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Vadim Gladyshev, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK117149 (GLADYSHEV, VADIM N.) Apr 1, 2018 - Mar 31, 2023
    NIH/NIDDK
    Systems level understanding of selenoprotein biosynthesis
    Role: Principal Investigator
  2. P01AG047200 (GORBUNOVA, VERA) May 1, 2014 - Apr 30, 2019
    NIH/NIA
    Comparative genomes of longevity
    Role: Co-Principal Investigator
  3. DP1AG047745 (GLADYSHEV, VADIM N.) Sep 30, 2013 - May 31, 2019
    NIH/NIA
    Mechanisms of lifespan control
    Role: Principal Investigator
  4. R01AG038004 (GLADYSHEV, VADIM N.) Aug 1, 2010 - Jul 31, 2014
    NIH/NIA
    Understanding the Causes of Aging
    Role: Principal Investigator
  5. R13CA121806 (GLADYSHEV, VADIM N.) Jun 7, 2006 - May 31, 2007
    NIH/NCI
    2006 Thiol-based Redox Regulation and Signaling Gordon Research Conference
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Anisimova AS, Alexandrov AI, Makarova NE, Gladyshev VN, Dmitriev SE. Protein synthesis and quality control in aging. Aging (Albany NY). 2018 Dec 18; 10(12):4269-4288. PMID: 30562164.
    View in: PubMed
  2. Meer MV, Podolskiy DI, Tyshkovskiy A, Gladyshev VN. A whole lifespan mouse multi-tissue DNA methylation clock. Elife. 2018 11 14; 7. PMID: 30427307.
    View in: PubMed
  3. Bakula D, Aliper AM, Mamoshina P, Petr MA, Teklu A, Baur JA, Campisi J, Ewald CY, Georgievskaya A, Gladyshev VN, Kovalchuk O, Lamming DW, Luijsterburg MS, Martín-Montalvo A, Maudsley S, Mkrtchyan GV, Moskalev A, Olshansky SJ, Ozerov IV, Pickett A, Ristow M, Zhavoronkov A, Scheibye-Knudsen M. Aging and drug discovery. Aging (Albany NY). 2018 Nov 13; 10(11):3079-3088. PMID: 30425188.
    View in: PubMed
  4. Ogrodnik M, Salmonowicz H, Gladyshev VN. Integrating cellular senescence with the concept of damage accumulation in aging: Relevance for clearance of senescent cells. Aging Cell. 2018 Oct 22; e12841. PMID: 30346102.
    View in: PubMed
  5. Seluanov A, Gladyshev VN, Vijg J, Gorbunova V. Mechanisms of cancer resistance in long-lived mammals. Nat Rev Cancer. 2018 Jul; 18(7):433-441. PMID: 29622806.
    View in: PubMed
  6. Lee SG, Mikhalchenko AE, Yim SH, Gladyshev VN. A naked mole rat iPSC line expressing drug-inducible mouse pluripotency factors developed from embryonic fibroblasts. Stem Cell Res. 2018 Aug; 31:197-200. PMID: 30107334.
    View in: PubMed
  7. Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018 Jun 13; 10(445). PMID: 29899023.
    View in: PubMed
  8. Peters KM, Carlson BA, Gladyshev VN, Tsuji PA. Selenoproteins in colon cancer. Free Radic Biol Med. 2018 Nov 01; 127:14-25. PMID: 29793041.
    View in: PubMed
  9. Yim SH, Everley RA, Schildberg FA, Lee SG, Orsi A, Barbati ZR, Karatepe K, Fomenko DE, Tsuji PA, Luo HR, Gygi SP, Sitia R, Sharpe AH, Hatfield DL, Gladyshev VN. Role of Selenof as a Gatekeeper of Secreted Disulfide-Rich Glycoproteins. Cell Rep. 2018 May 01; 23(5):1387-1398. PMID: 29719252.
    View in: PubMed
  10. Na J, Jung J, Bang J, Lu Q, Carlson BA, Guo X, Gladyshev VN, Kim J, Hatfield DL, Lee BJ. Selenophosphate synthetase 1 and its role in redox homeostasis, defense and proliferation. Free Radic Biol Med. 2018 Nov 01; 127:190-197. PMID: 29715549.
    View in: PubMed
  11. Ma S, Avanesov AS, Porter E, Lee BC, Mariotti M, Zemskaya N, Guigo R, Moskalev AA, Gladyshev VN. Comparative transcriptomics across 14 Drosophila species reveals signatures of longevity. Aging Cell. 2018 Apr 19; e12740. PMID: 29671950.
    View in: PubMed
  12. Zhou X, Guang X, Sun D, Xu S, Li M, Seim I, Jie W, Yang L, Zhu Q, Xu J, Gao Q, Kaya A, Dou Q, Chen B, Ren W, Li S, Zhou K, Gladyshev VN, Nielsen R, Fang X, Yang G. Population genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater. Nat Commun. 2018 04 10; 9(1):1276. PMID: 29636446.
    View in: PubMed
  13. Sziráki A, Tyshkovskiy A, Gladyshev VN. Global remodeling of the mouse DNA methylome during aging and in response to calorie restriction. Aging Cell. 2018 Jun; 17(3):e12738. PMID: 29575528.
    View in: PubMed
  14. Zhou X, Sun D, Guang X, Ma S, Fang X, Mariotti M, Nielsen R, Gladyshev VN, Yang G. Molecular Footprints of Aquatic Adaptation Including Bone Mass Changes in Cetaceans. Genome Biol Evol. 2018 03 01; 10(3):967-975. PMID: 29608729.
    View in: PubMed
  15. Zhao Y, Tyshkovskiy A, Muñoz-Espín D, Tian X, Serrano M, de Magalhaes JP, Nevo E, Gladyshev VN, Seluanov A, Gorbunova V. Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescence. Proc Natl Acad Sci U S A. 2018 02 20; 115(8):1801-1806. PMID: 29432174.
    View in: PubMed
  16. Lee BC, Lee HM, Kim S, Avanesov AS, Lee A, Chun BH, Vorbruggen G, Gladyshev VN. Expression of the methionine sulfoxide reductase lost during evolution extends Drosophila lifespan in a methionine-dependent manner. Sci Rep. 2018 01 17; 8(1):1010. PMID: 29343716.
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  17. Yordanova MM, Loughran G, Zhdanov AV, Mariotti M, Kiniry SJ, O'Connor PBF, Andreev DE, Tzani I, Saffert P, Michel AM, Gladyshev VN, Papkovsky DB, Atkins JF, Baranov PV. AMD1 mRNA employs ribosome stalling as a mechanism for molecular memory formation. Nature. 2018 01 18; 553(7688):356-360. PMID: 29310120.
    View in: PubMed
  18. Tarrago L, Oheix E, Péterfi Z, Gladyshev VN. Monitoring of Methionine Sulfoxide Content and Methionine Sulfoxide Reductase Activity. Methods Mol Biol. 2018; 1661:285-299. PMID: 28917052.
    View in: PubMed
  19. Carlson BA, Lee BJ, Tsuji PA, Copeland PR, Schweizer U, Gladyshev VN, Hatfield DL. Selenocysteine tRNA[Ser]Sec, the Central Component of Selenoprotein Biosynthesis: Isolation, Identification, Modification, and Sequencing. Methods Mol Biol. 2018; 1661:43-60. PMID: 28917036.
    View in: PubMed
  20. Tang Q, Gu Y, Zhou X, Jin L, Guan J, Liu R, Li J, Long K, Tian S, Che T, Hu S, Liang Y, Yang X, Tao X, Zhong Z, Wang G, Chen X, Li D, Ma J, Wang X, Mai M, Jiang A, Luo X, Lv X, Gladyshev VN, Li X, Li M. Comparative transcriptomics of 5 high-altitude vertebrates and their low-altitude relatives. Gigascience. 2017 12 01; 6(12):1-9. PMID: 29149296.
    View in: PubMed
  21. Lee SG, Mikhalchenko AE, Yim SH, Lobanov AV, Park JK, Choi KH, Bronson RT, Lee CK, Park TJ, Gladyshev VN. Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera. Stem Cell Reports. 2017 11 14; 9(5):1706-1720. PMID: 29107591.
    View in: PubMed
  22. Golubev A, Hanson AD, Gladyshev VN. A Tale of Two Concepts: Harmonizing the Free Radical and Antagonistic Pleiotropy Theories of Aging. Antioxid Redox Signal. 2018 Oct 01; 29(10):1003-1017. PMID: 28874059.
    View in: PubMed
  23. Kim KY, Kwak GH, Singh MP, Gladyshev VN, Kim HY. Selenoprotein MsrB1 deficiency exacerbates acetaminophen-induced hepatotoxicity via increased oxidative damage. Arch Biochem Biophys. 2017 11 15; 634:69-75. PMID: 28986131.
    View in: PubMed
  24. Ma S, Gladyshev VN. Molecular signatures of longevity: Insights from cross-species comparative studies. Semin Cell Dev Biol. 2017 10; 70:190-203. PMID: 28800931.
    View in: PubMed
  25. Kaya A, Mariotti M, Gladyshev VN. Cytochrome c peroxidase facilitates the beneficial use of H2O2 in prokaryotes. Proc Natl Acad Sci U S A. 2017 08 15; 114(33):8678-8680. PMID: 28765365.
    View in: PubMed
  26. Ke Z, Mallik P, Johnson AB, Luna F, Nevo E, Zhang ZD, Gladyshev VN, Seluanov A, Gorbunova V. Translation fidelity coevolves with longevity. Aging Cell. 2017 10; 16(5):988-993. PMID: 28707419.
    View in: PubMed
  27. Lee BC, Lee SG, Choo MK, Kim JH, Lee HM, Kim S, Fomenko DE, Kim HY, Park JM, Gladyshev VN. Selenoprotein MsrB1 promotes anti-inflammatory cytokine gene expression in macrophages and controls immune response in vivo. Sci Rep. 2017 07 11; 7(1):5119. PMID: 28698597.
    View in: PubMed
  28. Renko K, Martitz J, Hybsier S, Heynisch B, Voss L, Everley RA, Gygi SP, Stoedter M, Wisniewska M, Köhrle J, Gladyshev VN, Schomburg L. Aminoglycoside-driven biosynthesis of selenium-deficient Selenoprotein P. Sci Rep. 2017 06 29; 7(1):4391. PMID: 28663583.
    View in: PubMed
  29. Salinas G, Gao W, Wang Y, Bonilla M, Yu L, Novikov A, Virginio VG, Ferreira HB, Vieites M, Gladyshev VN, Gambino D, Dai S. The Enzymatic and Structural Basis for Inhibition of Echinococcus granulosus Thioredoxin Glutathione Reductase by Gold(I). Antioxid Redox Signal. 2017 Dec 20; 27(18):1491-1504. PMID: 28463568.
    View in: PubMed
  30. Petkovich DA, Podolskiy DI, Lobanov AV, Lee SG, Miller RA, Gladyshev VN. Using DNA Methylation Profiling to Evaluate Biological Age and Longevity Interventions. Cell Metab. 2017 Apr 04; 25(4):954-960.e6. PMID: 28380383.
    View in: PubMed
  31. Golubev A, Hanson AD, Gladyshev VN. Non-enzymatic molecular damage as a prototypic driver of aging. J Biol Chem. 2017 04 14; 292(15):6029-6038. PMID: 28264930.
    View in: PubMed
  32. Lee SG, Kaya A, Avanesov AS, Podolskiy DI, Song EJ, Go DM, Jin GD, Hwang JY, Kim EB, Kim DY, Gladyshev VN. Age-associated molecular changes are deleterious and may modulate life span through diet. Sci Adv. 2017 Feb; 3(2):e1601833. PMID: 28232953.
    View in: PubMed
  33. Manta B, Gladyshev VN. Regulated methionine oxidation by monooxygenases. Free Radic Biol Med. 2017 08; 109:141-155. PMID: 28229915.
    View in: PubMed
  34. Moskalev A, Anisimov V, Aliper A, Artemov A, Asadullah K, Belsky D, Baranova A, de Grey A, Dixit VD, Debonneuil E, Dobrovolskaya E, Fedichev P, Fedintsev A, Fraifeld V, Franceschi C, Freer R, Fülöp T, Feige J, Gems D, Gladyshev V, Gorbunova V, Irincheeva I, Jager S, Jazwinski SM, Kaeberlein M, Kennedy B, Khaltourina D, Kovalchuk I, Kovalchuk O, Kozin S, Kulminski A, Lashmanova E, Lezhnina K, Liu GH, Longo V, Mamoshina P, Maslov A, Pedro de Magalhaes J, Mitchell J, Mitnitski A, Nikolsky Y, Ozerov I, Pasyukova E, Peregudova D, Popov V, Proshkina E, Putin E, Rogaev E, Rogina B, Schastnaya J, Seluanov A, Shaposhnikov M, Simm A, Skulachev V, Skulachev M, Solovev I, Spindler S, Stefanova N, Suh Y, Swick A, Tower J, Gudkov AV, Vijg J, Voronkov A, West M, Wagner W, Yashin A, Zemskaya N, Zhumadilov Z, Zhavoronkov A. A review of the biomedical innovations for healthy longevity. Aging (Albany NY). 2017 Jan 29; 9(1):7-25. PMID: 28132958.
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  35. Payne NC, Geissler A, Button A, Sasuclark AR, Schroll AL, Ruggles EL, Gladyshev VN, Hondal RJ. Comparison of the redox chemistry of sulfur- and selenium-containing analogs of uracil. Free Radic Biol Med. 2017 03; 104:249-261. PMID: 28108278.
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  36. Heo JY, Cha HN, Kim KY, Lee E, Kim SJ, Kim YW, Kim JY, Lee IK, Gladyshev VN, Kim HY, Park SY. Methionine sulfoxide reductase B1 deficiency does not increase high-fat diet-induced insulin resistance in mice. Free Radic Res. 2017 Jan; 51(1):24-37. PMID: 27838938.
