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John Higgins, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL158102 (SO, PETER T.) May 1, 2021 - Apr 30, 2025
    Single-cell measurement of cyclic stress on sickle blood cells by imaging-microfluidics
    Role: Co-Principal Investigator
  2. OT2HL152639 (WILLIAMS, DAVID A) Sep 20, 2019 - Apr 17, 2020
    Boston Consortium to Cure SCD - Williams/John Higgins
    Role: Co-Principal Investigator
  3. U01HL114476 (KARNIADAKIS, GEORGE) Sep 1, 2013 - May 31, 2019
    Multiscale Modeling of Sickle Cell Anemia: Methods and Validation
    Role: Co-Principal Investigator
  4. DP2DK098087 (HIGGINS, JOHN MATTHEW) Sep 28, 2012 - Jun 30, 2017
    Systems Biology of In Vivo Human Blood Cell Populations
    Role: Principal Investigator
  5. K08DK083242 (HIGGINS, JOHN MATTHEW) Aug 20, 2008 - Mar 31, 2014
    Quantitative Analysis of Blood Flow in Sickle Cell Disease
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Foy BH, Sundt T, Carlson JCT, Aguirre AD, Higgins JM. White Blood Cell and Platelet Dynamics Define Human Inflammatory Recovery. medRxiv. 2021 Jun 23. PMID: 34189534.
  2. Mukerji SS, Das S, Alabsi H, Brenner LN, Jain A, Magdamo C, Collens SI, Ye E, Keller K, Boutros CL, Leone MJ, Newhouse A, Foy B, Li MD, Lang M, Anahtar MN, Shao YP, Ge W, Sun H, Triant VA, Kalpathy-Cramer J, Higgins J, Rosand J, Robbins GK, Westover MB. Prolonged Intubation in Patients With Prior Cerebrovascular Disease and COVID-19. Front Neurol. 2021; 12:642912. PMID: 33897598.
    Citations: 1     
  3. Demers M, Sturtevant S, Guertin KR, Gupta D, Desai K, Vieira BF, Li W, Hicks A, Ismail A, Gonçalves BP, Di Caprio G, Schonbrun E, Hansen S, Musayev FN, Safo MK, Wood DK, Higgins JM, Light DR. MetAP2 inhibition modifies hemoglobin S to delay polymerization and improves blood flow in sickle cell disease. Blood Adv. 2021 03 09; 5(5):1388-1402. PMID: 33661300.
    Citations:    Fields:    Translation:HumansAnimalsCells
  4. Powe CE, James K, Higgins JM. Response to Letter to the Editor From Marie Monlun: "Longitudinal Changes in the Relationship Between Hemoglobin A1c and Glucose Tolerance Across Pregnancy and Postpartum". J Clin Endocrinol Metab. 2021 01 01; 106(1):e401-e402. PMID: 32589732.
    Citations:    Fields:    Translation:Humans
  5. Foy BH, Carlson JCT, Reinertsen E, Padros I Valls R, Pallares Lopez R, Palanques-Tost E, Mow C, Westover MB, Aguirre AD, Higgins JM. Association of Red Blood Cell Distribution Width With Mortality Risk in Hospitalized Adults With SARS-CoV-2 Infection. JAMA Netw Open. 2020 09 01; 3(9):e2022058. PMID: 32965501.
    Citations: 39     Fields:    Translation:HumansCellsPHPublic Health
  6. Edelson PK, James KE, Leong A, Arenas J, Cayford M, Callahan MJ, Bernstein SN, Tangren JS, Hivert MF, Higgins JM, Nathan DM, Powe CE. Longitudinal Changes in the Relationship Between Hemoglobin A1c and Glucose Tolerance Across Pregnancy and Postpartum. J Clin Endocrinol Metab. 2020 05 01; 105(5). PMID: 32010954.
    Citations: 3     Fields:    Translation:HumansCells
  7. Cremer S, Schloss MJ, Vinegoni C, Foy BH, Zhang S, Rohde D, Hulsmans M, Fumene Feruglio P, Schmidt S, Wojtkiewicz G, Higgins JM, Weissleder R, Swirski FK, Nahrendorf M. Diminished Reactive Hematopoiesis and Cardiac Inflammation in a Mouse Model of Recurrent Myocardial Infarction. J Am Coll Cardiol. 2020 03 03; 75(8):901-915. PMID: 32130926.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  8. Malka R, Brugnara C, Cialic R, Higgins JM. Non-Parametric Combined Reference Regions and Prediction of Clinical Risk. Clin Chem. 2020 02 01; 66(2):363-372. PMID: 32040586.
