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Galit Lahav, Ph.D.

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Mentoring
Pharmacological Perturbations of the p53 Pathway: p53-Chk2 Feedback
Summer, 06/01/06 - 08/22/06

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01GM116864 (LAHAV, GALIT) Feb 1, 2017 - Dec 31, 2020
    NIH/NIGMS
    Dynamics of Cellular Senescence in Single Cells
    Role: Principal Investigator
  2. R01GM105375 (GUNAWARDENA, JEREMY) Dec 15, 2014 - Nov 30, 2018
    NIH/NIGMS
    Information Processing by Post-translational Modification
    Role: Co-Principal Investigator
  3. R01GM083303 (LAHAV, GALIT) Mar 1, 2008 - May 31, 2021
    NIH/NIGMS
    Dynamics of Signaling Pathways: Mechanism and Function
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Tsabar M, Mock CS, Venkatachalam V, Reyes J, Karhohs KW, Oliver TG, Regev A, Jambhekar A, Lahav G. A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest. Cell Rep. 2020 Aug 04; 32(5):107995. PMID: 32755587.
    Citations:    Fields:    
  2. Hafner A, Reyes J, Stewart-Ornstein J, Tsabar M, Jambhekar A, Lahav G. Quantifying the Central Dogma in the p53 Pathway in Live Single Cells. Cell Syst. 2020 Jun 24; 10(6):495-505.e4. PMID: 32533938.
    Citations: 2     Fields:    
  3. Hafner A, Kublo L, Tsabar M, Lahav G, Stewart-Ornstein J. Identification of universal and cell-type specific p53 DNA binding. BMC Mol Cell Biol. 2020 Feb 18; 21(1):5. PMID: 32070277.
    Citations: 1     Fields:    
  4. Granada AE, Jiménez A, Stewart-Ornstein J, Blüthgen N, Reber S, Jambhekar A, Lahav G. The effects of proliferation status and cell cycle phase on the responses of single cells to chemotherapy. Mol Biol Cell. 2020 04 01; 31(8):845-857. PMID: 32049575.
    Citations: 1     Fields:    
  5. Heltberg ML, Chen SH, Jiménez A, Jambhekar A, Jensen MH, Lahav G. Inferring Leading Interactions in the p53/Mdm2/Mdmx Circuit through Live-Cell Imaging and Modeling. Cell Syst. 2019 12 18; 9(6):548-558.e5. PMID: 31812692.
    Citations: 2     Fields:    Translation:HumansCells
  6. Ardon-Dryer K, Mock C, Reyes J, Lahav G. The effect of dust storm particles on single human lung cancer cells. Environ Res. 2020 02; 181:108891. PMID: 31740036.
    Citations:    Fields:    Translation:Humans
  7. Gilad T, Reyes J, Chen JY, Lahav G, Riklin Raviv T. Fully unsupervised symmetry-based mitosis detection in time-lapse cell microscopy. Bioinformatics. 2019 08 01; 35(15):2644-2653. PMID: 30590471.
    Citations:    Fields:    
  8. Hafner A, Bulyk ML, Jambhekar A, Lahav G. The multiple mechanisms that regulate p53 activity and cell fate. Nat Rev Mol Cell Biol. 2019 04; 20(4):199-210. PMID: 30824861.
    Citations: 53     Fields:    Translation:HumansAnimals
  9. Reyes J, Chen JY, Stewart-Ornstein J, Karhohs KW, Mock CS, Lahav G. Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest. Mol Cell. 2019 03 21; 73(6):1306. PMID: 30901565.
    Citations:    Fields:    
  10. Chakrabarti S, Paek AL, Reyes J, Lasick KA, Lahav G, Michor F. Hidden heterogeneity and circadian-controlled cell fate inferred from single cell lineages. Nat Commun. 2018 12 18; 9(1):5372. PMID: 30560953.
    Citations: 4     Fields:    Translation:HumansCells
  11. Reyes J, Chen JY, Stewart-Ornstein J, Karhohs KW, Mock CS, Lahav G. Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest. Mol Cell. 2018 08 16; 71(4):581-591.e5. PMID: 30057196.
    Citations: 12     Fields:    Translation:HumansCells
  12. Arbelle A, Reyes J, Chen JY, Lahav G, Riklin Raviv T. A probabilistic approach to joint cell tracking and segmentation in high-throughput microscopy videos. Med Image Anal. 2018 07; 47:140-152. PMID: 29747154.
    Citations: 3     Fields:    Translation:Humans
  13. Reyes J, Lahav G. Leveraging and coping with uncertainty in the response of individual cells to therapy. Curr Opin Biotechnol. 2018 06; 51:109-115. PMID: 29288931.