    View in: PubMed
  37. Ma S, Upneja A, Galecki A, Tsai YM, Burant CF, Raskind S, Zhang Q, Zhang ZD, Seluanov A, Gorbunova V, Clish CB, Miller RA, Gladyshev VN. Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity. Elife. 2016 11 22; 5. PMID: 27874830.
    View in: PubMed
  38. Lobanov AV, Heaphy SM, Turanov AA, Gerashchenko MV, Pucciarelli S, Devaraj RR, Xie F, Petyuk VA, Smith RD, Klobutcher LA, Atkins JF, Miceli C, Hatfield DL, Baranov PV, Gladyshev VN. Position-dependent termination and widespread obligatory frameshifting in Euplotes translation. Nat Struct Mol Biol. 2017 01; 24(1):61-68. PMID: 27870834.
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  39. Gladyshev TV, Gladyshev VN. A Disease or Not a Disease? Aging As a Pathology. Trends Mol Med. 2016 12; 22(12):995-996. PMID: 27793599.
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  40. Li M, Chen L, Tian S, Lin Y, Tang Q, Zhou X, Li D, Yeung CKL, Che T, Jin L, Fu Y, Ma J, Wang X, Jiang A, Lan J, Pan Q, Liu Y, Luo Z, Guo Z, Liu H, Zhu L, Shuai S, Tang G, Zhao J, Jiang Y, Bai L, Zhang S, Mai M, Li C, Wang D, Gu Y, Wang G, Lu H, Li Y, Zhu H, Li Z, Li M, Gladyshev VN, Jiang Z, Zhao S, Wang J, Li R, Li X. Comprehensive variation discovery and recovery of missing sequence in the pig genome using multiple de novo assemblies. Genome Res. 2017 05; 27(5):865-874. PMID: 27646534.
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  41. Gladyshev VN, Arnér ES, Berry MJ, Brigelius-Flohé R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Flohé L, Green FR, Guigó R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Köhrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovic M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y. Selenoprotein Gene Nomenclature. J Biol Chem. 2016 Nov 11; 291(46):24036-24040. PMID: 27645994.
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  42. Gerashchenko MV, Gladyshev VN. Ribonuclease selection for ribosome profiling. Nucleic Acids Res. 2017 01 25; 45(2):e6. PMID: 27638886.
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  43. Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Chang CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W. Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proc Natl Acad Sci U S A. 2016 09 20; 113(38):E5562-71. PMID: 27588899.
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  44. Zhou X, Meng X, Liu Z, Chang J, Wang B, Li M, Wengel PO, Tian S, Wen C, Wang Z, Garber PA, Pan H, Ye X, Xiang Z, Bruford MW, Edwards SV, Cao Y, Yu S, Gao L, Cao Z, Liu G, Ren B, Shi F, Peterfi Z, Li D, Li B, Jiang Z, Li J, Gladyshev VN, Li R, Li M. Population Genomics Reveals Low Genetic Diversity and Adaptation to Hypoxia in Snub-Nosed Monkeys. Mol Biol Evol. 2016 10; 33(10):2670-81. PMID: 27555581.
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  45. Podolskiy DI, Gladyshev VN. Intrinsic Versus Extrinsic Cancer Risk Factors and Aging. Trends Mol Med. 2016 Oct; 22(10):833-834. PMID: 27544777.
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  46. Podolskiy DI, Lobanov AV, Kryukov GV, Gladyshev VN. Analysis of cancer genomes reveals basic features of human aging and its role in cancer development. Nat Commun. 2016 08 12; 7:12157. PMID: 27515585.
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  47. Heaphy SM, Mariotti M, Gladyshev VN, Atkins JF, Baranov PV. Novel Ciliate Genetic Code Variants Including the Reassignment of All Three Stop Codons to Sense Codons in Condylostoma magnum. Mol Biol Evol. 2016 11; 33(11):2885-2889. PMID: 27501944.
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  48. Mariotti M, Lobanov AV, Manta B, Santesmasses D, Bofill A, Guigó R, Gabaldón T, Gladyshev VN. Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems. Mol Biol Evol. 2016 09; 33(9):2441-53. PMID: 27413050; PMCID: PMC4989117.
  49. Seim I, Ma S, Gladyshev VN. Gene expression signatures of human cell and tissue longevity. NPJ Aging Mech Dis. 2016; 2:16014. PMID: 28721269.
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  50. Péterfi Z, Tarrago L, Gladyshev VN. Practical guide for dynamic monitoring of protein oxidation using genetically encoded ratiometric fluorescent biosensors of methionine sulfoxide. Methods. 2016 10 15; 109:149-157. PMID: 27345570.
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  51. Carlson BA, Tobe R, Yefremova E, Tsuji PA, Hoffmann VJ, Schweizer U, Gladyshev VN, Hatfield DL, Conrad M. Glutathione peroxidase 4 and vitamin E cooperatively prevent hepatocellular degeneration. Redox Biol. 2016 10; 9:22-31. PMID: 27262435.
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  52. Tobe R, Carlson BA, Huh JH, Castro NP, Xu XM, Tsuji PA, Lee SG, Bang J, Na JW, Kong YY, Beaglehole D, Southon E, Seifried H, Tessarollo L, Salomon DS, Schweizer U, Gladyshev VN, Hatfield DL, Lee BJ. Selenophosphate synthetase 1 is an essential protein with roles in regulation of redox homoeostasis in mammals. Biochem J. 2016 07 15; 473(14):2141-54. PMID: 27208177.
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  53. Patrick A, Seluanov M, Hwang C, Tam J, Khan T, Morgenstern A, Wiener L, Vazquez JM, Zafar H, Wen R, Muratkalyeva M, Doerig K, Zagorulya M, Cole L, Catalano S, Lobo Ladd AA, Coppi AA, Coskun Y, Tian X, Ablaeva J, Nevo E, Gladyshev VN, Zhang ZD, Vijg J, Seluanov A, Gorbunova V. Sensitivity of primary fibroblasts in culture to atmospheric oxygen does not correlate with species lifespan. Aging (Albany NY). 2016 05; 8(5):841-7. PMID: 27163160.
    View in: PubMed
  54. Gladyshev VN. Aging: progressive decline in fitness due to the rising deleteriome adjusted by genetic, environmental, and stochastic processes. Aging Cell. 2016 08; 15(4):594-602. PMID: 27060562.
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  55. Lee BC, Kaya A, Gladyshev VN. Methionine restriction and life-span control. Ann N Y Acad Sci. 2016 Jan; 1363:116-24. PMID: 26663138; PMCID: PMC5008916.
  56. MacRae SL, Croken MM, Calder RB, Aliper A, Milholland B, White RR, Zhavoronkov A, Gladyshev VN, Seluanov A, Gorbunova V, Zhang ZD, Vijg J. DNA repair in species with extreme lifespan differences. Aging (Albany NY). 2015 Dec; 7(12):1171-84. PMID: 26729707; PMCID: PMC4712340.
  57. Tobe R, Carlson BA, Tsuji PA, Lee BJ, Gladyshev VN, Hatfield DL. Differences in Redox Regulatory Systems in Human Lung and Liver Tumors Suggest Different Avenues for Therapy. Cancers (Basel). 2015 Nov 10; 7(4):2262-76. PMID: 26569310; PMCID: PMC4695889.
  58. Zhou X, Seim I, Gladyshev VN. Convergent evolution of marine mammals is associated with distinct substitutions in common genes. Sci Rep. 2015 Nov 09; 5:16550. PMID: 26549748; PMCID: PMC4637874.
  59. Ma S, Lee SG, Kim EB, Park TJ, Seluanov A, Gorbunova V, Buffenstein R, Seravalli J, Gladyshev VN. Organization of the Mammalian Ionome According to Organ Origin, Lineage Specialization, and Longevity. Cell Rep. 2015 Nov 17; 13(7):1319-1326. PMID: 26549444; PMCID: PMC4771060.
  60. Bisio H, Bonilla M, Manta B, Graña M, Salzman V, Aguilar PS, Gladyshev VN, Comini MA, Salinas G. A New Class of Thioredoxin-Related Protein Able to Bind Iron-Sulfur Clusters. Antioxid Redox Signal. 2015 Oct 27. PMID: 26381228.
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  61. Turanov AA, Everley RA, Hybsier S, Renko K, Schomburg L, Gygi SP, Hatfield DL, Gladyshev VN. Regulation of Selenocysteine Content of Human Selenoprotein P by Dietary Selenium and Insertion of Cysteine in Place of Selenocysteine. PLoS One. 2015; 10(10):e0140353. PMID: 26452064; PMCID: PMC4599804.
  62. Kaya A, Ma S, Wasko B, Lee M, Kaeberlein M, Gladyshev VN. Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates. NPJ Aging Mech Dis. 2015; 1. PMID: 27030810.
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  63. Kaya A, Gerashchenko MV, Seim I, Labarre J, Toledano MB, Gladyshev VN. Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins. Proc Natl Acad Sci U S A. 2015 Aug 25; 112(34):10685-90. PMID: 26261310; PMCID: PMC4553801.
  64. Ma S, Yim SH, Lee SG, Kim EB, Lee SR, Chang KT, Buffenstein R, Lewis KN, Park TJ, Miller RA, Clish CB, Gladyshev VN. Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity. Cell Metab. 2015 Aug 04; 22(2):332-43. PMID: 26244935; PMCID: PMC4758382.
  65. Mariotti M, Santesmasses D, Capella-Gutierrez S, Mateo A, Arnan C, Johnson R, D'Aniello S, Yim SH, Gladyshev VN, Serras F, Corominas M, Gabaldón T, Guigó R. Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization. Genome Res. 2015 Sep; 25(9):1256-67. PMID: 26194102; PMCID: PMC4561486.
  66. Kaya A, Lee BC, Gladyshev VN. Regulation of protein function by reversible methionine oxidation and the role of selenoprotein MsrB1. Antioxid Redox Signal. 2015 Oct 01; 23(10):814-22. PMID: 26181576; PMCID: PMC4589106 [Available on 10/01/16].
  67. Gould NS, Evans P, Martínez-Acedo P, Marino SM, Gladyshev VN, Carroll KS, Ischiropoulos H. Site-Specific Proteomic Mapping Identifies Selectively Modified Regulatory Cysteine Residues in Functionally Distinct Protein Networks. Chem Biol. 2015 Jul 23; 22(7):965-75. PMID: 26165157; PMCID: PMC4515171.
  68. Kim MJ, Lee BC, Hwang KY, Gladyshev VN, Kim HY. Selenium utilization in thioredoxin and catalytic advantage provided by selenocysteine. Biochem Biophys Res Commun. 2015 Jun 12; 461(4):648-52. PMID: 25912135.
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  69. Tsuji PA, Carlson BA, Yoo MH, Naranjo-Suarez S, Xu XM, He Y, Asaki E, Seifried HE, Reinhold WC, Davis CD, Gladyshev VN, Hatfield DL. The 15kDa selenoprotein and thioredoxin reductase 1 promote colon cancer by different pathways. PLoS One. 2015; 10(4):e0124487. PMID: 25886253; PMCID: PMC4401539.
  70. Tarrago L, Péterfi Z, Lee BC, Michel T, Gladyshev VN. Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors. Nat Chem Biol. 2015 May; 11(5):332-8. PMID: 25799144; PMCID: PMC4402147.
  71. Bang J, Huh JH, Na JW, Lu Q, Carlson BA, Tobe R, Tsuji PA, Gladyshev VN, Hatfield DL, Lee BJ. Cell Proliferation and Motility Are Inhibited by G1 Phase Arrest in 15-kDa Selenoprotein-Deficient Chang Liver Cells. Mol Cells. 2015 May; 38(5):457-65. PMID: 25728752; PMCID: PMC4443288.
  72. Kaya A, Lobanov AV, Gladyshev VN. Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae. Aging Cell. 2015 Jun; 14(3):366-71. PMID: 25702753; PMCID: PMC4406665.
  73. Fushan AA, Turanov AA, Lee SG, Kim EB, Lobanov AV, Yim SH, Buffenstein R, Lee SR, Chang KT, Rhee H, Kim JS, Yang KS, Gladyshev VN. Gene expression defines natural changes in mammalian lifespan. Aging Cell. 2015 Jun; 14(3):352-65. PMID: 25677554; PMCID: PMC4406664.
  74. MacRae SL, Zhang Q, Lemetre C, Seim I, Calder RB, Hoeijmakers J, Suh Y, Gladyshev VN, Seluanov A, Gorbunova V, Vijg J, Zhang ZD. Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human. Aging Cell. 2015 Apr; 14(2):288-91. PMID: 25645816; PMCID: PMC4364841.
  75. Nakao LS, Everley RA, Marino SM, Lo SM, de Souza LE, Gygi SP, Gladyshev VN. Mechanism-based proteomic screening identifies targets of thioredoxin-like proteins. J Biol Chem. 2015 Feb 27; 290(9):5685-95. PMID: 25561728; PMCID: PMC4342480.
  76. Tian X, Azpurua J, Ke Z, Augereau A, Zhang ZD, Vijg J, Gladyshev VN, Gorbunova V, Seluanov A. INK4 locus of the tumor-resistant rodent, the naked mole rat, expresses a functional p15/p16 hybrid isoform. Proc Natl Acad Sci U S A. 2015 Jan 27; 112(4):1053-8. PMID: 25550505; PMCID: PMC4313802.
  77. Hine C, Harputlugil E, Zhang Y, Ruckenstuhl C, Lee BC, Brace L, Longchamp A, Treviño-Villarreal JH, Mejia P, Ozaki CK, Wang R, Gladyshev VN, Madeo F, Mair WB, Mitchell JR. Endogenous hydrogen sulfide production is essential for dietary restriction benefits. Cell. 2015 Jan 15; 160(1-2):132-44. PMID: 25542313; PMCID: PMC4297538.
