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Last Name

profileGalit Lahav, PH.D.

TitleProfessor of Systems Biology
InstitutionHarvard Medical School
DepartmentSystems Biology
AddressHarvard Medical School
Systems Biology, Alper 555
200 Longwood Ave
Boston MA 02115
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Collapse Mentoring 
Collapse completed student projects
Pharmacological Perturbations of the p53 Pathway: p53-Chk2 Feedback
Summer, 06/01/06 - 08/22/06

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01GM116864     (LAHAV, GALIT)Feb 1, 2017 - Dec 31, 2020
Dynamics of Cellular Senescence in Single Cells
Role: Principal Investigator

R01GM083303     (LAHAV, GALIT)Mar 1, 2008 - May 31, 2021
Dynamics of Signaling Pathways: Mechanism and Function
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Reyes J, Lahav G. Leveraging and coping with uncertainty in the response of individual cells to therapy. Curr Opin Biotechnol. 2017 Dec 27; 51:109-115. PMID: 29288931.
    View in: PubMed
  2. Stewart-Ornstein J, Cheng HWJ, Lahav G. Conservation and Divergence of p53 Oscillation Dynamics across Species. Cell Syst. 2017 Oct 25; 5(4):410-417.e4. PMID: 29055670.
    View in: PubMed
  3. Hafner A, Stewart-Ornstein J, Purvis JE, Forrester WC, Bulyk ML, Lahav G. p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics. Nat Struct Mol Biol. 2017 Oct; 24(10):840-847. PMID: 28825732.
    View in: PubMed
  4. Oppenheim A, Lahav G. The puzzling interplay between p53 and Sp1. Aging (Albany NY). 2017 May 09; 9(5):1355-1356. PMID: 28490691.
    View in: PubMed
  5. Stewart-Ornstein J, Lahav G. p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM. Sci Signal. 2017 Apr 25; 10(476). PMID: 28442631.
    View in: PubMed
  6. Stewart-Ornstein J, Lahav G. Integrating genomic information and signaling dynamics for efficient cancer therapy. Curr Opin Syst Biol. 2017 Feb; 1:38-43. PMID: 28944311.
    View in: PubMed
  7. Drayman N, Ben-Nun-Shaul O, Butin-Israeli V, Srivastava R, Rubinstein AM, Mock CS, Elyada E, Ben-Neriah Y, Lahav G, Oppenheim A. p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression. Oncotarget. 2016 Aug 16; 7(33):52643-52660. PMID: 27462916.
    View in: PubMed
  8. Chen SH, Lahav G. Two is better than one; toward a rational design of combinatorial therapy. Curr Opin Struct Biol. 2016 12; 41:145-150. PMID: 27521655.
    View in: PubMed
  9. Paek AL, Liu JC, Loewer A, Forrester WC, Lahav G. Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing. Cell. 2016 Apr 21; 165(3):631-42. PMID: 27062928.
    View in: PubMed
  10. Chen SH, Forrester W, Lahav G. Schedule-dependent interaction between anticancer treatments. Science. 2016 Mar 11; 351(6278):1204-8. PMID: 26965628.
    View in: PubMed
  11. Stewart-Ornstein J, Lahav G. Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit. Cell Rep. 2016 Feb 23; 14(7):1800-1811. PMID: 26876176.
    View in: PubMed
  12. Lande-Diner L, Stewart-Ornstein J, Weitz CJ, Lahav G. Single-cell analysis of circadian dynamics in tissue explants. Mol Biol Cell. 2015 Nov 05; 26(22):3940-5. PMID: 26269583; PMCID: PMC4710227.
  13. Gaglia G, Lahav G. Constant rate of p53 tetramerization in response to DNA damage controls the p53 response. Mol Syst Biol. 2014 Oct 24; 10:753. PMID: 25344068; PMCID: PMC4299375.