    Citations: 1     Fields:    Translation:HumansCells
  14. Stewart-Ornstein J, Cheng HWJ, Lahav G. Conservation and Divergence of p53 Oscillation Dynamics across Species. Cell Syst. 2017 10 25; 5(4):410-417.e4. PMID: 29055670.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  15. Hafner A, Stewart-Ornstein J, Purvis JE, Forrester WC, Bulyk ML, Lahav G. p53 pulses lead to distinct patterns of gene expression albeit similar DNA-binding dynamics. Nat Struct Mol Biol. 2017 Oct; 24(10):840-847. PMID: 28825732.
    Citations: 16     Fields:    Translation:HumansCells
  16. Oppenheim A, Lahav G. The puzzling interplay between p53 and Sp1. Aging (Albany NY). 2017 May 09; 9(5):1355-1356. PMID: 28490691.
    Citations: 3     Fields:    Translation:HumansCells
  17. Tsabar M, Lahav G. The Single-Cell Yin and Yang of Live Imaging and Transcriptomics. Cell Syst. 2017 04 26; 4(4):375-377. PMID: 28448797.
    Citations:    Fields:    Translation:Cells
  18. Stewart-Ornstein J, Lahav G. p53 dynamics in response to DNA damage vary across cell lines and are shaped by efficiency of DNA repair and activity of the kinase ATM. Sci Signal. 2017 Apr 25; 10(476). PMID: 28442631.
    Citations: 14     Fields:    Translation:HumansCells
  19. Stewart-Ornstein J, Lahav G. Integrating genomic information and signaling dynamics for efficient cancer therapy. Curr Opin Syst Biol. 2017 Feb; 1:38-43. PMID: 28944311.
    Citations:    
  20. Drayman N, Ben-Nun-Shaul O, Butin-Israeli V, Srivastava R, Rubinstein AM, Mock CS, Elyada E, Ben-Neriah Y, Lahav G, Oppenheim A. p53 elevation in human cells halt SV40 infection by inhibiting T-ag expression. Oncotarget. 2016 Aug 16; 7(33):52643-52660. PMID: 27462916.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  21. Chen SH, Lahav G. Two is better than one; toward a rational design of combinatorial therapy. Curr Opin Struct Biol. 2016 12; 41:145-150. PMID: 27521655.
    Citations: 8     Fields:    Translation:HumansCells
  22. Paek AL, Liu JC, Loewer A, Forrester WC, Lahav G. Cell-to-Cell Variation in p53 Dynamics Leads to Fractional Killing. Cell. 2016 Apr 21; 165(3):631-42. PMID: 27062928.
    Citations: 61     Fields:    Translation:HumansCells
  23. Chen SH, Forrester W, Lahav G. Schedule-dependent interaction between anticancer treatments. Science. 2016 Mar 11; 351(6278):1204-8. PMID: 26965628.
    Citations: 24     Fields:    Translation:HumansCells
  24. Stewart-Ornstein J, Lahav G. Dynamics of CDKN1A in Single Cells Defined by an Endogenous Fluorescent Tagging Toolkit. Cell Rep. 2016 Feb 23; 14(7):1800-1811. PMID: 26876176.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  25. Lande-Diner L, Stewart-Ornstein J, Weitz CJ, Lahav G. Single-cell analysis of circadian dynamics in tissue explants. Mol Biol Cell. 2015 Nov 05; 26(22):3940-5. PMID: 26269583.
    Citations: 6     Fields:    Translation:AnimalsCells
  26. Gaglia G, Lahav G. Constant rate of p53 tetramerization in response to DNA damage controls the p53 response. Mol Syst Biol. 2014 Oct 24; 10:753. PMID: 25344068.
    Citations: 11     Fields:    Translation:HumansCells
  27. Liu JC, Lerou PH, Lahav G. Stem cells: balancing resistance and sensitivity to DNA damage. Trends Cell Biol. 2014 May; 24(5):268-74. PMID: 24721782.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  28. Loewer A, Karanam K, Mock C, Lahav G. The p53 response in single cells is linearly correlated to the number of DNA breaks without a distinct threshold. BMC Biol. 2013 Nov 19; 11:114. PMID: 24252182.
    Citations: 24     Fields:    Translation:HumansCells
  29. Gaglia G, Guan Y, Shah JV, Lahav G. Activation and control of p53 tetramerization in individual living cells. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):15497-501. PMID: 24006363.