  78. Bang J, Jang M, Huh JH, Na JW, Shim M, Carlson BA, Tobe R, Tsuji PA, Gladyshev VN, Hatfield DL, Lee BJ. Deficiency of the 15-kDa selenoprotein led to cytoskeleton remodeling and non-apoptotic membrane blebbing through a RhoA/ROCK pathway. Biochem Biophys Res Commun. 2015 Jan 24; 456(4):884-90. PMID: 25529450; PMCID: PMC4758352.
  79. Gladyshev VN. Selenium and Methionine Sulfoxide Reduction. Free Radic Biol Med. 2014 Oct; 75 Suppl 1:S8-9. PMID: 26461418.
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  80. Cornelis MC, Fornage M, Foy M, Xun P, Gladyshev VN, Morris S, Chasman DI, Hu FB, Rimm EB, Kraft P, Jordan JM, Mozaffarian D, He K. Genome-wide association study of selenium concentrations. Hum Mol Genet. 2015 Mar 01; 24(5):1469-77. PMID: 25343990.
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  81. Seim I, Ma S, Zhou X, Gerashchenko MV, Lee SG, Suydam R, George JC, Bickham JW, Gladyshev VN. The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal. Aging (Albany NY). 2014 Oct; 6(10):879-99. PMID: 25411232; PMCID: PMC4247388.
  82. Turanov AA, Shchedrina VA, Everley RA, Lobanov AV, Yim SH, Marino SM, Gygi SP, Hatfield DL, Gladyshev VN. Selenoprotein S is involved in maintenance and transport of multiprotein complexes. Biochem J. 2014 Sep 15; 462(3):555-65. PMID: 24897171.
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  83. Kaya A, Lobanov AV, Gerashchenko MV, Koren A, Fomenko DE, Koc A, Gladyshev VN. Thiol peroxidase deficiency leads to increased mutational load and decreased fitness in Saccharomyces cerevisiae. Genetics. 2014 Nov; 198(3):905-17. PMID: 25173844; PMCID: PMC4224179.
  84. Fang X, Seim I, Huang Z, Gerashchenko MV, Xiong Z, Turanov AA, Zhu Y, Lobanov AV, Fan D, Yim SH, Yao X, Ma S, Yang L, Lee SG, Kim EB, Bronson RT, Šumbera R, Buffenstein R, Zhou X, Krogh A, Park TJ, Zhang G, Wang J, Gladyshev VN. Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes. Cell Rep. 2014 Sep 11; 8(5):1354-64. PMID: 25176646; PMCID: PMC4350764.
  85. Gerashchenko MV, Gladyshev VN. Translation inhibitors cause abnormalities in ribosome profiling experiments. Nucleic Acids Res. 2014; 42(17):e134. PMID: 25056308; PMCID: PMC4176156.
  86. Guo C, Chen X, Song H, Maynard MA, Zhou Y, Lobanov AV, Gladyshev VN, Ganis JJ, Wiley D, Jugo RH, Lee NY, Castroneves LA, Zon LI, Scanlan TS, Feldman HA, Huang SA. Intrinsic expression of a multiexon type 3 deiodinase gene controls zebrafish embryo size. Endocrinology. 2014 Oct; 155(10):4069-80. PMID: 25004091; PMCID: PMC4164935.
  87. Labunskyy VM, Hatfield DL, Gladyshev VN. Selenoproteins: molecular pathways and physiological roles. Physiol Rev. 2014 Jul; 94(3):739-77. PMID: 24987004; PMCID: PMC4101630.
  88. Gorbunova V, Seluanov A, Zhang Z, Gladyshev VN, Vijg J. Comparative genetics of longevity and cancer: insights from long-lived rodents. Nat Rev Genet. 2014 Aug; 15(8):531-40. PMID: 24981598; PMCID: PMC4353926.
  89. Ables GP, Brown-Borg HM, Buffenstein R, Church CD, Elshorbagy AK, Gladyshev VN, Huang TH, Miller RA, Mitchell JR, Richie JP, Rogina B, Stipanuk MH, Orentreich DS, Orentreich N. The first international mini-symposium on methionine restriction and lifespan. Front Genet. 2014; 5:122. PMID: 24847356; PMCID: PMC4023024.
  90. Otero L, Romanelli-Cedrez L, Turanov AA, Gladyshev VN, Miranda-Vizuete A, Salinas G. Adjustments, extinction, and remains of selenocysteine incorporation machinery in the nematode lineage. RNA. 2014 Jul; 20(7):1023-34. PMID: 24817701; PMCID: PMC4114682.
  91. Avanesov AS, Ma S, Pierce KA, Yim SH, Lee BC, Clish CB, Gladyshev VN. Age- and diet-associated metabolome remodeling characterizes the aging process driven by damage accumulation. Elife. 2014 Apr 29; 3:e02077. PMID: 24843015; PMCID: PMC4003482.
  92. Labunskyy VM, Suzuki Y, Hanly TJ, Murao A, Roth FP, Gladyshev VN. The insertion Green Monster (iGM) method for expression of multiple exogenous genes in yeast. G3 (Bethesda). 2014 Apr 28; 4(7):1183-91. PMID: 24776987; PMCID: PMC4455768.
  93. Han SJ, Lee BC, Yim SH, Gladyshev VN, Lee SR. Characterization of mammalian selenoprotein o: a redox-active mitochondrial protein. PLoS One. 2014; 9(4):e95518. PMID: 24751718; PMCID: PMC3994087.
  94. Barroso M, Florindo C, Kalwa H, Silva Z, Turanov AA, Carlson BA, de Almeida IT, Blom HJ, Gladyshev VN, Hatfield DL, Michel T, Castro R, Loscalzo J, Handy DE. Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. J Biol Chem. 2014 May 30; 289(22):15350-62. PMID: 24719327; PMCID: PMC4140892.
  95. Lee BC, Kaya A, Ma S, Kim G, Gerashchenko MV, Yim SH, Hu Z, Harshman LG, Gladyshev VN. Methionine restriction extends lifespan of Drosophila melanogaster under conditions of low amino-acid status. Nat Commun. 2014 Apr 07; 5:3592. PMID: 24710037; PMCID: PMC4350766.
  96. Hatfield DL, Tsuji PA, Carlson BA, Gladyshev VN. Selenium and selenocysteine: roles in cancer, health, and development. Trends Biochem Sci. 2014 Mar; 39(3):112-20. PMID: 24485058.
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  97. Labunskyy VM, Gerashchenko MV, Delaney JR, Kaya A, Kennedy BK, Kaeberlein M, Gladyshev VN. Lifespan extension conferred by endoplasmic reticulum secretory pathway deficiency requires induction of the unfolded protein response. PLoS Genet. 2014 Jan; 10(1):e1004019. PMID: 24391512; PMCID: PMC3879150.
  98. Malinouski M, Hasan NM, Zhang Y, Seravalli J, Lin J, Avanesov A, Lutsenko S, Gladyshev VN. Genome-wide RNAi ionomics screen reveals new genes and regulation of human trace element metabolism. Nat Commun. 2014; 5:3301. PMID: 24522796.
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  99. Gladyshev VN. The free radical theory of aging is dead. Long live the damage theory! Antioxid Redox Signal. 2014 Feb 01; 20(4):727-31. PMID: 24159899; PMCID: PMC3901353.
  100. Romagné F, Santesmasses D, White L, Sarangi GK, Mariotti M, Hübler R, Weihmann A, Parra G, Gladyshev VN, Guigó R, Castellano S. SelenoDB 2.0: annotation of selenoprotein genes in animals and their genetic diversity in humans. Nucleic Acids Res. 2014 Jan; 42(Database issue):D437-43. PMID: 24194593; PMCID: PMC3965025.
  101. Yoo MH, Carlson BA, Gladyshev VN, Hatfield DL. Abrogated thioredoxin system causes increased sensitivity to TNF-a-induced apoptosis via enrichment of p-ERK 1/2 in the nucleus. PLoS One. 2013; 8(9):e71427. PMID: 24039713; PMCID: PMC3765418.
  102. Naranjo-Suarez S, Carlson BA, Tobe R, Yoo MH, Tsuji PA, Gladyshev VN, Hatfield DL. Regulation of HIF-1a activity by overexpression of thioredoxin is independent of thioredoxin reductase status. Mol Cells. 2013 Aug; 36(2):151-7. PMID: 23912593; PMCID: PMC3887957.
  103. Lee BC, Péterfi Z, Hoffmann FW, Moore RE, Kaya A, Avanesov A, Tarrago L, Zhou Y, Weerapana E, Fomenko DE, Hoffmann PR, Gladyshev VN. MsrB1 and MICALs regulate actin assembly and macrophage function via reversible stereoselective methionine oxidation. Mol Cell. 2013 Aug 08; 51(3):397-404. PMID: 23911929; PMCID: PMC4262529.
  104. Mariotti M, Lobanov AV, Guigo R, Gladyshev VN. SECISearch3 and Seblastian: new tools for prediction of SECIS elements and selenoproteins. Nucleic Acids Res. 2013 Aug; 41(15):e149. PMID: 23783574; PMCID: PMC3753652.
  105. Gladyshev VN. The origin of aging: imperfectness-driven non-random damage defines the aging process and control of lifespan. Trends Genet. 2013 Sep; 29(9):506-12. PMID: 23769208; PMCID: PMC3804915.
  106. Le DT, Tarrago L, Watanabe Y, Kaya A, Lee BC, Tran U, Nishiyama R, Fomenko DE, Gladyshev VN, Tran LS. Diversity of plant methionine sulfoxide reductases B and evolution of a form specific for free methionine sulfoxide. PLoS One. 2013; 8(6):e65637. PMID: 23776515; PMCID: PMC3680461.
  107. Turanov AA, Lobanov AV, Hatfield DL, Gladyshev VN. UGA codon position-dependent incorporation of selenocysteine into mammalian selenoproteins. Nucleic Acids Res. 2013 Aug; 41(14):6952-9. PMID: 23716634; PMCID: PMC3737529.
  108. Tobe R, Naranjo-Suarez S, Everley RA, Carlson BA, Turanov AA, Tsuji PA, Yoo MH, Gygi SP, Gladyshev VN, Hatfield DL. High error rates in selenocysteine insertion in mammalian cells treated with the antibiotic doxycycline, chloramphenicol, or geneticin. J Biol Chem. 2013 May 24; 288(21):14709-15. PMID: 23589299; PMCID: PMC3663496.
  109. Gobler CJ, Lobanov AV, Tang YZ, Turanov AA, Zhang Y, Doblin M, Taylor GT, Sañudo-Wilhelmy SA, Grigoriev IV, Gladyshev VN. The central role of selenium in the biochemistry and ecology of the harmful pelagophyte, Aureococcus anophagefferens. ISME J. 2013 Jul; 7(7):1333-43. PMID: 23466703.
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  110. Moustafa ME, Carlson BA, Anver MR, Bobe G, Zhong N, Ward JM, Perella CM, Hoffmann VJ, Rogers K, Combs GF, Schweizer U, Merlino G, Gladyshev VN, Hatfield DL. Selenium and selenoprotein deficiencies induce widespread pyogranuloma formation in mice, while high levels of dietary selenium decrease liver tumor size driven by TGFa. PLoS One. 2013; 8(2):e57389. PMID: 23460847; PMCID: PMC3583866.
  111. Kasaikina MV, Turanov AA, Avanesov A, Schweizer U, Seeher S, Bronson RT, Novoselov SN, Carlson BA, Hatfield DL, Gladyshev VN. Contrasting roles of dietary selenium and selenoproteins in chemically induced hepatocarcinogenesis. Carcinogenesis. 2013 May; 34(5):1089-95. PMID: 23389288; PMCID: PMC3643414.
  112. Gladyshev VN, Zhang Y. Comparative genomics analysis of the metallomes. Met Ions Life Sci. 2013; 12:529-80. PMID: 23595683.
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  113. Seim I, Fang X, Xiong Z, Lobanov AV, Huang Z, Ma S, Feng Y, Turanov AA, Zhu Y, Lenz TL, Gerashchenko MV, Fan D, Hee Yim S, Yao X, Jordan D, Xiong Y, Ma Y, Lyapunov AN, Chen G, Kulakova OI, Sun Y, Lee SG, Bronson RT, Moskalev AA, Sunyaev SR, Zhang G, Krogh A, Wang J, Gladyshev VN. Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii. Nat Commun. 2013; 4:2212. PMID: 23962925; PMCID: PMC3753542.
  114. Dobrovolska O, Shumilina E, Gladyshev VN, Dikiy A. Structural analysis of glutaredoxin domain of Mus musculus thioredoxin glutathione reductase. PLoS One. 2012; 7(12):e52914. PMID: 23300818; PMCID: PMC3530482.
  115. Hondal RJ, Marino SM, Gladyshev VN. Selenocysteine in thiol/disulfide-like exchange reactions. Antioxid Redox Signal. 2013 May 01; 18(13):1675-89. PMID: 23121622; PMCID: PMC3613276.
  116. Tsuji PA, Carlson BA, Naranjo-Suarez S, Yoo MH, Xu XM, Fomenko DE, Gladyshev VN, Hatfield DL, Davis CD. Knockout of the 15 kDa selenoprotein protects against chemically-induced aberrant crypt formation in mice. PLoS One. 2012; 7(12):e50574. PMID: 23226526; PMCID: PMC3514276.
  117. Liang X, Kaya A, Zhang Y, Le DT, Hua D, Gladyshev VN. Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins. BMC Biochem. 2012 Oct 23; 13:21. PMID: 23088625; PMCID: PMC3514235.