    Citations:    Fields:    Translation:Humans
  9. Foy BH, Gonçalves BP, Higgins JM. Unraveling Disease Pathophysiology with Mathematical Modeling. Annu Rev Pathol. 2020 01 24; 15:371-394. PMID: 31977295.
    Citations: 3     Fields:    Translation:HumansAnimals
  10. Hansen S, Wood DK, Higgins JM. 5-(Hydroxymethyl)furfural restores low-oxygen rheology of sickle trait blood in vitro. Br J Haematol. 2020 03; 188(6):985-993. PMID: 31889311.
    Citations: 2     Fields:    Translation:Humans
  11. Foy BH, Li A, McClung JP, Ranganath R, Higgins JM. Data-driven physiologic thresholds for iron deficiency associated with hematologic decline. Am J Hematol. 2020 03; 95(3):302-309. PMID: 31849101.
    Citations: 4     Fields:    Translation:HumansCellsCTClinical Trials
  12. Chaudhury A, Miller GD, Eichner D, Higgins JM. Single-cell modeling of routine clinical blood tests reveals transient dynamics of human response to blood loss. Elife. 2019 12 17; 8. PMID: 31845889.
    Citations: 5     Fields:    Translation:HumansCells
  13. Di Caprio G, Schonbrun E, Gonçalves BP, Valdez JM, Wood DK, Higgins JM. High-throughput assessment of hemoglobin polymer in single red blood cells from sickle cell patients under controlled oxygen tension. Proc Natl Acad Sci U S A. 2019 12 10; 116(50):25236-25242. PMID: 31767751.
    Citations: 5     Fields:    Translation:HumansCells
  14. Valdez JM, Datta YH, Higgins JM, Wood DK. A microfluidic platform for simultaneous quantification of oxygen-dependent viscosity and shear thinning in sickle cell blood. APL Bioeng. 2019 Dec; 3(4):046102. PMID: 31803859.
    Citations: 4     
  15. Larkin ME, Nathan DM, Bebu I, Krause-Steinrauf H, Herman WH, Higgins JM, Tiktin M, Cohen RM, Lund C, Bergenstal RM, Johnson ML, Arends V. Rationale and Design for a GRADE Substudy of Continuous Glucose Monitoring. Diabetes Technol Ther. 2019 12; 21(12):682-690. PMID: 31393176.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  16. Cohen RM, Franco RS, Smith EP, Higgins JM. When HbA1c and Blood Glucose Do Not Match: How Much Is Determined by Race, by Genetics, by Differences in Mean Red Blood Cell Age? J Clin Endocrinol Metab. 2019 03 01; 104(3):707-710. PMID: 30445523.
    Citations: 10     Fields:    Translation:HumansCells
  17. Lu X, Chaudhury A, Higgins JM, Wood DK. Oxygen-dependent flow of sickle trait blood as an in vitro therapeutic benchmark for sickle cell disease treatments. Am J Hematol. 2018 10; 93(10):1227-1235. PMID: 30033564.
    Citations: 5     Fields:    Translation:Humans
  18. Chaudhury A, Noiret L, Higgins JM. White blood cell population dynamics for risk stratification of acute coronary syndrome. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):12344-12349. PMID: 29087321.
    Citations: 4     Fields:    Translation:HumansCells
  19. Lu X, Galarneau MM, Higgins JM, Wood DK. A microfluidic platform to study the effects of vascular architecture and oxygen gradients on sickle blood flow. Microcirculation. 2017 07; 24(5). PMID: 28129479.
    Citations: 4     Fields:    Translation:Humans
  20. Noiret L, Slater A, Higgins JM. Determinants of red blood cell alloantibody detection duration: analysis of multiply alloimmunized patients supports peritransfusion factors. Transfusion. 2017 08; 57(8):1930-1937. PMID: 28639314.
    Citations:    Fields:    Translation:HumansCells
  21. Malka R, Nathan DM, Higgins JM. Mechanistic modeling of hemoglobin glycation and red blood cell kinetics enables personalized diabetes monitoring. Sci Transl Med. 2016 10 05; 8(359):359ra130. PMID: 27708063.
    Citations: 25     Fields:    Translation:HumansCells
  22. Hosseini P, Abidi SZ, Du E, Papageorgiou DP, Choi Y, Park Y, Higgins JM, Kato GJ, Suresh S, Dao M, Yaqoob Z, So PT. Cellular normoxic biophysical markers of hydroxyurea treatment in sickle cell disease. Proc Natl Acad Sci U S A. 2016 08 23; 113(34):9527-32. PMID: 27512047.