    Citations: 40     Fields:    Translation:HumansCells
  30. Liu JC, Guan X, Ryan JA, Rivera AG, Mock C, Agrawal V, Agarwal V, Letai A, Lerou PH, Lahav G. High mitochondrial priming sensitizes hESCs to DNA-damage-induced apoptosis. Cell Stem Cell. 2013 Oct 03; 13(4):483-91. PMID: 23954752.
    Citations: 58     Fields:    Translation:HumansCells
  31. Ikeda F, Lahav G. Signal transduction and signaling networks. Mol Biol Cell. 2013 Mar; 24(6):676. PMID: 23486400.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  32. Kafri R, Levy J, Ginzberg MB, Oh S, Lahav G, Kirschner MW. Dynamics extracted from fixed cells reveal feedback linking cell growth to cell cycle. Nature. 2013 Feb 28; 494(7438):480-3. PMID: 23446419.
    Citations: 69     Fields:    Translation:HumansCells
  33. Purvis JE, Lahav G. Encoding and decoding cellular information through signaling dynamics. Cell. 2013 Feb 28; 152(5):945-56. PMID: 23452846.
    Citations: 204     Fields:    Translation:HumansAnimalsCells
  34. Karanam K, Loewer A, Lahav G. Dynamics of the DNA damage response: insights from live-cell imaging. Brief Funct Genomics. 2013 Mar; 12(2):109-17. PMID: 23292635.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  35. Karanam K, Kafri R, Loewer A, Lahav G. Quantitative live cell imaging reveals a gradual shift between DNA repair mechanisms and a maximal use of HR in mid S phase. Mol Cell. 2012 Jul 27; 47(2):320-9. PMID: 22841003.
    Citations: 123     Fields:    Translation:HumansCells
  36. Purvis JE, Lahav G. Decoding the insulin signal. Mol Cell. 2012 Jun 29; 46(6):715-6. PMID: 22749395.
    Citations: 5     Fields:    
  37. Purvis JE, Karhohs KW, Mock C, Batchelor E, Loewer A, Lahav G. p53 dynamics control cell fate. Science. 2012 Jun 15; 336(6087):1440-4. PMID: 22700930.
    Citations: 221     Fields:    Translation:HumansCells
  38. Orth JD, Loewer A, Lahav G, Mitchison TJ. Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction. Mol Biol Cell. 2012 Feb; 23(4):567-76. PMID: 22171325.
    Citations: 84     Fields:    Translation:HumansCells
  39. Loewer A, Lahav G. We are all individuals: causes and consequences of non-genetic heterogeneity in mammalian cells. Curr Opin Genet Dev. 2011 Dec; 21(6):753-8. PMID: 22005655.
    Citations: 26     Fields:    Translation:HumansCells
  40. Batchelor E, Lahav G. Suppressing variation in synthetic circuits. Mol Syst Biol. 2011 Aug 02; 7:520. PMID: 21811231.
    Citations: 1     Fields:    Translation:Humans
  41. Batchelor E, Loewer A, Mock C, Lahav G. Stimulus-dependent dynamics of p53 in single cells. Mol Syst Biol. 2011 May 10; 7:488. PMID: 21556066.
    Citations: 106     Fields:    Translation:HumansCells
  42. Toettcher JE, Mock C, Batchelor E, Loewer A, Lahav G. A synthetic-natural hybrid oscillator in human cells. Proc Natl Acad Sci U S A. 2010 Sep 28; 107(39):17047-52. PMID: 20837528.
    Citations: 14     Fields:    Translation:HumansCells
  43. Inuzuka H, Tseng A, Gao D, Zhai B, Zhang Q, Shaik S, Wan L, Ang XL, Mock C, Yin H, Stommel JM, Gygi S, Lahav G, Asara J, Xiao ZX, Kaelin WG, Harper JW, Wei W. Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase. Cancer Cell. 2010 Aug 09; 18(2):147-59. PMID: 20708156.
    Citations: 100     Fields:    Translation:HumansAnimalsCells
  44. Loewer A, Batchelor E, Gaglia G, Lahav G. Basal dynamics of p53 reveal transcriptionally attenuated pulses in cycling cells. Cell. 2010 Jul 09; 142(1):89-100. PMID: 20598361.
    Citations: 113     Fields:    Translation:HumansCells
  45. Geva-Zatorsky N, Dekel E, Batchelor E, Lahav G, Alon U. Fourier analysis and systems identification of the p53 feedback loop. Proc Natl Acad Sci U S A. 2010 Jul 27; 107(30):13550-5. PMID: 20622152.
    Citations: 29     Fields:    Translation:HumansCells
  46. Lahav G. How to survive and thrive in the mother-mentor marathon. Mol Cell. 2010 May 28; 38(4):477-80. PMID: 20513421.