  118. Gerashchenko MV, Lobanov AV, Gladyshev VN. Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17394-9. PMID: 23045643; PMCID: PMC3491468.
  119. Williams DL, Bonilla M, Gladyshev VN, Salinas G. Thioredoxin glutathione reductase-dependent redox networks in platyhelminth parasites. Antioxid Redox Signal. 2013 Sep 01; 19(7):735-45. PMID: 22909029; PMCID: PMC3739949.
  120. Tarrago L, Gladyshev VN. Recharging oxidative protein repair: catalysis by methionine sulfoxide reductases towards their amino acid, protein, and model substrates. Biochemistry (Mosc). 2012 Oct; 77(10):1097-107. PMID: 23157290.
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  121. Labunskyy VM, Gladyshev VN. Role of reactive oxygen species-mediated signaling in aging. Antioxid Redox Signal. 2013 Oct 20; 19(12):1362-72. PMID: 22901002; PMCID: PMC3791051.
  122. Gladyshev VN. On the cause of aging and control of lifespan: heterogeneity leads to inevitable damage accumulation, causing aging; control of damage composition and rate of accumulation define lifespan. Bioessays. 2012 Nov; 34(11):925-9. PMID: 22915358; PMCID: PMC3804916.
  123. Tobe R, Yoo MH, Fradejas N, Carlson BA, Calvo S, Gladyshev VN, Hatfield DL. Thioredoxin reductase 1 deficiency enhances selenite toxicity in cancer cells via a thioredoxin-independent mechanism. Biochem J. 2012 Aug 01; 445(3):423-30. PMID: 22594686.
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  124. Carlson BA, Yoo MH, Tobe R, Mueller C, Naranjo-Suarez S, Hoffmann VJ, Gladyshev VN, Hatfield DL. Thioredoxin reductase 1 protects against chemically induced hepatocarcinogenesis via control of cellular redox homeostasis. Carcinogenesis. 2012 Sep; 33(9):1806-13. PMID: 22791808; PMCID: PMC3514905.
  125. Tarrago L, Kaya A, Weerapana E, Marino SM, Gladyshev VN. Methionine sulfoxide reductases preferentially reduce unfolded oxidized proteins and protect cells from oxidative protein unfolding. J Biol Chem. 2012 Jul 13; 287(29):24448-59. PMID: 22628550; PMCID: PMC3397870.
  126. Anisimov VN, Bartke A, Barzilai N, Batin MA, Blagosklonny MV, Brown-Borg H, Budovskaya Y, Campisi J, Friguet B, Fraifeld V, Franceschi C, Gems D, Gladyshev V, Gorbunova V, Gudkov AV, Kennedy B, Konovalenko M, Kraemer B, Moskalev A, Petropoulos I, Pasyukova E, Rattan S, Rogina B, Seluanov A, Shaposhnikov M, Shmookler Reis R, Tavernarakis N, Vijg J, Yashin A, Zimniak P. The second international conference "genetics of aging and longevity". Aging (Albany NY). 2012 May; 4(5):305-17. PMID: 22661237.
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  127. Ross F, Hernández P, Porcal W, López GV, Cerecetto H, González M, Basika T, Carmona C, Fló M, Maggioli G, Bonilla M, Gladyshev VN, Boiani M, Salinas G. Identification of thioredoxin glutathione reductase inhibitors that kill cestode and trematode parasites. PLoS One. 2012; 7(4):e35033. PMID: 22536349; PMCID: PMC3335049.
  128. Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN. Composition and evolution of the vertebrate and mammalian selenoproteomes. PLoS One. 2012; 7(3):e33066. PMID: 22479358; PMCID: PMC3316567.
  129. Kasaikina MV, Hatfield DL, Gladyshev VN. Understanding selenoprotein function and regulation through the use of rodent models. Biochim Biophys Acta. 2012 Sep; 1823(9):1633-42. PMID: 22440326; PMCID: PMC3408893.
  130. Vinogradov DV, Tsoi OV, Zaika AV, Lobanov AV, Turanov AA, Gladyshev VN, Gel'fand MS. [Draft macronuclear genome of a ciliate Euplotes crassus]. Mol Biol (Mosk). 2012 Mar-Apr; 46(2):361-6. PMID: 22670532.
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  131. Naranjo-Suarez S, Carlson BA, Tsuji PA, Yoo MH, Gladyshev VN, Hatfield DL. HIF-independent regulation of thioredoxin reductase 1 contributes to the high levels of reactive oxygen species induced by hypoxia. PLoS One. 2012; 7(2):e30470. PMID: 22348009; PMCID: PMC3278416.
  132. Marino SM, Gladyshev VN. Analysis and functional prediction of reactive cysteine residues. J Biol Chem. 2012 Feb 10; 287(7):4419-25. PMID: 22157013; PMCID: PMC3281665.
  133. Gladyshev VN, Zhang G, Wang J. The naked mole rat genome: understanding aging through genome analysis. Aging (Albany NY). 2011 Dec; 3(12):1124. PMID: 22199030; PMCID: PMC3273891.
  134. Fomenko DE, Gladyshev VN. Comparative genomics of thiol oxidoreductases reveals widespread and essential functions of thiol-based redox control of cellular processes. Antioxid Redox Signal. 2012 Feb 01; 16(3):193-201. PMID: 21902454; PMCID: PMC3234660.
  135. Malinouski M, Kehr S, Finney L, Vogt S, Carlson BA, Seravalli J, Jin R, Handy DE, Park TJ, Loscalzo J, Hatfield DL, Gladyshev VN. High-resolution imaging of selenium in kidneys: a localized selenium pool associated with glutathione peroxidase 3. Antioxid Redox Signal. 2012 Feb 01; 16(3):185-92. PMID: 21854231; PMCID: PMC3234661.
  136. Uluisik I, Kaya A, Fomenko DE, Karakaya HC, Carlson BA, Gladyshev VN, Koc A. Boron stress activates the general amino acid control mechanism and inhibits protein synthesis. PLoS One. 2011; 6(11):e27772. PMID: 22114689; PMCID: PMC3219688.
  137. Shchedrina VA, Everley RA, Zhang Y, Gygi SP, Hatfield DL, Gladyshev VN. Selenoprotein K binds multiprotein complexes and is involved in the regulation of endoplasmic reticulum homeostasis. J Biol Chem. 2011 Dec 16; 286(50):42937-48. PMID: 22016385; PMCID: PMC3234841.
  138. Kim EB, Fang X, Fushan AA, Huang Z, Lobanov AV, Han L, Marino SM, Sun X, Turanov AA, Yang P, Yim SH, Zhao X, Kasaikina MV, Stoletzki N, Peng C, Polak P, Xiong Z, Kiezun A, Zhu Y, Chen Y, Kryukov GV, Zhang Q, Peshkin L, Yang L, Bronson RT, Buffenstein R, Wang B, Han C, Li Q, Chen L, Zhao W, Sunyaev SR, Park TJ, Zhang G, Wang J, Gladyshev VN. Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature. 2011 Oct 12; 479(7372):223-7. PMID: 21993625; PMCID: PMC3319411.
  139. Carlson BA, Yoo MH, Conrad M, Gladyshev VN, Hatfield DL, Park JM. Protein kinase-regulated expression and immune function of thioredoxin reductase 1 in mouse macrophages. Mol Immunol. 2011 Oct; 49(1-2):311-6. PMID: 21943784; PMCID: PMC3205301.
  140. Shumilina E, Soldà A, Gerashchenko M, Gladyshev VN, Dikiy A. ¹H, ¹³C, and ¹5N NMR resonance assignments of reduced full length and shortened forms of the Grx domain of Mus musculus TGR. Biomol NMR Assign. 2012 Apr; 6(1):103-7. PMID: 21901408; PMCID: PMC3640641.
  141. Aachmann FL, Kwak GH, Del Conte R, Kim HY, Gladyshev VN, Dikiy A. Structural and biochemical analysis of mammalian methionine sulfoxide reductase B2. Proteins. 2011 Nov; 79(11):3123-31. PMID: 21989933; PMCID: PMC3193156.
  142. Lee BC, Fomenko DE, Gladyshev VN. Selective reduction of methylsulfinyl-containing compounds by mammalian MsrA suggests a strategy for improved drug efficacy. ACS Chem Biol. 2011 Oct 21; 6(10):1029-35. PMID: 21823615; PMCID: PMC3311536.
  143. Yim SH, Kim YJ, Oh SY, Fujii J, Zhang Y, Gladyshev VN, Rhee SG. Identification and characterization of alternatively transcribed form of peroxiredoxin IV gene that is specifically expressed in spermatids of postpubertal mouse testis. J Biol Chem. 2011 Nov 11; 286(45):39002-12. PMID: 21835919; PMCID: PMC3234725.
  144. Kasaikina MV, Fomenko DE, Labunskyy VM, Lachke SA, Qiu W, Moncaster JA, Zhang J, Wojnarowicz MW, Natarajan SK, Malinouski M, Schweizer U, Tsuji PA, Carlson BA, Maas RL, Lou MF, Goldstein LE, Hatfield DL, Gladyshev VN. Roles of the 15-kDa selenoprotein (Sep15) in redox homeostasis and cataract development revealed by the analysis of Sep 15 knockout mice. J Biol Chem. 2011 Sep 23; 286(38):33203-12. PMID: 21768092; PMCID: PMC3190948.
  145. Wu C, Parrott AM, Fu C, Liu T, Marino SM, Gladyshev VN, Jain MR, Baykal AT, Li Q, Oka S, Sadoshima J, Beuve A, Simmons WJ, Li H. Thioredoxin 1-mediated post-translational modifications: reduction, transnitrosylation, denitrosylation, and related proteomics methodologies. Antioxid Redox Signal. 2011 Nov 01; 15(9):2565-604. PMID: 21453190; PMCID: PMC3176348.
  146. Shchedrina VA, Kabil H, Vorbruggen G, Lee BC, Turanov AA, Hirosawa-Takamori M, Kim HY, Harshman LG, Hatfield DL, Gladyshev VN. Analyses of fruit flies that do not express selenoproteins or express the mouse selenoprotein, methionine sulfoxide reductase B1, reveal a role of selenoproteins in stress resistance. J Biol Chem. 2011 Aug 26; 286(34):29449-61. PMID: 21622567; PMCID: PMC3190985.
  147. Kim JY, Carlson BA, Xu XM, Zeng Y, Chen S, Gladyshev VN, Lee BJ, Hatfield DL. Inhibition of selenocysteine tRNA[Ser]Sec aminoacylation provides evidence that aminoacylation is required for regulatory methylation of this tRNA. Biochem Biophys Res Commun. 2011 Jun 17; 409(4):814-9. PMID: 21624347.
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  148. Zhang Y, Gladyshev VN. Comparative genomics of trace element dependence in biology. J Biol Chem. 2011 Jul 08; 286(27):23623-9. PMID: 21566146; PMCID: PMC3129141.
  149. Zhang Y, Rump S, Gladyshev VN. Comparative Genomics and Evolution of Molybdenum Utilization. Coord Chem Rev. 2011 May; 255(9-10):1206-1217. PMID: 22451726.
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  150. Marino SM, Gladyshev VN. Redox biology: computational approaches to the investigation of functional cysteine residues. Antioxid Redox Signal. 2011 Jul 01; 15(1):135-46. PMID: 20812876; PMCID: PMC3110093.
  151. Kasaikina MV, Kravtsova MA, Lee BC, Seravalli J, Peterson DA, Walter J, Legge R, Benson AK, Hatfield DL, Gladyshev VN. Dietary selenium affects host selenoproteome expression by influencing the gut microbiota. FASEB J. 2011 Jul; 25(7):2492-9. PMID: 21493887; PMCID: PMC3114522.
  152. Labunskyy VM, Lee BC, Handy DE, Loscalzo J, Hatfield DL, Gladyshev VN. Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice. Antioxid Redox Signal. 2011 Jun 15; 14(12):2327-36. PMID: 21194350; PMCID: PMC3096499.
  153. Turanov AA, Xu XM, Carlson BA, Yoo MH, Gladyshev VN, Hatfield DL. Biosynthesis of selenocysteine, the 21st amino acid in the genetic code, and a novel pathway for cysteine biosynthesis. Adv Nutr. 2011 Mar; 2(2):122-8. PMID: 22332041; PMCID: PMC3065758.
  154. Lee BC, Lobanov AV, Marino SM, Kaya A, Seravalli J, Hatfield DL, Gladyshev VN. A 4-selenocysteine, 2-selenocysteine insertion sequence (SECIS) element methionine sulfoxide reductase from Metridium senile reveals a non-catalytic function of selenocysteines. J Biol Chem. 2011 May 27; 286(21):18747-55. PMID: 21393246; PMCID: PMC3099691.
  155. Kasaikina MV, Lobanov AV, Malinouski MY, Lee BC, Seravalli J, Fomenko DE, Turanov AA, Finney L, Vogt S, Park TJ, Miller RA, Hatfield DL, Gladyshev VN. Reduced utilization of selenium by naked mole rats due to a specific defect in GPx1 expression. J Biol Chem. 2011 May 13; 286(19):17005-14. PMID: 21372135; PMCID: PMC3089545.
  156. Gobler CJ, Berry DL, Dyhrman ST, Wilhelm SW, Salamov A, Lobanov AV, Zhang Y, Collier JL, Wurch LL, Kustka AB, Dill BD, Shah M, VerBerkmoes NC, Kuo A, Terry A, Pangilinan J, Lindquist EA, Lucas S, Paulsen IT, Hattenrath-Lehmann TK, Talmage SC, Walker EA, Koch F, Burson AM, Marcoval MA, Tang YZ, Lecleir GR, Coyne KJ, Berg GM, Bertrand EM, Saito MA, Gladyshev VN, Grigoriev IV. Niche of harmful alga Aureococcus anophagefferens revealed through ecogenomics. Proc Natl Acad Sci U S A. 2011 Mar 15; 108(11):4352-7. PMID: 21368207.
