Citations: 34     Fields:    Translation:AnimalsCells
  23. Arrigoni E, Chen MC, Fuller PM. The anatomical, cellular and synaptic basis of motor atonia during rapid eye movement sleep. J Physiol. 2016 10 01; 594(19):5391-414. PMID: 27060683; PMCID: PMC5043043.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  24. Ferrari LL, Agostinelli LJ, Krashes MJ, Lowell BB, Scammell TE, Arrigoni E. Dynorphin inhibits basal forebrain cholinergic neurons by pre- and postsynaptic mechanisms. J Physiol. 2016 Feb 15; 594(4):1069-85. PMID: 26613645; PMCID: PMC4753266.
    Citations: 10     Fields:    Translation:AnimalsCells
  25. Anaclet C, Pedersen NP, Ferrari LL, Venner A, Bass CE, Arrigoni E, Fuller PM. Basal forebrain control of wakefulness and cortical rhythms. Nat Commun. 2015 Nov 03; 6:8744. PMID: 26524973.
    Citations: 103     Fields:    Translation:AnimalsCells
  26. Chee MJ, Arrigoni E, Maratos-Flier E. Melanin-concentrating hormone neurons release glutamate for feedforward inhibition of the lateral septum. J Neurosci. 2015 Feb 25; 35(8):3644-51. PMID: 25716862; PMCID: PMC6605558.
    Citations: 41     Fields:    Translation:AnimalsCells
  27. Chen MC, Ferrari L, Sacchet MD, Foland-Ross LC, Qiu MH, Gotlib IH, Fuller PM, Arrigoni E, Lu J. Identification of a direct GABAergic pallidocortical pathway in rodents. Eur J Neurosci. 2015 Mar; 41(6):748-59. PMID: 25581560.
    Citations: 31     Fields:    Translation:AnimalsCells
  28. Anaclet C, Ferrari L, Arrigoni E, Bass CE, Saper CB, Lu J, Fuller PM. Corrigendum: The GABAergic parafacial zone is a medullary slow wave sleep-promoting center. Nat Neurosci. 2014 Nov 21; 17(12):1841. PMID: 25413100.
  29. Anaclet C, Ferrari L, Arrigoni E, Bass CE, Saper CB, Lu J, Fuller PM. The GABAergic parafacial zone is a medullary slow wave sleep-promoting center. Nat Neurosci. 2014 Sep; 17(9):1217-24. PMID: 25129078.
    Citations: 101     Fields:    Translation:AnimalsCells
  30. Arrigoni E, Saper CB. What optogenetic stimulation is telling us (and failing to tell us) about fast neurotransmitters and neuromodulators in brain circuits for wake-sleep regulation. Curr Opin Neurobiol. 2014 Dec; 29:165-71. PMID: 25064179.
    Citations: 27     Fields:    Translation:HumansCells
  31. Williams RH, Chee MJ, Kroeger D, Ferrari LL, Maratos-Flier E, Scammell TE, Arrigoni E. Optogenetic-mediated release of histamine reveals distal and autoregulatory mechanisms for controlling arousal. J Neurosci. 2014 Apr 23; 34(17):6023-9. PMID: 24760861.
    Citations: 43     Fields:    Translation:AnimalsCells
  32. Weng FJ, Williams RH, Hawryluk JM, Lu J, Scammell TE, Saper CB, Arrigoni E. Carbachol excites sublaterodorsal nucleus neurons projecting to the spinal cord. J Physiol. 2014 Apr 01; 592(7):1601-17. PMID: 24344163.
    Citations: 15     Fields:    Translation:AnimalsCells
  33. Oishi Y, Williams RH, Agostinelli L, Arrigoni E, Fuller PM, Mochizuki T, Saper CB, Scammell TE. Role of the medial prefrontal cortex in cataplexy. J Neurosci. 2013 Jun 05; 33(23):9743-51. PMID: 23739971.
    Citations: 38     Fields:    Translation:Animals
  34. Hawryluk JM, Ferrari LL, Keating SA, Arrigoni E. Adenosine inhibits glutamatergic input to basal forebrain cholinergic neurons. J Neurophysiol. 2012 May; 107(10):2769-81. PMID: 22357797.
    Citations: 17     Fields:    Translation:AnimalsCells
  35. Mochizuki T, Arrigoni E, Marcus JN, Clark EL, Yamamoto M, Honer M, Borroni E, Lowell BB, Elmquist JK, Scammell TE. Orexin receptor 2 expression in the posterior hypothalamus rescues sleepiness in narcoleptic mice. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4471-6. PMID: 21368172.
    Citations: 58     Fields:    Translation:AnimalsCells
  36. Arrigoni E, Lu J, Vetrivelan R, Saper CB. Long-term synaptic plasticity is impaired in rats with lesions of the ventrolateral preoptic nucleus. Eur J Neurosci. 2009 Dec 03; 30(11):2112-20. PMID: 20128848.