    Citations: 16     Fields:    Translation:HumansCells
  23. Lu X, Wood DK, Higgins JM. Deoxygenation Reduces Sickle Cell Blood Flow at Arterial Oxygen Tension. Biophys J. 2016 Jun 21; 110(12):2751-2758. PMID: 27332133.
    Citations: 12     Fields:    Translation:Humans
  24. Di Caprio G, Stokes C, Higgins JM, Schonbrun E. Single-cell measurement of red blood cell oxygen affinity. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):9984-9. PMID: 26216973.
    Citations: 12     Fields:    Translation:HumansCells
  25. Huck A, Pozdnyakova O, Brunner A, Higgins JM, Fathi AT, Hasserjian RP. Prior cytopenia predicts worse clinical outcome in acute myeloid leukemia. Leuk Res. 2015 Oct; 39(10):1034-40. PMID: 26220865.
    Citations: 3     Fields:    Translation:Humans
  26. Patel HH, Patel HR, Higgins JM. Modulation of red blood cell population dynamics is a fundamental homeostatic response to disease. Am J Hematol. 2015 May; 90(5):422-8. PMID: 25691355.
    Citations: 32     Fields:    Translation:HumansCells
  27. Higgins JM. Red blood cell population dynamics. Clin Lab Med. 2015 Mar; 35(1):43-57. PMID: 25676371.
    Citations: 15     Fields:    Translation:HumansCells
  28. Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kuo FC, Kluk MJ, Henderson B, Kinnunen L, Koistinen HA, Ladenvall C, Getz G, Correa A, Banahan BF, Gabriel S, Kathiresan S, Stringham HM, McCarthy MI, Boehnke M, Tuomilehto J, Haiman C, Groop L, Atzmon G, Wilson JG, Neuberg D, Altshuler D, Ebert BL. Age-related clonal hematopoiesis associated with adverse outcomes. N Engl J Med. 2014 Dec 25; 371(26):2488-98. PMID: 25426837.
    Citations: 1092     Fields:    Translation:HumansCells
  29. Malka R, Delgado FF, Manalis SR, Higgins JM. In vivo volume and hemoglobin dynamics of human red blood cells. PLoS Comput Biol. 2014 Oct; 10(10):e1003839. PMID: 25299941.
    Citations: 8     Fields:    Translation:HumansCells
  30. Louis DN, Gerber GK, Baron JM, Bry L, Dighe AS, Getz G, Higgins JM, Kuo FC, Lane WJ, Michaelson JS, Le LP, Mermel CH, Gilbertson JR, Golden JA. Computational pathology: an emerging definition. Arch Pathol Lab Med. 2014 Sep; 138(9):1133-8. PMID: 25171694.
    Citations: 21     Fields:    Translation:Humans
  31. Archer NM, Shmukler BE, Andolfo I, Vandorpe DH, Gnanasambandam R, Higgins JM, Rivera A, Fleming MD, Sachs F, Gottlieb PA, Iolascon A, Brugnara C, Alper SL, Nathan DG. Hereditary xerocytosis revisited. Am J Hematol. 2014 Dec; 89(12):1142-6. PMID: 25044010.
    Citations: 19     Fields:    Translation:HumansCells
  32. Golub MS, Hogrefe CE, Malka R, Higgins JM. Developmental plasticity of red blood cell homeostasis. Am J Hematol. 2014 May; 89(5):459-66. PMID: 24415575.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  33. Schonbrun E, Malka R, Di Caprio G, Schaak D, Higgins JM. Quantitative absorption cytometry for measuring red blood cell hemoglobin mass and volume. Cytometry A. 2014 Apr; 85(4):332-8. PMID: 24677669.
    Citations: 14     Fields:    Translation:HumansCells
  34. Baron JM, Dighe AS, Arnaout R, Balis UJ, Black-Schaffer WS, Carter AB, Henricks WH, Higgins JM, Jackson BR, Kim J, Klepeis VE, Le LP, Louis DN, Mandelker D, Mermel CH, Michaelson JS, Nagarajan R, Platt ME, Quinn AM, Rao L, Shirts BH, Gilbertson JR. The 2013 symposium on pathology data integration and clinical decision support and the current state of field. J Pathol Inform. 2014; 5(1):2. PMID: 24672737.
    Citations: 3     
  35. Feijó Delgado F, Cermak N, Hecht VC, Son S, Li Y, Knudsen SM, Olcum S, Higgins JM, Chen J, Grover WH, Manalis SR. Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells. PLoS One. 2013; 8(7):e67590. PMID: 23844039.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  36. Byun H, Hillman TR, Higgins JM, Diez-Silva M, Peng Z, Dao M, Dasari RR, Suresh S, Park Y. Optical measurement of biomechanical properties of individual erythrocytes from a sickle cell patient. Acta Biomater. 2012 Nov; 8(11):4130-8. PMID: 22820310.