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  157. Marino SM, Gladyshev VN. Proteomics: mapping reactive cysteines. Nat Chem Biol. 2011 Feb; 7(2):72-3. PMID: 21245858.
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  158. Fomenko DE, Koc A, Agisheva N, Jacobsen M, Kaya A, Malinouski M, Rutherford JC, Siu KL, Jin DY, Winge DR, Gladyshev VN. Thiol peroxidases mediate specific genome-wide regulation of gene expression in response to hydrogen peroxide. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2729-34. PMID: 21282621; PMCID: PMC3041109.
  159. Malinouski M, Zhou Y, Belousov VV, Hatfield DL, Gladyshev VN. Hydrogen peroxide probes directed to different cellular compartments. PLoS One. 2011 Jan 21; 6(1):e14564. PMID: 21283738; PMCID: PMC3024970.
  160. Suzuki Y, St Onge RP, Mani R, King OD, Heilbut A, Labunskyy VM, Chen W, Pham L, Zhang LV, Tong AH, Nislow C, Giaever G, Gladyshev VN, Vidal M, Schow P, Lehár J, Roth FP. Knocking out multigene redundancies via cycles of sexual assortment and fluorescence selection. Nat Methods. 2011 Feb; 8(2):159-64. PMID: 21217751; PMCID: PMC3076670.
  161. Kim MJ, Lee BC, Jeong J, Lee KJ, Hwang KY, Gladyshev VN, Kim HY. Tandem use of selenocysteine: adaptation of a selenoprotein glutaredoxin for reduction of selenoprotein methionine sulfoxide reductase. Mol Microbiol. 2011 Mar; 79(5):1194-203. PMID: 21210868; PMCID: PMC3062254.
  162. Ahmed ZM, Yousaf R, Lee BC, Khan SN, Lee S, Lee K, Husnain T, Rehman AU, Bonneux S, Ansar M, Ahmad W, Leal SM, Gladyshev VN, Belyantseva IA, Van Camp G, Riazuddin S, Friedman TB, Riazuddin S. Functional null mutations of MSRB3 encoding methionine sulfoxide reductase are associated with human deafness DFNB74. Am J Hum Genet. 2011 Jan 07; 88(1):19-29. PMID: 21185009; PMCID: PMC3014371.
  163. Xu XM, Turanov AA, Carlson BA, Yoo MH, Everley RA, Nandakumar R, Sorokina I, Gygi SP, Gladyshev VN, Hatfield DL. Targeted insertion of cysteine by decoding UGA codons with mammalian selenocysteine machinery. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21430-4. PMID: 21115847; PMCID: PMC3003055.
  164. Lee BC, Gladyshev VN. The biological significance of methionine sulfoxide stereochemistry. Free Radic Biol Med. 2011 Jan 15; 50(2):221-7. PMID: 21075204; PMCID: PMC3311537.
  165. Bonilla M, Denicola A, Marino SM, Gladyshev VN, Salinas G. Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation. J Biol Chem. 2011 Feb 18; 286(7):4959-67. PMID: 21051543; PMCID: PMC3037608.
  166. Marino SM, Gladyshev VN. Cysteine function governs its conservation and degeneration and restricts its utilization on protein surfaces. J Mol Biol. 2010 Dec 17; 404(5):902-16. PMID: 20950627; PMCID: PMC3061813.
  167. Hacioglu E, Esmer I, Fomenko DE, Gladyshev VN, Koc A. The roles of thiol oxidoreductases in yeast replicative aging. Mech Ageing Dev. 2010 Nov-Dec; 131(11-12):692-9. PMID: 20934449; PMCID: PMC3311284.
  168. Kaya A, Koc A, Lee BC, Fomenko DE, Rederstorff M, Krol A, Lescure A, Gladyshev VN. Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeast. Biochemistry. 2010 Oct 05; 49(39):8618-25. PMID: 20799725; PMCID: PMC3061818.
  169. Marino SM, Li Y, Fomenko DE, Agisheva N, Cerny RL, Gladyshev VN. Characterization of surface-exposed reactive cysteine residues in Saccharomyces cerevisiae. Biochemistry. 2010 Sep 07; 49(35):7709-21. PMID: 20698499; PMCID: PMC3061811.
  170. Turanov AA, Kehr S, Marino SM, Yoo MH, Carlson BA, Hatfield DL, Gladyshev VN. Mammalian thioredoxin reductase 1: roles in redox homoeostasis and characterization of cellular targets. Biochem J. 2010 Sep 01; 430(2):285-93. PMID: 20536427.
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  171. Sengupta A, Lichti UF, Carlson BA, Ryscavage AO, Gladyshev VN, Yuspa SH, Hatfield DL. Selenoproteins are essential for proper keratinocyte function and skin development. PLoS One. 2010 Aug 18; 5(8):e12249. PMID: 20805887; PMCID: PMC2923614.
  172. Lobanov AV, Turanov AA, Hatfield DL, Gladyshev VN. Dual functions of codons in the genetic code. Crit Rev Biochem Mol Biol. 2010 Aug; 45(4):257-65. PMID: 20446809; PMCID: PMC3311535.
  173. Liang X, Fomenko DE, Hua D, Kaya A, Gladyshev VN. Diversity of protein and mRNA forms of mammalian methionine sulfoxide reductase B1 due to intronization and protein processing. PLoS One. 2010 Jul 09; 5(7):e11497. PMID: 20634897; PMCID: PMC2901347.
  174. Aachmann FL, Sal LS, Kim HY, Marino SM, Gladyshev VN, Dikiy A. Insights into function, catalytic mechanism, and fold evolution of selenoprotein methionine sulfoxide reductase B1 through structural analysis. J Biol Chem. 2010 Oct 22; 285(43):33315-23. PMID: 20605785; PMCID: PMC2963413.
  175. Carlson BA, Yoo MH, Shrimali RK, Irons R, Gladyshev VN, Hatfield DL, Park JM. Role of selenium-containing proteins in T-cell and macrophage function. Proc Nutr Soc. 2010 Aug; 69(3):300-10. PMID: 20576203; PMCID: PMC3169015.
  176. Turanov AA, Hatfield DL, Gladyshev VN. Characterization of protein targets of mammalian thioredoxin reductases. Methods Enzymol. 2010; 474:245-54. PMID: 20609914; PMCID: PMC3088097.
  177. Yoo MH, Carlson BA, Tsuji P, Irons R, Gladyshev VN, Hatfield DL. Alteration of thioredoxin reductase 1 levels in elucidating cancer etiology. Methods Enzymol. 2010; 474:255-75. PMID: 20609915; PMCID: PMC3088101.
  178. Irons R, Tsuji PA, Carlson BA, Ouyang P, Yoo MH, Xu XM, Hatfield DL, Gladyshev VN, Davis CD. Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and metastasis of colon cancer cells. Cancer Prev Res (Phila). 2010 May; 3(5):630-9. PMID: 20388823.
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  179. Otero L, Bonilla M, Protasio AV, Fernández C, Gladyshev VN, Salinas G. Thioredoxin and glutathione systems differ in parasitic and free-living platyhelminths. BMC Genomics. 2010 Apr 13; 11:237. PMID: 20385027; PMCID: PMC2873472.
  180. Shchedrina VA, Zhang Y, Labunskyy VM, Hatfield DL, Gladyshev VN. Structure-function relations, physiological roles, and evolution of mammalian ER-resident selenoproteins. Antioxid Redox Signal. 2010 Apr 01; 12(7):839-49. PMID: 19747065; PMCID: PMC2864662.
  181. Yoo MH, Gu X, Xu XM, Kim JY, Carlson BA, Patterson AD, Cai H, Gladyshev VN, Hatfield DL. Delineating the role of glutathione peroxidase 4 in protecting cells against lipid hydroperoxide damage and in Alzheimer's disease. Antioxid Redox Signal. 2010 Apr 01; 12(7):819-27. PMID: 19769463; PMCID: PMC2861544.
  182. Novoselov SV, Kim HY, Hua D, Lee BC, Astle CM, Harrison DE, Friguet B, Moustafa ME, Carlson BA, Hatfield DL, Gladyshev VN. Regulation of selenoproteins and methionine sulfoxide reductases A and B1 by age, calorie restriction, and dietary selenium in mice. Antioxid Redox Signal. 2010 Apr 01; 12(7):829-38. PMID: 19769460; PMCID: PMC2864656.
  183. Zhang Y, Gladyshev VN. dbTEU: a protein database of trace element utilization. Bioinformatics. 2010 Mar 01; 26(5):700-2. PMID: 20053843; PMCID: PMC2828109.
  184. Gerashchenko MV, Su D, Gladyshev VN. CUG start codon generates thioredoxin/glutathione reductase isoforms in mouse testes. J Biol Chem. 2010 Feb 12; 285(7):4595-602. PMID: 20018845; PMCID: PMC2836064.
  185. Sengupta A, Carlson BA, Labunskyy VM, Gladyshev VN, Hatfield DL. Selenoprotein T deficiency alters cell adhesion and elevates selenoprotein W expression in murine fibroblast cells. Biochem Cell Biol. 2009 Dec; 87(6):953-61. PMID: 19935881.
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  186. Zhang Y, Gladyshev VN. General trends in trace element utilization revealed by comparative genomic analyses of Co, Cu, Mo, Ni, and Se. J Biol Chem. 2010 Jan 29; 285(5):3393-405. PMID: 19887375; PMCID: PMC2823458.
  187. Carlson BA, Yoo MH, Sano Y, Sengupta A, Kim JY, Irons R, Gladyshev VN, Hatfield DL, Park JM. Selenoproteins regulate macrophage invasiveness and extracellular matrix-related gene expression. BMC Immunol. 2009 Oct 28; 10:57. PMID: 19863805; PMCID: PMC2774298.
  188. Marino SM, Gladyshev VN. Structural analysis of cysteine S-nitrosylation: a modified acid-based motif and the emerging role of trans-nitrosylation. J Mol Biol. 2010 Jan 29; 395(4):844-59. PMID: 19854201; PMCID: PMC3061812.
  189. Zhang Y, Gladyshev VN. Comparative genomics of trace elements: emerging dynamic view of trace element utilization and function. Chem Rev. 2009 Oct; 109(10):4828-61. PMID: 19459624.
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  190. Jin BY, Sartoretto JL, Gladyshev VN, Michel T. Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17343-8. PMID: 19805165; PMCID: PMC2762681.
  191. Bekaert M, Firth AE, Zhang Y, Gladyshev VN, Atkins JF, Baranov PV. Recode-2: new design, new search tools, and many more genes. Nucleic Acids Res. 2010 Jan; 38(Database issue):D69-74. PMID: 19783826; PMCID: PMC2808893.
  192. Carlson BA, Yoo MH, Tsuji PA, Gladyshev VN, Hatfield DL. Mouse models targeting selenocysteine tRNA expression for elucidating the role of selenoproteins in health and development. Molecules. 2009 Sep 10; 14(9):3509-27. PMID: 19783940.
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  193. Labunskyy VM, Yoo MH, Hatfield DL, Gladyshev VN. Sep15, a thioredoxin-like selenoprotein, is involved in the unfolded protein response and differentially regulated by adaptive and acute ER stresses. Biochemistry. 2009 Sep 08; 48(35):8458-65. PMID: 19650649; PMCID: PMC2778599.
  194. Xu XM, Yoo MH, Carlson BA, Gladyshev VN, Hatfield DL. Simultaneous knockdown of the expression of two genes using multiple shRNAs and subsequent knock-in of their expression. Nat Protoc. 2009; 4(9):1338-48. PMID: 19713955.
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  195. Lobanov AV, Hatfield DL, Gladyshev VN. Eukaryotic selenoproteins and selenoproteomes. Biochim Biophys Acta. 2009 Nov; 1790(11):1424-8. PMID: 19477234.
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  196. Marino SM, Gladyshev VN. A structure-based approach for detection of thiol oxidoreductases and their catalytic redox-active cysteine residues. PLoS Comput Biol. 2009 May; 5(5):e1000383. PMID: 19424433; PMCID: PMC2673044.
  197. Lee BC, Dikiy A, Kim HY, Gladyshev VN. Functions and evolution of selenoprotein methionine sulfoxide reductases. Biochim Biophys Acta. 2009 Nov; 1790(11):1471-7. PMID: 19406207; PMCID: PMC3062201.
  198. Kaya A, Karakaya HC, Fomenko DE, Gladyshev VN, Koc A. Identification of a novel system for boron transport: Atr1 is a main boron exporter in yeast. Mol Cell Biol. 2009 Jul; 29(13):3665-74. PMID: 19414602; PMCID: PMC2698749.
  199. Shchedrina VA, Vorbrüggen G, Lee BC, Kim HY, Kabil H, Harshman LG, Gladyshev VN. Overexpression of methionine-R-sulfoxide reductases has no influence on fruit fly aging. Mech Ageing Dev. 2009 Jul; 130(7):429-43. PMID: 19409408; PMCID: PMC3088106.
  200. Kehr S, Malinouski M, Finney L, Vogt S, Labunskyy VM, Kasaikina MV, Carlson BA, Zhou Y, Hatfield DL, Gladyshev VN. X-ray fluorescence microscopy reveals the role of selenium in spermatogenesis. J Mol Biol. 2009 Jun 26; 389(5):808-18. PMID: 19379757; PMCID: PMC2778597.
  201. Hatfield DL, Yoo MH, Carlson BA, Gladyshev VN. Selenoproteins that function in cancer prevention and promotion. Biochim Biophys Acta. 2009 Nov; 1790(11):1541-5. PMID: 19272412.