    Citations: 8     Fields:    Translation:AnimalsCells
  37. Arrigoni E, Mochizuki T, Scammell TE. Activation of the basal forebrain by the orexin/hypocretin neurones. Acta Physiol (Oxf). 2010 Mar; 198(3):223-35. PMID: 19723027.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  38. Arrigoni E, Rosenberg PA. Nitric oxide-induced adenosine inhibition of hippocampal synaptic transmission depends on adenosine kinase inhibition and is cyclic GMP independent. Eur J Neurosci. 2006 Nov; 24(9):2471-80. PMID: 17100836.
    Citations: 6     Fields:    Translation:AnimalsCells
  39. Tartar JL, Ward CP, McKenna JT, Thakkar M, Arrigoni E, McCarley RW, Brown RE, Strecker RE. Hippocampal synaptic plasticity and spatial learning are impaired in a rat model of sleep fragmentation. Eur J Neurosci. 2006 May; 23(10):2739-48. PMID: 16817877; PMCID: PMC3607950.
    Citations: 86     Fields:    Translation:Animals
  40. Arrigoni E, Chamberlin NL, Saper CB, McCarley RW. Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro. Neuroscience. 2006 Jun 30; 140(2):403-13. PMID: 16542780.
    Citations: 38     Fields:    Translation:AnimalsCells
  41. Arrigoni E, Crocker AJ, Saper CB, Greene RW, Scammell TE. Deletion of presynaptic adenosine A1 receptors impairs the recovery of synaptic transmission after hypoxia. Neuroscience. 2005; 132(3):575-80. PMID: 15837119.
    Citations: 12     Fields:    Translation:AnimalsCells
  42. Arrigoni E, Greene RW. Schaffer collateral and perforant path inputs activate different subtypes of NMDA receptors on the same CA1 pyramidal cell. Br J Pharmacol. 2004 May; 142(2):317-22. PMID: 15155538; PMCID: PMC1574942.
    Citations: 28     Fields:    Translation:AnimalsCells
  43. Scammell TE, Arrigoni E, Thompson MA, Ronan PJ, Saper CB, Greene RW. Focal deletion of the adenosine A1 receptor in adult mice using an adeno-associated viral vector. J Neurosci. 2003 Jul 02; 23(13):5762-70. PMID: 12843280; PMCID: PMC6741251.
    Citations: 46     Fields:    Translation:AnimalsCells
  44. Chamberlin NL, Arrigoni E, Chou TC, Scammell TE, Greene RW, Saper CB. Effects of adenosine on gabaergic synaptic inputs to identified ventrolateral preoptic neurons. Neuroscience. 2003; 119(4):913-8. PMID: 12831851.
    Citations: 39     Fields:    Translation:AnimalsCells
  45. Basheer R, Arrigoni E, Thatte HS, Greene RW, Ambudkar IS, McCarley RW. Adenosine induces inositol 1,4,5-trisphosphate receptor-mediated mobilization of intracellular calcium stores in basal forebrain cholinergic neurons. J Neurosci. 2002 Sep 01; 22(17):7680-6. PMID: 12196591; PMCID: PMC6758010.
    Citations: 17     Fields:    Translation:AnimalsCells
  46. Formenti A, De Simoni A, Arrigoni E, Martina M. Changes in extracellular Ca2+ can affect the pattern of discharge in rat thalamic neurons. J Physiol. 2001 Aug 15; 535(Pt 1):33-45. PMID: 11507156; PMCID: PMC2278774.
    Citations: 14     Fields:    Translation:AnimalsCells
  47. Arrigoni E, Rainnie DG, McCarley RW, Greene RW. Adenosine-mediated presynaptic modulation of glutamatergic transmission in the laterodorsal tegmentum. J Neurosci. 2001 Feb 01; 21(3):1076-85. PMID: 11157094; PMCID: PMC6762335.
    Citations: 23     Fields:    Translation:AnimalsCells
  48. Formenti A, Arrigoni E, Martina M, Taverna S, Avanzini G, Mancia M. Calcium influx in rat thalamic relay neurons through voltage-dependent calcium channels is inhibited by enkephalin. Neurosci Lett. 1995 Dec 01; 201(1):21-4. PMID: 8830303.
    Citations: 3     Fields:    Translation:AnimalsCells
  49. Formenti A, Arrigoni E, Mancia M. Low-voltage activated calcium channels are differently affected by nimodipine. Neuroreport. 1993 Nov 18; 5(2):145-7. PMID: 8111001.
    Citations: 2     Fields:    Translation:AnimalsCells
  50. Formenti A, Arrigoni E, Mancia M. Two distinct modulatory effects on calcium channels in adult rat sensory neurons. Biophys J. 1993 Apr; 64(4):1029-37. PMID: 8388263; PMCID: PMC1262420.
    Citations: 9     Fields:    Translation:AnimalsCells
  51. Arrigoni E, Benzi G, Ferrara A. Effect of tetracyclines and 4-epiderivatives on the ureter. Br J Pharmacol. 1972 Apr; 44(4):788-93. PMID: 4625269; PMCID: PMC1665986.
    Citations:    Fields:    Translation:Animals
  52. Benzi G, Arrigoni E, Sanguinetti L. Antibiotics and ureter. 3. Chloramphenicol. Arch Int Pharmacodyn Ther. 1970 Jun; 185(2):329-36. PMID: 5473793.
    Citations:    Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.