    Citations: 33     Fields:    Translation:HumansCells
  37. Kim Y, Higgins JM, Dasari RR, Suresh S, Park Y. Anisotropic light scattering of individual sickle red blood cells. J Biomed Opt. 2012 Apr; 17(4):040501. PMID: 22559667.
    Citations: 6     Fields:    Translation:HumansCells
  38. Wood DK, Soriano A, Mahadevan L, Higgins JM, Bhatia SN. A biophysical indicator of vaso-occlusive risk in sickle cell disease. Sci Transl Med. 2012 Feb 29; 4(123):123ra26. PMID: 22378926.
    Citations: 44     Fields:    Translation:Humans
  39. Leuschner F, Rauch PJ, Ueno T, Gorbatov R, Marinelli B, Lee WW, Dutta P, Wei Y, Robbins C, Iwamoto Y, Sena B, Chudnovskiy A, Panizzi P, Keliher E, Higgins JM, Libby P, Moskowitz MA, Pittet MJ, Swirski FK, Weissleder R, Nahrendorf M. Rapid monocyte kinetics in acute myocardial infarction are sustained by extramedullary monocytopoiesis. J Exp Med. 2012 Jan 16; 209(1):123-37. PMID: 22213805.
    Citations: 206     Fields:    Translation:AnimalsCells
  40. Baron JM, Higgins JM, Dzik WH. A revised timeline for the origin of Plasmodium falciparum as a human pathogen. J Mol Evol. 2011 Dec; 73(5-6):297-304. PMID: 22183792.
    Citations: 6     Fields:    Translation:HumansAnimals
  41. Grover WH, Bryan AK, Diez-Silva M, Suresh S, Higgins JM, Manalis SR. Measuring single-cell density. Proc Natl Acad Sci U S A. 2011 Jul 05; 108(27):10992-6. PMID: 21690360.
    Citations: 74     Fields:    Translation:HumansAnimalsCells
  42. Higgins JM, Mahadevan L. Physiological and pathological population dynamics of circulating human red blood cells. Proc Natl Acad Sci U S A. 2010 Nov 23; 107(47):20587-92. PMID: 21059904.
    Citations: 26     Fields:    Translation:HumansCells
  43. Setoguchi S, Higgins JM, Mogun H, Mootha VK, Avorn J. Propranolol and the risk of hospitalized myopathy: translating chemical genomics findings into population-level hypotheses. Am Heart J. 2010 Mar; 159(3):428-33. PMID: 20211305.
    Citations: 2     Fields:    Translation:Humans
  44. Higgins JM, Eddington DT, Bhatia SN, Mahadevan L. Statistical dynamics of flowing red blood cells by morphological image processing. PLoS Comput Biol. 2009 Feb; 5(2):e1000288. PMID: 19214200.
    Citations: 18     Fields:    Translation:HumansCells
  45. Higgins JM, Sloan SR. Stochastic modeling of human RBC alloimmunization: evidence for a distinct population of immunologic responders. Blood. 2008 Sep 15; 112(6):2546-53. PMID: 18535200.
    Citations: 48     Fields:    Translation:HumansCells
  46. Higgins JM, Eddington DT, Bhatia SN, Mahadevan L. Review of an in vitro microfluidic model of sickle cell vaso-occlusion. Transfus Clin Biol. 2008 Feb-Mar; 15(1-2):12-3. PMID: 18495515.
    Citations:    Fields:    Translation:Humans
  47. Sabeti PC, Reich DE, Higgins JM, Levine HZ, Richter DJ, Schaffner SF, Gabriel SB, Platko JV, Patterson NJ, McDonald GJ, Ackerman HC, Campbell SJ, Altshuler D, Cooper R, Kwiatkowski D, Ward R, Lander ES. Detecting recent positive selection in the human genome from haplotype structure. Nature. 2002 Oct 24; 419(6909):832-7. PMID: 12397357.
    Citations: 784     Fields:    Translation:HumansAnimals
  48. Reich DE, Schaffner SF, Daly MJ, McVean G, Mullikin JC, Higgins JM, Richter DJ, Lander ES, Altshuler D. Human genome sequence variation and the influence of gene history, mutation and recombination. Nat Genet. 2002 Sep; 32(1):135-42. PMID: 12161752.
    Citations: 90     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.