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  202. Kim HY, Zhang Y, Lee BC, Kim JR, Gladyshev VN. The selenoproteome of Clostridium sp. OhILAs: characterization of anaerobic bacterial selenoprotein methionine sulfoxide reductase A. Proteins. 2009 Mar; 74(4):1008-17. PMID: 18767149; PMCID: PMC2671064.
  203. Carlson BA, Schweizer U, Perella C, Shrimali RK, Feigenbaum L, Shen L, Speransky S, Floss T, Jeong SJ, Watts J, Hoffmann V, Combs GF, Gladyshev VN, Hatfield DL. The selenocysteine tRNA STAF-binding region is essential for adequate selenocysteine tRNA status, selenoprotein expression and early age survival of mice. Biochem J. 2009 Feb 15; 418(1):61-71. PMID: 18973473; PMCID: PMC2752860.
  204. Zhang Y, Rodionov DA, Gelfand MS, Gladyshev VN. Comparative genomic analyses of nickel, cobalt and vitamin B12 utilization. BMC Genomics. 2009 Feb 10; 10:78. PMID: 19208259; PMCID: PMC2667541.
  205. Hatfield DL, Gladyshev VN. The Outcome of Selenium and Vitamin E Cancer Prevention Trial (SELECT) reveals the need for better understanding of selenium biology. Mol Interv. 2009 Feb; 9(1):18-21. PMID: 19299660.
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  206. Turanov AA, Lobanov AV, Fomenko DE, Morrison HG, Sogin ML, Klobutcher LA, Hatfield DL, Gladyshev VN. Genetic code supports targeted insertion of two amino acids by one codon. Science. 2009 Jan 09; 323(5911):259-61. PMID: 19131629.
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  207. Le DT, Lee BC, Marino SM, Zhang Y, Fomenko DE, Kaya A, Hacioglu E, Kwak GH, Koc A, Kim HY, Gladyshev VN. Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiae. J Biol Chem. 2009 Feb 13; 284(7):4354-64. PMID: 19049972; PMCID: PMC2640979.
  208. Papp LV, Wang J, Kennedy D, Boucher D, Zhang Y, Gladyshev VN, Singh RN, Khanna KK. Functional characterization of alternatively spliced human SECISBP2 transcript variants. Nucleic Acids Res. 2008 Dec; 36(22):7192-206. PMID: 19004874; PMCID: PMC2602786.
  209. Fomenko DE, Novoselov SV, Natarajan SK, Lee BC, Koc A, Carlson BA, Lee TH, Kim HY, Hatfield DL, Gladyshev VN. MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein form. J Biol Chem. 2009 Feb 27; 284(9):5986-93. PMID: 18990697; PMCID: PMC2645841.
  210. Breivik AS, Aachmann FL, Sal LS, Kim HY, Del Conte R, del Conte R, Gladyshev VN, Dikiy A. 1H, 15N and 13C NMR assignments of mouse methionine sulfoxide reductase B2. Biomol NMR Assign. 2008 Dec; 2(2):199-201. PMID: 19636904; PMCID: PMC3068867.
  211. Hirosawa-Takamori M, Ossipov D, Novoselov SV, Turanov AA, Zhang Y, Gladyshev VN, Krol A, Vorbrüggen G, Jäckle H. A novel stem loop control element-dependent UGA read-through system without translational selenocysteine incorporation in Drosophila. FASEB J. 2009 Jan; 23(1):107-13. PMID: 18772345; PMCID: PMC2626620.
  212. Lee BC, Le DT, Gladyshev VN. Mammals reduce methionine-S-sulfoxide with MsrA and are unable to reduce methionine-R-sulfoxide, and this function can be restored with a yeast reductase. J Biol Chem. 2008 Oct 17; 283(42):28361-9. PMID: 18697736; PMCID: PMC2568918.
  213. Fomenko DE, Marino SM, Gladyshev VN. Functional diversity of cysteine residues in proteins and unique features of catalytic redox-active cysteines in thiol oxidoreductases. Mol Cells. 2008 Sep 30; 26(3):228-35. PMID: 18648218; PMCID: PMC2706539.
  214. Sengupta A, Carlson BA, Weaver JA, Novoselov SV, Fomenko DE, Gladyshev VN, Hatfield DL. A functional link between housekeeping selenoproteins and phase II enzymes. Biochem J. 2008 Jul 01; 413(1):151-61. PMID: 18373496.
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  215. Le DT, Liang X, Fomenko DE, Raza AS, Chong CK, Carlson BA, Hatfield DL, Gladyshev VN. Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized forms. Biochemistry. 2008 Jun 24; 47(25):6685-94. PMID: 18505275.
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  216. Zhang Y, Gladyshev VN. Trends in selenium utilization in marine microbial world revealed through the analysis of the global ocean sampling (GOS) project. PLoS Genet. 2008 Jun 13; 4(6):e1000095. PMID: 18551170; PMCID: PMC2398784.
  217. Zhang Y, Turanov AA, Hatfield DL, Gladyshev VN. In silico identification of genes involved in selenium metabolism: evidence for a third selenium utilization trait. BMC Genomics. 2008 May 29; 9:251. PMID: 18510720; PMCID: PMC2432076.
  218. Shrimali RK, Irons RD, Carlson BA, Sano Y, Gladyshev VN, Park JM, Hatfield DL. Selenoproteins mediate T cell immunity through an antioxidant mechanism. J Biol Chem. 2008 Jul 18; 283(29):20181-5. PMID: 18487203.
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  219. Bonilla M, Denicola A, Novoselov SV, Turanov AA, Protasio A, Izmendi D, Gladyshev VN, Salinas G. Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione. J Biol Chem. 2008 Jun 27; 283(26):17898-907. PMID: 18408002; PMCID: PMC2440607.
  220. Zhang Y, Gladyshev VN. Molybdoproteomes and evolution of molybdenum utilization. J Mol Biol. 2008 Jun 13; 379(4):881-99. PMID: 18485362.
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  221. Lobanov AV, Hatfield DL, Gladyshev VN. Reduced reliance on the trace element selenium during evolution of mammals. Genome Biol. 2008; 9(3):R62. PMID: 18377657; PMCID: PMC2397514.
  222. Castellano S, Gladyshev VN, Guigó R, Berry MJ. SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements. Nucleic Acids Res. 2008 Jan; 36(Database issue):D332-8. PMID: 18174224; PMCID: PMC2238826.
  223. Ridge PG, Zhang Y, Gladyshev VN. Comparative genomic analyses of copper transporters and cuproproteomes reveal evolutionary dynamics of copper utilization and its link to oxygen. PLoS One. 2008 Jan 02; 3(1):e1378. PMID: 18167539; PMCID: PMC2147054.
  224. Lobanov AV, Hatfield DL, Gladyshev VN. Selenoproteinless animals: selenophosphate synthetase SPS1 functions in a pathway unrelated to selenocysteine biosynthesis. Protein Sci. 2008 Jan; 17(1):176-82. PMID: 18156471; PMCID: PMC2144598.
  225. Ganichkin OM, Xu XM, Carlson BA, Mix H, Hatfield DL, Gladyshev VN, Wahl MC. Structure and catalytic mechanism of eukaryotic selenocysteine synthase. J Biol Chem. 2008 Feb 29; 283(9):5849-65. PMID: 18093968.
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  226. Xu XM, Carlson BA, Zhang Y, Mix H, Kryukov GV, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL. New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea. Biol Trace Elem Res. 2007 Dec; 119(3):234-41. PMID: 17916946.
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  227. Zhang Y, Zhou Y, Schweizer U, Savaskan NE, Hua D, Kipnis J, Hatfield DL, Gladyshev VN. Comparative analysis of selenocysteine machinery and selenoproteome gene expression in mouse brain identifies neurons as key functional sites of selenium in mammals. J Biol Chem. 2008 Jan 25; 283(4):2427-38. PMID: 18032379.
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  228. Sengupta A, Carlson BA, Hoffmann VJ, Gladyshev VN, Hatfield DL. Loss of housekeeping selenoprotein expression in mouse liver modulates lipoprotein metabolism. Biochem Biophys Res Commun. 2008 Jan 18; 365(3):446-52. PMID: 17996733.
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  229. Kim HY, Gladyshev VN. Methionine sulfoxide reductases: selenoprotein forms and roles in antioxidant protein repair in mammals. Biochem J. 2007 Nov 01; 407(3):321-9. PMID: 17922679.
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  230. Yoo MH, Xu XM, Carlson BA, Patterson AD, Gladyshev VN, Hatfield DL. Targeting thioredoxin reductase 1 reduction in cancer cells inhibits self-sufficient growth and DNA replication. PLoS One. 2007 Oct 31; 2(10):e1112. PMID: 17971875; PMCID: PMC2040202.
  231. Merchant SS, Prochnik SE, Vallon O, Harris EH, Karpowicz SJ, Witman GB, Terry A, Salamov A, Fritz-Laylin LK, Maréchal-Drouard L, Marshall WF, Qu LH, Nelson DR, Sanderfoot AA, Spalding MH, Kapitonov VV, Ren Q, Ferris P, Lindquist E, Shapiro H, Lucas SM, Grimwood J, Schmutz J, Cardol P, Cerutti H, Chanfreau G, Chen CL, Cognat V, Croft MT, Dent R, Dutcher S, Fernández E, Fukuzawa H, González-Ballester D, González-Halphen D, Hallmann A, Hanikenne M, Hippler M, Inwood W, Jabbari K, Kalanon M, Kuras R, Lefebvre PA, Lemaire SD, Lobanov AV, Lohr M, Manuell A, Meier I, Mets L, Mittag M, Mittelmeier T, Moroney JV, Moseley J, Napoli C, Nedelcu AM, Niyogi K, Novoselov SV, Paulsen IT, Pazour G, Purton S, Ral JP, Riaño-Pachón DM, Riekhof W, Rymarquis L, Schroda M, Stern D, Umen J, Willows R, Wilson N, Zimmer SL, Allmer J, Balk J, Bisova K, Chen CJ, Elias M, Gendler K, Hauser C, Lamb MR, Ledford H, Long JC, Minagawa J, Page MD, Pan J, Pootakham W, Roje S, Rose A, Stahlberg E, Terauchi AM, Yang P, Ball S, Bowler C, Dieckmann CL, Gladyshev VN, Green P, Jorgensen R, Mayfield S, Mueller-Roeber B, Rajamani S, Sayre RT, Brokstein P, Dubchak I, Goodstein D, Hornick L, Huang YW, Jhaveri J, Luo Y, Martínez D, Ngau WC, Otillar B, Poliakov A, Porter A, Szajkowski L, Werner G, Zhou K, Grigoriev IV, Rokhsar DS, Grossman AR. The Chlamydomonas genome reveals the evolution of key animal and plant functions. Science. 2007 Oct 12; 318(5848):245-50. PMID: 17932292; PMCID: PMC2875087.
  232. Aachmann FL, Fomenko DE, Soragni A, Gladyshev VN, Dikiy A. Solution structure of selenoprotein W and NMR analysis of its interaction with 14-3-3 proteins. J Biol Chem. 2007 Dec 21; 282(51):37036-44. PMID: 17928294.
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  233. Carlson BA, Moustafa ME, Sengupta A, Schweizer U, Shrimali R, Rao M, Zhong N, Wang S, Feigenbaum L, Lee BJ, Gladyshev VN, Hatfield DL. Selective restoration of the selenoprotein population in a mouse hepatocyte selenoproteinless background with different mutant selenocysteine tRNAs lacking Um34. J Biol Chem. 2007 Nov 09; 282(45):32591-602. PMID: 17848557.
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  234. Shchedrina VA, Novoselov SV, Malinouski MY, Gladyshev VN. Identification and characterization of a selenoprotein family containing a diselenide bond in a redox motif. Proc Natl Acad Sci U S A. 2007 Aug 28; 104(35):13919-24. PMID: 17715293; PMCID: PMC1955791.
  235. Sal LS, Aachmann FL, Kim HY, Gladyshev VN, Dikiy A. NMR assignments of 1H, 13C and 15N spectra of methionine sulfoxide reductase B1 from Mus musculus. Biomol NMR Assign. 2007 Jul; 1(1):131-3. PMID: 19636847.
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  236. Zhang Y, Gladyshev VN. High content of proteins containing 21st and 22nd amino acids, selenocysteine and pyrrolysine, in a symbiotic deltaproteobacterium of gutless worm Olavius algarvensis. Nucleic Acids Res. 2007; 35(15):4952-63. PMID: 17626042; PMCID: PMC1976440.
  237. Dikiy A, Novoselov SV, Fomenko DE, Sengupta A, Carlson BA, Cerny RL, Ginalski K, Grishin NV, Hatfield DL, Gladyshev VN. SelT, SelW, SelH, and Rdx12: genomics and molecular insights into the functions of selenoproteins of a novel thioredoxin-like family. Biochemistry. 2007 Jun 12; 46(23):6871-82. PMID: 17503775.
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  238. Su D, Berndt C, Fomenko DE, Holmgren A, Gladyshev VN. A conserved cis-proline precludes metal binding by the active site thiolates in members of the thioredoxin family of proteins. Biochemistry. 2007 Jun 12; 46(23):6903-10. PMID: 17503777.
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  239. Xu XM, Carlson BA, Irons R, Mix H, Zhong N, Gladyshev VN, Hatfield DL. Selenophosphate synthetase 2 is essential for selenoprotein biosynthesis. Biochem J. 2007 May 15; 404(1):115-20. PMID: 17346238; PMCID: PMC1868833.
  240. Novoselov SV, Lobanov AV, Hua D, Kasaikina MV, Hatfield DL, Gladyshev VN. A highly efficient form of the selenocysteine insertion sequence element in protozoan parasites and its use in mammalian cells. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):7857-62. PMID: 17470795; PMCID: PMC1876537.