    Citations: 1     Fields:    Translation:Humans
  47. Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW. Cell growth and size homeostasis in proliferating animal cells. Science. 2009 Jul 10; 325(5937):167-71. PMID: 19589995.
    Citations: 126     Fields:    Translation:AnimalsCells
  48. Batchelor E, Loewer A, Lahav G. The ups and downs of p53: understanding protein dynamics in single cells. Nat Rev Cancer. 2009 05; 9(5):371-7. PMID: 19360021.
    Citations: 75     Fields:    Translation:HumansAnimalsCells
  49. Toettcher JE, Loewer A, Ostheimer GJ, Yaffe MB, Tidor B, Lahav G. Distinct mechanisms act in concert to mediate cell cycle arrest. Proc Natl Acad Sci U S A. 2009 Jan 20; 106(3):785-90. PMID: 19139404.
    Citations: 37     Fields:    Translation:HumansCells
  50. Batchelor E, Mock CS, Bhan I, Loewer A, Lahav G. Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol Cell. 2008 May 09; 30(3):277-89. PMID: 18471974.
    Citations: 140     Fields:    Translation:HumansAnimalsCells
  51. Lahav G. Oscillations by the p53-Mdm2 feedback loop. Adv Exp Med Biol. 2008; 641:28-38. PMID: 18783169.
    Citations: 26     Fields:    Translation:HumansCells
  52. Eric Bachelor, Caroline Mock, Irun Bhan, Alexander Loewer, and Galit Lahav. Recurrent Initiation: A Mechanism for triggering p53 pulses in response to DNA damage. Submitted. 2007.
  53. Galit Lahav. Chapter: Oscillations by the p53-Mdm2 feedback loop. Cellular Oscillatory Mechanisms, edited by Miguel Maroto and Nick Monk, Landes Bioscience. 2007.
  54. Sigal A, Milo R, Cohen A, Geva-Zatorsky N, Klein Y, Alaluf I, Swerdlin N, Perzov N, Danon T, Liron Y, Raveh T, Carpenter AE, Lahav G, Alon U. Dynamic proteomics in individual human cells uncovers widespread cell-cycle dependence of nuclear proteins. Nat Methods. 2006 Jul; 3(7):525-31. PMID: 16791210.
    Citations: 55     Fields:    Translation:HumansCells
  55. Geva-Zatorsky N, Rosenfeld N, Itzkovitz S, Milo R, Sigal A, Dekel E, Yarnitzky T, Liron Y, Polak P, Lahav G, Alon U. Oscillations and variability in the p53 system. Mol Syst Biol. 2006; 2:2006.0033. PMID: 16773083.
    Citations: 192     Fields:    Translation:HumansCells
  56. Loewer A, Lahav G. Cellular conference call: external feedback affects cell-fate decisions. Cell. 2006 Mar 24; 124(6):1128-30. PMID: 16564006.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  57. Lahav G. The strength of indecisiveness: oscillatory behavior for better cell fate determination. Sci STKE. 2004 Dec 21; 2004(264):pe55. PMID: 15613687.
    Citations: 16     Fields:    Translation:HumansAnimals
  58. Lahav G, Rosenfeld N, Sigal A, Geva-Zatorsky N, Levine AJ, Elowitz MB, Alon U. Dynamics of the p53-Mdm2 feedback loop in individual cells. Nat Genet. 2004 Feb; 36(2):147-50. PMID: 14730303.
    Citations: 316     Fields:    Translation:HumansCells
  59. Kassir Y, Adir N, Boger-Nadjar E, Raviv NG, Rubin-Bejerano I, Sagee S, Shenhar G. Transcriptional regulation of meiosis in budding yeast. Int Rev Cytol. 2003; 224:111-71. PMID: 12722950.
    Citations: 81     Fields:    Translation:AnimalsCells
  60. Shenhar Galit . Transcription regulation of IME1, The master regulators of Meiosis in budding yeast. 2001.
  61. Shenhar G, Kassir Y. A positive regulator of mitosis, Sok2, functions as a negative regulator of meiosis in Saccharomyces cerevisiae. Mol Cell Biol. 2001 Mar; 21(5):1603-12. PMID: 11238897.
    Citations: 32     Fields:    Translation:AnimalsCells
  62. Sagee S, Sherman A, Shenhar G, Robzyk K, Ben-Doy N, Simchen G, Kassir Y. Multiple and distinct activation and repression sequences mediate the regulated transcription of IME1, a transcriptional activator of meiosis-specific genes in Saccharomyces cerevisiae. Mol Cell Biol. 1998 Apr; 18(4):1985-95. PMID: 9528770.
    Citations: 37     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.