  14. Liu JC, Lerou PH, Lahav G. Stem cells: balancing resistance and sensitivity to DNA damage. Trends Cell Biol. 2014 May; 24(5):268-74. PMID: 24721782; PMCID: PMC4342985.
  15. Loewer A, Karanam K, Mock C, Lahav G. The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold. BMC Biol. 2013 Nov 19; 11:114. PMID: 24252182; PMCID: PMC3906995.
  16. Gaglia G, Guan Y, Shah JV, Lahav G. Activation and control of p53 tetramerization in individual living cells. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):15497-501. PMID: 24006363; PMCID: PMC3780836.
  17. Liu JC, Guan X, Ryan JA, Rivera AG, Mock C, Agrawal V, Agarwal V, Letai A, Lerou PH, Lahav G. High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis. Cell Stem Cell. 2013 Oct 03; 13(4):483-91. PMID: 23954752; PMCID: PMC4109647.
  18. Ikeda F, Lahav G. Signal transduction and signaling networks. Mol Biol Cell. 2013 Mar; 24(6):676. PMID: 23486400; PMCID: PMC3596236.
  19. Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW. Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature. 2013 Feb 28; 494(7438):480-3. PMID: 23446419; PMCID: PMC3730528.
  20. Purvis JE, Lahav G. Encoding and decoding cellular information through signaling dynamics. Cell. 2013 Feb 28; 152(5):945-56. PMID: 23452846; PMCID: PMC3707615.
  21. Karanam K, Loewer A, Lahav G. Dynamics of the DNA damage response: insights from live-cell imaging. Brief Funct Genomics. 2013 Mar; 12(2):109-17. PMID: 23292635; PMCID: PMC3609438.
  22. Karanam K, Kafri R, Loewer A, Lahav G. Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase. Mol Cell. 2012 Jul 27; 47(2):320-9. PMID: 22841003; PMCID: PMC3494418.
  23. Purvis JE, Lahav G. Decoding the insulin signal. Mol Cell. 2012 Jun 29; 46(6):715-6. PMID: 22749395; PMCID: PMC4142421.
  24. Purvis JE, Karhohs KW, Mock C, Batchelor E, Loewer A, Lahav G. p53 dynamics control cell fate. Science. 2012 Jun 15; 336(6087):1440-4. PMID: 22700930; PMCID: PMC4162876.
  25. Orth JD, Loewer A, Lahav G, Mitchison TJ. Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell. 2012 Feb; 23(4):567-76. PMID: 22171325; PMCID: PMC3279386.
  26. Loewer A, Lahav G. We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells. Curr Opin Genet Dev. 2011 Dec; 21(6):753-8. PMID: 22005655; PMCID: PMC3270938.
  27. Batchelor E, Lahav G. Suppressing variation in synthetic circuits. Mol Syst Biol. 2011 Aug 02; 7:520. PMID: 21811231; PMCID: PMC3202793.
  28. Batchelor E, Loewer A, Mock C, Lahav G. Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol. 2011 May 10; 7:488. PMID: 21556066; PMCID: PMC3130553.
  29. Toettcher JE, Mock C, Batchelor E, Loewer A, Lahav G. A synthetic-natural hybrid oscillator in human cells. Proc Natl Acad Sci U S A. 2010 Sep 28; 107(39):17047-52. PMID: 20837528; PMCID: PMC2947868.
  30. Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG, Harper JW, Wei W. Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 2010 Aug 09; 18(2):147-59. PMID: 20708156; PMCID: PMC2923652.
  31. Loewer A, Batchelor E, Gaglia G, Lahav G. Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell. 2010 Jul 09; 142(1):89-100. PMID: 20598361; PMCID: PMC3003696.
  32. Geva-Zatorsky N, Dekel E, Batchelor E, Lahav G, Alon U. Fourier analysis and systems identification of the p53 feedback loop. Proc Natl Acad Sci U S A. 2010 Jul 27; 107(30):13550-5. PMID: 20622152; PMCID: PMC2922141.