  241. Yoo MH, Xu XM, Turanov AA, Carlson BA, Gladyshev VN, Hatfield DL. A new strategy for assessing selenoprotein function: siRNA knockdown/knock-in targeting the 3'-UTR. RNA. 2007 Jun; 13(6):921-9. PMID: 17468436; PMCID: PMC1869036.
  242. Koc A, Gladyshev VN. Methionine sulfoxide reduction and the aging process. Ann N Y Acad Sci. 2007 Apr; 1100:383-6. PMID: 17460202.
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  243. Novoselov SV, Kryukov GV, Xu XM, Carlson BA, Hatfield DL, Gladyshev VN. Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. J Biol Chem. 2007 Apr 20; 282(16):11960-8. PMID: 17337453.
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  244. Fomenko DE, Xing W, Adair BM, Thomas DJ, Gladyshev VN. High-throughput identification of catalytic redox-active cysteine residues. Science. 2007 Jan 19; 315(5810):387-9. PMID: 17234949.
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  245. Lobanov AV, Fomenko DE, Zhang Y, Sengupta A, Hatfield DL, Gladyshev VN. Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial life. Genome Biol. 2007; 8(9):R198. PMID: 17880704; PMCID: PMC2375036.
  246. Labunskyy VM, Hatfield DL, Gladyshev VN. The Sep15 protein family: roles in disulfide bond formation and quality control in the endoplasmic reticulum. IUBMB Life. 2007 Jan; 59(1):1-5. PMID: 17365173.
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  247. Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL. Biosynthesis of selenocysteine on its tRNA in eukaryotes. PLoS Biol. 2007 Jan; 5(1):e4. PMID: 17194211; PMCID: PMC1717018.
  248. Mix H, Lobanov AV, Gladyshev VN. SECIS elements in the coding regions of selenoprotein transcripts are functional in higher eukaryotes. Nucleic Acids Res. 2007; 35(2):414-23. PMID: 17169995; PMCID: PMC1802603.
  249. Shrimali RK, Weaver JA, Miller GF, Starost MF, Carlson BA, Novoselov SV, Kumaraswamy E, Gladyshev VN, Hatfield DL. Selenoprotein expression is essential in endothelial cell development and cardiac muscle function. Neuromuscul Disord. 2007 Feb; 17(2):135-42. PMID: 17142041; PMCID: PMC1894657.
  250. Kim HY, Fomenko DE, Yoon YE, Gladyshev VN. Catalytic advantages provided by selenocysteine in methionine-S-sulfoxide reductases. Biochemistry. 2006 Nov 21; 45(46):13697-704. PMID: 17105189; PMCID: PMC2519125.
  251. Fernando MR, Lechner JM, Löfgren S, Gladyshev VN, Lou MF. Mitochondrial thioltransferase (glutaredoxin 2) has GSH-dependent and thioredoxin reductase-dependent peroxidase activities in vitro and in lens epithelial cells. FASEB J. 2006 Dec; 20(14):2645-7. PMID: 17065220.
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  252. Zhang Y, Romero H, Salinas G, Gladyshev VN. Dynamic evolution of selenocysteine utilization in bacteria: a balance between selenoprotein loss and evolution of selenocysteine from redox active cysteine residues. Genome Biol. 2006; 7(10):R94. PMID: 17054778; PMCID: PMC1794560.
  253. Lobanov AV, Gromer S, Salinas G, Gladyshev VN. Selenium metabolism in Trypanosoma: characterization of selenoproteomes and identification of a Kinetoplastida-specific selenoprotein. Nucleic Acids Res. 2006; 34(14):4012-24. PMID: 16914442; PMCID: PMC1557815.
  254. Turanov AA, Su D, Gladyshev VN. Characterization of alternative cytosolic forms and cellular targets of mouse mitochondrial thioredoxin reductase. J Biol Chem. 2006 Aug 11; 281(32):22953-63. PMID: 16774913.
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  255. Lobanov AV, Kryukov GV, Hatfield DL, Gladyshev VN. Is there a twenty third amino acid in the genetic code? Trends Genet. 2006 Jul; 22(7):357-60. PMID: 16713651.
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  256. Eckenroth B, Harris K, Turanov AA, Gladyshev VN, Raines RT, Hondal RJ. Semisynthesis and characterization of mammalian thioredoxin reductase. Biochemistry. 2006 Apr 25; 45(16):5158-70. PMID: 16618105; PMCID: PMC2570056.
  257. Yoo MH, Xu XM, Carlson BA, Gladyshev VN, Hatfield DL. Thioredoxin reductase 1 deficiency reverses tumor phenotype and tumorigenicity of lung carcinoma cells. J Biol Chem. 2006 May 12; 281(19):13005-8. PMID: 16565519.
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  258. Kim HY, Gladyshev VN. Alternative first exon splicing regulates subcellular distribution of methionine sulfoxide reductases. BMC Mol Biol. 2006 Mar 16; 7:11. PMID: 16542431; PMCID: PMC1431549.
  259. Novoselov SV, Hua D, Lobanov AV, Gladyshev VN. Identification and characterization of Fep15, a new selenocysteine-containing member of the Sep15 protein family. Biochem J. 2006 Mar 15; 394(Pt 3):575-9. PMID: 16236027; PMCID: PMC1383707.
  260. Lobanov AV, Delgado C, Rahlfs S, Novoselov SV, Kryukov GV, Gromer S, Hatfield DL, Becker K, Gladyshev VN. The Plasmodium selenoproteome. Nucleic Acids Res. 2006; 34(2):496-505. PMID: 16428245; PMCID: PMC1342035.
  261. Hatfield DL, Carlson BA, Xu XM, Mix H, Gladyshev VN. Selenocysteine incorporation machinery and the role of selenoproteins in development and health. Prog Nucleic Acid Res Mol Biol. 2006; 81:97-142. PMID: 16891170.
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  262. Novoselov SV, Calvisi DF, Labunskyy VM, Factor VM, Carlson BA, Fomenko DE, Moustafa ME, Hatfield DL, Gladyshev VN. Selenoprotein deficiency and high levels of selenium compounds can effectively inhibit hepatocarcinogenesis in transgenic mice. Oncogene. 2005 Dec 01; 24(54):8003-11. PMID: 16170372.
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  263. Ferguson AD, Labunskyy VM, Fomenko DE, Araç D, Chelliah Y, Amezcua CA, Rizo J, Gladyshev VN, Deisenhofer J. NMR structures of the selenoproteins Sep15 and SelM reveal redox activity of a new thioredoxin-like family. J Biol Chem. 2006 Feb 10; 281(6):3536-43. PMID: 16319061.
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  264. Kim HY, Gladyshev VN. Different catalytic mechanisms in mammalian selenocysteine- and cysteine-containing methionine-R-sulfoxide reductases. PLoS Biol. 2005 Dec; 3(12):e375. PMID: 16262444; PMCID: PMC1278935.
  265. Sun QA, Su D, Novoselov SV, Carlson BA, Hatfield DL, Gladyshev VN. Reaction mechanism and regulation of mammalian thioredoxin/glutathione reductase. Biochemistry. 2005 Nov 08; 44(44):14528-37. PMID: 16262253.
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  266. Castellano S, Lobanov AV, Chapple C, Novoselov SV, Albrecht M, Hua D, Lescure A, Lengauer T, Krol A, Gladyshev VN, Guigó R. Diversity and functional plasticity of eukaryotic selenoproteins: identification and characterization of the SelJ family. Proc Natl Acad Sci U S A. 2005 Nov 08; 102(45):16188-93. PMID: 16260744; PMCID: PMC1283428.
  267. Xu XM, Mix H, Carlson BA, Grabowski PJ, Gladyshev VN, Berry MJ, Hatfield DL. Evidence for direct roles of two additional factors, SECp43 and soluble liver antigen, in the selenoprotein synthesis machinery. J Biol Chem. 2005 Dec 16; 280(50):41568-75. PMID: 16230358.
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  268. Biterova EI, Turanov AA, Gladyshev VN, Barycki JJ. Crystal structures of oxidized and reduced mitochondrial thioredoxin reductase provide molecular details of the reaction mechanism. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15018-23. PMID: 16217027; PMCID: PMC1257698.
  269. Labunskyy VM, Ferguson AD, Fomenko DE, Chelliah Y, Hatfield DL, Gladyshev VN. A novel cysteine-rich domain of Sep15 mediates the interaction with UDP-glucose:glycoprotein glucosyltransferase. J Biol Chem. 2005 Nov 11; 280(45):37839-45. PMID: 16129668.
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  270. Romero H, Zhang Y, Gladyshev VN, Salinas G. Evolution of selenium utilization traits. Genome Biol. 2005; 6(8):R66. PMID: 16086848; PMCID: PMC1273633.
  271. Kim HY, Gladyshev VN. Role of structural and functional elements of mouse methionine-S-sulfoxide reductase in its subcellular distribution. Biochemistry. 2005 Jun 07; 44(22):8059-67. PMID: 15924425.
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  272. Su D, Novoselov SV, Sun QA, Moustafa ME, Zhou Y, Oko R, Hatfield DL, Gladyshev VN. Mammalian selenoprotein thioredoxin-glutathione reductase. Roles in disulfide bond formation and sperm maturation. J Biol Chem. 2005 Jul 15; 280(28):26491-8. PMID: 15901730.
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  273. Su D, Li Y, Gladyshev VN. Selenocysteine insertion directed by the 3'-UTR SECIS element in Escherichia coli. Nucleic Acids Res. 2005; 33(8):2486-92. PMID: 15863725; PMCID: PMC1087901.
  274. Taskov K, Chapple C, Kryukov GV, Castellano S, Lobanov AV, Korotkov KV, Guigó R, Gladyshev VN. Nematode selenoproteome: the use of the selenocysteine insertion system to decode one codon in an animal genome? Nucleic Acids Res. 2005; 33(7):2227-38. PMID: 15843685; PMCID: PMC1083425.
  275. Shrimali RK, Lobanov AV, Xu XM, Rao M, Carlson BA, Mahadeo DC, Parent CA, Gladyshev VN, Hatfield DL. Selenocysteine tRNA identification in the model organisms Dictyostelium discoideum and Tetrahymena thermophila. Biochem Biophys Res Commun. 2005 Apr 01; 329(1):147-51. PMID: 15721286.
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  276. Zhang Y, Gladyshev VN. An algorithm for identification of bacterial selenocysteine insertion sequence elements and selenoprotein genes. Bioinformatics. 2005 Jun 01; 21(11):2580-9. PMID: 15797911.
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  277. Zhang Y, Fomenko DE, Gladyshev VN. The microbial selenoproteome of the Sargasso Sea. Genome Biol. 2005; 6(4):R37. PMID: 15833124; PMCID: PMC1088965.
  278. Zhang Y, Baranov PV, Atkins JF, Gladyshev VN. Pyrrolysine and selenocysteine use dissimilar decoding strategies. J Biol Chem. 2005 May 27; 280(21):20740-51. PMID: 15788401.
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  279. Carlson BA, Xu XM, Gladyshev VN, Hatfield DL. Selective rescue of selenoprotein expression in mice lacking a highly specialized methyl group in selenocysteine tRNA. J Biol Chem. 2005 Feb 18; 280(7):5542-8. PMID: 15611090.
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  280. Su D, Gladyshev VN. Alternative splicing involving the thioredoxin reductase module in mammals: a glutaredoxin-containing thioredoxin reductase 1. Biochemistry. 2004 Sep 28; 43(38):12177-88. PMID: 15379556.
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  281. Carlson BA, Xu XM, Kryukov GV, Rao M, Berry MJ, Gladyshev VN, Hatfield DL. Identification and characterization of phosphoseryl-tRNA[Ser]Sec kinase. Proc Natl Acad Sci U S A. 2004 Aug 31; 101(35):12848-53. PMID: 15317934; PMCID: PMC516484.
  282. Kim HY, Gladyshev VN. Characterization of mouse endoplasmic reticulum methionine-R-sulfoxide reductase. Biochem Biophys Res Commun. 2004 Aug 06; 320(4):1277-83. PMID: 15249228.
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  283. Koc A, Gasch AP, Rutherford JC, Kim HY, Gladyshev VN. Methionine sulfoxide reductase regulation of yeast lifespan reveals reactive oxygen species-dependent and -independent components of aging. Proc Natl Acad Sci U S A. 2004 May 25; 101(21):7999-8004. PMID: 15141092; PMCID: PMC419546.
  284. Kryukov GV, Gladyshev VN. The prokaryotic selenoproteome. EMBO Rep. 2004 May; 5(5):538-43. PMID: 15105824; PMCID: PMC1299047.
  285. Castellano S, Novoselov SV, Kryukov GV, Lescure A, Blanco E, Krol A, Gladyshev VN, Guigó R. Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. EMBO Rep. 2004 Jan; 5(1):71-7. PMID: 14710190; PMCID: PMC1298953.
  286. Gladyshev VN, Kryukov GV, Fomenko DE, Hatfield DL. Identification of trace element-containing proteins in genomic databases. Annu Rev Nutr. 2004; 24:579-96. PMID: 15189132.
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  287. Kim HY, Gladyshev VN. Methionine sulfoxide reduction in mammals: characterization of methionine-R-sulfoxide reductases. Mol Biol Cell. 2004 Mar; 15(3):1055-64. PMID: 14699060.
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  288. Carlson BA, Novoselov SV, Kumaraswamy E, Lee BJ, Anver MR, Gladyshev VN, Hatfield DL. Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function. J Biol Chem. 2004 Feb 27; 279(9):8011-7. PMID: 14660662.
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  289. Kwon SY, Badenhorst P, Martin-Romero FJ, Carlson BA, Paterson BM, Gladyshev VN, Lee BJ, Hatfield DL. The Drosophila selenoprotein BthD is required for survival and has a role in salivary gland development. Mol Cell Biol. 2003 Dec; 23(23):8495-504. PMID: 14612395; PMCID: PMC262655.
  290. Fomenko DE, Gladyshev VN. Identity and functions of CxxC-derived motifs. Biochemistry. 2003 Sep 30; 42(38):11214-25. PMID: 14503871.
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  291. Thisse C, Degrave A, Kryukov GV, Gladyshev VN, Obrecht-Pflumio S, Krol A, Thisse B, Lescure A. Spatial and temporal expression patterns of selenoprotein genes during embryogenesis in zebrafish. Gene Expr Patterns. 2003 Aug; 3(4):525-32. PMID: 12915322.
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  292. Rao M, Carlson BA, Novoselov SV, Weeks DP, Gladyshev VN, Hatfield DL. Chlamydomonas reinhardtii selenocysteine tRNA[Ser]Sec. RNA. 2003 Aug; 9(8):923-30. PMID: 12869703; PMCID: PMC1370458.
  293. Fomenko DE, Gladyshev VN. Genomics perspective on disulfide bond formation. Antioxid Redox Signal. 2003 Aug; 5(4):397-402. PMID: 13678527.
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  294. Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigó R, Gladyshev VN. Characterization of mammalian selenoproteomes. Science. 2003 May 30; 300(5624):1439-43. PMID: 12775843.
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  295. Kumaraswamy E, Carlson BA, Morgan F, Miyoshi K, Robinson GW, Su D, Wang S, Southon E, Tessarollo L, Lee BJ, Gladyshev VN, Hennighausen L, Hatfield DL. Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium. Mol Cell Biol. 2003 Mar; 23(5):1477-88. PMID: 12588969; PMCID: PMC151713.
  296. Novoselov SV, Gladyshev VN. Non-animal origin of animal thioredoxin reductases: implications for selenocysteine evolution and evolution of protein function through carboxy-terminal extensions. Protein Sci. 2003 Feb; 12(2):372-8. PMID: 12538901; PMCID: PMC2312427.
  297. Xu XM, Carlson BA, Grimm TA, Kutza J, Berry MJ, Arreola R, Fields KH, Shanmugam I, Jeang KT, Oroszlan S, Combs GF, Marx PA, Gladyshev VN, Clouse KA, Hatfield DL. Rhesus monkey simian immunodeficiency virus infection as a model for assessing the role of selenium in AIDS. J Acquir Immune Defic Syndr. 2002 Dec 15; 31(5):453-63. PMID: 12473832.
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  298. Fomenko DE, Gladyshev VN. CxxS: fold-independent redox motif revealed by genome-wide searches for thiol/disulfide oxidoreductase function. Protein Sci. 2002 Oct; 11(10):2285-96. PMID: 12237451; PMCID: PMC2373698.
  299. Kumar RA, Koc A, Cerny RL, Gladyshev VN. Reaction mechanism, evolutionary analysis, and role of zinc in Drosophila methionine-R-sulfoxide reductase. J Biol Chem. 2002 Oct 04; 277(40):37527-35. PMID: 12145281.
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  300. Novoselov SV, Rao M, Onoshko NV, Zhi H, Kryukov GV, Xiang Y, Weeks DP, Hatfield DL, Gladyshev VN. Selenoproteins and selenocysteine insertion system in the model plant cell system, Chlamydomonas reinhardtii. EMBO J. 2002 Jul 15; 21(14):3681-93. PMID: 12110581; PMCID: PMC126117.
  301. Hatfield DL, Gladyshev VN. How selenium has altered our understanding of the genetic code. Mol Cell Biol. 2002 Jun; 22(11):3565-76. PMID: 11997494; PMCID: PMC133838.
  302. Kryukov GV, Kumar RA, Koc A, Sun Z, Gladyshev VN. Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4245-50. PMID: 11929995; PMCID: PMC123633.
  303. Korotkov KV, Novoselov SV, Hatfield DL, Gladyshev VN. Mammalian selenoprotein in which selenocysteine (Sec) incorporation is supported by a new form of Sec insertion sequence element. Mol Cell Biol. 2002 Mar; 22(5):1402-11. PMID: 11839807; PMCID: PMC134693.
  304. Gladyshev VN. Thioredoxin and peptide methionine sulfoxide reductase: convergence of similar structure and function in distinct structural folds. Proteins. 2002 Feb 01; 46(2):149-52. PMID: 11807942.
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  305. Gladyshev VN. Comparison of selenium-containing molybdoenzymes. Met Ions Biol Syst. 2002; 39:655-72. PMID: 11913139.
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  306. Kumaraswamy E, Korotkov KV, Diamond AM, Gladyshev VN, Hatfield DL. Genetic and functional analysis of mammalian Sep15 selenoprotein. Methods Enzymol. 2002; 347:187-97. PMID: 11898406.
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  307. Kryukov GV, Gladyshev VN. Mammalian selenoprotein gene signature: identification and functional analysis of selenoprotein genes using bioinformatics methods. Methods Enzymol. 2002; 347:84-100. PMID: 11898441.
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  308. Sun QA, Gladyshev VN. Redox regulation of cell signaling by thioredoxin reductases. Methods Enzymol. 2002; 347:451-61. PMID: 11898437.
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  309. Gladyshev VN, Liu A, Novoselov SV, Krysan K, Sun QA, Kryukov VM, Kryukov GV, Lou MF. Identification and characterization of a new mammalian glutaredoxin (thioltransferase), Grx2. J Biol Chem. 2001 Aug 10; 276(32):30374-80. PMID: 11397793.
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  310. Martin-Romero FJ, Kryukov GV, Lobanov AV, Carlson BA, Lee BJ, Gladyshev VN, Hatfield DL. Selenium metabolism in Drosophila: selenoproteins, selenoprotein mRNA expression, fertility, and mortality. J Biol Chem. 2001 Aug 10; 276(32):29798-804. PMID: 11389138.
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  311. Moustafa ME, Carlson BA, El-Saadani MA, Kryukov GV, Sun QA, Harney JW, Hill KE, Combs GF, Feigenbaum L, Mansur DB, Burk RF, Berry MJ, Diamond AM, Lee BJ, Gladyshev VN, Hatfield DL. Selective inhibition of selenocysteine tRNA maturation and selenoprotein synthesis in transgenic mice expressing isopentenyladenosine-deficient selenocysteine tRNA. Mol Cell Biol. 2001 Jun; 21(11):3840-52. PMID: 11340175; PMCID: PMC87048.
  312. Gladyshev VN, Hatfield DL. Analysis of selenocysteine-containing proteins. Curr Protoc Protein Sci. 2001 May; Chapter 3:Unit 3.8. PMID: 18429173.
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  313. Sun QA, Kirnarsky L, Sherman S, Gladyshev VN. Selenoprotein oxidoreductase with specificity for thioredoxin and glutathione systems. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3673-8. PMID: 11259642; PMCID: PMC31110.
  314. Hu YJ, Korotkov KV, Mehta R, Hatfield DL, Rotimi CN, Luke A, Prewitt TE, Cooper RS, Stock W, Vokes EE, Dolan ME, Gladyshev VN, Diamond AM. Distribution and functional consequences of nucleotide polymorphisms in the 3'-untranslated region of the human Sep15 gene. Cancer Res. 2001 Mar 01; 61(5):2307-10. PMID: 11280803.
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  315. Korotkov KV, Kumaraswamy E, Zhou Y, Hatfield DL, Gladyshev VN. Association between the 15-kDa selenoprotein and UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic reticulum of mammalian cells. J Biol Chem. 2001 May 04; 276(18):15330-6. PMID: 11278576.
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  316. Gladyshev VN, Kryukov GV. Evolution of selenocysteine-containing proteins: significance of identification and functional characterization of selenoproteins. Biofactors. 2001; 14(1-4):87-92. PMID: 11568444.
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  317. Kryukov GV, Gladyshev VN. Selenium metabolism in zebrafish: multiplicity of selenoprotein genes and expression of a protein containing 17 selenocysteine residues. Genes Cells. 2000 Dec; 5(12):1049-60. PMID: 11168591.
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  318. Kumaraswamy E, Malykh A, Korotkov KV, Kozyavkin S, Hu Y, Kwon SY, Moustafa ME, Carlson BA, Berry MJ, Lee BJ, Hatfield DL, Diamond AM, Gladyshev VN. Structure-expression relationships of the 15-kDa selenoprotein gene. Possible role of the protein in cancer etiology. J Biol Chem. 2000 Nov 10; 275(45):35540-7. PMID: 10945981.
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  319. Sun QA, Zappacosta F, Factor VM, Wirth PJ, Hatfield DL, Gladyshev VN. Heterogeneity within animal thioredoxin reductases. Evidence for alternative first exon splicing. J Biol Chem. 2001 Feb 02; 276(5):3106-14. PMID: 11060283.
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  320. Mansur DB, Hao H, Gladyshev VN, Korotkov KV, Hu Y, Moustafa ME, El-Saadani MA, Carlson BA, Hatfield DL, Diamond AM. Multiple levels of regulation of selenoprotein biosynthesis revealed from the analysis of human glioma cell lines. Biochem Pharmacol. 2000 Aug 15; 60(4):489-97. PMID: 10874123.
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  321. Kryukov GV, Kryukov VM, Gladyshev VN. New mammalian selenocysteine-containing proteins identified with an algorithm that searches for selenocysteine insertion sequence elements. J Biol Chem. 1999 Nov 26; 274(48):33888-97. PMID: 10567350.
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  322. Sun QA, Wu Y, Zappacosta F, Jeang KT, Lee BJ, Hatfield DL, Gladyshev VN. Redox regulation of cell signaling by selenocysteine in mammalian thioredoxin reductases. J Biol Chem. 1999 Aug 27; 274(35):24522-30. PMID: 10455115.
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  323. Gladyshev VN, Krause M, Xu XM, Korotkov KV, Kryukov GV, Sun QA, Lee BJ, Wootton JC, Hatfield DL. Selenocysteine-containing thioredoxin reductase in C. elegans. Biochem Biophys Res Commun. 1999 Jun 07; 259(2):244-9. PMID: 10362494.
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  324. Gladyshev VN, Hatfield DL. Selenocysteine-containing proteins in mammals. J Biomed Sci. 1999 May-Jun; 6(3):151-60. PMID: 10343164.
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  325. Gladyshev VN, Stadtman TC, Hatfield DL, Jeang KT. Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase. Proc Natl Acad Sci U S A. 1999 Feb 02; 96(3):835-9. PMID: 9927654; PMCID: PMC15311.
  326. Gladyshev VN, Factor VM, Housseau F, Hatfield DL. Contrasting patterns of regulation of the antioxidant selenoproteins, thioredoxin reductase, and glutathione peroxidase, in cancer cells. Biochem Biophys Res Commun. 1998 Oct 20; 251(2):488-93. PMID: 9792801.
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  327. Gladyshev VN, Jeang KT, Wootton JC, Hatfield DL. A new human selenium-containing protein. Purification, characterization, and cDNA sequence. J Biol Chem. 1998 Apr 10; 273(15):8910-5. PMID: 9535873.
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  328. Khangulov SV, Gladyshev VN, Dismukes GC, Stadtman TC. Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer. Biochemistry. 1998 Mar 10; 37(10):3518-28. PMID: 9521673.
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  329. Klyachko NL, Vakula SV, Gladyshev VN, Tishkov VI, Levashov AV. Formate dehydrogenase in a reversed micelle system: regulation of catalytic activity and oligomeric composition of the enzyme. Biochemistry (Mosc). 1997 Dec; 62(12):1439-43. PMID: 9481877.
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  330. Boyington JC, Gladyshev VN, Khangulov SV, Stadtman TC, Sun PD. Crystal structure of formate dehydrogenase H: catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster. Science. 1997 Feb 28; 275(5304):1305-8. PMID: 9036855.
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  331. Gladyshev VN, Jeang KT, Stadtman TC. Selenocysteine, identified as the penultimate C-terminal residue in human T-cell thioredoxin reductase, corresponds to TGA in the human placental gene. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):6146-51. PMID: 8650234; PMCID: PMC39204.
  332. Gladyshev VN, Boyington JC, Khangulov SV, Grahame DA, Stadtman TC, Sun PD. Characterization of crystalline formate dehydrogenase H from Escherichia coli. Stabilization, EPR spectroscopy, and preliminary crystallographic analysis. J Biol Chem. 1996 Apr 05; 271(14):8095-100. PMID: 8626495.
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  333. Gladyshev VN, Khangulov SV, Stadtman TC. Properties of the selenium- and molybdenum-containing nicotinic acid hydroxylase from Clostridium barkeri. Biochemistry. 1996 Jan 09; 35(1):212-23. PMID: 8555176.
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  334. Gladyshev VN, Lecchi P. Identification of molybdopterins in molybdenum- and selenium-containing enzymes. Biofactors. 1995-1996; 5(2):93-7. PMID: 8722123.
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  335. Tamura T, Gladyshev V, Liu SY, Stadtman TC. The mutual sparing effects of selenium and vitamin E in animal nutrition may be further explained by the discovery that mammalian thioredoxin reductase is a selenoenzyme. Biofactors. 1995-1996; 5(2):99-102. PMID: 8722124.
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  336. Gladyshev VN, Khangulov SV, Axley MJ, Stadtman TC. Coordination of selenium to molybdenum in formate dehydrogenase H from Escherichia coli. Proc Natl Acad Sci U S A. 1994 Aug 02; 91(16):7708-11. PMID: 8052647; PMCID: PMC44471.
  337. Gladyshev VN, Khangulov SV, Stadtman TC. Nicotinic acid hydroxylase from Clostridium barkeri: electron paramagnetic resonance studies show that selenium is coordinated with molybdenum in the catalytically active selenium-dependent enzyme. Proc Natl Acad Sci U S A. 1994 Jan 04; 91(1):232-6. PMID: 8278371; PMCID: PMC42921.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.