  33. Lahav G. How to survive and thrive in the mother-mentor marathon. Mol Cell. 2010 May 28; 38(4):477-80. PMID: 20513421.
    View in: PubMed
  34. Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW. Cell growth and size homeostasis in proliferating animal cells. Science. 2009 Jul 10; 325(5937):167-71. PMID: 19589995; PMCID: PMC2905160.
  35. Batchelor E, Loewer A, Lahav G. The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer. 2009 05; 9(5):371-7. PMID: 19360021; PMCID: PMC2892289.
  36. Toettcher JE, Loewer A, Ostheimer GJ, Yaffe MB, Tidor B, Lahav G. Distinct mechanisms act in concert to mediate cell cycle arrest. Proc Natl Acad Sci U S A. 2009 Jan 20; 106(3):785-90. PMID: 19139404; PMCID: PMC2630102.
  37. Batchelor E, Mock CS, Bhan I, Loewer A, Lahav G. Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell. 2008 May 09; 30(3):277-89. PMID: 18471974; PMCID: PMC2579769.
  38. Lahav G. Oscillations by the p53-Mdm2 feedback loop. Adv Exp Med Biol. 2008; 641:28-38. PMID: 18783169.
    View in: PubMed
  39. Eric Bachelor, Caroline Mock, Irun Bhan, Alexander Loewer, and Galit Lahav. Recurrent Initiation: A Mechanism for triggering p53 pulses in response to DNA damage. Submitted. 2007.
  40. Galit Lahav. Chapter: Oscillations by the p53-Mdm2 feedback loop. Cellular Oscillatory Mechanisms, edited by Miguel Maroto and Nick Monk, Landes Bioscience. 2007.
  41. Sigal A, Milo R, Cohen A, Geva-Zatorsky N, Klein Y, Alaluf I, Swerdlin N, Perzov N, Danon T, Liron Y, Raveh T, Carpenter AE, Lahav G, Alon U. Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat Methods. 2006 Jul; 3(7):525-31. PMID: 16791210.
    View in: PubMed
  42. Geva-Zatorsky N, Rosenfeld N, Itzkovitz S, Milo R, Sigal A, Dekel E, Yarnitzky T, Liron Y, Polak P, Lahav G, Alon U. Oscillations and variability in the p53 system. Mol Syst Biol. 2006; 2:2006.0033. PMID: 16773083; PMCID: PMC1681500.
  43. Loewer A, Lahav G. Cellular conference call: external feedback affects cell-fate decisions. Cell. 2006 Mar 24; 124(6):1128-30. PMID: 16564006.
    View in: PubMed
  44. Lahav G. The strength of indecisiveness: oscillatory behavior for better cell fate determination. Sci STKE. 2004 Dec 21; 2004(264):pe55. PMID: 15613687.
    View in: PubMed
  45. Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine AJ, Elowitz MB, Alon U. Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet. 2004 Feb; 36(2):147-50. PMID: 14730303.
    View in: PubMed
  46. Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G. Transcriptional regulation of meiosis in budding yeast. Int Rev Cytol. 2003; 224:111-71. PMID: 12722950.
    View in: PubMed
  47. Shenhar Galit . Transcription regulation of IME1, The master regulators of Meiosis in budding yeast. 2001.
  48. Shenhar G, Kassir Y. A positive regulator of mitosis, Sok2, functions as a negative regulator of meiosis in Saccharomyces cerevisiae. Mol Cell Biol. 2001 Mar; 21(5):1603-12. PMID: 11238897; PMCID: PMC86706.
  49. Sagee S, Sherman A, Shenhar G, Robzyk K, Ben-Doy N, Simchen G, Kassir Y. Multiple and distinct activation and repression sequences mediate the regulated transcription of IME1, a transcriptional activator of meiosis-specific genes in Saccharomyces cerevisiae. Mol Cell Biol. 1998 Apr; 18(4):1985-95. PMID: 9528770; PMCID: PMC121428.
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